Sandra Kleinau
Professor vid Institutionen för cell- och molekylärbiologi; Mikrobiologi och immunologi
- Telefon:
- 018-471 40 61
- E-post:
- Sandra.Kleinau@icm.uu.se
- Besöksadress:
- Husargatan 3
752 37 Uppsala - Postadress:
- Box 596
751 24 Uppsala
- Akademiska meriter:
- docent
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Kort presentation
Sandra Kleinau är professor i molekylär immunologi och studerar immunförsvaret vid hälsa och sjukdom. Immunceller skyddar oss mot smittämnen och håller oss friska. Men hur kommer det sig att de ibland felaktigt börjar att attackera den egna kroppen såsom i en autoimmun sjukdom? Skulle man kunna lära sig av den missriktade attacken för att hitta en bot och samtidigt skapa en immunterapi som kan slå ut cancerceller? Svaren på dessa frågor saknas och är något som driver forskargruppens arbete.
Nyckelord
- antibodies
- autoimmunity
- b lymphocytes
- chronic inflammation
- fc receptors
- immunobiology
- immunology
- immunotherapy
- macrophages
- monocytes
- rheumatoid arthritis
Biografi
Professor i biologi; särskilt molekylär immunologi, UU (2008-)
Lektor i biologi; särskilt molekylär immunologi, UU (2004-2008)
Forskare, Göran Gustafssons stiftelse, UU (2001-2003)
Forskare, Karo Bio (2000)
Forskarassistent, UU (1997-2000)
Docent i experimentell patologi, UU (1999)
Postdoktor i experimentell patologi, UU (1996-1997)
Postdoktor i medicin, Karolinska Institutet (1994-1995)
PhD i klinisk immunologi, UU (1993)
BSc, UU (1989)
Forskningsingenjör, Pharmacia AB (1984-89)
Publikationer
Urval av publikationer
- Proteolysis Breaks Tolerance toward Intact alpha 345(IV) Collagen, Eliciting Novel Anti-Glomerular Basement Membrane Autoantibodies Specific for alpha 345NC1 Hexamers (2013)
- Up Regulated Complement and Fc Receptors in Juvenile Idiopathic Arthritis and Correlation with Disease Phenotype (2012)
- Murine Membranous Nephropathy (2012)
- Marginal zone B cells are naturally reactive to collagen type II and are involved in the initiation of the immune response in collagen-induced arthritis (2011)
- FcgammaRIII-expressing macrophages are essential for development of collagen-induced arthritis. (2006)
- IgG immune complex-binding in macrophages from arthritis-susceptible and arthritis-resistant mice following collagen type II immunization. (2006)
- IgG Fc receptor polymorphisms and association with autoimmune disease. (2005)
- Gene targeting by ribozyme against TNF-alpha mRNA inhibits autoimmune arthritis. (2005)
- The impact of Fc receptors on the development of autoimmune diseases. (2003)
- Induction of arthritis by single monoclonal IgG anti-collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory FcgammaRIIB. (2003)
- Human problems - animal models: Aspects on the use of inducible experimental arthritis for pathogenetic studies of human inflammatory joint disease (1995)
Senaste publikationer
- Impact of Fc receptors and host characteristics on myeloid phagocytic response to rituximab-treated 3D-cultured B-cell lymphoma (2023)
- The Human Monocyte (2022)
- Exploring complement-dependent cytotoxicity by rituximab isotypes in 2D and 3D-cultured B-cell lymphoma (2022)
- Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems (2022)
- Importance of antibody isotypes in antitumor immunity by monocytes and complement using human-immune tumor models (2021)
Alla publikationer
Artiklar
- Impact of Fc receptors and host characteristics on myeloid phagocytic response to rituximab-treated 3D-cultured B-cell lymphoma (2023)
- The Human Monocyte (2022)
- Exploring complement-dependent cytotoxicity by rituximab isotypes in 2D and 3D-cultured B-cell lymphoma (2022)
- Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems (2022)
- Importance of antibody isotypes in antitumor immunity by monocytes and complement using human-immune tumor models (2021)
- Marginal zone B cells (2021)
- On The Relationship between Rheumatoid Factors, Monocyte Subsets and FC Receptor Function in Early Ra (2016)
- Identification of self-reactive marginal-zone B cell like cells in lymph nodes of mice (2016)
- Nodal marginal zone B cells in mice (2016)
- Activated mast cells promote differentiation of B cells into effector cells (2016)
- Up-regulation of CD64-expressing monocytes with impaired Fc gamma R function reflects disease activity in polyarticular psoriatic arthritis (2015)
- Elevated Membrane and Soluble CD64 (2015)
- Function and regulation of self-reactive marginal zone B cells in autoimmune arthritis (2015)
- Dysregulated Fc receptor function in active rheumatoid arthritis (2014)
- Identification of a Population of Lymph Node Marginal Zone B Cells that Expand in Mice Developing Autoimmune Arthritis (2014)
- Evidence of Marginal Zone B Cells in the Lymph Nodes Presenting Autoantigen to T Cells in a Model of Autoimmune Arthritis (2014)
- AB0102 Effects of anti-rheumatic treatment on antibody levels and monocytic fc receptor status in early ra (2013)
- Proteolysis Breaks Tolerance toward Intact alpha 345(IV) Collagen, Eliciting Novel Anti-Glomerular Basement Membrane Autoantibodies Specific for alpha 345NC1 Hexamers (2013)
- Expansion of a marginal zone B cell-like population in lymph nodes of mice developing collagen-induced arthritis (2013)
- Marginal zone B cells in autoimmune arthritis (2012)
- Molecular Basis for T Cell Response Induced by Altered Peptide Ligand of Type II Collagen (2012)
- Up Regulated Complement and Fc Receptors in Juvenile Idiopathic Arthritis and Correlation with Disease Phenotype (2012)
- Murine Membranous Nephropathy (2012)
- Marginal zone B cells are naturally reactive to collagen type II and are involved in the initiation of the immune response in collagen-induced arthritis (2011)
- T Cells Stimulated With an Analog Peptide of Type II Collagen Require the Fc Receptor gamma-Chain to Secrete Interleukin-4 and Suppress Autoimmune Arthritis in Mice (2011)
- Enhanced susceptibility to low-dose collagen-induced arthritis in CR1/2-deficient female mice (2009)
- Amelioration of collagen-induced arthritis by human recombinant soluble FcγRIIb (2008)
- The effect of activating and inhibiting Fc-receptors on murine mercury-induced autoimmunity. (2008)
- FcgammaRIII-expressing macrophages are essential for development of collagen-induced arthritis. (2006)
- IgG immune complex-binding in macrophages from arthritis-susceptible and arthritis-resistant mice following collagen type II immunization. (2006)
- IgG Fc receptor polymorphisms and association with autoimmune disease. (2005)
- Gene targeting by ribozyme against TNF-alpha mRNA inhibits autoimmune arthritis. (2005)
- The impact of Fc receptors on the development of autoimmune diseases. (2003)
- Induction of arthritis by single monoclonal IgG anti-collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory FcgammaRIIB. (2003)
- Activated mast cells promote a pro-inflammatory phenotype of B cells
Kapitel
