Lene Uhrbom

Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival

Lu, Xi; Maturi, Naga Prathyusha; Jarvius, Malin; Yildirim, Irem et al.

Ingår i Nature Communications, 2022

• DOI för Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival
• Ladda ner fulltext (pdf) av Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival

A molecularly distinct subset of glioblastoma requires serum-containing media to establish sustainable bona fide glioblastoma stem cell cultures

Maturi, Naga Prathyusha; Tan, E-Jean; Xie, Yuan; Sundström, Anders et al.

Ingår i Glia, s. 1228-1240, 2020

• DOI för A molecularly distinct subset of glioblastoma requires serum-containing media to establish sustainable bona fide glioblastoma stem cell cultures

LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Xie, Yuan; Sundström, Anders; Maturi, Naga P; Tan, E-Jean et al.

Ingår i Journal of Pathology, s. 228-240, 2019

• DOI för LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

Jiang, Yiwen; Marinescu, Voichita Dana; Xie, Yuan; Jarvius, Malin et al.

Ingår i Cell Reports, s. 977-990, 2017

• DOI för Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin
• Ladda ner fulltext (pdf) av Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype

Sreedharan, Smitha; Maturi, Naga Prathyusha; Xie, Yuan; Sundström, Anders et al.

Ingår i Cancer Research, s. 802-812, 2017

• DOI för Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype

The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes

Xie, Yuan; Bergström, Tobias; Jiang, Yiwen; Johansson, Patrik et al.

Ingår i EBioMedicine, s. 1351-1363, 2015

• DOI för The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes
• Ladda ner fulltext (pdf) av The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes

Oncogenic Signaling Is Dominant to Cell of Origin and Dictates Astrocytic or Oligodendroglial Tumor Development from Oligodendrocyte Precursor Cells

Lindberg, Nanna; Jiang, Yiwen; Xie, Yuan; Bolouri, Hamid et al.

Ingår i Journal of Neuroscience, s. 14644-14651, 2014

• DOI för Oncogenic Signaling Is Dominant to Cell of Origin and Dictates Astrocytic or Oligodendroglial Tumor Development from Oligodendrocyte Precursor Cells

Oligodendroglioma models

Lindberg, Nanna; Uhrbom, Lene

Ingår i Animal Models of Brain Tumors, s. 57-82, Humana Press, 2013

• DOI för Oligodendroglioma models

On the origin of glioma

Jiang, Yiwen; Uhrbom, Lene

Ingår i Upsala Journal of Medical Sciences, s. 113-121, 2012

• DOI för On the origin of glioma

RAD51 can inhibit PDGFB-induced gliomagenesis and genomic instability

Westermark, Ulrica K; Lindberg, Nanna; Roswall, Pernilla; Bråsäter, Daniel et al.

Ingår i Neuro-Oncology, s. 1277-1287, 2011

• DOI för RAD51 can inhibit PDGFB-induced gliomagenesis and genomic instability

Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma

Lindberg, Nanna; Kastemar, Marianne; Olofsson, T; Smits, Anja et al.

Ingår i Oncogene, s. 2266-2275, 2009

• DOI för Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma

Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence

Tchougounova, Elena; Jiang, Yiwen; Bråsäter, Daniel; Lindberg, Nanna et al.

Ingår i Oncogene, s. 1537-1548, 2009

• DOI för Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence

Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma

Tchougounova, Elena; Kastemar, Marianne; Bråsäter, Daniel; Holland, E C et al.

Ingår i Oncogene, s. 6289-6296, 2007

• DOI för Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma

Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis.

Uhrbom, Lene; Kastemar, Marianne; Johansson, Fredrik K; Westermark, Bengt et al.

Ingår i Cancer Res, s. 2065-9, 2005

Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model.

Uhrbom, Lene; Nerio, Edward; Holland, Eric C

Ingår i Nat Med, s. 1257-60, 2004

Somatic cell gene transfer

Uhrbom, Lene; Holland, Eric C

Ingår i Mouse Models Of Human Cancer, s. 474, Wiley-Liss, Inc., Hoboken, New Jersey, 2004

Complementary effects of platelet-derived growth factor autocrine stimulation and p53 or Ink4a-Arf deletion in a mouse glioma model.

Hesselager, Göran; Uhrbom, Lene; Westermark, Bengt; Nister, Monica

Ingår i Cancer Research, s. 4305, 2003

Dissecting gliomagemesis using glial-specifictransgenic mouse models

Begemann, Martin; Uhrbom, Lene; Rajasekhar, VK; Fuller, Gregory N et al.

Ingår i Genomic and Molecular Neuro-Oncology, Jones & Bartlett Publishers, Inc, 2003

Ink4a-Arf loss cooperates with KRas activation in astrocytes and neuralprogenitors to generate glioblastomas of various morphologies depending onactivated Akt.

Uhrbom, Lene; Dai, Chengkai; Celestino, Joseph C; Rosenblum, Marc K et al.

Ingår i Cancer Res, s. 5551, 2002

Modeling gliomagenesis with somatic cell gene transfer using retroviral vectors.

Uhrbom, Lene; Holland, E C

Ingår i J Neurooncol, s. 297-305, 2001

Glial tumors of the CNS

Nistér, Monica; Uhrbom, Lene; Hesselager, Göran; Westermark, Bengt

Ingår i Glial Cell Development, s. 437, Oxford University Press, 2001

Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells

Uhrbom, Lene; Hesselager, Göran; Östman, Arne; Nistér, Monica et al.

Ingår i Int J Cancer, s. 398-406, 2000

Induction of brain tumors in mice using a recombinant PDGF B retrovirus

Uhrbom, Lene; Hesselager, Göran; Nister, Monica; Westermark, Bengt

Ingår i Cancer Research, s. 5275-5279, 1998

Induction of senescence in human malignant glioma cells by p16INK4A

Uhrbom, Lene; Nister, Monica; Westermark, Bengt

Ingår i Oncogene, s. 111, 1997

TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers

Damhofer, Helene; Tatar, Tülin; Southgate, Benjamin; Scarneo, Scott et al.

Ingår i Cell Death and Disease, 2024

• DOI för TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers
• Ladda ner fulltext (pdf) av TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers

Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma

Ramachandran, Mohanraj; Vaccaro, Alessandra; van de Walle, Tiarne; Georganaki, Maria et al.

Ingår i Cancer Cell, s. 1134-1151, 2023

• DOI för Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma
• Ladda ner fulltext (pdf) av Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma

Live Detection of Neural Progenitors and Glioblastoma Cells by an Oligothiophene Derivative

Ilkhanizadeh, Shirin; Gracias, Aileen; Aslund, Andreas K. O.; Back, Marcus et al.

Ingår i ACS Applied Bio Materials, s. 3790-3797, 2023

• DOI för Live Detection of Neural Progenitors and Glioblastoma Cells by an Oligothiophene Derivative
• Ladda ner fulltext (pdf) av Live Detection of Neural Progenitors and Glioblastoma Cells by an Oligothiophene Derivative

Wnt signaling regulates MFSD2A-dependent drug delivery through endothelial transcytosis in glioma

Xie, Yuan; He, Liqun; Zhang, Yanyu; Huang, Hua et al.

Ingår i Neuro-Oncology, s. 1073-1084, 2023

• DOI för Wnt signaling regulates MFSD2A-dependent drug delivery through endothelial transcytosis in glioma

Glioblastoma stem cells express non-canonical proteins and exclusive mesenchymal-like or non-mesenchymal-like protein signatures

Babacic, Haris; Galardi, Silvia; Umer, Husen M.; Hellström, Mats et al.

Ingår i Molecular Oncology, s. 238-260, 2023

• DOI för Glioblastoma stem cells express non-canonical proteins and exclusive mesenchymal-like or non-mesenchymal-like protein signatures
• Ladda ner fulltext (pdf) av Glioblastoma stem cells express non-canonical proteins and exclusive mesenchymal-like or non-mesenchymal-like protein signatures

TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers

Damhofer, Helene; Tatar, Tülin; Southgate, Benjamin; Scarneo, Scott et al.

Ingår i Cell Death and Disease, 2024

• DOI för TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers
• Ladda ner fulltext (pdf) av TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers

Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma

Ramachandran, Mohanraj; Vaccaro, Alessandra; van de Walle, Tiarne; Georganaki, Maria et al.

Ingår i Cancer Cell, s. 1134-1151, 2023

• DOI för Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma
• Ladda ner fulltext (pdf) av Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma

Live Detection of Neural Progenitors and Glioblastoma Cells by an Oligothiophene Derivative

Ilkhanizadeh, Shirin; Gracias, Aileen; Aslund, Andreas K. O.; Back, Marcus et al.

Ingår i ACS Applied Bio Materials, s. 3790-3797, 2023

• DOI för Live Detection of Neural Progenitors and Glioblastoma Cells by an Oligothiophene Derivative
• Ladda ner fulltext (pdf) av Live Detection of Neural Progenitors and Glioblastoma Cells by an Oligothiophene Derivative

Wnt signaling regulates MFSD2A-dependent drug delivery through endothelial transcytosis in glioma

Xie, Yuan; He, Liqun; Zhang, Yanyu; Huang, Hua et al.

Ingår i Neuro-Oncology, s. 1073-1084, 2023

• DOI för Wnt signaling regulates MFSD2A-dependent drug delivery through endothelial transcytosis in glioma

Glioblastoma stem cells express non-canonical proteins and exclusive mesenchymal-like or non-mesenchymal-like protein signatures

Babacic, Haris; Galardi, Silvia; Umer, Husen M.; Hellström, Mats et al.

Ingår i Molecular Oncology, s. 238-260, 2023

• DOI för Glioblastoma stem cells express non-canonical proteins and exclusive mesenchymal-like or non-mesenchymal-like protein signatures
• Ladda ner fulltext (pdf) av Glioblastoma stem cells express non-canonical proteins and exclusive mesenchymal-like or non-mesenchymal-like protein signatures

Novel cancer gene discovery using a forward genetic screen in RCAS-PDGFB-driven gliomas

Weishaupt, Holger; Čančer, Matko; Rosén, Gabriela; Holmberg, Karl O. et al.

Ingår i Neuro-Oncology, s. 97-107, 2023

• DOI för Novel cancer gene discovery using a forward genetic screen in RCAS-PDGFB-driven gliomas
• Ladda ner fulltext (pdf) av Novel cancer gene discovery using a forward genetic screen in RCAS-PDGFB-driven gliomas

Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival

Lu, Xi; Maturi, Naga Prathyusha; Jarvius, Malin; Yildirim, Irem et al.

Ingår i Nature Communications, 2022

• DOI för Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival
• Ladda ner fulltext (pdf) av Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival

FACT-seq: profiling histone modifications in formalin-fixed paraffin-embedded samples with low cell numbers

Zhao, Linxuan; Xing, Pengwei; Polavarapu, Vamsi Krishna; Zhao, Miao et al.

Ingår i Nucleic Acids Research, 2021

• DOI för FACT-seq: profiling histone modifications in formalin-fixed paraffin-embedded samples with low cell numbers
• Ladda ner fulltext (pdf) av FACT-seq: profiling histone modifications in formalin-fixed paraffin-embedded samples with low cell numbers

Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing

Xie, Yuan; He, Liqun; Lugano, Roberta; Zhang, Yanyu et al.

Ingår i JCI Insight, 2021

• DOI för Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing
• Ladda ner fulltext (pdf) av Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing

A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma

Johansson, Patrik; Krona, Cecilia; Kundu, Soumi; Doroszko, Milena et al.

Ingår i Cell Reports, 2020

• DOI för A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma
• Ladda ner fulltext (pdf) av A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma

A molecularly distinct subset of glioblastoma requires serum-containing media to establish sustainable bona fide glioblastoma stem cell cultures

Maturi, Naga Prathyusha; Tan, E-Jean; Xie, Yuan; Sundström, Anders et al.

Ingår i Glia, s. 1228-1240, 2020

• DOI för A molecularly distinct subset of glioblastoma requires serum-containing media to establish sustainable bona fide glioblastoma stem cell cultures

BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells

Cancer, Matko; Drews, Lisa F.; Bengtsson, Johan; Bolin, Sara et al.

Ingår i Cell Death and Disease, 2019

• DOI för BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells
• Ladda ner fulltext (pdf) av BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells

LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Xie, Yuan; Sundström, Anders; Maturi, Naga P; Tan, E-Jean et al.

Ingår i Journal of Pathology, s. 228-240, 2019

• DOI för LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors

Kaffes, Ioannis; Szulzewsky, Frank; Chen, Zhihong; Herting, Cameron J. et al.

Ingår i Oncoimmunology, 2019

• DOI för Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors
• Ladda ner fulltext (pdf) av Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors

Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells

Caja, Laia; Tzavlaki, Kalliopi; Dadras, Mahsa Shahidi; Tan, E-Jean et al.

Ingår i Oncogene, s. 2515-2531, 2018

• DOI för Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells
• Ladda ner fulltext (pdf) av Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells

Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity

Wallmann, Tatjana; Zhang, Xing-Mei; Wallerius, Majken; Bolin, Sara et al.

Ingår i iScience, s. 71-83, 2018

• DOI för Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity
• Ladda ner fulltext (pdf) av Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity

Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

Jiang, Yiwen; Marinescu, Voichita Dana; Xie, Yuan; Jarvius, Malin et al.

Ingår i Cell Reports, s. 977-990, 2017

• DOI för Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin
• Ladda ner fulltext (pdf) av Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

Mast Cell Infiltration in Human Brain Metastases Modulates the Microenvironment and Contributes to the Metastatic Potential

Roy, Ananya; Libard, Sylwia; Weishaupt, Holger; Gustavsson, Ida et al.

Ingår i Frontiers in Oncology, 2017

• DOI för Mast Cell Infiltration in Human Brain Metastases Modulates the Microenvironment and Contributes to the Metastatic Potential
• Ladda ner fulltext (pdf) av Mast Cell Infiltration in Human Brain Metastases Modulates the Microenvironment and Contributes to the Metastatic Potential

Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype

Sreedharan, Smitha; Maturi, Naga Prathyusha; Xie, Yuan; Sundström, Anders et al.

Ingår i Cancer Research, s. 802-812, 2017

• DOI för Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype

Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses

Niklasson, Mia; Maddalo, Gianluca; Sramkova, Zuzana; Mutlu, Ercan et al.

Ingår i Cancer Research, s. 1741-1752, 2017

• DOI för Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses

Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition

Segerman, Anna; Niklasson, Mia; Haglund, Caroline; Bergström, Tobias et al.

Ingår i Cell Reports, s. 2994-3009, 2016

• DOI för Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition
• Ladda ner fulltext (pdf) av Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition

Case-specific potentiation of glioblastoma drugs by pterostilbene

Schmidt, Linnéa; Baskaran, Sathishkumar; Johansson, Patrik; Padhan, Narendra et al.

Ingår i Oncotarget, s. 73200-73215, 2016

• DOI för Case-specific potentiation of glioblastoma drugs by pterostilbene

Pleiotrophin enhances PDGFB-induced gliomagenesis through increased proliferation of neural progenitor cells

Zhang, Lei; Laaniste, Liisi; Jiang, Yiwen; Alafuzoff, Irina et al.

Ingår i Oncotarget, s. 80382-80390, 2016

• DOI för Pleiotrophin enhances PDGFB-induced gliomagenesis through increased proliferation of neural progenitor cells
• Ladda ner fulltext (pdf) av Pleiotrophin enhances PDGFB-induced gliomagenesis through increased proliferation of neural progenitor cells

ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells

Wee, Boyoung; Pietras, Alexander; Ozawa, Tatsuya; Bazzoli, Elena et al.

Ingår i Scientific Reports, 2016

• DOI för ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells
• Ladda ner fulltext (pdf) av ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells

Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells

Roy, Ananya; Coum, Antoine; Marinescu, Voichita D; Põlajeva, Jelena et al.

Ingår i Oncotarget, s. 23647-23661, 2015

• DOI för Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells
• Ladda ner fulltext (pdf) av Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells

The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes

Xie, Yuan; Bergström, Tobias; Jiang, Yiwen; Johansson, Patrik et al.

Ingår i EBioMedicine, s. 1351-1363, 2015

• DOI för The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes
• Ladda ner fulltext (pdf) av The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes

Etomidate, propofol and diazepam potentiate GABA-evoked GABAA currents in a cell line derived from Human glioblastoma

Babateen, Omar; Jin, Zhe; Bhandage, Amol K.; Korol, Sergiy V et al.

Ingår i European Journal of Pharmacology, s. 101-107, 2015

• DOI för Etomidate, propofol and diazepam potentiate GABA-evoked GABAA currents in a cell line derived from Human glioblastoma

GABA-A receptor currents in a cell line (U3047MG) derived from a human glioblastoma tumor are enhanced by etomidate, propofol and diazepam

Babateen, Omar M.; Jin, Zhe; Bhandage, Amol K.; Korol, Sergiy V. et al.

Ingår i Acta Physiologica, s. 100-100, 2014

Oncogenic Signaling Is Dominant to Cell of Origin and Dictates Astrocytic or Oligodendroglial Tumor Development from Oligodendrocyte Precursor Cells

Lindberg, Nanna; Jiang, Yiwen; Xie, Yuan; Bolouri, Hamid et al.

Ingår i Journal of Neuroscience, s. 14644-14651, 2014

• DOI för Oncogenic Signaling Is Dominant to Cell of Origin and Dictates Astrocytic or Oligodendroglial Tumor Development from Oligodendrocyte Precursor Cells

Selective Calcium Sensitivity in Immature Glioma Cancer Stem Cells

Wee, Shimei; Niklasson, Maria; Marinescu, Voichita Dana; Segerman, Anna et al.

Ingår i PLOS ONE, 2014

• DOI för Selective Calcium Sensitivity in Immature Glioma Cancer Stem Cells
• Ladda ner fulltext (pdf) av Selective Calcium Sensitivity in Immature Glioma Cancer Stem Cells

Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures

Yu, Di; Jin, Chuan; Ramachandran, Mohanraj; Xu, Jing et al.

Ingår i PLOS ONE, 2013

• DOI för Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures
• Ladda ner fulltext (pdf) av Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures

Comparative drug pair screening across multiple glioblastoma cell lines reveals novel drug-drug interactions

Schmidt, Linnea; Kling, Teresia; Monsefi, Naser; Olsson, Maja et al.

Ingår i Neuro-Oncology, s. 1469-1478, 2013

• DOI för Comparative drug pair screening across multiple glioblastoma cell lines reveals novel drug-drug interactions

miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma

Põlajeva, Jelena; Swartling, Fredrik; Jiang, Yiwen; Singh, Umashankar et al.

Ingår i BMC Cancer, s. 378, 2012

• DOI för miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma
• Ladda ner fulltext (pdf) av miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma

On the origin of glioma

Jiang, Yiwen; Uhrbom, Lene

Ingår i Upsala Journal of Medical Sciences, s. 113-121, 2012

• DOI för On the origin of glioma

CGGBP1 regulates cell cycle in cancer cells

Singh, Umashankar; Roswall, Pernilla; Uhrbom, Lene; Westermark, Bengt

Ingår i BMC Molecular Biology, s. 28, 2011

• DOI för CGGBP1 regulates cell cycle in cancer cells
• Ladda ner fulltext (pdf) av CGGBP1 regulates cell cycle in cancer cells

Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells

Ferletta, Maria; Caglayan, Demet; Mokvist, Liza; Yiwen, Jiang et al.

Ingår i International Journal of Cancer, s. 45-60, 2011

• DOI för Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells

PDGF-B Can sustain self-renewal and tumorigenicity of experimental glioma-derived cancer-initiating cells by preventing oligodendrocyte differentiation

Jiang, Yiwen; Boije, Maria; Westermark, Bengt; Uhrbom, Lene

Ingår i Neoplasia, s. 492-503, 2011

• DOI för PDGF-B Can sustain self-renewal and tumorigenicity of experimental glioma-derived cancer-initiating cells by preventing oligodendrocyte differentiation

RAD51 can inhibit PDGFB-induced gliomagenesis and genomic instability

Westermark, Ulrica K; Lindberg, Nanna; Roswall, Pernilla; Bråsäter, Daniel et al.

Ingår i Neuro-Oncology, s. 1277-1287, 2011

• DOI för RAD51 can inhibit PDGFB-induced gliomagenesis and genomic instability

Mast Cell Accumulation in Glioblastoma with a Potential Role for Stem Cell Factor and Chemokine CXCL12

Põlajeva, Jelena; Sjösten, Anna M; Lager, Nina; Kastemar, Marianne et al.

Ingår i PLOS ONE, 2011

• DOI för Mast Cell Accumulation in Glioblastoma with a Potential Role for Stem Cell Factor and Chemokine CXCL12
• Ladda ner fulltext (pdf) av Mast Cell Accumulation in Glioblastoma with a Potential Role for Stem Cell Factor and Chemokine CXCL12

Histidine-rich glycoprotein can prevent development of mouse experimental glioblastoma

Kärrlander, Maria; Lindberg, Nanna; Olofsson, Tommie; Kastemar, Marianne et al.

Ingår i PLoS ONE, 2009

• DOI för Histidine-rich glycoprotein can prevent development of mouse experimental glioblastoma

Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma

Lindberg, Nanna; Kastemar, Marianne; Olofsson, T; Smits, Anja et al.

Ingår i Oncogene, s. 2266-2275, 2009

• DOI för Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma

Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence

Tchougounova, Elena; Jiang, Yiwen; Bråsäter, Daniel; Lindberg, Nanna et al.

Ingår i Oncogene, s. 1537-1548, 2009

• DOI för Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence

IGFBP2 is a candidate biomarker for Ink4a-Arf status and a therapeutic target for high-grade gliomas

Moore, Lynette M; Holmes, Kristen M; Smith, Sarah M; Wu, Ying et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 16675-16679, 2009

• DOI för IGFBP2 is a candidate biomarker for Ink4a-Arf status and a therapeutic target for high-grade gliomas

Sox10 Has a Broad Expression Pattern in Gliomas and Enhances Platelet-Derived Growth Factor-B–Induced Gliomagenesis

Ferletta, Maria; Uhrbom, Lene; Olofsson, Tommie; Pontén, Fredrik et al.

Ingår i Molecular Cancer Research, s. 891-897, 2007

• DOI för Sox10 Has a Broad Expression Pattern in Gliomas and Enhances Platelet-Derived Growth Factor-B–Induced Gliomagenesis

Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma

Tchougounova, Elena; Kastemar, Marianne; Bråsäter, Daniel; Holland, E C et al.

Ingår i Oncogene, s. 6289-6296, 2007

• DOI för Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma

Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis.

Uhrbom, Lene; Kastemar, Marianne; Johansson, Fredrik K; Westermark, Bengt et al.

Ingår i Cancer Res, s. 2065-9, 2005

Identification of candidate cancer-causing genes in mouse brain tumors by retroviral tagging

Johansson, Fredrik K.; Brodd, Josefin; Eklöf, Charlotta; Ferletta, Maria et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 11334-11337, 2004

• DOI för Identification of candidate cancer-causing genes in mouse brain tumors by retroviral tagging

Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model.

Uhrbom, Lene; Nerio, Edward; Holland, Eric C

Ingår i Nat Med, s. 1257-60, 2004

p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3.

Wolf, Rebecca M.; Draghi, Nicole; Liang, Xiquan; Dai, Chengkai et al.

Ingår i Development, Genes and Evolution, s. 476-487, 2003

• DOI för p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3.

Complementary effects of platelet-derived growth factor autocrine stimulation and p53 or Ink4a-Arf deletion in a mouse glioma model.

Hesselager, Göran; Uhrbom, Lene; Westermark, Bengt; Nister, Monica

Ingår i Cancer Research, s. 4305, 2003

Ink4a-Arf loss cooperates with KRas activation in astrocytes and neuralprogenitors to generate glioblastomas of various morphologies depending onactivated Akt.

Uhrbom, Lene; Dai, Chengkai; Celestino, Joseph C; Rosenblum, Marc K et al.

Ingår i Cancer Res, s. 5551, 2002

Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells

Uhrbom, Lene; Hesselager, Göran; Östman, Arne; Nistér, Monica et al.

Ingår i Int J Cancer, s. 398-406, 2000

Induction of brain tumors in mice using a recombinant PDGF B retrovirus

Uhrbom, Lene; Hesselager, Göran; Nister, Monica; Westermark, Bengt

Ingår i Cancer Research, s. 5275-5279, 1998

Induction of senescence in human malignant glioma cells by p16INK4A

Uhrbom, Lene; Nister, Monica; Westermark, Bengt

Ingår i Oncogene, s. 111, 1997

Modeling gliomagenesis with somatic cell gene transfer using retroviral vectors.

Uhrbom, Lene; Holland, E C

Ingår i J Neurooncol, s. 297-305, 2001

Oligodendroglioma models

Lindberg, Nanna; Uhrbom, Lene

Ingår i Animal Models of Brain Tumors, s. 57-82, Humana Press, 2013

• DOI för Oligodendroglioma models

Somatic cell gene transfer

Uhrbom, Lene; Holland, Eric C

Ingår i Mouse Models Of Human Cancer, s. 474, Wiley-Liss, Inc., Hoboken, New Jersey, 2004

Dissecting gliomagemesis using glial-specifictransgenic mouse models

Begemann, Martin; Uhrbom, Lene; Rajasekhar, VK; Fuller, Gregory N et al.

Ingår i Genomic and Molecular Neuro-Oncology, Jones & Bartlett Publishers, Inc, 2003

Glial tumors of the CNS

Nistér, Monica; Uhrbom, Lene; Hesselager, Göran; Westermark, Bengt

Ingår i Glial Cell Development, s. 437, Oxford University Press, 2001

Targeting SOX2 in glioblastoma cells reveals heterogeneity in SOX2 dependency

Dalmo, Erika; Rosén, Gabriela; Niklasson, Mia; Bergström, Tobias et al.

Enhancer signatures define glioblastoma stem cell subtypes 1 with divergent patient survival

Xing, Pengwei; Neves, Ines; Salehi, Maede; Yadav, Ram Prakash et al.

Paired glioblastoma cell cultures of the fluorescent bulk tumor and non-fluorescent tumor margin display differential phenotypes and cell states across patients

Neves, Inês; Lu, Xi; Maturi, Nagaprathyusha; Dang, Yonglong et al.