Peter Nygren

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Mansoori, Sharmineh; Blom, Kristin; Andersson, Claes; Fryknäs, Mårten et al.

Ingår i Oncology Reports, 2026

DOI för Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model
Ladda ner fulltext (pdf) av Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus

Eloranta, Maija-Leena; Nygren, Peter; Larsson, Rolf; Loskog, Angelica et al.

Ingår i Scientific Reports, 2026

Ex vivo drug responses and molecular profiles of 597 pediatric acute lymphoblastic leukemia patients

Enblad, Anna Pia; Krali, Olga; Gezelius, Henrik; Lundmark, Anders et al.

Ingår i HemaSphere, 2025

Preoperative chemotherapy in colorectal peritoneal metastatic disease: a real-world observational cohort study

Cashin, Peter; Frühling, Petter; Grönlund, Pontus; Graf, Wilhelm et al.

Ingår i Pleura and Peritoneum, s. 1-10, 2025

Clinical characteristics and treatment outcome in p16 negative anal cancer

Burgos, Catherine; Radu, Calin; Heyman, Sofia; Cavalli-Björkman, Nina et al.

Ingår i Acta Oncologica, s. 633-640, 2025

Precision cancer medicine 2025: some concerns

Nygren, Peter

Ingår i Acta Oncologica, s. 1202-1204, 2025

Feasibility and outcome of genomics-guided treatment selection in advanced cancer: the MEGALiT explorative clinical trial

Ny, Lars; Fagman, Henrik; Botling, Johan; Mantovaara, Loviisa et al.

Ingår i Acta Oncologica, s. 742-750, 2025

A Randomized Phase III Study of Arfolitixorin versus Leucovorin with 5-Fluorouracil, Oxaliplatin, and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer: The AGENT Trial

Tabernero, Josep; Yoshino, Takayuki; Stintzing, Sebastian; de Gramont, Aimery et al.

Ingår i Cancer Research Communications, s. 28-37, 2024

Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment

Selvin, Tove; Berglund, Malin; Lenhammar, Lena; Lindskog, Magnus et al.

Ingår i BMC Pharmacology & Toxicology, 2024

The value of post-operative chemotherapy after chemoradiotherapy in patients with high-risk locally advanced rectal cancerdresults from the RAPIDO trial

Dijkstra, E. A.; Zwart, W. H.; Nilsson, P. J.; Putter, H. et al.

Ingår i ESMO Open, 2023

DOI för The value of post-operative chemotherapy after chemoradiotherapy in patients with high-risk locally advanced rectal cancerdresults from the RAPIDO trial

Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death

Selvin, Tove; Berglund, Malin; Lenhammar, Lena; Jarvius, Malin et al.

Ingår i BMC Cancer, 2023

Ex vivo assessment of chemotherapy sensitivity of colorectal cancer peritoneal metastases

Cashin, Peter; Söderström, Maria; Blom, Kristin; Artursson, Sara et al.

Ingår i British Journal of Surgery, s. 1080-1083, 2023

Assessment in vitro of interactions between anti-cancer drugs and noncancer drugs commonly used by cancer patients

Andersson, Claes; Ye, Jiawei; Blom, Kristin; Fryknäs, Mårten et al.

Ingår i Anti-Cancer Drugs, s. 92-102, 2023

Selective radiosensitization by nitazoxanide of quiescent clonogenic colon cancer tumour cells

Karlsson, Henning; Fryknäs, Mårten; Senkowski, Wojciech; Larsson, Rolf et al.

Ingår i Oncology Letters, 2022

Ex vivo assessment of cancer drug sensitivity in epithelial ovarian cancer and its association with histopathological type, treatment history and clinical outcome

Bjersand, Kathrine; Blom, Kristin; Sundström Poromaa, Inger; Stålberg, Karin et al.

Ingår i International Journal of Oncology, 2022

Evaluation and validation of chemotherapy‐specific diarrhoea and histopathology in rats

Dahlgren, David; Rosenqvist, Evelina; Hellström, Per M.; Nygren, Peter et al.

Ingår i Basic & Clinical Pharmacology & Toxicology, s. 536-546, 2022

Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma

Nyberg, Frida; Blom, Kristin; Selvin, Tove; Rudfeldt, Jakob et al.

Ingår i Scientific Reports, 2022

Fördelaktigt med genetisk analys före behandling med 5-fluorouracil: Utvärdering tyder på mindre biverkningar och kostnadsbesparing för sjukvården: [New recommendation on pharmacogenetic screening prior to 5-fluorouracil based cancer treatment - Swedish experience indicates less adverse effects and healthcare cost savings]

Schultz, Alice; Kohnke, Hugo; Wadelius, Mia; Nygren, Peter

Ingår i Läkartidningen, 2021

Does exercise intensity matter for fatigue during (neo)adjuvant cancer treatment?: The PhysCan randomized clinical trial

Demmelmaier, Ingrid; Brooke, Hannah L.; Henriksson, Anna; Mazzoni, Anne-Sophie et al.

Ingår i Scandinavian Journal of Medicine and Science in Sports, s. 1144-1159, 2021

A phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer

Mansoori, Sharmineh; Fryknäs, Mårten; Alvfors, Carina; Loskog, Angelica et al.

Ingår i Scientific Reports, 2021

Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Rendo, Verónica; Stoimenov, Ivaylo; Mateus, André; Sjöberg, Elin et al.

Ingår i Nature Communications, 2020

Cocreated internet-based stepped care for individuals with cancer and concurrent symptoms of anxiety and depression: Results from the U-CARE AdultCan randomized controlled trial

Hauffman, Anna; Alfonsson, Sven; Bill-Axelson, Anna; Bergkvist, Leif et al.

Ingår i Psycho-Oncology, s. 2012-2018, 2020

Mebendazole is unique among tubulin-active drugs in activating the MEK-ERK pathway

Andersson, Claes; Selvin, Tove; Blom, Kristin; Rubin, Jenny et al.

Ingår i Scientific Reports, 2020

Effects of a nutrition intervention on acute and late bowel symptoms and health-related quality of life up to 24 months post radiotherapy in patients with prostate cancer: a multicentre randomised controlled trial.

Forslund, Marina; Ottenblad, Anna; Ginman, Claes; Johansson, Silvia et al.

Ingår i Supportive Care in Cancer, s. 3331-3342, 2020

Ultrasound-guided Percutaneous Irreversible Electroporation for Treatment of Locally Recurrent Pancreatic Cancer After Surgical Resection

Månsson, Christopher; Nilsson, Anders; Nygren, Peter; Karlson, Britt-Marie

Ingår i Anticancer Research, s. 2771-2775, 2020

DOI för Ultrasound-guided Percutaneous Irreversible Electroporation for Treatment of Locally Recurrent Pancreatic Cancer After Surgical Resection

Experiences of a nutrition intervention: A qualitative study within a randomised controlled trial in men undergoing radiotherapy for prostate cancer

Forslund, Marina; Nygren, Peter; Ottenblad, Anna; Johansson, Birgitta

Ingår i Nutrition & Dietetics, s. 223-230, 2020

DOI för Experiences of a nutrition intervention: A qualitative study within a randomised controlled trial in men undergoing radiotherapy for prostate cancer

Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition

Blom, Kristin; Eriksson, Jenny; Berglund, Malin; Jarvius, Malin et al.

Ingår i BMC Research Notes, 2019

A phase I study of the safety and tolerability of VLX600, an Iron Chelator, in patients with refractory advanced solid tumors

Mody, Kabir; Mansfield, Aaron S.; Vemireddy, Lalitha; Nygren, Peter et al.

Ingår i Investigational new drugs, s. 684-692, 2019

DOI för A phase I study of the safety and tolerability of VLX600, an Iron Chelator, in patients with refractory advanced solid tumors

Percutaneous Irreversible Electroporation as First Line Treatment of Locally Advanced Pancreatic Cancer

Månsson, Christopher; Brahmstaedt, Richard; Nygren, Peter; Nilsson, Anders et al.

Ingår i Anticancer Research, s. 2509-2512, 2019

DOI för Percutaneous Irreversible Electroporation as First Line Treatment of Locally Advanced Pancreatic Cancer

Lessons learned from the maturation of a cancer drug: oxaliplatin in colorectal cancer

Glimelius, Bengt; Nygren, Peter

Ingår i Acta Oncologica, s. 395-397, 2019

DOI för Lessons learned from the maturation of a cancer drug: oxaliplatin in colorectal cancer

U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden.

Glimelius, Bengt; Melin, Beatrice; Enblad, Gunilla; Alafuzoff, Irina et al.

Ingår i Acta Oncologica, s. 187-194, 2018

Ex vivo activity of cytotoxic drugs and targeted agents in small intestinal neuroendocrine tumors

Daskalakis, Kosmas; Norlén, Olov; Karakatsanis, Andreas; Hellman, Per et al.

Ingår i Endocrine-Related Cancer, s. 471-480, 2018

DOI för Ex vivo activity of cytotoxic drugs and targeted agents in small intestinal neuroendocrine tumors

Ex Vivo Activity of Cytotoxic Drugs and Targeted Agents in Small Intestinal Neuroendocrine Tumors

Daskalakis, Kosmas; Norlén, Olov; Karakatsanis, Andreas; Hellman, Per et al.

Ingår i Neuroendocrinology, s. 189-189, 2018

DOI för Ex Vivo Activity of Cytotoxic Drugs and Targeted Agents in Small Intestinal Neuroendocrine Tumors

Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects.

Eriksson, Anna; Chantzi, Efthymia; Fryknäs, Mårten; Gullbo, Joachim et al.

Ingår i Leukemia Research, s. 41-46, 2017

Bliss and Loewe interaction analyses of clinically relevant drug combinations in human colon cancer cell lines reveal complex patterns of synergy and antagonism

Kashif, Muhammad; Andersson, Claes; Mansoori, Sharmineh; Larsson, Rolf et al.

Ingår i Oncotarget, s. 103952-103967, 2017

Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity

Karlsson, Henning; Fryknäs, Mårten; Strese, Sara; Gullbo, Joachim et al.

Ingår i Oncotarget, s. 30217-30234, 2017

Prognostic factors in patients with loco-regionally advanced gastric cancer

Hultman, Bo; Gunnarsson, Ulf; Nygren, Peter; Sundbom, Magnus et al.

Ingår i World Journal of Surgical Oncology, 2017

The development of a Nurse-led Internet-based Learning and Self-care program for cancer patients with symptoms of anxiety and depression: a part of U-CARE

Hauffman, Anna; Alfonsson, Sven; Mattson, Susanne; Forslund, Marina et al.

Ingår i Cancer Nursing, 2017

Targeting tumor cells based on Phosphodiesterase 3A expression

Nazir, Madiha; Senkowski, Wojciech; Nyberg, Frida; Blom, Kristin et al.

Ingår i Experimental Cell Research, s. 308-315, 2017

DOI för Targeting tumor cells based on Phosphodiesterase 3A expression

The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation

Blom, Kristin; Senkowski, Wojciech; Jarvius, Malin; Berglund, Malin et al.

Ingår i Immunopharmacology and immunotoxicology, s. 199-210, 2017

DOI för The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation

Predictive Value of Ex Vivo Chemosensitivity Assays for Individualized Cancer Chemotherapy: A Meta-Analysis

Blom, Kristin; Nygren, Peter; Larsson, Rolf; Andersson, Claes R.

Ingår i SLAS TECHNOLOGY, s. 306-314, 2017

DOI för Predictive Value of Ex Vivo Chemosensitivity Assays for Individualized Cancer Chemotherapy: A Meta-Analysis

High sensitivity isoelectric focusing to establish a signaling biomarker for the diagnosis of human colorectal cancer

Padhan, Narendra; Nordling, Torbjorn E. M.; Sundström, Magnus; Åkerud, Peter et al.

Ingår i BMC Cancer, 2016

Preclinical activity of melflufen (J1) in ovarian cancer

Carlier, Charlotte; Strese, Sara; Viktorsson, Kristina; Velander, Ebba et al.

Ingår i Oncotarget, s. 59322-59335, 2016

DOI för Preclinical activity of melflufen (J1) in ovarian cancer

Iron chelators target both proliferating and quiescent cancer cells

Fryknäs, Mårten; Zhang, Xiaonan; Bremberg, Ulf; Senkowski, Wojciech et al.

Ingår i Scientific Reports, 2016

Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids

Senkowski, Wojciech; Jarvius, Malin; Rubin, Jenny; Lengqvist, Johan et al.

Ingår i CELL CHEMICAL BIOLOGY, s. 1428-1438, 2016

DOI för Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids

Percutaneous irreversible electroporation for treatment of locally advanced pancreatic cancer following chemotherapy or radiochemotherapy

Månsson, Christopher; Brahmstaedt, Richard; Nilsson, Anders; Nygren, Peter et al.

Ingår i European Journal of Surgical Oncology, s. 1401-1406, 2016

DOI för Percutaneous irreversible electroporation for treatment of locally advanced pancreatic cancer following chemotherapy or radiochemotherapy

Differences in trial knowledge and motives for participation among cancer patients in phase 3 clinical trials

Godskesen, Tove; Kihlbom, Ulrik; Nordin, Karin; Silen, Marit et al.

Ingår i European Journal of Cancer Care, s. 516-523, 2016

DOI för Differences in trial knowledge and motives for participation among cancer patients in phase 3 clinical trials

Oxaliplatin added to fluoropyrimidine for adjuvant treatment of colorectal cancer is associated with long-term impairment of peripheral nerve sensory function and quality of life

Stefansson, Måns; Nygren, Peter

Ingår i Acta Oncologica, s. 1227-1235, 2016

DOI för Oxaliplatin added to fluoropyrimidine for adjuvant treatment of colorectal cancer is associated with long-term impairment of peripheral nerve sensory function and quality of life

Repositioning Of Quinacrine For Treatment Of Acute Myeloid Leukemia - Synergies And In Vivo Effects

Eriksson, Anna; Gustafsson, Mats; Fryknäs, Mårten; Gullbo, Joachim et al.

Ingår i Haematologica, s. 367-368, 2016

Uptake, delivery, and anticancer activity of thymoquinone nanoparticles in breast cancer cells

Fakhoury, Isabelle; Saad, Walid; Bouhadir, Kamal; Nygren, Peter et al.

Ingår i Journal of nanoparticle research, 2016

DOI för Uptake, delivery, and anticancer activity of thymoquinone nanoparticles in breast cancer cells

Ex Vivo Assessment of Drug Activity in Patient Tumor Cells as a Basis for Tailored Cancer Therapy

Blom, Kristin; Nygren, Peter; Alvarsson, Jonathan; Larsson, Rolf et al.

Ingår i JALA, s. 178-187, 2016

DOI för Ex Vivo Assessment of Drug Activity in Patient Tumor Cells as a Basis for Tailored Cancer Therapy

Label free quantification of time evolving morphologies using time-lapse video microscopy enables identity control of cell lines and discovery of chemically induced differential activity in iso-genic cell line pairs

Aftab, Obaid; Fryknäs, Mårten; Hassan, Saadia; Nygren, Peter et al.

Ingår i Chemometrics and Intelligent Laboratory Systems, s. 24-32, 2015

DOI för Label free quantification of time evolving morphologies using time-lapse video microscopy enables identity control of cell lines and discovery of chemically induced differential activity in iso-genic cell line pairs

Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

Senkowski, Wojciech; Zhang, Xiaonan; Olofsson, Maria Hagg; Isacson, Ruben et al.

Ingår i Molecular Cancer Therapeutics, s. 1504-1516, 2015

DOI för Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

Spheroid-based high throughput screening for identification of molecules targeting different tumor microenvironment characteristics

Senkowski, Wojciech; Zhang, Xiaonan; Nygren, Peter; Olofsson, Maria Hagg et al.

Ingår i Cancer Research, 2015

DOI för Spheroid-based high throughput screening for identification of molecules targeting different tumor microenvironment characteristics

Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia

Eriksson, Anna; Österroos, Albin; Hassan, Sadia Bashir; Gullbo, Joachim et al.

Ingår i Blood Cancer Journal, 2015

In vitro discovery of promising anti-cancer drug combinations using iterative maximisation of a therapeutic index

Kashif, Muhammad; Andersson, Claes; Hassan, Sadia; Karlsson, Henning et al.

Ingår i Scientific Reports, 2015

Hope for a cure and altruism are the main motives behind participation in phase 3 clinical cancer trials

Godskesen, Tove; Hansson, Mats G.; Nygren, Peter; Nordin, Karin et al.

Ingår i European Journal of Cancer Care, s. 133-141, 2015

DOI för Hope for a cure and altruism are the main motives behind participation in phase 3 clinical cancer trials

Drug Sensitivity Testing in Cytoreductive Surgery and Intraperitoneal Chemotherapy of Pseudomyxoma Peritonei

Bjersand, Kathrine; Mahteme, Haile; Sundström Poromaa, Inger; Andreasson, Håkan et al.

Ingår i Annals of Surgical Oncology, 2015

DOI för Drug Sensitivity Testing in Cytoreductive Surgery and Intraperitoneal Chemotherapy of Pseudomyxoma Peritonei

First-in-human, phase I/IIa clinical study of the peptidase potentiated alkylator melflufen administered every three weeks to patients with advanced solid tumor malignancies

Berglund, Åke; Ullen, Anders; Lisyanskaya, Alla; Orlov, Sergey et al.

Ingår i Investigational new drugs, s. 1232-1241, 2015

DOI för First-in-human, phase I/IIa clinical study of the peptidase potentiated alkylator melflufen administered every three weeks to patients with advanced solid tumor malignancies

Always look at the bright side of drugs?

Nygren, Peter

Ingår i Acta Oncologica, s. 145-147, 2015

DOI för Always look at the bright side of drugs?

Considerations on the Selection Process for Cytoreductive Surgery and Hyperthermic IntraPeritoneal Chemotherapy for Colorectal Carcinomatosis Reply

Cashin, Peter; Graf, Wilhelm; Nygren, Peter; Mahteme, Haile

Ingår i Annals of Surgery, 2015

O-15-Water PET Study of the Effect of Imatinib, a Selective Platelet-Derived Growth Factor Receptor Inhibitor, Versus Anakinra, an IL-1R Antagonist, on Water-Perfusable Tissue Fraction in Colorectal Cancer Metastases

Lubberink, Mark; Golla, Sanjeep S. V.; Jonasson, My; Rubin, Kristofer et al.

Ingår i Journal of Nuclear Medicine, s. 1144-1149, 2015

DOI för O-15-Water PET Study of the Effect of Imatinib, a Selective Platelet-Derived Growth Factor Receptor Inhibitor, Versus Anakinra, an IL-1R Antagonist, on Water-Perfusable Tissue Fraction in Colorectal Cancer Metastases

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Zhang, Xiaonan; Fryknäs, Mårten; Hernlund, Emma; Fayad, Walid et al.

Ingår i Nature Communications, s. 3295, 2014

Benchmarking of gastric cancer sensitivity to anti-cancer drugs ex vivo as a basis for drug selection in systemic and intraperitoneal therapy

Hultman, Bo; Mahteme, Haile; Sundbom, Magnus; Ljungman, Martin et al.

Ingår i Journal of Experimental & Clinical Cancer Research, 2014

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Zhang, Xiaonan; Fryknäs, Mårten; Hernlund, Emma; Fayad, Walid et al.

Ingår i Nature Communications, s. 3295, 2014

Effects of a dietary intervention on gastrointestinal symptoms after prostate cancer radiotherapy: Long-term results from a randomized controlled trial

Pettersson, Anna; Nygren, Peter; Persson, Christina; Berglund, Anders et al.

Ingår i Radiotherapy and Oncology, s. 240-247, 2014

DOI för Effects of a dietary intervention on gastrointestinal symptoms after prostate cancer radiotherapy: Long-term results from a randomized controlled trial

Chemotherapeutic drug sensitivity of primary cultures of epithelial ovarian cancer cells from patients in relation to tumour characteristics and therapeutic outcome

von Heideman, Anne; Tholander, Bengt; Grundmark, Birgitta; Cajander, Stefan et al.

Ingår i Acta Oncologica, s. 242-250, 2014

DOI för Chemotherapeutic drug sensitivity of primary cultures of epithelial ovarian cancer cells from patients in relation to tumour characteristics and therapeutic outcome

Safety and Preliminary Efficacy of Ultrasound-guided Percutaneous Irreversible Electroporation for Treatment of Localized Pancreatic Cancer

Månsson, Christopher; Bergenfeldt, Magnus; Brahmstaedt, Richard; Karlson, Britt-Marie et al.

Ingår i Anticancer Research, s. 289-293, 2014

A Pragmatic Definition of Therapeutic Synergy Suitable for Clinically Relevant In Vitro Multicompound Analyses

Kashif, Muhammad; Andersson, Claes; Åberg, Magnus; Nygren, Peter et al.

Ingår i Molecular Cancer Therapeutics, s. 1964-1976, 2014

DOI för A Pragmatic Definition of Therapeutic Synergy Suitable for Clinically Relevant In Vitro Multicompound Analyses

Repositioning of Quinacrine for Treatment of Acute Myeloid Leukemia

Eriksson, Anna; Osterros, Albin; Hassan, Sadia Bashir; Gullbo, Joachim et al.

Ingår i Blood, 2014

Activity ex vivo of cytotoxic drugs in patient samples of peritoneal carcinomatosis with special focus on colorectal cancer

Cashin, Peter H; Mahteme, Haile; Graf, Wilhelm; Karlsson, Henning et al.

Ingår i BMC Cancer, s. 435, 2013

Internet-based stepped care with interactive support and cognitive behavioral therapy for reduction of anxiety and depressive symptoms in cancer: a clinical trial protocol

Mattsson, Susanne; Alfonsson, Sven; Carlsson, Maria; Nygren, Peter et al.

Ingår i BMC Cancer, s. 414, 2013

Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance

Fryknäs, Mårten; Gullbo, Joachim; Wang, Xin; Rickardson, Linda et al.

Ingår i BMC Cancer, s. 374, 2013

Phase 1 clinical trials in end-stage cancer: patient understanding of trial premises and motives for participation

Godskesen, Tove; Nygren, Peter; Nordin, Karin; Hansson, Mats et al.

Ingår i Supportive Care in Cancer, s. 3137-3142, 2013

DOI för Phase 1 clinical trials in end-stage cancer: patient understanding of trial premises and motives for participation

Phase II study of patients with peritoneal carcinomatosis from gastric cancer treated with preoperative systemic chemotherapy followed by peritonectomy and intraperitoneal chemotherapy

Hultman, Bo; Lind, Pehr; Glimelius, Bengt; Sundbom, Magnus et al.

Ingår i Acta Oncologica, s. 824-830, 2013

DOI för Phase II study of patients with peritoneal carcinomatosis from gastric cancer treated with preoperative systemic chemotherapy followed by peritonectomy and intraperitoneal chemotherapy

Comparison of Prognostic Scores for Patients with Colorectal Cancer Peritoneal Metastases Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy

Cashin, Peter H.; Graf, Wilhelm; Nygren, Peter; Mahteme, Haile

Ingår i Annals of Surgical Oncology, s. 4183-4189, 2013

DOI för Comparison of Prognostic Scores for Patients with Colorectal Cancer Peritoneal Metastases Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy

Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells

Jarvius, Malin; Fryknäs, Mårten; D'Arcy, Padraig; Sun, Chao et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 117-123, 2013

DOI för Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells

The Nanoparticulate Quillaja Saponin BBE Is Selectively Active Towards Renal Cell Carcinoma

Hassan, Saadia Bashir; Gullbo, Joachim; Hu, Kefei; Berenjian, Saideh et al.

Ingår i Anticancer Research, s. 143-151, 2013

Pharmacokinetics of cisplatin during hyperthermic intraperitoneal treatment of peritoneal carcinomatosis

Cashin, Peter H; Ehrsson, H; Wallin, I; Nygren, Peter et al.

Ingår i European Journal of Clinical Pharmacology, s. 533-540, 2013

DOI för Pharmacokinetics of cisplatin during hyperthermic intraperitoneal treatment of peritoneal carcinomatosis

Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer

Nygren, Peter; Fryknäs, Mårten; Anagel, Bengt; Larsson, Rolf

Ingår i Journal of Cancer Research and Clinical Oncology, s. 2133-2140, 2013

Loss of cancer drug activity in colon cancer HCT-116 cells during spheroid formation in a new 3-D spheroid cell culture system

Karlsson, Henning; Fryknäs, Mårten; Larsson, Rolf; Nygren, Peter

Ingår i Experimental Cell Research, s. 1577-1585, 2012

DOI för Loss of cancer drug activity in colon cancer HCT-116 cells during spheroid formation in a new 3-D spheroid cell culture system

The effect of a dimeric Affibody molecule (ZEGFR:1907)2 targeting EGFR in combination with radiation in colon cancer cell lines

Häggblad Sahlberg, Sara; Spiegelberg, Diana; Lennartsson, Johan; Nygren, Peter et al.

Ingår i International Journal of Oncology, s. 176-184, 2012

Histopathological Classification of Pseudomyxoma Peritonei and the Prognostic Importance of PINCH Protein

Andreasson, Håkan; Wanders, Alkwin; Sun, Xiao-Feng; Willén, Roger et al.

Ingår i Anticancer Research, s. 1443-1448, 2012

In vitro evaluation of clinical activity and toxicity of anticancer drugs using tumor cells from patients and cells representing normal tissues

Haglund, Caroline; Åleskog, Anna; Nygren, Peter; Gullbo, Joachim et al.

Ingår i Cancer Chemotherapy and Pharmacology, s. 697-707, 2012

DOI för In vitro evaluation of clinical activity and toxicity of anticancer drugs using tumor cells from patients and cells representing normal tissues

Intraoperative hyperthermic versus postoperative normothermic intraperitoneal chemotherapy for colonic peritoneal carcinomatosis: a case-control study

Cashin, Peter H; Graf, Wilhelm; Nygren, Peter; Mahteme, Haile

Ingår i Annals of Oncology, s. 647-652, 2012

Costs and clinical outcome of neoadjuvant systemic chemotherapy followed by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in peritoneal carcinomatosis from gastric cancer

Hultman, Bo; Lundkvist, Jonas; Glimelius, Bengt; Nygren, Peter et al.

Ingår i Acta Oncologica, s. 112-121, 2012

DOI för Costs and clinical outcome of neoadjuvant systemic chemotherapy followed by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in peritoneal carcinomatosis from gastric cancer

Patient Selection for Cytoreductive Surgery in Colorectal Peritoneal Carcinomatosis using Serum Tumour Markers – an Observational Cohort Study

Cashin, Peter H; Graf, Wilhelm; Nygren, Peter; Mahteme, Haile

Ingår i Annals of Surgery, s. 1078-1083, 2012

DOI för Patient Selection for Cytoreductive Surgery in Colorectal Peritoneal Carcinomatosis using Serum Tumour Markers – an Observational Cohort Study

The initial change in tumor size predicts response and survival in patients with metastatic colorectal cancer treated with combination chemotherapy

Suzuki, C; Blomqvist, L; Sundin, Anders; Jacobsson, H et al.

Ingår i Annals of Oncology, s. 948-954, 2012

DOI för The initial change in tumor size predicts response and survival in patients with metastatic colorectal cancer treated with combination chemotherapy

Cytoreductive Surgery and Intraperitoneal Chemotherapy for Colorectal Peritoneal Carcinomatosis: Prognosis and Treatment of Recurrences in a Cohort Study

Cashin, Peter H; Graf, Wilhelm; Nygren, Peter; Mahteme, Haile

Ingår i European Journal of Surgical Oncology, s. 509-515, 2012

Quantitative accuracy of parametric myocardial and tumour blood flow images based on HYPR-LR-filtered dynamic [O-15]water PET

Golla, Sandeep; Sörensen, Jens; Kero, Tanja; Harms, H. et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2012

Outcome differences between debulking surgery and cytoreductive surgery in patients with pseudomyxoma peritonei

Andréasson, Håkan; Graf, Wilhelm; Nygren, Peter; Glimelius, Bengt et al.

Ingår i European Journal of Surgical Oncology, s. 962-968, 2012

DOI för Outcome differences between debulking surgery and cytoreductive surgery in patients with pseudomyxoma peritonei

Evaluation of predictive markers for patients with advanced colorectal cancer

Byström, Per; Berglund, Åke; Nygren, Peter; Wernroth, Lisa et al.

Ingår i Acta Oncologica, s. 849-859, 2012

DOI för Evaluation of predictive markers for patients with advanced colorectal cancer

Response to comments on 'Cytoreductive surgery and intraperitoneal chemotherapy'

Cashin, Peter H.; Graf, Wilhelm; Nygren, Peter; Mahteme, Haile

Ingår i European Journal of Surgical Oncology, s. 1012-1012, 2012

DOI för Response to comments on 'Cytoreductive surgery and intraperitoneal chemotherapy'

Pseudomyxoma Peritone: symptoms, treatment, prognosis and sensitivity to cytostatic drugs in vitro

Bjersand, Kathrine; Poromaa, Inger Sundström; Nygren, Peter; Mahteme, Haile

Ingår i Acta Obstetricia et Gynecologica Scandinavica, s. 71-71, 2012

DOI för Pseudomyxoma Peritone: symptoms, treatment, prognosis and sensitivity to cytostatic drugs in vitro

Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment

Gullbo, Joachim; Fryknäs, Mårten; Rickardson, Linda; Darcy, Padraig et al.

Ingår i Biochemical Pharmacology, s. 139-147, 2011

DOI för Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment

EGFR, HER2 and HER3 expression in primary colorectal carcinomas and corresponding metastases: Implications for targeted radionuclide therapy

Wei, Q.; Shui, Y.; Zheng, S.; Wester, Kenneth et al.

Ingår i Oncology Reports, s. 3-11, 2011

DOI för EGFR, HER2 and HER3 expression in primary colorectal carcinomas and corresponding metastases: Implications for targeted radionuclide therapy

Novel activity of acriflavine against colorectal cancer tumor cells

Hassan, Saadia; Laryea, Daniel; Mahteme, Haile; Felth, Jenny et al.

Ingår i Cancer Science, s. 2206-2213, 2011

DOI för Novel activity of acriflavine against colorectal cancer tumor cells

Appendiceal Adenocarcinoids with Peritoneal Carcinomatosis Treated with Cytoreductive Surgery and Intraperitoneal Chemotherapy: a retrospective study of in vitro drug sensitivity and survival

Cashin, Peter; Nygren, Peter; Hellman, Per; Granberg, Dan et al.

Ingår i Clinical Colorectal Cancer, s. 108-112, 2011

DOI för Appendiceal Adenocarcinoids with Peritoneal Carcinomatosis Treated with Cytoreductive Surgery and Intraperitoneal Chemotherapy: a retrospective study of in vitro drug sensitivity and survival

An explorative randomised phase II study of sequential chemotherapy in advanced upper gastrointestinal cancer

Berglund, Åke; Byström, Per; Johansson, Birgitta; Nygren, Peter et al.

Ingår i Medical Oncology, s. 65-72, 2010

DOI för An explorative randomised phase II study of sequential chemotherapy in advanced upper gastrointestinal cancer

An explorative study on the clinical utility of baseline and serial serum tumour marker measurements in advanced upper gastrointestinal cancer

Byström, P.; Berglund, Åke; Nygren, Peter; Wernroth, Mona-Lisa et al.

Ingår i Oncology Reports, s. 1645-1652, 2010

DOI för An explorative study on the clinical utility of baseline and serial serum tumour marker measurements in advanced upper gastrointestinal cancer

Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published data

von Heideman, Anne; Berglund, Åke; Larsson, Rolf; Nygren, Peter

Ingår i Cancer Chemotherapy and Pharmacology, s. 1165-1172, 2010

DOI för Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published data

Characterization of the cytotoxic properties of the benzimidazole fungicides, benomyl and carbendazim, in human tumour cell lines and primary cultures of patient tumour cells

Laryea, Daniel; Gullbo, Joachim; Isaksson, Anders; Larsson, Rolf et al.

Ingår i Anti-Cancer Drugs, s. 33-42, 2010

DOI för Characterization of the cytotoxic properties of the benzimidazole fungicides, benomyl and carbendazim, in human tumour cell lines and primary cultures of patient tumour cells

Nanoparticulate Quillaja saponin induces apoptosis in human leukemia cell lines with a high therapeutic index

Hu, Kefei; Berenjian, Saideh; Larsson, Rolf; Gullbo, Joachim et al.

Ingår i International Journal of Nanomedicine, s. 51-62, 2010

Early prediction of response to first-line chemotherapy by sequential [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography in patients with advanced colorectal cancer

Byström, Per; Berglund, A.; Garske, Ulrike Garske; Jacobsson, H. et al.

Ingår i Annals of Oncology, s. 1057-1061, 2009

DOI för Early prediction of response to first-line chemotherapy by sequential [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography in patients with advanced colorectal cancer

In vitro activity of bortezomib in cultures of patient tumour cells-potential utility in haematological malignancies

Wiberg, Kristina; Carlson, Kristina; Åleskog, Anna; Larsson, Rolf et al.

Ingår i Medical Oncology, s. 193-201, 2009

DOI för In vitro activity of bortezomib in cultures of patient tumour cells-potential utility in haematological malignancies

Characterization of the cytotoxic activity of the indoloquinoline alkaloid cryptolepine in human tumour cell lines and primary cultures of tumour cells from patients

Laryea, Daniel; Isaksson, Anders; Wright, Colin; Larsson, Rolf et al.

Ingår i Investigational new drugs, s. 402-411, 2009

DOI för Characterization of the cytotoxic activity of the indoloquinoline alkaloid cryptolepine in human tumour cell lines and primary cultures of tumour cells from patients

Postoperative adverse events and long-term survival after cytoreductive surgery and intraperitoneal chemotherapy

Hansson, Johan; Graf, Wilhelm; Påhlman, Lars; Nygren, Peter et al.

Ingår i European Journal of Surgical Oncology, s. 202-208, 2009

DOI för Postoperative adverse events and long-term survival after cytoreductive surgery and intraperitoneal chemotherapy

Radiological assessment of tumour response to anti-cancer drugs: time to reappraise

Nygren, Peter; Blomqvist, Lennart; Bergh, Jonas; Åström, Gunnar

Ingår i Acta Oncologica, s. 316-8, 2008

DOI för Radiological assessment of tumour response to anti-cancer drugs: time to reappraise

Är du ung så ska du få, men är du gammal så får du gå. Om ålderns betydelse för terapival och prioriteringar vid cancer

Nygren, Peter; Sandman, Lars

Ingår i Läkartidningen, s. 3417-9, 2008

Significant cytotoxic activity in vitro of the EGFR tyrosine kinase inhibitor gefitinib in acute myeloblastic leukaemia

Lindhagen, Elin; Eriksson, Anna; Wickström, Malin; Danielsson, Katarina et al.

Ingår i European Journal of Haematology, s. 344-353, 2008

DOI för Significant cytotoxic activity in vitro of the EGFR tyrosine kinase inhibitor gefitinib in acute myeloblastic leukaemia

The fluorometric microculture cytotoxicity assay

Lindhagen, Elin; Nygren, Peter; Larsson, Rolf

Ingår i Nature Protocols, s. 1364-1369, 2008

DOI för The fluorometric microculture cytotoxicity assay

Rapamycin shows anticancer activity in primary chronic lymphocytic leukemia cells in vitro, as single agent and in drug combination

Åleskog, Anna; Norberg, Maria; Nygren, Peter; Rickardson, Linda et al.

Ingår i Leukemia and Lymphoma, s. 2333-2343, 2008

DOI för Rapamycin shows anticancer activity in primary chronic lymphocytic leukemia cells in vitro, as single agent and in drug combination

The novel alkylating prodrug J1: diagnosis directed activity profile ex vivo and combination analyses in vitro

Wickström, Malin; Haglund, Caroline; Lindman, Henrik; Nygren, Peter et al.

Ingår i Investigational new drugs, s. 195-204, 2008

DOI för The novel alkylating prodrug J1: diagnosis directed activity profile ex vivo and combination analyses in vitro

Heterogeneous activity of cytotoxic drugs in patient samples of peritoneal carcinomatosis

Mahteme, Haile; von Heideman, Anne; Grundmark, Birgitta; Tholander, B. et al.

Ingår i European Journal of Surgical Oncology, s. 547-552, 2008

DOI för Heterogeneous activity of cytotoxic drugs in patient samples of peritoneal carcinomatosis

STAT1 signaling is associated with acquired crossresistance to doxorubicin and radiation in myeloma cell lines

Fryknäs, Mårten; Dhar, Sumeer; Öberg, Fredrik; Rickardson, Linda et al.

Ingår i International Journal of Cancer, s. 189-195, 2007

DOI för STAT1 signaling is associated with acquired crossresistance to doxorubicin and radiation in myeloma cell lines

Modeling of in vitro drug activity and prediction of clinical outcome in acute myeloid leukemia

Quartino, Angelica; Karlsson, Mats O.; Freijs, Agneta; Jonsson, Niclas et al.

Ingår i Journal of clinical pharmacology, s. 1014-1021, 2007

DOI för Modeling of in vitro drug activity and prediction of clinical outcome in acute myeloid leukemia

Pharmacological profiling of novel non-COX-inhibiting indole-pyran analogues of etodolac reveals high solid tumour activity of SDX-308 in vitro

Lindhagen, Elin; Rickardson, Linda; Elliott, Gary; Leoni, Lorenzo et al.

Ingår i Investigational new drugs, s. 297-303, 2007

DOI för Pharmacological profiling of novel non-COX-inhibiting indole-pyran analogues of etodolac reveals high solid tumour activity of SDX-308 in vitro

Individually tailored toxicity-based 5-fluorouracil, epirubicin and cyclophosphamide (FEC) therapy of metastatic breast cancer

Lindman, Henrik; Åström, Gunnar; Ahlgren, Johan; Villman, Kenneth et al.

Ingår i Acta Oncologica, s. 165-171, 2007

DOI för Individually tailored toxicity-based 5-fluorouracil, epirubicin and cyclophosphamide (FEC) therapy of metastatic breast cancer

The pharmacist and quality of cancer chemotherapy.

Nygren, Peter

Ingår i Acta Oncologica, s. 715-716, 2007

DOI för The pharmacist and quality of cancer chemotherapy.

Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients

Wickström, Malin; Danielsson, Katarina; Rickardson, Linda; Gullbo, Joachim et al.

Ingår i Biochemical Pharmacology, s. 25-33, 2007

DOI för Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients

Inhibition of proteasome activity, nuclear factor-KB translocation and cell survival by the antialcoholism drug disulfiram

Lövborg, Henrik; Öberg, Fredrik; Rickardson, Linda; Gullbo, Joachim et al.

Ingår i International Journal of Cancer, s. 1577-1580, 2006

DOI för Inhibition of proteasome activity, nuclear factor-KB translocation and cell survival by the antialcoholism drug disulfiram

Screening of an annotated compound library for drug activity in a resistant myeloma cell line

Rickardson, Linda; Fryknäs, Mårten; Haglund, Caroline; Lövborg, Henrik et al.

Ingår i Cancer Chemotherapy and Pharmacology, s. 749-758, 2006

DOI för Screening of an annotated compound library for drug activity in a resistant myeloma cell line

Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model

Fryknäs, Mårten; Rickardson, Linda; Wickström, Malin; Dhar, Sumeer et al.

Ingår i Journal of Biomolecular Screening, s. 457-468, 2006

DOI för Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model

Accuracy of assessment of distress, anxiety, and depression by physicians and nurses in adolescents recently diagnosed with cancer

Hedström, Mariann; Kreuger, Anders; Ljungman, Gustaf; Nygren, Peter et al.

Ingår i Pediatric Blood & Cancer, s. 773-9, 2006

DOI för Accuracy of assessment of distress, anxiety, and depression by physicians and nurses in adolescents recently diagnosed with cancer

Impact of fish oil and melatonin on cachexia in patients with advanced gastrointestinal cancer: a randomized pilot study.

Persson, Christina; Glimelius, Bengt; Rönnelid, Johan; Nygren, Peter

Ingår i Nutrition, s. 170-8, 2005

Translocation t(1;19) is related to low cellular drug resistance in childhood acute lymphoblastic leukaemia

Frost, B M; Forestier, E; Gustafsson, G; Nygren, Peter et al.

Ingår i Leukemia, s. 165-169, 2005

DOI för Translocation t(1;19) is related to low cellular drug resistance in childhood acute lymphoblastic leukaemia

Model describing the relationship between pharmacokinetics and hematologic toxicity of the epirubicin-docetaxel regimen in breast cancer patients.

Sandström, M; Lindman, Henrik; Nygren, Peter; Lidbrink, E et al.

Ingår i J Clin Oncol, s. 413-21, 2005

Cellular drug sensitivity in MLL-rearranged childhood acute leukaemia is correlated to partner genes and cell lineage.

Palle, J; Frost, B M; Forestier, E; Gustafsson, G et al.

Ingår i Br J Haematol, s. 189-98, 2005

[Limit investigation in cancer of unknown primary site]

Berglund, Ake; Nygren, Peter; Hagberg, Hans; Pahlman, Lars et al.

Ingår i Lakartidningen, s. 2946-8, 2950, 2005

Lack of effect of aprepitant on the pharmacokinetics of docetaxel in cancer patients.

Nygren, Peter; Hande, Kenneth; Petty, Kevin J; Fedgchin, Margaret et al.

Ingår i Cancer Chemother Pharmacol, s. 609-16, 2005

Predictive value of in vitro assessment of cytotoxic drug activity in advanced breast cancer.

Villman, Kenneth; Blomqvist, Carl; Larsson, Rolf; Nygren, Peter

Ingår i Anticancer Drugs, s. 609-15, 2005

In vitro drug resistance in B cell chronic lymphocytic leukemia: a comparison with acute myelocytic and acute lymphocytic leukemia.

Åleskog, Anna; Larsson, Rolf; Höglund, Martin; Kristensen, Jörgen et al.

Ingår i Anticancer Drugs, s. 277-83, 2005

Identification of molecular mechanisms for cellular drug resistance by combining drug activity and gene expression profiles

Rickardson, Linda; Fryknäs, Mårten; Dhar, Sumeer; Lövborg, Henrik et al.

Ingår i British Journal of Cancer, s. 483-492, 2005

Translocation t(12;21) is related to in vitro cellular drug sensitivity to doxorubicin and etoposide in childhood acute lymphoblastic leukemia

Frost, Britt-Marie; Forestier, Erik; Gustafsson, Göran; Nygren, Peter et al.

Ingår i Blood, s. 2452-7, 2004

DOI för Translocation t(12;21) is related to in vitro cellular drug sensitivity to doxorubicin and etoposide in childhood acute lymphoblastic leukemia

Multiparametric evaluation of apoptosis: effects of standard cytotoxic agents and the cyanoguanidine CHS 828

Lövborg, Henrik; Nygren, Peter; Larsson, Rolf

Ingår i Molecular Cancer Therapeutics, s. 521-526, 2004

Antitumor efficacy and acute toxicity of the novel dipeptide melphalanyl-p-L-fluorophenylalanine ethyl ester (J1) in vivo.

Gullbo, Joachim; Lindhagen, Elin; Bashir-Hassan, Saadia; Tullberg, Marcus et al.

Ingår i Invest New Drugs, s. 411-20, 2004

Improved survival in patients with peritoneal metastases from colorectal cancer: a preliminary study.

Mahteme, H; Hansson, J; Berglund, Åke; Påhlman, Lars et al.

Ingår i Br J Cancer, s. 403-7, 2004

Development and characterization of two human tumor sublines expressing high-grade resistance to the cyanoguadine CHS 828

Gullbo, Joachim; Lövborg, Henrik; Dhar, Sumeer; Lukinius, Agneta et al.

Ingår i Anti-Cancer Drugs, s. 45-54, 2004

VH gene mutation status and cellular drug resistance in chronic lymphocytic leukemia

Åleskog, Anna; Tobin, Gerard; Laurell, Anna; Thunberg, Ulf et al.

Ingår i Eur J Haematol, s. 407-411, 2004

Cytotoxic effect in vivo and in vitro of CHS 828 on human myeloma cell lines.

Hovstadius, Peter; Lindhagen, Elin; Hassan, Sadia; Nilsson, Kenneth et al.

Ingår i Anticancer Drugs, s. 63-70, 2004

Antitumor activity of the novel melphalan containing tripeptide J3 (L-prolyl-melphalanyl-p-L-fluorophenylalanine ethyl ester): Comparison with its m-L-sarcolysin analogue P2

Gullbo, Joachim; Wallinder, Charlotta; Tullberg, Marcus; Lövborg, Henrik et al.

Ingår i Molecular Cancer Therapeutics, s. 1331-1339, 2003

Structure activity relationship for alkylating dipeptide nitrogen mustard derivatives

Gullbo, Joachim; Tullberg, Marcus; Våbeno, Jon; Ehrsson, Hans et al.

Ingår i Oncology Research, s. 113-132, 2003

Increased in vitro cellular drug resistance is related to poor outcome in high-risk childhood acute lymphoblastic leukaemia

Frost, Britt-Marie; Nygren, Peter; Gustafsson, G; Forestier, E et al.

Ingår i British Journal of Haematology, s. 376-385, 2003

DOI för Increased in vitro cellular drug resistance is related to poor outcome in high-risk childhood acute lymphoblastic leukaemia

Increased in vitro cellular drug resistance is related to poor outcome inhigh-risk childhood acute lymphoblastic leukaemia.

Frost, BM; Nygren, Peter; Gustafsson, G; Forestier, E et al.

Ingår i Br J Haematol, s. 376, 2003

Overview of the clinical efficacy of investigational anticancer drugs.

Nygren, Peter; Larsson, Rolf

Ingår i J Intern Med., s. 46, 2003

Population pharmacokinetic modelling of unbound and total plasma concentrations of paclitaxel in cancer patients.

Henningsson, A; Sparreboom, A; Sandström, M; Freijs, A et al.

Ingår i Eur J Cancer., s. 1105, 2003

Antitumor activity of the alkylating oligopeptides J1(L-melphalanyl-p-L-fluorophenylalanine ethyl ester) and P2(L-prolyl-m-L-fluorophenylalanine ethyl ester):comparison with melphalan.

Gullbo, Joachim; Dhar, Sumeer; Luthman, K; Ehrsson, H et al.

Ingår i Anticancer Drugs., s. 617, 2003

In vitro activity of the novel cytotoxic agent CHS 828 in childhood acute leukemia

Frost, Britt-Marie; Lönnerholm, Gudmar; Nygren, Peter; Larsson, Rolf et al.

Ingår i Anti-Cancer Drugs, s. 735-742, 2002

Modulation of pyridyl cyanoguanidine (CHS 828) induced cytotoxicity by 3-aminobenzamide in U-937 GTB cells.

Lövborg, Henrik; Martinsson, Petra; Gullbo, Joachim; Ekelund, Sara et al.

Ingår i Biochem Pharmacol, s. 1491, 2002

Metabolic effects of the cytotoxic guanidino-containing drug CHS 828 in human U-937 lymphoma cells.

Ekelund, Sara; Larsson, Rolf; Nygren, Peter

Ingår i Anticancer Res, s. 2269, 2002

Selection of chemotherapy by ex vivo assessment of tumor sensitivity tocytotoxic drugs: results of a clinical trial.

Berglund, A; Glimelius, B; Bergh, J; Brodin, O et al.

Ingår i Med Oncol, s. 151, 2002

The combination of the antitumoural pyridyl cyanoguanidine CHS 828 and etoposide in vitro from cytotoxic synergy to complete inhibition of apoptosis.

Martinsson, Petra; Ekelund, Sara; Nygren, Peter; Larsson, Rolf

Ingår i Br J Pharmacol, s. 568, 2002

Interactions between the new cytotoxic drug CHS 828 and amiloride and mitomycin C in a human tumour cell line and in tumour cells from patients.

Ekelund, Sara; Persson, I; Larsson, Rolf; Nygren, Peter

Ingår i Chemotherapy, s. 196, 2002

In vitro evaluation of the efficacy of idarubicin in human tumour cells from patients with low-grade non-Hodgkin´s lymphoma.

Åleskog, Anna; Jonsson, Elin; Larsson, Rolf; Nygren, Peter et al.

Ingår i Br J Haematol, s. 563, 2002

Assessment of drug activity and proliferation ex vivo for prediction ofoutcome in aggressive non-Hodgkin's lymphomas.

Ericsson, SM; Larsson, Rolf; Nygren, Peter; Sundstrom, C et al.

Ingår i Acta Oncol, s. 36, 2002

Cellular pharmacodynamics of the cytotoxic guanidino-containing drug CHS 828. Comparison with methylglyoxal-bis (guanylhydrazone).

Ekelund, Sara; Sjoholm, Å; Nygren, Peter; Binderup, L et al.

Ingår i Eur J Pharmacol, s. 39, 2001

Guanidino-containing drugs in cancer chemotherapy: biochemical and clinical pharmacology.

Ekelund, Sara; Nygren, Peter; Larsson, Rolf

Ingår i Biochem Pharmacol, s. 1183, 2001

Characteristics of etoposide induced apoptopic cell death in the U-937 human lymphoma cell line.

Martinsson, Petra; Liminga, Gunnar; Nygren, Peter; Larsson, Rolf

Ingår i Anti-Cancer Drugs, s. 699, 2001

In vivo activity of CHS 828 on hollow-fibre cultures of primary humantumour cells from patients.

Jonsson, Elin; Friberg, LE; Karlsson, MO; Hassan, Saadia B et al.

Ingår i Cancer Lett, s. 193, 2001

A hollow fiber model for in vitro studies of cytotoxic compounds: activityof the cyanoguanidine CHS 828.

Hassan, Saadia B; de la Torre, M; Nygren, Peter; Karlsson, MO et al.

Ingår i Anti-Cancer Drugs, s. 33, 2001

Cell death with atypical features induced by the novel antitumoral drug CHS 828, in human U-937 GTB cells.

Martinsson, Petra; de la Torre, M; Binderup, L; Nygren, Peter et al.

Ingår i Eur J Pharmacol, s. 181, 2001

Cellular cytotoxic drug sensitivity in children with leukemia and Down´s syndrome: an explanation differences in clinical outcome?

Frost, BM; Gustafsson, G; Nygren, Peter; Larsson, Rolf et al.

Ingår i Leukemia, 2000

Apoptosis induced by calcein acetoxymethyl ester in the human histiocytic lymphoma cell line U-937 GTB.

Liminga, Gunnar; Martinsson, Petra; Jonsson, B; Nygren, Peter et al.

Ingår i Biochem Pharmacol, s. 1751, 2000

Antitumor effect of suramin analogues in human tumour cell lines and primary cultures of tumour cells

Dhar, Sumeer; Gullbo, Joachim; Csoka, Katalin; Eriksson, E et al.

Ingår i Eur J Cancer, s. 803, 2000

Differential activity of topotecan, irinotecan and SN-38 in primary cultures of human tumor cells but not in cell lines.

Jonsson, Elin; Dhar, Sumeer; Jonsson, B; Nygren, Peter et al.

Ingår i Eur J Cancer, s. 2120, 2000

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