Ulrika Yngve

Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability

Popova, Gergana; Ladds, Marcus J. G. W.; Johansson, Lars; Saleh, Aljona et al.

Ingår i Journal of Medicinal Chemistry, s. 3915-3934, 2020

• DOI för Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability
• Ladda ner fulltext (pdf) av Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Ladds, Marcus J. G. W.; van Leeuwen, Ingeborg M. M.; Drummond, Catherine J.; Chu, Su et al.

Ingår i Nature Communications, 2018

• DOI för A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
• Ladda ner fulltext (pdf) av A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting

Fang, Xiaotian T.; Eriksson, Jonas; Antoni, Gunnar; Yngve, Ulrika et al.

Ingår i Neuropharmacology, s. 293-300, 2017

• DOI för Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting

Triazolopyrimidinones as gamma-secretase modulators: structure-activity relationship, modulator profile, and in vivo profiling

Yngve, Ulrika; Paulsen, Kim; Macsari, Istvan; Sundstrom, Marie et al.

Ingår i MedChemComm, s. 422-431, 2013

• DOI för Triazolopyrimidinones as gamma-secretase modulators: structure-activity relationship, modulator profile, and in vivo profiling

Imidazopyridine-based inhibitors of glycogen synthase kinase 3: synthesis and evaluation of amide isostere replacements of the carboxamide scaffold

Yngve, Ulrika; Söderman, Peter; Svensson, Mats; Rosqvist, Susanne et al.

Ingår i Chemistry and Biodiversity, s. 2442-2452, 2012

• DOI för Imidazopyridine-based inhibitors of glycogen synthase kinase 3: synthesis and evaluation of amide isostere replacements of the carboxamide scaffold

Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability

Popova, Gergana; Ladds, Marcus J. G. W.; Johansson, Lars; Saleh, Aljona et al.

Ingår i Journal of Medicinal Chemistry, s. 3915-3934, 2020

• DOI för Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability
• Ladda ner fulltext (pdf) av Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Ladds, Marcus J. G. W.; van Leeuwen, Ingeborg M. M.; Drummond, Catherine J.; Chu, Su et al.

Ingår i Nature Communications, 2018

• DOI för A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
• Ladda ner fulltext (pdf) av A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Automated GMP-production of α-[¹¹ C]methyl-L-tryptophan using a tracer production system (TPS)

Nordeman, Patrik; Yngve, Ulrika; Wilking, Helena; Gustavsson, Sven Åke et al.

Ingår i Journal of labelled compounds & radiopharmaceuticals, s. 1106-1109, 2018

• DOI för Automated GMP-production of α-[¹¹ C]methyl-L-tryptophan using a tracer production system (TPS)

Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting

Fang, Xiaotian T.; Eriksson, Jonas; Antoni, Gunnar; Yngve, Ulrika et al.

Ingår i Neuropharmacology, s. 293-300, 2017

• DOI för Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting

Tracing BACE: Synthesis and evaluation of beta-secretase inhibitors as ligands for PET imaging

Yngve, Ulrika; Nordeman, Patrik; Estrada, Sergio; Marklund, Niklas et al.

Ingår i Journal of labelled compounds & radiopharmaceuticals, 2015

Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability

Popova, Gergana; Ladds, Marcus J. G. W.; Johansson, Lars; Saleh, Aljona et al.

Ingår i Journal of Medicinal Chemistry, s. 3915-3934, 2020

• DOI för Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability
• Ladda ner fulltext (pdf) av Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Ladds, Marcus J. G. W.; van Leeuwen, Ingeborg M. M.; Drummond, Catherine J.; Chu, Su et al.

Ingår i Nature Communications, 2018

• DOI för A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
• Ladda ner fulltext (pdf) av A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Automated GMP-production of α-[¹¹ C]methyl-L-tryptophan using a tracer production system (TPS)

Nordeman, Patrik; Yngve, Ulrika; Wilking, Helena; Gustavsson, Sven Åke et al.

Ingår i Journal of labelled compounds & radiopharmaceuticals, s. 1106-1109, 2018

• DOI för Automated GMP-production of α-[¹¹ C]methyl-L-tryptophan using a tracer production system (TPS)

Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting

Fang, Xiaotian T.; Eriksson, Jonas; Antoni, Gunnar; Yngve, Ulrika et al.

Ingår i Neuropharmacology, s. 293-300, 2017

• DOI för Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting

Tracing BACE: Synthesis and evaluation of beta-secretase inhibitors as ligands for PET imaging

Yngve, Ulrika; Nordeman, Patrik; Estrada, Sergio; Marklund, Niklas et al.

Ingår i Journal of labelled compounds & radiopharmaceuticals, 2015

Triazolopyrimidinones as gamma-secretase modulators: structure-activity relationship, modulator profile, and in vivo profiling

Yngve, Ulrika; Paulsen, Kim; Macsari, Istvan; Sundstrom, Marie et al.

Ingår i MedChemComm, s. 422-431, 2013

• DOI för Triazolopyrimidinones as gamma-secretase modulators: structure-activity relationship, modulator profile, and in vivo profiling

Imidazopyridine-based inhibitors of glycogen synthase kinase 3: synthesis and evaluation of amide isostere replacements of the carboxamide scaffold

Yngve, Ulrika; Söderman, Peter; Svensson, Mats; Rosqvist, Susanne et al.

Ingår i Chemistry and Biodiversity, s. 2442-2452, 2012

• DOI för Imidazopyridine-based inhibitors of glycogen synthase kinase 3: synthesis and evaluation of amide isostere replacements of the carboxamide scaffold

3-Oxoisoindoline-1-carboxamides: Potent, State-Dependent Blockers of Voltage-Gated Sodium Channel Na(V)1.7 with Efficacy in Rat Pain Models

Macsari, Istvan; Besidski, Yeygeni; Csjernyik, Gabor; Nilsson, Linda I. et al.

Ingår i Journal of Medicinal Chemistry, s. 6866-6880, 2012

• DOI för 3-Oxoisoindoline-1-carboxamides: Potent, State-Dependent Blockers of Voltage-Gated Sodium Channel Na(V)1.7 with Efficacy in Rat Pain Models

Hybridisation of [Br-76]-labelled antisense oligonucleotides to Chromogranin A mRNA verified by RT-PCR

Wu, F; Lendvai, G; Yngve, U; Eriksson, B et al.

Ingår i Nuclear Medicine and Biology, s. 1073-1078, 2004

• DOI för Hybridisation of [Br-76]-labelled antisense oligonucleotides to Chromogranin A mRNA verified by RT-PCR

Microwave accelerated 68Ga-labelling of oligonucleotides

Velikyan, Irina; Lendvai, Gabor; Välilä, Maria; Roivainen, Anne et al.

Ingår i Journal of Labelled Compounds & Radiopharmaceuticals, s. 79-89, 2004

Labelling of octreotide using Br-76-prosthetic groups

Yngve, Ulrika; Khan, Tanweera Shaheena; Bergström, Mats; Långstrom, Bengt

Ingår i Journal of labelled compounds & radiopharmaceuticals, s. 561-573, 2001

• DOI för Labelling of octreotide using Br-76-prosthetic groups

Distribution of Br-76-labeled antisense oligonucleotides of different length determined ex vivo in rats

Wu, F; Yngve, U; Hedberg, E; Honda, M et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 179-186, 2000

• DOI för Distribution of Br-76-labeled antisense oligonucleotides of different length determined ex vivo in rats

Determination of specific radioactivity for Br-76-labeled compounds measuring the ratio between Br-76 and Br-79 using packed capillary liquid chromatography mass spectrometry

Forngren, B H; Yngve, U; Forngren, T; Langstrom, B

Ingår i Nuclear Medicine and Biology, s. 851-853, 2000

• DOI för Determination of specific radioactivity for Br-76-labeled compounds measuring the ratio between Br-76 and Br-79 using packed capillary liquid chromatography mass spectrometry

Synthesis of N-Succinimidyl 4-[76Br]Bromobenzoate and its Use in Conjugation Labelling of Macromolecules

Yngve, Ulrika; Hedberg, Elisabeth; Lövqvist, Anna; Tolmachev, Vladimir et al.

Ingår i Acta Chemica Scandinavica, s. 508-512, 1999

• DOI för Synthesis of N-Succinimidyl 4-[76Br]Bromobenzoate and its Use in Conjugation Labelling of Macromolecules

Compounds labelled with short-lived beta(+)-emitting radionuclides and some applications in life sciences. The importance of time as a parameter

Langstrom, B; Kihlberg, T; Bergstrom, M; Antoni, G et al.

Ingår i Acta Chemica Scandinavica, s. 651-669, 1999

• DOI för Compounds labelled with short-lived beta(+)-emitting radionuclides and some applications in life sciences. The importance of time as a parameter

Tritium labeling of a class of spirooxazaindolamines possessing analgesic properties.

Stroem, Peter; Malmquist, Jonas; Hansson, Jonas; Yngve, Ulrika et al.

Ingår i Synth. Appl. Isot. Labelled Compd., Proc. Int. Symp., 8th, s. 285-288, 2004

Synthesis of N-succinimidyl-4-[76Br]bromobenzoate and its use in labeling of amino-containing macromolecules.

Yngve, U.; Hedberg, E.; Tolmachev, V.; Langstrom, B.

Ingår i Synth. Appl. Isot. Labelled Compd. 1997, Proc. Int. Symp., 6th, s. 303-305, 1998

Preparation of azetidinotriazole compounds as gamma secretase modulators useful for treatment of Aβ-related diseases.

Besidski, Yevgeni; Yngve, Ulrika; Paulsen, Kim; Linde, Christian et al.

2014

Preparation of pyrimidinylamine compounds as gamma secretase modulators useful for treatment of Aβ-related diseases.

Besidski, Yevgeni; Yngve, Ulrika; Paulsen, Kim; Linde, Christian et al.

2014

Preparation of aminotriazole compounds as gamma secretase modulators useful for treatment of Aβ-related diseases.

Besidski, Yevgeni; Yngve, Ulrika; Paulsen, Kim; Linde, Christian et al.

2014

Preparation of 1-(4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)benzoyl)piperazine derivatives as glycogen synthase kinase 3 inhibitors.

Aahlin, Kristofer; Arvidsson, Per I.; Huerta, Fernando; Yngve, Ulrika.

2011

Preparation of imidazolyl-pyrimidine derivatives as GSK3 inhibitors.

Burrows, Jeremy; Huerta, Fernando; Lake, Fredrik; Pedersen, Torben et al.

2008

Preparation of arylimidazopyridine derivatives for use as GSK3 modulators.

Arvidsson, Per; Burrows, Jeremy; Soederman, Peter; Yngve, Ulrika.

2008

Preparation of imidazopyridinecarboxamide derivatives for use as GSK3 modulators.

Arvidsson, Per; Burrows, Jeremy; Soederman, Peter; Yngve, Ulrika.

2008

Preparation of piperazinyl quinazolines as 5-HT6 modulators.

Nordvall, Gunnar; Yngve, Ulrika.

2007

Preparation of piperazinyl quinazolines as 5-HT6 modulators.

Nordvall, Gunnar; Yngve, Ulrika.

2007

Benzoic acid derivatives as glycine receptor inhibitors, their preparation, pharmaceutical compositions, and use in therapy.

Gybaeck, Helena; Haeberlein, Markus; Jonasson, Catrin; Kihlstroem, Jacob et al.

2006

Preparation of five-membered heterocyclic compounds as mGluR5 receptor antagonists.

Wensbo, David; Xin, Tao; Stefanac, Tomislav; Arora, Jalaj et al.

2004