Margareta Hammarlund-Udenaes
Professor i farmakokinetik med farmakodynamik 99 vid Institutionen för farmaci; Farmakokinetik och Farmakodynamik; Translationell PKPD
- Telefon:
- 018-471 43 00
- Mobiltelefon:
- 070-425 04 85
- E-post:
- margareta.hammarlund-udenaes@farmbio.uu.se
- Besöksadress:
- Biomedicinskt Centrum BMC, Husargatan 3
- Postadress:
- Box 580
751 23 UPPSALA
Professor emeritus vid Institutionen för farmaci; Farmakokinetik och Farmakodynamik; Translationell PKPD
- Mobiltelefon:
- 070-425 04 85
- E-post:
- margareta.hammarlund-udenaes@uu.se
- Besöksadress:
- Biomedicinskt Centrum BMC, Husargatan 3
- Postadress:
- Box 580
751 23 UPPSALA
- Akademiska meriter:
- PhD
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Forskning
Within the area of translational PKPD we address conversion of pharmacokinetic data from the preclinical to the clinical setting. This is strongly needed for optimizing drug discovery processes and promoting efficient treatment of CNS diseases.
We are interested in brain drug delivery in relation to transport processes of both small and large molecules across the blood brain barrier (BBB), where a quantitative role of nanocarriers is specifically studied.
Using the concepts and methodologies developed for the brain we are also exploring drug distribution in the lung. This is important for the design and evaluation of lung targeted drugs which may be administered by inhalation.
For this purpose, methods are being developed to help analyzing the pharmacologically relevant unbound concentrations in brain and other tissues.
Our work also emphasizes the importance of bridging the expertise within academia and pharmaceutical industry in order to seek excellence in method development for better therapeutics treating CNS and lung disorders.
Read more at https://farmaci.uu.se/research/translational-pkpd/methodological-research/
Publikationer
Senaste publikationer
- Active CNS delivery of oxycodone in healthy and endotoxemic pigs (2024)
- Reduced oxycodone brain delivery in rats due to lipopolysaccharide-induced inflammation (2024)
- Region-independent active CNS net uptake of marketed H+/ OC antiporter system substrates (2024)
- Formulation-dependent differences in paclitaxel distribution to anatomical sites relevant to chemotherapy-induced peripheral neuropathy (2024)
- Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy (2024)
Alla publikationer
Artiklar
- Active CNS delivery of oxycodone in healthy and endotoxemic pigs (2024)
- Reduced oxycodone brain delivery in rats due to lipopolysaccharide-induced inflammation (2024)
- Region-independent active CNS net uptake of marketed H+/ OC antiporter system substrates (2024)
- Formulation-dependent differences in paclitaxel distribution to anatomical sites relevant to chemotherapy-induced peripheral neuropathy (2024)
- Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy (2024)
- Active Uptake of Oxycodone at Both the Blood-Cerebrospinal Fluid Barrier and The Blood-Brain Barrier without Sex Differences (2023)
- Differential Blood-Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro (2023)
- Understanding the Blood-Brain Barrier and Beyond (2022)
- Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood-brain barrier. (2021)
- Perspectives on Nanodelivery to the Brain (2020)
- Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls (2019)
- Targeted Brain Delivery of Methotrexate by Glutathione PEGylated Liposomes (2019)
- Understanding the Influence of Nanocarrier-Mediated Brain Delivery on Therapeutic Performance Through Pharmacokinetic-Pharmacodynamic Modeling (2019)
- Mechanistic Study on the Use of the L-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug (2019)
- A Cross-Sectional Study Assessing Appropriateness Of Inhaled Corticosteroid Treatment In Primary And Secondary Care Patients With COPD In Sweden (2019)
- Rate and extent of mitragynine and 7-hydroxymitragynine blood-brain barrier transport and their intra-brain distribution (2019)
- Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy (2018)
- Intact blood-brain barrier transport of small molecular drugs in animal models of amyloid beta and alpha-synuclein pathology (2018)
- In Vivo Quantitative Understanding of PEGylated Liposome’s Influence on Brain Delivery of Diphenhydramine (2018)
- Pharmacokinetics of Pericyte Involvement in Small-Molecular Drug Transport Across the Blood-Brain Barrier (2018)
- Rate of Small-Molecular Drug Transport Across the Blood-Brain Barrier in a Pericyte-Deficient State (2018)
- Recent advancements in liposomes targeting strategies to cross blood-brain barrier (BBB) for the treatment of Alzheimer's disease (2017)
- Influence of peptide transporter 2 (PEPT2) on the distribution of cefadroxil in mouse brain (2017)
- Revisiting atenolol as a low passive permeability marker (2017)
- Current research into brain barriers and the delivery of therapeutics for neurological diseases (2017)
- Combined PET and microdialysis for in vivo estimation of drug blood-brain barrier transport and brain unbound concentrations (2017)
- Microdialysis as an Important Technique in Systems Pharmacology (2017)
- The Impact of Liposomal Formulations on the Release and Brain Delivery of Methotrexate (2017)
- Professor Yuichi Sugiyama (2017)
- Quantitative Assessment of Drug Delivery to Tissues and Association with Phospholipidosis (2017)
- Lung Retention by Lysosomal Trapping of Inhaled Drugs Can Be Predicted In Vitro With Lung Slices (2016)
- Development of a Novel Lung Slice Methodology for Profiling of Inhaled Compounds (2016)
- Pharmacokinetic Considerations of Nanodelivery to the Brain (2016)
- Exploring Factors Causing Low Brain penetration of the Opioid Peptide DAMGO through Experimental Methods and Modeling (2016)
- In vivo Functional Evaluation of Increased Brain Delivery of the Opioid Peptide DAMGO by Glutathione-PEGylated Liposomes (2016)
- In-depth neuropharmacokinetic analysis of antipsychotics based on a novel approach to estimate unbound target-site concentration in CNS regions (2016)
- Improved method for quantitative analysis of the cyclotide kalata B1 in plasma and brain homogenate (2016)
- A tool for prediction of risk of rehospitalisation and mortality in the hospitalised elderly (2015)
- Translational Aspects of Blood-Brain Barrier Transport and Central Nervous System Effects of Drugs (2015)
- Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates (2015)
- Validation of a P-Glycoprotein (P-gp) Humanized Mouse Model by Integrating Selective Absolute Quantification of Human MDR1, Mouse Mdr1a and Mdr1b Protein Expressions with In Vivo Functional Analysis for Blood-Brain Barrier Transport (2015)
- The effects of pharmacist intervention on emergency department visits in patients 80 years and older (2014)
- Effect of transporter inhibitioin on the distribution of cefadroxil in rat brain (2014)
- Effect of transporter inhibition on the distribution of cefadroxil in rat brain (2014)
- Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery (2014)
- Prescription and transcription errors in multidose-dispensed medications on discharge from hospital (2013)
- Effects of Pharmacists' Interventions on Appropriateness of Prescribing and Evaluation of the Instruments' (MAI, STOPP and STARTs') Ability to Predict Hospitalization-Analyses from a Randomized Controlled Trial (2013)
- Perspectives on a pharmacokinetics legend (2013)
- Enhanced Brain Delivery of the Opioid Peptide DAMGO in Glutathione PEGylated Liposomes (2013)
- The brain slice method for studying drug distribution in the CNS (2013)
- Chain length of dietary alkylresorcinols affects their in vivo elimination kinetics in rats (2013)
- Oxymorphone active uptake at the blood-brain barrier and population modeling of its pharmacokinetic-pharmacodynamic relationship (2013)
- Perceived value of ward-based pharmacists from the perspective of physicians and nurses (2012)
- Quantitative analysis of the opioid peptide DAMGO in rat plasma and microdialysis samples using liquid chromatography-tandem mass spectrometry (2012)
- Mechanism-based PK-PD model for the prolactin biological system response following an acute dopamine inhibition challenge (2012)
- Measurement of Unbound Drug Exposure in Brain (2011)
- Diphenhydramine Active Uptake at the Blood-Brain Barrier and Its Interaction with Oxycodone in Vitro and in Vivo (2011)
- Morphine brain pharmacokinetics at very low concentrations studied with Accelerator Mass Spectrometry and Liquid Chromatography-tandem Mass Spectrometry (2011)
- Knowledge and insight in relation to functional remission in patients with long-term psychotic disorders (2010)
- Improved measurement of drug exposure in the brain using drug-specific correction for residual blood (2010)
- Active-Site Concentrations of Chemicals (2010)
- Using PET Studies of P-gp Function to Elucidate Mechanisms Underlying the Disposition of Drugs (2010)
- Treatmentresponse in psychotic patients classified according to social and clinical needs, drug side effects, and previous treatment; a method to identify functional remission (2009)
- Current and retrospective antipsychotic drug use in relation to treatment response in a naturalistic setting of psychotic patients (2009)
- The influence of age on the distribution of morphine and morphine-3-glucuronide across the blood-brain barrier in sheep (2009)
- Development of a High-Throughput Brain Slice Method for Studying Drug Distribution in the Central Nervous System (2009)
- Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids (2009)
- A comprehensive pharmacist intervention to reduce morbidity in patients 80 years or older (2009)
- Methodologies to assess brain drug delivery in lead optimization (2009)
- Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport (2009)
- Gene polymorphism influencing treatment response in psychotic patients in a naturalistic setting (2008)
- The use of a deuterated calibrator for in vivo recovery estimations in microdialysis studies (2008)
- Blood–Brain Barrier Transport Helps to Explain Discrepancies in In Vivo Potency between Oxycodone and Morphine (2008)
- On the rate and extent of drug delivery to the brain (2008)
- Involvement of the pyrilamine transporter, a putative organic cation transporter, in blood-brain barrier transport of oxycodone. (2008)
- Pharmacokinetics of P-glycoprotein inhibition in the rat blood-brain barrier (2008)
- AAPS-FDA workshop white paper (2007)
- AAPS-FDA workshop white paper (2007)
- AAPS-FDA Workshop White Paper (2007)
- In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids (2007)
- 5-hydroxy-L-[beta-C-11]tryptophan versus alpha-[C-11]methyl-L-tryptophan for positron emission tomography imaging of serotonin synthesis capacity in the rhesus monkey brain (2007)
- Effect on [11C]DASB binding after tranylcypromine-induced increase in serotonin concentration (2007)
- Morphine metabolism after major liver surgery (2007)
- In Vivo Blood-Brain Barrier Transport of Oxycodone in the Rat (2006)
- Differential response to estrogen challenge test in women with and without premenstrual dysphoria (2006)
- Predicting brain concentrations of drug using positron emission tomography and venous input (2006)
- Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET (2006)
- Pharmacokinetic consequences of active drug efflux at the blood-brain barrier (2006)
- On-line desalting and determination of morphine, morphine-3-glucuronide and morphine-6-glucuronide in microdialysis and plasma samples using column switching and liquid chromatography/tandem mass spectrometry (2005)
- Oxycodone Pharmacokinetics and Pharmacodynamics in the Rat in the Presence of the P-Glycoprotein Inhibitor PSC833 (2005)
- The Use of Liquid Chromatography/Mass Spectrometry for Quantitative Analysis of Oxycodone, Oxymorphone and Noroxycodone in Ringer Solution, Rat Plasma and Rat Brain Tissue (2004)
- Altered brain exposure of morphine in experimental meningitis studied with microdialysis (2004)
- An integrated model for the analysis of pharmacokinetic data from microdialysis experiments (2004)
- Modeling of transfer kinetics at the serum-cerebrospinal fluid barrier in rabbits with experimental meningitis (2003)
- Morphine blood-brain barrier transport is influenced by probenecid co-administration (2003)
- Blood-brain barrier transport and brain distribution of morphine-6-glucuronide in relation to the antinociceptive effect in rats (2001)
- Effects of pharmacists’ interventions on appropriateness of prescribing for elderly and exploration of a possible correlation between scores for appropriateness and clinical outcomes
- Dual behavior of cyclic peptides at the blood-brain barrier vs brain cellular uptake: Importance for CNS drug development
- Cellular uptake and intra-brain distribution of cyclic cell penetrating peptides: why tissue and cell type matters
- Species differences in blood-brain barrier transport of three PET radiotracers with emphasis on P-glycoprotein and plasma protein binding
Böcker
Kapitel
- Brain Distribution of Drugs: (2020)
- In Vivo Studies of Drug BBB Transport: (2020)
- In vivo approaches to assessing the blood-brain barrier (2014)
- Pharmacokinetic concepts in brain drug delivery (2014)
- Drug discovery methods for studying brain drug delivery and distribution (2014)
- Drug Discovery Methods for Studying Brain Drug Delivery and Distribution (2014)
- Microdialysis in CNS PKPD research: Unraveling unbound concentrations (2013)
- Microdialysis in CNS PKPD Research (2013)
