Margareta Hammarlund-Udenaes

Assessing central nervous system drug delivery

Hammarlund-Udenaes, Margareta; Loryan, Irena

Ingår i Expert Opinion on Drug Delivery, s. 421-439, 2025

• DOI för Assessing central nervous system drug delivery
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Does the drug enter the brain?: If so, how much?

Hammarlund-Udenaes, Margareta

Ingår i Journal of Pharmacology and Experimental Therapeutics, 2025

• DOI för Does the drug enter the brain?: If so, how much?

Reduced oxycodone brain delivery in rats due to lipopolysaccharide-induced inflammation: microdialysis insights into brain disposition and sex-specific pharmacokinetics

Bällgren, Frida; Hammarlund-Udenaes, Margareta; Loryan, Irena

Ingår i Fluids and Barriers of the CNS, 2024

• DOI för Reduced oxycodone brain delivery in rats due to lipopolysaccharide-induced inflammation: microdialysis insights into brain disposition and sex-specific pharmacokinetics
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Active CNS delivery of oxycodone in healthy and endotoxemic pigs

Bällgren, Frida; Bergfast, Tilda; Ginosyan, Aghavni; Mahajan, Jessica et al.

Ingår i Fluids and Barriers of the CNS, 2024

• DOI för Active CNS delivery of oxycodone in healthy and endotoxemic pigs
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Formulation-dependent differences in paclitaxel distribution to anatomical sites relevant to chemotherapy-induced peripheral neuropathy

Girdenytė, Milda; Hu, Yang; Ginosyan, Aghavni; Hammarlund-Udenaes, Margareta et al.

Ingår i Frontiers in Pharmacology, 2024

• DOI för Formulation-dependent differences in paclitaxel distribution to anatomical sites relevant to chemotherapy-induced peripheral neuropathy
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Does the drug enter the brain?: If so, how much?

Hammarlund-Udenaes, Margareta

Ingår i Journal of Pharmacology and Experimental Therapeutics, 2025

• DOI för Does the drug enter the brain?: If so, how much?

Reduced oxycodone brain delivery in rats due to lipopolysaccharide-induced inflammation: microdialysis insights into brain disposition and sex-specific pharmacokinetics

Bällgren, Frida; Hammarlund-Udenaes, Margareta; Loryan, Irena

Ingår i Fluids and Barriers of the CNS, 2024

• DOI för Reduced oxycodone brain delivery in rats due to lipopolysaccharide-induced inflammation: microdialysis insights into brain disposition and sex-specific pharmacokinetics
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Active CNS delivery of oxycodone in healthy and endotoxemic pigs

Bällgren, Frida; Bergfast, Tilda; Ginosyan, Aghavni; Mahajan, Jessica et al.

Ingår i Fluids and Barriers of the CNS, 2024

• DOI för Active CNS delivery of oxycodone in healthy and endotoxemic pigs
• Ladda ner fulltext (pdf) av Active CNS delivery of oxycodone in healthy and endotoxemic pigs

Formulation-dependent differences in paclitaxel distribution to anatomical sites relevant to chemotherapy-induced peripheral neuropathy

Girdenytė, Milda; Hu, Yang; Ginosyan, Aghavni; Hammarlund-Udenaes, Margareta et al.

Ingår i Frontiers in Pharmacology, 2024

• DOI för Formulation-dependent differences in paclitaxel distribution to anatomical sites relevant to chemotherapy-induced peripheral neuropathy
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Region-independent active CNS net uptake of marketed H⁺/ OC antiporter system substrates

Bällgren, Frida; Hu, Yang; Li, Shannuo; van de Beek, Lara et al.

Ingår i Frontiers in Cellular Neuroscience, 2024

• DOI för Region-independent active CNS net uptake of marketed H⁺/ OC antiporter system substrates
• Ladda ner fulltext (pdf) av Region-independent active CNS net uptake of marketed H⁺/ OC antiporter system substrates

Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy

Hu, Yang; Girdenyte, Milda; Roest, Lieke; Liukkonen, Iida et al.

Ingår i Fluids and Barriers of the CNS, 2024

• DOI för Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy
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Differential Blood-Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro

Melander, Erik; Eriksson, Camilla; Wellens, Sara; Hosseini, Kimia et al.

Ingår i Pharmaceutics, 2023

• DOI för Differential Blood-Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro
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Active Uptake of Oxycodone at Both the Blood-Cerebrospinal Fluid Barrier and The Blood-Brain Barrier without Sex Differences: A Rat Microdialysis Study

Bällgren, Frida; Hammarlund-Udenaes, Margareta; Loryan, Irena

Ingår i Pharmaceutical research, s. 2715-2730, 2023

• DOI för Active Uptake of Oxycodone at Both the Blood-Cerebrospinal Fluid Barrier and The Blood-Brain Barrier without Sex Differences: A Rat Microdialysis Study
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Understanding the Blood-Brain Barrier and Beyond: Challenges and Opportunities for Novel CNS Therapeutics

de Lange, Elizabeth C. M.; Hammarlund-Udenaes, Margareta

Ingår i Clinical Pharmacology and Therapeutics, s. 758-773, 2022

• DOI för Understanding the Blood-Brain Barrier and Beyond: Challenges and Opportunities for Novel CNS Therapeutics
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Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood-brain barrier.

Luptáková, Dominika; Vallianatou, Theodosia; Nilsson, Anna; Shariatgorji, Reza et al.

Ingår i Molecular Psychiatry, s. 7732-7745, 2021

• DOI för Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood-brain barrier.
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Perspectives on Nanodelivery to the Brain: Prerequisites for Successful Brain Treatment

Hu, Yang; Hammarlund-Udenaes, Margareta

Ingår i Molecular Pharmaceutics, s. 4029-4039, 2020

• DOI för Perspectives on Nanodelivery to the Brain: Prerequisites for Successful Brain Treatment
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Understanding the Influence of Nanocarrier-Mediated Brain Delivery on Therapeutic Performance Through Pharmacokinetic-Pharmacodynamic Modeling

Hu, Yang; Hammarlund-Udenaes, Margareta; Fridén, Markus

Ingår i Journal of Pharmaceutical Sciences, s. 3425-3433, 2019

• DOI för Understanding the Influence of Nanocarrier-Mediated Brain Delivery on Therapeutic Performance Through Pharmacokinetic-Pharmacodynamic Modeling

Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development

Gustafsson, Sofia; Sehlin, Dag; Lampa, Erik; Hammarlund-Udenaes, Margareta et al.

Ingår i Scientific Reports, 2019

• DOI för Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development
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A Cross-Sectional Study Assessing Appropriateness Of Inhaled Corticosteroid Treatment In Primary And Secondary Care Patients With COPD In Sweden

Sulku, Johanna; Jansson, Christer; Melhus, Håkan; Malinovschi, Andrei et al.

Ingår i The International Journal of Chronic Obstructive Pulmonary Disease, s. 2451-2460, 2019

• DOI för A Cross-Sectional Study Assessing Appropriateness Of Inhaled Corticosteroid Treatment In Primary And Secondary Care Patients With COPD In Sweden
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Rate and extent of mitragynine and 7-hydroxymitragynine blood-brain barrier transport and their intra-brain distribution: the missing link in pharmacodynamic studies

Yusof, Siti R; Mohd Uzid, Mahathir; Teh, Eng-Huat; Hanapi, Nur Aziah et al.

Ingår i Addiction Biology, s. 935-945, 2019

• DOI för Rate and extent of mitragynine and 7-hydroxymitragynine blood-brain barrier transport and their intra-brain distribution: the missing link in pharmacodynamic studies

Mechanistic Study on the Use of the L-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets

Puris, Elena; Gynther, Mikko; de Lange, Elizabeth C. M.; Auriola, Seppo et al.

Ingår i Molecular Pharmaceutics, s. 3261-3274, 2019

• DOI för Mechanistic Study on the Use of the L-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets

Targeted Brain Delivery of Methotrexate by Glutathione PEGylated Liposomes: How can the Formulation Make a Difference?

Hu, Yang; Gaillard, Pieter J.; De lange, Elizabeth C.M.; Hammarlund-Udenaes, Margareta

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 197-204, 2019

• DOI för Targeted Brain Delivery of Methotrexate by Glutathione PEGylated Liposomes: How can the Formulation Make a Difference?

Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy

Gustafsson, Sofia; Gustavsson, Tobias; Roshanbin, Sahar; Hultqvist, Greta et al.

Ingår i Neuropharmacology, s. 1-9, 2018

• DOI för Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy
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Intact blood-brain barrier transport of small molecular drugs in animal models of amyloid beta and alpha-synuclein pathology

Gustafsson, Sofia; Lindström, Veronica; Ingelsson, Martin; Hammarlund-Udenaes, Margareta et al.

Ingår i Neuropharmacology, s. 482-491, 2018

• DOI för Intact blood-brain barrier transport of small molecular drugs in animal models of amyloid beta and alpha-synuclein pathology
• Ladda ner fulltext (pdf) av Intact blood-brain barrier transport of small molecular drugs in animal models of amyloid beta and alpha-synuclein pathology

In Vivo Quantitative Understanding of PEGylated Liposome’s Influence on Brain Delivery of Diphenhydramine

Hu, Yang; Gaillard, Pieter J.; Rip, Jaap; De lange, Elizabeth C.M. et al.

Ingår i Molecular Pharmaceutics, s. 5493-5500, 2018

• DOI för In Vivo Quantitative Understanding of PEGylated Liposome’s Influence on Brain Delivery of Diphenhydramine

Rate of Small-Molecular Drug Transport Across the Blood-Brain Barrier in a Pericyte-Deficient State

Mihajlica, Nebojsa; Betsholtz, Christer; Hammarlund-Udenaes, Margareta

Ingår i European Journal of Pharmaceutical Sciences, s. 182-187, 2018

• DOI för Rate of Small-Molecular Drug Transport Across the Blood-Brain Barrier in a Pericyte-Deficient State

Pharmacokinetics of Pericyte Involvement in Small-Molecular Drug Transport Across the Blood-Brain Barrier

Mihajlica, Nebojsa; Betsholtz, Christer; Hammarlund-Udenaes, Margareta

Ingår i European Journal of Pharmaceutical Sciences, s. 77-84, 2018

• DOI för Pharmacokinetics of Pericyte Involvement in Small-Molecular Drug Transport Across the Blood-Brain Barrier

Revisiting atenolol as a low passive permeability marker

Chen, Xiaomei; Slättengren, Tim; de Lange, Elizabeth C. M.; Smith, David E. et al.

Ingår i Fluids and Barriers of the CNS, 2017

• DOI för Revisiting atenolol as a low passive permeability marker
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The Impact of Liposomal Formulations on the Release and Brain Delivery of Methotrexate: An In Vivo Microdialysis Study

Hu, Yang; Rip, Jaap; Gaillard, Pieter J.; de lange, Elizabeth C. M. et al.

Ingår i Journal of Pharmaceutical Sciences, s. 2606-2613, 2017

• DOI för The Impact of Liposomal Formulations on the Release and Brain Delivery of Methotrexate: An In Vivo Microdialysis Study

Combined PET and microdialysis for in vivo estimation of drug blood-brain barrier transport and brain unbound concentrations

Gustafsson, Sofia; Eriksson, Jonas; Syvänen, Stina; Eriksson, Olof et al.

Ingår i NeuroImage, s. 177-186, 2017

• DOI för Combined PET and microdialysis for in vivo estimation of drug blood-brain barrier transport and brain unbound concentrations

Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist

Kusuhara, Hiroyuki; Obach, R. Scott; Rostami-Hodjegan, Amin; Pang, K. Sandy et al.

Ingår i Journal of Pharmaceutical Sciences, s. 2188-2194, 2017

• DOI för Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist

Quantitative Assessment of Drug Delivery to Tissues and Association with Phospholipidosis: A Case Study with Two Structurally Related Diamines in Development

Loryan, Irena; Hoppe, Edmund; Hansen, Klaus; Held, Felix et al.

Ingår i Molecular Pharmaceutics, s. 4362-4373, 2017

• DOI för Quantitative Assessment of Drug Delivery to Tissues and Association with Phospholipidosis: A Case Study with Two Structurally Related Diamines in Development

Influence of peptide transporter 2 (PEPT2) on the distribution of cefadroxil in mouse brain: A microdialysis study

Chen, Xiaomei; Keep, Richard F.; Liang, Yan; Zhu, Hao-Jie et al.

Ingår i Biochemical Pharmacology, s. 89-97, 2017

• DOI för Influence of peptide transporter 2 (PEPT2) on the distribution of cefadroxil in mouse brain: A microdialysis study

Pharmacokinetic Considerations of Nanodelivery to the Brain: Using Modeling and Simulations to Predict Outcome of Liposomal Formulations

Lindqvist, Annika; Fridén, Markus; Hammarlund-Udenaes, Margareta

Ingår i European Journal of Pharmaceutical Sciences, s. 173-182, 2016

• DOI för Pharmacokinetic Considerations of Nanodelivery to the Brain: Using Modeling and Simulations to Predict Outcome of Liposomal Formulations

In vivo Functional Evaluation of Increased Brain Delivery of the Opioid Peptide DAMGO by Glutathione-PEGylated Liposomes

Lindqvist, Annika; Rip, Jaap; van Kregten, Joan; Gaillard, Pieter J et al.

Ingår i Pharmaceutical research, s. 177-185, 2016

• DOI för In vivo Functional Evaluation of Increased Brain Delivery of the Opioid Peptide DAMGO by Glutathione-PEGylated Liposomes

Exploring Factors Causing Low Brain penetration of the Opioid Peptide DAMGO through Experimental Methods and Modeling

Lindqvist, Annika; Jönsson, Siv; Hammarlund-Udenaes, Margareta

Ingår i Molecular Pharmaceutics, s. 1258-1266, 2016

• DOI för Exploring Factors Causing Low Brain penetration of the Opioid Peptide DAMGO through Experimental Methods and Modeling

In-depth neuropharmacokinetic analysis of antipsychotics based on a novel approach to estimate unbound target-site concentration in CNS regions: link to spatial receptor occupancy

Loryan, Irena; Melander, Erik; Svensson, M.; Payan, M. et al.

Ingår i Molecular Psychiatry, s. 1527-1536, 2016

• DOI för In-depth neuropharmacokinetic analysis of antipsychotics based on a novel approach to estimate unbound target-site concentration in CNS regions: link to spatial receptor occupancy

Improved method for quantitative analysis of the cyclotide kalata B1 in plasma and brain homogenate

Melander, Erik; Eriksson, Camilla; Jansson, Britt; Göransson, Ulf et al.

Ingår i Biopolymers, s. 910-916, 2016

• DOI för Improved method for quantitative analysis of the cyclotide kalata B1 in plasma and brain homogenate
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Lung Retention by Lysosomal Trapping of Inhaled Drugs Can Be Predicted In Vitro With Lung Slices

Bäckström, Erica; Boger, Elin; Lundqvist, Anders; Hammarlund-Udenaes, Margareta et al.

Ingår i Journal of Pharmaceutical Sciences, s. 3432-3439, 2016

• DOI för Lung Retention by Lysosomal Trapping of Inhaled Drugs Can Be Predicted In Vitro With Lung Slices

Development of a Novel Lung Slice Methodology for Profiling of Inhaled Compounds

Bäckström, Erica; Lundqvist, Anders; Boger, Elin; Svanberg, Petter et al.

Ingår i Journal of Pharmaceutical Sciences, s. 838-845, 2016

• DOI för Development of a Novel Lung Slice Methodology for Profiling of Inhaled Compounds

A tool for prediction of risk of rehospitalisation and mortality in the hospitalised elderly: secondary analysis of clinical trial data

Alassaad, Anna; Melhus, Håkan; Hammarlund-Udenaes, Margareta; Bertilsson, Maria et al.

Ingår i BMJ Open, 2015

• DOI för A tool for prediction of risk of rehospitalisation and mortality in the hospitalised elderly: secondary analysis of clinical trial data
• Ladda ner fulltext (pdf) av A tool for prediction of risk of rehospitalisation and mortality in the hospitalised elderly: secondary analysis of clinical trial data

Validation of a P-Glycoprotein (P-gp) Humanized Mouse Model by Integrating Selective Absolute Quantification of Human MDR1, Mouse Mdr1a and Mdr1b Protein Expressions with In Vivo Functional Analysis for Blood-Brain Barrier Transport

Sadiq, Muhammad Waqas; Uchida, Yasuo; Hoshi, Yutaro; Tachikawa, Masanori et al.

Ingår i PLOS ONE, 2015

• DOI för Validation of a P-Glycoprotein (P-gp) Humanized Mouse Model by Integrating Selective Absolute Quantification of Human MDR1, Mouse Mdr1a and Mdr1b Protein Expressions with In Vivo Functional Analysis for Blood-Brain Barrier Transport
• Ladda ner fulltext (pdf) av Validation of a P-Glycoprotein (P-gp) Humanized Mouse Model by Integrating Selective Absolute Quantification of Human MDR1, Mouse Mdr1a and Mdr1b Protein Expressions with In Vivo Functional Analysis for Blood-Brain Barrier Transport

Translational Aspects of Blood-Brain Barrier Transport and Central Nervous System Effects of Drugs: From Discovery to Patients

de Lange, E. C. M.; Hammarlund-Udenaes, Margareta

Ingår i Clinical Pharmacology and Therapeutics, s. 380-394, 2015

• DOI för Translational Aspects of Blood-Brain Barrier Transport and Central Nervous System Effects of Drugs: From Discovery to Patients

Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates

Loryan, Irena; Sinha, Vikash; Mackie, Claire; van Peer, Achiel et al.

Ingår i Molecular Pharmaceutics, s. 520-532, 2015

• DOI för Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates

Effect of transporter inhibitioin on the distribution of cefadroxil in rat brain

Chen, Xiaomei; Loryan, Irena; Payan, Maryam; Keep, Richard F. et al.

Ingår i Fluids and Barriers of the CNS, 2014

• DOI för Effect of transporter inhibitioin on the distribution of cefadroxil in rat brain
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Effect of transporter inhibition on the distribution of cefadroxil in rat brain

Chen, Xiaomei; Loryan, Irena; Payan, Maryam; Keep, Richard et al.

Ingår i Fluids and Barriers of the CNS, 2014

• DOI för Effect of transporter inhibition on the distribution of cefadroxil in rat brain
• Ladda ner fulltext (pdf) av Effect of transporter inhibition on the distribution of cefadroxil in rat brain

The effects of pharmacist intervention on emergency department visits in patients 80 years and older: subgroup analyses by number of prescribed drugs and appropriate prescribing

Alassaad, Anna; Bertilsson, Maria; Gillespie, Ulrika; Sundström, Johan et al.

Ingår i PLOS ONE, 2014

• DOI för The effects of pharmacist intervention on emergency department visits in patients 80 years and older: subgroup analyses by number of prescribed drugs and appropriate prescribing
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Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery

Loryan, Irena; Vikash, Sinha; Claire, Mackie; Van Peer, Achiel et al.

Ingår i Pharmaceutical research, s. 2203-2219, 2014

• DOI för Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery

The brain slice method for studying drug distribution in the CNS

Loryan, Irena; Friden, Markus; Hammarlund-Udenaes, Margareta

Ingår i Fluids and Barriers of the CNS, s. 6, 2013

• DOI för The brain slice method for studying drug distribution in the CNS
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Enhanced Brain Delivery of the Opioid Peptide DAMGO in Glutathione PEGylated Liposomes: A Microdialysis Study

Lindqvist, Annika; Rip, Jaap; Gaillard, Pieter J; Björkman, Sven et al.

Ingår i Molecular Pharmaceutics, s. 1533-1541, 2013

• DOI för Enhanced Brain Delivery of the Opioid Peptide DAMGO in Glutathione PEGylated Liposomes: A Microdialysis Study

Effects of Pharmacists' Interventions on Appropriateness of Prescribing and Evaluation of the Instruments' (MAI, STOPP and STARTs') Ability to Predict Hospitalization-Analyses from a Randomized Controlled Trial

Gillespie, Ulrika; Alassaad, Anna; Hammarlund-Udenaes, Margareta; Morlin, Claes et al.

Ingår i PLOS ONE, 2013

• DOI för Effects of Pharmacists' Interventions on Appropriateness of Prescribing and Evaluation of the Instruments' (MAI, STOPP and STARTs') Ability to Predict Hospitalization-Analyses from a Randomized Controlled Trial
• Ladda ner fulltext (pdf) av Effects of Pharmacists' Interventions on Appropriateness of Prescribing and Evaluation of the Instruments' (MAI, STOPP and STARTs') Ability to Predict Hospitalization-Analyses from a Randomized Controlled Trial

Oxymorphone active uptake at the blood-brain barrier and population modeling of its pharmacokinetic-pharmacodynamic relationship

Sadiq, Muhammad Waqas; Boström, Emma; Keizer, Ron; Björkman, Sven et al.

Ingår i Journal of Pharmaceutical Sciences, s. 3320-3331, 2013

• DOI för Oxymorphone active uptake at the blood-brain barrier and population modeling of its pharmacokinetic-pharmacodynamic relationship

Prescription and transcription errors in multidose-dispensed medications on discharge from hospital: an observationaland interventional study

Alassaad, Anna; Gillespie, Ulrika; Bertilsson, Maria; Melhus, Håkan et al.

Ingår i Journal of Evaluation In Clinical Practice, s. 185-191, 2013

• DOI för Prescription and transcription errors in multidose-dispensed medications on discharge from hospital: an observationaland interventional study

Perspectives on a pharmacokinetics legend: C versus T (contributions over time)

Hammarlund-Udenaes, Margareta; Brouwer, Kim; Nakashima, Emi; Terasaki, Tetsuya

Ingår i Journal of Pharmaceutical Sciences, s. 2889-2894, 2013

• DOI för Perspectives on a pharmacokinetics legend: C versus T (contributions over time)

Chain length of dietary alkylresorcinols affects their in vivo elimination kinetics in rats

Marklund, Matti; Strömberg, Eric A; Hooker, Andrew C; Hammarlund-Udenaes, Margareta et al.

Ingår i Journal of Nutrition, s. 1573-1578, 2013

• DOI för Chain length of dietary alkylresorcinols affects their in vivo elimination kinetics in rats

Quantitative analysis of the opioid peptide DAMGO in rat plasma and microdialysis samples using liquid chromatography-tandem mass spectrometry

Lindqvist, Annika; Jansson, Britt; Hammarlund-Udenaes, Margareta

Ingår i Journal of chromatography. B, s. 11-17, 2012

• DOI för Quantitative analysis of the opioid peptide DAMGO in rat plasma and microdialysis samples using liquid chromatography-tandem mass spectrometry

Mechanism-based PK-PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans

Stevens, Jasper; Ploeger, Bart A.; Hammarlund-Udenaes, Margareta; Osswald, Gunilla et al.

Ingår i Journal of Pharmacokinetics and Pharmacodynamics, s. 463-477, 2012

• DOI för Mechanism-based PK-PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans

Perceived value of ward-based pharmacists from the perspective of physicians and nurses

Gillespie, Ulrika; Mörlin, Claes; Hammarlund-Udenaes, Margareta; Hedström, Mariann

Ingår i International Journal of Clinical Pharmacy, s. 127-135, 2012

• DOI för Perceived value of ward-based pharmacists from the perspective of physicians and nurses

Measurement of Unbound Drug Exposure in Brain: Modelling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods

Fridén, Markus; Bergström, Fredrik; Wan, Hong; Rehngren, Mikael et al.

Ingår i Drug Metabolism And Disposition, s. 353-362, 2011

• DOI för Measurement of Unbound Drug Exposure in Brain: Modelling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods

Morphine brain pharmacokinetics at very low concentrations studied with Accelerator Mass Spectrometry and Liquid Chromatography-tandem Mass Spectrometry

Sadiq, Muhammad Waqas; Salehpour, Mehran; Forsgård, Niklas; Possnert, Göran et al.

Ingår i Drug Metabolism And Disposition, s. 174-179, 2011

• DOI för Morphine brain pharmacokinetics at very low concentrations studied with Accelerator Mass Spectrometry and Liquid Chromatography-tandem Mass Spectrometry

Diphenhydramine Active Uptake at the Blood-Brain Barrier and Its Interaction with Oxycodone in Vitro and in Vivo

Sadiq, Muhammad Waqas; Borgs, Annika; Okura, Takashi; Shimomura, Keita et al.

Ingår i Journal of Pharmaceutical Sciences, s. 3912-3923, 2011

• DOI för Diphenhydramine Active Uptake at the Blood-Brain Barrier and Its Interaction with Oxycodone in Vitro and in Vivo

Improved measurement of drug exposure in the brain using drug-specific correction for residual blood

Fridén, Markus; Ljungqvist, Helena; Middleton, Brian; Bredberg, Ulf et al.

Ingår i Journal of Cerebral Blood Flow and Metabolism, s. 150-161, 2010

• DOI för Improved measurement of drug exposure in the brain using drug-specific correction for residual blood

Knowledge and insight in relation to functional remission in patients with long-term psychotic disorders

Alenius, Malin; Hammarlund-Udenaes, Margareta; Hartvig, Per; Lindström, Leif

Ingår i Social Psychiatry and Psychiatric Epidemiology, s. 523-529, 2010

• DOI för Knowledge and insight in relation to functional remission in patients with long-term psychotic disorders

Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids

Fridén, Markus; Winiwarter, Susanne; Jerndal, Gunilla; Bengtsson, Ola et al.

Ingår i Journal of Medicinal Chemistry, s. 6233-6243, 2009

• DOI för Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids

A comprehensive pharmacist intervention to reduce morbidity in patients 80 years or older: a randomized controlled trial

Gillespie, Ulrika; Alassaad, Anna; Henrohn, Dan; Garmo, Hans et al.

Ingår i Archives of Internal Medicine, s. 894-900, 2009

• DOI för A comprehensive pharmacist intervention to reduce morbidity in patients 80 years or older: a randomized controlled trial

Development of a High-Throughput Brain Slice Method for Studying Drug Distribution in the Central Nervous System

Fridén, Markus; Ducrozet, Frederic; Middleton, Brian; Antonsson, Madeleine et al.

Ingår i Drug Metabolism And Disposition, s. 1226-1233, 2009

• DOI för Development of a High-Throughput Brain Slice Method for Studying Drug Distribution in the Central Nervous System

Treatmentresponse in psychotic patients classified according to social and clinical needs, drug side effects, and previous treatment; a method to identify functional remission

Alenius, Malin; Hammarlund-Udenaes, Margareta; Hartvig, Per; Sundquist, Staffan et al.

Ingår i Comprehensive Psychiatry, s. 453-462, 2009

• DOI för Treatmentresponse in psychotic patients classified according to social and clinical needs, drug side effects, and previous treatment; a method to identify functional remission

The influence of age on the distribution of morphine and morphine-3-glucuronide across the blood-brain barrier in sheep

Bengtsson, Jörgen; Ederoth, P; Ley, D; Hansson, S et al.

Ingår i British Journal of Pharmacology, s. 1085-1096, 2009

• DOI för The influence of age on the distribution of morphine and morphine-3-glucuronide across the blood-brain barrier in sheep

Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport

Syvänen, Stina; Lindhe, Örjan; Palner, Mikael; Kornum, Birgitte R et al.

Ingår i Drug Metabolism And Disposition, s. 635-643, 2009

• DOI för Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport

Gene polymorphism influencing treatment response in psychotic patients in a naturalistic setting

Alenius, Malin; Wadelius, Mia; Dahl, Marja-Liisa; Hartvig, Per et al.

Ingår i Journal of Psychiatric Research, s. 884-893, 2008

• DOI för Gene polymorphism influencing treatment response in psychotic patients in a naturalistic setting

Blood–Brain Barrier Transport Helps to Explain Discrepancies in In Vivo Potency between Oxycodone and Morphine

Boström, Emma; Hammarlund-Udenaes, Margareta; Simonsson, Ulrika S. H.

Ingår i Anesthesiology, s. 495-505, 2008

• DOI för Blood–Brain Barrier Transport Helps to Explain Discrepancies in In Vivo Potency between Oxycodone and Morphine

The use of a deuterated calibrator for in vivo recovery estimations in microdialysis studies

Bengtsson, Jörgen; Boström, Emma; Hammarlund-Udenaes, Margareta

Ingår i Journal of Pharmaceutical Sciences, s. 3433-3441, 2008

• DOI för The use of a deuterated calibrator for in vivo recovery estimations in microdialysis studies

Pharmacokinetics of P-glycoprotein inhibition in the rat blood-brain barrier

Syvänen, Stina; Hooker, Andrew; Rahman, Obaidur; Wilking, Helena et al.

Ingår i Journal of Pharmaceutical Sciences, s. 5386-5400, 2008

• DOI för Pharmacokinetics of P-glycoprotein inhibition in the rat blood-brain barrier

AAPS-FDA workshop white paper: Microdialysis principles, application, and regulatory perspectives report from the joint AAPS-FDA workshop, November 4-5, 2005, Nashville, TN

Chaurasia, Chandra S.; Mueller, Markus; Bashaw, Edward D.; Benfeldt, Eva et al.

Ingår i AAPS Journal, 2007

• DOI för AAPS-FDA workshop white paper: Microdialysis principles, application, and regulatory perspectives report from the joint AAPS-FDA workshop, November 4-5, 2005, Nashville, TN

Morphine metabolism after major liver surgery

Rudin, Åsa; Lundberg, Johan F.; Hammarlund-Udenaes, Margareta; Flisberg, Per et al.

Ingår i Anesthesia and Analgesia, s. 1409-1414, 2007

• DOI för Morphine metabolism after major liver surgery

AAPS-FDA Workshop White Paper: microdialysis principles, application, and regulatory perspectives

Chaurasia, Chandra S.; Müller, Markus; Bashaw, Edward D.; Benfeldt, Eva et al.

Ingår i Journal of clinical pharmacology, s. 589-603, 2007

• DOI för AAPS-FDA Workshop White Paper: microdialysis principles, application, and regulatory perspectives

AAPS-FDA workshop white paper: microdialysis principles, application and regulatory perspectives

Chaurasia, Chandra S.; Müller, Markus; Bashaw, Edward D.; Benfeldt, Eva et al.

Ingår i Pharmaceutical research, s. 1014-1025, 2007

• DOI för AAPS-FDA workshop white paper: microdialysis principles, application and regulatory perspectives

In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids

Fridén, Markus; Gupta, Anubha; Antonsson, Madeleine; Bredberg, Ulf et al.

Ingår i Drug Metabolism And Disposition, s. 1711-1719, 2007

• DOI för In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids

Effect on [11C]DASB binding after tranylcypromine-induced increase in serotonin concentration: positron emission tomography studies in monkeys and rats

Lundquist, Pinelopi; Roman, Magnus; Syvänen, Stina; Hartvig, Per et al.

Ingår i Synapse, s. 440-449, 2007

• DOI för Effect on [11C]DASB binding after tranylcypromine-induced increase in serotonin concentration: positron emission tomography studies in monkeys and rats

5-hydroxy-L-[beta-C-11]tryptophan versus alpha-[C-11]methyl-L-tryptophan for positron emission tomography imaging of serotonin synthesis capacity in the rhesus monkey brain

Lundquist, Pinelopi; Hartvig, Per; Blomquist, Gunnar; Hammarlund-Udenaes, Margareta et al.

Ingår i Journal of Cerebral Blood Flow and Metabolism, s. 821-830, 2007

• DOI för 5-hydroxy-L-[beta-C-11]tryptophan versus alpha-[C-11]methyl-L-tryptophan for positron emission tomography imaging of serotonin synthesis capacity in the rhesus monkey brain

Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET

Syvänen, Stina; Blomquist, Gunnar; Sprycha, Margareta; Höglund, A. Urban et al.

Ingår i NeuroImage, s. 1134-1141, 2006

• DOI för Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET

In Vivo Blood-Brain Barrier Transport of Oxycodone in the Rat: Indications for Active Influx and Implications for Pharmacokinetics/Pharmacodynamics

Boström, Emma; Simonsson, Ulrika S. H.; Hammarlund-Udenaes, Margareta

Ingår i Drug Metabolism And Disposition, s. 1624-1631, 2006

• DOI för In Vivo Blood-Brain Barrier Transport of Oxycodone in the Rat: Indications for Active Influx and Implications for Pharmacokinetics/Pharmacodynamics

Pharmacokinetic consequences of active drug efflux at the blood-brain barrier

Syvänen, Stina; Xie, Ruija; Sahin, Selma; Hammarlund-Udenaes, Margareta

Ingår i Pharmaceutical research, s. 705-717, 2006

• DOI för Pharmacokinetic consequences of active drug efflux at the blood-brain barrier

Predicting brain concentrations of drug using positron emission tomography and venous input: modeling of arterial-venous concentration differences

Syvänen, Stina; Blomquist, Gunnar; Appel, Lieuwe; Hammarlund-Udenaes, Margareta et al.

Ingår i European Journal of Clinical Pharmacology, s. 839-848, 2006

• DOI för Predicting brain concentrations of drug using positron emission tomography and venous input: modeling of arterial-venous concentration differences

Differential response to estrogen challenge test in women with and without premenstrual dysphoria

Eriksson, Olle; Bäckström, Torbjörn; Stridsberg, Mats; Hammarlund-Udenaes, Margareta et al.

Ingår i Psychoneuroendocrinology, s. 415-427, 2006

• DOI för Differential response to estrogen challenge test in women with and without premenstrual dysphoria

Oxycodone Pharmacokinetics and Pharmacodynamics in the Rat in the Presence of the P-Glycoprotein Inhibitor PSC833

Boström, Emma; Simonsson, Ulrika S. H.; Hammarlund-Udenaes, Margareta

Ingår i Journal of Pharmaceutical Sciences, s. 1060-1066, 2005

• DOI för Oxycodone Pharmacokinetics and Pharmacodynamics in the Rat in the Presence of the P-Glycoprotein Inhibitor PSC833

On-line desalting and determination of morphine, morphine-3-glucuronide and morphine-6-glucuronide in microdialysis and plasma samples using column switching and liquid chromatography/tandem mass spectrometry

Bengtsson, Jörgen; Jansson, Britt; Hammarlund-Udenaes, Margareta

Ingår i Rapid Communications in Mass Spectrometry, s. 2116-2122, 2005

• DOI för On-line desalting and determination of morphine, morphine-3-glucuronide and morphine-6-glucuronide in microdialysis and plasma samples using column switching and liquid chromatography/tandem mass spectrometry

The Use of Liquid Chromatography/Mass Spectrometry for Quantitative Analysis of Oxycodone, Oxymorphone and Noroxycodone in Ringer Solution, Rat Plasma and Rat Brain Tissue

Boström, Emma; Jansson, Britt; Hammarlund-Udenaes, Margareta; Simonsson, Ulrika S. H.

Ingår i Rapid Communications in Mass Spectrometry, s. 2565-2576, 2004

• DOI för The Use of Liquid Chromatography/Mass Spectrometry for Quantitative Analysis of Oxycodone, Oxymorphone and Noroxycodone in Ringer Solution, Rat Plasma and Rat Brain Tissue

An integrated model for the analysis of pharmacokinetic data from microdialysis experiments

Tunblad, Karin; Hammarlund-Udenaes, Margareta; Jonsson, Niclas E.

Ingår i Pharmaceutical research, s. 1698-1707, 2004

• DOI för An integrated model for the analysis of pharmacokinetic data from microdialysis experiments

Altered brain exposure of morphine in experimental meningitis studied with microdialysis

Tunblad, Karin; Ederoth, Per; Gärdenfors, Anna; Hammarlund-Udenaes, Margareta et al.

Ingår i Acta Anaesthesiologica Scandinavica, s. 294-301, 2004

• DOI för Altered brain exposure of morphine in experimental meningitis studied with microdialysis

Morphine blood-brain barrier transport is influenced by probenecid co-administration

Tunblad, Karin; Jonsson, E Niclas; Hammarlund-Udenaes, Margareta

Ingår i Pharmaceutical research, s. 618-623, 2003

• DOI för Morphine blood-brain barrier transport is influenced by probenecid co-administration

Modeling of transfer kinetics at the serum-cerebrospinal fluid barrier in rabbits with experimental meningitis: application to grepafloxacin.

Pfister, Marc; Zhang, Liping; Hammarlund-Udenaes, Margareta; Sheiner, Lewis B et al.

Ingår i Antimicrob Agents Chemother, s. 138-43, 2003

Blood-brain barrier transport and brain distribution of morphine-6-glucuronide in relation to the antinociceptive effect in rats: pharmacokinetic/pharmacodynamic modelling

Bouw, M. René; Xie, Rujia; Tunblad, Karin; Hammarlund-Udenaes, Margareta

Ingår i British Journal of Pharmacology, s. 1796-1804, 2001

• DOI för Blood-brain barrier transport and brain distribution of morphine-6-glucuronide in relation to the antinociceptive effect in rats: pharmacokinetic/pharmacodynamic modelling

Assessing central nervous system drug delivery

Hammarlund-Udenaes, Margareta; Loryan, Irena

Ingår i Expert Opinion on Drug Delivery, s. 421-439, 2025

• DOI för Assessing central nervous system drug delivery
• Ladda ner fulltext (pdf) av Assessing central nervous system drug delivery

Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017

Greenwood, John; Hammarlund-Udenaes, Margareta; Jones, Hazel C.; Stitt, Alan W. et al.

Ingår i Fluids and Barriers of the CNS, 2017

• DOI för Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017
• Ladda ner fulltext (pdf) av Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017

Microdialysis as an Important Technique in Systems Pharmacology: a Historical and Methodological Review

Hammarlund-Udenaes, Margareta

Ingår i AAPS Journal, s. 1294-1303, 2017

• DOI för Microdialysis as an Important Technique in Systems Pharmacology: a Historical and Methodological Review
• Ladda ner fulltext (pdf) av Microdialysis as an Important Technique in Systems Pharmacology: a Historical and Methodological Review

Recent advancements in liposomes targeting strategies to cross blood-brain barrier (BBB) for the treatment of Alzheimer's disease

Agrawal, Mukta; Ajazuddin, A; Tripathi, Dulal K.; Saraf, Swarnlata et al.

Ingår i Journal of Controlled Release, s. 61-77, 2017

• DOI för Recent advancements in liposomes targeting strategies to cross blood-brain barrier (BBB) for the treatment of Alzheimer's disease

Active-Site Concentrations of Chemicals: Are They a Better Predictor of Effect than Plasma/Organ/Tissue Concentrations?

Hammarlund-Udenaes, Margareta

Ingår i Basic & Clinical Pharmacology & Toxicology, s. 215-220, 2010

• DOI för Active-Site Concentrations of Chemicals: Are They a Better Predictor of Effect than Plasma/Organ/Tissue Concentrations?

Using PET Studies of P-gp Function to Elucidate Mechanisms Underlying the Disposition of Drugs

Syvänen, Stina; Hammarlund-Udenaes, Margareta

Ingår i Current Topics in Medicinal Chemistry, s. 1799-1809, 2010

• DOI för Using PET Studies of P-gp Function to Elucidate Mechanisms Underlying the Disposition of Drugs

Methodologies to assess brain drug delivery in lead optimization

Hammarlund-Udenaes, Margareta; Bredberg, Ulf; Fridén, Markus

Ingår i Current Topics in Medicinal Chemistry, s. 148-162, 2009

• DOI för Methodologies to assess brain drug delivery in lead optimization

On the rate and extent of drug delivery to the brain

Hammarlund-Udenaes, Margareta; Fridén, Markus; Syvänen, Stina; Gupta, Anubha

Ingår i Pharmaceutical research, s. 1737-1750, 2008

• DOI för On the rate and extent of drug delivery to the brain

In Vivo Studies of Drug BBB Transport: Translational Challenges and the Role of Brain Imaging

Syvänen, Stina; Hammarlund-Udenaes, Margareta; Loryan, Irena

Ingår i Handbook of Experimental Pharmacology, s. 223-244, Springer, 2022

• DOI för In Vivo Studies of Drug BBB Transport: Translational Challenges and the Role of Brain Imaging

Brain Distribution of Drugs: Pharmacokinetic Considerations

Loryan, Irena; Hammarlund-Udenaes, Margareta; Syvänen, Stina

Ingår i Handbook of Experimental Pharmacology, s. 121-150, Springer, 2022

• DOI för Brain Distribution of Drugs: Pharmacokinetic Considerations

Drug discovery methods for studying brain drug delivery and distribution

Loryan, Irena; Hammarlund-Udenaes, Margareta

Ingår i Drug delivery to the brain, s. 271-316, Springer, 2016

• DOI för Drug discovery methods for studying brain drug delivery and distribution

Pharmacokinetic concepts in brain drug delivery

Hammarlund-Udenaes, Margareta

Ingår i Drug delivery to the brain, s. 127-162, Springer, 2014

• DOI för Pharmacokinetic concepts in brain drug delivery

In vivo approaches to assessing the blood-brain barrier

Hammarlund-Udenaes, Margareta

Ingår i The blood-brain barrier (BBB), s. 21-48, Springer, 2014

• DOI för In vivo approaches to assessing the blood-brain barrier

Microdialysis in CNS PKPD Research: Unraveling Unbound Concentrations

Hammarlund-Udenaes, Margareta

Ingår i Microdialysis in Drug Development, s. 83-102, Springer, 2013

• DOI för Microdialysis in CNS PKPD Research: Unraveling Unbound Concentrations

Microdialysis in CNS PKPD research: Unraveling unbound concentrations

Hammarlund-Udenaes, Margareta

Ingår i Microdialysis in drug development, s. 83-102, Springer, 2013

• DOI för Microdialysis in CNS PKPD research: Unraveling unbound concentrations

Current and retrospective antipsychotic drug use in relation to treatment response in a naturalistic setting of psychotic patients

Alenius, Malin; Hartvig Honoré, Per; Lindström, Leif; Hammarlund-Udenaes, Margareta

2009

Species differences in blood-brain barrier transport of three PET radiotracers with emphasis on P-glycoprotein and plasma protein binding

Syvänen, Stina; Lindhe, Örjan; Palner, Mikael; Kornum, Birgitte R. et al.

Effects of pharmacists’ interventions on appropriateness of prescribing for elderly and exploration of a possible correlation between scores for appropriateness and clinical outcomes: analyses from a randomized controlled trial

Gillespie, Ulrika; Alassaad, Anna; Melhus, Håkan; Mörlin, Claes et al.

Dual behavior of cyclic peptides at the blood-brain barrier vs brain cellular uptake: Importance for CNS drug development

Melander, Erik; Eriksson, Camilla; Wellens, Sara; Culot, Maxime et al.

Cellular uptake and intra-brain distribution of cyclic cell penetrating peptides: why tissue and cell type matters

Melander, Erik; Hosseini, Kimia; Eriksson, Camilla; Fredriksson, Robert et al.

Drug Delivery to the Brain: Physiological Concepts, Methodologies and Approaches

Hammarlund-Udenaes, Margareta; de Lange, Elizabeth; Thorne, Robert G.

Springer-Verlag New York, 2014

• DOI för Drug Delivery to the Brain: Physiological Concepts, Methodologies and Approaches