Diarmaid Hughes

The COMBINE pneumonia model: a multicenter study to standardize a mouse pneumonia model with Pseudomonas aeruginosa and Klebsiella pneumoniae for antibiotic development

Hansen, Jon U.; Arrazuria, Rakel; Hoover, Jennifer L.; Kerscher, Bernhard et al.

Ingår i Microbiology Spectrum, 2026

• DOI för The COMBINE pneumonia model: a multicenter study to standardize a mouse pneumonia model with Pseudomonas aeruginosa and Klebsiella pneumoniae for antibiotic development
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Integrated conjugative elements drive the formation of pandemic clones of Escherichia coli with hybrid chromosomes

Berruga Fernández, Talia; Huseby, Douglas L.; Koshla, Oksana; Shaukat, Anum et al.

Ingår i Molecular biology and evolution, 2026

• DOI för Integrated conjugative elements drive the formation of pandemic clones of Escherichia coli with hybrid chromosomes
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Model-informed drug development for antimicrobials: translational pharmacokinetic-pharmacodynamic modelling of apramycin to facilitate prediction of efficacious dose in complicated urinary tract infections

Hernández-Lozano, Irene; Aranzana-Climent, Vincent; Cao, Sha; Matias, Carina et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 301-310, 2025

• DOI för Model-informed drug development for antimicrobials: translational pharmacokinetic-pharmacodynamic modelling of apramycin to facilitate prediction of efficacious dose in complicated urinary tract infections
• Ladda ner fulltext (pdf) av Model-informed drug development for antimicrobials: translational pharmacokinetic-pharmacodynamic modelling of apramycin to facilitate prediction of efficacious dose in complicated urinary tract infections

Impact of early-life human microbiota on the murine host metabolome: insights from a two-generation HMA mouse model and implications for allergic disease

de Jong, Ymke A.; Seren, Rana M.; Ramsak Marceta, Vida; Checa, Antonio et al.

Ingår i BMC Microbiology, 2025

• DOI för Impact of early-life human microbiota on the murine host metabolome: insights from a two-generation HMA mouse model and implications for allergic disease
• Ladda ner fulltext (pdf) av Impact of early-life human microbiota on the murine host metabolome: insights from a two-generation HMA mouse model and implications for allergic disease

Repurposing zidovudine and 5-fluoro-2′-deoxyuridine as antibiotic drugs made possible by synergy with both trimethoprim and the mitochondrial toxicity–reducing agent uridine

Levenfors, Jolanta J.; Bjerketorp, Joakim; Guss, Bengt; Nord, Christina et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 509-517, 2024

• DOI för Repurposing zidovudine and 5-fluoro-2′-deoxyuridine as antibiotic drugs made possible by synergy with both trimethoprim and the mitochondrial toxicity–reducing agent uridine
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The COMBINE pneumonia model: a multicenter study to standardize a mouse pneumonia model with Pseudomonas aeruginosa and Klebsiella pneumoniae for antibiotic development

Hansen, Jon U.; Arrazuria, Rakel; Hoover, Jennifer L.; Kerscher, Bernhard et al.

Ingår i Microbiology Spectrum, 2026

• DOI för The COMBINE pneumonia model: a multicenter study to standardize a mouse pneumonia model with Pseudomonas aeruginosa and Klebsiella pneumoniae for antibiotic development
• Ladda ner fulltext (pdf) av The COMBINE pneumonia model: a multicenter study to standardize a mouse pneumonia model with Pseudomonas aeruginosa and Klebsiella pneumoniae for antibiotic development

Integrated conjugative elements drive the formation of pandemic clones of Escherichia coli with hybrid chromosomes

Berruga Fernández, Talia; Huseby, Douglas L.; Koshla, Oksana; Shaukat, Anum et al.

Ingår i Molecular biology and evolution, 2026

• DOI för Integrated conjugative elements drive the formation of pandemic clones of Escherichia coli with hybrid chromosomes
• Ladda ner fulltext (pdf) av Integrated conjugative elements drive the formation of pandemic clones of Escherichia coli with hybrid chromosomes

Model-informed drug development for antimicrobials: translational pharmacokinetic-pharmacodynamic modelling of apramycin to facilitate prediction of efficacious dose in complicated urinary tract infections

Hernández-Lozano, Irene; Aranzana-Climent, Vincent; Cao, Sha; Matias, Carina et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 301-310, 2025

• DOI för Model-informed drug development for antimicrobials: translational pharmacokinetic-pharmacodynamic modelling of apramycin to facilitate prediction of efficacious dose in complicated urinary tract infections
• Ladda ner fulltext (pdf) av Model-informed drug development for antimicrobials: translational pharmacokinetic-pharmacodynamic modelling of apramycin to facilitate prediction of efficacious dose in complicated urinary tract infections

Impact of early-life human microbiota on the murine host metabolome: insights from a two-generation HMA mouse model and implications for allergic disease

de Jong, Ymke A.; Seren, Rana M.; Ramsak Marceta, Vida; Checa, Antonio et al.

Ingår i BMC Microbiology, 2025

• DOI för Impact of early-life human microbiota on the murine host metabolome: insights from a two-generation HMA mouse model and implications for allergic disease
• Ladda ner fulltext (pdf) av Impact of early-life human microbiota on the murine host metabolome: insights from a two-generation HMA mouse model and implications for allergic disease

Repurposing zidovudine and 5-fluoro-2′-deoxyuridine as antibiotic drugs made possible by synergy with both trimethoprim and the mitochondrial toxicity–reducing agent uridine

Levenfors, Jolanta J.; Bjerketorp, Joakim; Guss, Bengt; Nord, Christina et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 509-517, 2024

• DOI för Repurposing zidovudine and 5-fluoro-2′-deoxyuridine as antibiotic drugs made possible by synergy with both trimethoprim and the mitochondrial toxicity–reducing agent uridine
• Ladda ner fulltext (pdf) av Repurposing zidovudine and 5-fluoro-2′-deoxyuridine as antibiotic drugs made possible by synergy with both trimethoprim and the mitochondrial toxicity–reducing agent uridine

Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria

Huseby, Douglas L.; Cao, Sha; Zamaratski, Edouard; Sooriyaarachchi, Sanjeewani et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2024

• DOI för Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria
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Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors

Benediktsdottir, Andrea; Sooriyaarachchi, Sanjeewani; Cao, Sha; Ottosson, Nina E. et al.

Ingår i European Journal of Medicinal Chemistry, 2024

• DOI för Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors
• Ladda ner fulltext (pdf) av Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors

Apramycin efficacy against carbapenem- and aminoglycoside-resistant Escherichia coli and Klebsiella pneumoniae in murine bloodstream infection models

Frimodt-Møller, Niels; Hansen, Jon U.; Plattner, Michel; Huseby, Douglas L. et al.

Ingår i International Journal of Antimicrobial Agents, 2024

• DOI för Apramycin efficacy against carbapenem- and aminoglycoside-resistant Escherichia coli and Klebsiella pneumoniae in murine bloodstream infection models
• Ladda ner fulltext (pdf) av Apramycin efficacy against carbapenem- and aminoglycoside-resistant Escherichia coli and Klebsiella pneumoniae in murine bloodstream infection models

Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model

Zhao, Chenyan; Kristoffersson, Anders N.; Khan, David D.; Lagerbäck, Pernilla et al.

Ingår i Scientific Reports, 2024

• DOI för Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model
• Ladda ner fulltext (pdf) av Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model

Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

Cotman, Andrej Emanuel; Durcik, Martina; Tiz, Davide Benedetto; Fulgheri, Federica et al.

Ingår i Journal of Medicinal Chemistry, s. 1380-1425, 2023

• DOI för Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa
• Ladda ner fulltext (pdf) av Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus

Durcik, Martina; Cotman, Andrej Emanuel; Toplak, Zan; Mozina, Stefan et al.

Ingår i Journal of Medicinal Chemistry, s. 3968-3994, 2023

• DOI för New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus
• Ladda ner fulltext (pdf) av New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus

Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria

Cao, Sha; Brandis, Gerrit; Huseby, Douglas L; Hughes, Diarmaid

Ingår i Molecular biology and evolution, 2022

• DOI för Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria
• Ladda ner fulltext (pdf) av Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria

Evolution of Bacterial Interspecies Hybrids with Enlarged Chromosomes

Bartke, Katrin; Huseby, Douglas L; Brandis, Gerrit; Hughes, Diarmaid

Ingår i Genome Biology and Evolution, 2022

• DOI för Evolution of Bacterial Interspecies Hybrids with Enlarged Chromosomes
• Ladda ner fulltext (pdf) av Evolution of Bacterial Interspecies Hybrids with Enlarged Chromosomes

Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections

Arrazuria, Rakel; Kerscher, Bernhard; Huber, Karen E.; Hoover, Jennifer L. et al.

Ingår i Frontiers in Microbiology, 2022

• DOI för Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections
• Ladda ner fulltext (pdf) av Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections

Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)

Lu, Lu; Åkerbladh, Linda; Ahmad, Shabbir; Konda, Vivek et al.

Ingår i ACS - Infectious Diseases, s. 482-498, 2022

• DOI för Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)
• Ladda ner fulltext (pdf) av Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)

Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia

Aranzana-Climent, Vincent; Hughes, Diarmaid; Cao, Sha; Tomczak, Magdalena et al.

Ingår i Clinical Microbiology and Infection, s. 1367-1374, 2022

• DOI för Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia
• Ladda ner fulltext (pdf) av Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia

Phenotypic and genetic barriers to establishment of horizontally transferred genes encoding ribosomal protection proteins

Yadav, Kavita; Garoff, Linnea; Huseby, Douglas L; Hughes, Diarmaid

Ingår i Journal of Antimicrobial Chemotherapy, s. 1441-1447, 2021

• DOI för Phenotypic and genetic barriers to establishment of horizontally transferred genes encoding ribosomal protection proteins

Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli

Praski Alzrigat, Lisa; Huseby, Douglas L.; Brandis, Gerrit; Hughes, Diarmaid

Ingår i Journal of Antimicrobial Chemotherapy, s. 77-83, 2021

• DOI för Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli
• Ladda ner fulltext (pdf) av Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli

Chromosomal Location Determines the Rate of Intrachromosomal Homologous Recombination in Salmonella

Garmendia, Eva; Brandis, Gerrit; Guy, Lionel; Cao, Sha et al.

Ingår i mBio, 2021

• DOI för Chromosomal Location Determines the Rate of Intrachromosomal Homologous Recombination in Salmonella
• Ladda ner fulltext (pdf) av Chromosomal Location Determines the Rate of Intrachromosomal Homologous Recombination in Salmonella

Genetic Architecture and Fitness of Bacterial Interspecies Hybrids

Bartke, Katrin; Garoff, Linnéa; Huseby, Douglas L; Brandis, Gerrit et al.

Ingår i Molecular biology and evolution, s. 1472-1481, 2021

• DOI för Genetic Architecture and Fitness of Bacterial Interspecies Hybrids
• Ladda ner fulltext (pdf) av Genetic Architecture and Fitness of Bacterial Interspecies Hybrids

ENABLE: an engine for European antibacterial drug discovery and development

Olliver, Marie; Griestop, Laura; Hughes, Diarmaid; Belfrage, Anna Karin et al.

Ingår i Nature reviews. Drug discovery, s. 407-408, 2021

• DOI för ENABLE: an engine for European antibacterial drug discovery and development

Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation

Benediktsdottir, Andrea; Lu, Lu; Cao, Sha; Zamaratski, Edouard et al.

Ingår i European Journal of Medicinal Chemistry, 2021

• DOI för Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation
• Ladda ner fulltext (pdf) av Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation

Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice

Becker, Katja; Aranzana-Climent, Vincent; Cao, Sha; Nilsson, Anna et al.

Ingår i Clinical Microbiology and Infection, s. 1315-1321, 2021

• DOI för Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice
• Ladda ner fulltext (pdf) av Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice

Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis

Becker, Katja; Cao, Sha; Nilsson, Anna; Erlandsson, Maria et al.

Ingår i EBioMedicine, 2021

• DOI för Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis
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Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin

Sou, Tomás; Hansen, Jon; Liepinsh, Edgars; Backlund, Maria et al.

Ingår i Clinical Pharmacology and Therapeutics, s. 1063-1073, 2021

• DOI för Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin
• Ladda ner fulltext (pdf) av Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin

Evaluating the potential efficacy and limitations of a phage for joint antibiotic and phage therapy of Staphylococcus aureus infections

Berryhill, Brandon A.; Huseby, Douglas L; McCall, Ingrid C.; Hughes, Diarmaid et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2021

• DOI för Evaluating the potential efficacy and limitations of a phage for joint antibiotic and phage therapy of Staphylococcus aureus infections
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Expression of the qepA1 gene is induced under antibiotic exposure

Brandis, Gerrit; Gockel, Jonas; Garoff, Linnéa; Guy, Lionel et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 1433-1440, 2021

• DOI för Expression of the qepA1 gene is induced under antibiotic exposure
• Ladda ner fulltext (pdf) av Expression of the qepA1 gene is induced under antibiotic exposure

Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response

Brandis, Gerrit; Granström, Susanna; Leber, Anna T.; Bartke, Katrin et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 606-615, 2021

• DOI för Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response
• Ladda ner fulltext (pdf) av Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response

Isopedopeptins A-H: Cationic Cyclic Lipodepsipeptides from Pedobacter cryoconitis UP508 Targeting WHO Top-Priority Carbapenem-Resistant Bacteria

Nord, Christina; Bjerketorp, Joakim; Levenfors, Jolanta J.; Cao, Sha et al.

Ingår i ACS Chemical Biology, s. 2937-2944, 2020

• DOI för Isopedopeptins A-H: Cationic Cyclic Lipodepsipeptides from Pedobacter cryoconitis UP508 Targeting WHO Top-Priority Carbapenem-Resistant Bacteria
• Ladda ner fulltext (pdf) av Isopedopeptins A-H: Cationic Cyclic Lipodepsipeptides from Pedobacter cryoconitis UP508 Targeting WHO Top-Priority Carbapenem-Resistant Bacteria

The SNAP hypothesis: Chromosomal rearrangements could emerge from positive Selection during Niche Adaptation

Brandis, Gerrit; Hughes, Diarmaid

Ingår i PLOS Genetics, 2020

• DOI för The SNAP hypothesis: Chromosomal rearrangements could emerge from positive Selection during Niche Adaptation
• Ladda ner fulltext (pdf) av The SNAP hypothesis: Chromosomal rearrangements could emerge from positive Selection during Niche Adaptation

Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli

Garoff, Linnéa; Pietsch, Franziska; Huseby, Douglas L; Lilja, Tua et al.

Ingår i Molecular biology and evolution, s. 1637-1646, 2020

• DOI för Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli
• Ladda ner fulltext (pdf) av Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli

Synthesis of New N-Acyl-1,2,3-triazole Chalcones and Determination of Their Antibacterial Activity

Odin, I. S.; Cao, Sha; Hughes, Diarmaid; Zamaratskii, E. V. et al.

Ingår i Doklady. Chemistry, s. 89-92, 2020

• DOI för Synthesis of New N-Acyl-1,2,3-triazole Chalcones and Determination of Their Antibacterial Activity

Structure-activity relationship studies on the inhibition of the bacterial translation of novel Odilorhabdins analogues

Loza, Einars; Sarciaux, Matthieu; Ikaunieks, Martins; Katkevics, Martins et al.

Ingår i Bioorganic & Medicinal Chemistry, 2020

• DOI för Structure-activity relationship studies on the inhibition of the bacterial translation of novel Odilorhabdins analogues

Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene

Huseby, Douglas L; Brandis, Gerrit; Praski Alzrigat, Lisa; Hughes, Diarmaid

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 3185-3191, 2020

• DOI för Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene
• Ladda ner fulltext (pdf) av Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene

Measuring Homologous Recombination Rates between Chromosomal Locations in Salmonella

Brandis, Gerrit; Cao, Sha; Hughes, Diarmaid

Ingår i Bio-protocol, 2019

• DOI för Measuring Homologous Recombination Rates between Chromosomal Locations in Salmonella

Operon Concatenation Is an Ancient Feature That Restricts the Potential to Rearrange Bacterial Chromosomes

Brandis, Gerrit; Cao, Sha; Hughes, Diarmaid

Ingår i Molecular biology and evolution, s. 1990-2000, 2019

• DOI för Operon Concatenation Is an Ancient Feature That Restricts the Potential to Rearrange Bacterial Chromosomes
• Ladda ner fulltext (pdf) av Operon Concatenation Is an Ancient Feature That Restricts the Potential to Rearrange Bacterial Chromosomes

In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii

Juhas, Mario; Widlake, Emma; Teo, Jeanette; Huseby, Douglas L et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 944-952, 2019

• DOI för In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii
• Ladda ner fulltext (pdf) av In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii

Increased expression of Qnr is sufficient to confer clinical resistance to ciprofloxacin in Escherichia coli

Garoff, Linnéa; Yadav, Kavita; Hughes, Diarmaid

Ingår i Journal of Antimicrobial Chemotherapy, s. 348-352, 2018

• DOI för Increased expression of Qnr is sufficient to confer clinical resistance to ciprofloxacin in Escherichia coli
• Ladda ner fulltext (pdf) av Increased expression of Qnr is sufficient to confer clinical resistance to ciprofloxacin in Escherichia coli

Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site

Pantel, Lucile; Florin, Tanja; Dobosz-Bartoszek, Malgorzata; Racine, Emilie et al.

Ingår i Molecular Cell, s. 83-94, 2018

• DOI för Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site

Co-evolution with recombination affects the stability of mobile genetic element insertions within gene families of Salmonella

Brandis, Gerrit; Cao, Sha; Hughes, Diarmaid

Ingår i Molecular Microbiology, s. 697-710, 2018

• DOI för Co-evolution with recombination affects the stability of mobile genetic element insertions within gene families of Salmonella
• Ladda ner fulltext (pdf) av Co-evolution with recombination affects the stability of mobile genetic element insertions within gene families of Salmonella

Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase

Szałaj, Natalia; Lu, Lu; Benediktsdottir, Andrea; Zamaratski, Edouard et al.

Ingår i European Journal of Medicinal Chemistry, s. 1346-1360, 2018

• DOI för Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase

Muramyl Endopeptidase Spr Contributes to Intrinsic Vancomycin Resistance in Salmonella enterica Serovar Typhimurium

Vestö, Kim; Huseby, Douglas L; Snygg, Lina; Wang, Helen et al.

Ingår i Frontiers in Microbiology, 2018

• DOI för Muramyl Endopeptidase Spr Contributes to Intrinsic Vancomycin Resistance in Salmonella enterica Serovar Typhimurium
• Ladda ner fulltext (pdf) av Muramyl Endopeptidase Spr Contributes to Intrinsic Vancomycin Resistance in Salmonella enterica Serovar Typhimurium

Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB.

Brandis, Gerrit; Hughes, Diarmaid

Ingår i Scientific Reports, 2018

• DOI för Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB.
• Ladda ner fulltext (pdf) av Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB.

Methods to determine mutational trajectories after experimental evolution of antibiotic resistance.

Huseby, Douglas L; Hughes, Diarmaid

Ingår i Methods in Molecular Biology, s. 95-103, 2018

• DOI för Methods to determine mutational trajectories after experimental evolution of antibiotic resistance.

Effect of aminoacyl-tRNA synthetase mutations on susceptibility to ciprofloxacin in Escherichia coli

Garoff, Linnéa; Huseby, Douglas L; Praski Alzrigat, Lisa; Hughes, Diarmaid

Ingår i Journal of Antimicrobial Chemotherapy, s. 3285-3292, 2018

• DOI för Effect of aminoacyl-tRNA synthetase mutations on susceptibility to ciprofloxacin in Escherichia coli
• Ladda ner fulltext (pdf) av Effect of aminoacyl-tRNA synthetase mutations on susceptibility to ciprofloxacin in Escherichia coli

Transcriptional Regulation Buffers Gene Dosage Effects on a Highly Expressed Operon in Salmonella

Garmendia, Eva; Brandis, Gerrit; Hughes, Diarmaid

Ingår i mBio, 2018

• DOI för Transcriptional Regulation Buffers Gene Dosage Effects on a Highly Expressed Operon in Salmonella
• Ladda ner fulltext (pdf) av Transcriptional Regulation Buffers Gene Dosage Effects on a Highly Expressed Operon in Salmonella

Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones

Jeannot, Frédéric; Taillier, Thomas; Despeyroux, Pierre; Renard, Stéphane et al.

Ingår i Journal of Medicinal Chemistry, s. 3565-3581, 2018

• DOI för Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones

Predicting mutant selection in competition experiments with ciprofloxacin-exposed Escherichia coli

Khan, David; Lagerbäck, Pernilla; Malmberg, Christer; Kristoffersson, Anders et al.

Ingår i International Journal of Antimicrobial Agents, s. 399-406, 2018

• DOI för Predicting mutant selection in competition experiments with ciprofloxacin-exposed Escherichia coli

Mutation supply and relative fitness shape the genotypes of ciprofloxacin-resistant Escherichia coli

Huseby, Douglas L.; Pietsch, Franziska; Brandis, Gerrit; Garoff, Linnéa et al.

Ingår i Molecular biology and evolution, s. 1029-1039, 2017

• DOI för Mutation supply and relative fitness shape the genotypes of ciprofloxacin-resistant Escherichia coli
• Ladda ner fulltext (pdf) av Mutation supply and relative fitness shape the genotypes of ciprofloxacin-resistant Escherichia coli

The processive kinetics of gene conversion in bacteria

Paulsson, Johan; El Karoui, Meriem; Lindell, Monica; Hughes, Diarmaid

Ingår i Molecular Microbiology, s. 752-760, 2017

• DOI för The processive kinetics of gene conversion in bacteria
• Ladda ner fulltext (pdf) av The processive kinetics of gene conversion in bacteria

Early-Life Human Microbiota Associated With Childhood Allergy Promotes the T Helper 17 Axis in Mice

Petursdottir, Dagbjort H.; Nordlander, Sofia; Qazi, Khaleda Rahman; Carvalho-Queiroz, Claudia et al.

Ingår i Frontiers in Immunology, 2017

• DOI för Early-Life Human Microbiota Associated With Childhood Allergy Promotes the T Helper 17 Axis in Mice
• Ladda ner fulltext (pdf) av Early-Life Human Microbiota Associated With Childhood Allergy Promotes the T Helper 17 Axis in Mice

Selection and Transmission of Antibiotic-Resistant Bacteria

Andersson, Dan I; Hughes, Diarmaid

Ingår i Microbiology Spectrum, 2017

• DOI för Selection and Transmission of Antibiotic-Resistant Bacteria

Ciprofloxacin selects for RNA polymerase mutations with pleiotropic antibiotic resistance effects

Pietsch, Franziska; Bergman, Jessica M.; Brandis, Gerrit; Marcusson, Linda L. et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 75-84, 2017

• DOI för Ciprofloxacin selects for RNA polymerase mutations with pleiotropic antibiotic resistance effects

Can a pharmacokinetic/pharmacodynamic (PKPD) model be predictive across bacterial densities and strains?: External evaluation of a PKPD model describing longitudinal in vitro data

Nielsen, Elisabet I.; Khan, David D.; Cao, Sha; Lustig, Ulrika et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 3108-3116, 2017

• DOI för Can a pharmacokinetic/pharmacodynamic (PKPD) model be predictive across bacterial densities and strains?: External evaluation of a PKPD model describing longitudinal in vitro data

Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)

De Rosa, Maria; Lu, Lu; Zamaratski, Edouard; Szałaj, Natalia et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 897-911, 2017

• DOI för Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)
• Ladda ner fulltext (pdf) av Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)

Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli: Multiple Antibiotic-Resistance, Gram-Negative Bacteria, Multidrug Efflux Pump, Urinary-Tract-Infections, Fluoroquinolone Resistance, Quinolone Resistance, Mechanisms, Expression, Sequence, Soxs

Praski Alzrigat, Lisa; Huseby, Douglas L; Brandis, Gerrit; Hughes, Diarmaid

Ingår i Journal of Antimicrobial Chemotherapy, s. 3016-3024, 2017

• DOI för Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli: Multiple Antibiotic-Resistance, Gram-Negative Bacteria, Multidrug Efflux Pump, Urinary-Tract-Infections, Fluoroquinolone Resistance, Quinolone Resistance, Mechanisms, Expression, Sequence, Soxs
• Ladda ner fulltext (pdf) av Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli: Multiple Antibiotic-Resistance, Gram-Negative Bacteria, Multidrug Efflux Pump, Urinary-Tract-Infections, Fluoroquinolone Resistance, Quinolone Resistance, Mechanisms, Expression, Sequence, Soxs

Having your cake and eating it - Staphylococcus aureus small colony variants can evolve faster growth rate without losing their antibiotic resistance

Brandis, Gerrit; Cao, Sha; Huseby, Douglas L.; Hughes, Diarmaid

Ingår i MICROBIAL CELL, s. 275-277, 2017

• DOI för Having your cake and eating it - Staphylococcus aureus small colony variants can evolve faster growth rate without losing their antibiotic resistance
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Functional Constraints on Replacing an Essential Gene with Its Ancient and Modern Homologs

Kacar, Betül; Garmendia, Eva; Tuncbag, Nurcan; Andersson, Dan I et al.

Ingår i mBio, 2017

• DOI för Functional Constraints on Replacing an Essential Gene with Its Ancient and Modern Homologs

Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus

Cao, Sha; Huseby, Douglas L; Brandis, Gerrit; Hughes, Diarmaid

Ingår i mBio, 2017

• DOI för Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus
• Ladda ner fulltext (pdf) av Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus

Bacterial pathogens, antibiotics and antibiotic resistance: Editorial

Banin, Ehud; Hughes, Diarmaid; Kuipers, Oscar P.

Ingår i FEMS Microbiology Reviews, s. 450-452, 2017

• DOI för Bacterial pathogens, antibiotics and antibiotic resistance: Editorial

The Selective Advantage of Synonymous Codon Usage Bias in Salmonella

Brandis, Gerrit; Hughes, Diarmaid

Ingår i PLOS Genetics, 2016

• DOI för The Selective Advantage of Synonymous Codon Usage Bias in Salmonella
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Evidence for the critical role of a secondary site rpoB mutation in the compensatory evolution and successful transmission of an MDR tuberculosis outbreak strain

Meftahi, Nedra; Namouchi, Amine; Mhenni, Besma; Brandis, Gerrit et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 324-332, 2016

• DOI för Evidence for the critical role of a secondary site rpoB mutation in the compensatory evolution and successful transmission of an MDR tuberculosis outbreak strain

Autoregulation of the tufB operon in Salmonella

Brandis, Gerrit; Bergman, Jessica M.; Hughes, Diarmaid

Ingår i Molecular Microbiology, s. 1004-1016, 2016

• DOI för Autoregulation of the tufB operon in Salmonella

Discovery and structure-activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors

Cooper, Ian R.; McCarroll, Andrew J.; McGarry, David; Kirkham, James et al.

Ingår i Bioorganic & Medicinal Chemistry Letters, s. 4179-4183, 2016

• DOI för Discovery and structure-activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors

Genetics: Location affects sporulation

Lazazzera, Beth A; Hughes, Diarmaid

Ingår i Nature, s. 42-43, 2015

• DOI för Genetics: Location affects sporulation

Comprehensive phenotypic characterization of rifampicin resistance mutations in Salmonella provides insight into the evolution of resistance in Mycobacterium tuberculosis

Brandis, Gerrit; Pietsch, Franziska; Alemayehu, Rahel; Hughes, Diarmaid

Ingår i Journal of Antimicrobial Chemotherapy, s. 680-685, 2015

• DOI för Comprehensive phenotypic characterization of rifampicin resistance mutations in Salmonella provides insight into the evolution of resistance in Mycobacterium tuberculosis

A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants

Khan, David D.; Lagerbäck, Pernilla; Cao, Sha; Lustig, Ulrika et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 3051-3060, 2015

• DOI för A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants

Turnover of mRNAs is one of the essential functions of RNase E

Larsson Hammarlöf, Disa; Bergman, Jessica M.; Garmendia, Eva; Hughes, Diarmaid

Ingår i Molecular Microbiology, s. 34-45, 2015

• DOI för Turnover of mRNAs is one of the essential functions of RNase E

Reducing ppGpp Level Rescues an Extreme Growth Defect Caused by Mutant EF-Tu

Bergman, Jessica; Hammarlöf, Disa L; Hughes, Diarmaid

Ingår i PLOS ONE, 2014

• DOI för Reducing ppGpp Level Rescues an Extreme Growth Defect Caused by Mutant EF-Tu
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Acetate availability and utilization supports the growth of mutant sub-populations on aging bacterial colonies

Bergman, Jessica M; Wrande, Marie; Hughes, Diarmaid

Ingår i PLOS ONE, 2014

• DOI för Acetate availability and utilization supports the growth of mutant sub-populations on aging bacterial colonies
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Mutant prevention concentrations of pradofloxacin for susceptible and mutant strains of Escherichia coli with reduced fluoroquinolone susceptibility

Marcusson, Linda L.; Lindgren, Patricia Komp; Olofsson, Sara K.; Hughes, Diarmaid et al.

Ingår i International Journal of Antimicrobial Agents, s. 354-357, 2014

• DOI för Mutant prevention concentrations of pradofloxacin for susceptible and mutant strains of Escherichia coli with reduced fluoroquinolone susceptibility

Cell-wall-inhibiting antibiotic combinations with activity against multidrug-resistant Klebsiella pneumoniae and Escherichia coli

Hickman, Rachel A.; Hughes, Diarmaid; Cars, Thomas; Malmberg, Christer et al.

Ingår i Clinical Microbiology and Infection, 2014

• DOI för Cell-wall-inhibiting antibiotic combinations with activity against multidrug-resistant Klebsiella pneumoniae and Escherichia coli

Genetic characterization of compensatory evolution in strains carrying rpoB Ser531Leu, the rifampicin resistance mutation most frequently found in clinical isolates

Brandis, Gerrit; Hughes, Diarmaid

Ingår i Journal of Antimicrobial Chemotherapy, s. 2493-2497, 2013

• DOI för Genetic characterization of compensatory evolution in strains carrying rpoB Ser531Leu, the rifampicin resistance mutation most frequently found in clinical isolates

Fitness-compensatory mutations in rifampicin-resistant RNA polymerase

Brandis, Gerrit; Wrande, Marie; Liljas, Lars; Hughes, Diarmaid

Ingår i Molecular Microbiology, s. 142-151, 2012

• DOI för Fitness-compensatory mutations in rifampicin-resistant RNA polymerase

Genome-Wide Detection of Spontaneous Chromosomal Rearrangements in Bacteria

Sun, Song; Ke, Rongqin; Hughes, Diarmaid; Nilsson, Mats et al.

Ingår i PLOS ONE, 2012

• DOI för Genome-Wide Detection of Spontaneous Chromosomal Rearrangements in Bacteria
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Fitness cost: a bacteriological explanation for the demise of the first international methicillin-resistant Staphylococcus aureus epidemic

Nielsen, Karen L.; Pedersen, Thomas M.; Udekwu, Klas I.; Petersen, Andreas et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 1325-1332, 2012

• DOI för Fitness cost: a bacteriological explanation for the demise of the first international methicillin-resistant Staphylococcus aureus epidemic

Selection of resistance at lethal and non-lethal antibiotic concentrations

Hughes, Diarmaid; Andersson, Dan I

Ingår i Current Opinion in Microbiology, s. 555-560, 2012

• DOI för Selection of resistance at lethal and non-lethal antibiotic concentrations

Evolution of antibiotic resistance at non-lethal drug concentrations.

Andersson, Dan I; Hughes, Diarmaid

Ingår i Drug resistance updates, s. 162-172, 2012

• DOI för Evolution of antibiotic resistance at non-lethal drug concentrations.

Selection of Resistant Bacteria at Very Low Antibiotic Concentrations

Gullberg, Erik; Cao, Sha; Berg, Otto G.; Ilbäck, Carolina et al.

Ingår i PLoS pathogens, 2011

• DOI för Selection of Resistant Bacteria at Very Low Antibiotic Concentrations

Genetic Complexity of Fusidic Acid-Resistant Small Colony Variants (SCV) in Staphylococcus aureus

Lannergård, Jonas; Cao, Sha; Norström, Tobias; Delgado, Alejandro et al.

Ingår i PLOS ONE, 2011

• DOI för Genetic Complexity of Fusidic Acid-Resistant Small Colony Variants (SCV) in Staphylococcus aureus

Can phylogenetic type predict resistance development?

Nazir, Humera; Cao, Sha; Hasan, Fariha; Hughes, Diarmaid

Ingår i Journal of Antimicrobial Chemotherapy, s. 778-787, 2011

• DOI för Can phylogenetic type predict resistance development?

Intra- and Extracellular Activities of Dicloxacillin and Linezolid against a Clinical Staphylococcus aureus Strain with a Small-Colony-Variant Phenotype in an In Vitro Model of THP-1 Macrophages and an In Vivo Mouse Peritonitis Model

Sandberg, Anne; Lemaire, Sandrine; Van Bambeke, Françoise; Tulkens, Paul M. et al.

Ingår i Antimicrobial Agents and Chemotherapy, s. 1443-1452, 2011

• DOI för Intra- and Extracellular Activities of Dicloxacillin and Linezolid against a Clinical Staphylococcus aureus Strain with a Small-Colony-Variant Phenotype in an In Vitro Model of THP-1 Macrophages and an In Vivo Mouse Peritonitis Model

Temperature-sensitive mutants of RNase E in Salmonella enterica

Hammarlöf, Disa L.; Liljas, Lars; Hughes, Diarmaid

Ingår i Journal of Bacteriology, s. 6639-6650, 2011

• DOI för Temperature-sensitive mutants of RNase E in Salmonella enterica

Can phylogenetic type predict resistance development?

Nazir, Humera; Cao, Sha; Hasan, Fariha; Hughes, Diarmaid

Ingår i Journal of Antimicrobial Chemotherapy, s. 778-787, 2011

• DOI för Can phylogenetic type predict resistance development?

Effect of the translesion DNA polymerases, endonucleases and RpoS on mutation rates in Salmonella typhimurium

Koskiniemi, Sanna; Hughes, Diarmaid; Andersson, Dan I

Ingår i Genetics, s. 783-795, 2010

• DOI för Effect of the translesion DNA polymerases, endonucleases and RpoS on mutation rates in Salmonella typhimurium

Genetic Determinants of Resistance to Fusidic Acid among Clinical Bacteremia Isolates of Staphylococcus aureus

Lannergård, Jonas; Norström, Tobias; Hughes, Diarmaid

Ingår i Antimicrobial Agents and Chemotherapy, s. 2059-2065, 2009

• DOI för Genetic Determinants of Resistance to Fusidic Acid among Clinical Bacteremia Isolates of Staphylococcus aureus

Interplay in the Selection of Fluoroquinolone Resistance and Bacterial Fitness

Marcusson, Linda L; Frimodt-Møller, Niels; Hughes, Diarmaid

Ingår i PLoS Pathogens, 2009

• DOI för Interplay in the Selection of Fluoroquinolone Resistance and Bacterial Fitness

Identification of the Genetic Basis for Clinical Menadione-Auxotrophic Small-Colony Variant Isolates of Staphylococcus aureus

Lannergård, Jonas; von Eiff, Christof; Sander, Gunnar; Cordes, Tina et al.

Ingår i Antimicrobial Agents and Chemotherapy, s. 4017-4022, 2008

• DOI för Identification of the Genetic Basis for Clinical Menadione-Auxotrophic Small-Colony Variant Isolates of Staphylococcus aureus

Accumulation of mutants in "aging" bacterial colonies is due to growth under selection, not stress-induced mutagenesis

Wrande, Marie; Roth, John R.; Hughes, Diarmaid

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 11863-11868, 2008

• DOI för Accumulation of mutants in "aging" bacterial colonies is due to growth under selection, not stress-induced mutagenesis

Mutants of the RNA-processing enzyme RNase E reverse the extreme slow-growth phenotype caused by a mutant translation factor EF-Tu

Hammarlöf, Disa L; Hughes, Diarmaid

Ingår i Molecular Microbiology, s. 1194-1209, 2008

• DOI för Mutants of the RNA-processing enzyme RNase E reverse the extreme slow-growth phenotype caused by a mutant translation factor EF-Tu

Dose-related selection of fluoroquinolone-resistant Escherichia coli

Olofsson, Sara K; Marcusson, Linda L.; Strömbäck, Ann; Hughes, Diarmaid et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 795-801, 2007

• DOI för Dose-related selection of fluoroquinolone-resistant Escherichia coli

Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus

Norström, Tobias; Lannergård, Jonas; Hughes, Diarmaid

Ingår i Antimicrobial Agents and Chemotherapy, s. 4438-4446, 2007

• DOI för Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus

Selection of ciprofloxacin resistance in Escherichia coli in an in vitro kinetic model: relation between drug exposure and mutant prevention concentration

Olofsson, Sara K; Marcusson, Linda L; Komp Lindgren, Patricia; Hughes, Diarmaid et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 1116-1121, 2006

• DOI för Selection of ciprofloxacin resistance in Escherichia coli in an in vitro kinetic model: relation between drug exposure and mutant prevention concentration

Weak mutators can drive the evolution of fluoroquinolone resistance in Escherichia coli

Örlén, Hanna; Hughes, Diarmaid

Ingår i Antimicrobial Agents and Chemotherapy, s. 3454-3456, 2006

• DOI för Weak mutators can drive the evolution of fluoroquinolone resistance in Escherichia coli

Biological cost of single and multiple norfloxacin resistance mutations in Escherichia coli implicated in urinary tract infections

Komp Lindgren, Patricia; Marcusson, Linda L; Sandvang, Dorthe; Fridmodt-Møller, Niels et al.

Ingår i Antimicrobial Agents and Chemotherapy, s. 2343-2351, 2005

• DOI för Biological cost of single and multiple norfloxacin resistance mutations in Escherichia coli implicated in urinary tract infections

Mutant prevention concentrations of ciprofloxacin for urinary tract infection isolates of Escherichia coli

Marcusson, Linda L; Olofsson, Sara K; Komp Lindgren, Patricia; Cars, Otto et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 938-943, 2005

• DOI för Mutant prevention concentrations of ciprofloxacin for urinary tract infection isolates of Escherichia coli

Establishment of a superficial skin infection model in mice by using Staphylococcus aureus and Streptococcus pyogenes

Kugelberg, Elisabeth; Norström, Tobias; Petersen, Thomas K; Duvold, Tore et al.

Ingår i Antimicrobial Agents and Chemotherapy, s. 3435-3441, 2005

• DOI för Establishment of a superficial skin infection model in mice by using Staphylococcus aureus and Streptococcus pyogenes

Hyper-susceptibility of a fusidic acid-resistant mutant of Salmonella to different classes of antibiotics

Macvanin, Mirjana; Hughes, Diarmaid

Ingår i FEMS Microbiology Letters, s. 215-220, 2005

• DOI för Hyper-susceptibility of a fusidic acid-resistant mutant of Salmonella to different classes of antibiotics

Fusidic acid-resistant mutants of Salmonella enterica serovar typhimurium have low levels of heme and a reduced rate of respiration and are sensitive to oxidative stress

Macvanin, Mirjana; Ballagi, Andras; Hughes, Diarmaid

Ingår i Antimicrobial Agents and Chemotherapy, s. 3877-3883, 2004

• DOI för Fusidic acid-resistant mutants of Salmonella enterica serovar typhimurium have low levels of heme and a reduced rate of respiration and are sensitive to oxidative stress

Evidence against reciprocal recombination as the basis for tuf gene conversion in Salmonella enterica serovar Typhimurium

Arwidsson, Ola; Hughes, Diarmaid

Ingår i Journal of Molecular Biology, s. 463-467, 2004

• DOI för Evidence against reciprocal recombination as the basis for tuf gene conversion in Salmonella enterica serovar Typhimurium

Fusidic acid-resistant mutants of Salmonella enterica serovar Typhimurium with low fitness in vivo are defective in RpoS induction

Macvanin, Mirjana; Björkman, Johanna; Eriksson, Sofia; Rhen, Mikael et al.

Ingår i Antimicrobial Agents and Chemotherapy, s. 3743-3749, 2003

• DOI för Fusidic acid-resistant mutants of Salmonella enterica serovar Typhimurium with low fitness in vivo are defective in RpoS induction

Mutation Rate and Evolution of Fluoroquinolone Resistance in Escherichia coli Isolates from Patients with Urinary tract infections

Komp Lindgren, Patricia; Karlsson, Åsa; Hughes, Diarmaid

Ingår i Antimicrobial Agents and Chemotherapy, s. 3222-3232, 2003

• DOI för Mutation Rate and Evolution of Fluoroquinolone Resistance in Escherichia coli Isolates from Patients with Urinary tract infections

Biological cost and compensatory evolution in fusidic acid-resistant Staphylococcus aureus

Nagaev, Ivan; Björkman, Johanna; Andersson, Dan I; Hughes, Diarmaid

Ingår i Molecular Microbiology, s. 433-439, 2001

• DOI för Biological cost and compensatory evolution in fusidic acid-resistant Staphylococcus aureus

Fusidic acid-resistant EF-G perturbs the accumulation of ppGpp

Macvanin, Mirjana; Johanson, Urban; Ehrenberg, Måns; Hughes, Diarmaid

Ingår i Molecular Microbiology, s. 98-107, 2000

• DOI för Fusidic acid-resistant EF-G perturbs the accumulation of ppGpp

Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site

Laurberg, M; Kristensen, O; Martemyanov, K; Gudkov, A.T et al.

Ingår i Journal of Molecular Biology, s. 593-603, 2000

• DOI för Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site

Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance

Björkman, J; Nagaev, I; Berg, O G; Hughes, Diarmaid et al.

Ingår i Science, s. 1479-1482, 2000

• DOI för Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance

Co-evolution of the tuf genes links gene conversion with the generation of chromosomal inversions

Hughes, Diarmaid

Ingår i Journal of Molecular Biology, s. 355-364, 2000

• DOI för Co-evolution of the tuf genes links gene conversion with the generation of chromosomal inversions

Novel ribosomal mutations affecting translational accuracy, antibiotic resistance and virulence of Salmonella typhimurium

Björkman, Johanna; Samuelsson, Patrik; Andersson, Dan I.; Hughes, Diarmaid

Ingår i Molecular Microbiology, s. 53-58, 1999

• DOI för Novel ribosomal mutations affecting translational accuracy, antibiotic resistance and virulence of Salmonella typhimurium

Virulence of antibiotic-resistant Salmonella typhimurium

Bjorkman, J; Hughes, Diarmaid; Andersson, DI

Ingår i PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, s. 3949-3953, 1998

Carbon starvation of Salmonella typhimurium does not cause a general increase of mutation rates

Hughes, Diarmaid; Andersson, DI

Ingår i JOURNAL OF BACTERIOLOGY, s. 6688-6691, 1997

Homologous recombination between the tuf genes of Salmonella typhimurium

Abdulkarim, Farhad; Hughes, Diarmaid

Ingår i Journal of Molecular Biology, s. 506-522, 1996

• DOI för Homologous recombination between the tuf genes of Salmonella typhimurium

Muller's ratchet decreases fitness of a DNA-based microbe

Andersson, Dan I; Hughes, Diarmaid

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 906-907, 1996

Mutants of EF-Tu defective in binding aminoacyl-tRNA

Abdulkarim, Farhad; Ehrenberg, Måns; Hughes, Diarmaid

Ingår i FEBS Letters, s. 297-303, 1996

• DOI för Mutants of EF-Tu defective in binding aminoacyl-tRNA

The dynamic structure of EF-G studied by fusidic acid resistance and internal revertants

Johanson, U; AEvarsson, A; Liljas, A; Hughes, Diarmaid

Ingår i JOURNAL OF MOLECULAR BIOLOGY, s. 420-432, 1996

A new mutation in 16S rRNA of Escherichia coli conferring spectinomycin resistance

Johanson, Urban; Hughes, Diarmaid

Ingår i Nucleic Acids Research, s. 464-466, 1995

Fusidic acid-resistant mutants define three regions in elongation factor G of Salmonella typhimurium

Johanson, Urban; Hughes, Diarmaid

Ingår i Gene, s. 55-59, 1994

• DOI för Fusidic acid-resistant mutants define three regions in elongation factor G of Salmonella typhimurium

Mutations to kirromycin resistance occur in the interface of domains I and III of EF-Tu.GTP

Abdulkarim, Farhad; Liljas, Lars; Hughes, Diarmaid

Ingår i FEBS Letters, s. 118-122, 1994

• DOI för Mutations to kirromycin resistance occur in the interface of domains I and III of EF-Tu.GTP

Suppression of rpsL phenotypes by tuf mutations reveals a unique relationship between translation elongation and growth rate

Tubulekas, Ioannis; Hughes, Diarmaid

Ingår i Molecular Microbiology, s. 275-284, 1993

• DOI för Suppression of rpsL phenotypes by tuf mutations reveals a unique relationship between translation elongation and growth rate

Growth and translation elongation rate are sensitive to the concentration of EF-Tu

Tubulekas, Ioannis; Hughes, Diarmaid

Ingår i Molecular Microbiology, s. 761-770, 1993

• DOI för Growth and translation elongation rate are sensitive to the concentration of EF-Tu

A single amino acid substitution in elongation factor Tu disrupts interaction between the ternary complex and the ribosome

Tubulekas, I; Hughes, Diarmaid

Ingår i Journal of Bacteriology, s. 240-250, 1993

Comparison of the complete sequence of the str operon in Salmonella typhimurium and Escherichia coli

Johanson, Urban; Hughes, Diarmaid

Ingår i Gene, s. 93-98, 1992

• DOI för Comparison of the complete sequence of the str operon in Salmonella typhimurium and Escherichia coli

Mutant ribosomes can generate dominant kirromycin resistance

Tubulekas, Ioannis; Buckingham, Richard H.; Hughes, Diarmaid

Ingår i Journal of Bacteriology, s. 3635-3643, 1991

Error-prone EF-Tu reduces in vivo enzyme activity and cellular growth rate

Hughes, Diarmaid

Ingår i Molecular Microbiology, s. 623-630, 1991

The nucleotide sequence of rpsL and its flanking regions in Salmonella typhimurium

Hughes, Diarmaid; Buckingham, RH

Ingår i Gene, s. 123-124, 1991

• DOI för The nucleotide sequence of rpsL and its flanking regions in Salmonella typhimurium

Missense substitutions lethal to essential functions of EF-Tu

Abdulkarim, Farhad; Tuohy, TMF; Buckingham, RH; Hughes, Diarmaid

Ingår i Biochimie, s. 1457-1464, 1991

• DOI för Missense substitutions lethal to essential functions of EF-Tu

Both genes for EF-Tu in Salmonella typhimurium are individually dispensible for growth

Hughes, Diarmaid

Ingår i Journal of Molecular Biology, s. 41-51, 1990

• DOI för Both genes for EF-Tu in Salmonella typhimurium are individually dispensible for growth

Overproduction of release factor reduces spontaneous frameshifting and frameshift suppression by mutant elongation factor Tu

Rydén Aulin, Monica; Hughes, Diarmaid

Ingår i Journal of Bacteriology, s. 6721-6726, 1990

The role of EF-Tu and other translation components in determining translocation step size

Tuohy, TMF; Thompson, S; Gesteland, R; Hughes, Diarmaid et al.

Ingår i Biochimica et Biophysica Acta, Gene Structure and Expression, s. 274-278, 1990

• DOI för The role of EF-Tu and other translation components in determining translocation step size

Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents

Arrazuria, Rakel; Kerscher, Bernhard; Huber, Karen E.; Hoover, Jennifer L. et al.

Ingår i Frontiers in Microbiology, 2022

• DOI för Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents
• Ladda ner fulltext (pdf) av Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents

Evolutionary Trajectories to Antibiotic Resistance

Hughes, Diarmaid; Andersson, Dan I

Ingår i Annual Review of Microbiology, s. 579-596, 2017

• DOI för Evolutionary Trajectories to Antibiotic Resistance

Environmental and genetic modulation of the phenotypic expression of antibiotic resistance

Hughes, Diarmaid; Andersson, Dan I

Ingår i FEMS Microbiology Reviews, s. 374-391, 2017

• DOI för Environmental and genetic modulation of the phenotypic expression of antibiotic resistance

Using the power of genetic suppressors to probe the essential functions of RNase E

Hughes, Diarmaid

Ingår i Current Genetics, s. 53-57, 2016

• DOI för Using the power of genetic suppressors to probe the essential functions of RNase E

Mechanisms and consequences of bacterial resistance to antimicrobial peptides

Andersson, Dan I.; Hughes, Diarmaid; Kubicek-Sutherland, Jessica Z.

Ingår i Drug resistance updates, s. 43-57, 2016

• DOI för Mechanisms and consequences of bacterial resistance to antimicrobial peptides
• Ladda ner fulltext (pdf) av Mechanisms and consequences of bacterial resistance to antimicrobial peptides

Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms

Hughes, Diarmaid; Andersson, Dan I.

Ingår i Nature reviews genetics, s. 459-471, 2015

• DOI för Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms

Selection and Evolution of Resistance to Antimicrobial Drugs

Hughes, Diarmaid

Ingår i IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, s. 521-529, 2014

• DOI för Selection and Evolution of Resistance to Antimicrobial Drugs

Microbiological effects of sublethal levels of antibiotics

Andersson, Dan I.; Hughes, Diarmaid

Ingår i Nature Reviews Microbiology, s. 465-478, 2014

• DOI för Microbiological effects of sublethal levels of antibiotics

Discovery and preclinical development of new antibiotics

Hughes, Diarmaid; Karlén, Anders

Ingår i Upsala Journal of Medical Sciences, s. 162-169, 2014

• DOI för Discovery and preclinical development of new antibiotics

Rifampicin Resistance: Fitness Costs and the Significance of Compensatory Evolution

Hughes, Diarmaid; Brandis, Gerrit

Ingår i Antibiotics, s. 206-216, 2013

• DOI för Rifampicin Resistance: Fitness Costs and the Significance of Compensatory Evolution
• Ladda ner fulltext (pdf) av Rifampicin Resistance: Fitness Costs and the Significance of Compensatory Evolution

The origin of mutants under selection: Interactions of mutation, growth and selection

Andersson, Dan I.; Hughes, Diarmaid; Roth, John R

Ingår i EcoSal Plus, 2011

• DOI för The origin of mutants under selection: Interactions of mutation, growth and selection

Persistence of antibiotic resistance in bacterial populations

Andersson, Dan I.; Hughes, Diarmaid

Ingår i FEMS Microbiology Reviews, s. 901-911, 2011

• DOI för Persistence of antibiotic resistance in bacterial populations

Biological roles of translesion synthesis DNA polymerases in eubacteria

Andersson, Dan I.; Koskiniemi, Sanna; Hughes, Diarmaid

Ingår i Molecular Microbiology, s. 540-548, 2010

• DOI för Biological roles of translesion synthesis DNA polymerases in eubacteria

Antibiotic resistance and its cost: is it possible to reverse resistance?

Andersson, Dan I.; Hughes, Diarmaid

Ingår i Nature Reviews Microbiology, s. 260-271, 2010

• DOI för Antibiotic resistance and its cost: is it possible to reverse resistance?

Gene amplification and adaptive evolution in bacteria

Andersson, Dan I.; Hughes, Diarmaid

Ingår i Annual Review of Genetics, s. 167-195, 2009

• DOI för Gene amplification and adaptive evolution in bacteria

Exploiting genomics, genetics and chemistry to combat antibiotic resistance

Hughes, Diarmaid

Ingår i Nature reviews genetics, s. 432-441, 2003

• DOI för Exploiting genomics, genetics and chemistry to combat antibiotic resistance

The physiological cost of antibiotic resistance

Macvanin, Mirjana; Hughes, Diarmaid

Ingår i Recent research developments in microbiology, s. 607-629, 2003

Evaluating genome dynamics: the constraints on rearrangements within bacterial genomes

Hughes, Diarmaid

Ingår i Genome Biology, s. 6.1-6.8, 2000

• DOI för Evaluating genome dynamics: the constraints on rearrangements within bacterial genomes

Antibiotikaresistens här för att stanna?

Andersson, D.I; Björkman, Johanna; Hughes, Diarmaid

Ingår i Läkartidningen, s. 3940-3944, 1998

tRNA-ribosome interactions

Ehrenberg, Måns; Bilgin, Neş’e; Dincbas, Vildan; Karimi, Reza et al.

Ingår i Biochemistry and Cell Biology, s. 1049-1054, 1995

Ternary complex-ribosome interaction: its influence on protein synthesis and on growth rate

Hughes, Diarmaid; Tubulekas, I

Ingår i Biochemical Society Transactions, s. 851-857, 1993

Antibiotic Development and Resistance

Hughes, Diarmaid; Andersson, Dan I

Taylor and Francis Publishers, London and New York, 2001

Elongation Factors: Translation

Hughes, Diarmaid

Ingår i Reference Module in Life Sciences, Elsevier, 2017

• DOI för Elongation Factors: Translation

Adventures with mutation and selection in beehive and cow country

Hughes, Diarmaid; Andersson, Dan I

Ingår i The Lure of Bacterial Genetics, s. 245-253, ASM Press, 2010

Assays of sensitivity of antibiotic-resistant bacteria to hydrogen peroxide and measurement of catalase activity

Macvanin, Mirjana; Hughes, Diarmaid

Ingår i Antibiotic Resistance Protocols, s. 95-103, Humana Press, 2010

• DOI för Assays of sensitivity of antibiotic-resistant bacteria to hydrogen peroxide and measurement of catalase activity

Measurements of heme levels and respiration rate in Salmonella enterica serovar typhimurium

Hughes, Diarmaid; Macvanin, Mirjana

Ingår i Antibiotic Resistance Protocols, s. 105-112, Humana Press, 2010

• DOI för Measurements of heme levels and respiration rate in Salmonella enterica serovar typhimurium

Effects of antibiotic resistance on bacterial fitness, virulence and transmission

Andersson, Dan I.; Hughes, Diarmaid

Ingår i Evolutionary biology of bacterial and fungal pathogens, s. 307-318, ASM Press, 2008

Comparative genomics and the development of novel antimicrobials

Hughes, Diarmaid

Ingår i Comparative genomics: basic and applied research, s. 177-192, CRC Press, Taylor and Francis Group, Boca Raton, FL, USA, 2008

• DOI för Comparative genomics and the development of novel antimicrobials

Biological consequences for bacteria of homologous recombination

Hughes, Diarmaid; Norström, Tobias

Ingår i The Dynamic Bacterial Genome, s. 351-384, Cambridge University Press, New York, USA, 2005

• DOI för Biological consequences for bacteria of homologous recombination

Target alterations mediating antibiotic resistance

Hughes, Diarmaid; Andersson, Dan I

Ingår i Antibiotic Development and Resistance, s. 23-36, Taylor and Francis Publishers, London and New York, 2001

Impact of homologous recombination and gene conversion on genomic organisation and stability

Hughes, Diarmaid

Ingår i Organization of the prokaryotic genome, s. 109-128, American Society for Microbiology, Washington, USA, 1999

Limitations of translational accuracy

Kurland, CG; Hughes, Diarmaid; Ehrenberg, M.

Ingår i Escherichia coli and Salmonella, s. 979-1004, ASM Press, Washington DC, USA, 1996

Co-evolution protects the tuf genes from inactivation by mobile genetic elements

Brandis, Gerrit; Hughes, Diarmaid

A large chromosomal inversion causes the formation of an unstable tufA/B hybrid operon

Brandis, Gerrit; Hughes, Diarmaid

High-level intrinsic suppression of a frameshift mutation in an essential gene

Huseby, Douglas L.; Praski-Alzrigat, Lisa; Brandis, Gerrit; Hughes, Diarmaid

The evolutionary maintenance of amino acid prototrophy in Escherichia coli

Lindahl, Otto; Berruga Fernández, Talia; Soekhoe, Jivanti; Huseby, Douglas L. et al.

Biological barriers to chromosomal hybrid formation in Escherichia coli

Berruga Fernández, Talia; Henriksson, Sofia; Borowiec, Karolina; Huseby, Douglas L. et al.

Clinical isolates of Klebsiella pneumoniae can transfer chromosomal DNA into Escherichia coli to create novel bacteria with stable hybrid chromosomes

Berruga Fernández, Talia; Kawaguchi, Jun; Huseby, Douglas L.; Hughes, Diarmaid

Antibiotikaresistens: är den reversibel?

Andersson, Dan; Björkman, Johanna; Hughes, Diarmaid

Ingår i Smittskydd: Smittskyddsinstitutets tidskrift, s. 3-5, 1998