Christer Betsholtz

Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis

Kondrychyn, Igor; He, Liqun; Wint, Haymar; Betsholtz, Christer et al.

Ingår i eLIFE, 2025

• DOI för Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis
• Ladda ner fulltext (pdf) av Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis

Distinct strategies for intravascular triglyceride metabolism in hearts of mammals and lower vertebrate species

Nguyen, Le Phuong; Song, Wenxin; Yang, Ye; Tran, Anh P. et al.

Ingår i JCI Insight, 2024

• DOI för Distinct strategies for intravascular triglyceride metabolism in hearts of mammals and lower vertebrate species
• Ladda ner fulltext (pdf) av Distinct strategies for intravascular triglyceride metabolism in hearts of mammals and lower vertebrate species

Mosaic deletion of claudin-5 reveals rapid non-cell-autonomous consequences of blood-brain barrier leakage

Vázquez-Liébanas, Elisa; Mocci, Giuseppe; Li, Weihan; Laviña, Bàrbara et al.

Ingår i Cell Reports, 2024

• DOI för Mosaic deletion of claudin-5 reveals rapid non-cell-autonomous consequences of blood-brain barrier leakage
• Ladda ner fulltext (pdf) av Mosaic deletion of claudin-5 reveals rapid non-cell-autonomous consequences of blood-brain barrier leakage

Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis

Mocci, Giuseppe; Sukhavasi, Katyayani; Ord, Tiit; Bankier, Sean et al.

Ingår i Circulation Research, s. 1405-1423, 2024

• DOI för Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis
• Ladda ner fulltext (pdf) av Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis

Epigenetic modulators link mitochondrial redox homeostasis to cardiac function in a sex-dependent manner

ElBeck, Zaher; Hossain, Mohammad Bakhtiar; Siga, Humam; Oskolkov, Nikolay et al.

Ingår i Nature Communications, 2024

• DOI för Epigenetic modulators link mitochondrial redox homeostasis to cardiac function in a sex-dependent manner
• Ladda ner fulltext (pdf) av Epigenetic modulators link mitochondrial redox homeostasis to cardiac function in a sex-dependent manner

Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis

Kondrychyn, Igor; He, Liqun; Wint, Haymar; Betsholtz, Christer et al.

Ingår i eLIFE, 2025

• DOI för Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis
• Ladda ner fulltext (pdf) av Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis

Distinct strategies for intravascular triglyceride metabolism in hearts of mammals and lower vertebrate species

Nguyen, Le Phuong; Song, Wenxin; Yang, Ye; Tran, Anh P. et al.

Ingår i JCI Insight, 2024

• DOI för Distinct strategies for intravascular triglyceride metabolism in hearts of mammals and lower vertebrate species
• Ladda ner fulltext (pdf) av Distinct strategies for intravascular triglyceride metabolism in hearts of mammals and lower vertebrate species

Mosaic deletion of claudin-5 reveals rapid non-cell-autonomous consequences of blood-brain barrier leakage

Vázquez-Liébanas, Elisa; Mocci, Giuseppe; Li, Weihan; Laviña, Bàrbara et al.

Ingår i Cell Reports, 2024

• DOI för Mosaic deletion of claudin-5 reveals rapid non-cell-autonomous consequences of blood-brain barrier leakage
• Ladda ner fulltext (pdf) av Mosaic deletion of claudin-5 reveals rapid non-cell-autonomous consequences of blood-brain barrier leakage

Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis

Mocci, Giuseppe; Sukhavasi, Katyayani; Ord, Tiit; Bankier, Sean et al.

Ingår i Circulation Research, s. 1405-1423, 2024

• DOI för Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis
• Ladda ner fulltext (pdf) av Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis

Epigenetic modulators link mitochondrial redox homeostasis to cardiac function in a sex-dependent manner

ElBeck, Zaher; Hossain, Mohammad Bakhtiar; Siga, Humam; Oskolkov, Nikolay et al.

Ingår i Nature Communications, 2024

• DOI för Epigenetic modulators link mitochondrial redox homeostasis to cardiac function in a sex-dependent manner
• Ladda ner fulltext (pdf) av Epigenetic modulators link mitochondrial redox homeostasis to cardiac function in a sex-dependent manner

Insights into mechanisms and therapeutic avenues for primary familial brain calcification

Betsholtz, Christer

Ingår i Neuron, s. 3223-3225, 2024

• DOI för Insights into mechanisms and therapeutic avenues for primary familial brain calcification

Distinct strategies for intravascular triglyceride metabolism in hearts of mammals and lower vertebrate species

Nguyen, Le Phuong; Song, Wenxin; Yang, Ye; Tran, Anh P. et al.

Ingår i JCI Insight, 2024

• DOI för Distinct strategies for intravascular triglyceride metabolism in hearts of mammals and lower vertebrate species

Single-cell dissection of the human blood-brain barrier and glioma blood-tumor barrier

Xie, Yuan; Yang, Fan; He, Liqun; Huang, Hua et al.

Ingår i Neuron, 2024

• DOI för Single-cell dissection of the human blood-brain barrier and glioma blood-tumor barrier

Commentary on "Structural characterization of SLYM - a 4th meningeal membrane"

Siegenthaler, Julie; Betsholtz, Christer

Ingår i Fluids and Barriers of the CNS, 2024

• DOI för Commentary on "Structural characterization of SLYM - a 4th meningeal membrane"
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Adipose stem cells are sexually dimorphic cells with dual roles as preadipocytes and resident fibroblasts

Uhrbom, Martin; Muhl, Lars; Genove, Guillem; Liu, Jianping et al.

Ingår i Nature Communications, 2024

• DOI för Adipose stem cells are sexually dimorphic cells with dual roles as preadipocytes and resident fibroblasts
• Ladda ner fulltext (pdf) av Adipose stem cells are sexually dimorphic cells with dual roles as preadipocytes and resident fibroblasts

Rapid and robust isolation of microglia and vascular cells from brain subregions for integrative single-cell analyses

Preka, Efthalia; Romero, Alejandro Lastra; Sun, Ying; Vilalta, Yara Onetti et al.

Ingår i Heliyon, 2024

• DOI för Rapid and robust isolation of microglia and vascular cells from brain subregions for integrative single-cell analyses
• Ladda ner fulltext (pdf) av Rapid and robust isolation of microglia and vascular cells from brain subregions for integrative single-cell analyses

A brain-specific angiogenic mechanism enabled by tip cell specialization

Schevenels, Giel; Cabochette, Pauline; America, Michelle; Vandenborne, Arnaud et al.

Ingår i Nature, s. 863-871, 2024

• DOI för A brain-specific angiogenic mechanism enabled by tip cell specialization
• Ladda ner fulltext (pdf) av A brain-specific angiogenic mechanism enabled by tip cell specialization

Renal Endothelial Single-Cell Transcriptomics Reveals Spatiotemporal Regulation and Divergent Roles of Differential Gene Transcription and Alternative Splicing in Murine Diabetic Nephropathy

Zhou, Alex-Xianghua; Jeansson, Marie; He, Liqun; Wigge, Leif et al.

Ingår i International Journal of Molecular Sciences, 2024

• DOI för Renal Endothelial Single-Cell Transcriptomics Reveals Spatiotemporal Regulation and Divergent Roles of Differential Gene Transcription and Alternative Splicing in Murine Diabetic Nephropathy
• Ladda ner fulltext (pdf) av Renal Endothelial Single-Cell Transcriptomics Reveals Spatiotemporal Regulation and Divergent Roles of Differential Gene Transcription and Alternative Splicing in Murine Diabetic Nephropathy

The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier

Kurtyka, Magdalena; Wessely, Frank; Bau, Sarah; Ifie, Eseoghene et al.

Ingår i European Journal of Cell Biology, 2024

• DOI för The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier
• Ladda ner fulltext (pdf) av The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier

Tumor-specific migration routes of xenotransplanted human glioblastoma cells in mouse brain

Gupta, Rajesh Kumar; Niklasson, Mia; Bergström, Tobias; Segerman, Anna et al.

Ingår i Scientific Reports, 2024

• DOI för Tumor-specific migration routes of xenotransplanted human glioblastoma cells in mouse brain
• Ladda ner fulltext (pdf) av Tumor-specific migration routes of xenotransplanted human glioblastoma cells in mouse brain

A robust and efficient microvascular isolation method for multimodal characterization of the mouse brain vasculature

Bjornholm, Katrine Dahl; Del Gaudio, Francesca; Li, Hao; Li, Weihan et al.

Ingår i CELL REPORTS METHODS, 2023

• DOI för A robust and efficient microvascular isolation method for multimodal characterization of the mouse brain vasculature

The role of dendrin in IgA nephropathy

Levin, Anna; Schwarz, Angelina; Hulkko, Jenny; He, Liqun et al.

Ingår i Nephrology, Dialysis and Transplantation, s. 311-321, 2023

• DOI för The role of dendrin in IgA nephropathy
• Ladda ner fulltext (pdf) av The role of dendrin in IgA nephropathy

Left ventricular hypertrophy and metabolic resetting in the Notch3-deficient adult mouse heart

Del Gaudio, Francesca; Liu, Dongli; Andaloussi Mäe, Maarja; Braune, Eike-Benjamin et al.

Ingår i Scientific Reports, 2023

• DOI för Left ventricular hypertrophy and metabolic resetting in the Notch3-deficient adult mouse heart
• Ladda ner fulltext (pdf) av Left ventricular hypertrophy and metabolic resetting in the Notch3-deficient adult mouse heart

Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation

Petkova, Milena; Kraft, Marle; Stritt, Simon; Martinez-Corral, Ines et al.

Ingår i Journal of Experimental Medicine, 2023

• DOI för Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation
• Ladda ner fulltext (pdf) av Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation

Molecular anatomy of adult mouse leptomeninges

Pietilä, Riikka; Del Gaudio, Francesca; He, Liqun; Vázquez-Liébanas, Elisa et al.

Ingår i Neuron, 2023

• DOI för Molecular anatomy of adult mouse leptomeninges
• Ladda ner fulltext (pdf) av Molecular anatomy of adult mouse leptomeninges

VE-cadherin in arachnoid and pia mater cells serves as a suitable landmark for in vivo imaging of CNS immune surveillance and inflammation

Mapunda, Josephine A.; Pareja, Javier; Vladymyrov, Mykhailo; Bouillet, Elisa et al.

Ingår i Nature Communications, 2023

• DOI för VE-cadherin in arachnoid and pia mater cells serves as a suitable landmark for in vivo imaging of CNS immune surveillance and inflammation
• Ladda ner fulltext (pdf) av VE-cadherin in arachnoid and pia mater cells serves as a suitable landmark for in vivo imaging of CNS immune surveillance and inflammation

Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner

Richards, Mark; Nwadozi, Emmanuel; Pal, Sagnik; Martinsson, Pernilla et al.

Ingår i eLIFE, 2022

• DOI för Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner
• Ladda ner fulltext (pdf) av Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner

Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synovium

Shoda, Jumpei; Tanaka, Shigeru; Etori, Keishi; Hattori, Koto et al.

Ingår i Arthritis Research & Therapy, 2022

• DOI för Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synovium
• Ladda ner fulltext (pdf) av Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synovium

Molecular insights into the early stage of glomerular injury in IgA nephropathy using single-cell RNA sequencing

Zambrano, Sonia; He, Liqun; Kano, Toshiki; Sun, Ying et al.

Ingår i Kidney International, s. 752-765, 2022

• DOI för Molecular insights into the early stage of glomerular injury in IgA nephropathy using single-cell RNA sequencing

Angiopoietin-2 Inhibition of Thrombomodulin-Mediated Anticoagulation: A Novel Mechanism That May Contribute to Hypercoagulation in Critically Ill COVID-19 Patients

Hultström, Michael; Fromell, Karin; Larsson, Anders; Persson, Barbro et al.

Ingår i Biomedicines, 2022

• DOI för Angiopoietin-2 Inhibition of Thrombomodulin-Mediated Anticoagulation: A Novel Mechanism That May Contribute to Hypercoagulation in Critically Ill COVID-19 Patients
• Ladda ner fulltext (pdf) av Angiopoietin-2 Inhibition of Thrombomodulin-Mediated Anticoagulation: A Novel Mechanism That May Contribute to Hypercoagulation in Critically Ill COVID-19 Patients

Cellular Origin of Sporadic CCMs

Betsholtz, Christer; Gängel, Konstantin; Mäkinen, Taija

Ingår i New England Journal of Medicine, s. 1291-1291, 2022

• DOI för Cellular Origin of Sporadic CCMs

A single-cell transcriptomic inventory of murine smooth muscle cells

Muhl, Lars; Mocci, Giuseppe; Pietilä, Riikka; Liu, Jianping et al.

Ingår i Developmental Cell, s. 2426-+, 2022

• DOI för A single-cell transcriptomic inventory of murine smooth muscle cells
• Ladda ner fulltext (pdf) av A single-cell transcriptomic inventory of murine smooth muscle cells

Severe cerebellar malformations in mutant mice demonstrate a role for PDGF-C/PDGFR alpha signalling in cerebellar development

Gillnäs, Sara; Gallini, Radiosa; He, Liqun; Betsholtz, Christer et al.

Ingår i BIOLOGY OPEN, 2022

• DOI för Severe cerebellar malformations in mutant mice demonstrate a role for PDGF-C/PDGFR alpha signalling in cerebellar development
• Ladda ner fulltext (pdf) av Severe cerebellar malformations in mutant mice demonstrate a role for PDGF-C/PDGFR alpha signalling in cerebellar development

Mural Cell SRF Controls Pericyte Migration, Vessel Patterning and Blood Flow

Orlich, Michael M.; Dieguez-Hurtado, Rodrigo; Muehlfriedel, Regine; Sothilingam, Vithiyanjali et al.

Ingår i Circulation Research, s. 308-327, 2022

• DOI för Mural Cell SRF Controls Pericyte Migration, Vessel Patterning and Blood Flow
• Ladda ner fulltext (pdf) av Mural Cell SRF Controls Pericyte Migration, Vessel Patterning and Blood Flow

PDGFR beta(+) cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny

da Bandeira, Diana Sa; Kilpatrick, Alastair Morris; Marques, Madalena; Gomez-Salazar, Mario et al.

Ingår i Cell Reports, 2022

• DOI för PDGFR beta(+) cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny
• Ladda ner fulltext (pdf) av PDGFR beta(+) cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny

Adult-induced genetic ablation distinguishes PDGFB roles in blood-brain barrier maintenance and development

Vazquez-Liebanas, Elisa; Nahar, Khayrun; Bertuzzi, Giacomo; Keller, Annika et al.

Ingår i Journal of Cerebral Blood Flow and Metabolism, s. 264-279, 2022

• DOI för Adult-induced genetic ablation distinguishes PDGFB roles in blood-brain barrier maintenance and development
• Ladda ner fulltext (pdf) av Adult-induced genetic ablation distinguishes PDGFB roles in blood-brain barrier maintenance and development

An overlooked subset of Cx3cr1(wt/wt) microglia in the Cx3cr1(CreER-Eyfp/wt) mouse has a repopulation advantage over Cx3cr1(CreER-Eyfp/wt) microglia following microglial depletion

Zhou, Kai; Han, Jinming; Lund, Harald; Boggavarapu, Nageswara Rao et al.

Ingår i Journal of Neuroinflammation, 2022

• DOI för An overlooked subset of Cx3cr1(wt/wt) microglia in the Cx3cr1(CreER-Eyfp/wt) mouse has a repopulation advantage over Cx3cr1(CreER-Eyfp/wt) microglia following microglial depletion
• Ladda ner fulltext (pdf) av An overlooked subset of Cx3cr1(wt/wt) microglia in the Cx3cr1(CreER-Eyfp/wt) mouse has a repopulation advantage over Cx3cr1(CreER-Eyfp/wt) microglia following microglial depletion

Proper migration of lymphatic endothelial cells requires survival and guidance cues from arterial mural cells

Peng, Di; Ando, Koji; Hussmann, Melina; Gloger, Marleen et al.

Ingår i eLIFE, 2022

• DOI för Proper migration of lymphatic endothelial cells requires survival and guidance cues from arterial mural cells
• Ladda ner fulltext (pdf) av Proper migration of lymphatic endothelial cells requires survival and guidance cues from arterial mural cells

Microvascular stabilization via blood-brain barrier regulation prevents seizure activity

Greene, Chris; Hanley, Nicole; Reschke, Cristina R.; Reddy, Avril et al.

Ingår i Nature Communications, 2022

• DOI för Microvascular stabilization via blood-brain barrier regulation prevents seizure activity
• Ladda ner fulltext (pdf) av Microvascular stabilization via blood-brain barrier regulation prevents seizure activity

The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research

Muhl, Lars; He, Liqun; Sun, Ying; Andaloussi Mäe, Maarja et al.

Ingår i Stem Cell Reports, s. 1089-1104, 2022

• DOI för The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research

ADAMTS18⁺ villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing intestinal blood vessels

Bernier-Latmani, Jeremiah; Mauri, Cristina; Marcone, Rachel; Renevey, Francois et al.

Ingår i Nature Communications, 2022

• DOI för ADAMTS18⁺ villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing intestinal blood vessels
• Ladda ner fulltext (pdf) av ADAMTS18⁺ villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing intestinal blood vessels

Specification of CNS macrophage subsets occurs postnatally in defined niches

Masuda, Takahiro; Amann, Lukas; Monaco, Gianni; Sankowski, Roman et al.

Ingår i Nature, s. 740-+, 2022

• DOI för Specification of CNS macrophage subsets occurs postnatally in defined niches

KCNJ8/ABCC9-containing K-ATP channel modulates brain vascular smooth muscle development and neurovascular coupling

Ando, Koji; Tong, Lei; Peng, Di; Vazquez-Liebanas, Elisa et al.

Ingår i Developmental Cell, s. 1383-13990000000, 2022

• DOI för KCNJ8/ABCC9-containing K-ATP channel modulates brain vascular smooth muscle development and neurovascular coupling

Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes

He, Bing; Chen, Ping; Zambrano, Sonia; Dabaghie, Dina et al.

Ingår i Nature Communications, 2021

• DOI för Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes
• Ladda ner fulltext (pdf) av Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes

VEGF-B Promotes Endocardium-Derived Coronary Vessel Development and Cardiac Regeneration

Räsänen, Markus; Sultan, Ibrahim; Paech, Jennifer; Hemanthakumar, Karthik Amudhala et al.

Ingår i Circulation, s. 65-77, 2021

• DOI för VEGF-B Promotes Endocardium-Derived Coronary Vessel Development and Cardiac Regeneration
• Ladda ner fulltext (pdf) av VEGF-B Promotes Endocardium-Derived Coronary Vessel Development and Cardiac Regeneration

Lack of Evidence of Angiotensin-Converting Enzyme 2 Expression and Replicative Infection by SARS-CoV-2 in Human Endothelial Cells

McCracken, Ian R.; Saginc, Gaye; He, Liqun; Huseynov, Alik et al.

Ingår i Circulation, s. 865-868, 2021

• DOI för Lack of Evidence of Angiotensin-Converting Enzyme 2 Expression and Replicative Infection by SARS-CoV-2 in Human Endothelial Cells

Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing

Xie, Yuan; He, Liqun; Lugano, Roberta; Zhang, Yanyu et al.

Ingår i JCI Insight, 2021

• DOI för Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing
• Ladda ner fulltext (pdf) av Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing

ELTD1-deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma.

Huang, Hua; Georganaki, Maria; Conze, Lei Liu; Laviña, Bàrbara et al.

Ingår i Neuro-Oncology, s. 398-411, 2021

• DOI för ELTD1-deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma.
• Ladda ner fulltext (pdf) av ELTD1-deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma.

Vascular PDGFR-alpha protects against BBB dysfunction after stroke in mice

Nguyen, Quang Linh; Okuno, Noriko; Hamashima, Takeru; Dang, Son Tung et al.

Ingår i Angiogenesis, s. 35-46, 2021

• DOI för Vascular PDGFR-alpha protects against BBB dysfunction after stroke in mice

A human cell type similar to murine central nervous system perivascular fibroblasts

Liu, Jianping; He, Liqun; Muhl, Lars; Mocci, Giuseppe et al.

Ingår i Experimental Cell Research, 2021

• DOI för A human cell type similar to murine central nervous system perivascular fibroblasts
• Ladda ner fulltext (pdf) av A human cell type similar to murine central nervous system perivascular fibroblasts

Conserved and context-dependent roles for pdgfrb signaling during zebrafish vascular mural cell development

Ando, Koji; Shih, Yu-Huan; Ebarasi, Lwaki; Grosse, Ann et al.

Ingår i Developmental Biology, s. 11-22, 2021

• DOI för Conserved and context-dependent roles for pdgfrb signaling during zebrafish vascular mural cell development

A Switch from Cell-Associated to Soluble PDGF-B Protects against Atherosclerosis, despite Driving Extramedullary Hematopoiesis

Tillie, Renee J. H. A.; Theelen, Thomas L.; van Kuijk, Kim; Temmerman, Lieve et al.

Ingår i Cells, s. 1746, 2021

• DOI för A Switch from Cell-Associated to Soluble PDGF-B Protects against Atherosclerosis, despite Driving Extramedullary Hematopoiesis
• Ladda ner fulltext (pdf) av A Switch from Cell-Associated to Soluble PDGF-B Protects against Atherosclerosis, despite Driving Extramedullary Hematopoiesis

Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss

Mäe, Maarja Andaloussi; He, Liqun; Nordling, Sofia; Vazquez-Liebanas, Elisa et al.

Ingår i Circulation Research, 2021

• DOI för Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss

Elevated Angiopoietin-2 inhibits thrombomodulin-mediated anticoagulation in critically ill COVID-19 patients

Hultström, Michael; Fromell, Karin; Larsson, Anders; Quaggin, Susan E et al.

Ingår i medRxiv, s. 1-27, 2021

• DOI för Elevated Angiopoietin-2 inhibits thrombomodulin-mediated anticoagulation in critically ill COVID-19 patients

A novel podocyte protein, R3h domain containing-like, inhibits TGF-β-induced p38 MAPK and regulates the structure of podocytes and glomerular basement membrane

Ishikawa, Takahiro; Takemoto, Minoru; Akimoto, Yoshihiro; Takada-Watanabe, Aki et al.

Ingår i Journal of Molecular Medicine, s. 859-876, 2021

• DOI för A novel podocyte protein, R3h domain containing-like, inhibits TGF-β-induced p38 MAPK and regulates the structure of podocytes and glomerular basement membrane

The infantile myofibromatosis NOTCH3 L1519P mutation leads to hyperactivated ligand-independent Notch signaling and increased PDGFRB expression

Wu, Dan; Wang, Sailan; Oliveira, Daniel V.; Del Gaudio, Francesca et al.

Ingår i Disease Models and Mechanisms, 2021

• DOI för The infantile myofibromatosis NOTCH3 L1519P mutation leads to hyperactivated ligand-independent Notch signaling and increased PDGFRB expression
• Ladda ner fulltext (pdf) av The infantile myofibromatosis NOTCH3 L1519P mutation leads to hyperactivated ligand-independent Notch signaling and increased PDGFRB expression

Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier

Santander, Nicolas; Lizama, Carlos O.; Meky, Eman; McKinsey, Gabriel L. et al.

Ingår i Journal of Clinical Investigation, s. 4055-4068, 2020

• DOI för Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier

Radiation Triggers a Dynamic Sequence of Transient Microglial Alterations in Juvenile Brain

Osman, Ahmed M.; Sun, Ying; Burns, Terry C.; He, Liqun et al.

Ingår i Cell Reports, 2020

• DOI för Radiation Triggers a Dynamic Sequence of Transient Microglial Alterations in Juvenile Brain
• Ladda ner fulltext (pdf) av Radiation Triggers a Dynamic Sequence of Transient Microglial Alterations in Juvenile Brain

Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis

Wang, Guangxia; Muhl, Lars; Padberg, Yvonne; Dupont, Laura et al.

Ingår i Nature Communications, 2020

• DOI för Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis
• Ladda ner fulltext (pdf) av Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis

Tamoxifen-independent recombination of reporter genes limits lineage tracing and mosaic analysis using CreER(T2) lines

Alvarez, Alberto; Martinez-Corral, Ines; Daubel, Nina; Betsholtz, Christer et al.

Ingår i Transgenic research, s. 53-68, 2020

• DOI för Tamoxifen-independent recombination of reporter genes limits lineage tracing and mosaic analysis using CreER(T2) lines
• Ladda ner fulltext (pdf) av Tamoxifen-independent recombination of reporter genes limits lineage tracing and mosaic analysis using CreER(T2) lines

Pericyte dysfunction due to Shb gene deficiency increases B16F10 melanoma lung metastasis

He, Qi; Li, Xiujuan; He, Liqun; Li, Yousheng et al.

Ingår i International Journal of Cancer, s. 2634-2644, 2020

• DOI för Pericyte dysfunction due to Shb gene deficiency increases B16F10 melanoma lung metastasis
• Ladda ner fulltext (pdf) av Pericyte dysfunction due to Shb gene deficiency increases B16F10 melanoma lung metastasis

Astrocyte-microglial association and matrix composition are common events in the natural history of primary familial brain calcification

Nahar, Khayrun; Lebouvier, Thibaud; Andaloussi Mäe, Maarja; Konzer, Anne et al.

Ingår i Brain Pathology, s. 446-464, 2020

• DOI för Astrocyte-microglial association and matrix composition are common events in the natural history of primary familial brain calcification
• Ladda ner fulltext (pdf) av Astrocyte-microglial association and matrix composition are common events in the natural history of primary familial brain calcification

Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis

Zhang, Yanyu; Cedervall, Jessica; Hamidi, Anahita; Herre, Melanie et al.

Ingår i Cancer Research, s. 3345-3358, 2020

• DOI för Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis

Lung developmental arrest caused by PDGF-A deletion: consequences for the adult mouse lung

Gouveia, Maria Leonor Seguardo; Kraut, Simone; Hadzic, Stefan; Vazquez-Liebanas, Elisa et al.

Ingår i American Journal of Physiology - Lung cellular and Molecular Physiology, 2020

• DOI för Lung developmental arrest caused by PDGF-A deletion: consequences for the adult mouse lung

Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization

Yanagida, Keisuke; Engelbrecht, Eric; Niaudet, Colin; Jung, Bongnam et al.

Ingår i Developmental Cell, s. 779-+, 2020

• DOI för Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization

Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta

Engelbrecht, Eric; Levesque, Michel; He, Liqun; Vanlandewijck, Michael et al.

Ingår i eLIFE, 2020

• DOI för Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta
• Ladda ner fulltext (pdf) av Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta

Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits

Glicksberg, Benjamin S.; Amadori, Letizia; Akers, Nicholas K.; Sukhavasi, Katyayani et al.

Ingår i BMC Medical Genomics, 2019

• DOI för Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits
• Ladda ner fulltext (pdf) av Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits

PDGF-B Is Required for Development of the Glymphatic System

Munk, Anne Sofie; Wang, Wei; Bechet, Nicholas Burdon; Eltanahy, Ahmed M. et al.

Ingår i Cell Reports, s. 2955-+, 2019

• DOI för PDGF-B Is Required for Development of the Glymphatic System
• Ladda ner fulltext (pdf) av PDGF-B Is Required for Development of the Glymphatic System

Powerful Homeostatic Control of Oligodendroglial Lineage by PDGFR alpha in Adult Brain

Dang, Thanh Chung; Ishii, Yoko; Nguyen, Van De; Yamamoto, Seiji et al.

Ingår i Cell Reports, s. 1073-1089, 2019

• DOI för Powerful Homeostatic Control of Oligodendroglial Lineage by PDGFR alpha in Adult Brain
• Ladda ner fulltext (pdf) av Powerful Homeostatic Control of Oligodendroglial Lineage by PDGFR alpha in Adult Brain

Peri-arterial specification of vascular mural cells from naive mesenchyme requires Notch signaling

Ando, Koji; Wang, Weili; Peng, Di; Chiba, Ayano et al.

Ingår i Development, 2019

• DOI för Peri-arterial specification of vascular mural cells from naive mesenchyme requires Notch signaling

Claudin-3-deficient C57BL/6J mice display intact brain barriers

Dias, Mariana Castro; Coisne, Caroline; Lazarevic, Ivana; Baden, Pascale et al.

Ingår i Scientific Reports, 2019

• DOI för Claudin-3-deficient C57BL/6J mice display intact brain barriers
• Ladda ner fulltext (pdf) av Claudin-3-deficient C57BL/6J mice display intact brain barriers

Adgrf5 contributes to patterning of the endothelial deep layer in retina

Niaudet, Colin; Petkova, Milena; Jung, Bongnam; Lu, S. et al.

Ingår i Angiogenesis, s. 491-505, 2019

• DOI för Adgrf5 contributes to patterning of the endothelial deep layer in retina
• Ladda ner fulltext (pdf) av Adgrf5 contributes to patterning of the endothelial deep layer in retina

R3hdml regulates satellite cell proliferation and differentiation

Sakamoto, Kenichi; Furuichi, Yasuro; Yamamoto, Masashi; Takahashi, Megumi et al.

Ingår i EMBO Reports, 2019

• DOI för R3hdml regulates satellite cell proliferation and differentiation

GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients

Hu, Xuchen; Matsumoto, Ken; Jung, Rachel S.; Weston, Thomas A. et al.

Ingår i eLIFE, 2019

• DOI för GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients
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CDC42 deletion elicits cerebral vascular malformations via increased MEKK3-dependent KLF4 expression

Castro, Marco; Laviña, Bàrbara; Ando, Koji; Alvarez-Aznar, Alberto et al.

Ingår i Circulation Research, s. 1240-1252, 2019

• DOI för CDC42 deletion elicits cerebral vascular malformations via increased MEKK3-dependent KLF4 expression

Sprouting and anastomosis in the Drosophila trachea and the vertebrate vasculature: Similarities and differences in cell behaviour

Kotini, Maria Paraskevi; Mäe, Maarja Andaloussi; Belting, Heinz-Georg; Betsholtz, Christer et al.

Ingår i Vascular pharmacology, s. 8-16, 2019

• DOI för Sprouting and anastomosis in the Drosophila trachea and the vertebrate vasculature: Similarities and differences in cell behaviour

Inverse correlation between vascular endothelial growth factor back-filtration and capillary filtration pressures

Kuppe, Christoph; Rohlfs, Wilko; Grepl, Martin; Schulte, Kevin et al.

Ingår i Nephrology, Dialysis and Transplantation, s. 1514-1525, 2018

• DOI för Inverse correlation between vascular endothelial growth factor back-filtration and capillary filtration pressures

Global analysis of A-to-I RNA editing reveals association with common disease variants

Franzen, Oscar; Ermel, Raili; Sukhavasi, Katyayani; Jain, Rajeev et al.

Ingår i PeerJ, 2018

• DOI för Global analysis of A-to-I RNA editing reveals association with common disease variants
• Ladda ner fulltext (pdf) av Global analysis of A-to-I RNA editing reveals association with common disease variants

Intravital imaging-based analysis tools for vessel identification and assessment of concurrent dynamic vascular events

Honkura, Naoki; Richards, Mark; Laviña, Bàrbara; Sainz-Jaspeado, Miguel et al.

Ingår i Nature Communications, 2018

• DOI för Intravital imaging-based analysis tools for vessel identification and assessment of concurrent dynamic vascular events
• Ladda ner fulltext (pdf) av Intravital imaging-based analysis tools for vessel identification and assessment of concurrent dynamic vascular events

Prolonged systemic hyperglycemia does not cause pericyte loss and permeability at the mouse blood-brain barrier

Mäe, Maarja Andaloussi; Li, Tian; Bertuzzi, Giacomo; Raschperger, Elisabeth et al.

Ingår i Scientific Reports, 2018

• DOI för Prolonged systemic hyperglycemia does not cause pericyte loss and permeability at the mouse blood-brain barrier
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Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations

Laviña, Bàrbara; Castro, Marco; Niaudet, Colin; Cruys, Bert et al.

Ingår i Development, 2018

• DOI för Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations

Angiopoietin-1 deficiency increases renal capillary rarefaction and tubulointerstitial fibrosis in mice

Loganathan, Krishnapriya; Salem Said, Ebtisam; Winterrowd, Emily; Orebrand, Martina et al.

Ingår i PLOS ONE, 2018

• DOI för Angiopoietin-1 deficiency increases renal capillary rarefaction and tubulointerstitial fibrosis in mice
• Ladda ner fulltext (pdf) av Angiopoietin-1 deficiency increases renal capillary rarefaction and tubulointerstitial fibrosis in mice

A molecular atlas of cell types and zonation in the brain vasculature

Vanlandewijck, Michael; He, Liqun; Mäe, Maarja Andaloussi; Andrae, Johanna et al.

Ingår i Nature, s. 475-480, 2018

• DOI för A molecular atlas of cell types and zonation in the brain vasculature

Rate of Small-Molecular Drug Transport Across the Blood-Brain Barrier in a Pericyte-Deficient State

Mihajlica, Nebojsa; Betsholtz, Christer; Hammarlund-Udenaes, Margareta

Ingår i European Journal of Pharmaceutical Sciences, s. 182-187, 2018

• DOI för Rate of Small-Molecular Drug Transport Across the Blood-Brain Barrier in a Pericyte-Deficient State

Multiple roles of lymphatic vessels in peripheral lymph node development

Bovay, Esther; Sabine, Amelie; Prat-Luri, Borja; Kim, Sudong et al.

Ingår i Journal of Experimental Medicine, s. 2760-2777, 2018

• DOI för Multiple roles of lymphatic vessels in peripheral lymph node development

Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types

He, Liqun; Vanlandewijck, Michael; Mäe, Maarja Andaloussi; Andrae, Johanna et al.

Ingår i Scientific Data, 2018

• DOI för Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types
• Ladda ner fulltext (pdf) av Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types

Pharmacokinetics of Pericyte Involvement in Small-Molecular Drug Transport Across the Blood-Brain Barrier

Mihajlica, Nebojsa; Betsholtz, Christer; Hammarlund-Udenaes, Margareta

Ingår i European Journal of Pharmaceutical Sciences, s. 77-84, 2018

• DOI för Pharmacokinetics of Pericyte Involvement in Small-Molecular Drug Transport Across the Blood-Brain Barrier

PDGF-A signaling is required for secondary alveolar septation and controls epithelial proliferation in the developing lung

Gouveia, Leonor; Betsholtz, Christer; Andrae, Johanna

Ingår i Development, 2018

• DOI för PDGF-A signaling is required for secondary alveolar septation and controls epithelial proliferation in the developing lung

Visualization of vascular mural cells in developing brain using genetically labeled transgenic reporter mice

Jung, Bongnam; Arnold, Thomas D.; Raschperger, Elisabeth; Gaengel, Konstantin et al.

Ingår i Journal of Cerebral Blood Flow and Metabolism, s. 456-468, 2018

• DOI för Visualization of vascular mural cells in developing brain using genetically labeled transgenic reporter mice
• Ladda ner fulltext (pdf) av Visualization of vascular mural cells in developing brain using genetically labeled transgenic reporter mice

Cell-cell signaling in blood vessel development and function

Betsholtz, Christer

Ingår i EMBO Molecular Medicine, 2018

• DOI för Cell-cell signaling in blood vessel development and function
• Ladda ner fulltext (pdf) av Cell-cell signaling in blood vessel development and function

Extracellular retention of PDGF-B directs vascular remodeling in mouse hypoxia-induced pulmonary hypertension

Tannenberg, Philip; Chang, Ya-Ting; Muhl, Lars; Laviña, Bàrbara et al.

Ingår i American Journal of Physiology - Lung cellular and Molecular Physiology, s. 1593-1605, 2018

• DOI för Extracellular retention of PDGF-B directs vascular remodeling in mouse hypoxia-induced pulmonary hypertension

Transcriptomic and Proteomic Profiling Provides Insight into Mesangial Cell Function in IgA Nephropathy

Liu, Peidi; Lassen, Emelie; Nair, Viji; Berthier, Celine C. et al.

Ingår i Journal of the American Society of Nephrology, s. 2961-2972, 2017

• DOI för Transcriptomic and Proteomic Profiling Provides Insight into Mesangial Cell Function in IgA Nephropathy

Claudin 3-Deficient C57BL/6 Mice Display Intact Brain Barriers

Dias, Mariana; Coisne, Caroline; Baden, Pascale; Lazarevic, Ivana et al.

Ingår i Journal of Vascular Research, s. 63-63, 2017

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci

Jones, Gregory T.; Tromp, Gerard; Kuivaniemi, Helena; Gretarsdottir, Solveig et al.

Ingår i Circulation Research, s. 341-+, 2017

• DOI för Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci
• Ladda ner fulltext (pdf) av Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci

Expression analysis of platelet-derived growth factor receptor alpha and its ligands in the developing mouse lung

Gouveia, Leonor; Betsholtz, Christer; Andrae, Johanna

Ingår i Physiological Reports, 2017

• DOI för Expression analysis of platelet-derived growth factor receptor alpha and its ligands in the developing mouse lung
• Ladda ner fulltext (pdf) av Expression analysis of platelet-derived growth factor receptor alpha and its ligands in the developing mouse lung

Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination

De La Fuente, Alerie Guzman; Lange, Simona; Silva, Maria Elena; Gonzalez, Ginez A. et al.

Ingår i Cell Reports, s. 1755-1764, 2017

• DOI för Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination

Pericytes promote the generation of oligodendrocytes during remyelination

Guzman, A.; Lange, S.; Silva, M. E.; Gonzalez, G. A. et al.

Ingår i Glia, 2017

• DOI för Pericytes promote the generation of oligodendrocytes during remyelination

Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling

Jin, Yi; Muhl, Lars; Burmakin, Mikhail; Wang, Yixin et al.

Ingår i Nature Cell Biology, s. 639-652, 2017

• DOI för Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling

Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity

Wang, Yixin; Jin, Yi; Mäe, Maarja Andaloussi; Zhang, Yang et al.

Ingår i Development, s. 3590-3601, 2017

• DOI för Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity

PDGFR alpha signaling is required for alveolar development in the mouse lung

Andrae, Johanna; Betsholtz, Christer; Gouveia, Maria Leonor Seguardo

Ingår i Mechanisms of Development, 2017

• DOI för PDGFR alpha signaling is required for alveolar development in the mouse lung

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease

Webb, Thomas R.; Erdmann, Jeanette; Stirrups, Kathleen E.; Stitziel, Nathan O. et al.

Ingår i Journal of the American College of Cardiology, s. 823-836, 2017

• DOI för Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease
• Ladda ner fulltext (pdf) av Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease

The role of microglia in microvascular calcification in the brain

Keller, A.; Zarb, Y.; Johannson, B.; Betsholtz, Christer et al.

Ingår i Glia, 2017

• DOI för The role of microglia in microvascular calcification in the brain

Mice Lacking Platelet-Derived Growth Factor D Display a Mild Vascular Phenotype

Gladh, Hanna; Folestad, Erika Bergsten; Muhl, Lars; Ehnman, Monika et al.

Ingår i PLOS ONE, 2016

• DOI för Mice Lacking Platelet-Derived Growth Factor D Display a Mild Vascular Phenotype
• Ladda ner fulltext (pdf) av Mice Lacking Platelet-Derived Growth Factor D Display a Mild Vascular Phenotype

Analysis of the brain mural cell transcriptome

He, Liqun; Vanlandewijck, Michael; Raschperger, Elisabeth; Mae, Maarja Andaloussi et al.

Ingår i Scientific Reports, 2016

• DOI för Analysis of the brain mural cell transcriptome
• Ladda ner fulltext (pdf) av Analysis of the brain mural cell transcriptome

Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci

Miller, Clint L.; Pjanic, Milos; Wang, Ting; Nguyen, Trieu et al.

Ingår i Nature Communications, 2016

• DOI för Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci
• Ladda ner fulltext (pdf) av Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci

Transcriptional control of endothelial energy

Betsholtz, Christer

Ingår i Nature, s. 160-161, 2016

• DOI för Transcriptional control of endothelial energy

VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread

Li, Xiujuan; Padhan, Narendra; Sjöström, Elisabet O.; Roche, Francis P. et al.

Ingår i Nature Communications, 2016

• DOI för VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread
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A novel podocyte gene, semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation

Ishibashi, Ryoichi; Takemoto, Minoru; Akimoto, Yoshihiro; Ishikawa, Takahiro et al.

Ingår i Scientific Reports, 2016

• DOI för A novel podocyte gene, semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation
• Ladda ner fulltext (pdf) av A novel podocyte gene, semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation

Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier

Villasenor, Roberto; Ozmen, Laurence; Messaddeq, Nadia; Gruninger, Fiona et al.

Ingår i Scientific Reports, 2016

• DOI för Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier
• Ladda ner fulltext (pdf) av Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier

Oligodendrocytes follow blood vessel trails in the brain Brain microvasculature is a scaffold for neuroglial migration

Dejana, Elisabetta; Betsholtz, Christer

Ingår i Science, s. 341-342, 2016

• DOI för Oligodendrocytes follow blood vessel trails in the brain Brain microvasculature is a scaffold for neuroglial migration

Isoform-Specific Modulation of Inflammation Induced by Adenoviral Mediated Delivery of Platelet-Derived Growth Factors in the Adult Mouse Heart

Gallini, Radiosa; Huusko, Jenni; Yla-Herttuala, Seppo; Betsholtz, Christer et al.

Ingår i PLOS ONE, 2016

• DOI för Isoform-Specific Modulation of Inflammation Induced by Adenoviral Mediated Delivery of Platelet-Derived Growth Factors in the Adult Mouse Heart
• Ladda ner fulltext (pdf) av Isoform-Specific Modulation of Inflammation Induced by Adenoviral Mediated Delivery of Platelet-Derived Growth Factors in the Adult Mouse Heart

Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis

Rivera-Gonzalez, Guillermo C.; Shook, Brett A.; Andrae, Johanna; Holtrup, Brandon et al.

Ingår i Cell Stem Cell, s. 738-751, 2016

• DOI för Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis

PDGF-A and PDGF-B induces cardiac fibrosis in transgenic mice

Gallini, Radiosa; Lindblom, Per; Bondjers, Cecilia; Betsholtz, Christer et al.

Ingår i Experimental Cell Research, s. 282-290, 2016

• DOI för PDGF-A and PDGF-B induces cardiac fibrosis in transgenic mice
• Ladda ner fulltext (pdf) av PDGF-A and PDGF-B induces cardiac fibrosis in transgenic mice

A role for PDGF-C/PDGFR alpha signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex

Andrae, Johanna; Gouveia, Leonor; Gallini, Radiosa; He, Liqun et al.

Ingår i BIOLOGY OPEN, s. 461-474, 2016

• DOI för A role for PDGF-C/PDGFR alpha signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex
• Ladda ner fulltext (pdf) av A role for PDGF-C/PDGFR alpha signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex

Lack Of Pdgf-B Retention Ameliorates Hypoxia-Induced Pulmonary Hypertension

Tannenberg, P.; Folestad, E.; Chang, Y. -T; Gladh, H. et al.

Ingår i American Journal of Respiratory and Critical Care Medicine, 2016

An Endothelial Gene Signature Score Predicts Poor Outcome in Patients with Endocrine-Treated, Low Genomic Grade Breast Tumors

Tobin, Nicholas P.; Wennmalm, Kristian; Lindstrom, Linda S.; Foukakis, Theodoros et al.

Ingår i Clinical Cancer Research, s. 2417-2426, 2016

• DOI för An Endothelial Gene Signature Score Predicts Poor Outcome in Patients with Endocrine-Treated, Low Genomic Grade Breast Tumors

Age-dependent modulation of vascular niches for haematopoietic stem cells

Kusumbe, Anjali P.; Ramasamy, Saravana K.; Itkin, Tomer; Mae, Maarja Andaloussi et al.

Ingår i Nature, s. 380-+, 2016

• DOI för Age-dependent modulation of vascular niches for haematopoietic stem cells

Knockdown of Tmem234 in zebrafish results in proteinuria

Rodriguez, Patricia Q.; Oddsson, Asmundur; Ebarasi, Lwaki; He, Bing et al.

Ingår i AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2015

• DOI för Knockdown of Tmem234 in zebrafish results in proteinuria

Gpr116 Receptor Regulates Distinctive Functions in Pneumocytes and Vascular Endothelium

Niaudet, Colin; Hofmann, Jennifer J.; Mae, Maarja A.; Jung, Bongnam et al.

Ingår i PLOS ONE, 2015

• DOI för Gpr116 Receptor Regulates Distinctive Functions in Pneumocytes and Vascular Endothelium

Lipid transport and human brain development

Betsholtz, Christer

Ingår i Nature Genetics, s. 699-701, 2015

• DOI för Lipid transport and human brain development

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

Zeisel, Amit; Munoz-Manchado, Ana B.; Codeluppi, Simone; Lonnerberg, Peter et al.

Ingår i Science, s. 1138-1142, 2015

• DOI för Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

Notch3 Is Necessary for Blood Vessel Integrity in the Central Nervous System

Henshall, Tanya L; Keller, Annika; He, Liqun; Johansson, Bengt R et al.

Ingår i Arteriosclerosis, Thrombosis and Vascular Biology, s. 409-420, 2015

• DOI för Notch3 Is Necessary for Blood Vessel Integrity in the Central Nervous System

cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels

Stanczuk, Lukas; Martinez-Corral, Ines; Ulvmar, Maria H.; Zhang, Yang et al.

Ingår i Cell Reports, s. 1708-1721, 2015

• DOI för cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels
• Ladda ner fulltext (pdf) av cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels

Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification

Vanlandewijck, Michael; Lebouvier, Thibaud; Mae, Maarja Andaloussi; Nahar, Khayrun et al.

Ingår i PLOS ONE, 2015

• DOI för Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification
• Ladda ner fulltext (pdf) av Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification

Establishment and Dysfunction of the Blood-Brain Barrier

Zhao, Zhen; Nelson, Amy R.; Betsholtz, Christer; Zlokovic, Berislav V.

Ingår i Cell, s. 1064-1078, 2015

• DOI för Establishment and Dysfunction of the Blood-Brain Barrier

Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish

Kok, Fatma O.; Shin, Masahiro; Ni, Chih-Wen; Gupta, Ankit et al.

Ingår i Developmental Cell, s. 97-108, 2015

• DOI för Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish

Lmx1b and FoxC Combinatorially Regulate Podocin Expression in Podocytes

He, Bing; Ebarasi, Lwaki; Zhao, Zhe; Guo, Jing et al.

Ingår i Journal of the American Society of Nephrology, s. 2764-2777, 2014

• DOI för Lmx1b and FoxC Combinatorially Regulate Podocin Expression in Podocytes

A novel podocyte gene, R3h domain containing-like inhibits non-canonical TGF-beta signalling

Ishikawa, T.; Takemoto, M.; Akimoto, Y.; Yan, K. et al.

Ingår i Diabetologia, 2014

PDGF, Pericytes and the Pathogenesis of Idiopathic Basal Ganglia Calcification (IBGC)

Betsholtz, Christer; Keller, Annika

Ingår i Brain Pathology, s. 387-395, 2014

• DOI för PDGF, Pericytes and the Pathogenesis of Idiopathic Basal Ganglia Calcification (IBGC)

Double function at the blood-brain barrier

Betsholtz, Christer

Ingår i Nature, s. 432-433, 2014

• DOI för Double function at the blood-brain barrier

Wtip- and Gadd45a-Interacting Protein Dendrin Is Not Crucial for the Development or Maintenance of the Glomerular Filtration Barrier

Xiao, Zhijie; Rodriguez, Patricia Q.; He, Liqun; Betsholtz, Christer et al.

Ingår i PLOS ONE, 2013

• DOI för Wtip- and Gadd45a-Interacting Protein Dendrin Is Not Crucial for the Development or Maintenance of the Glomerular Filtration Barrier
• Ladda ner fulltext (pdf) av Wtip- and Gadd45a-Interacting Protein Dendrin Is Not Crucial for the Development or Maintenance of the Glomerular Filtration Barrier

Analysis of Mice Lacking the Heparin-Binding Splice Isoform of Platelet-Derived Growth Factor A

Andrae, Johanna; Ehrencrona, Hans; Gallini, Radiosa; Lal, Mark et al.

Ingår i Molecular and Cellular Biology, s. 4030-4040, 2013

• DOI för Analysis of Mice Lacking the Heparin-Binding Splice Isoform of Platelet-Derived Growth Factor A

Targeting of alpha(v) integrin identifies a core molecular pathway that regulates fibrosis in several organs

Henderson, Neil C.; Arnold, Thomas D.; Katamura, Yoshio; Giacomini, Marilyn M. et al.

Ingår i Nature Medicine, s. 1617-1624, 2013

• DOI för Targeting of alpha(v) integrin identifies a core molecular pathway that regulates fibrosis in several organs

Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice

Keller, Annika; Westenberger, Ana; Sobrido, Maria J.; Garcia-Murias, Maria et al.

Ingår i Nature Genetics, s. 1077-+, 2013

• DOI för Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice

Endocytosis regulates VEGF signalling during angiogenesis

Gängel, Konstantin; Betsholtz, Christer

Ingår i Nature Cell Biology, s. 233-235, 2013

• DOI för Endocytosis regulates VEGF signalling during angiogenesis

Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate

Furuhashi, Masao; Sjöblom, Tobias; Abramsson, Alexandra; Ellingsen, Jens et al.

Ingår i Cancer Research, s. 2725-2733, 2004

• DOI för Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate

Advances and controversies in meningeal biology

Betsholtz, Christer; Engelhardt, Britta; Koh, Gou Young; Mcdonald, Donald M. et al.

Ingår i Nature Neuroscience, s. 2056-2072, 2024

• DOI för Advances and controversies in meningeal biology

Toward a granular molecular-anatomic map of the blood vasculature - single-cell RNA sequencing makes the leap

Betsholtz, Christer

Ingår i Upsala Journal of Medical Sciences, 2022

• DOI för Toward a granular molecular-anatomic map of the blood vasculature - single-cell RNA sequencing makes the leap
• Ladda ner fulltext (pdf) av Toward a granular molecular-anatomic map of the blood vasculature - single-cell RNA sequencing makes the leap

Identification, discrimination and heterogeneity of fibroblasts

Lendahl, Urban; Muhl, Lars; Betsholtz, Christer

Ingår i Nature Communications, 2022

• DOI för Identification, discrimination and heterogeneity of fibroblasts
• Ladda ner fulltext (pdf) av Identification, discrimination and heterogeneity of fibroblasts

The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes

Hariharan, Ashwini; Weir, Nick; Robertson, Colin; He, Liqun et al.

Ingår i Frontiers in Cellular Neuroscience, 2020

• DOI för The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes
• Ladda ner fulltext (pdf) av The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes

Emerging links between cerebrovascular and neurodegenerative diseases-a special role for pericytes

Lendahl, Urban; Nilsson, Per; Betsholtz, Christer

Ingår i EMBO Reports, 2019

• DOI för Emerging links between cerebrovascular and neurodegenerative diseases-a special role for pericytes

Heterogeneity and plasticity in healthy and atherosclerotic vasculature explored by single-cell sequencing

van Kuijk, Kim; Kuppe, Christoph; Betsholtz, Christer; Vanlandewijck, Michael et al.

Ingår i Cardiovascular Research, s. 1705-1715, 2019

• DOI för Heterogeneity and plasticity in healthy and atherosclerotic vasculature explored by single-cell sequencing

Alternative lymphatic endothelial progenitor cells compensate for the loss of non-venous-derived progenitors to form mesenteric lymphatic vessels

Zhang, Yang; Stritt, Simon; Martinez-Corral, Ines; Laviña, Bàrbara et al.

Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations: Cdc42 and vascular malformations

Laviña, Bàrbara; Castro, Marco; Niaudet, Colin; Bert, Cruys et al.