Hans Lennernäs

Column coupling for chiral LC-MS separation resolves triacylglycerol enantiomers and regioisomers in complex samples without flow recycling

Nilsson, Jenny M.; Balgoma, David; Stephansson, Edvin Dedering; Landström, Sofia et al.

Ingår i Talanta, 2027

• DOI för Column coupling for chiral LC-MS separation resolves triacylglycerol enantiomers and regioisomers in complex samples without flow recycling
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Characterization of hepatocellular carcinoma patient-derived organoids from patients receiving transarterial chemoembolization as a model for preclinical drug response assessment

Khaled, Jaafar; Sennefelt Nyman, Sofi; Dahlgren, David; Rorsman, Fredrik et al.

Ingår i Scientific Reports, 2026

• DOI för Characterization of hepatocellular carcinoma patient-derived organoids from patients receiving transarterial chemoembolization as a model for preclinical drug response assessment
• Ladda ner fulltext (pdf) av Characterization of hepatocellular carcinoma patient-derived organoids from patients receiving transarterial chemoembolization as a model for preclinical drug response assessment

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

Lerma-Clavero, Ada; Kopsida, Maria; Arendt, Nathalie; Lennernäs, Hans et al.

Ingår i FEBS Open Bio, 2026

• DOI för Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling
• Ladda ner fulltext (pdf) av Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

CombiCTx: screening diffusion gradients of anti-cancer drug combinations

Stelzl, Christina; Clavero, Ada Lerma; Camenisch, Selina; Simon, Benoit et al.

Ingår i Lab on a Chip, s. 695-710, 2026

• DOI för CombiCTx: screening diffusion gradients of anti-cancer drug combinations
• Ladda ner fulltext (pdf) av CombiCTx: screening diffusion gradients of anti-cancer drug combinations

Inhibition of PERK signaling suppresses tumor progression and blocks GP73-GRP78-dependent stromal activation in hepatocellular carcinoma

Khaled, Jaafar; Kopsida, Maria; Serafín, Tania Payo; Sennefelt Nyman, Sofi et al.

Ingår i Neoplasia, s. 101329-101329, 2026

• DOI för Inhibition of PERK signaling suppresses tumor progression and blocks GP73-GRP78-dependent stromal activation in hepatocellular carcinoma

Column coupling for chiral LC-MS separation resolves triacylglycerol enantiomers and regioisomers in complex samples without flow recycling

Nilsson, Jenny M.; Balgoma, David; Stephansson, Edvin Dedering; Landström, Sofia et al.

Ingår i Talanta, 2027

• DOI för Column coupling for chiral LC-MS separation resolves triacylglycerol enantiomers and regioisomers in complex samples without flow recycling
• Ladda ner fulltext (pdf) av Column coupling for chiral LC-MS separation resolves triacylglycerol enantiomers and regioisomers in complex samples without flow recycling

Characterization of hepatocellular carcinoma patient-derived organoids from patients receiving transarterial chemoembolization as a model for preclinical drug response assessment

Khaled, Jaafar; Sennefelt Nyman, Sofi; Dahlgren, David; Rorsman, Fredrik et al.

Ingår i Scientific Reports, 2026

• DOI för Characterization of hepatocellular carcinoma patient-derived organoids from patients receiving transarterial chemoembolization as a model for preclinical drug response assessment
• Ladda ner fulltext (pdf) av Characterization of hepatocellular carcinoma patient-derived organoids from patients receiving transarterial chemoembolization as a model for preclinical drug response assessment

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

Lerma-Clavero, Ada; Kopsida, Maria; Arendt, Nathalie; Lennernäs, Hans et al.

Ingår i FEBS Open Bio, 2026

• DOI för Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling
• Ladda ner fulltext (pdf) av Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

CombiCTx: screening diffusion gradients of anti-cancer drug combinations

Stelzl, Christina; Clavero, Ada Lerma; Camenisch, Selina; Simon, Benoit et al.

Ingår i Lab on a Chip, s. 695-710, 2026

• DOI för CombiCTx: screening diffusion gradients of anti-cancer drug combinations
• Ladda ner fulltext (pdf) av CombiCTx: screening diffusion gradients of anti-cancer drug combinations

Inhibition of PERK signaling suppresses tumor progression and blocks GP73-GRP78-dependent stromal activation in hepatocellular carcinoma

Khaled, Jaafar; Kopsida, Maria; Serafín, Tania Payo; Sennefelt Nyman, Sofi et al.

Ingår i Neoplasia, s. 101329-101329, 2026

• DOI för Inhibition of PERK signaling suppresses tumor progression and blocks GP73-GRP78-dependent stromal activation in hepatocellular carcinoma

Letter to the Editor Regarding "The Effect of Itraconazole on the Pharmacokinetics of Vepdegestrant, a PROteolysis TArgeting Chimera Estrogen Receptor Degrader, in Healthy Adult Participants " Recently Published by Tran and Colleagues

Niessen, Janis; Lennernäs, Hans; Lennernäs, Hans

Ingår i Clinical Therapeutics, s. 544-545, 2026

• DOI för Letter to the Editor Regarding "The Effect of Itraconazole on the Pharmacokinetics of Vepdegestrant, a PROteolysis TArgeting Chimera Estrogen Receptor Degrader, in Healthy Adult Participants " Recently Published by Tran and Colleagues

Formulation breakthroughs driving broader tyrosine kinase use

Lennernäs, Hans; Jesson, Gerald; Liljebris, Charlotta; Brisander, Magnus et al.

Ingår i British Journal of Clinical Pharmacology, s. 1525-1527, 2026

• DOI för Formulation breakthroughs driving broader tyrosine kinase use

Different metabolic pathways associated with total cortisol exposure and the cortisol time profile: a randomized crossover trial

McQueen, Johanna; Garner, Terence; Chantzichristos, Dimitrios; Lennernäs, Hans et al.

Ingår i Scientific Reports, 2026

• DOI för Different metabolic pathways associated with total cortisol exposure and the cortisol time profile: a randomized crossover trial
• Ladda ner fulltext (pdf) av Different metabolic pathways associated with total cortisol exposure and the cortisol time profile: a randomized crossover trial

A comparative study of idarubicin and doxorubicin in a chemically-induced in vivo mouse model for hepatocellular carcinoma

Lerma-Clavero, Ada; Kopsida, Maria; Arendt, Nathalie; Lennernäs, Hans et al.

Ingår i Biomedicine and Pharmacotherapy, 2025

• DOI för A comparative study of idarubicin and doxorubicin in a chemically-induced in vivo mouse model for hepatocellular carcinoma
• Ladda ner fulltext (pdf) av A comparative study of idarubicin and doxorubicin in a chemically-induced in vivo mouse model for hepatocellular carcinoma

Mapping the polar metabolome in Huh-7 liver cancer cells reveal the role of atorvastatin in enhancing chemotherapeutic efficacy of doxorubicin

Kopsida, Maria; Regtop, Lotta; Lennernäs, Hans; Hedeland, Mikael et al.

Ingår i Journal of Pharmaceutical and Biomedical Analysis, 2025

• DOI för Mapping the polar metabolome in Huh-7 liver cancer cells reveal the role of atorvastatin in enhancing chemotherapeutic efficacy of doxorubicin
• Ladda ner fulltext (pdf) av Mapping the polar metabolome in Huh-7 liver cancer cells reveal the role of atorvastatin in enhancing chemotherapeutic efficacy of doxorubicin

The Evolving Role of In Vitro-In Vivo Correlation in Model-Informed Drug Development: A Multi-Stakeholder Perspective

Chenel, Marylore; Fouliard, Sylvain; Hansson, Emma; Brendel, Karl et al.

Ingår i CPT, s. 1904-1907, 2025

• DOI för The Evolving Role of In Vitro-In Vivo Correlation in Model-Informed Drug Development: A Multi-Stakeholder Perspective
• Ladda ner fulltext (pdf) av The Evolving Role of In Vitro-In Vivo Correlation in Model-Informed Drug Development: A Multi-Stakeholder Perspective

Statin-mediated protection in chemotherapy-induced intestinal and cardiac toxicity: current perspectives

Arendt, Nathalie; Kopsida, Maria; Lennernäs, Hans; Sjöblom, Markus et al.

Ingår i European Journal of Pharmacology, 2025

• DOI för Statin-mediated protection in chemotherapy-induced intestinal and cardiac toxicity: current perspectives
• Ladda ner fulltext (pdf) av Statin-mediated protection in chemotherapy-induced intestinal and cardiac toxicity: current perspectives

Integrated Physiologically-based Pharmacokinetic Model with a Quantitative Systems Pharmacology and Toxicology Model for Statins in Disease Population. Part 2: MIDD and MIPD Applications

Prieto Garcia, Luna; Nordell, Pär; Ahlström, Christine; Lennernäs, Hans et al.

Ingår i AAPS Journal, 2025

• DOI för Integrated Physiologically-based Pharmacokinetic Model with a Quantitative Systems Pharmacology and Toxicology Model for Statins in Disease Population. Part 2: MIDD and MIPD Applications
• Ladda ner fulltext (pdf) av Integrated Physiologically-based Pharmacokinetic Model with a Quantitative Systems Pharmacology and Toxicology Model for Statins in Disease Population. Part 2: MIDD and MIPD Applications

Integrated Physiologically-Based Pharmacokinetic Model with a Quantitative Systems Pharmacology and Toxicology Model for Statins in Disease Population. Part 1: Model Development and Validation

Prieto Garcia, Luna; Nordell, Par; Ahlstrom, Christine; Lennernäs, Hans et al.

Ingår i AAPS Journal, 2025

• DOI för Integrated Physiologically-Based Pharmacokinetic Model with a Quantitative Systems Pharmacology and Toxicology Model for Statins in Disease Population. Part 1: Model Development and Validation
• Ladda ner fulltext (pdf) av Integrated Physiologically-Based Pharmacokinetic Model with a Quantitative Systems Pharmacology and Toxicology Model for Statins in Disease Population. Part 1: Model Development and Validation

Severe Impact of Omeprazole Timing on pH-Sensitive Dasatinib Absorption: Unveiling Substantial Drug-Drug Interaction

Andersson, Per; Brisander, Magnus; Liljebris, Charlotta; Jesson, Gerald et al.

Ingår i Journal of clinical pharmacology, s. 588-597, 2025

• DOI för Severe Impact of Omeprazole Timing on pH-Sensitive Dasatinib Absorption: Unveiling Substantial Drug-Drug Interaction
• Ladda ner fulltext (pdf) av Severe Impact of Omeprazole Timing on pH-Sensitive Dasatinib Absorption: Unveiling Substantial Drug-Drug Interaction

A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats

Niessen, Janis; Arendt, Nathalie; Sjöblom, Markus; Dubbelboer, Ilse R. et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, 2025

• DOI för A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats
• Ladda ner fulltext (pdf) av A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats

Ammonium bicarbonate buffers combined with hybrid surface technology columns improve the peak shape of strongly tailing lipids

Nilsson, Jenny M.; Balgoma, David; Pettersson, Curt; Lennernäs, Hans et al.

Ingår i Analytica Chimica Acta, 2024

• DOI för Ammonium bicarbonate buffers combined with hybrid surface technology columns improve the peak shape of strongly tailing lipids
• Ladda ner fulltext (pdf) av Ammonium bicarbonate buffers combined with hybrid surface technology columns improve the peak shape of strongly tailing lipids

Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells

Kopsida, Maria; Clavero, Ada Lerma; Khaled, Jaafar; Balgoma, David et al.

Ingår i Molecular Metabolism, 2024

• DOI för Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells
• Ladda ner fulltext (pdf) av Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells

Enhanced Bioavailability and Reduced Variability of Dasatinib and Sorafenib with a Novel Amorphous Solid Dispersion Technology Platform

Lennernäs, Hans; Brisander, Magnus; Liljebris, Charlotta; Jesson, Gerald et al.

Ingår i Clinical Pharmacology in Drug Development, s. 985-999, 2024

• DOI för Enhanced Bioavailability and Reduced Variability of Dasatinib and Sorafenib with a Novel Amorphous Solid Dispersion Technology Platform
• Ladda ner fulltext (pdf) av Enhanced Bioavailability and Reduced Variability of Dasatinib and Sorafenib with a Novel Amorphous Solid Dispersion Technology Platform

Physiologically based pharmacokinetics modeling and transporter proteomics to predict systemic and local liver and muscle disposition of statins

Garcia, Luna Prieto; Vildhede, Anna; Nordell, Pär; Ahlström, Christine et al.

Ingår i CPT, s. 1029-1043, 2024

• DOI för Physiologically based pharmacokinetics modeling and transporter proteomics to predict systemic and local liver and muscle disposition of statins
• Ladda ner fulltext (pdf) av Physiologically based pharmacokinetics modeling and transporter proteomics to predict systemic and local liver and muscle disposition of statins

Parameterization of Physiologically Based Biopharmaceutics Models: Workshop Summary Report

Pepin, Xavier; Arora, Sumit; Borges, Luiza; Cano-Vega, Mario et al.

Ingår i Molecular Pharmaceutics, s. 3697-3731, 2024

• DOI för Parameterization of Physiologically Based Biopharmaceutics Models: Workshop Summary Report
• Ladda ner fulltext (pdf) av Parameterization of Physiologically Based Biopharmaceutics Models: Workshop Summary Report

Melatonin mitigates chemotherapy-induced small intestinal atrophy in rats and reduces cytotoxicity in murine intestinal organoids

Peters, Karsten; Clavero, Ada Lerma; Kullenberg, Fredrik; Kopsida, Maria et al.

Ingår i PLOS ONE, 2024

• DOI för Melatonin mitigates chemotherapy-induced small intestinal atrophy in rats and reduces cytotoxicity in murine intestinal organoids
• Ladda ner fulltext (pdf) av Melatonin mitigates chemotherapy-induced small intestinal atrophy in rats and reduces cytotoxicity in murine intestinal organoids

Model-based interspecies scaling for predicting human pharmacokinetics of CB 4332, a complement factor I protein

Ayoun Alsoud, Rami; Le Moan, Natacha; Holten-Andersen, Lars; Knudsen, Tom et al.

Ingår i Journal of Pharmaceutical Sciences, s. 2895-2903, 2024

• DOI för Model-based interspecies scaling for predicting human pharmacokinetics of CB 4332, a complement factor I protein
• Ladda ner fulltext (pdf) av Model-based interspecies scaling for predicting human pharmacokinetics of CB 4332, a complement factor I protein

Development and validation of LC-MS/MS methods for the pharmacokinetic assessment of the PROTACs bavdeglutamide (ARV-110) and vepdegestrant (ARV-471)

Niessen, Janis; Nilsson, Jenny M.; Peters, Karsten; Indulkar, Anura et al.

Ingår i Journal of Pharmaceutical and Biomedical Analysis, 2024

• DOI för Development and validation of LC-MS/MS methods for the pharmacokinetic assessment of the PROTACs bavdeglutamide (ARV-110) and vepdegestrant (ARV-471)
• Ladda ner fulltext (pdf) av Development and validation of LC-MS/MS methods for the pharmacokinetic assessment of the PROTACs bavdeglutamide (ARV-110) and vepdegestrant (ARV-471)

Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells

Degerstedt, Oliver; O'Callaghan, Paul; Clavero, Ada Lerma; Gråsjö, Johan et al.

Ingår i Drug Delivery and Translational Research, s. 970-983, 2023

• DOI för Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells
• Ladda ner fulltext (pdf) av Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells

Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

Calitz, Carlemi; Rosenquist, Jenny; Degerstedt, Oliver; Khaled, Jaafar et al.

Ingår i Scientific Reports, 2023

• DOI för Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma
• Ladda ner fulltext (pdf) av Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

Despite warnings, co-medication with proton pump inhibitors and dasatinib is common in chronic myeloid leukemia, but XS004, a novel oral dasatinib formulation, provides reduced pH-dependence, minimizing undesirable drug-drug interactions

Larfors, Gunnar; Andersson, Per; Jesson, Gérald; Liljebris, Charlotta et al.

Ingår i European Journal of Haematology, s. 644-654, 2023

• DOI för Despite warnings, co-medication with proton pump inhibitors and dasatinib is common in chronic myeloid leukemia, but XS004, a novel oral dasatinib formulation, provides reduced pH-dependence, minimizing undesirable drug-drug interactions
• Ladda ner fulltext (pdf) av Despite warnings, co-medication with proton pump inhibitors and dasatinib is common in chronic myeloid leukemia, but XS004, a novel oral dasatinib formulation, provides reduced pH-dependence, minimizing undesirable drug-drug interactions

Novel food drug interaction mechanism involving acyclovir, chitosan and endogenous mucus

Garcia, Mauricio A.; Hensler, Gonul; Al-Gousous, Jozef; Pielenhofer, Jonas et al.

Ingår i Drug Metabolism and Pharmacokinetics, 2023

• DOI för Novel food drug interaction mechanism involving acyclovir, chitosan and endogenous mucus

The progression of doxorubicin-induced intestinal mucositis in rats

Kullenberg, Fredrik; Peters, Karsten; Luna-Marco, C.; Salomonsson, A. et al.

Ingår i Naunyn-Schmiedeberg's Archives of Pharmacology, s. 247-260, 2023

• DOI för The progression of doxorubicin-induced intestinal mucositis in rats
• Ladda ner fulltext (pdf) av The progression of doxorubicin-induced intestinal mucositis in rats

Anakinra and dexamethasone treatment of idarubicin-induced mucositis and diarrhoea in rats

Kullenberg, Fredrik; Peters, Karsten; Sjöblom, Markus; Heindryckx, Femke et al.

Ingår i Basic & Clinical Pharmacology & Toxicology, s. 507-516, 2023

• DOI för Anakinra and dexamethasone treatment of idarubicin-induced mucositis and diarrhoea in rats
• Ladda ner fulltext (pdf) av Anakinra and dexamethasone treatment of idarubicin-induced mucositis and diarrhoea in rats

Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival

Sennefelt Nyman, Sofi; Ahlström, Håkan; Dimopoulou, Angeliki; Dahlgren, David et al.

Ingår i BMJ Open, 2022

• DOI för Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival
• Ladda ner fulltext (pdf) av Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival

Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma

Khaled, Jaafar; Kopsida, Maria; Lennernäs, Hans; Heindryckx, Femke

Ingår i Cells, 2022

• DOI för Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma
• Ladda ner fulltext (pdf) av Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma

Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding

Balgoma, David; Kullenberg, Fredrik; Peters, Karsten; Dahlgren, David et al.

Ingår i Metabolites, 2022

• DOI för Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding
• Ladda ner fulltext (pdf) av Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding

Evaluation and validation of chemotherapy‐specific diarrhoea and histopathology in rats

Dahlgren, David; Rosenqvist, Evelina; Hellström, Per M.; Nygren, Peter et al.

Ingår i Basic & Clinical Pharmacology & Toxicology, s. 536-546, 2022

• DOI för Evaluation and validation of chemotherapy‐specific diarrhoea and histopathology in rats
• Ladda ner fulltext (pdf) av Evaluation and validation of chemotherapy‐specific diarrhoea and histopathology in rats

Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats

Peters, Karsten; Dahlgren, David; Egerszegi, Peter Pal; Lennernäs, Hans et al.

Ingår i International Journal of Molecular Sciences, 2022

• DOI för Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats
• Ladda ner fulltext (pdf) av Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats

Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats

Cano-Cebrian, Maria-Jose; Dahlgren, David; Kullenberg, Fredrik; Peters, Karsten et al.

Ingår i International Journal of Molecular Sciences, 2022

• DOI för Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats
• Ladda ner fulltext (pdf) av Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats

Drug diffusion in biomimetic hydrogels: importance for drug transport and delivery in non-vascular tumor tissue

Degerstedt, Oliver; Gråsjö, Johan; Norberg, Anton; Sjögren, Erik et al.

Ingår i European Journal of Pharmaceutical Sciences, 2022

• DOI för Drug diffusion in biomimetic hydrogels: importance for drug transport and delivery in non-vascular tumor tissue
• Ladda ner fulltext (pdf) av Drug diffusion in biomimetic hydrogels: importance for drug transport and delivery in non-vascular tumor tissue

Does the choice of applied physiologically-based pharmacokinetics platform matter?: A case study on simvastatin disposition and drug-drug interaction

Garcia, Luna Prieto; Lundahl, Anna; Ahlstrom, Christine; Vildhede, Anna et al.

Ingår i CPT, s. 1194-1209, 2022

• DOI för Does the choice of applied physiologically-based pharmacokinetics platform matter?: A case study on simvastatin disposition and drug-drug interaction
• Ladda ner fulltext (pdf) av Does the choice of applied physiologically-based pharmacokinetics platform matter?: A case study on simvastatin disposition and drug-drug interaction

Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death

Balgoma, David; Kullenberg, Fredrik; Calitz, Carlemi; Kopsida, Maria et al.

Ingår i Cells, 2021

• DOI för Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death
• Ladda ner fulltext (pdf) av Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death

Melatonin-Activated Receptor Signaling Pathways Mediate Protective Effects on Surfactant-Induced Increase in Jejunal Mucosal Permeability in Rats

Peters, Karsten; Dahlgren, David; Lennernäs, Hans; Sjöblom, Markus

Ingår i International Journal of Molecular Sciences, 2021

• DOI för Melatonin-Activated Receptor Signaling Pathways Mediate Protective Effects on Surfactant-Induced Increase in Jejunal Mucosal Permeability in Rats
• Ladda ner fulltext (pdf) av Melatonin-Activated Receptor Signaling Pathways Mediate Protective Effects on Surfactant-Induced Increase in Jejunal Mucosal Permeability in Rats

Fasted and fed state human duodenal fluids: Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability

Dahlgren, David; Venczel, M.; Ridoux, J. -P; Skjöld, C. et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 240-251, 2021

• DOI för Fasted and fed state human duodenal fluids: Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability
• Ladda ner fulltext (pdf) av Fasted and fed state human duodenal fluids: Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability

In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma

Kullenberg, Fredrik; Degerstedt, Oliver; Calitz, Carlemi; Pavlovic, Natasa et al.

Ingår i Cells, 2021

• DOI för In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma
• Ladda ner fulltext (pdf) av In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma

Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats

Dahlgren, David; Olander, Tobias; Sjöblom, Markus; Hedeland, Mikael et al.

Ingår i Acta Pharmaceutica Sinica B, s. 1667-1675, 2021

• DOI för Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats
• Ladda ner fulltext (pdf) av Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats

Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol

Dahlgren, David; Cano-Cebrian, Maria-Jose; Hellström, Per M.; Wanders, Alkwin et al.

Ingår i International Journal of Molecular Sciences, 2020

• DOI för Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol
• Ladda ner fulltext (pdf) av Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol

Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat

Dahlgren, David; Cano-Cebrian, Maria-Jose; Olander, Tobias; Hedeland, Mikael et al.

Ingår i Pharmaceutics, 2020

• DOI för Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat
• Ladda ner fulltext (pdf) av Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat

Effects of a novel combination of orlistat and acarbose on tolerability, appetite, and glucose metabolism in persons with obesity

Holmbäck, Ulf; Forslund, Anders; Gruden, Stefan; Alderborn, Göran et al.

Ingår i Obesity Science & Practice, s. 313-323, 2020

• DOI för Effects of a novel combination of orlistat and acarbose on tolerability, appetite, and glucose metabolism in persons with obesity
• Ladda ner fulltext (pdf) av Effects of a novel combination of orlistat and acarbose on tolerability, appetite, and glucose metabolism in persons with obesity

The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin

Dahlgren, David; Sjöblom, Markus; Hedeland, Mikael; Lennernäs, Hans

Ingår i Pharmaceutics, 2020

• DOI för The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin
• Ladda ner fulltext (pdf) av The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin

Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations

Van Wijk, Rob C; Ayoun Alsoud, Rami; Lennernäs, Hans; Simonsson, Ulrika S H

Ingår i Applied Sciences, 2020

• DOI för Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations
• Ladda ner fulltext (pdf) av Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations

Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption

Eriksson, Johanna; Sjögren, Erik; Lennernäs, Hans; Thörn, Helena

Ingår i AAPS Journal, 2020

• DOI för Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption
• Ladda ner fulltext (pdf) av Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption

Pulmonary drug absorption and systemic exposure in human: Predictions using physiologically based biopharmaceutics modeling

Eriksson, Johanna; Thorn, Helena; Lennernäs, Hans; Sjögren, Erik

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 191-202, 2020

• DOI för Pulmonary drug absorption and systemic exposure in human: Predictions using physiologically based biopharmaceutics modeling

Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: History, methodology and applications

Augustijns, Patrick; Vertzoni, Maria; Reppas, Christos; Langguth, Peter et al.

Ingår i European Journal of Pharmaceutical Sciences, 2020

• DOI för Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: History, methodology and applications
• Ladda ner fulltext (pdf) av Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: History, methodology and applications

Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project

Abrahamsson, B.; McAllister, M.; Augustijns, P.; Zane, P. et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 236-247, 2020

• DOI för Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project

ICH M9 Guideline in Development on Biopharmaceutics Classification System-Based Biowaivers: An Industrial Perspective from the IQ Consortium

Bransford, Philip; Cook, Jack; Gupta, Manish; Haertter, Sebastian et al.

Ingår i Molecular Pharmaceutics, s. 361-372, 2020

• DOI för ICH M9 Guideline in Development on Biopharmaceutics Classification System-Based Biowaivers: An Industrial Perspective from the IQ Consortium

Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality

Ahnfelt, Emelie; Degerstedt, Oliver; Lilienberg, Elsa; Sjögren, Erik et al.

Ingår i Journal of Drug Delivery Science and Technology, 2019

• DOI för Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality
• Ladda ner fulltext (pdf) av Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality

Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile

Dubbelboer, Ilse R; Pavlovic, Natasa; Heindryckx, Femke; Sjögren, Erik et al.

Ingår i Cancers, 2019

• DOI för Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile
• Ladda ner fulltext (pdf) av Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile

Pulmonary Dissolution of Poorly Soluble Compounds Studied in an ex Vivo Rat Lung Model

Eriksson, Johanna; Thorn, Helena; Sjögren, Erik; Holmsten, Lisa et al.

Ingår i Molecular Pharmaceutics, s. 3053-3064, 2019

• DOI för Pulmonary Dissolution of Poorly Soluble Compounds Studied in an ex Vivo Rat Lung Model

Intestinal absorption-modifying excipients: A current update on preclinical in vivo evaluations

Dahlgren, David; Sjöblom, Markus; Lennernäs, Hans

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 411-420, 2019

• DOI för Intestinal absorption-modifying excipients: A current update on preclinical in vivo evaluations

Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 387-395, 2019

• DOI för Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model

Dahlgren, David; Roos, Carl; Peters, Karsten; Lundqvist, A. et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 31-37, 2019

• DOI för Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model

Rat intestinal drug permeability: A status report and summary of repeated determinations

Dubbelboer, Ilse R; Dahlgren, David; Sjögren, Erik; Lennernäs, Hans

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 364-376, 2019

• DOI för Rat intestinal drug permeability: A status report and summary of repeated determinations

Physiologically based pharmacokinetic model predictions of ivosidenib (AG-120) as a victim and perpetrator of drug–drug interactions

Garcia, Luna Prieto; Janzen, David; Kanebratt, Kajsa; Ericsson, Hans et al.

Ingår i Drug Metabolism and Pharmacokinetics, 2019

• DOI för Physiologically based pharmacokinetic model predictions of ivosidenib (AG-120) as a victim and perpetrator of drug–drug interactions

Physiologically Based Pharmacokinetic Model of Itraconazole and Two of Its Metabolites to Improve the Predictions and the Mechanistic Understanding of CYP3A4 Drug-Drug Interactions

Garcia, Luna Prieto; Janzén, David; Kanebratt, Kajsa P.; Ericsson, Hans et al.

Ingår i Drug Metabolism And Disposition, s. 1420-1433, 2018

• DOI för Physiologically Based Pharmacokinetic Model of Itraconazole and Two of Its Metabolites to Improve the Predictions and the Mechanistic Understanding of CYP3A4 Drug-Drug Interactions

Porcine and Human In Vivo Simulations for Doxorubicin-Containing Formulations Used in Locoregional Hepatocellular Carcinoma Treatment

Dubbelboer, Ilse R; Sjögren, Erik; Lennernäs, Hans

Ingår i AAPS Journal, 2018

• DOI för Porcine and Human In Vivo Simulations for Doxorubicin-Containing Formulations Used in Locoregional Hepatocellular Carcinoma Treatment
• Ladda ner fulltext (pdf) av Porcine and Human In Vivo Simulations for Doxorubicin-Containing Formulations Used in Locoregional Hepatocellular Carcinoma Treatment

Single bead investigation of a clinical drug delivery system – a novel release mechanism

Ahnfelt, Emelie; Al-Tikriti, Yassir; Sjögren, Erik; Lennernäs, Hans et al.

Ingår i Journal of Controlled Release, s. 235-247, 2018

• DOI för Single bead investigation of a clinical drug delivery system – a novel release mechanism
• Ladda ner fulltext (pdf) av Single bead investigation of a clinical drug delivery system – a novel release mechanism

Time-dependent effects on small intestinal transport by absorption-modifying excipients

Dahlgren, David; Roos, Carl; Lundqvist, A.; Tannergren, C. et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 19-28, 2018

• DOI för Time-dependent effects on small intestinal transport by absorption-modifying excipients

Mechanistic modelling of intestinal drug absorption: the in vivo effects of nanoparticles, hydrodynamics, and colloidal structures

Roos, Carl; Westergren, Jan; Dahlgren, David; Lennernäs, Hans et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 70-76, 2018

• DOI för Mechanistic modelling of intestinal drug absorption: the in vivo effects of nanoparticles, hydrodynamics, and colloidal structures

Jejunal absorption of aprepitant from nanosuspensions: Role of particle size, prandial state and mucus layer.

Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 222-230, 2018

• DOI för Jejunal absorption of aprepitant from nanosuspensions: Role of particle size, prandial state and mucus layer.

Summary of the In Vivo Predictive Dissolution (iPD) - Oral Drug Delivery (ODD) Conference 2018

Hens, Bart; Al-Gousous, Jozef; Wang, Kai; Salehi, Niloufar et al.

Ingår i DISSOLUTION TECHNOLOGIES, s. 50-53, 2018

• DOI för Summary of the In Vivo Predictive Dissolution (iPD) - Oral Drug Delivery (ODD) Conference 2018

Effect of absorption-modifying excipients, hypotonicity, and enteric neural activity in an in vivo model for small intestinal transport.

Dahlgren, David; Roos, Carl; Lundqvist, A; Tannergren, C et al.

Ingår i International Journal of Pharmaceutics, s. 239-248, 2018

• DOI för Effect of absorption-modifying excipients, hypotonicity, and enteric neural activity in an in vivo model for small intestinal transport.

The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs.

Dahlgren, David; Roos, Carl; Johansson, P; Tannergren, C et al.

Ingår i International Journal of Pharmaceutics, s. 158-168, 2018

• DOI för The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs.

Reply to "Comment on 'In Vivo Drug Delivery Performance of Lipiodol-Based Emulsion or Drug-Eluting Beads in Patients with Hepatocellular Carcinoma'"

Dubbelboer, Ilse R; Lilienberg, Elsa; Karalli, Amar; Axelsson, Rimma et al.

Ingår i Molecular Pharmaceutics, s. 336-340, 2018

• DOI för Reply to "Comment on 'In Vivo Drug Delivery Performance of Lipiodol-Based Emulsion or Drug-Eluting Beads in Patients with Hepatocellular Carcinoma'"

Pulmonary absorption - estimation of effective pulmonary permeability and tissue retention of ten drugs using an ex vivo rat model and computational analysis

Eriksson, Johanna; Sjögren, Erik; Thörn, Helena; Rubin, Katarina et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 1-12, 2018

• DOI för Pulmonary absorption - estimation of effective pulmonary permeability and tissue retention of ten drugs using an ex vivo rat model and computational analysis

An Intraprostatic Modified Release Formulation of Antiandrogen 2-Hydroxyflutamide for Localized Prostate Cancer

Tammela, T L; Häggman, Michael; Ladjevardi, Sam; Taari, K et al.

Ingår i Journal of Urology, s. 1333-1339, 2017

• DOI för An Intraprostatic Modified Release Formulation of Antiandrogen 2-Hydroxyflutamide for Localized Prostate Cancer

Preclinical Effect of Absorption Modifying Excipients on Rat Intestinal Transport of Model Compounds and the Mucosal Barrier Marker ⁵¹Cr-EDTA

Dahlgren, David; Roos, Carl; Lundqvist, Anders; Tannergren, Christer et al.

Ingår i Molecular Pharmaceutics, s. 4243-4251, 2017

• DOI för Preclinical Effect of Absorption Modifying Excipients on Rat Intestinal Transport of Model Compounds and the Mucosal Barrier Marker ⁵¹Cr-EDTA

Computational fluid dynamics (CFD) studies of a miniaturized dissolution system

Frenning, Göran; Ahnfelt, Emelie; Sjögren, Erik; Lennernäs, Hans

Ingår i International Journal of Pharmaceutics, s. 274-281, 2017

• DOI för Computational fluid dynamics (CFD) studies of a miniaturized dissolution system
• Ladda ner fulltext (pdf) av Computational fluid dynamics (CFD) studies of a miniaturized dissolution system

In vivo Drug Delivery Performance of Lipiodol-based Emulsion or Drug-eluting Beads in Patients with Hepatocellular Carcinoma

Lilienberg, Elsa; Dubbelboer, Ilse R.; Karalli, Amar; Axelsson, Rimma et al.

Ingår i Molecular Pharmaceutics, s. 448-458, 2017

• DOI för In vivo Drug Delivery Performance of Lipiodol-based Emulsion or Drug-eluting Beads in Patients with Hepatocellular Carcinoma

Regional Intestinal Permeability in Rats: A Comparison of Methods

Roos, Carl; Dahlgren, David; Sjögren, Erik; Tannergren, Christer et al.

Ingår i Molecular Pharmaceutics, s. 4252-4261, 2017

• DOI för Regional Intestinal Permeability in Rats: A Comparison of Methods

In Vivo Mechanisms of Intestinal Drug Absorption from Aprepitant Nanoformulations

Roos, Carl; Dahlgren, David; Berg, Staffan; Westergren, Jan et al.

Ingår i Molecular Pharmaceutics, s. 4233-4242, 2017

• DOI för In Vivo Mechanisms of Intestinal Drug Absorption from Aprepitant Nanoformulations

IMI - oral biopharmaceutics tools project - evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

Margolskee, Alison; Darwich, Adam S.; Pepin, Xavier; Pathak, Shriram M. et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 598-609, 2017

• DOI för IMI - oral biopharmaceutics tools project - evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

Darwich, Adam S.; Margolskee, Alison; Pepin, Xavier; Aarons, Leon et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 626-642, 2017

• DOI för IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

Margolskee, Alison; Darwich, Adam S.; Pepin, Xavier; Aarons, Leon et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 610-625, 2017

• DOI för IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

In Vivo Predictive Dissolution (IPD) and Biopharmaceutical Modeling and Simulation: Future Use of Modern Approaches and Methodologies in a Regulatory Context

Lennernäs, Hans; Lindahl, A.; Van Peer, A.; Ollier, C. et al.

Ingår i Molecular Pharmaceutics, s. 1307-1314, 2017

• DOI för In Vivo Predictive Dissolution (IPD) and Biopharmaceutical Modeling and Simulation: Future Use of Modern Approaches and Methodologies in a Regulatory Context

Optimization of the Ussing chamber setup with excised rat intestinal segments for dissolution/permeation experiments of poorly soluble drugs

Forner, Kristin; Roos, Carl; Dahlgren, David; Kesisoglou, Filippos et al.

Ingår i Drug Development and Industrial Pharmacy, s. 338-346, 2017

• DOI för Optimization of the Ussing chamber setup with excised rat intestinal segments for dissolution/permeation experiments of poorly soluble drugs

A Model -Based Approach To Assessing the Importance of Intracellular Binding Sites in Doxorubicin Disposition

Dubbelboer, Ilse R.; Lilienberg, Elsa; Sjögren, Erik; Lennernäs, Hans

Ingår i Molecular Pharmaceutics, s. 686-698, 2017

• DOI för A Model -Based Approach To Assessing the Importance of Intracellular Binding Sites in Doxorubicin Disposition

Lipiodol does not affect the tissue distribution of intravenous doxorubicin infusion in pigs

Lilienberg, Elsa; Dubbelboer, Ilse R; Sjögren, Erik; Lennernäs, Hans

Ingår i Journal of Pharmacy and Pharmacology (JPP), s. 135-142, 2017

• DOI för Lipiodol does not affect the tissue distribution of intravenous doxorubicin infusion in pigs

Regional Intestinal Permeability of Three Model Drugs in Human

Dahlgren, David; Roos, Carl; Lundqvist, Anders; Abrahamsson, Bertil et al.

Ingår i Molecular Pharmaceutics, s. 3013-3021, 2016

• DOI för Regional Intestinal Permeability of Three Model Drugs in Human

In Vitro Release Mechanisms of Doxorubicin From a Clinical Bead Drug-Delivery System

Ahnfelt, Emelie; Sjögren, Erik; Hansson, Per; Lennernäs, Hans

Ingår i Journal of Pharmaceutical Sciences, s. 3387-3398, 2016

• DOI för In Vitro Release Mechanisms of Doxorubicin From a Clinical Bead Drug-Delivery System

Regional Intestinal Permeability in Dogs: Biopharmaceutical Aspects for Development of Oral Modified-Release Dosage Forms

Dahlgren, David; Roos, Carl; Johansson, Pernilla; Lundqvist, Anders et al.

Ingår i Molecular Pharmaceutics, s. 3022-3033, 2016

• DOI för Regional Intestinal Permeability in Dogs: Biopharmaceutical Aspects for Development of Oral Modified-Release Dosage Forms

Achieving a physiological cortisol profile with once-daily dual-release hydrocortisone: a pharmacokinetic study

Johannsson, Gudmundur; Lennernäs, Hans; Marelli, Claudio; Rockich, Kevin et al.

Ingår i European Journal of Endocrinology, s. 85-93, 2016

• DOI för Achieving a physiological cortisol profile with once-daily dual-release hydrocortisone: a pharmacokinetic study
• Ladda ner fulltext (pdf) av Achieving a physiological cortisol profile with once-daily dual-release hydrocortisone: a pharmacokinetic study

Translating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug Absorption

Olivares-Morales, Andres; Lennernäs, Hans; Aarons, Leon; Rostami-Hodjegan, Amin

Ingår i AAPS Journal, s. 1177-1192, 2015

• DOI för Translating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug Absorption

A miniaturized in vitro release method for investigating drug-release mechanisms

Ahnfelt, Emelie; Sjögren, Erik; Axén, N.; Lennernäs, Hans

Ingår i International Journal of Pharmaceutics, s. 339-349, 2015

• DOI för A miniaturized in vitro release method for investigating drug-release mechanisms
• Ladda ner fulltext (pdf) av A miniaturized in vitro release method for investigating drug-release mechanisms

Human in Vivo Regional Intestinal Permeability: Quantitation Using Site-Specific Drug Absorption Data

Sjögren, Erik; Dahlgren, David; Roos, Carl; Lennernas, Hans

Ingår i Molecular Pharmaceutics, s. 2026-2039, 2015

• DOI för Human in Vivo Regional Intestinal Permeability: Quantitation Using Site-Specific Drug Absorption Data

Effect on the Gastrointestinal Absorption of Drugs from Different Classes in the Biopharmaceutics Classification System, When Treating with Liraglutide

Malm-Erjefalt, Monika; Ekblom, Marianne; Vouis, Jan; Zdravkovic, Milan et al.

Ingår i Molecular Pharmaceutics, s. 4166-4173, 2015

• DOI för Effect on the Gastrointestinal Absorption of Drugs from Different Classes in the Biopharmaceutics Classification System, When Treating with Liraglutide

Treatment of intermediate stage hepatocellular carcinoma: a review of intrahepatic doxorubicin drug-delivery systems

Dubbelboer, Ilse R; Lilienberg, Elsa; Ahnfelt, Emelie; Sjögren, Erik et al.

Ingår i Therapeutic delivery, s. 447-466, 2014

• DOI för Treatment of intermediate stage hepatocellular carcinoma: a review of intrahepatic doxorubicin drug-delivery systems

Effects of verapamil on the pharmacokinetics and hepatobiliary disposition of fexofenadine in pigs

Sjögren, Erik; Hedeland, Mikael; Bondesson, Ulf; Lennernäs, Hans

Ingår i European Journal of Pharmaceutical Sciences, s. 214-223, 2014

• DOI för Effects of verapamil on the pharmacokinetics and hepatobiliary disposition of fexofenadine in pigs

The Effects of Lipiodol and Cyclosporin A on the Hepatobiliary Disposition of Doxorubicin in Pigs

Dubbelboer, Ilse R; Lilienberg, Elsa; Hedeland, Mikael; Bondesson, Ulf et al.

Ingår i Molecular Pharmaceutics, s. 1301-1313, 2014

• DOI för The Effects of Lipiodol and Cyclosporin A on the Hepatobiliary Disposition of Doxorubicin in Pigs

Theme Issue 5th World Conference on Drug Absorption, Transport and Delivery

Lennernäs, Hans; Langguth, Peter; Yamashita, Shinji; Crommelin, Daan J. A.

Ingår i European Journal of Pharmaceutical Sciences, s. 1-1, 2014

• DOI för Theme Issue 5th World Conference on Drug Absorption, Transport and Delivery

In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

Sjögren, Erik; Abrahamsson, Bertil; Augustijns, Patrick; Becker, Dieter et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 99-151, 2014

• DOI för In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

High-resolution mass spectrometric investigation of the phase I and II metabolites of finasteride in pig plasma, urine and bile

Lundahl, Anna; Åberg, Annica Tevell; Bondesson, Ulf; Lennernäs, Hans et al.

Ingår i Xenobiotica, s. 498-510, 2014

• DOI för High-resolution mass spectrometric investigation of the phase I and II metabolites of finasteride in pig plasma, urine and bile

The Biopharmaceutics Risk Assessment Roadmap for Optimizing Clinical Drug Product Performance

Selen, Arzu; Dickinson, Paul A.; Mullertz, Anette; Crison, John R. et al.

Ingår i Journal of Pharmaceutical Sciences, s. 3377-3397, 2014

• DOI för The Biopharmaceutics Risk Assessment Roadmap for Optimizing Clinical Drug Product Performance

Oral biopharmaceutics-current status and identified gaps of understanding

Lennernäs, Hans; Abrahamsson, Peter; Langguth, Bertil

Ingår i European Journal of Pharmaceutical Sciences, s. 98-98, 2014

• DOI för Oral biopharmaceutics-current status and identified gaps of understanding

Pharmacokinetics of an Injectable Modified-Release 2-Hydroxyflutamide Formulation in the Human Prostate Gland Using a Semiphysiologically Based Biopharmaceutical Model

Sjögren, Erik; Tammela, Teuvo L.; Lennernas, Bo; Taari, Kimmo et al.

Ingår i Molecular Pharmaceutics, s. 3097-3111, 2014

• DOI för Pharmacokinetics of an Injectable Modified-Release 2-Hydroxyflutamide Formulation in the Human Prostate Gland Using a Semiphysiologically Based Biopharmaceutical Model

Investigation of Hepatobiliary Disposition of Doxorubicin Following Intrahepatic Delivery of Different Dosage Forms

Lilienberg, Elsa; Ebeling-Barbier, Charlotte; Nyman, Rickard; Hedeland, Mikael et al.

Ingår i Molecular Pharmaceutics, s. 131-144, 2014

• DOI för Investigation of Hepatobiliary Disposition of Doxorubicin Following Intrahepatic Delivery of Different Dosage Forms

Evaluation of the use of Classical Nucleation Theory for predicting intestinal crystalline precipitation of two weakly basic BSC class II drugs

Carlert, Sara; Lennernäs, Hans; Abrahamsson, Bertil

Ingår i European Journal of Pharmaceutical Sciences, s. 17-27, 2014

• DOI för Evaluation of the use of Classical Nucleation Theory for predicting intestinal crystalline precipitation of two weakly basic BSC class II drugs

Prospective evaluation of long-term safety of dual-release hydrocortisone replacement administered once daily in patients with adrenal insufficiency

Nilsson, A. G.; Marelli, C.; Fitts, D.; Bergthorsdottir, R. et al.

Ingår i European Journal of Endocrinology, s. 369-377, 2014

• DOI för Prospective evaluation of long-term safety of dual-release hydrocortisone replacement administered once daily in patients with adrenal insufficiency

Carbon Dioxide-Mediated Generation of Hybrid Nanoparticles for Improved Bioavailability of Protein Kinase Inhibitors

Jesson, Gerald; Brisander, Magnus; Andersson, Per; Demirbuker, Mustafa et al.

Ingår i Pharmaceutical research, s. 694-705, 2014

• DOI för Carbon Dioxide-Mediated Generation of Hybrid Nanoparticles for Improved Bioavailability of Protein Kinase Inhibitors

Combined in Vitro-in Vivo Approach To Assess the Hepatobiliary Disposition of a Novel Oral Thrombin Inhibitor

Matsson, Elin M.; Eriksson, Ulf G.; Palm, Johan E.; Artursson, Per et al.

Ingår i Molecular Pharmaceutics, s. 4252-4262, 2013

• DOI för Combined in Vitro-in Vivo Approach To Assess the Hepatobiliary Disposition of a Novel Oral Thrombin Inhibitor

In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: Application of the mechanistic absorption model GI-Sim

Sjögren, Erik; Westergren, Jan; Grant, Iain; Hanisch, Gunilla et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 679-698, 2013

• DOI för In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: Application of the mechanistic absorption model GI-Sim

Binding processes determine the stereoselective intestinal and hepatic extraction of verapamil in vivo

Thörn, Helena Anna; Sjögren, Erik; Dickinson, Paul Alfred; Lennernäs, Hans

Ingår i Molecular Pharmaceutics, s. 3034-3045, 2012

• DOI för Binding processes determine the stereoselective intestinal and hepatic extraction of verapamil in vivo

Extensive intestinal glucuronidation of raloxifene in vivo in pigs and impact for oral drug delivery

Thörn, Helena Anna; Yasin, Mohammed; Dickinson, Paul Alfred; Lennernäs, Hans

Ingår i Xenobiotica, s. 917-928, 2012

• DOI för Extensive intestinal glucuronidation of raloxifene in vivo in pigs and impact for oral drug delivery

In Vivo Dog Intestinal Precipitation of Mebendazole: A Basic BCS Class II Drug

Carlert, Sara; Åkesson, Pernilla; Jerndal, Gunilla; Lindfors, Lennart et al.

Ingår i Molecular Pharmaceutics, s. 2903-2911, 2012

• DOI för In Vivo Dog Intestinal Precipitation of Mebendazole: A Basic BCS Class II Drug

The pharmacokinetics and hepatic disposition of repaglinide in pigs: mechanistic modeling of metabolism and transport

Sjögren, Erik; Bredberg, Ulf; Lennernäs, Hans

Ingår i Molecular Pharmaceutics, s. 823-841, 2012

• DOI för The pharmacokinetics and hepatic disposition of repaglinide in pigs: mechanistic modeling of metabolism and transport

Assessment of enzymatic prodrug stability in human, dog and simulated intestinal fluids

Borde, A. S.; Karlsson, E. M.; Andersson, K.; Bjorhall, K. et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 630-637, 2012

• DOI för Assessment of enzymatic prodrug stability in human, dog and simulated intestinal fluids

Levodopa infusion combined with entacapone or tolcapone in Parkinson disease: a pilot trial

Nyholm, Dag; Johansson, Anders; Lennernäs, Hans; Askmark, Håkan

Ingår i European Journal of Neurology, s. 820-826, 2012

• DOI för Levodopa infusion combined with entacapone or tolcapone in Parkinson disease: a pilot trial

Improved Cortisol Exposure-Time Profile and Outcome in Patients with Adrenal Insufficiency: A Prospective Randomized Trial of a Novel Hydrocortisone Dual-Release Formulation

Johannsson, G.; Nilsson, A. G.; Bergthorsdottir, R.; Burman, P. et al.

Ingår i Journal of Clinical Endocrinology and Metabolism, s. 473-481, 2012

• DOI för Improved Cortisol Exposure-Time Profile and Outcome in Patients with Adrenal Insufficiency: A Prospective Randomized Trial of a Novel Hydrocortisone Dual-Release Formulation

The Fraction Dose Absorbed, in Humans, and High Jejunal Human Permeability Relationship

Dahan, Arik; Lennernäs, Hans; Amidon, Gordon L.

Ingår i Molecular Pharmaceutics, s. 1847-1851, 2012

• DOI för The Fraction Dose Absorbed, in Humans, and High Jejunal Human Permeability Relationship

Bioequivalence of Oral Products and the Biopharmaceutics Classification System: Science, Regulation, and Public Policy

Amidon, K. S.; Langguth, P.; Lennernäs, Hans; Yu, L. et al.

Ingår i Clinical Pharmacology and Therapeutics, s. 467-470, 2011

• DOI för Bioequivalence of Oral Products and the Biopharmaceutics Classification System: Science, Regulation, and Public Policy

Drug metabolism of CYP3A4, CYP2C9 and CYP2D6 substrates in pigs and humans

Thörn, Helena Anna; Lundahl, Anna; Schrickx, Johannes Antonius; Dickinson, Paul Alfred et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 89-98, 2011

• DOI för Drug metabolism of CYP3A4, CYP2C9 and CYP2D6 substrates in pigs and humans

In Vivo Investigation in Pigs of Intestinal Absorption, Hepatobiliary Disposition, and Metabolism of the 5 alpha-Reductase Inhibitor Finasteride and the Effects of Coadministered Ketoconazole

Lundahl, Anna; Hedeland, Mikael; Bondesson, Ulf; Lennernäs, Hans

Ingår i Drug Metabolism And Disposition, s. 847-857, 2011

• DOI för In Vivo Investigation in Pigs of Intestinal Absorption, Hepatobiliary Disposition, and Metabolism of the 5 alpha-Reductase Inhibitor Finasteride and the Effects of Coadministered Ketoconazole

The BCS, BDDCS, and regulatory guidances

Chen, Mei-Ling; Amidon, Gordon L; Benet, Leslie Z; Lennernäs, Hans et al.

Ingår i Pharmaceutical research, s. 1774-1778, 2011

• DOI för The BCS, BDDCS, and regulatory guidances

Optimal experimental design for assessment of enzyme kinetics in a drug discovery screening environment

Sjögren, Erik; Nyberg, Joakim; Magnusson, Mats O.; Lennernäs, Hans et al.

Ingår i Drug Metabolism And Disposition, s. 858-863, 2011

• DOI för Optimal experimental design for assessment of enzyme kinetics in a drug discovery screening environment

Effects of ketoconazole on the in vivo biotransformation and hepatobiliary transport of the thrombin inhibitor AZD0837 in pigs

Matsson, Elin; Palm, Johan E.; Eriksson, Ulf; Bottner, Pernilla et al.

Ingår i Drug Metabolism And Disposition, s. 239-246, 2011

• DOI för Effects of ketoconazole on the in vivo biotransformation and hepatobiliary transport of the thrombin inhibitor AZD0837 in pigs

Biliary Excretion of Ximelagatran and Its Metabolites and the Influence of Erythromycin Following Intraintestinal Administration to Healthy Volunteers

Matsson, Elin; Eriksson, Ulf; Knutson, Lars; Hoffmann, Kurt-Jurgen et al.

Ingår i Journal of clinical pharmacology, s. 770-783, 2011

• DOI för Biliary Excretion of Ximelagatran and Its Metabolites and the Influence of Erythromycin Following Intraintestinal Administration to Healthy Volunteers

Sublingual administration of fentanyl to cancer patients is an effective treatment for breakthrough pain: results from a randomized phase II study

Lennernäs, Bo; Frank-Lissbrant, Ingela; Lennernäs, Hans; Kälkner, Karl Mikael et al.

Ingår i Palliative Medicine, s. 286-293, 2010

• DOI för Sublingual administration of fentanyl to cancer patients is an effective treatment for breakthrough pain: results from a randomized phase II study

Coexistence of passive and carrier-mediated processes in drug transport

Sugano, Kiyohiko; Kansy, Manfred; Artursson, Per; Avdeef, Alex et al.

Ingår i Nature reviews. Drug discovery, s. 597-614, 2010

• DOI för Coexistence of passive and carrier-mediated processes in drug transport

Gastrointestinal metabolism of a vegetable-oil emulsion in healthy subjects

Knutson, Lars; Koenders, Damiet J. P. C.; Fridblom, Helle; Viberg, Annika et al.

Ingår i American Journal of Clinical Nutrition, s. 515-524, 2010

• DOI för Gastrointestinal metabolism of a vegetable-oil emulsion in healthy subjects

High-Permeability Criterion for BCS Classification: Segmental/pH Dependent Permeability Considerations

Dahan, Arik; Miller, Jonathan M.; Hilfinger, John M.; Yamashita, Shinji et al.

Ingår i Molecular pharmaceutics, s. 1827-1834, 2010

• DOI för High-Permeability Criterion for BCS Classification: Segmental/pH Dependent Permeability Considerations

Predicting intestinal precipitation: a case example for a basic BCS class II drug

Carlert, Sara; Pålsson, Anna; Hanisch, Gunilla; von Corswant, Christian et al.

Ingår i Pharmaceutical research, s. 2119-2130, 2010

• DOI för Predicting intestinal precipitation: a case example for a basic BCS class II drug

The metabolic impact of improving diurnal cortisol exposure in patients with adrenal insufficiency

Johannsson, Gudmundur; Lennernäs, Hans; Skrtic, Stanko

Ingår i Endocrine journal, 2010

Hepatic disposition of ximelagatran and its metabolites in pig; prediction of the impact of membrane transporters through a simple disposition model

Sjögren, Erik; Bredberg, Ulf; Allard, Erik; Arvidsson, Björn et al.

Ingår i Pharmaceutical research, s. 597-607, 2010

• DOI för Hepatic disposition of ximelagatran and its metabolites in pig; prediction of the impact of membrane transporters through a simple disposition model

The Effect of Acute Administration of Rifampicin and Imatinib on the Enterohepatic Transport of Rosuvastatin In Vivo

Bergman, Ebba; Hedeland, Mikael; Bondesson, Ulf; Lennernäs, Hans

Ingår i Xenobiotica, s. 558-568, 2010

• DOI för The Effect of Acute Administration of Rifampicin and Imatinib on the Enterohepatic Transport of Rosuvastatin In Vivo

Effect of a Single Gemfibrozil Dose on the Pharmacokinetics of Rosuvastatin in Bile and Plasma in Healthy Volunteers

Bergman, Ebba; Matsson, Elin M; Hedeland, Mikael; Bondesson, Ulf et al.

Ingår i Journal of clinical pharmacology, s. 1039-1049, 2010

• DOI för Effect of a Single Gemfibrozil Dose on the Pharmacokinetics of Rosuvastatin in Bile and Plasma in Healthy Volunteers

Circadian rhythmicity in levodopa pharmacokinetics in patients with Parkinson disease

Nyholm, Dag; Lennernäs, Hans; Johansson, Anders; Estrada, Matias et al.

Ingår i Clinical neuropharmacology, s. 181-185, 2010

• DOI för Circadian rhythmicity in levodopa pharmacokinetics in patients with Parkinson disease

Toward an increased understanding of the barriers to colonic drug absorption in humans: implications for early controlled release candidate assessment

Tannergren, Christer; Bergendal, Anna; Lennernäs, Hans; Abrahamsson, Bertil

Ingår i Molecular pharmaceutics, s. 60-73, 2009

• DOI för Toward an increased understanding of the barriers to colonic drug absorption in humans: implications for early controlled release candidate assessment

The effect of St. John's wort on the pharmacokinetics, metabolism and biliary excretion of finasteride and its metabolites in healthy men

Lundahl, Anna; Hedeland, Mikael; Bondesson, Ulf; Knutson, Lars et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 433-443, 2009

• DOI för The effect of St. John's wort on the pharmacokinetics, metabolism and biliary excretion of finasteride and its metabolites in healthy men

Online capillary solid phase extraction and liquid chromatographic separation with quantitative tandem mass spectrometric detection (SPE-LC-MS/MS) of ximelagatran and its metabolites in a complex matrix.

Arvidsson, Björn; Allard, Erik; Sjögren, Erik; Lennernäs, Hans et al.

Ingår i Journal of chromatography. B, s. 291-297, 2009

• DOI för Online capillary solid phase extraction and liquid chromatographic separation with quantitative tandem mass spectrometric detection (SPE-LC-MS/MS) of ximelagatran and its metabolites in a complex matrix.

The multiple depletion curves method provides accurate estimates of intrinsic clearance (CLint), maximum velocity of the metabolic reaction (Vmax), and Michaelis constant (Km): accuracy and robustness evaluated through experimental data and Monte Carlo simulations

Sjögren, Erik; Lennernäs, Hans; Andersson, Tommy B; Gråsjö, Johan et al.

Ingår i Drug Metabolism And Disposition, s. 47-58, 2009

• DOI för The multiple depletion curves method provides accurate estimates of intrinsic clearance (CLint), maximum velocity of the metabolic reaction (Vmax), and Michaelis constant (Km): accuracy and robustness evaluated through experimental data and Monte Carlo simulations

Ethanol-drug absorption interaction: potential for a significant effect on the plasma pharmacokinetics of ethanol vulnerable formulations

Lennernäs, Hans

Ingår i Molecular pharmaceutics, s. 1429-1440, 2009

• DOI för Ethanol-drug absorption interaction: potential for a significant effect on the plasma pharmacokinetics of ethanol vulnerable formulations

Impact of carriers in oral absorption: Permeation across Caco-2 cells for the organic anions estrone-3-sulfate and glipizide

Gram, Luise K; Rist, Gerda Marie; Lennernäs, Hans; Steffansen, Bente

Ingår i European Journal of Pharmaceutical Sciences, s. 378-386, 2009

• DOI för Impact of carriers in oral absorption: Permeation across Caco-2 cells for the organic anions estrone-3-sulfate and glipizide

Improving glucocorticoid replacement therapy using a novel modified-release hydrocortisone tablet: a pharmacokinetic study

Johannsson, Gudmundur; Bergthorsdottir, Ragnhildur; Nilsson, Anna G; Lennernäs, Hans et al.

Ingår i European Journal of Endocrinology, s. 119-130, 2009

• DOI för Improving glucocorticoid replacement therapy using a novel modified-release hydrocortisone tablet: a pharmacokinetic study

Identification of Finasteride Metabolites in Human Bile and Urine by High-Performance Liquid Chromatography/Tandem Mass Spectrometry

Lundahl, Anna; Lennernäs, Hans; Knutson, Lars; Bondesson, Ulf et al.

Ingår i Drug Metabolism And Disposition, s. 2008-2017, 2009

• DOI för Identification of Finasteride Metabolites in Human Bile and Urine by High-Performance Liquid Chromatography/Tandem Mass Spectrometry

Different effects of ketoconazole on the stereoselective first-pass metabolism of R/S-verapamil in the intestine and the liver: important for the mechanistic understanding of first-pass drug-drug interactions

Thörn, Helena Anna; Hedeland, Mikael; Bondesson, Ulf; Knutson, Lars et al.

Ingår i Drug Metabolism And Disposition, s. 2186-2196, 2009

• DOI för Different effects of ketoconazole on the stereoselective first-pass metabolism of R/S-verapamil in the intestine and the liver: important for the mechanistic understanding of first-pass drug-drug interactions

The Enterohepatic Disposition of Rosuvastatin in Pigs and The Impact of Concomitant Dosing with Cyclosporine and Gemfibrozil

Bergman, Ebba; Lundahl, Anna; Fridblom, Patrik; Hedeland, Mikael et al.

Ingår i Drug Metabolism And Disposition, s. 2349-2358, 2009

• DOI för The Enterohepatic Disposition of Rosuvastatin in Pigs and The Impact of Concomitant Dosing with Cyclosporine and Gemfibrozil

Increased understanding of intestinal drug permeability determined by the LOC-I-GUT approach using multislice computed tomography

Knutson, Tina; Fridblom, Patrik; Ahlström, Håkan; Magnusson, Anders et al.

Ingår i Molecular pharmaceutics, s. 2-10, 2009

• DOI för Increased understanding of intestinal drug permeability determined by the LOC-I-GUT approach using multislice computed tomography

Intestinal and hepatobiliary transport of ximelagatran and its metabolites in pigs

Sjödin, Elin; Fritsch, Holger; Eriksson, Ulf G; Logren, Ulrika et al.

Ingår i Drug Metabolism And Disposition, s. 1519-1528, 2008

• DOI för Intestinal and hepatobiliary transport of ximelagatran and its metabolites in pigs

Improved understanding of the effect of food on drug absorption and bioavailability for lipophilic compounds using an intestinal pig perfusion model

Persson, Eva M.; Nordgren, Anders; Forsell, Patrik; Knutson, Lars et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 22-29, 2008

• DOI för Improved understanding of the effect of food on drug absorption and bioavailability for lipophilic compounds using an intestinal pig perfusion model

The use of BDDCS in classifying the permeability of marketed drugs

Benet, Leslie Z.; Amidon, Gordon L.; Barends, Dirk M.; Lennernäs, Hans et al.

Ingår i Pharmaceutical research, s. 483-488, 2008

• DOI för The use of BDDCS in classifying the permeability of marketed drugs

Is there an effect of food on the biliary secretion of cyclosporine and three in vivo formed metabolites in a porcine model?

Persson, Eva M.; Nordgren, A.; Forsell, P.; Knutson, L. et al.

Ingår i Journal of Drug Delivery Science and Technology, s. 253-258, 2007

Gene and protein expression of P-glycoprotein, MRP1, MRP2 and CYP3A4 in the small and large human intestine

Berggren, Sofia; Gall, Christine; Wollnitz, Nadine; Ekelund, Mats et al.

Ingår i Molecular Pharmaceutics, s. 252-257, 2007

• DOI för Gene and protein expression of P-glycoprotein, MRP1, MRP2 and CYP3A4 in the small and large human intestine

Simultaneous assessment of lipid classes and bile acids in human intestinal fluid by solid-phase extraction and HPLC methods

Persson, Eva; Löfgren, Lars; Hansson, Göran; Abrahamsson, Bertil et al.

Ingår i Journal of Lipid Research, s. 242-251, 2007

• DOI för Simultaneous assessment of lipid classes and bile acids in human intestinal fluid by solid-phase extraction and HPLC methods

Intestinal permeability and its relevance for absorption and elimination

Lennernäs, H

Ingår i Xenobiotica, s. 1015-1051, 2007

• DOI för Intestinal permeability and its relevance for absorption and elimination

Physiologically-based Kinetic Modelling (PBK Modelling): Meeting the 3Rs agenda. The report and recommendations of ECVAM Workshop 63

Bouvier d'Yvoire, Michel; Prieto, Pilar; Blaauboer, Bas; Bois, Frederic et al.

Ingår i ATLA (Alternatives to Laboratory Animals), s. 661-671, 2007

Pharmacokinetics of gefitinib in humans: the influence of gastrointestinal factors

Bergman, Ebba; Forsell, Patrik; Persson, Eva M.; Knutson, Lars et al.

Ingår i International Journal of Pharmaceutics, s. 134-142, 2007

• DOI för Pharmacokinetics of gefitinib in humans: the influence of gastrointestinal factors

Long-acting hydrocortisone for glucocorticoid replacement therapy

Johannsson, Gudmundur; Filipsson, Helena; Bergthorsdottir, Ragnhildur; Lennernäs, Hans et al.

Ingår i Hormone Research, s. 182-188, 2007

• DOI för Long-acting hydrocortisone for glucocorticoid replacement therapy

A clinical single-pass perfusion investigation of the dynamic in vivo secretory response to a dietary meal in human proximal small intestine

Persson, Eva M; Nilsson, Ralf G; Hansson, Göran I; Löfgren, Lars J et al.

Ingår i Pharmaceutical research, s. 742-751, 2006

• DOI för A clinical single-pass perfusion investigation of the dynamic in vivo secretory response to a dietary meal in human proximal small intestine

Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model

Cao, Xianhua; Gibbs, Seth T.; Fang, Lanyan; Miller, Heather A. et al.

Ingår i Pharmaceutical research, s. 1675-1686, 2006

• DOI för Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model

The effect of pancreatic and biliary depletion on the in vivo pharmacokinetics of digoxin in pigs.

Tannergren, Christer; Evilevitch, Lena; Pierzynowski, Stefan; Piedra, Jose Valverde et al.

Ingår i Eur J Pharm Sci, s. 198-204, 2006

Preface.

Langguth, P; Bermejo, M; Lennernäs, H

Ingår i Eur J Pharm Sci, s. 173, 2006

Flutamide metabolism in four different species in vitro and identification of flutamide metabolites in human patient urine by high performance liquid chromatography/tandem mass spectrometry.

Tevell, Annica; Lennernäs, Hans; Jönsson, Mats; Norlin, Maria et al.

Ingår i Drug Metab Dispos, s. 984-92, 2006

Effect of erythromycin on the absorption of fexofenadine in the jejunum, ileum and colon determined using local intubation in healthy volunteers.

Petri, N; Borga, O; Nyberg, L; Hedeland, M et al.

Ingår i Int J Clin Pharmacol Ther, s. 71-9, 2006

Folate absorption from folate-fortified and processed foods using a human ileostomy model.

Witthöft, Cornelia M; Arkbåge, Karin; Johansson, Madelene; Lundin, Eva et al.

Ingår i Br J Nutr, s. 181-7, 2006

First-pass effects of verapamil on the intestinal absorption and liver disposition of fexofenadine in the porcine model.

Petri, Niclas; Bergman, Ebba; Forsell, Patrik; Hedeland, Mikael et al.

Ingår i Drug Metab Dispos, s. 1182-9, 2006

Biliary secretion of rosuvastatin and bile acids in humans during the absorption phase.

Bergman, Ebba; Forsell, Patrik; Tevell, Annica; Persson, Eva M et al.

Ingår i Eur J Pharm Sci, s. 205-14, 2006

Presentation of a structurally diverse and commercially available drug data set for correlation and benchmarking studies.

Skold, Christian; Winiwarter, Susanne; Wernevik, Johan; Bergstrom, Fredrik et al.

Ingår i J Med Chem, s. 6660-71, 2006

The effects of food on the dissolution of poorly soluble drugs in human and in model small intestinal fluids

Persson, Eva M; Gustafsson, Ann-Sofie; Carlsson, Anders S; Nilsson, Ralf G et al.

Ingår i Pharmaceutical research, s. 2141-2151, 2005

• DOI för The effects of food on the dissolution of poorly soluble drugs in human and in model small intestinal fluids

The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension.

Lennernäs, Hans; Abrahamsson, Bertil

Ingår i J Pharm Pharmacol, s. 273-85, 2005

Pharmacokinetics and tolerability of different doses of fentanyl following sublingual administration of a rapidly dissolving tablet to cancer patients: a new approach to treatment of incident pain.

Lennernäs, B; Hedner, T; Holmberg, M; Bredenberg, S et al.

Ingår i Br J Clin Pharmacol, s. 249-53, 2005

EUFEPS conference on drug transporters at Copenhagen: integrative approaches in ADME research.

Meijer, Dirk K F; Lennernäs, Hans

Ingår i Eur J Pharm Sci, s. 130-43, 2005

Transport characteristics of fexofenadine in the Caco-2 cell model

Petri, Niclas; Tannergren, Christer; Rungstad, David; Lennernäs, Hans

Ingår i Pharmaceutical research, s. 1398-1404, 2004

• DOI för Transport characteristics of fexofenadine in the Caco-2 cell model

St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism

Tannergren, Christer; Engman, Helena; Knutson, Lars; Hedeland, Mikael et al.

Ingår i Clinical Pharmacology and Therapeutics, s. 298-309, 2004

• DOI för St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism

Simultaneous quantification of the enantiomers of verapamil and its N-demethylated metabolite in human plasma using liquid chromatography-tandem mass spectrometry

Hedeland, Mikael; Fredriksson, Elisabeth; Lennernäs, Hans; Bondesson, Ulf

Ingår i Journal of chromatography. B, s. 303-311, 2004

• DOI för Simultaneous quantification of the enantiomers of verapamil and its N-demethylated metabolite in human plasma using liquid chromatography-tandem mass spectrometry

Regional intestinal absorption and biliary excretion of fluvastatin in the rat: Possible involvement of mrp2.

Lindahl, A; Sjöberg, Å; Bredberg, U; Ungell, A-L et al.

Ingår i Molecular Pharmaceutics 1, s. 347, 2004

Proposals on the innovation policy by Ostros--correct diagnosis but wrong treatment

Hedner, Thomas; Lennernäs, Hans; Ottosson, Pontus

Ingår i Lakartidningen, s. 2287-8, 2004

Characterization of jejunal absorption and apical efflux of ropivacaine, lidocaine and bupivacaine in the rat using in situ and in vitro absorption models.

Berggren, Sofia; Hoogstraate, Janet; Fagerholm, Urban; Lennernäs, Hans

Ingår i Eur J Pharm Sci, s. 553-60, 2004

Intestinal and blood-brain barrier drug transport: beyond involvement of a single transport function.

Lennernäs, H; Lundgren, E

Ingår i Drug Discovery Today 1, s. 417, 2004

Molecular properties of WHO essential drugs and provisional biopharmaceutical classification.

Kasim, Nehal A; Whitehouse, Marc; Ramachandran, Chandrasekharan; Bermejo, Marival et al.

Ingår i Mol Pharm, s. 85-96, 2004

Drug transporters: Where is the research taking us?

Lennernäs, H

Ingår i Eur J Pharm Sci, 2004

Optimizing levodopa pharmacokinetics: intestinal infusion versus oral sustained-release tablets

Nyholm, Dag; Askmark, Håkan; Gomes-Trolin, Cecilia; Knutson, Tina et al.

Ingår i Clinical neuropharmacology, s. 156-163, 2003

Expression of genes encoding for drug metabolising cytochrome P450 enzymes and P-glycoprotein in the rat small intestine: comparison to the liver

Lindell, Monica; Lang, Matti; Lennernäs, Hans

Ingår i Eur. J. Drug Metab. & Pharmacokin., s. 41-48, 2003

Multiple transport mechanisms involved in the intestinal absorption and first-pass extraction of fexofenadine.

Tannergren, Christer; Petri, Niclas; Knutson, Lars; Hedeland, Mikael et al.

Ingår i Clin Pharmacol Ther, s. 423-36, 2003

Levodopa pharmacokinetics and motor performance during activities of daily living in patients with Parkinson's disease on individual drug combinations

Nyholm, Dag; Lennernäs, Hans; Gomes-Trolin, Cecilia; Aquilonius, Sten-Magnus

Ingår i Clinical neuropharmacology, s. 89-96, 2002

• DOI för Levodopa pharmacokinetics and motor performance during activities of daily living in patients with Parkinson's disease on individual drug combinations

Effects of cholesterol and model transmembrane proteins on drugpartitioning into lipid bilayers as analysed by immobilized-liposomechromatography.

Lagerquist, C; Beigi, F; Karlen, A; Lennernas, H et al.

Ingår i J Pharm Pharmacol, s. 1477, 2001

Absorption of L-DOPA from the proximal small intestine studied in the rhesus monkey by positron emission tomography

Nilsson, Dag; Lennernäs, Hans; Fasth, Karl Johan; Sundin, Anders et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 185-189, 1999

• DOI för Absorption of L-DOPA from the proximal small intestine studied in the rhesus monkey by positron emission tomography

Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

Ingår i European journal of pharmaceutics and biopharmaceutics

Review on the effect of chemotherapy on the intestinal barrier: Epithelial permeability, mucus and bacterial translocation

Dahlgren, David; Lennernäs, Hans

Ingår i Biomedicine and Pharmacotherapy, 2023

• DOI för Review on the effect of chemotherapy on the intestinal barrier: Epithelial permeability, mucus and bacterial translocation
• Ladda ner fulltext (pdf) av Review on the effect of chemotherapy on the intestinal barrier: Epithelial permeability, mucus and bacterial translocation

Application of In Vivo Imaging Techniques and Diagnostic Tools in Oral Drug Delivery Research

Senekowitsch, Stefan; Schick, Philipp; Abrahamsson, Bertil; Augustijns, Patrick et al.

Ingår i Pharmaceutics, 2022

• DOI för Application of In Vivo Imaging Techniques and Diagnostic Tools in Oral Drug Delivery Research
• Ladda ner fulltext (pdf) av Application of In Vivo Imaging Techniques and Diagnostic Tools in Oral Drug Delivery Research

Best practices in current models mimicking drug permeability in the gastrointestinal tract - An UNGAP review

O'Shea, Joseph P.; Augustijns, Patrick; Brandl, Martin; Brayden, David J. et al.

Ingår i European Journal of Pharmaceutical Sciences, 2022

• DOI för Best practices in current models mimicking drug permeability in the gastrointestinal tract - An UNGAP review
• Ladda ner fulltext (pdf) av Best practices in current models mimicking drug permeability in the gastrointestinal tract - An UNGAP review

Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies

Dahlgren, David; Sjöblom, Markus; Hellström, Per M.; Lennernäs, Hans

Ingår i Frontiers in Pharmacology, 2021

• DOI för Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies
• Ladda ner fulltext (pdf) av Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies

Limitations and Possibilities of Transarterial Chemotherapeutic Treatment of Hepatocellular Carcinoma

Ebeling Barbier, Charlotte; Heindryckx, Femke; Lennernäs, Hans

Ingår i International Journal of Molecular Sciences, 2021

• DOI för Limitations and Possibilities of Transarterial Chemotherapeutic Treatment of Hepatocellular Carcinoma
• Ladda ner fulltext (pdf) av Limitations and Possibilities of Transarterial Chemotherapeutic Treatment of Hepatocellular Carcinoma

Leveraging Oral Drug Development to a Next Level: Impact of the IMI-Funded OrBiTo Project on Patient Healthcare

Hens, Bart; Augustijns, Patrick; Lennernäs, Hans; McAllister, Mark et al.

Ingår i Frontiers in Medicine, 2021

• DOI för Leveraging Oral Drug Development to a Next Level: Impact of the IMI-Funded OrBiTo Project on Patient Healthcare
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Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective

Dahlgren, David; Lennernäs, Hans

Ingår i Molecules, 2020

• DOI för Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective
• Ladda ner fulltext (pdf) av Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective

The Critical Role of Passive Permeability in Designing Successful Drugs

Di, Li; Artursson, Per; Avdeef, Alex; Benet, Leslie Z. et al.

Ingår i ChemMedChem, s. 1862-1874, 2020

• DOI för The Critical Role of Passive Permeability in Designing Successful Drugs

Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models

Dahlgren, David; Sjögren, Erik; Lennernäs, Hans

Ingår i ADMET & DMPK, s. 375-390, 2020

• DOI för Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models
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Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches

Dahlgren, David; Lennernäs, Hans

Ingår i Pharmaceutics, 2019

• DOI för Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches
• Ladda ner fulltext (pdf) av Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches

Formulation predictive dissolution (fPD) testing to advance oral drug product development: An introduction to the US FDA funded '21st Century BA/BE' project

Hens, Bart; Sinko, Patrick D.; Job, Nicholas; Dean, Meagan et al.

Ingår i International Journal of Pharmaceutics, s. 120-127, 2018

• DOI för Formulation predictive dissolution (fPD) testing to advance oral drug product development: An introduction to the US FDA funded '21st Century BA/BE' project

Direct In Vivo Human Intestinal Permeability (P-eff) Determined with Different Clinical Perfusion and Intubation Methods

Dahlgren, David; Roos, Carl; Sjögren, Erik; Lennernäs, Hans

Ingår i Journal of Pharmaceutical Sciences, s. 2702-2726, 2015

• DOI för Direct In Vivo Human Intestinal Permeability (P-eff) Determined with Different Clinical Perfusion and Intubation Methods

Adrenal insufficiency: review of clinical outcomes with current glucocorticoid replacement therapy

Johannsson, Gudmundur; Falorni, Alberto; Skrtic, Stanko; Lennernäs, Hans et al.

Ingår i Clinical Endocrinology, s. 2-11, 2015

• DOI för Adrenal insufficiency: review of clinical outcomes with current glucocorticoid replacement therapy

Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition

Smith, Dennis; Artursson, Per; Avdeef, Alex; Di, Li et al.

Ingår i Molecular Pharmaceutics, s. 1727-1738, 2014

• DOI för Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition

Improving outcomes in patients with adrenal insufficiency: a review of current and future treatments

Johannsson, Gudmundur; Skrtic, Stanko; Lennernäs, Hans; Quinkler, Marcus et al.

Ingår i Current Medical Research and Opinion, s. 1833-1847, 2014

• DOI för Improving outcomes in patients with adrenal insufficiency: a review of current and future treatments

Regional intestinal drug permeation: Biopharmaceutics and drug development

Lennernas, Hans

Ingår i European Journal of Pharmaceutical Sciences, s. 333-341, 2014

• DOI för Regional intestinal drug permeation: Biopharmaceutics and drug development

Oral biopharmaceutics tools - Time for a new initiative - An introduction to the IMI project OrBiTo

Lennernäs, Hans; Aarons, L.; Augustijns, P.; Beato, S. et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 292-299, 2014

• DOI för Oral biopharmaceutics tools - Time for a new initiative - An introduction to the IMI project OrBiTo

Human in Vivo Regional Intestinal Permeability: Importance for Pharmaceutical Drug Development

Lennernäs, Hans

Ingår i Molecular Pharmaceutics, s. 12-23, 2014

• DOI för Human in Vivo Regional Intestinal Permeability: Importance for Pharmaceutical Drug Development

Complexity of Motor Response to Different Doses of Duodenal Levodopa Infusion in Parkinson Disease

Nyholm, Dag; Johansson, Anders; Aquilonius, Sten-Magnus; Hellquist, Elisabeth et al.

Ingår i Clinical neuropharmacology, s. 6-14, 2012

• DOI för Complexity of Motor Response to Different Doses of Duodenal Levodopa Infusion in Parkinson Disease

Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

Di, Li; Artursson, Per; Avdeef, Alex; Ecker, Gerhard F. et al.

Ingår i Drug Discovery Today, s. 905-912, 2012

• DOI för Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

Replacement therapy of oral hydrocortisone in adrenal insufficiency: the influence of gastrointestinal factors

Lennernäs, Hans; Skrtic, Stanko; Johannsson, Gudmundur

Ingår i Expert Opinion on Drug Metabolism and Toxicology, s. 749-758, 2008

• DOI för Replacement therapy of oral hydrocortisone in adrenal insufficiency: the influence of gastrointestinal factors

Irregular gastrointestinal drug absorption in Parkinson's disease

Nyholm, Dag; Lennernäs, Hans

Ingår i Expert Opinion on Drug Metabolism and Toxicology, s. 193-203, 2008

• DOI för Irregular gastrointestinal drug absorption in Parkinson's disease

Animal data: The contributions of the Ussing Chamber and perfusion systems to predicting human oral drug delivery in vivo

Lennernäs, Hans

Ingår i Advanced Drug Delivery Reviews, s. 1103-1120, 2007

• DOI för Animal data: The contributions of the Ussing Chamber and perfusion systems to predicting human oral drug delivery in vivo

Modeling gastrointestinal drug absorption requires more in vivo biopharmaceutical data: experience from in vivo dissolution and permeability studies in humans

Lennernäs, Hans

Ingår i Current drug metabolism, s. 645-657, 2007

Oral drug absorption and the biopharmaceutics classification system

Lennernäs, Hans; Abrahamsson, Bertil; Persson, EM; Knutson, Lars

Ingår i Journal of drug delivery science and technology, s. 237-244, 2007

The biopharmaceutical classification system

Lennernäs, H; Abrahamsson, B

Ingår i Comprehensive medicinal chemistry, Elsevier, 2006

Pharmacological inhibition of PERK during early carcinogenesis restrains tumor progression and remodels the tumor microenvironment in hepatocellular carcinoma

Khaled, Jaafar; Kopsida, Maria; Payo Serafín, Tania; Sennefelt Nyman, Sofi et al.

Characterization of hepatocellular carcinoma patient-derived organoids receiving transarterial chemoembolization as a preclinical model for drug response assessment

Khaled, Jaafar; Sennefelt Nyman, Sofi; Rorsman, Fredrik; Lennernäs, Hans et al.

Tumor microenvironment–driven response to anthracyclines in different in vitro models for hepatocellular carcinoma

Lerma Clavero, Ada; Kopsida, Maria; Heras, Unai; Mitxelena-Iribarren, Oihane et al.

Pharmacokinetics and safety profile of idarubicin-lipiodol chemoembolization of hepatocellular carcinoma

Dahlgren, David; Sennefelt Nyman, Sofi; Niessen, Janis; Dimopoulou, Angeliki et al.

Imaging-assessed tumor aggressiveness is associated with response to Transarterial chemoembolization in Hepatocellular carcinoma patients

Sennefelt Nyman, Sofi; Westin, Anna; Ingelhammar, Fritiof; Ahlström, Håkan et al.