Novel In Vitro Models for Subcutaneous Administration of Drugs (Completed project)
Developing an in vitro model capable of predicting in vivo behaviour of subcutaneous injection.
Research scientist: Agnes Rodler, PhD
Principal Investigator: Professor Per Hansson, Department of Medicinal Chemistry, Uppsala University
Scientific and industrial context. In drug delivery, the subcutaneous route increasingly supersedes the oral and intravenous routes of drug administration. Contrary to the latter two ways of delivery, there is lack of standardised in vitro model for robust prediction of in vivo absorption and bioavailability of drugs administered subcutaneously.
Aim. By developing a physiologically relevant model of the extracellular matrix we have improved the mechanistic understanding of subcutaneous injection to facilitate the innovation and development of formulations with high bioavailability of the active pharmaceutical ingredient and small variability between patients.
This model targets to identify biophysical factors which affect molecular transport through the interstitial space and to elucidate to which extent drug-extracellular matrix interactions are size- or charge related.
Outcome. An in vitro model capable of predicting in vivo behaviour of subcutaneous injection.