Jan Dumanski – Molekylär onkologi

The overarching aim of our research is to understand the fundamental principles underlying the occurrence of post-zygotic mutations (somatic mosaicism) and their impact on human health. In particular, we are focused on the loss of chromosome Y (LOY), a phenomenon that arises mainly in the white blood cells of elderly men.

We work with translational disease-related projects and with questions addressing the consequences of somatic variation in normal human cells. With an emphasis on structural genetic variation, which is known as a dominating type of human inter-individual variation.

  • Our specific projects are:
  • Mosaic loss of chromosome Y (LOY) in blood cells is associated with more severe COVID-19, as well as higher mortality, risk for cancer and Alzheimer’s disease in men.
  • Post-zygotic genetic variation: studies of human aging/longevity and age-associated aberrations
  • Novel bio-markers for breast cancer; disease prediction and progression

Read more about or research projects

Group members

Research leader: Jan Dumanski

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