Tobias Sjöblom – Finding and understanding cancer-causing molecular alterations

Our research focuses on molecular changes that are associated with cancer. The aim is to find and develop ways to use measurable molecular information for diagnosis and treatment for cancer.

We utilise molecular biology, databases and clinical data as well as patient samples, cell lines and other tumour models to learn more about cancer development and how to detect and combat tumours effectively. Most of our work concerns colorectal cancer but we also study other types of cancer in some of our projects.
Our main areas of interest are:

Identification of cancer-specific mutations and other aberrations in cancer cells.
Investigation of how specific mutations contribute to tumour development or metastasis.
Development of anti-cancer treatment that targets specific genetic properties of cancer cells.
Identification of blood-borne biomolecules that are linked to occurrence of cancer.
Development of methods to aid or improve diagnosis.

Ongoing research includes e.g. identification and functional studies of genetic aberrations in colorectal cancers, development of a novel cancer treatment and identification of biomarkers to enable blood-based cancer diagnostics tests.

Photo: Mikael Wallerstedt

Spin-out companies

Our research has previously resulted in spin-out companies to enable implementation of research results in health care. Oncodia AB develops CE/IVD approved software and reagent kits for application in clinical genomics that guides treatment selection.

U-CAN – samples and data for cancer research

Translational cancer research is dependent on access to high quality patient samples and Tobias Sjöblom is Director of the U-CAN project, where clinical samples and information are collected from cancer patients for the purpose of supporting high quality research.

Read more about our projects

Read more about U-CAN

Publications

Albacarcin V adds EPLIN as a novel and promising target for the treatment of female cancers and pediatric medulloblastoma

Krahulcova, Lucia; Lindell, Emma; Lu, Xi; Conejeros Monsalve, Jessica Javiera et al.

Part of Biochemical Pharmacology, 2026
- DOI for Albacarcin V adds EPLIN as a novel and promising target for the treatment of female cancers and pediatric medulloblastoma
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A human pan-disease blood atlas of the circulating proteome

Álvez, María Bueno; Bergström, Sofia; Kenrick, Josefin; Johansson, Emil et al.

Part of Science, 2025
- DOI for A human pan-disease blood atlas of the circulating proteome
A novel PML germline variant as a candidate predisposing genetic aberration in familial acute myeloid leukaemia.

Soussi, Thierry; Kundu, Snehangshu; Gerbaud, Pauline; Pandzic, Tatjana et al.

Part of British Journal of Haematology, p. 1118-1121, 2025
- DOI for A novel PML germline variant as a candidate predisposing genetic aberration in familial acute myeloid leukaemia.
Identification of a small molecule targeting EPLIN as a novel strategy for the treatment of pediatric neuroblastoma and medulloblastoma

Lindell, Emma; Guo, Jing; Zhao, Miao; Rameika, Natallia et al.

Part of Cell Death and Disease, 2025
- DOI for Identification of a small molecule targeting EPLIN as a novel strategy for the treatment of pediatric neuroblastoma and medulloblastoma
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KRAS and NRAS mutations in Nordic population-based and real-world metastatic colorectal cancer cohorts

Österlund, Emerik; Ristimäki, Ari; Nunes, Luís; Kytölä, Soili et al.

Part of BJC REPORTS, 2025
- DOI for KRAS and NRAS mutations in Nordic population-based and real-world metastatic colorectal cancer cohorts
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Molecular classification of microsatellite-instable colorectal cancers reveals distinct predictors of immunotherapy response

Lin, C.; Luo, T.; Wu, M.; Li, F. et al.

Part of ESMO GASTROINTESTINAL ONCOLOGY, 2025
- DOI for Molecular classification of microsatellite-instable colorectal cancers reveals distinct predictors of immunotherapy response
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NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors

Rameika, Natallia; Tsiara, Ioanna; Zhang, Xiaonan; Haberek, Wawrzyniec et al.

Part of Biochimica et Biophysica Acta - Molecular Basis of Disease, 2025
- DOI for NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors
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Precision Omics Initiative Sweden (PROMISE) will integrate research with healthcare

Kampe, Anders; Gudmundsson, Sanna; Walsh, Colum P.; Lindblad-Toh, Kerstin et al.

Part of Nature Medicine, p. 1730-1732, 2025
- DOI for Precision Omics Initiative Sweden (PROMISE) will integrate research with healthcare
Primary tumour location, molecular alterations, treatments, and outcome in a population-based metastatic colorectal cancer cohort

Österlund, Emerik; Hammarström, Klara; Nunes, Luís; Mathot, Lucy et al.

Part of BJC REPORTS, 2025
- DOI for Primary tumour location, molecular alterations, treatments, and outcome in a population-based metastatic colorectal cancer cohort
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scFFPE-ATAC enables high-throughput single cell chromatin accessibility profiling in formalin-fixed paraffin-embedded samples

Yadav, Ram Prakash; Xing, Pengwei; Zhao, Miao; Hollander, Peter et al.

Part of Nature Communications, 2025
- DOI for scFFPE-ATAC enables high-throughput single cell chromatin accessibility profiling in formalin-fixed paraffin-embedded samples
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Tissue-resident microbiota impacts colorectal cancer progression and prognosis

Shi, Zhun; Ren, Huahui; Lin, Cong; Li, Fuqiang et al.

Part of Nature Communications, p. 346, 2025
- DOI for Tissue-resident microbiota impacts colorectal cancer progression and prognosis
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Atypical (non‐V600E) BRAF mutations in metastatic colorectal cancer in population and real‐world cohorts

Österlund, Emerik; Ristimäki, Ari; Mäkinen, Markus J.; Kytölä, Soili et al.

Part of International Journal of Cancer, p. 488-503, 2024
- DOI for Atypical (non‐V600E) BRAF mutations in metastatic colorectal cancer in population and real‐world cohorts
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Clinical and genetic factors associated with tumor response to neoadjuvant (chemo)radiotherapy, survival and recurrence risk in rectal cancer

Hammarström, Klara; Nunes, Luís; Mathot, Lucy; Mezheyeuski, Artur et al.

Part of International Journal of Cancer, p. 40-53, 2024
- DOI for Clinical and genetic factors associated with tumor response to neoadjuvant (chemo)radiotherapy, survival and recurrence risk in rectal cancer
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Co-occurring mutations identify prognostic subgroups of microsatellite stable colorectal cancer

Nunes, Luís; Mørkved Stenersen, Jakob; Kryeziu, Kushtrim; Sjöblom, Tobias et al.

Part of Molecular Cancer, 2024
- DOI for Co-occurring mutations identify prognostic subgroups of microsatellite stable colorectal cancer
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Enhanced classification performance using deep learning based segmentation for pulmonary embolism detection in CT angiography.

Kahraman, Ali Teymur; Fröding, Tomas; Toumpanakis, Dimitrios; Jamtheim Gustafsson, Christian et al.

Part of Heliyon, 2024
- DOI for Enhanced classification performance using deep learning based segmentation for pulmonary embolism detection in CT angiography.
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Evaluation of coverage, generalisability and validity of the U-CAN lymphoma biobank in Sweden: A comparison with nationwide registers

Forsgren, Elin; Ekberg, Sara; Smedby, Karin E.; Nylund, Patrick et al.

Part of British Journal of Haematology, p. 1794-1803, 2024
- DOI for Evaluation of coverage, generalisability and validity of the U-CAN lymphoma biobank in Sweden: A comparison with nationwide registers
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Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib

Zhang, Xiaonan; Rameika, Natallia; Zhong, Lei; Veanes, Margus et al.

Part of EBioMedicine, 2024
- DOI for Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib
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Prognostic genome and transcriptome signatures in colorectal cancers

Nunes, Luís; Li, Fuqiang; Wu, Meizhen; Luo, Tian et al.

Part of Nature, p. 137-146, 2024
- DOI for Prognostic genome and transcriptome signatures in colorectal cancers
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Sensitive and Specific Analyses of Colorectal Cancer Recurrence through Multiplex superRCA Mutation Detection in Blood Plasma

Sandberg, Emma; Nunes, Luís; Edqvist, Per-Henrik; Mathot, Lucy et al.

Part of Cancers, 2024
- DOI for Sensitive and Specific Analyses of Colorectal Cancer Recurrence through Multiplex superRCA Mutation Detection in Blood Plasma
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An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers

Mezheyeuski, Artur; Backman, Max; Mattsson, Johanna Sofia Margareta; Martin-Bernabe, Alfonso et al.

Part of EBioMedicine, 2023
- DOI for An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers
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Automated detection, segmentation and measurement of major vessels and the trachea in CT pulmonary angiography

Kahraman, Ali T.; Fröding, Tomas; Toumpanakis, Dimitrios; Sladoje, Nataša et al.

Part of Scientific Reports, 2023
- DOI for Automated detection, segmentation and measurement of major vessels and the trachea in CT pulmonary angiography
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Exact Probability Distribution for the ROC Area under Curve

Ekström, Joakim; Åkerrén Ögren, Jim; Sjöblom, Tobias

Part of Cancers, 2023
- DOI for Exact Probability Distribution for the ROC Area under Curve
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Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells

Lu, Xi; Zhong, Lei; Lindell, Emma; Veanes, Margus et al.

Part of Cell Death and Disease, 2023
- DOI for Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells
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Next generation pan-cancer blood proteome profiling using proximity extension assay

Alvez, Maria Bueno; Edfors, Fredrik; von Feilitzen, Kalle; Zwahlen, Martin et al.

Part of Nature Communications, 2023
- DOI for Next generation pan-cancer blood proteome profiling using proximity extension assay
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Recurring EPHB1 mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cells

Kundu, Snehangshu; Nunes, Luís; Adler, Jeremy; Mathot, Lucy et al.

Part of Cell Communication and Signaling, 2023
- DOI for Recurring EPHB1 mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cells
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Signet Ring Cell Colorectal and Appendiceal Cancer: A Small Signet Ring Cell Component Is Also Associated with Poor Outcome

Enblad, Malin; Pál Egerszegi, Péter; Birgisson, Helgi; Sjöblom, Tobias et al.

Part of Cancers, 2023
- DOI for Signet Ring Cell Colorectal and Appendiceal Cancer: A Small Signet Ring Cell Component Is Also Associated with Poor Outcome
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Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity

Zhang, Xiaonan; Akcan, Ece; Correia, Mario S. P.; Rameika, Natallia et al.

Part of Biochemical Pharmacology, 2022
- DOI for Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity
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Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions

Westergren Jakobsson, Amanda; Kundu, Snehangshu; Guo, Jing; Chowdhury, Azazul Islam et al.

Part of Cancers, 2022
- DOI for Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions
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KRAS-G12C Mutation in One Real-Life and Three Population-Based Nordic Cohorts of Metastatic Colorectal Cancer

Österlund, Emerik; Ristimaki, Ari; Kytola, Soili; Kuopio, Teijo et al.

Part of Frontiers in Oncology, 2022
- DOI for KRAS-G12C Mutation in One Real-Life and Three Population-Based Nordic Cohorts of Metastatic Colorectal Cancer
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Next Generation Plasma Proteomics Identifies High-Precision Biomarker Candidates for Ovarian Cancer.

Gyllensten, Ulf B.; Hedlund-Lindberg, Julia; Svensson, Johanna; Manninen, Johanna et al.

Part of Cancers, 2022
- DOI for Next Generation Plasma Proteomics Identifies High-Precision Biomarker Candidates for Ovarian Cancer.
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Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples

Zhang, Hua; Polavarapu, Vamsi Krishna; Xing, Pengwei; Zhao, Miao et al.

Part of Genome Research, p. 150-161, 2022
- DOI for Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples
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A Comprehensive Evaluation of Associations Between Routinely Collected Staging Information and The Response to (Chemo)Radiotherapy in Rectal Cancer

Hammarström, Klara; Imam, Israa; Mezheyeuski, Artur; Ekström, Joakim et al.

Part of Cancers, 2021
- DOI for A Comprehensive Evaluation of Associations Between Routinely Collected Staging Information and The Response to (Chemo)Radiotherapy in Rectal Cancer
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Accurate population-based model for individual prediction of colon cancer recurrence

Osterman, Erik; Ekström, Joakim; Sjöblom, Tobias; Kørner, Hartwig et al.

Part of Acta Oncologica, p. 1241-1249, 2021
- DOI for Accurate population-based model for individual prediction of colon cancer recurrence
Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis

Kundu, Snehangshu; Ali, Muhammad Akhtar; Handin, Niklas; Conway, Louis P. et al.

Part of Journal of Experimental & Clinical Cancer Research, 2021
- DOI for Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis
- Download full text (pdf) of Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis
Completeness and accuracy of the registration of recurrences in the Swedish Colorectal Cancer Registry (SCRCR) and an update of recurrence risk in colon cancer

Osterman, Erik; Hammarström, Klara; Imam, Israa; Österlund, Emerik et al.

Part of Acta Oncologica, p. 842-849, 2021
- DOI for Completeness and accuracy of the registration of recurrences in the Swedish Colorectal Cancer Registry (SCRCR) and an update of recurrence risk in colon cancer
FACT-seq: profiling histone modifications in formalin-fixed paraffin-embedded samples with low cell numbers

Zhao, Linxuan; Xing, Pengwei; Polavarapu, Vamsi Krishna; Zhao, Miao et al.

Part of Nucleic Acids Research, 2021
- DOI for FACT-seq: profiling histone modifications in formalin-fixed paraffin-embedded samples with low cell numbers
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Neoadjuvant rectal (NAR) score: Value evaluating the efficacy of neoadjuvant therapy and prognostic significance after surgery?

Imam, Israa; Hammarström, Klara; Sjöblom, Tobias; Glimelius, Bengt

Part of Radiotherapy and Oncology, p. 70-77, 2021
- DOI for Neoadjuvant rectal (NAR) score: Value evaluating the efficacy of neoadjuvant therapy and prognostic significance after surgery?
- Download full text (pdf) of Neoadjuvant rectal (NAR) score: Value evaluating the efficacy of neoadjuvant therapy and prognostic significance after surgery?
Targeting Loss of Heterozygosity: A Novel Paradigm for Cancer Therapy

Zhang, Xiaonan; Sjöblom, Tobias

Part of Pharmaceuticals, 2021
- DOI for Targeting Loss of Heterozygosity: A Novel Paradigm for Cancer Therapy
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The Immune Landscape of Colorectal Cancer

Mezheyeuski, Artur; Micke, Patrick; Martin-Bernabe, Alfonso; Backman, Max et al.

Part of Cancers, 2021
- DOI for The Immune Landscape of Colorectal Cancer
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Beyond the NCCN Risk Factors in Colon Cancer: An Evaluation in a Swedish Population-Based Cohort

Osterman, Erik; Mezheyeuski, Artur; Sjöblom, Tobias; Glimelius, Bengt

Part of Annals of Surgical Oncology, p. 1036-1045, 2020
- DOI for Beyond the NCCN Risk Factors in Colon Cancer: An Evaluation in a Swedish Population-Based Cohort
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Defining eligible patients for allele-selective chemotherapies targeting NAT2 in colorectal cancer

Rendo, Verónica; Kundu, Snehangshu; Rameika, Natallia; Ljungström, Viktor et al.

Part of Scientific Reports, 2020
- DOI for Defining eligible patients for allele-selective chemotherapies targeting NAT2 in colorectal cancer
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Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Rendo, Verónica; Stoimenov, Ivaylo; Mateus, André; Sjöberg, Elin et al.

Part of Nature Communications, 2020
- DOI for Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy
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Molecular characterization of a large unselected cohort of metastatic colorectal cancers in relation to primary tumor location, rare metastatic sites and prognosis

Nunes, Luís; Aasebø, Kristine; Mathot, Lucy; Ljungström, Viktor et al.

Part of Acta Oncologica, p. 417-426, 2020
- DOI for Molecular characterization of a large unselected cohort of metastatic colorectal cancers in relation to primary tumor location, rare metastatic sites and prognosis
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Prognostic Interactions between FAP plus Fibroblasts and CD8a+T Cells in Colon Cancer

Herrera, Mercedes; Mezheyeuski, Artur; Villabona, Lisa; Corvigno, Sara et al.

Part of Cancers, 2020
- DOI for Prognostic Interactions between FAP plus Fibroblasts and CD8a+T Cells in Colon Cancer
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Recurrence Risk after Radical Colorectal Cancer Surgery: Less Than before, But How High Is It?

Osterman, Erik; Hammarström, Klara; Imam, Israa; Österlund, Emerik et al.

Part of Cancers, 2020
- DOI for Recurrence Risk after Radical Colorectal Cancer Surgery: Less Than before, But How High Is It?
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Restoration of KMT2C/MLL3 in human colorectal cancer cells reinforces genome-wide H3K4me1 profiles and influences cell growth and gene expression

Larsson, Chatarina; Cordeddu, Lina; Siggens, Lee; Djureinovic, Tatjana et al.

Part of Clinical Epigenetics, 2020
- DOI for Restoration of KMT2C/MLL3 in human colorectal cancer cells reinforces genome-wide H3K4me1 profiles and influences cell growth and gene expression
- Download full text (pdf) of Restoration of KMT2C/MLL3 in human colorectal cancer cells reinforces genome-wide H3K4me1 profiles and influences cell growth and gene expression
Targeted sequencing reveals the somatic mutation landscape in a Swedish breast cancer cohort

Mathioudaki, Argyri; Ljungström, Viktor; Melin, Malin; Arendt, Maja Louise et al.

Part of Scientific Reports, 2020
- DOI for Targeted sequencing reveals the somatic mutation landscape in a Swedish breast cancer cohort
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Targeting tumor vulnerabilities associated with loss of heterozygosity

Rendo, Veronica; Stoimenov, Ivaylo; Sjöblom, Tobias

Part of Molecular & Cellular Oncology, 2020
- DOI for Targeting tumor vulnerabilities associated with loss of heterozygosity
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Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2

Conway, Louis P.; Rendo, Verónica; Correia, Mario S. P.; Bergdahl, Ingvar A et al.

Part of Angewandte Chemie International Edition, p. 14342-14346, 2020
- DOI for Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2
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Agreement between molecular subtyping and surrogate subtype classification: a contemporary population-based study of ER-positive/HER2-negative primary breast cancer

Lundgren, Christine; Bendahl, Pär-Ola; Borg, Åke; Ehinger, Anna et al.

Part of Breast Cancer Research and Treatment, p. 459-467, 2019
- DOI for Agreement between molecular subtyping and surrogate subtype classification: a contemporary population-based study of ER-positive/HER2-negative primary breast cancer
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Cross comparison and prognostic assessment of breast cancer multigene signatures in a large population-based contemporary clinical series

Vallon-Christersson, Johan; Häkkinen, Jari; Hegardt, Cecilia; Saal, Lao H. et al.

Part of Scientific Reports, 2019
- DOI for Cross comparison and prognostic assessment of breast cancer multigene signatures in a large population-based contemporary clinical series
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Determining the use of preoperative (chemo)radiotherapy in primary rectal cancer according to national and international guidelines

Hammarström, Klara; Imam, Israa; Korsavidou Hult, Nafsika; Ekström, Joakim et al.

Part of Radiotherapy and Oncology, p. 106-112, 2019
- DOI for Determining the use of preoperative (chemo)radiotherapy in primary rectal cancer according to national and international guidelines
Stroma-normalised vessel density predicts benefit from adjuvant fluorouracil-based chemotherapy in patients with stage II/III colon cancer

Mezheyeuski, Artur; Hrynchyk, Ina; Herrera, Mercedes; Karlberg, Mia et al.

Part of British Journal of Cancer, p. 303-311, 2019
- DOI for Stroma-normalised vessel density predicts benefit from adjuvant fluorouracil-based chemotherapy in patients with stage II/III colon cancer
Digital multiplex immunofluorescence analysis identifies immune profiles in the tumor stroma associated with clinical outcome

Mezheyeuski, Artur; Bergsland, Christian; Backman, Max; Sjöblom, Tobias et al.

Part of CANCER IMMUNOLOGY RESEARCH, 2018
- DOI for Digital multiplex immunofluorescence analysis identifies immune profiles in the tumor stroma associated with clinical outcome
Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells

Kundu, Snehangshu; Ali, Muhammad Akhtar; Handin, Niklas; Padhan, Narendra et al.

Part of Genome Medicine, 2018
- DOI for Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells
Multispectral imaging for quantitative and compartment-specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients

Mezheyeuski, Artur; Bergsland, Christian Holst; Backman, Max; Djureinovic, Dijana et al.

Part of Journal of Pathology, p. 421-431, 2018
- DOI for Multispectral imaging for quantitative and compartment-specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients
Stage distribution utilizing magnetic resonance imaging in an unselected population of primary rectal cancers

Hammarström, Klara; Mezheyeuski, Artur; Korsavidou Hult, Nafsika; Sjöblom, Tobias et al.

Part of European Journal of Surgical Oncology, p. 1858-1864, 2018
- DOI for Stage distribution utilizing magnetic resonance imaging in an unselected population of primary rectal cancers
U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden.

Glimelius, Bengt; Melin, Beatrice; Enblad, Gunilla; Alafuzoff, Irina et al.

Part of Acta Oncologica, p. 187-194, 2018
- DOI for U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden.
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VEGF receptor-2/neuropilin 1 trans-complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival

Morin, Eric; Sjöberg, Elin; Tjomsland, Vegard; Testini, Chiara et al.

Part of Journal of Pathology, p. 311-322, 2018
- DOI for VEGF receptor-2/neuropilin 1 trans-complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival
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A new distance measure for non-identical data with application to image classification

Swaminathan, Muthukaruppan; Yadav, Pankaj Kumar; Piloto, Obdulio; Sjöblom, Tobias et al.

Part of Pattern Recognition, p. 384-396, 2017
- DOI for A new distance measure for non-identical data with application to image classification
A pathology atlas of the human cancer transcriptome

Uhlen, Mathias; Zhang, Cheng; Lee, Sunjae; Sjöstedt, Evelina et al.

Part of Science, 2017
- DOI for A pathology atlas of the human cancer transcriptome
Loss of DIP2C in RKO cells stimulates changes in DNA methylation and epithelial-mesenchymal transition

Larsson, Chatarina; Ali, Muhammad Akhtar; Djureinovic, Tatjana; Lindroth, Anders M. et al.

Part of BMC Cancer, 2017
- DOI for Loss of DIP2C in RKO cells stimulates changes in DNA methylation and epithelial-mesenchymal transition
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Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity

Karlsson, Henning; Fryknäs, Mårten; Strese, Sara; Gullbo, Joachim et al.

Part of Oncotarget, p. 30217-30234, 2017
- DOI for Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity
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Mutanome engineered RNA immuno-therapy (MERIT) for patients with triple negative breast cancer

Frenzel, K.; Heesen, L.; Bolte, S.; Bukur, V. et al.

Part of Annals of Oncology, 2017
- DOI for Mutanome engineered RNA immuno-therapy (MERIT) for patients with triple negative breast cancer
Somatic Ephrin Receptor Mutations Are Associated with Metastasis in Primary Colorectal Cancer

Mathot, Lucy; Kundu, Snehangshu; Ljungström, Viktor; Svedlund, Jessica et al.

Part of Cancer Research, p. 1730-1740, 2017
- DOI for Somatic Ephrin Receptor Mutations Are Associated with Metastasis in Primary Colorectal Cancer
Somatic PRDM2 c.4467delA mutations in colorectal cancers control histone methylation and tumor growth

Pandzic, Tatjana; Rendo, Verónica; Lim, Jinyeong; Larsson, Chatarina et al.

Part of Oncotarget, p. 98646-98659, 2017
- DOI for Somatic PRDM2 c.4467delA mutations in colorectal cancers control histone methylation and tumor growth
Targeted DNA sequencing and in situ mutation analysis using mobile phone microscopy

Kühnemund, Malte; Wei, Qingshan; Darai, Evangelia; Wang, Yingjie et al.

Part of Nature Communications, 2017
- DOI for Targeted DNA sequencing and in situ mutation analysis using mobile phone microscopy
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Transposon Mutagenesis Reveals Fludarabine Resistance Mechanisms in Chronic Lymphocytic Leukemia

Pandzic, Tatjana; Larsson, Jimmy; He, Liqun; Kundu, Snehangshu et al.

Part of Clinical Cancer Research, p. 6217-6227, 2016
- DOI for Transposon Mutagenesis Reveals Fludarabine Resistance Mechanisms in Chronic Lymphocytic Leukemia
Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations

Ljungström, Viktor; Cortese, Diego; Young, Emma; Pandzic, Tatjana et al.

Part of Blood, p. 1007-1016, 2016
- DOI for Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations
Computational and molecular tools for scalable rAAV-mediated genome editing

Stoimenov, Ivaylo; Ali, Muhammad Akhtar; Pandzic, Tatjana; Sjöblom, Tobias

Part of Nucleic Acids Research, 2015
- DOI for Computational and molecular tools for scalable rAAV-mediated genome editing
DISSECTING RESISTANCE MECHANISMS IN CHRONIC LYMPHOCYTIC LEUKEMIA USING WHOLE-EXOME SEQUENCING: IMPACT OF RECURRENT RPS15 MUTATIONS ON P53 DYSREGULATION

Ljungström, Viktor; Cortese, Diego; Young, Emma; Pandzic, Tatjana et al.

Part of Haematologica, p. 10-11, 2015
Mutanome Engineered RNA Immunotherapy (MERIT)

Sahin, Ugur; Zitvogel, Laurence; Andre, Fabrice; Thielemans, Kris et al.

Part of HUMAN GENE THERAPY CLINICAL DEVELOPMENT, p. 84-86, 2015
- DOI for Mutanome Engineered RNA Immunotherapy (MERIT)
The Mutanome Engineered RNA Immuno-Therapy (MERIT) project

Heesch, Sandra; Britten, Cedrik M.; Bukur, Valesca; Buck, Janina et al.

Part of Cancer Research, 2015
- DOI for The Mutanome Engineered RNA Immuno-Therapy (MERIT) project
Transcriptional modulator ZBED6 affects cell cycle and growth of human colorectal cancer cells

Ali, Muhammad Akhtar; Younis, Shady; Wallerman, Ola; Gupta, Rajesh et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 7743-7748, 2015
- DOI for Transcriptional modulator ZBED6 affects cell cycle and growth of human colorectal cancer cells
Tumor Vessel Up-Regulation of INSR Revealed by Single-Cell Expression Analysis of the Tyrosine Kinome and Phosphatome in Human Cancers

Kiflemariam, Sara; Ljungström, Viktor; Pontén, Fredrik; Sjöblom, Tobias

Part of American Journal of Pathology, p. 1600-1609, 2015
- DOI for Tumor Vessel Up-Regulation of INSR Revealed by Single-Cell Expression Analysis of the Tyrosine Kinome and Phosphatome in Human Cancers
1p36 deletion is a marker for tumour dissemination in microsatellite stable stage II-III colon cancer

Mayrhofer, Markus; Kultima, Hanna Göransson; Birgisson, Helgi; Sundström, Magnus et al.

Part of BMC Cancer, p. 872, 2014
- DOI for 1p36 deletion is a marker for tumour dissemination in microsatellite stable stage II-III colon cancer
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A Pragmatic Definition of Therapeutic Synergy Suitable for Clinically Relevant In Vitro Multicompound Analyses

Kashif, Muhammad; Andersson, Claes; Åberg, Magnus; Nygren, Peter et al.

Part of Molecular Cancer Therapeutics, p. 1964-1976, 2014
- DOI for A Pragmatic Definition of Therapeutic Synergy Suitable for Clinically Relevant In Vitro Multicompound Analyses
In situ sequencing identifies TMPRSS2-ERG fusion transcripts, somatic point mutations and gene expression levels in prostate cancers

Kiflemariam, Sara; Mignardi, Marco; Ali, Muhammad Akhtar; Bergh, Anders et al.

Part of Journal of Pathology, p. 253-261, 2014
- DOI for In situ sequencing identifies TMPRSS2-ERG fusion transcripts, somatic point mutations and gene expression levels in prostate cancers
Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15

Bruzzese, Francesca; Hagglof, Christina; Leone, Alessandra; Sjoberg, Elin et al.

Part of Cancer Research, p. 3408-3417, 2014
- DOI for Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15
Automated serial extraction of DNA and RNA from biobanked tissue specimens

Mathot, Lucy; Wallin, Monica; Sjöblom, Tobias

Part of BMC Biotechnology, p. 66, 2013
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Gene rearrangements in hormone receptor negative breast cancers revealed by mate pair sequencing

Jiao, Xiang; Hooper, Sean D.; Djureinovic, Tatjana; Larsson, Chatarina et al.

Part of BMC Genomics, 2013
- DOI for Gene rearrangements in hormone receptor negative breast cancers revealed by mate pair sequencing
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In situ mutation detection and visualization of intratumor heterogeneity for cancer research and diagnostics

Grundberg, Ida; Kiflemariam, Sara; Mignardi, Marco; Imgenberg-Kreuz, Juliana et al.

Part of Oncotarget, p. 2407-2418, 2013
STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer

Pena, Cristina; Virtudes Cespedes, Maria; Lindh, Maja Bradic; Kiflemariam, Sara et al.

Part of Cancer Research, p. 1287-1297, 2013
- DOI for STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer
Validation of a yeast functional assay for p53 mutations using clonal sequencing

Iggo, Richard; Rudewicz, Justine; Monceau, Elodie; Sevenet, Nicolas et al.

Part of Journal of Pathology, p. 441-448, 2013
- DOI for Validation of a yeast functional assay for p53 mutations using clonal sequencing
Automated Genotyping of Biobank Samples by Multiplex Amplification of Insertion/Deletion Polymorphisms

Mathot, Lucy; Falk Sörqvist, Elin; Moens, Lotte; Allen, Marie et al.

Part of PLOS ONE, 2012
- DOI for Automated Genotyping of Biobank Samples by Multiplex Amplification of Insertion/Deletion Polymorphisms
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Core Ras Pathway Signaling in Human Colorectal Cancers Revealed by Isogenic Modeling of NF1, KRAS and BRAF Mutations

Ali, Muhammad Akhtar; Sjöblom, Tobias

Part of European Journal of Cancer, 2012
- DOI for Core Ras Pathway Signaling in Human Colorectal Cancers Revealed by Isogenic Modeling of NF1, KRAS and BRAF Mutations
Direct Detection of TMPRSS2-ERG Rearrangements in Prostate Cancer by Padlock Probes

Kiflemariam, Sara; Mignardi, M.; Bergh, A.; Nilsson, M. et al.

Part of European Journal of Cancer, 2012
- DOI for Direct Detection of TMPRSS2-ERG Rearrangements in Prostate Cancer by Padlock Probes
Scalable In Situ Hybridization on Tissue Arrays for Validation of Novel Cancer and Tissue-Specific Biomarkers

Kiflemariam, Sara; Andersson, Sandra; Asplund, Anna; Pontén, Fredrik et al.

Part of PLOS ONE, 2012
- DOI for Scalable In Situ Hybridization on Tissue Arrays for Validation of Novel Cancer and Tissue-Specific Biomarkers
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Somatic mutations in the notch, NF-KB, PIK3CA, and hedgehog pathways in human breast cancers

Jiao, Xiang; Wood, Laura D.; Lindman, Monica; Jones, Sian et al.

Part of Genes, Chromosomes and Cancer, p. 480-489, 2012
- DOI for Somatic mutations in the notch, NF-KB, PIK3CA, and hedgehog pathways in human breast cancers
The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy

Hernlund, Emma; Olofsson, Maria Hägg; Fayad, Walid; Fryknäs, Mårten et al.

Part of European Journal of Cancer, p. 396-406, 2012
- DOI for The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy
Common pathogenetic mechanism involving human chromosome 18 in familial and sporadic ileal carcinoid tumors

Cunningham, Janet L.; Díaz de Ståhl, Teresita; Sjöblom, Tobias; Westin, Gunnar et al.

Part of Genes, Chromosomes and Cancer, p. 82-94, 2011
- DOI for Common pathogenetic mechanism involving human chromosome 18 in familial and sporadic ileal carcinoid tumors
Structural Alterations from Multiple Displacement Amplification of a Human Genome Revealed by Mate-Pair Sequencing

Jiao, Xiang; Rosenlund, Magnus; Hooper, Sean D.; Tellgren-Roth, Christian et al.

Part of PLOS ONE, 2011
- DOI for Structural Alterations from Multiple Displacement Amplification of a Human Genome Revealed by Mate-Pair Sequencing
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Targeted resequencing of candidate genes using Selector Probes

Johansson, Henrik; Isaksson, Magnus; Sörqvist, Elin Falk; Roos, F. et al.

Part of Nucleic Acids Research, 2011
- DOI for Targeted resequencing of candidate genes using Selector Probes
Efficient and scalable serial extraction of DNA and RNA from frozen tissue samples

Mathot, Lucy; Lindman, Monica; Sjöblom, Tobias

Part of Chemical Communications, p. 547-549, 2010
- DOI for Efficient and scalable serial extraction of DNA and RNA from frozen tissue samples
Molecular pathways in tumor progression: from discovery to functional understanding

Ali, Muhammad Akhtar; Sjöblom, Tobias

Part of Molecular bioSystems, p. 902-908, 2009
- DOI for Molecular pathways in tumor progression: from discovery to functional understanding
Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer

Paulsson, Janna; Sjöblom, Tobias; Micke, Patrick; Pontén, Fredrik et al.

Part of American Journal of Pathology, p. 334-341, 2009
- DOI for Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer
Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis

Gal, Annamaria; Sjöblom, Tobias; Fedorova, L.; Imreh, S. et al.

Part of Oncogene, p. 1218-1230, 2008
- DOI for Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis
Systematic analyses of the cancer genome: Lessons learned from sequencing most of the annotated human protein-coding genes

Sjöblom, Tobias

Part of Current Opinion in Oncology, p. 66-71, 2008
- DOI for Systematic analyses of the cancer genome: Lessons learned from sequencing most of the annotated human protein-coding genes
A multidimensional analysis of genes mutated in breast and colorectal cancers

Lin, Jimmy; Gan, Christine M; Zhang, Xiaosong; Jones, Siân et al.

Part of Genome Research, p. 1304-1318, 2007
- DOI for A multidimensional analysis of genes mutated in breast and colorectal cancers
In situ detection of phosphorylated platelet-derived growth factor receptor beta using a generalized proximity ligation method

Jarvius, Malin; Paulsson, Janna; Weibrecht, Irene; Leuchowius, Karl-Johan et al.

Part of Molecular & Cellular Proteomics, p. 1500-1509, 2007
- DOI for In situ detection of phosphorylated platelet-derived growth factor receptor beta using a generalized proximity ligation method

Part of research areas

Cancer Precision Medicine