Tobias Sjöblom – Karaktärisering av molekylära förändringar i cancer

NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors

Rameika, Natallia; Tsiara, Ioanna; Zhang, Xiaonan; Haberek, Wawrzyniec et al.

Ingår i Biochimica et Biophysica Acta - Molecular Basis of Disease, 2025

• DOI för NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors
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Atypical (non‐V600E) BRAF mutations in metastatic colorectal cancer in population and real‐world cohorts

Österlund, Emerik; Ristimäki, Ari; Mäkinen, Markus J.; Kytölä, Soili et al.

Ingår i International Journal of Cancer, s. 488-503, 2024

• DOI för Atypical (non‐V600E) BRAF mutations in metastatic colorectal cancer in population and real‐world cohorts
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Clinical and genetic factors associated with tumor response to neoadjuvant (chemo)radiotherapy, survival and recurrence risk in rectal cancer

Hammarström, Klara; Nunes, Luís; Mathot, Lucy; Mezheyeuski, Artur et al.

Ingår i International Journal of Cancer, s. 40-53, 2024

• DOI för Clinical and genetic factors associated with tumor response to neoadjuvant (chemo)radiotherapy, survival and recurrence risk in rectal cancer
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Co-occurring mutations identify prognostic subgroups of microsatellite stable colorectal cancer

Nunes, Luís; Mørkved Stenersen, Jakob; Kryeziu, Kushtrim; Sjöblom, Tobias et al.

Ingår i Molecular Cancer, 2024

• DOI för Co-occurring mutations identify prognostic subgroups of microsatellite stable colorectal cancer
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Enhanced classification performance using deep learning based segmentation for pulmonary embolism detection in CT angiography.

Kahraman, Ali Teymur; Fröding, Tomas; Toumpanakis, Dimitrios; Jamtheim Gustafsson, Christian et al.

Ingår i Heliyon, 2024

• DOI för Enhanced classification performance using deep learning based segmentation for pulmonary embolism detection in CT angiography.
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Evaluation of coverage, generalisability and validity of the U-CAN lymphoma biobank in Sweden: A comparison with nationwide registers

Forsgren, Elin; Ekberg, Sara; Smedby, Karin E.; Nylund, Patrick et al.

Ingår i British Journal of Haematology, s. 1794-1803, 2024

• DOI för Evaluation of coverage, generalisability and validity of the U-CAN lymphoma biobank in Sweden: A comparison with nationwide registers
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Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib

Zhang, Xiaonan; Rameika, Natallia; Zhong, Lei; Veanes, Margus et al.

Ingår i EBioMedicine, 2024

• DOI för Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib
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Prognostic genome and transcriptome signatures in colorectal cancers

Nunes, Luís; Li, Fuqiang; Wu, Meizhen; Luo, Tian et al.

Ingår i Nature, s. 137-146, 2024

• DOI för Prognostic genome and transcriptome signatures in colorectal cancers

Sensitive and Specific Analyses of Colorectal Cancer Recurrence through Multiplex superRCA Mutation Detection in Blood Plasma

Sandberg, Emma; Nunes, Luís; Edqvist, Per-Henrik; Mathot, Lucy et al.

Ingår i Cancers, 2024

• DOI för Sensitive and Specific Analyses of Colorectal Cancer Recurrence through Multiplex superRCA Mutation Detection in Blood Plasma
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An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers

Mezheyeuski, Artur; Backman, Max; Mattsson, Johanna Sofia Margareta; Martin-Bernabe, Alfonso et al.

Ingår i EBioMedicine, 2023

• DOI för An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers
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Automated detection, segmentation and measurement of major vessels and the trachea in CT pulmonary angiography

Kahraman, Ali T.; Fröding, Tomas; Toumpanakis, Dimitrios; Sladoje, Nataša et al.

Ingår i Scientific Reports, 2023

• DOI för Automated detection, segmentation and measurement of major vessels and the trachea in CT pulmonary angiography
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Exact Probability Distribution for the ROC Area under Curve

Ekström, Joakim; Åkerrén Ögren, Jim; Sjöblom, Tobias

Ingår i Cancers, 2023

• DOI för Exact Probability Distribution for the ROC Area under Curve
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Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells

Lu, Xi; Zhong, Lei; Lindell, Emma; Veanes, Margus et al.

Ingår i Cell Death and Disease, 2023

• DOI för Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells
• Ladda ner fulltext (pdf) av Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells

Next generation pan-cancer blood proteome profiling using proximity extension assay

Alvez, Maria Bueno; Edfors, Fredrik; von Feilitzen, Kalle; Zwahlen, Martin et al.

Ingår i Nature Communications, 2023

• DOI för Next generation pan-cancer blood proteome profiling using proximity extension assay
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Recurring EPHB1 mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cells

Kundu, Snehangshu; Nunes, Luís; Adler, Jeremy; Mathot, Lucy et al.

Ingår i Cell Communication and Signaling, 2023

• DOI för Recurring EPHB1 mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cells
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Signet Ring Cell Colorectal and Appendiceal Cancer: A Small Signet Ring Cell Component Is Also Associated with Poor Outcome

Enblad, Malin; Pál Egerszegi, Péter; Birgisson, Helgi; Sjöblom, Tobias et al.

Ingår i Cancers, 2023

• DOI för Signet Ring Cell Colorectal and Appendiceal Cancer: A Small Signet Ring Cell Component Is Also Associated with Poor Outcome
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Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity

Zhang, Xiaonan; Akcan, Ece; Correia, Mario S. P.; Rameika, Natallia et al.

Ingår i Biochemical Pharmacology, 2022

• DOI för Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity
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Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions

Westergren Jakobsson, Amanda; Kundu, Snehangshu; Guo, Jing; Chowdhury, Azazul Islam et al.

Ingår i Cancers, 2022

• DOI för Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions
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KRAS-G12C Mutation in One Real-Life and Three Population-Based Nordic Cohorts of Metastatic Colorectal Cancer

Österlund, Emerik; Ristimaki, Ari; Kytola, Soili; Kuopio, Teijo et al.

Ingår i Frontiers in Oncology, 2022

• DOI för KRAS-G12C Mutation in One Real-Life and Three Population-Based Nordic Cohorts of Metastatic Colorectal Cancer
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Next Generation Plasma Proteomics Identifies High-Precision Biomarker Candidates for Ovarian Cancer.

Gyllensten, Ulf B.; Hedlund-Lindberg, Julia; Svensson, Johanna; Manninen, Johanna et al.

Ingår i Cancers, 2022

• DOI för Next Generation Plasma Proteomics Identifies High-Precision Biomarker Candidates for Ovarian Cancer.
• Ladda ner fulltext (pdf) av Next Generation Plasma Proteomics Identifies High-Precision Biomarker Candidates for Ovarian Cancer.

Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples

Zhang, Hua; Polavarapu, Vamsi Krishna; Xing, Pengwei; Zhao, Miao et al.

Ingår i Genome Research, s. 150-161, 2022

• DOI för Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples
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A Comprehensive Evaluation of Associations Between Routinely Collected Staging Information and The Response to (Chemo)Radiotherapy in Rectal Cancer

Hammarström, Klara; Imam, Israa; Mezheyeuski, Artur; Ekström, Joakim et al.

Ingår i Cancers, 2021

• DOI för A Comprehensive Evaluation of Associations Between Routinely Collected Staging Information and The Response to (Chemo)Radiotherapy in Rectal Cancer
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Accurate population-based model for individual prediction of colon cancer recurrence

Osterman, Erik; Ekström, Joakim; Sjöblom, Tobias; Kørner, Hartwig et al.

Ingår i Acta Oncologica, s. 1241-1249, 2021

• DOI för Accurate population-based model for individual prediction of colon cancer recurrence

Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis

Kundu, Snehangshu; Ali, Muhammad Akhtar; Handin, Niklas; Conway, Louis P. et al.

Ingår i Journal of Experimental & Clinical Cancer Research, 2021

• DOI för Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis
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Completeness and accuracy of the registration of recurrences in the Swedish Colorectal Cancer Registry (SCRCR) and an update of recurrence risk in colon cancer

Osterman, Erik; Hammarström, Klara; Imam, Israa; Österlund, Emerik et al.

Ingår i Acta Oncologica, s. 842-849, 2021

• DOI för Completeness and accuracy of the registration of recurrences in the Swedish Colorectal Cancer Registry (SCRCR) and an update of recurrence risk in colon cancer

FACT-seq: profiling histone modifications in formalin-fixed paraffin-embedded samples with low cell numbers

Zhao, Linxuan; Xing, Pengwei; Polavarapu, Vamsi Krishna; Zhao, Miao et al.

Ingår i Nucleic Acids Research, 2021

• DOI för FACT-seq: profiling histone modifications in formalin-fixed paraffin-embedded samples with low cell numbers
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Neoadjuvant rectal (NAR) score: Value evaluating the efficacy of neoadjuvant therapy and prognostic significance after surgery?

Imam, Israa; Hammarström, Klara; Sjöblom, Tobias; Glimelius, Bengt

Ingår i Radiotherapy and Oncology, s. 70-77, 2021

• DOI för Neoadjuvant rectal (NAR) score: Value evaluating the efficacy of neoadjuvant therapy and prognostic significance after surgery?
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Targeting Loss of Heterozygosity: A Novel Paradigm for Cancer Therapy

Zhang, Xiaonan; Sjöblom, Tobias

Ingår i Pharmaceuticals, 2021

• DOI för Targeting Loss of Heterozygosity: A Novel Paradigm for Cancer Therapy
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The Immune Landscape of Colorectal Cancer

Mezheyeuski, Artur; Micke, Patrick; Martin-Bernabe, Alfonso; Backman, Max et al.

Ingår i Cancers, 2021

• DOI för The Immune Landscape of Colorectal Cancer
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Beyond the NCCN Risk Factors in Colon Cancer: An Evaluation in a Swedish Population-Based Cohort

Osterman, Erik; Mezheyeuski, Artur; Sjöblom, Tobias; Glimelius, Bengt

Ingår i Annals of Surgical Oncology, s. 1036-1045, 2020

• DOI för Beyond the NCCN Risk Factors in Colon Cancer: An Evaluation in a Swedish Population-Based Cohort
• Ladda ner fulltext (pdf) av Beyond the NCCN Risk Factors in Colon Cancer: An Evaluation in a Swedish Population-Based Cohort

Defining eligible patients for allele-selective chemotherapies targeting NAT2 in colorectal cancer

Rendo, Verónica; Kundu, Snehangshu; Rameika, Natallia; Ljungström, Viktor et al.

Ingår i Scientific Reports, 2020

• DOI för Defining eligible patients for allele-selective chemotherapies targeting NAT2 in colorectal cancer
• Ladda ner fulltext (pdf) av Defining eligible patients for allele-selective chemotherapies targeting NAT2 in colorectal cancer

Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Rendo, Verónica; Stoimenov, Ivaylo; Mateus, André; Sjöberg, Elin et al.

Ingår i Nature Communications, 2020

• DOI för Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy
• Ladda ner fulltext (pdf) av Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Molecular characterization of a large unselected cohort of metastatic colorectal cancers in relation to primary tumor location, rare metastatic sites and prognosis

Nunes, Luís; Aasebø, Kristine; Mathot, Lucy; Ljungström, Viktor et al.

Ingår i Acta Oncologica, s. 417-426, 2020

• DOI för Molecular characterization of a large unselected cohort of metastatic colorectal cancers in relation to primary tumor location, rare metastatic sites and prognosis
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Prognostic Interactions between FAP plus Fibroblasts and CD8a+T Cells in Colon Cancer

Herrera, Mercedes; Mezheyeuski, Artur; Villabona, Lisa; Corvigno, Sara et al.

Ingår i Cancers, 2020

• DOI för Prognostic Interactions between FAP plus Fibroblasts and CD8a+T Cells in Colon Cancer
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Recurrence Risk after Radical Colorectal Cancer Surgery: Less Than before, But How High Is It?

Osterman, Erik; Hammarström, Klara; Imam, Israa; Österlund, Emerik et al.

Ingår i Cancers, 2020

• DOI för Recurrence Risk after Radical Colorectal Cancer Surgery: Less Than before, But How High Is It?
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Restoration of KMT2C/MLL3 in human colorectal cancer cells reinforces genome-wide H3K4me1 profiles and influences cell growth and gene expression

Larsson, Chatarina; Cordeddu, Lina; Siggens, Lee; Djureinovic, Tatjana et al.

Ingår i Clinical Epigenetics, 2020

• DOI för Restoration of KMT2C/MLL3 in human colorectal cancer cells reinforces genome-wide H3K4me1 profiles and influences cell growth and gene expression
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Targeted sequencing reveals the somatic mutation landscape in a Swedish breast cancer cohort

Mathioudaki, Argyri; Ljungström, Viktor; Melin, Malin; Arendt, Maja Louise et al.

Ingår i Scientific Reports, 2020

• DOI för Targeted sequencing reveals the somatic mutation landscape in a Swedish breast cancer cohort
• Ladda ner fulltext (pdf) av Targeted sequencing reveals the somatic mutation landscape in a Swedish breast cancer cohort

Targeting tumor vulnerabilities associated with loss of heterozygosity

Rendo, Veronica; Stoimenov, Ivaylo; Sjöblom, Tobias

Ingår i Molecular & Cellular Oncology, 2020

• DOI för Targeting tumor vulnerabilities associated with loss of heterozygosity
• Ladda ner fulltext (pdf) av Targeting tumor vulnerabilities associated with loss of heterozygosity

Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2

Conway, Louis P.; Rendo, Verónica; Correia, Mario S. P.; Bergdahl, Ingvar A et al.

Ingår i Angewandte Chemie International Edition, s. 14342-14346, 2020

• DOI för Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2
• Ladda ner fulltext (pdf) av Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2

Agreement between molecular subtyping and surrogate subtype classification: a contemporary population-based study of ER-positive/HER2-negative primary breast cancer

Lundgren, Christine; Bendahl, Pär-Ola; Borg, Åke; Ehinger, Anna et al.

Ingår i Breast Cancer Research and Treatment, s. 459-467, 2019

• DOI för Agreement between molecular subtyping and surrogate subtype classification: a contemporary population-based study of ER-positive/HER2-negative primary breast cancer
• Ladda ner fulltext (pdf) av Agreement between molecular subtyping and surrogate subtype classification: a contemporary population-based study of ER-positive/HER2-negative primary breast cancer

Cross comparison and prognostic assessment of breast cancer multigene signatures in a large population-based contemporary clinical series

Vallon-Christersson, Johan; Häkkinen, Jari; Hegardt, Cecilia; Saal, Lao H. et al.

Ingår i Scientific Reports, 2019

• DOI för Cross comparison and prognostic assessment of breast cancer multigene signatures in a large population-based contemporary clinical series
• Ladda ner fulltext (pdf) av Cross comparison and prognostic assessment of breast cancer multigene signatures in a large population-based contemporary clinical series

Determining the use of preoperative (chemo)radiotherapy in primary rectal cancer according to national and international guidelines

Hammarström, Klara; Imam, Israa; Korsavidou Hult, Nafsika; Ekström, Joakim et al.

Ingår i Radiotherapy and Oncology, s. 106-112, 2019

• DOI för Determining the use of preoperative (chemo)radiotherapy in primary rectal cancer according to national and international guidelines

Stroma-normalised vessel density predicts benefit from adjuvant fluorouracil-based chemotherapy in patients with stage II/III colon cancer

Mezheyeuski, Artur; Hrynchyk, Ina; Herrera, Mercedes; Karlberg, Mia et al.

Ingår i British Journal of Cancer, s. 303-311, 2019

• DOI för Stroma-normalised vessel density predicts benefit from adjuvant fluorouracil-based chemotherapy in patients with stage II/III colon cancer

Digital multiplex immunofluorescence analysis identifies immune profiles in the tumor stroma associated with clinical outcome

Mezheyeuski, Artur; Bergsland, Christian; Backman, Max; Sjöblom, Tobias et al.

Ingår i CANCER IMMUNOLOGY RESEARCH, 2018

• DOI för Digital multiplex immunofluorescence analysis identifies immune profiles in the tumor stroma associated with clinical outcome

Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells

Kundu, Snehangshu; Ali, Muhammad Akhtar; Handin, Niklas; Padhan, Narendra et al.

Ingår i Genome Medicine, 2018

• DOI för Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells

Multispectral imaging for quantitative and compartment-specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients

Mezheyeuski, Artur; Bergsland, Christian Holst; Backman, Max; Djureinovic, Dijana et al.

Ingår i Journal of Pathology, s. 421-431, 2018

• DOI för Multispectral imaging for quantitative and compartment-specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients

Stage distribution utilizing magnetic resonance imaging in an unselected population of primary rectal cancers

Hammarström, Klara; Mezheyeuski, Artur; Korsavidou Hult, Nafsika; Sjöblom, Tobias et al.

Ingår i European Journal of Surgical Oncology, s. 1858-1864, 2018

• DOI för Stage distribution utilizing magnetic resonance imaging in an unselected population of primary rectal cancers

U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden.

Glimelius, Bengt; Melin, Beatrice; Enblad, Gunilla; Alafuzoff, Irina et al.

Ingår i Acta Oncologica, s. 187-194, 2018

• DOI för U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden.
• Ladda ner fulltext (pdf) av U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden.

VEGF receptor-2/neuropilin 1 trans-complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival

Morin, Eric; Sjöberg, Elin; Tjomsland, Vegard; Testini, Chiara et al.

Ingår i Journal of Pathology, s. 311-322, 2018

• DOI för VEGF receptor-2/neuropilin 1 trans-complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival
• Ladda ner fulltext (pdf) av VEGF receptor-2/neuropilin 1 trans-complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival

A new distance measure for non-identical data with application to image classification

Swaminathan, Muthukaruppan; Yadav, Pankaj Kumar; Piloto, Obdulio; Sjöblom, Tobias et al.

Ingår i Pattern Recognition, s. 384-396, 2017

• DOI för A new distance measure for non-identical data with application to image classification

A pathology atlas of the human cancer transcriptome

Uhlen, Mathias; Zhang, Cheng; Lee, Sunjae; Sjöstedt, Evelina et al.

Ingår i Science, 2017

• DOI för A pathology atlas of the human cancer transcriptome

Loss of DIP2C in RKO cells stimulates changes in DNA methylation and epithelial-mesenchymal transition

Larsson, Chatarina; Ali, Muhammad Akhtar; Djureinovic, Tatjana; Lindroth, Anders M. et al.

Ingår i BMC Cancer, 2017

• DOI för Loss of DIP2C in RKO cells stimulates changes in DNA methylation and epithelial-mesenchymal transition
• Ladda ner fulltext (pdf) av Loss of DIP2C in RKO cells stimulates changes in DNA methylation and epithelial-mesenchymal transition

Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity

Karlsson, Henning; Fryknäs, Mårten; Strese, Sara; Gullbo, Joachim et al.

Ingår i Oncotarget, s. 30217-30234, 2017

• DOI för Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity
• Ladda ner fulltext (pdf) av Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity

Mutanome engineered RNA immuno-therapy (MERIT) for patients with triple negative breast cancer

Frenzel, K.; Heesen, L.; Bolte, S.; Bukur, V. et al.

Ingår i Annals of Oncology, 2017

• DOI för Mutanome engineered RNA immuno-therapy (MERIT) for patients with triple negative breast cancer

Somatic Ephrin Receptor Mutations Are Associated with Metastasis in Primary Colorectal Cancer

Mathot, Lucy; Kundu, Snehangshu; Ljungström, Viktor; Svedlund, Jessica et al.

Ingår i Cancer Research, s. 1730-1740, 2017

• DOI för Somatic Ephrin Receptor Mutations Are Associated with Metastasis in Primary Colorectal Cancer

Somatic PRDM2 c.4467delA mutations in colorectal cancers control histone methylation and tumor growth

Pandzic, Tatjana; Rendo, Verónica; Lim, Jinyeong; Larsson, Chatarina et al.

Ingår i Oncotarget, s. 98646-98659, 2017

• DOI för Somatic PRDM2 c.4467delA mutations in colorectal cancers control histone methylation and tumor growth

Targeted DNA sequencing and in situ mutation analysis using mobile phone microscopy

Kühnemund, Malte; Wei, Qingshan; Darai, Evangelia; Wang, Yingjie et al.

Ingår i Nature Communications, 2017

• DOI för Targeted DNA sequencing and in situ mutation analysis using mobile phone microscopy
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Transposon Mutagenesis Reveals Fludarabine Resistance Mechanisms in Chronic Lymphocytic Leukemia

Pandzic, Tatjana; Larsson, Jimmy; He, Liqun; Kundu, Snehangshu et al.

Ingår i Clinical Cancer Research, s. 6217-6227, 2016

• DOI för Transposon Mutagenesis Reveals Fludarabine Resistance Mechanisms in Chronic Lymphocytic Leukemia

Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations

Ljungström, Viktor; Cortese, Diego; Young, Emma; Pandzic, Tatjana et al.

Ingår i Blood, s. 1007-1016, 2016

• DOI för Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations

Computational and molecular tools for scalable rAAV-mediated genome editing

Stoimenov, Ivaylo; Ali, Muhammad Akhtar; Pandzic, Tatjana; Sjöblom, Tobias

Ingår i Nucleic Acids Research, 2015

• DOI för Computational and molecular tools for scalable rAAV-mediated genome editing

DISSECTING RESISTANCE MECHANISMS IN CHRONIC LYMPHOCYTIC LEUKEMIA USING WHOLE-EXOME SEQUENCING: IMPACT OF RECURRENT RPS15 MUTATIONS ON P53 DYSREGULATION

Ljungström, Viktor; Cortese, Diego; Young, Emma; Pandzic, Tatjana et al.

Ingår i Haematologica, s. 10-11, 2015

Mutanome Engineered RNA Immunotherapy (MERIT)

Sahin, Ugur; Zitvogel, Laurence; Andre, Fabrice; Thielemans, Kris et al.

Ingår i HUMAN GENE THERAPY CLINICAL DEVELOPMENT, s. 84-86, 2015

• DOI för Mutanome Engineered RNA Immunotherapy (MERIT)

The Mutanome Engineered RNA Immuno-Therapy (MERIT) project

Heesch, Sandra; Britten, Cedrik M.; Bukur, Valesca; Buck, Janina et al.

Ingår i Cancer Research, 2015

• DOI för The Mutanome Engineered RNA Immuno-Therapy (MERIT) project

Transcriptional modulator ZBED6 affects cell cycle and growth of human colorectal cancer cells

Ali, Muhammad Akhtar; Younis, Shady; Wallerman, Ola; Gupta, Rajesh et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 7743-7748, 2015

• DOI för Transcriptional modulator ZBED6 affects cell cycle and growth of human colorectal cancer cells

Tumor Vessel Up-Regulation of INSR Revealed by Single-Cell Expression Analysis of the Tyrosine Kinome and Phosphatome in Human Cancers

Kiflemariam, Sara; Ljungström, Viktor; Pontén, Fredrik; Sjöblom, Tobias

Ingår i American Journal of Pathology, s. 1600-1609, 2015

• DOI för Tumor Vessel Up-Regulation of INSR Revealed by Single-Cell Expression Analysis of the Tyrosine Kinome and Phosphatome in Human Cancers

1p36 deletion is a marker for tumour dissemination in microsatellite stable stage II-III colon cancer

Mayrhofer, Markus; Kultima, Hanna Göransson; Birgisson, Helgi; Sundström, Magnus et al.

Ingår i BMC Cancer, s. 872, 2014

• DOI för 1p36 deletion is a marker for tumour dissemination in microsatellite stable stage II-III colon cancer
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A Pragmatic Definition of Therapeutic Synergy Suitable for Clinically Relevant In Vitro Multicompound Analyses

Kashif, Muhammad; Andersson, Claes; Åberg, Magnus; Nygren, Peter et al.

Ingår i Molecular Cancer Therapeutics, s. 1964-1976, 2014

• DOI för A Pragmatic Definition of Therapeutic Synergy Suitable for Clinically Relevant In Vitro Multicompound Analyses

In situ sequencing identifies TMPRSS2-ERG fusion transcripts, somatic point mutations and gene expression levels in prostate cancers

Kiflemariam, Sara; Mignardi, Marco; Ali, Muhammad Akhtar; Bergh, Anders et al.

Ingår i Journal of Pathology, s. 253-261, 2014

• DOI för In situ sequencing identifies TMPRSS2-ERG fusion transcripts, somatic point mutations and gene expression levels in prostate cancers

Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15

Bruzzese, Francesca; Hagglof, Christina; Leone, Alessandra; Sjoberg, Elin et al.

Ingår i Cancer Research, s. 3408-3417, 2014

• DOI för Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15

Automated serial extraction of DNA and RNA from biobanked tissue specimens

Mathot, Lucy; Wallin, Monica; Sjöblom, Tobias

Ingår i BMC Biotechnology, s. 66, 2013

• DOI för Automated serial extraction of DNA and RNA from biobanked tissue specimens
• Ladda ner fulltext (pdf) av Automated serial extraction of DNA and RNA from biobanked tissue specimens

Gene rearrangements in hormone receptor negative breast cancers revealed by mate pair sequencing

Jiao, Xiang; Hooper, Sean D.; Djureinovic, Tatjana; Larsson, Chatarina et al.

Ingår i BMC Genomics, 2013

• DOI för Gene rearrangements in hormone receptor negative breast cancers revealed by mate pair sequencing
• Ladda ner fulltext (pdf) av Gene rearrangements in hormone receptor negative breast cancers revealed by mate pair sequencing

In situ mutation detection and visualization of intratumor heterogeneity for cancer research and diagnostics

Grundberg, Ida; Kiflemariam, Sara; Mignardi, Marco; Imgenberg-Kreuz, Juliana et al.

Ingår i Oncotarget, s. 2407-2418, 2013

STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer

Pena, Cristina; Virtudes Cespedes, Maria; Lindh, Maja Bradic; Kiflemariam, Sara et al.

Ingår i Cancer Research, s. 1287-1297, 2013

• DOI för STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer

Validation of a yeast functional assay for p53 mutations using clonal sequencing

Iggo, Richard; Rudewicz, Justine; Monceau, Elodie; Sevenet, Nicolas et al.

Ingår i Journal of Pathology, s. 441-448, 2013

• DOI för Validation of a yeast functional assay for p53 mutations using clonal sequencing

Automated Genotyping of Biobank Samples by Multiplex Amplification of Insertion/Deletion Polymorphisms

Mathot, Lucy; Falk Sörqvist, Elin; Moens, Lotte; Allen, Marie et al.

Ingår i PLOS ONE, 2012

• DOI för Automated Genotyping of Biobank Samples by Multiplex Amplification of Insertion/Deletion Polymorphisms
• Ladda ner fulltext (pdf) av Automated Genotyping of Biobank Samples by Multiplex Amplification of Insertion/Deletion Polymorphisms

Core Ras Pathway Signaling in Human Colorectal Cancers Revealed by Isogenic Modeling of NF1, KRAS and BRAF Mutations

Ali, Muhammad Akhtar; Sjöblom, Tobias

Ingår i European Journal of Cancer, 2012

• DOI för Core Ras Pathway Signaling in Human Colorectal Cancers Revealed by Isogenic Modeling of NF1, KRAS and BRAF Mutations

Direct Detection of TMPRSS2-ERG Rearrangements in Prostate Cancer by Padlock Probes

Kiflemariam, Sara; Mignardi, M.; Bergh, A.; Nilsson, M. et al.

Ingår i European Journal of Cancer, 2012

• DOI för Direct Detection of TMPRSS2-ERG Rearrangements in Prostate Cancer by Padlock Probes

Scalable In Situ Hybridization on Tissue Arrays for Validation of Novel Cancer and Tissue-Specific Biomarkers

Kiflemariam, Sara; Andersson, Sandra; Asplund, Anna; Pontén, Fredrik et al.

Ingår i PLOS ONE, 2012

• DOI för Scalable In Situ Hybridization on Tissue Arrays for Validation of Novel Cancer and Tissue-Specific Biomarkers
• Ladda ner fulltext (pdf) av Scalable In Situ Hybridization on Tissue Arrays for Validation of Novel Cancer and Tissue-Specific Biomarkers

Somatic mutations in the notch, NF-KB, PIK3CA, and hedgehog pathways in human breast cancers

Jiao, Xiang; Wood, Laura D.; Lindman, Monica; Jones, Sian et al.

Ingår i Genes, Chromosomes and Cancer, s. 480-489, 2012

• DOI för Somatic mutations in the notch, NF-KB, PIK3CA, and hedgehog pathways in human breast cancers

The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy

Hernlund, Emma; Olofsson, Maria Hägg; Fayad, Walid; Fryknäs, Mårten et al.

Ingår i European Journal of Cancer, s. 396-406, 2012

• DOI för The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy

Common pathogenetic mechanism involving human chromosome 18 in familial and sporadic ileal carcinoid tumors

Cunningham, Janet L.; Díaz de Ståhl, Teresita; Sjöblom, Tobias; Westin, Gunnar et al.

Ingår i Genes, Chromosomes and Cancer, s. 82-94, 2011

• DOI för Common pathogenetic mechanism involving human chromosome 18 in familial and sporadic ileal carcinoid tumors

Structural Alterations from Multiple Displacement Amplification of a Human Genome Revealed by Mate-Pair Sequencing

Jiao, Xiang; Rosenlund, Magnus; Hooper, Sean D.; Tellgren-Roth, Christian et al.

Ingår i PLOS ONE, 2011

• DOI för Structural Alterations from Multiple Displacement Amplification of a Human Genome Revealed by Mate-Pair Sequencing
• Ladda ner fulltext (pdf) av Structural Alterations from Multiple Displacement Amplification of a Human Genome Revealed by Mate-Pair Sequencing

Targeted resequencing of candidate genes using Selector Probes

Johansson, Henrik; Isaksson, Magnus; Sörqvist, Elin Falk; Roos, F. et al.

Ingår i Nucleic Acids Research, 2011

• DOI för Targeted resequencing of candidate genes using Selector Probes

Efficient and scalable serial extraction of DNA and RNA from frozen tissue samples

Mathot, Lucy; Lindman, Monica; Sjöblom, Tobias

Ingår i Chemical Communications, s. 547-549, 2010

• DOI för Efficient and scalable serial extraction of DNA and RNA from frozen tissue samples

Molecular pathways in tumor progression: from discovery to functional understanding

Ali, Muhammad Akhtar; Sjöblom, Tobias

Ingår i Molecular bioSystems, s. 902-908, 2009

• DOI för Molecular pathways in tumor progression: from discovery to functional understanding

Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer

Paulsson, Janna; Sjöblom, Tobias; Micke, Patrick; Pontén, Fredrik et al.

Ingår i American Journal of Pathology, s. 334-341, 2009

• DOI för Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer

Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis

Gal, Annamaria; Sjöblom, Tobias; Fedorova, L.; Imreh, S. et al.

Ingår i Oncogene, s. 1218-1230, 2008

• DOI för Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis

Systematic analyses of the cancer genome: Lessons learned from sequencing most of the annotated human protein-coding genes

Sjöblom, Tobias

Ingår i Current Opinion in Oncology, s. 66-71, 2008

• DOI för Systematic analyses of the cancer genome: Lessons learned from sequencing most of the annotated human protein-coding genes

A multidimensional analysis of genes mutated in breast and colorectal cancers

Lin, Jimmy; Gan, Christine M; Zhang, Xiaosong; Jones, Siân et al.

Ingår i Genome Research, s. 1304-1318, 2007

• DOI för A multidimensional analysis of genes mutated in breast and colorectal cancers

In situ detection of phosphorylated platelet-derived growth factor receptor beta using a generalized proximity ligation method

Jarvius, Malin; Paulsson, Janna; Weibrecht, Irene; Leuchowius, Karl-Johan et al.

Ingår i Molecular & Cellular Proteomics, s. 1500-1509, 2007

• DOI för In situ detection of phosphorylated platelet-derived growth factor receptor beta using a generalized proximity ligation method

The genomic landscapes of human breast and colorectal cancers.

Wood, Laura D; Parsons, D Williams; Jones, Siân; Lin, Jimmy et al.

Ingår i Science, s. 1108-1113, 2007

• DOI för The genomic landscapes of human breast and colorectal cancers.

An antibody-based method for monitoring in vivo oxidation of protein tyrosine phosphatases

Persson, Camilla; Kappert, Kai; Engström, Ulla; Östman, Arne et al.

Ingår i Methods, s. 37-43, 2005

• DOI för An antibody-based method for monitoring in vivo oxidation of protein tyrosine phosphatases

Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate

Furuhashi, Masao; Sjöblom, Tobias; Abramsson, Alexandra; Ellingsen, Jens et al.

Ingår i Cancer Research, s. 2725-2733, 2004

• DOI för Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate

Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases

Persson, Camilla; Sjöblom, Tobias; Groen, Arnoud; Kappert, Kai et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 1886-1891, 2004

• DOI för Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases

Smad2 suppresses the growth of Mv1Lu cells subcutaneously inoculated in mice

Sjöblom, Tobias; Yakymovych, Ihor; Heldin, Carl-Henrik; Östman, Arne et al.

Ingår i European Journal of Cancer, s. 267-274, 2004

• DOI för Smad2 suppresses the growth of Mv1Lu cells subcutaneously inoculated in mice

Transgenic overexpression of platelet-derived growth factor-C in the mouse heart induces cardiac fibrosis, hypertrophy, and dilated cardiomyopathy

Pontén, Annica; Li, Xuri; Thorén, Peter; Aase, Karin et al.

Ingår i American Journal of Pathology, s. 673-682, 2003

• DOI för Transgenic overexpression of platelet-derived growth factor-C in the mouse heart induces cardiac fibrosis, hypertrophy, and dilated cardiomyopathy

Tricyclic quinoxalines as potent kinase inhibitors of PDGFR kinase, Flt3 and Kit

Gazit, Aviv; Yee, Kevin; Uecker, Andrea; Böhmer, Frank-D. et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 2007-2018, 2003

• DOI för Tricyclic quinoxalines as potent kinase inhibitors of PDGFR kinase, Flt3 and Kit