Publications

High-efficiency transfection of Acanthamoeba castellanii using a cationic polymer

Moreno, Anaísa B.; Ek, Viktor; Eriksson, Jens; Sellin, Mikael E. et al.

Part of Cell Reports Methods, 2026

• DOI for High-efficiency transfection of Acanthamoeba castellanii using a cationic polymer
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Determinants of divergent Salmonella and Shigella epithelial colonization strategies resolved in human enteroids and colonoids

Geiser, Petra; Di Martino, Maria Letizia; Lopes, Ana C. C.; Bergholtz, Alexandra et al.

Part of mBio, p. 1-22, 2025

• DOI for Determinants of divergent Salmonella and Shigella epithelial colonization strategies resolved in human enteroids and colonoids
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Mast Cell Phenotypic Heterogeneity Impacts the Interplay with Pathogenic Salmonella Typhimurium Bacteria

von Beek, Christopher; Prensa, Grisna I.; Andersson, Julia H. M.; Pejler, Gunnar et al.

Part of European Journal of Immunology, 2025

• DOI for Mast Cell Phenotypic Heterogeneity Impacts the Interplay with Pathogenic Salmonella Typhimurium Bacteria
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Matrix-M adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization

Zarnegar, Behdad; Carow, Berit; Eriksson, Jens; Spennare, Eva et al.

Part of npj Vaccines, 2025

• DOI for Matrix-M adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization
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Maturation of Human Intestinal Epithelial Cell Layers Fortifies the Apical Surface against Salmonella Attack

van Rijn, jorva668; Lopes, Ana; Ceylan, Merve; Eriksson, Jens et al.

Part of Cell Reports, 2025

• DOI for Maturation of Human Intestinal Epithelial Cell Layers Fortifies the Apical Surface against Salmonella Attack
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NAIP/NLRC4 inflammasome dynamics in murine enteroids are tuned by NAIP ligand concentration and epithelial cell differentiation

Rosendahl Andreassen, Patrick; Ernst, Chantal; Pimentel Mendes, Marisa; Bill Andersen, Thea et al.

Part of Cell Reports, 2025

• DOI for NAIP/NLRC4 inflammasome dynamics in murine enteroids are tuned by NAIP ligand concentration and epithelial cell differentiation
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Optimized Artificial Colonic Mucus Enabling Physiologically Relevant Diffusion Studies of Drugs, Particles, and Delivery Systems

Tjakra, Marco; Chakrapeesirisuk, Nopdanai; Jacobson, Magdalena; Sellin, Mikael E. et al.

Part of Molecular Pharmaceutics, p. 4032-4045, 2025

• DOI for Optimized Artificial Colonic Mucus Enabling Physiologically Relevant Diffusion Studies of Drugs, Particles, and Delivery Systems
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The pcnB gene sustains Shigella flexneri virulence

Frisch, Thibault; Geiser, Petra; Komi, Margarita; Karlsson, Philip A. et al.

Part of PLoS Pathogens, 2025

• DOI for The pcnB gene sustains Shigella flexneri virulence
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A two-step activation mechanism enables mast cells to differentiate their response between extracellular and invasive enterobacterial infection

von Beek, Christopher; Fahlgren, Anna; Geiser, Petra; Di Martino, Maria Letizia et al.

Part of Nature Communications, 2024

• DOI for A two-step activation mechanism enables mast cells to differentiate their response between extracellular and invasive enterobacterial infection
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Direct Salmonella injection into enteroid cells allows the study of host-pathogen interactions in the cytosol with high spatiotemporal resolution

Ernst, Chantal; Andreassen, Patrick R.; Giger, Gabriel H.; Nguyen, Bidong D. et al.

Part of PLoS biology, 2024

• DOI for Direct Salmonella injection into enteroid cells allows the study of host-pathogen interactions in the cytosol with high spatiotemporal resolution
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Equine enteroid-derived monolayers recapitulate key features of parasitic intestinal nematode infection

Hellman, Stina; Martin, Frida; Tyden, Eva; Sellin, Mikael E. et al.

Part of Veterinary research (Print), 2024

• DOI for Equine enteroid-derived monolayers recapitulate key features of parasitic intestinal nematode infection
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OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids

Mickols, Evgeniya; Meyer, Alina; Handin, Niklas; Stüwe, Malin et al.

Part of Scientific Reports, 2024

• DOI for OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids
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ProQ-dependent activation of Salmonella virulence genes mediated by post-transcriptional control of PhoP synthesis

Bergman, Sofia; Andresen, Liis; Kjellin, Jonas; Burgo, Yolanda Martinez et al.

Part of mSphere, 2024

• DOI for ProQ-dependent activation of Salmonella virulence genes mediated by post-transcriptional control of PhoP synthesis
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Salmonella T3SS-2 virulence enhances gut-luminal colonization by enabling chemotaxis-dependent exploitation of intestinal inflammation

Gül, Ersin; Huuskonen, Jemina; Younes, Andrew Abi; Maurer, Luca et al.

Part of Cell Reports, 2024

• DOI for Salmonella T3SS-2 virulence enhances gut-luminal colonization by enabling chemotaxis-dependent exploitation of intestinal inflammation
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Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites

Kaur, Amanpreet; Lin, Weifeng; Dovhalyuk, Vladyslav; Driutti, Léna et al.

Part of Chemical Science, p. 5291-5301, 2023

• DOI for Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites
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Epithelial and microbial determinants of colonic drug distribution

Hammar, Rebekkah; Sellin, Mikael E.; Artursson, Per

Part of European Journal of Pharmaceutical Sciences, 2023

• DOI for Epithelial and microbial determinants of colonic drug distribution
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Epithelial inflammasomes, gasdermins, and mucosal inflammation - Lessons from Salmonella and Shigella infected mice

Gul, Ersin; Fattinger, Stefan A.; Sellin, Mikael E.; Hardt, Wolf-Dietrich

Part of Seminars in Immunology, 2023

• DOI for Epithelial inflammasomes, gasdermins, and mucosal inflammation - Lessons from Salmonella and Shigella infected mice

Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice

Fattinger, Stefan A.; Maurer, Luca; Geiser, Petra; Bernard, Elliott M. et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2023

• DOI for Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice
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Intraluminal neutrophils limit epithelium damage by reducing pathogen assault on intestinal epithelial cells during Salmonella gut infection

Gül, Ersin; Enz, Ursina; Maurer, Luca; Abi Younes, Andrew et al.

Part of PLoS Pathogens, 2023

• DOI for Intraluminal neutrophils limit epithelium damage by reducing pathogen assault on intestinal epithelial cells during Salmonella gut infection
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The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition

Tzavlaki, Kalliopi; Ohata, Yae; Morén, Anita; Watanabe, Yukihide et al.

Part of Journal of Cellular Physiology, p. 790-812, 2023

• DOI for The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition
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Trophozoite fitness dictates the intestinal epithelial cell response to Giardia intestinalis infection

Grüttner, Jana; van Rijn, Jorik M.; Geiser, Petra; Florbrant, Alexandra et al.

Part of PLoS Pathogens, 2023

• DOI for Trophozoite fitness dictates the intestinal epithelial cell response to Giardia intestinalis infection
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A motile doublet form of Salmonella Typhimurium diversifies target search behavior at the epithelial surface

Ek, Viktor; Fattinger, Stefan A.; Florbrant, Alexandra; Hardt, Wolf-Dietrich et al.

Part of Molecular Microbiology, p. 1156-1172, 2022

• DOI for A motile doublet form of Salmonella Typhimurium diversifies target search behavior at the epithelial surface
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High-Definition DIC Imaging Uncovers Transient Stages of Pathogen Infection Cycles on the Surface of Human Adult Stem Cell-Derived Intestinal Epithelium

van Rijn, Jorik M.; Eriksson, Jens; Grüttner, Jana; Sundbom, Magnus et al.

Part of mBio, 2022

• DOI for High-Definition DIC Imaging Uncovers Transient Stages of Pathogen Infection Cycles on the Surface of Human Adult Stem Cell-Derived Intestinal Epithelium
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IgE cross-linking induces activation of human and mouse mast cell progenitors

Mendez-Enriquez, Erika; Salomonsson, Maya; Eriksson, Jens; Janson, Christer et al.

Part of Journal of Allergy and Clinical Immunology, p. 1458-1463, 2022

• DOI for IgE cross-linking induces activation of human and mouse mast cell progenitors
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TGF beta selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition

Tsubakihara, Yutaro; Ohata, Yae; Okita, Yukari; Younis, Shady et al.

Part of Molecular Oncology, p. 2330-2354, 2022

• DOI for TGF beta selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition
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The VirF(21):VirF(30) protein ratio is affected by temperature and impacts Shigella flexneri host cell invasion

Skovajsova, Eva; Colonna, Bianca; Prosseda, Gianni; Sellin, Mikael E. et al.

Part of FEMS Microbiology Letters, 2022

• DOI for The VirF(21):VirF(30) protein ratio is affected by temperature and impacts Shigella flexneri host cell invasion
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Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers

Samperio Ventayol, Pilar; Geiser, Petra; Di Martino, Maria Letizia; Florbrant, Alexandra et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2021

• DOI for Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers
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Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells

von Beek, Christopher; Alriksson, Linnéa; Palle, Josefine; Gustafson, Ann-Marie et al.

Part of PLOS ONE, 2021

• DOI for Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells
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Epithelial inflammasomes in the defense against Salmonella gut infection

Fattinger, Stefan A.; Sellin, Mikael E.; Hardt, Wolf-Dietrich

Part of Current Opinion in Microbiology, p. 86-94, 2021

• DOI for Epithelial inflammasomes in the defense against Salmonella gut infection
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Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice

Fattinger, Stefan A.; Geiser, Petra; Samperio Ventayol, Pilar; Di Martino, Maria Letizia et al.

Part of Mucosal Immunology, p. 615-629, 2021

• DOI for Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice
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Intercrypt sentinel macrophages tune antibacterial NF-kappa B responses in gut epithelial cells via TNF

Hausmann, Annika; Felmy, Boas; Kunz, Leo; Kroon, Sanne et al.

Part of Journal of Experimental Medicine, 2021

• DOI for Intercrypt sentinel macrophages tune antibacterial NF-kappa B responses in gut epithelial cells via TNF
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Salmonella effector driven invasion of the gut epithelium: breaking in and setting the house on fire

Fattinger, Stefan A.; Sellin, Mikael E.; Hardt, Wolf-Dietrich

Part of Current Opinion in Microbiology, p. 9-18, 2021

• DOI for Salmonella effector driven invasion of the gut epithelium: breaking in and setting the house on fire
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Salmonella enterica Serovar Typhimurium Exploits Cycling through Epithelial Cells To Colonize Human and Murine Enteroids

Geiser, Petra; Di Martino, Maria Letizia; Samperio Ventayol, Pilar; Eriksson, Jens et al.

Part of mBio, 2021

• DOI for Salmonella enterica Serovar Typhimurium Exploits Cycling through Epithelial Cells To Colonize Human and Murine Enteroids
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Germ-free and microbiota-associated mice yield small intestinal epithelial organoids with equivalent and robust transcriptome/proteome expression phenotypes

Hausmann, Annika; Russo, Giancarlo; Grossmann, Jonas; Zünd, Mirjam et al.

Part of Cellular Microbiology, 2020

• DOI for Germ-free and microbiota-associated mice yield small intestinal epithelial organoids with equivalent and robust transcriptome/proteome expression phenotypes
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Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression

Hausmann, Annika; Böck, Desirée; Geiser, Petra; Berthold, Dorothée L. et al.

Part of Mucosal Immunology, p. 530-544, 2020

• DOI for Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression
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Salmonella Typhimurium discreet-invasion of the murine gut absorptive epithelium

Fattinger, Stefan A.; Bock, Desiree; Di Martino, Maria Letizia; Deuring, Sabrina et al.

Part of PLoS Pathogens, 2020

• DOI for Salmonella Typhimurium discreet-invasion of the murine gut absorptive epithelium
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Barcoded Consortium Infections Resolve Cell Type-Dependent Salmonella enterica Serovar Typhimurium Entry Mechanisms

Di Martino, Maria Letizia; Ek, Viktor; Hardt, Wolf-Dietrich; Eriksson, Jens et al.

Part of mBio, 2019

• DOI for Barcoded Consortium Infections Resolve Cell Type-Dependent Salmonella enterica Serovar Typhimurium Entry Mechanisms
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Lysosomotropic challenge of mast cells causes intra-granular reactive oxygen species production

Paivandy, Aida; Eriksson, Jens; Melo, Fabio R.; Sellin, Mikael E. et al.

Part of Cell Death Discovery, 2019

• DOI for Lysosomotropic challenge of mast cells causes intra-granular reactive oxygen species production
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Mucispirillum schaedleri Antagonizes Salmonella Virulence to Protect Mice against Colitis

Herp, Simone; Brugiroux, Sandrine; Garzetti, Debora; Ring, Diana et al.

Part of Cell Host and Microbe, p. 681-69400000000, 2019

• DOI for Mucispirillum schaedleri Antagonizes Salmonella Virulence to Protect Mice against Colitis

Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract

Furter, Markus; Sellin, Mikael E.; Hansson, Gunnar C.; Hardt, Wolf-Dietrich

Part of Cell Reports, p. 2665-26788.e1–e3, 2019

• DOI for Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract
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Salmonella persisters promote the spread of antibiotic resistance plasmids in the gut

Bakkeren, Erik; Huisman, Jana S.; Fattinger, Stefan A.; Hausmann, Annika et al.

Part of Nature, p. 276-280, 2019

• DOI for Salmonella persisters promote the spread of antibiotic resistance plasmids in the gut

Streptococcal sagA activates a proinflammatory response in mast cells by a sublytic mechanism

von Beek, Christopher; Waern, Ida; Eriksson, Jens; Melo, Fabio R. et al.

Part of Cellular Microbiology, 2019

• DOI for Streptococcal sagA activates a proinflammatory response in mast cells by a sublytic mechanism
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The Major RNA-Binding Protein ProQ Impacts Virulence Gene Expression in Salmonella enterica Serovar Typhimurium

Westermann, Alexander J.; Venturini, Elisa; Sellin, Mikael E.; Förstner, Konrad U et al.

Part of mBio, 2019

• DOI for The Major RNA-Binding Protein ProQ Impacts Virulence Gene Expression in Salmonella enterica Serovar Typhimurium
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Consequences of Epithelial Inflammasome Activation by Bacterial Pathogens

Sellin, Mikael E.; Müller, Anna A; Hardt, Wolf-Dietrich

Part of Journal of Molecular Biology, p. 193-206, 2018

• DOI for Consequences of Epithelial Inflammasome Activation by Bacterial Pathogens

High-avidity IgA protects the intestine by enchaining growing bacteria

Moor, Kathrin; Diard, Mederic; Sellin, Mikael E.; Felmy, Boas et al.

Part of Nature, p. 498-+, 2017

• DOI for High-avidity IgA protects the intestine by enchaining growing bacteria

Inflammation boosts bacteriophage transfer between Salmonella spp.

Diard, Mederic; Bakkeren, Erik; Cornuault, Jeffrey K.; Moor, Kathrin et al.

Part of Science, p. 1211-1215, 2017

• DOI for Inflammation boosts bacteriophage transfer between Salmonella spp.

An NK Cell Perforin Response Elicited via IL-18 Controls Mucosal Inflammation Kinetics during Salmonella Gut Infection

Mueller, Anna A.; Dolowschiak, Tamas; Sellin, Mikael E.; Felmy, Boas et al.

Part of PLoS Pathogens, 2016

• DOI for An NK Cell Perforin Response Elicited via IL-18 Controls Mucosal Inflammation Kinetics during Salmonella Gut Infection
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IFN-γ Hinders Recovery from Mucosal Inflammation during Antibiotic Therapy for Salmonella Gut Infection.

Dolowschiak, Tamas; Mueller, Anna Angelika; Pisan, Lynn Joanna; Feigelman, Rounak et al.

Part of Cell Host and Microbe, 2016

• DOI for IFN-γ Hinders Recovery from Mucosal Inflammation during Antibiotic Therapy for Salmonella Gut Infection.

Inflammasomes of the intestinal epithelium

Sellin, Mikael E.; Maslowski, Kendle M.; Maloy, Kevin J.; Wolf-Dietrich, Hardt

Part of Trends in immunology, p. 442-450, 2015

• DOI for Inflammasomes of the intestinal epithelium

A Generic Method for Design of Oligomer-Specific Antibodies

Brännström, Kristoffer; Lindhagen-Persson, Malin; Gharibyan, Anna L.; Iakovleva, Irina et al.

Part of PLOS ONE, 2014

• DOI for A Generic Method for Design of Oligomer-Specific Antibodies