Publications

A two-step activation mechanism enables mast cells to differentiate their response between extracellular and invasive enterobacterial infection

von Beek, Christopher; Fahlgren, Anna; Geiser, Petra; Di Martino, Maria Letizia et al.

Part of Nature Communications, 2024

• DOI for A two-step activation mechanism enables mast cells to differentiate their response between extracellular and invasive enterobacterial infection
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Direct Salmonella injection into enteroid cells allows the study of host-pathogen interactions in the cytosol with high spatiotemporal resolution

Ernst, Chantal; Andreassen, Patrick R.; Giger, Gabriel H.; Nguyen, Bidong D. et al.

Part of PLoS biology, 2024

• DOI for Direct Salmonella injection into enteroid cells allows the study of host-pathogen interactions in the cytosol with high spatiotemporal resolution
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Equine enteroid-derived monolayers recapitulate key features of parasitic intestinal nematode infection

Hellman, Stina; Martin, Frida; Tyden, Eva; Sellin, Mikael E. et al.

Part of Veterinary research (Print), 2024

• DOI for Equine enteroid-derived monolayers recapitulate key features of parasitic intestinal nematode infection
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OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids

Mickols, Evgeniya; Meyer, Alina; Handin, Niklas; Stüwe, Malin et al.

Part of Scientific Reports, 2024

• DOI for OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids
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ProQ-dependent activation of Salmonella virulence genes mediated by post-transcriptional control of PhoP synthesis

Berggren, Sofia; Andresen, Liis; Kjellin, Jonas; Burgo, Yolanda Martinez et al.

Part of mSphere, 2024

• DOI for ProQ-dependent activation of Salmonella virulence genes mediated by post-transcriptional control of PhoP synthesis
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Salmonella T3SS-2 virulence enhances gut-luminal colonization by enabling chemotaxis-dependent exploitation of intestinal inflammation

Gül, Ersin; Huuskonen, Jemina; Younes, Andrew Abi; Maurer, Luca et al.

Part of Cell Reports, 2024

• DOI for Salmonella T3SS-2 virulence enhances gut-luminal colonization by enabling chemotaxis-dependent exploitation of intestinal inflammation
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Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites

Kaur, Amanpreet; Lin, Weifeng; Dovhalyuk, Vladyslav; Driutti, Léna et al.

Part of Chemical Science, p. 5291-5301, 2023

• DOI for Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites
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Epithelial and microbial determinants of colonic drug distribution

Hammar, Rebekkah; Sellin, Mikael E.; Artursson, Per

Part of European Journal of Pharmaceutical Sciences, 2023

• DOI for Epithelial and microbial determinants of colonic drug distribution
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Epithelial inflammasomes, gasdermins, and mucosal inflammation - Lessons from Salmonella and Shigella infected mice

Gul, Ersin; Fattinger, Stefan A.; Sellin, Mikael E.; Hardt, Wolf-Dietrich

Part of Seminars in Immunology, 2023

• DOI for Epithelial inflammasomes, gasdermins, and mucosal inflammation - Lessons from Salmonella and Shigella infected mice

Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice

Fattinger, Stefan A.; Maurer, Luca; Geiser, Petra; Bernard, Elliott M. et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2023

• DOI for Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice
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Intraluminal neutrophils limit epithelium damage by reducing pathogen assault on intestinal epithelial cells during Salmonella gut infection

Gül, Ersin; Enz, Ursina; Maurer, Luca; Abi Younes, Andrew et al.

Part of PLoS Pathogens, 2023

• DOI for Intraluminal neutrophils limit epithelium damage by reducing pathogen assault on intestinal epithelial cells during Salmonella gut infection
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The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition

Tzavlaki, Kalliopi; Ohata, Yae; Morén, Anita; Watanabe, Yukihide et al.

Part of Journal of Cellular Physiology, p. 790-812, 2023

• DOI for The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition
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Trophozoite fitness dictates the intestinal epithelial cell response to Giardia intestinalis infection

Grüttner, Jana; van Rijn, Jorik M.; Geiser, Petra; Florbrant, Alexandra et al.

Part of PLoS Pathogens, 2023

• DOI for Trophozoite fitness dictates the intestinal epithelial cell response to Giardia intestinalis infection
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A motile doublet form of Salmonella Typhimurium diversifies target search behavior at the epithelial surface

Ek, Viktor; Fattinger, Stefan A.; Florbrant, Alexandra; Hardt, Wolf-Dietrich et al.

Part of Molecular Microbiology, p. 1156-1172, 2022

• DOI for A motile doublet form of Salmonella Typhimurium diversifies target search behavior at the epithelial surface
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High-Definition DIC Imaging Uncovers Transient Stages of Pathogen Infection Cycles on the Surface of Human Adult Stem Cell-Derived Intestinal Epithelium

van Rijn, Jorik M.; Eriksson, Jens; Grüttner, Jana; Sundbom, Magnus et al.

Part of mBio, 2022

• DOI for High-Definition DIC Imaging Uncovers Transient Stages of Pathogen Infection Cycles on the Surface of Human Adult Stem Cell-Derived Intestinal Epithelium
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IgE cross-linking induces activation of human and mouse mast cell progenitors

Mendez-Enriquez, Erika; Salomonsson, Maya; Eriksson, Jens; Janson, Christer et al.

Part of Journal of Allergy and Clinical Immunology, p. 1458-1463, 2022

• DOI for IgE cross-linking induces activation of human and mouse mast cell progenitors
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TGF beta selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition

Tsubakihara, Yutaro; Ohata, Yae; Okita, Yukari; Younis, Shady et al.

Part of Molecular Oncology, p. 2330-2354, 2022

• DOI for TGF beta selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition
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The VirF(21):VirF(30) protein ratio is affected by temperature and impacts Shigella flexneri host cell invasion

Skovajsova, Eva; Colonna, Bianca; Prosseda, Gianni; Sellin, Mikael E. et al.

Part of FEMS Microbiology Letters, 2022

• DOI for The VirF(21):VirF(30) protein ratio is affected by temperature and impacts Shigella flexneri host cell invasion
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Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers

Samperio Ventayol, Pilar; Geiser, Petra; Di Martino, Maria Letizia; Florbrant, Alexandra et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2021

• DOI for Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers
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Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells

von Beek, Christopher; Alriksson, Linnéa; Palle, Josefine; Gustafson, Ann-Marie et al.

Part of PLOS ONE, 2021

• DOI for Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells
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Epithelial inflammasomes in the defense against Salmonella gut infection

Fattinger, Stefan A.; Sellin, Mikael E.; Hardt, Wolf-Dietrich

Part of Current Opinion in Microbiology, p. 86-94, 2021

• DOI for Epithelial inflammasomes in the defense against Salmonella gut infection
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Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice

Fattinger, Stefan A.; Geiser, Petra; Samperio Ventayol, Pilar; Di Martino, Maria Letizia et al.

Part of Mucosal Immunology, p. 615-629, 2021

• DOI for Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice
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Intercrypt sentinel macrophages tune antibacterial NF-kappa B responses in gut epithelial cells via TNF

Hausmann, Annika; Felmy, Boas; Kunz, Leo; Kroon, Sanne et al.

Part of Journal of Experimental Medicine, 2021

• DOI for Intercrypt sentinel macrophages tune antibacterial NF-kappa B responses in gut epithelial cells via TNF
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Salmonella effector driven invasion of the gut epithelium: breaking in and setting the house on fire

Fattinger, Stefan A.; Sellin, Mikael E.; Hardt, Wolf-Dietrich

Part of Current Opinion in Microbiology, p. 9-18, 2021

• DOI for Salmonella effector driven invasion of the gut epithelium: breaking in and setting the house on fire
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Salmonella enterica Serovar Typhimurium Exploits Cycling through Epithelial Cells To Colonize Human and Murine Enteroids

Geiser, Petra; Di Martino, Maria Letizia; Samperio Ventayol, Pilar; Eriksson, Jens et al.

Part of mBio, 2021

• DOI for Salmonella enterica Serovar Typhimurium Exploits Cycling through Epithelial Cells To Colonize Human and Murine Enteroids
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Germ-free and microbiota-associated mice yield small intestinal epithelial organoids with equivalent and robust transcriptome/proteome expression phenotypes

Hausmann, Annika; Russo, Giancarlo; Grossmann, Jonas; Zünd, Mirjam et al.

Part of Cellular Microbiology, 2020

• DOI for Germ-free and microbiota-associated mice yield small intestinal epithelial organoids with equivalent and robust transcriptome/proteome expression phenotypes
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Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression

Hausmann, Annika; Böck, Desirée; Geiser, Petra; Berthold, Dorothée L. et al.

Part of Mucosal Immunology, p. 530-544, 2020

• DOI for Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression
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Salmonella Typhimurium discreet-invasion of the murine gut absorptive epithelium

Fattinger, Stefan A.; Bock, Desiree; Di Martino, Maria Letizia; Deuring, Sabrina et al.

Part of PLoS Pathogens, 2020

• DOI for Salmonella Typhimurium discreet-invasion of the murine gut absorptive epithelium
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Barcoded Consortium Infections Resolve Cell Type-Dependent Salmonella enterica Serovar Typhimurium Entry Mechanisms

Di Martino, Maria Letizia; Ek, Viktor; Hardt, Wolf-Dietrich; Eriksson, Jens et al.

Part of mBio, 2019

• DOI for Barcoded Consortium Infections Resolve Cell Type-Dependent Salmonella enterica Serovar Typhimurium Entry Mechanisms
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Lysosomotropic challenge of mast cells causes intra-granular reactive oxygen species production

Paivandy, Aida; Eriksson, Jens; Melo, Fabio R.; Sellin, Mikael E. et al.

Part of Cell Death Discovery, 2019

• DOI for Lysosomotropic challenge of mast cells causes intra-granular reactive oxygen species production
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Mucispirillum schaedleri Antagonizes Salmonella Virulence to Protect Mice against Colitis

Herp, Simone; Brugiroux, Sandrine; Garzetti, Debora; Ring, Diana et al.

Part of Cell Host and Microbe, p. 681-69400000000, 2019

• DOI for Mucispirillum schaedleri Antagonizes Salmonella Virulence to Protect Mice against Colitis

Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract

Furter, Markus; Sellin, Mikael E.; Hansson, Gunnar C.; Hardt, Wolf-Dietrich

Part of Cell Reports, p. 2665-26788.e1–e3, 2019

• DOI for Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract
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Salmonella persisters promote the spread of antibiotic resistance plasmids in the gut

Bakkeren, Erik; Huisman, Jana S.; Fattinger, Stefan A.; Hausmann, Annika et al.

Part of Nature, p. 276-280, 2019

• DOI for Salmonella persisters promote the spread of antibiotic resistance plasmids in the gut

Streptococcal sagA activates a proinflammatory response in mast cells by a sublytic mechanism

von Beek, Christopher; Waern, Ida; Eriksson, Jens; Melo, Fabio R. et al.

Part of Cellular Microbiology, 2019

• DOI for Streptococcal sagA activates a proinflammatory response in mast cells by a sublytic mechanism
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The Major RNA-Binding Protein ProQ Impacts Virulence Gene Expression in Salmonella enterica Serovar Typhimurium

Westermann, Alexander J.; Venturini, Elisa; Sellin, Mikael E.; Förstner, Konrad U et al.

Part of mBio, 2019

• DOI for The Major RNA-Binding Protein ProQ Impacts Virulence Gene Expression in Salmonella enterica Serovar Typhimurium
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Consequences of Epithelial Inflammasome Activation by Bacterial Pathogens

Sellin, Mikael E.; Müller, Anna A; Hardt, Wolf-Dietrich

Part of Journal of Molecular Biology, p. 193-206, 2018

• DOI for Consequences of Epithelial Inflammasome Activation by Bacterial Pathogens

High-avidity IgA protects the intestine by enchaining growing bacteria

Moor, Kathrin; Diard, Mederic; Sellin, Mikael E.; Felmy, Boas et al.

Part of Nature, p. 498-+, 2017

• DOI for High-avidity IgA protects the intestine by enchaining growing bacteria

Inflammation boosts bacteriophage transfer between Salmonella spp.

Diard, Mederic; Bakkeren, Erik; Cornuault, Jeffrey K.; Moor, Kathrin et al.

Part of Science, p. 1211-1215, 2017

• DOI for Inflammation boosts bacteriophage transfer between Salmonella spp.

An NK Cell Perforin Response Elicited via IL-18 Controls Mucosal Inflammation Kinetics during Salmonella Gut Infection

Mueller, Anna A.; Dolowschiak, Tamas; Sellin, Mikael E.; Felmy, Boas et al.

Part of PLoS Pathogens, 2016

• DOI for An NK Cell Perforin Response Elicited via IL-18 Controls Mucosal Inflammation Kinetics during Salmonella Gut Infection
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IFN-γ Hinders Recovery from Mucosal Inflammation during Antibiotic Therapy for Salmonella Gut Infection.

Dolowschiak, Tamas; Mueller, Anna Angelika; Pisan, Lynn Joanna; Feigelman, Rounak et al.

Part of Cell Host and Microbe, 2016

• DOI for IFN-γ Hinders Recovery from Mucosal Inflammation during Antibiotic Therapy for Salmonella Gut Infection.

Inflammasomes of the intestinal epithelium

Sellin, Mikael E.; Maslowski, Kendle M.; Maloy, Kevin J.; Wolf-Dietrich, Hardt

Part of Trends in immunology, p. 442-450, 2015

• DOI for Inflammasomes of the intestinal epithelium

A Generic Method for Design of Oligomer-Specific Antibodies

Brännström, Kristoffer; Lindhagen-Persson, Malin; Gharibyan, Anna L.; Iakovleva, Irina et al.

Part of PLOS ONE, 2014

• DOI for A Generic Method for Design of Oligomer-Specific Antibodies

Antibiotic treatment selects for cooperative virulence of Salmonella typhimurium.

Diard, Médéric; Sellin, Mikael E; Dolowschiak, Tamas; Arnoldini, Markus et al.

Part of Current Biology, 2014

• DOI for Antibiotic treatment selects for cooperative virulence of Salmonella typhimurium.

Cell type-specific expression of SEPT3-homology subgroup members controls the subunit number of heteromeric septin complexes

Sellin, Mikael E.; Stenmark, Sonja; Gullberg, Martin

Part of Molecular Biology of the Cell, p. 1594-1607, 2014

• DOI for Cell type-specific expression of SEPT3-homology subgroup members controls the subunit number of heteromeric septin complexes

Epithelium-intrinsic NAIP/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa

Sellin, Mikael E.; Müller, Anna A.; Felmy, Boas; Dolowschiak, Tamas et al.

Part of Cell Host and Microbe, p. 237-248, 2014

• DOI for Epithelium-intrinsic NAIP/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa

Granulocytes impose a tight bottleneck upon the gut luminal pathogen population during Salmonella typhimurium colitis.

Maier, Lisa; Diard, Médéric; Sellin, Mikael E; Chouffane, Elsa-Sarah et al.

Part of PLoS Pathogens, 2014

• DOI for Granulocytes impose a tight bottleneck upon the gut luminal pathogen population during Salmonella typhimurium colitis.

The Salmonella Typhimurium effector protein SopE transiently localizes to the early SCV and contributes to intracellular replication.

Vonaesch, Pascale; Sellin, Mikael E; Cardini, Steven; Singh, Vikash et al.

Part of Cellular Microbiology, 2014

• DOI for The Salmonella Typhimurium effector protein SopE transiently localizes to the early SCV and contributes to intracellular replication.

Quantitative insights into actin rearrangements and bacterial target site selection from Salmonella Typhimurium infection of micropatterned cells.

Vonaesch, Pascale; Cardini, Steven; Sellin, Mikael E; Goud, Bruno et al.

Part of Cellular Microbiology, 2013

• DOI for Quantitative insights into actin rearrangements and bacterial target site selection from Salmonella Typhimurium infection of micropatterned cells.

Mammalian SEPT9 isoforms direct microtubule-dependent arrangements of septin core heteromers

Sellin, Mikael E.; Stenmark, Sonja; Gullberg, Martin

Part of Molecular Biology of the Cell, p. 4242-4255, 2012

• DOI for Mammalian SEPT9 isoforms direct microtubule-dependent arrangements of septin core heteromers

Deciphering the rules governing assembly order of mammalian septin complexes

Sellin, Mikael E.; Sandblad, Linda; Stenmark, Sonja; Gullberg, Martin

Part of Molecular Biology of the Cell, p. 3152-3164, 2011

• DOI for Deciphering the rules governing assembly order of mammalian septin complexes