Hanna Karlsson, Professor of Toxicology: “Together we can make a positive difference”

Every day, we are exposed to a diversity of chemical substances and particles. In line with the development of new advanced materials – including nanomaterials – as well as the increased occurrence of microplastics in both the environment and the human body, it is becoming increasingly urgent to extend our knowledge of how these materials might affect our health. In the fall of 2025, the Faculty of Pharmacy strengthens its position in the field with the recruitment of Hanna Karlsson, Professor of Toxicology.

“Identifying toxic effects and preventing health risks linked to particles is interdisciplinary work in every way, and each day at Uppsala University I am reminded of the many strengths that broad research and a dedicated Faculty of Pharmacy bring. The fact that this academic environment is also both inclusive and curious further contributes to the flow of ideas on possible collaborations with clear added value for all parties and where we together can make a positive difference,” says Hanna Karlsson.

The research group’s work covers a wide spectrum of particles, from those generated during 3D printing and welding, from tire wear and microplastics, to those existing in environments such as airports and subways. A central focus is to clarify how different particle properties – for example, size – can affect their biological effects. Another important aspect is the development and evaluation of different cell models that can help increase our knowledge about the health effects of particles while offering alternatives to animal experiments.

“Particles are complex entities that shift in both composition and structure based on the environment in which they exist. This constantly raises new questions and needs for new knowledge from several different disciplines. A current example is the nano- and microplastics that are generated through the increasing use of plastic materials. Our research covers both fundamental questions regarding the interaction between materials and biological systems, as well as applied studies with the aim of providing scientific evidence for regulatory authorities.”

The overall goals of the research can be summarized as the development of safe products, cleaner air, and a healthier population. At the Uppsala Biomedical Center, Hanna is currently establishing the foundation for the research team that will drive the work forward. Together with colleagues at the Department of Pharmaceutical Biosciences, she is developing a range of new ideas, including those related to aerosol drug delivery. New recruitments are just around the corner, and the journey out of the starting blocks seems to continue at full speed.

“After 25 years at Karolinska Institutet, it is exciting to explore new terrain, and I have really been well received by my new colleagues. In November, I experienced the magnificent Inauguration of Professors with a wonderful dinner at Uppsala Castle. I constantly meet interesting people and see new opportunities where my knowledge can add value to their research and vice versa, so I can only say that we’re entering 2026 with great inspiration and confidence.”

Text: Magnus Alsne, photo: Private, Pexels