Our recent publications

Exploring the Role of Photolysis in the Aquatic Fate of Antimicrobial Transformation Products: Implications for One Health

Löffler, Paul; Henschel, Henning; Ugolini, Valentina; Flores Quintana, Harold et al.

Part of ACS - ES & T Water, 2025

Article in journal

• DOI for Exploring the Role of Photolysis in the Aquatic Fate of Antimicrobial Transformation Products: Implications for One Health

Regioselective Palladaelectro-Catalyzed Chlorination of Arenes in an Undivided Cell

Ponra, Sudipta; Sitdikov, Ruzal; Calis, Alyssio; Verho, Oscar

Part of Advanced Synthesis and Catalysis, 2025

Article in journal

• DOI for Regioselective Palladaelectro-Catalyzed Chlorination of Arenes in an Undivided Cell
• Download full text (pdf) of Regioselective Palladaelectro-Catalyzed Chlorination of Arenes in an Undivided Cell

Carboxylate and coordination influence on the formation of an active RuV Oxo species

El-Abid, Jamal; Dorst, Kevin M.; Inge, Andrew K.; Verho, Oscar et al.

Part of Scientific Reports, 2025

Article in journal

• DOI for Carboxylate and coordination influence on the formation of an active RuV Oxo species
• Download full text (pdf) of Carboxylate and coordination influence on the formation of an active RuV Oxo species

Effects of collagen and chondroitin sulfate on relaxation at multiple magnetic field strengths

Aro, Olli-Pekka; Casula, Victor; Hänninen, Nina E.; Karjalainen, Jouni et al.

Part of Heliyon, 2025

Article in journal

• DOI for Effects of collagen and chondroitin sulfate on relaxation at multiple magnetic field strengths

The AMR Accelerator: from individual organizations to efficient antibiotic development partnerships

Fernow, Josepine; Olliver, Marie; Couet, William; Lagrange, Sophie et al.

Part of Nature reviews. Drug discovery, p. 1-2, 2025

Article in journal

• DOI for The AMR Accelerator: from individual organizations to efficient antibiotic development partnerships
• Download full text (pdf) of The AMR Accelerator: from individual organizations to efficient antibiotic development partnerships

Liquid crystal nanoparticles for oral combination antibiotic therapies: A strategy towards protecting commensal gut bacteria during treatment

He, Xiguo; Karlsson, Philip; Xiong, Ruisheng; Moodie, Lindon W. K. et al.

Part of Journal of Colloid and Interface Science, p. 287-300, 2025

Article in journal

• DOI for Liquid crystal nanoparticles for oral combination antibiotic therapies: A strategy towards protecting commensal gut bacteria during treatment
• Download full text (pdf) of Liquid crystal nanoparticles for oral combination antibiotic therapies: A strategy towards protecting commensal gut bacteria during treatment

The effect of gem-difluorination on the conformation and properties of a model macrocyclic system

Cogswell, T. J.; Lewis, R. J.; Sköld, Christian; Nordqvist, A. et al.

Part of Chemical Science, p. 19770-19776, 2024

Article in journal

• DOI for The effect of gem-difluorination on the conformation and properties of a model macrocyclic system
• Download full text (pdf) of The effect of gem-difluorination on the conformation and properties of a model macrocyclic system

Creating New Antifoulants Using the Tools and Tactics of Medicinal Chemistry

Cahill, Patrick L.; Moodie, Lindon W. K.; Hertzer, Cora; Pinori, Emiliano et al.

Part of Accounts of Chemical Research, p. 399-412, 2024

Article, review/survey

• DOI for Creating New Antifoulants Using the Tools and Tactics of Medicinal Chemistry

Co-complexes on modified graphite surface for steady green hydrogen production from water at neutral pH

Toledo-Carrillo, Esteban A.; Garcia-Rodriguez, Mario; Morallon, Emilia; Cazorla-Amoros, Diego et al.

Part of Frontiers in Chemistry, 2024

Article in journal

• DOI for Co-complexes on modified graphite surface for steady green hydrogen production from water at neutral pH
• Download full text (pdf) of Co-complexes on modified graphite surface for steady green hydrogen production from water at neutral pH

Synthesis of N-Alkenylated Heterocycles via T₃P-Promoted Condensation with Ketones

Balestri, Lorenzo Jacopo Ilic; Beveridge, Julia; Gising, Johan; Odell, Luke R.

Part of Journal of Organic Chemistry, p. 11203-11214, 2024

Article in journal

• DOI for Synthesis of N-Alkenylated Heterocycles via T₃P-Promoted Condensation with Ketones
• Download full text (pdf) of Synthesis of N-Alkenylated Heterocycles via T₃P-Promoted Condensation with Ketones

Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)

Beveridge, Julia; Söderström, Marcus; Prieto-Díaz, Rubén; Gutierrez-de-Teran, Hugo et al.

Part of European Journal of Medicinal Chemistry Reports, 2024

Article in journal

• DOI for Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)
• Download full text (pdf) of Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)

Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria

Huseby, Douglas L.; Cao, Sha; Zamaratski, Edouard; Sooriyaarachchi, Sanjeewani et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2024

Article in journal

• DOI for Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria
• Download full text (pdf) of Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria

Preparation of Simple Bicyclic Carboxylate-Rich Alicyclic Molecules for the Investigation of Dissolved Organic Matter

Craig, Alexander J.; Moodie, Lindon W. K.; Hawkes, Jeffrey A.

Part of Environmental Science and Technology, p. 7078-7086, 2024

Article in journal

• DOI for Preparation of Simple Bicyclic Carboxylate-Rich Alicyclic Molecules for the Investigation of Dissolved Organic Matter
• Download full text (pdf) of Preparation of Simple Bicyclic Carboxylate-Rich Alicyclic Molecules for the Investigation of Dissolved Organic Matter

N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands

Wannberg, Johan; Gising, Johan; Henriksson, Martin; Vo, Duc Duy et al.

Part of European Journal of Medicinal Chemistry, 2024

Article in journal

• DOI for N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
• Download full text (pdf) of N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands

The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds

Gising, Johan; Honarnejad, Saman; Bras, Maaike; Baillie, Gemma L. et al.

Part of International Journal of Molecular Sciences, 2024

Article in journal

• DOI for The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds
• Download full text (pdf) of The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds

Enhanced Risk Assessment of Transformation Products through Chemical Similarity Analysis

Löffler, Paul; Lai, Adelene; Henschel, Henning; Spilsbury, Francis et al.

Part of ACS - ES & T Water, p. 1949-1951, 2024

Article in journal

• DOI for Enhanced Risk Assessment of Transformation Products through Chemical Similarity Analysis
• Download full text (pdf) of Enhanced Risk Assessment of Transformation Products through Chemical Similarity Analysis

Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors

Benediktsdottir, Andrea; Sooriyaarachchi, Sanjeewani; Cao, Sha; Ottosson, Nina E. et al.

Part of European Journal of Medicinal Chemistry, 2024

Article in journal

• DOI for Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors
• Download full text (pdf) of Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors

Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries

Akaberi, Dario; Pourghasemi, Monireh; Krambrich, Janina; Berger, Julia et al.

Part of Antimicrobial Agents and Chemotherapy, p. 1-18, 2024

Article in journal

• DOI for Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries
• Download full text (pdf) of Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries

Green multifunctional palladium nanoparticles from polysaccharide cordia myxa (CMY) gum: Synthesis, characterization, and antibacterial activity

Nagaraja, Kasula; Bagineni, Prasad; Almarhoon, Zainab M.; Oh, Tae Hwan

Part of Colloids and Surfaces A, 2023

Article in journal

• DOI for Green multifunctional palladium nanoparticles from polysaccharide cordia myxa (CMY) gum: Synthesis, characterization, and antibacterial activity

C1 Building Blocks: New Approaches for Thiomethylations and Esterification

Söderström, Marcus

2023

Doctoral thesis, comprehensive summary

• Download full text (pdf) of C1 Building Blocks: New Approaches for Thiomethylations and Esterification

Thioacetalation and Multi-Component Thiomethylative Friedel-Crafts Arylation Using BF₃SMe₂

Söderström, Marcus; Matt, Christof; Odell, Luke R.

Part of ACS Omega, p. 4320-4330, 2023

Article in journal

• DOI for Thioacetalation and Multi-Component Thiomethylative Friedel-Crafts Arylation Using BF₃SMe₂
• Download full text (pdf) of Thioacetalation and Multi-Component Thiomethylative Friedel-Crafts Arylation Using BF₃SMe₂

Bifunctional and regenerable molecular electrode for water electrolysis at neutral pH

Das, Biswanath; Toledo-Carrillo, Esteban A.; Li, Guoqi; Stahle, Jonas et al.

Part of Journal of Materials Chemistry A, p. 13331-13340, 2023

Article in journal

• DOI for Bifunctional and regenerable molecular electrode for water electrolysis at neutral pH
• Download full text (pdf) of Bifunctional and regenerable molecular electrode for water electrolysis at neutral pH

A Base-Free, Low Temperature Click and Release Reaction for the In Situ Generation of Diazomethane

Schembri, Luke S; Olaniran, Esther; Söderström, Marcus; Skillinghaug, Bobo et al.

Part of Advanced Synthesis and Catalysis, p. 1839-1845, 2023

Article in journal

• DOI for A Base-Free, Low Temperature Click and Release Reaction for the In Situ Generation of Diazomethane
• Download full text (pdf) of A Base-Free, Low Temperature Click and Release Reaction for the In Situ Generation of Diazomethane

Antimicrobial Peptides Incorporating Halogenated Marine-Derived Amino Acid Substituents

Craig, Alexander J.; Ermolovich, Yuri; Cameron, Alan; Rodler, Agnes et al.

Part of ACS Medicinal Chemistry Letters, p. 802-809, 2023

Article in journal

• DOI for Antimicrobial Peptides Incorporating Halogenated Marine-Derived Amino Acid Substituents

Hybrid Machine Learning Approach to Predict the Site Selectivity of Iridium-Catalyzed Arene Borylation

Caldeweyher, Eike; Elkin, Masha; Gheibi, Golsa; Johansson, Magnus et al.

Part of Journal of the American Chemical Society, p. 17367-17376, 2023

Article in journal

• DOI for Hybrid Machine Learning Approach to Predict the Site Selectivity of Iridium-Catalyzed Arene Borylation

Characterization of a Newly Available Coastal Marine Dissolved Organic Matter Reference Material (TRM-0522)

Felgate, Stacey; Craig, Alexander J.; Moodie, Lindon W. K.; Hawkes, Jeffrey A.

Part of Analytical Chemistry, p. 6559-6567, 2023

Article in journal

• DOI for Characterization of a Newly Available Coastal Marine Dissolved Organic Matter Reference Material (TRM-0522)
• Download full text (pdf) of Characterization of a Newly Available Coastal Marine Dissolved Organic Matter Reference Material (TRM-0522)

Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

Calitz, Carlemi; Rosenquist, Jenny; Degerstedt, Oliver; Khaled, Jaafar et al.

Part of Scientific Reports, 2023

Article in journal

• DOI for Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma
• Download full text (pdf) of Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

Physiologically based biopharmaceutics modeling of regional and colon absorption in humans

Tannergren, Christer; Jadhav, Harshad; Eckernas, Emma; Fagerberg, Jonas et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 144-159, 2023

Article in journal

• DOI for Physiologically based biopharmaceutics modeling of regional and colon absorption in humans

On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI-MS Imaging

Kaya, Ibrahim; Schembri, Luke S; Nilsson, Anna; Shariatgorji, Reza et al.

Part of Journal of the American Society for Mass Spectrometry, p. 836-846, 2023

Article in journal

• DOI for On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI-MS Imaging
• Download full text (pdf) of On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI-MS Imaging

Novel food drug interaction mechanism involving acyclovir, chitosan and endogenous mucus

Garcia, Mauricio A.; Hensler, Gonul; Al-Gousous, Jozef; Pielenhofer, Jonas et al.

Part of Drug Metabolism and Pharmacokinetics, 2023

Article in journal

• DOI for Novel food drug interaction mechanism involving acyclovir, chitosan and endogenous mucus

SPICY: a method for single scan rotating frame relaxometry

Tolkkinen, Katja; Mailhiot, Sarah; Selent, Anne; Mankinen, Otto et al.

Part of Physical Chemistry, Chemical Physics - PCCP, p. 13164-13169, 2023

Article in journal

• DOI for SPICY: a method for single scan rotating frame relaxometry
• Download full text (pdf) of SPICY: a method for single scan rotating frame relaxometry

[¹⁸F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44

Cheung, Pierre; Amin, Mohammad A.; Zhang, Bo; Lechi, Francesco et al.

Part of Pharmaceutics, 2023

Article in journal

• DOI for [¹⁸F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44
• Download full text (pdf) of [¹⁸F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44

Electrochemical Palladium-Catalyzed Oxidative Carbonylation-Cyclization of Enallenols

Zhang, Jianwei; Das, Biswanath; Verho, Oscar; Bäckvall, Jan-E.

Part of Angewandte Chemie International Edition, 2022

Article in journal

• DOI for Electrochemical Palladium-Catalyzed Oxidative Carbonylation-Cyclization of Enallenols
• Download full text (pdf) of Electrochemical Palladium-Catalyzed Oxidative Carbonylation-Cyclization of Enallenols

Cobalt Electrocatalyst on Fluorine Doped Carbon Cloth - a Robust and Partially Regenerable Anode for Water Oxidation

Das, Biswanath; Toledo-Carrillo, Esteban Alejandro; Li, Lin; Ye, Fei et al.

Part of ChemCatChem, 2022

Article in journal

• DOI for Cobalt Electrocatalyst on Fluorine Doped Carbon Cloth - a Robust and Partially Regenerable Anode for Water Oxidation

Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule

Grinkevich, Vera V.; Vema, Aparna; Fawkner, Karin; Issaeva, Natalia et al.

Part of Frontiers in Molecular Biosciences, 2022

Article in journal

• DOI for Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule
• Download full text (pdf) of Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule

Bacterial type I signal peptidase inhibitors-Optimized hits from nature

Szalaj, Natalia; Benediktsdottir, Andrea; Rusin, Dominika; Karlén, Anders et al.

Part of European Journal of Medicinal Chemistry, 2022

Article in journal

• DOI for Bacterial type I signal peptidase inhibitors-Optimized hits from nature

2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands

Roy, Tamal; Petersen, Nadia N.; Gopalan, Greeshma; Gising, Johan et al.

Part of Bioorganic & Medicinal Chemistry, 2022

Article in journal

• DOI for 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands
• Download full text (pdf) of 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands

Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats

Peters, Karsten; Dahlgren, David; Egerszegi, Peter Pal; Lennernäs, Hans et al.

Part of International Journal of Molecular Sciences, 2022

Article in journal

• DOI for Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats
• Download full text (pdf) of Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats

Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

Luttens, Andreas; Gullberg, Hjalmar; Abdurakhmanov, Eldar; Vo, Duy Duc et al.

Part of Journal of the American Chemical Society, p. 2905-2920, 2022

Article in journal

• DOI for Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses
• Download full text (pdf) of Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

Dipolar Relaxation of Water Protons in the Vicinity of a Collagen-like Peptide

Karjalainen, Jouni; Henschel, Henning; Nissi, Mikko J.; Nieminen, Miika T. et al.

Part of Journal of Physical Chemistry B, p. 2538-2551, 2022

Article in journal

• DOI for Dipolar Relaxation of Water Protons in the Vicinity of a Collagen-like Peptide
• Download full text (pdf) of Dipolar Relaxation of Water Protons in the Vicinity of a Collagen-like Peptide

Spatial Distribution and Stability of Cholinesterase Inhibitory Protoberberine Alkaloids from Papaver setiferum

Safa, Neda; Trobec, Tomaz.; Holland, Darren C.; Slazak, Blazej et al.

Part of Journal of Natural Products, p. 215-224, 2022

Article in journal

• DOI for Spatial Distribution and Stability of Cholinesterase Inhibitory Protoberberine Alkaloids from Papaver setiferum
• Download full text (pdf) of Spatial Distribution and Stability of Cholinesterase Inhibitory Protoberberine Alkaloids from Papaver setiferum

Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats

Cano-Cebrian, Maria-Jose; Dahlgren, David; Kullenberg, Fredrik; Peters, Karsten et al.

Part of International Journal of Molecular Sciences, 2022

Article in journal

• DOI for Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats
• Download full text (pdf) of Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats

Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma

Khaled, Jaafar; Kopsida, Maria; Lennernäs, Hans; Heindryckx, Femke

Part of Cells, 2022

Article in journal

• DOI for Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma
• Download full text (pdf) of Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma

Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

Brem, Jürgen; Panduwawala, Tharindi; Hansen, Jon Ulf; Hewitt, Joanne et al.

Part of Nature Chemistry, p. 15-24, 2022

Article in journal

• DOI for Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)

Lu, Lu; Åkerbladh, Linda; Ahmad, Shabbir; Konda, Vivek et al.

Part of ACS - Infectious Diseases, p. 482-498, 2022

Article in journal

• DOI for Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)
• Download full text (pdf) of Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)

Towards the sustainable discovery and development of new antibiotics

Miethke, Marcus; Pieroni, Marco; Weber, Tilmann; Brönstrup, Mark et al.

Part of Nature Reviews Chemistry, p. 726-749, 2021

Article, review/survey

• DOI for Towards the sustainable discovery and development of new antibiotics

A Genetically Encoded Picolyl Azide for Improved Live Cell Copper Click Labeling

Meineke, Birthe; Heimgärtner, Johannes; Craig, Alexander J.; Landreh, Michael et al.

Part of Frontiers in Chemistry, 2021

Article in journal

• DOI for A Genetically Encoded Picolyl Azide for Improved Live Cell Copper Click Labeling
• Download full text (pdf) of A Genetically Encoded Picolyl Azide for Improved Live Cell Copper Click Labeling

Influence of Detergent and Lipid Composition on Reconstituted Membrane Proteins for Structural Studies

Mouhib, Mohammed; Benediktsdottir, Andrea; Svensson Nilsson, Caroline; Chi, Celestine N.

Part of ACS Omega, p. 24377-24381, 2021

Article in journal

• DOI for Influence of Detergent and Lipid Composition on Reconstituted Membrane Proteins for Structural Studies
• Download full text (pdf) of Influence of Detergent and Lipid Composition on Reconstituted Membrane Proteins for Structural Studies

The Impact of Ligand Carboxylates on Electrocatalyzed Water Oxidation

Das, Biswanath; Rahaman, Ahibur; Shatskiy, Andrey; Verho, Oscar et al.

Part of Accounts of Chemical Research, p. 3326-3337, 2021

Article, review/survey

• DOI for The Impact of Ligand Carboxylates on Electrocatalyzed Water Oxidation
• Download full text (pdf) of The Impact of Ligand Carboxylates on Electrocatalyzed Water Oxidation

Organic reactivity from mechanism to machine learning

Jorner, Kjell; Tomberg, Anna; Bauer, Christoph; Sköld, Christian et al.

Part of Nature Reviews Chemistry, p. 240-255, 2021

Article, review/survey

• DOI for Organic reactivity from mechanism to machine learning

Targeting the NS2B-NS3 protease of tick-borne encephalitis virus with pan-flaviviral protease inhibitors

Akaberi, Dario; Bahlstrom, Amanda; Chinthakindi, Praveen K.; Nyman, Tomas et al.

Part of Antiviral Research, 2021

Article in journal

• DOI for Targeting the NS2B-NS3 protease of tick-borne encephalitis virus with pan-flaviviral protease inhibitors

A Study of an 8-Aminoquinoline-Directed C(sp(2))-H Arylation Reaction on the Route to Chiral Cyclobutane Keto Acids from Myrtenal

Lati, Monireh Pourghasemi; Stahle, Jonas; Meyer, Michael; Verho, Oscar

Part of Journal of Organic Chemistry, p. 8527-8537, 2021

Article in journal

• DOI for A Study of an 8-Aminoquinoline-Directed C(sp(2))-H Arylation Reaction on the Route to Chiral Cyclobutane Keto Acids from Myrtenal
• Download full text (pdf) of A Study of an 8-Aminoquinoline-Directed C(sp(2))-H Arylation Reaction on the Route to Chiral Cyclobutane Keto Acids from Myrtenal

Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation

Benediktsdottir, Andrea; Lu, Lu; Cao, Sha; Zamaratski, Edouard et al.

Part of European Journal of Medicinal Chemistry, 2021

Article in journal

• DOI for Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation
• Download full text (pdf) of Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation

ENABLE: an engine for European antibacterial drug discovery and development

Olliver, Marie; Griestop, Laura; Hughes, Diarmaid; Belfrage, Anna Karin et al.

Part of Nature reviews. Drug discovery, p. 407-408, 2021

Article in journal

• DOI for ENABLE: an engine for European antibacterial drug discovery and development

Computational studies of molecular pre-organization through macrocyclization: Conformational distribution analysis of closely related non-macrocyclic and macrocyclic analogs

Olanders, Gustav; Brandt, Peter; Sköld, Christian; Karlen, Anders

Part of Bioorganic & Medicinal Chemistry, 2021

Article in journal

• DOI for Computational studies of molecular pre-organization through macrocyclization: Conformational distribution analysis of closely related non-macrocyclic and macrocyclic analogs
• Download full text (pdf) of Computational studies of molecular pre-organization through macrocyclization: Conformational distribution analysis of closely related non-macrocyclic and macrocyclic analogs

Investigation of the Deactivation and Reactivation Mechanism of a Heterogeneous Palladium(II) Catalyst in the Cycloisomerization of Acetylenic Acids by In Situ XAS

Yuan, Ning; Gudmundsson, Arnar; Gustafson, Karl P. J.; Oschmann, Michael et al.

Part of ACS Catalysis, p. 2999-3008, 2021

Article in journal

• DOI for Investigation of the Deactivation and Reactivation Mechanism of a Heterogeneous Palladium(II) Catalyst in the Cycloisomerization of Acetylenic Acids by In Situ XAS
• Download full text (pdf) of Investigation of the Deactivation and Reactivation Mechanism of a Heterogeneous Palladium(II) Catalyst in the Cycloisomerization of Acetylenic Acids by In Situ XAS

Enantioselective Synthesis of Atropisomeric Biaryls using Biaryl 2,5-Diphenylphospholanes as Ligands for Palladium-Catalysed Suzuki-Miyaura Reactions

Byrne, Liam; Sköld, Christian; Norrby, Per-Ola; Munday, Rachel H. et al.

Part of Advanced Synthesis and Catalysis, p. 259-267, 2021

Article in journal

• DOI for Enantioselective Synthesis of Atropisomeric Biaryls using Biaryl 2,5-Diphenylphospholanes as Ligands for Palladium-Catalysed Suzuki-Miyaura Reactions

The amino-terminal heptapeptide of the algesic substance P provides analgesic effect in relieving chronic neuropathic pain

Nyman, Julia; Guo, Ning; Sandström, Anja; Hallberg, Mathias et al.

Part of European Journal of Pharmacology, 2021

Article in journal

• DOI for The amino-terminal heptapeptide of the algesic substance P provides analgesic effect in relieving chronic neuropathic pain

Characterization of More Selective Central Nervous System Nrf2-Activating Novel Vinyl Sulfoximine Compounds Compared to Dimethyl Fumarate

Carlström, Karl E.; Chinthakindi, Praveen K.; Espinosa, Belen; Al Nimer, Faiez et al.

Part of NEUROTHERAPEUTICS, p. 1142-1152, 2020

Article in journal

• DOI for Characterization of More Selective Central Nervous System Nrf2-Activating Novel Vinyl Sulfoximine Compounds Compared to Dimethyl Fumarate
• Download full text (pdf) of Characterization of More Selective Central Nervous System Nrf2-Activating Novel Vinyl Sulfoximine Compounds Compared to Dimethyl Fumarate

Nanocatalysis Meets Biology

Verho, Oscar; Backvall, Jan-E.

Part of Nanoparticles in catalysis, p. 243-278, Springer Nature, 2020

Chapter in book

• DOI for Nanocatalysis Meets Biology

Phidianidine A and Synthetic Analogues as Naturally Inspired Marine Antifoulants

Labriere, Christophe; Elumalai, Vijayaragavan; Staffansson, Jannie; Cervin, Gunnar et al.

Part of Journal of Natural Products, p. 3413-3423, 2020

Article in journal

• DOI for Phidianidine A and Synthetic Analogues as Naturally Inspired Marine Antifoulants

Identification of a C2-symmetric diol based human immunodeficiency virus protease inhibitor targeting Zika virus NS2B-NS3 protease

Akaberi, Dario; Chinthakindi, Praveen K.; Båhlström, Amanda; Palanisamy, Navaneethan et al.

Part of Journal of Biomolecular Structure and Dynamics, p. 5526-5536, 2020

Article in journal

• DOI for Identification of a C2-symmetric diol based human immunodeficiency virus protease inhibitor targeting Zika virus NS2B-NS3 protease
• Download full text (pdf) of Identification of a C2-symmetric diol based human immunodeficiency virus protease inhibitor targeting Zika virus NS2B-NS3 protease

Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models

Dahlgren, David; Sjögren, Erik; Lennernäs, Hans

Part of ADMET & DMPK, p. 375-390, 2020

Article, review/survey

• DOI for Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models
• Download full text (pdf) of Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models

Turning Information Dissipation into Dissemination: Instagram as a Communication Enhancing Tool during the COVID-19 Pandemic and Beyond

Ye, Sofie; Hartmann, Rafael; Söderström, Marcus; Amin, Mohammad A. et al.

Part of Journal of Chemical Education, p. 3217-3222, 2020

Article in journal

• DOI for Turning Information Dissipation into Dissemination: Instagram as a Communication Enhancing Tool during the COVID-19 Pandemic and Beyond

Sulfadiazine Masquerading as a Natural Product from Scilla madeirensis (Scilloideae)

Robertson, Luke P.; Moodie, Lindon W. K.; Holland, Darren C.; Jandér, K. Charlotte et al.

Part of Journal of Natural Products, p. 1305-1308, 2020

Article in journal

• DOI for Sulfadiazine Masquerading as a Natural Product from Scilla madeirensis (Scilloideae)
• Download full text (pdf) of Sulfadiazine Masquerading as a Natural Product from Scilla madeirensis (Scilloideae)

The global preclinical antibacterial pipeline

Theuretzbacher, Ursula; Outterson, Kevin; Engel, Aleks; Karlen, Anders

Part of Nature Reviews Microbiology, p. 275-285, 2020

Article, review/survey

• DOI for The global preclinical antibacterial pipeline

Solid Phase Synthesis of Sulfonimidamide Pseudopeptides and Library Generation

Chinthakindi, Praveen K.; Benediktsdottir, Andrea; Arvidsson, Per I; Chen, Yantao et al.

Part of European Journal of Organic Chemistry, p. 3796-3807, 2020

Article in journal

• DOI for Solid Phase Synthesis of Sulfonimidamide Pseudopeptides and Library Generation
• Download full text (pdf) of Solid Phase Synthesis of Sulfonimidamide Pseudopeptides and Library Generation

Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors

Engen, Karin; Reddy Vanga, Sudarsana; Lundbäck, Thomas; Agalo, Faith et al.

Part of ChemistryOpen, p. 325-337, 2020

Article in journal

• DOI for Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors
• Download full text (pdf) of Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors

Macrocyclic Peptidomimetics as Inhibitors of Insulin-Regulated Aminopeptidase (IRAP)

Barlow, Nicholas; Reddy Vanga, Sudarsana; Sävmarker, Jonas; Sandström, Anja et al.

Part of RSC Medicinal chemistry, p. 234-244, 2020

Article in journal

• DOI for Macrocyclic Peptidomimetics as Inhibitors of Insulin-Regulated Aminopeptidase (IRAP)

Conformational Analysis of Macrocycles: Comparing General and Specialized Methods

Olanders, Gustav; Alogheli, Hiba; Brandt, Peter; Karlén, Anders

Part of Journal of Computer-Aided Molecular Design, p. 231-252, 2020

Article in journal

• DOI for Conformational Analysis of Macrocycles: Comparing General and Specialized Methods
• Download full text (pdf) of Conformational Analysis of Macrocycles: Comparing General and Specialized Methods

High affinity rigidified AT(2) receptor ligands with indane scaffolds

Wallinder, Charlotta; Sköld, Christian; Sundholm, Sara; Guimond, Marie-Odile et al.

Part of MedChemComm, p. 2146-2160, 2019

Article in journal

• DOI for High affinity rigidified AT(2) receptor ligands with indane scaffolds
• Download full text (pdf) of High affinity rigidified AT(2) receptor ligands with indane scaffolds

Relative Strength of Common Directing Groups in Palladium-Catalyzed Aromatic C-H Activation

Tomberg, Anna; Muratore, Michael Eric; Johansson, Magnus Jan; Terstiege, Ina et al.

Part of iScience, p. 373-+, 2019

Article in journal

• DOI for Relative Strength of Common Directing Groups in Palladium-Catalyzed Aromatic C-H Activation
• Download full text (pdf) of Relative Strength of Common Directing Groups in Palladium-Catalyzed Aromatic C-H Activation

Thiomethylation, Nitro Reduction and Tandem Reduction/SMe Insertion of Nitrogen Heterocycles Using BF₃⦁SMe₂

Söderström, Marcus; Zamaratski, Edouard; Odell, Luke R.

Part of European Journal of Organic Chemistry, p. 5402-5408, 2019

Article in journal

• DOI for Thiomethylation, Nitro Reduction and Tandem Reduction/SMe Insertion of Nitrogen Heterocycles Using BF₃⦁SMe₂
• Download full text (pdf) of Thiomethylation, Nitro Reduction and Tandem Reduction/SMe Insertion of Nitrogen Heterocycles Using BF₃⦁SMe₂

Synthesis and preclinical evaluation of the CRTH2 antagonist [¹¹C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass

Eriksson, Jonas; Roy, Tamal; Sawadjoon, Supaporn; Bachmann, Kim et al.

Part of Nuclear Medicine and Biology, p. 1-10, 2019

Article in journal

• DOI for Synthesis and preclinical evaluation of the CRTH2 antagonist [¹¹C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass
• Download full text (pdf) of Synthesis and preclinical evaluation of the CRTH2 antagonist [¹¹C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass

Synthesis of Sulfonimidamide-Based Amino Acid Building Blocks with Orthogonal Protecting Groups

Chinthakindi, Praveen K.; Benediktsdottir, Andrea; Ibrahim, Ayah; Wared, Atta et al.

Part of European Journal of Organic Chemistry, p. 1045-1057, 2019

Article in journal

• DOI for Synthesis of Sulfonimidamide-Based Amino Acid Building Blocks with Orthogonal Protecting Groups

From the Anti-Nociceptive Substance P Metabolite Substance P (1-7) to Small Peptidomimetics

Hallberg, Mathias; Sandström, Anja

Part of Current protein and peptide science, p. 1038-1048, 2018

Article, review/survey

• DOI for From the Anti-Nociceptive Substance P Metabolite Substance P (1-7) to Small Peptidomimetics

Sulfonyl Fluorides (SFs): More Than Click Reagents?

Chinthakindi, Praveen K.; Arvidsson, Per I.

Part of European Journal of Organic Chemistry, p. 3648-3666, 2018

Article, review/survey

• DOI for Sulfonyl Fluorides (SFs): More Than Click Reagents?

Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase

Szałaj, Natalia; Lu, Lu; Benediktsdottir, Andrea; Zamaratski, Edouard et al.

Part of European Journal of Medicinal Chemistry, p. 1346-1360, 2018

Article in journal

• DOI for Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase

An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice

Skogh, Anna; Lesniak, Anna; Sköld, Christian; Karlgren, Maria et al.

Part of Bioorganic & Medicinal Chemistry Letters, p. 2446-2450, 2018

Article in journal

• DOI for An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice

Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold

Belfrage, Anna Karin; Abdurakhmanov, Eldar; Åkerblom, Eva; Brandt, Peter et al.

Part of European Journal of Medicinal Chemistry, p. 453-464, 2018

Article in journal

• DOI for Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold

Impact of N-methylation of the substance P 1-7 amide on anti-allodynic effect in mice after peripheral administration

Skogh, Anna; Lesniak, Anna; Gaugaz, Fabienne Z.; Svensson, Richard et al.

Part of European Journal of Pharmaceutical Sciences, p. 533-540, 2017

Article in journal

• DOI for Impact of N-methylation of the substance P 1-7 amide on anti-allodynic effect in mice after peripheral administration

Importance of N-and C-terminal residues of substance P 1-7 for alleviating allodynia in mice after peripheral administration

Skogh, Anna; Lesniak, Anna; Gaugaz, Fabienne Z.; Svensson, Richard et al.

Part of European Journal of Pharmaceutical Sciences, p. 345-351, 2017

Article in journal

• DOI for Importance of N-and C-terminal residues of substance P 1-7 for alleviating allodynia in mice after peripheral administration

Palladium-Catalyzed Aminocarbonylation in Solid-Phase Peptide Synthesis: A Method for Capping, Cyclization, and Isotope Labeling

Skogh, Anna; Friis, Stig D.; Skrydstrup, Troels; Johansson, Anja

Part of Organic Letters, p. 2873-2876, 2017

Article in journal

• DOI for Palladium-Catalyzed Aminocarbonylation in Solid-Phase Peptide Synthesis: A Method for Capping, Cyclization, and Isotope Labeling

Predicting the Rate of Skin Penetration Using an Aggregated Conformal Prediction Framework

Lindh, Martin; Karlén, Anders; Norinder, Ulf

Part of Molecular Pharmaceutics, p. 1571-1576, 2017

Article in journal

• DOI for Predicting the Rate of Skin Penetration Using an Aggregated Conformal Prediction Framework

Docking of Macrocycles: Comparing Rigid and Flexible Docking in Glide

Alogheli, Hiba; Olanders, Gustav; Schaal, Wesley; Brandt, Peter et al.

Part of Journal of Chemical Information and Modeling, p. 190-202, 2017

Article in journal

• DOI for Docking of Macrocycles: Comparing Rigid and Flexible Docking in Glide

Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)

De Rosa, Maria; Lu, Lu; Zamaratski, Edouard; Szałaj, Natalia et al.

Part of Bioorganic & Medicinal Chemistry, p. 897-911, 2017

Article in journal

• DOI for Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)
• Download full text (pdf) of Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)

Microwave-Assisted Branching Cascades: A Route to Diverse 3,4-Dihydroquinazolinone-Embedded Polyheterocyclic Scaffolds

Sawant, Rajiv T.; Stevens, Marc Y.; Sköld, Christian; Odell, Luke R.

Part of Organic Letters, p. 5392-5395, 2016

Article in journal

• DOI for Microwave-Assisted Branching Cascades: A Route to Diverse 3,4-Dihydroquinazolinone-Embedded Polyheterocyclic Scaffolds

The Innovative Medicines Initiative's New Drugs for Bad Bugs programme: European public-private partnerships for the development of new strategies to tackle antibiotic resistance

Kostyanev, T.; Bonten, M. J. M.; O'Brien, S.; Steel, H. et al.

Part of Journal of Antimicrobial Chemotherapy, p. 290-295, 2016

Article, review/survey

• DOI for The Innovative Medicines Initiative's New Drugs for Bad Bugs programme: European public-private partnerships for the development of new strategies to tackle antibiotic resistance

Structural determinants of subtype selectivity and functional activity of angiotensin II receptors

Sallander, Jessica; Wallinder, Charlotta; Hallberg, Anders; Åqvist, Johan et al.

Part of Bioorganic & Medicinal Chemistry Letters, p. 1355-1359, 2016

Article in journal

• DOI for Structural determinants of subtype selectivity and functional activity of angiotensin II receptors

Discovery of pyrazinone based compounds that potently inhibit the drug resistant enzyme variant R155K of the hepatitis C virus NS3 protease

Belfrage, Anna Karin; Abdurakhmanov, Eldar; Åkerblom, Eva; Brandt, Peter et al.

Part of Bioorganic & Medicinal Chemistry, p. 2603-2620, 2016

Article in journal

• DOI for Discovery of pyrazinone based compounds that potently inhibit the drug resistant enzyme variant R155K of the hepatitis C virus NS3 protease

Palladium-Catalyzed Carbonylation of Aryl Iodides with Sulfinamides

Belfrage, Anna Karin; Wakchaure, Prasad; Larhed, Mats; Sandström, Anja

Part of European Journal of Organic Chemistry, p. 7069-7074, 2015

Article in journal

• DOI for Palladium-Catalyzed Carbonylation of Aryl Iodides with Sulfinamides

Virtual Screening for Transition State Analogue Inhibitors of IRAP Based on Quantum Mechanically Derived Reaction Coordinates

Svensson, Fredrik; Engen, Karin; Lundbäck, Thomas; Larhed, Mats et al.

Part of Journal of Chemical Information and Modeling, p. 1984-1993, 2015

Article in journal

• DOI for Virtual Screening for Transition State Analogue Inhibitors of IRAP Based on Quantum Mechanically Derived Reaction Coordinates

Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents

Russo, Francesco; Gising, Johan; Åkerbladh, Linda; Roos, Annette K. et al.

Part of ChemistryOpen, p. 342-362, 2015

Article in journal

• DOI for Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents
• Download full text (pdf) of Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents

Preclinical Characterization of Acyl Sulfonimidamides: Potential Carboxylic Acid Bioisosteres with Tunable Properties

Borhade, Sanjay R.; Svensson, Richard; Brandt, Peter; Artursson, Per et al.

Part of ChemMedChem, p. 455-460, 2015

Article in journal

• DOI for Preclinical Characterization of Acyl Sulfonimidamides: Potential Carboxylic Acid Bioisosteres with Tunable Properties

Toward a Benchmarking Data Set Able to Evaluate Ligand- and Structure-based Virtual Screening Using Public HTS Data

Lindh, Martin; Svensson, Fredrik; Schaal, Wesley; Zhang, Jin et al.

Part of Journal of Chemical Information and Modeling, p. 343-353, 2015

Article in journal

• DOI for Toward a Benchmarking Data Set Able to Evaluate Ligand- and Structure-based Virtual Screening Using Public HTS Data

Small constrained SP_1-7 analogues bind to a unique site and promote anti-allodynic effects following systemic injection in mice

Jonsson, Anna; Fransson, Rebecca; Haramaki, Yutaka; Skogh, Anna et al.

Part of Neuroscience, p. 112-119, 2015

Article in journal

• DOI for Small constrained SP_1-7 analogues bind to a unique site and promote anti-allodynic effects following systemic injection in mice

Efficient and Selective Palladium-Catalysed C-3 Urea Couplings to 3,5-Dichloro-2(1H)-pyrazinones

Belfrage, Anna Karin; Gising, Johan; Svensson, Fredrik; Åkerblom, Eva et al.

Part of European Journal of Organic Chemistry, p. 978-986, 2015

Article in journal

• DOI for Efficient and Selective Palladium-Catalysed C-3 Urea Couplings to 3,5-Dichloro-2(1H)-pyrazinones

Synthesis of Vinyl- and Aryl–Acyl Sulfonimidamides Through Pd-Catalyzed Carbonylation Using Mo(CO)₆ as ex situ CO Source

Wakchaure, Prasad; Borhade, Sanjay; Sandström, Anja; Arvidsson, Per

Part of European Journal of Organic Chemistry, p. 213-219, 2015

Article in journal

• DOI for Synthesis of Vinyl- and Aryl–Acyl Sulfonimidamides Through Pd-Catalyzed Carbonylation Using Mo(CO)₆ as ex situ CO Source

Phototriggerable peptidomimetics for the inhibition of Mycobacterium turberculosis ribonucleotide reductase by targeting protein-protein binding

Karlsson, Christoffer; Blom, Magnus; Johansson, Miranda; Jansson, Anna M. et al.

Part of Organic and biomolecular chemistry, p. 2612-2621, 2015

Article in journal

• DOI for Phototriggerable peptidomimetics for the inhibition of Mycobacterium turberculosis ribonucleotide reductase by targeting protein-protein binding

Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT2 Receptor Ligands

Wallinder, Charlotta; Sköld, Christian; Botros, Milad; Guimond, Marie-Odile et al.

Part of ACS Medicinal Chemistry Letters, p. 178-182, 2015

Article in journal

• DOI for Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT2 Receptor Ligands