Biomarkers in predicting dementia, falls and fractures in a cohort of very old men
In Elisabeth Hellquist PhD project, we focus on the early diagnosis of Alzheimer's disease (AD), which is crucial for effective intervention strategies. Using the Uppsala Longitudinal Study of Adult Men (ULSAM), we conduct comprehensive examinations of new biomarkers and prodromal AD phenotypes to improve diagnostic precision and predictive accuracy
Details
- Funder: Geriatriska fonden, Thuréus stiftelse för främjande av geriatrisk forskning, Konung Gustaf V:S och Drottning Victorias Frimurarestiftelse
Studies of plasma phosphorylated tau as a biomarker for of Alzheimer's disease
Recent scientific advancements have highlighted the potential of plasma phosphorylated tau (p-tau) levels as robust biomarkers for the early diagnosis of Alzheimer's disease, presenting a promising alternative to the traditional cerebrospinal fluid analysis. This approach offers several advantages, including its non-invasive nature, overcoming the limitations associated with lumbar puncture. Using data from the Uppsala Longitudinal Study of Adult Men (ULSAM) we are aiming to elucidate the correlation between plasma p-tau levels and cognitive function/dementia in elderly men. Through the analysis of almost 1000 stored plasma samples collected in ULSAM at 82, 88 and 93 years of age and comprehensive assessments including lumbar puncture and brain imaging, we seek to deepen our understanding of the predictive value of plasma biomarkers for AD in older individuals, thus potentially transforming early diagnosis and intervention strategies.
Motoric cognitive risk syndrome in prediction of dementia and falls
The potential pre-clinical state ”subjective cognitive impairment” (SCI) may precede dementia with 10-15 years. However, a majority of elderly persons with memory complaints will not progress to AD dementia. A novel approach integrating SCI with slowed gait, termed "motoric cognitive risk syndrome" (MCR), has shown promise as an early indicator of AD pathology. Exploring the intersection of MCR with adverse outcomes such as falls, fractures, and mortality in the geriatric population is paramount to advancing our understanding of prodromal dementia and optimizing geriatric care strategies. Additionally, we will investigate to what extent factors such as low bone mineral density and skeletal muscle mass may contribute to these outcomes in elderly men, with and without dementia.