Doctoral thesis and Research articles

Astrocytes in Alzheimer’s disease: Exploring the impact of amyloid-β pathology on neurotoxicity, metabolism and inflammation.

Beretta, Chiara

2024

Doctoral thesis, comprehensive summary

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A stargazer's guide to neurodegeneration: Astrocytes' role in the propagation of pathological proteins

Mothes, Tobias

2024

Doctoral thesis, comprehensive summary

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Harnessing the molecular Trojan horse: Evaluating properties of preclinical Aβ immunoPET radioligands for optimized brain delivery via the transferrin receptor

Bonvicini, Gillian

2023

Doctoral thesis, comprehensive summary

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One-click away from higher contrast: Improvements to peripheral clearance for same-day immunoPET in Alzheimer’s disease

Schlein, Eva

2023

Doctoral thesis, comprehensive summary

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Visualising neurodegeneration in the living brain: Preclinical evaluation of PET radioligands

Xiong, Mengfei

2023

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Factors influencing transferrin receptor-mediated brain delivery: Evaluating preclinical antibody-based proteins for PET imaging in Alzheimer’s disease

Faresjö Melander, Rebecca

2023

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Pathophysiological effects of alpha-synuclein on SNARE complex proteins in models of alpha-synucleinopathies

Brolin, Emma

2022

Doctoral thesis, comprehensive summary

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Ex‘PLA’ining the progression of pathological proteins in Alzheimer’s and Parkinson’s diseases: see(d)ing is believing

Behere, Anish

2022

Doctoral thesis, comprehensive summary

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CRISPR/Cas9-based therapies and the role of astrocytes in Alzheimer’s disease and Parkinson’s disease

Konstantinidis, Evangelos

2022

Doctoral thesis, comprehensive summary

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Brain distribution of a bispecific antibody targeting Aβ

Tobias, Gustavsson

2022

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Characterization of the novel “Uppsala mutation” causing a familial form of early onset Alzheimer’s disease

Pagnon de la Vega, María

2021

Doctoral thesis, comprehensive summary

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Preclinical PET imaging and therapy of Alzheimer's disease

Meier, Silvio R.

2021

Doctoral thesis, comprehensive summary

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The role of glial cells in alpha-synuclein pathology: Focus on degradation, cell-to-cell propagation and inflammation

Rostami, Jinar

2020

Doctoral thesis, comprehensive summary

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Characterization of Physiological and Pathological Alpha-Synuclein: Implications for Parkinson’s Disease and Related Disorders

Almandoz Gil, Leire

2018

Doctoral thesis, comprehensive summary

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Cellular responses to amyloid-beta protofibrils: Focus on astrocytes, extracellular vesicles and antibody treatment

Nikitidou, Elisabeth

2018

Doctoral thesis, comprehensive summary

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Preclinical PET imaging of Alzheimer's disease progression

Fang, Xiaotian T.

2017

Doctoral thesis, comprehensive summary

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Alpha-Synuclein Oligomers: Cellular Mechanisms and Aspects of Antibody Treatment

Gustafsson, Gabriel

2017

Doctoral thesis, comprehensive summary

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Amyloid-β Protofibrils in Alzheimer´s Disease: Focus on Antibodies, Inflammation and Astrocytes

Söllvander, Sofia

2015

Doctoral thesis, comprehensive summary

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Therapeutic and functional studies in animal models of Alzheimer's disease

Gumucio, Astrid

2014

Doctoral thesis, comprehensive summary

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Studies of α-synuclein Oligomers-with Relevance to Lewy Body Disorders

Fagerqvist, Therese

2013

Doctoral thesis, comprehensive summary

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Characterization of α-synuclein oligomers: Implications for Lewy Body Disorders

Näsström, Thomas

2011

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Heparan Sulfate in the Amyloidosis and Inflammation of Alzheimer’s Disease

O'Callaghan, Paul

2011

Doctoral thesis, comprehensive summary

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Aβ Conformation Dependent Antibodies and Alzheimer's Disease

Sehlin, Dag

2010

Doctoral thesis, comprehensive summary

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Modeling Amyloid-β Pathology in Alzheimer’s Disease Using the Arctic Mutation

Philipson, Ola

2010

Doctoral thesis, comprehensive summary

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Soluble amyloid-β aggregates in Alzheimer’s disease

Englund, Hillevi

2009

Doctoral thesis, comprehensive summary

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Targeting Early Stages of Alzheimer’s Disease in a Transgenic Model

Lord, Anna

2009

Doctoral thesis, comprehensive summary

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Molecular Mechanisms of Frontotemporal Lobar Degeneration

Skoglund, Lena

2009

Doctoral thesis, comprehensive summary

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Genetic Studies of Alzheimer's Disease

Blom, Elin

2008

Doctoral thesis, comprehensive summary

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Amyloid-β Protofibril Formation and Neurotoxicity: Implications for Alzheimer’s Disease

Johansson, Ann-Sofi

2007

Doctoral thesis, comprehensive summary

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Pathogenic Mechanisms of the Arctic Alzheimer Mutation

Sahlin, Charlotte

2007

Doctoral thesis, comprehensive summary

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Amyloid precursor protein derivatives differentially alter the microRNA cargo of astrocyte-derived extracellular vesicles

Chu, Aimee J.; Erlandsson, Anna; Williams, Joanna M.

Part of Neuroscience, p. 22-36, 2026

Article in journal

• DOI for Amyloid precursor protein derivatives differentially alter the microRNA cargo of astrocyte-derived extracellular vesicles

Evaluating the impact of age and treatment on neuroinflammation-related proteins in mouse models of proteinopathies

Dahlén, Amelia; Roshanbin, Sahar; Bucher, Nadja M.; Sehlin, Dag et al.

Part of Experimental Neurology, 2026

Article in journal

• DOI for Evaluating the impact of age and treatment on neuroinflammation-related proteins in mouse models of proteinopathies
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Zombosomes are anucleated cell couriers that spread α-synuclein pathology

Dakhel, Abdulkhalek; Beretta, Chiara; Mothes, Tobias; Hakhverdyan, Sona et al.

Part of Cell Reports, 2026

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• DOI for Zombosomes are anucleated cell couriers that spread α-synuclein pathology
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Exposure to fibrillar proteins leads to widespread infiltration but only mild tau pathology in cortical organoids

Dakhel, Abdulkhalek; Mothes, Tobias; Eltom, Khalid; Michno, Wojciech et al.

Part of iScience, 2026

Article in journal

• DOI for Exposure to fibrillar proteins leads to widespread infiltration but only mild tau pathology in cortical organoids
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Diagnostic biomarkers for α-synucleinopathies- state of the art and future developments: a systematic review

Donadio, V.; Ingelsson, Martin; Rizzo, G.; Furia, A. et al.

Part of Molecular Neurodegeneration, 2026

Article, review/survey

• DOI for Diagnostic biomarkers for α-synucleinopathies- state of the art and future developments: a systematic review
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Targeted CSF metabolomics and conformal prediction improve diagnostic accuracy of normal pressure hydrocephalus

Hofling, Ulrika; Jakobsson, Jenny; Erngren, Ida; Ekman, Oskar et al.

Part of Fluids and Barriers of the CNS, 2026

Article in journal

• DOI for Targeted CSF metabolomics and conformal prediction improve diagnostic accuracy of normal pressure hydrocephalus
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MALDI mass spectrometry imaging (MSI) reveals molecular and structural heterogeneity of amyloid-β in sporadic Alzheimer's disease and Down syndrome

Minta, Karolina; Söderberg, Linda; Gkanatsiou, Eleni; Johannesson, Malin et al.

Part of Acta neuropathologica communications, 2026

Article in journal

• DOI for MALDI mass spectrometry imaging (MSI) reveals molecular and structural heterogeneity of amyloid-β in sporadic Alzheimer's disease and Down syndrome
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α-Synuclein purification significantly impacts seed amplification assay performance and consistency

Al-Azzawi, Zaid A. M.; Silver, Nicholas R. G.; Mehra, Surabhi; Niu, Simeng et al.

Part of Acta neuropathologica communications, 2025

Article in journal

• DOI for α-Synuclein purification significantly impacts seed amplification assay performance and consistency
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Soluble cerebral Aβ protofibrils link Aβ plaque pathology to changes in CSF Aβ₄₂/Aβ₄₀ ratios, neurofilament light and tau in Alzheimer’s disease model micece

Andersson, Emelie; Lindblom, Nils; Janelidze, Shorena; Salvadó, Gemma et al.

Part of Nature Aging, p. 366-375, 2025

Article in journal

• DOI for Soluble cerebral Aβ protofibrils link Aβ plaque pathology to changes in CSF Aβ₄₂/Aβ₄₀ ratios, neurofilament light and tau in Alzheimer’s disease model micece
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Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery

Beretta, Chiara; Dakhel, Abdulkhalek; Eltom, Khalid; Rosqvist, Fredrik et al.

Part of Journal of Neuroinflammation, 2025

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• DOI for Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery
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High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose

Bonvicini, Gillian; Singh, Sunitha; Sandersjoo, Lisa; Dallas, Tiffany et al.

Part of Fluids and Barriers of the CNS, 2025

Article in journal

• DOI for High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose
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The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo

Bonvicini, Gillian; Singh, Sunitha; Sandersjoo, Lisa; Sehlin, Dag et al.

Part of Fluids and Barriers of the CNS, 2025

Article in journal

• DOI for The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo
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Machine learning in Alzheimer's disease genetics

Bracher-Smith, Matthew; Melograna, Federico; Ulm, Brittany; Bellenguez, Celine et al.

Part of Nature Communications, 2025

Article in journal

• DOI for Machine learning in Alzheimer's disease genetics
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PET imaging of TREM2 in amyloid-beta induced neuroinflammation

Dahlén, Amelia; Roshanbin, Sahar; Aguilar, Ximena; Bucher, Nadja et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 4320-4333, 2025

Article in journal

• DOI for PET imaging of TREM2 in amyloid-beta induced neuroinflammation
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Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration

de la Rosa, Andrés; Metzendorf, Nicole G.; Efverström, Jonathan; Godec, Ana et al.

Part of Neurotherapeutics, 2025

Article in journal

• DOI for Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration
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Development of a toxin-selective immunotracer for in vivo detection of Clostridioides difficile infection by immunoPET

Gonzalez-Arjona, Mario; Cusso, Lorena; Alcala, Luis; Gonzalez, Maria Isabel et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2025

Article in journal

• DOI for Development of a toxin-selective immunotracer for in vivo detection of Clostridioides difficile infection by immunoPET
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Protocol for immunodetection of α-synuclein pathology in paraffin-embedded liver tissues from murine models of Parkinson's disease

Hallbeck, Martin; Ntzouni, Maria; Ingelsson, Martin; Reyes, Juan F.

Part of STAR Protocols, 2025

Article in journal

• DOI for Protocol for immunodetection of α-synuclein pathology in paraffin-embedded liver tissues from murine models of Parkinson's disease
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Plasma p-tau ₂₁₇ correlates strongly with cerebrospinal fluid Aβ ₄₂ and increases over a ten-year period in amyloid-positive, non-demented very old men

Hellquist, Elisabeth; Janelidze, Shorena; Weidung, Bodil; Franzon, Kristin et al.

Part of Journal of Alzheimer's Disease, p. 1778-1789, 2025

Article in journal

• DOI for Plasma p-tau ₂₁₇ correlates strongly with cerebrospinal fluid Aβ ₄₂ and increases over a ten-year period in amyloid-positive, non-demented very old men
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DNA methylation patterns contribute to changes of cellular differentiation pathways in leukocytes with LOY from patients with Alzheimers disease

Jakalski, Marcin; Bruhn-Olszewska, Bożena; Rychlicka-Buniowska, Edyta; Davies, Hanna et al.

Part of Cellular and Molecular Life Sciences (CMLS), 2025

Article in journal

• DOI for DNA methylation patterns contribute to changes of cellular differentiation pathways in leukocytes with LOY from patients with Alzheimers disease
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Dual-ligand fluorescence microscopy enables chronological and spatial histological assignment of distinct amyloid-β deposits

Klingstedt, Therése; Shirani, Hamid; Parvin, Farjana; Nyström, Sofie et al.

Part of Journal of Biological Chemistry, 2025

Article in journal

• DOI for Dual-ligand fluorescence microscopy enables chronological and spatial histological assignment of distinct amyloid-β deposits
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Chemical imaging delineates Aβ plaque polymorphism across the Alzheimer’s disease spectrum

Koutarapu, Srinivas; Ge, Junyue; Dulewicz, Maciej; Srikrishna, Meera et al.

Part of Nature Communications, 2025

Article in journal

• DOI for Chemical imaging delineates Aβ plaque polymorphism across the Alzheimer’s disease spectrum
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X-chromosome-wide association study for Alzheimer's disease

Le Borgne, Julie; Gomez, Lissette; Heikkinen, Sami; Amin, Najaf et al.

Part of Molecular Psychiatry, p. 2335-2346, 2025

Article in journal

• DOI for X-chromosome-wide association study for Alzheimer's disease
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Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues

Lee, Yea-Rin; Kaya, Ibrahim; Wik, Elin; Baijnath, Sooraj et al.

Part of Analytical Chemistry, p. 1338-1346, 2025

Article in journal

• DOI for Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues
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Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine

Lopes van den Broek, Sara; Eriksson, Jonas; Yang, Qiaojun; Bucher, Nadja M. et al.

Part of Translational Neurodegeneration, 2025

Article in journal

• DOI for Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine
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4R-tau seeding activity reveals molecular subtypes in progressive supranuclear palsy

Martinez-Valbuena, Ivan; Lee, Seojin; Santamaria, Enrique; Fernandez-Irigoyen, Joaquin et al.

Part of Nature Communications, 2025

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• DOI for 4R-tau seeding activity reveals molecular subtypes in progressive supranuclear palsy
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Somatostatin therapy, neprilysin activation, and amyloid beta reduction: A novel approach for Alzheimer's treatment

Metzendorf, Nicole G.; Godec, Ana; Petrovic, Alex; Chourlia, Aikaterini et al.

Part of Biomedicine and Pharmacotherapy, 2025

Article in journal

• DOI for Somatostatin therapy, neprilysin activation, and amyloid beta reduction: A novel approach for Alzheimer's treatment
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Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates

Metzendorf, Nicole G.; Sehlin, Dag; Hultqvist, Greta

Part of Frontiers in Neuroscience, 2025

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• DOI for Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates
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Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations

Nicolas, Aude; Sherva, Richard; Grenier-Boley, Benjamin; Kim, Yoontae et al.

Part of Nature Genetics, 2025

Article in journal

• DOI for Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations
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Loss of Y chromosome in Alzheimer's patients co-occurs with somatic mutations beyond CHIP drivers

Rychlicka-Buniowska, Edyta; Sarkisyan, Daniil; Horbacz, Monika; Bruhn-Olszewska, Bożena et al.

Part of Life Science Alliance, 2025

Article in journal

• DOI for Loss of Y chromosome in Alzheimer's patients co-occurs with somatic mutations beyond CHIP drivers
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Fluorine-18 ImmunoPET Imaging of Antibody Brain Kinetics and Amyloid-Beta Pathology

Schlein, Eva; Lopes van den Broek, Sara; Dallas, Tiffany; Andersson, Ken G. et al.

Part of ACS Pharmacology & Translational Science, p. 2804-2813, 2025

Article in journal

• DOI for Fluorine-18 ImmunoPET Imaging of Antibody Brain Kinetics and Amyloid-Beta Pathology
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Brain-penetrating peptide and antibody radioligands for proof-of-concept PET imaging of fibrin in Alzheimer's disease

Sehlin, Dag; Aguilar, Ximena; Cortes-Canteli, Marta; Syvänen, Stina et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2025

Article in journal

• DOI for Brain-penetrating peptide and antibody radioligands for proof-of-concept PET imaging of fibrin in Alzheimer's disease
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Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease

Sehlin, Dag; Hultqvist, Greta; Michno, Wojciech; Aguilar, Ximena et al.

Part of The Journal of Prevention of Alzheimer's Disease, 2025

Article in journal

• DOI for Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease
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A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology

Sehlin, Dag; Roshanbin, Sahar; Zachrisson, Olof; Ingelsson, Martin et al.

Part of Neurotherapeutics, 2025

Article in journal

• DOI for A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology
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Molecular Therapeutics in Development to Treat Alzheimer's Disease

Tartaglia, Maria Carmela; Ingelsson, Martin

Part of Molecular Diagnosis & Therapy, p. 9-24, 2025

Article in journal

• DOI for Molecular Therapeutics in Development to Treat Alzheimer's Disease
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Distinct inflammatory profiles in young-onset versus late-onset Alzheimer's disease

Thapa, Simrika; Anastassiadis, Chloe; Vasilevskaya, Anna; Taghdiri, Foad et al.

Part of Alzheimer's & Dementia, 2025

Article in journal

• DOI for Distinct inflammatory profiles in young-onset versus late-onset Alzheimer's disease
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Cryo-EM studies of amyloid-β fibrils from human and murine brains carrying the Uppsala APP mutation (Δ690-695)

Zielinski, Mara; Peralta Reyes, Fernanda S.; Gremer, Lothar; Sommerhage, Simon et al.

Part of Acta neuropathologica communications, 2025

Article in journal

• DOI for Cryo-EM studies of amyloid-β fibrils from human and murine brains carrying the Uppsala APP mutation (Δ690-695)
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Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms

Beretta, Chiara; Svensson, Elina; Dakhel, Abdulkhalek; Zyśk, Marlena et al.

Part of Molecular and Cellular Neuroscience, 2024

Article in journal

• DOI for Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms
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Comparing in vitro affinity measurements of antibodies to TfR1: Surface plasmon resonance versus on-cell affinity

Bonvicini, Gillian; Singh, Sunitha; Nygren, Patrik; Xiong, Mengfei et al.

Part of Analytical Biochemistry, 2024

Article in journal

• DOI for Comparing in vitro affinity measurements of antibodies to TfR1: Surface plasmon resonance versus on-cell affinity
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Active CNS delivery of oxycodone in healthy and endotoxemic pigs

Bällgren, Frida; Bergfast, Tilda; Ginosyan, Aghavni; Mahajan, Jessica et al.

Part of Fluids and Barriers of the CNS, 2024

Article in journal

• DOI for Active CNS delivery of oxycodone in healthy and endotoxemic pigs
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Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment

Eltom, Khalid; Mothes, Tobias; Libard, Sylwia; Ingelsson, Martin et al.

Part of Acta neuropathologica communications, 2024

Article in journal

• DOI for Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment
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Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β

Faresjö, Rebecca; Sjöström, Elisabet O.; Dallas, Tiffany; Berglund, Magnus M. et al.

Part of mAbs, 2024

Article in journal

• DOI for Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β
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Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging

Gustavsson, Tobias; Herth, Matthias M.; Sehlin, Dag; Syvänen, Stina

Part of Upsala Journal of Medical Sciences, 2024

Article in journal

• DOI for Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging
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Accumulation of alpha-synuclein pathology in the liver exhibits post-translational modifications associated with Parkinson's disease

Hallbeck, Martin; Ekmark-Lewén, Sara; Kahle, Philipp J.; Ingelsson, Martin et al.

Part of iScience, 2024

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• DOI for Accumulation of alpha-synuclein pathology in the liver exhibits post-translational modifications associated with Parkinson's disease
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Lecanemab demonstrates highly selective binding to Aβ protofibrils isolated from Alzheimer's disease brains

Johannesson, Malin; Soderberg, Linda; Zachrisson, Olof; Fritz, Nicolas et al.

Part of Molecular and Cellular Neuroscience, 2024

Article in journal

• DOI for Lecanemab demonstrates highly selective binding to Aβ protofibrils isolated from Alzheimer's disease brains
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Association of MGMT and BIN1 genes with Alzheimer's disease risk across sex and APOE ε4 status

Le Borgne, Julie; Amouyel, Philippe; Andreassen, Ole; Frikke-Schmidt, Ruth et al.

Part of Alzheimer's & Dementia, p. 2282-2284, 2024

Article in journal

• DOI for Association of MGMT and BIN1 genes with Alzheimer's disease risk across sex and APOE ε4 status
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Spatial Neurolipidomics at the Single Amyloid-β Plaque Level in Postmortem Human Alzheimer's Disease Brain

Michno, Wojciech; Bowman, Andrew; Jha, Durga; Minta, Karolina et al.

Part of ACS Chemical Neuroscience, p. 877-888, 2024

Article in journal

• DOI for Spatial Neurolipidomics at the Single Amyloid-β Plaque Level in Postmortem Human Alzheimer's Disease Brain
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Tau processing and tau-mediated inflammation differ in human APOEε2 and APOEε4 astrocytes

Mothes, Tobias; Konstantinidis, Evangelos; Eltom, Khalid; Dakhel, Abdulkhalek et al.

Part of iScience, 2024

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Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion

Pagnon de la Vega, María; Syvänen, Stina; Giedraitis, Vilmantas; Hooley, Monique et al.

Part of Acta neuropathologica communications, 2024

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A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro

Petersen, Inga; Morrison, Jamie I.; Petrovic, Alex; Babic, Neira et al.

Part of Scientific Reports, 2024

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Disease modifying effects of the amyloid-beta protofibril-selective antibody mAb158 in aged Tg2576 transgenic mice

Rizoska, Biljana; Zachrisson, Olof; Appelkvist, Paulina; Boström, Emma et al.

Part of Molecular and Cellular Neuroscience, 2024

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