Doctoral thesis and Research articles

Astrocytes in Alzheimer’s disease: Exploring the impact of amyloid-β pathology on neurotoxicity, metabolism and inflammation.

Beretta, Chiara

2024

Doctoral thesis, comprehensive summary

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A stargazer's guide to neurodegeneration: Astrocytes' role in the propagation of pathological proteins

Mothes, Tobias

2024

Doctoral thesis, comprehensive summary

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Harnessing the molecular Trojan horse: Evaluating properties of preclinical Aβ immunoPET radioligands for optimized brain delivery via the transferrin receptor

Bonvicini, Gillian

2023

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One-click away from higher contrast: Improvements to peripheral clearance for same-day immunoPET in Alzheimer’s disease

Schlein, Eva

2023

Doctoral thesis, comprehensive summary

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Visualising neurodegeneration in the living brain: Preclinical evaluation of PET radioligands

Xiong, Mengfei

2023

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Factors influencing transferrin receptor-mediated brain delivery: Evaluating preclinical antibody-based proteins for PET imaging in Alzheimer’s disease

Faresjö Melander, Rebecca

2023

Doctoral thesis, comprehensive summary

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Pathophysiological effects of alpha-synuclein on SNARE complex proteins in models of alpha-synucleinopathies

Brolin, Emma

2022

Doctoral thesis, comprehensive summary

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Ex‘PLA’ining the progression of pathological proteins in Alzheimer’s and Parkinson’s diseases: see(d)ing is believing

Behere, Anish

2022

Doctoral thesis, comprehensive summary

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CRISPR/Cas9-based therapies and the role of astrocytes in Alzheimer’s disease and Parkinson’s disease

Konstantinidis, Evangelos

2022

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Brain distribution of a bispecific antibody targeting Aβ

Tobias, Gustavsson

2022

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Characterization of the novel “Uppsala mutation” causing a familial form of early onset Alzheimer’s disease

Pagnon de la Vega, María

2021

Doctoral thesis, comprehensive summary

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Preclinical PET imaging and therapy of Alzheimer's disease

Meier, Silvio R.

2021

Doctoral thesis, comprehensive summary

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The role of glial cells in alpha-synuclein pathology: Focus on degradation, cell-to-cell propagation and inflammation

Rostami, Jinar

2020

Doctoral thesis, comprehensive summary

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Characterization of Physiological and Pathological Alpha-Synuclein: Implications for Parkinson’s Disease and Related Disorders

Almandoz Gil, Leire

2018

Doctoral thesis, comprehensive summary

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Cellular responses to amyloid-beta protofibrils: Focus on astrocytes, extracellular vesicles and antibody treatment

Nikitidou, Elisabeth

2018

Doctoral thesis, comprehensive summary

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Preclinical PET imaging of Alzheimer's disease progression

Fang, Xiaotian T.

2017

Doctoral thesis, comprehensive summary

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Alpha-Synuclein Oligomers: Cellular Mechanisms and Aspects of Antibody Treatment

Gustafsson, Gabriel

2017

Doctoral thesis, comprehensive summary

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Amyloid-β Protofibrils in Alzheimer´s Disease: Focus on Antibodies, Inflammation and Astrocytes

Söllvander, Sofia

2015

Doctoral thesis, comprehensive summary

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Therapeutic and functional studies in animal models of Alzheimer's disease

Gumucio, Astrid

2014

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Studies of α-synuclein Oligomers-with Relevance to Lewy Body Disorders

Fagerqvist, Therese

2013

Doctoral thesis, comprehensive summary

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Characterization of α-synuclein oligomers: Implications for Lewy Body Disorders

Näsström, Thomas

2011

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Heparan Sulfate in the Amyloidosis and Inflammation of Alzheimer’s Disease

O'Callaghan, Paul

2011

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Aβ Conformation Dependent Antibodies and Alzheimer's Disease

Sehlin, Dag

2010

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Modeling Amyloid-β Pathology in Alzheimer’s Disease Using the Arctic Mutation

Philipson, Ola

2010

Doctoral thesis, comprehensive summary

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Soluble amyloid-β aggregates in Alzheimer’s disease

Englund, Hillevi

2009

Doctoral thesis, comprehensive summary

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Targeting Early Stages of Alzheimer’s Disease in a Transgenic Model

Lord, Anna

2009

Doctoral thesis, comprehensive summary

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Molecular Mechanisms of Frontotemporal Lobar Degeneration

Skoglund, Lena

2009

Doctoral thesis, comprehensive summary

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Genetic Studies of Alzheimer's Disease

Blom, Elin

2008

Doctoral thesis, comprehensive summary

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Amyloid-β Protofibril Formation and Neurotoxicity: Implications for Alzheimer’s Disease

Johansson, Ann-Sofi

2007

Doctoral thesis, comprehensive summary

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Pathogenic Mechanisms of the Arctic Alzheimer Mutation

Sahlin, Charlotte

2007

Doctoral thesis, comprehensive summary

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Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery

Beretta, Chiara; Dakhel, Abdulkhalek; Eltom, Khalid; Rosqvist, Fredrik et al.

Part of Journal of Neuroinflammation, 2025

Article in journal

• DOI for Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery
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The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo

Bonvicini, Gillian; Singh, Sunitha; Sandersjoo, Lisa; Sehlin, Dag et al.

Part of Fluids and Barriers of the CNS, 2025

Article in journal

• DOI for The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo
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Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration

de la Rosa, Andrés; Metzendorf, Nicole G.; Efverström, Jonathan; Godec, Ana et al.

Part of Neurotherapeutics, 2025

Article in journal

• DOI for Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration
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Development of a toxin-selective immunotracer for in vivo detection of Clostridioides difficile infection by immunoPET

Gonzalez-Arjona, Mario; Cusso, Lorena; Alcala, Luis; Gonzalez, Maria Isabel et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2025

Article in journal

• DOI for Development of a toxin-selective immunotracer for in vivo detection of Clostridioides difficile infection by immunoPET
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DNA methylation patterns contribute to changes of cellular differentiation pathways in leukocytes with LOY from patients with Alzheimers disease

Jakalski, Marcin; Bruhn-Olszewska, Bożena; Rychlicka-Buniowska, Edyta; Davies, Hanna et al.

Part of Cellular and Molecular Life Sciences (CMLS), 2025

Article in journal

• DOI for DNA methylation patterns contribute to changes of cellular differentiation pathways in leukocytes with LOY from patients with Alzheimers disease
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Dual-ligand fluorescence microscopy enables chronological and spatial histological assignment of distinct amyloid-β deposits

Klingstedt, Therése; Shirani, Hamid; Parvin, Farjana; Nyström, Sofie et al.

Part of Journal of Biological Chemistry, 2025

Article in journal

• DOI for Dual-ligand fluorescence microscopy enables chronological and spatial histological assignment of distinct amyloid-β deposits
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Chemical imaging delineates Aβ plaque polymorphism across the Alzheimer’s disease spectrum

Koutarapu, Srinivas; Ge, Junyue; Dulewicz, Maciej; Srikrishna, Meera et al.

Part of Nature Communications, 2025

Article in journal

• DOI for Chemical imaging delineates Aβ plaque polymorphism across the Alzheimer’s disease spectrum
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Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues

Lee, Yea-Rin; Kaya, Ibrahim; Wik, Elin; Baijnath, Sooraj et al.

Part of Analytical Chemistry, p. 1338-1346, 2025

Article in journal

• DOI for Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues
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A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology

Sehlin, Dag; Roshanbin, Sahar; Zachrisson, Olof; Ingelsson, Martin et al.

Part of Neurotherapeutics, 2025

Article in journal

• DOI for A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology
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Molecular Therapeutics in Development to Treat Alzheimer's Disease

Tartaglia, Maria Carmela; Ingelsson, Martin

Part of Molecular Diagnosis & Therapy, p. 9-24, 2025

Article in journal

• DOI for Molecular Therapeutics in Development to Treat Alzheimer's Disease
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Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms

Beretta, Chiara; Svensson, Elina; Dakhel, Abdulkhalek; Zyśk, Marlena et al.

Part of Molecular and Cellular Neuroscience, 2024

Article in journal

• DOI for Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms
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Comparing in vitro affinity measurements of antibodies to TfR1: Surface plasmon resonance versus on-cell affinity

Bonvicini, Gillian; Singh, Sunitha; Nygren, Patrik; Xiong, Mengfei et al.

Part of Analytical Biochemistry, 2024

Article in journal

• DOI for Comparing in vitro affinity measurements of antibodies to TfR1: Surface plasmon resonance versus on-cell affinity
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Active CNS delivery of oxycodone in healthy and endotoxemic pigs

Bällgren, Frida; Bergfast, Tilda; Ginosyan, Aghavni; Mahajan, Jessica et al.

Part of Fluids and Barriers of the CNS, 2024

Article in journal

• DOI for Active CNS delivery of oxycodone in healthy and endotoxemic pigs
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Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment

Eltom, Khalid; Mothes, Tobias; Libard, Sylwia; Ingelsson, Martin et al.

Part of Acta neuropathologica communications, 2024

Article in journal

• DOI for Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment
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Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β

Faresjö, Rebecca; Sjöström, Elisabet O.; Dallas, Tiffany; Berglund, Magnus M. et al.

Part of mAbs, 2024

Article in journal

• DOI for Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β
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Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging

Gustavsson, Tobias; Herth, Matthias M.; Sehlin, Dag; Syvänen, Stina

Part of Upsala Journal of Medical Sciences, 2024

Article in journal

• DOI for Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging
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Accumulation of alpha-synuclein pathology in the liver exhibits post-translational modifications associated with Parkinson's disease

Hallbeck, Martin; Ekmark-Lewén, Sara; Kahle, Philipp J.; Ingelsson, Martin et al.

Part of iScience, 2024

Article in journal

• DOI for Accumulation of alpha-synuclein pathology in the liver exhibits post-translational modifications associated with Parkinson's disease
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Lecanemab demonstrates highly selective binding to Aβ protofibrils isolated from Alzheimer's disease brains

Johannesson, Malin; Soderberg, Linda; Zachrisson, Olof; Fritz, Nicolas et al.

Part of Molecular and Cellular Neuroscience, 2024

Article in journal

• DOI for Lecanemab demonstrates highly selective binding to Aβ protofibrils isolated from Alzheimer's disease brains
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Association of MGMT and BIN1 genes with Alzheimer's disease risk across sex and APOE ε4 status

Le Borgne, Julie; Amouyel, Philippe; Andreassen, Ole; Frikke-Schmidt, Ruth et al.

Part of Alzheimer's & Dementia, p. 2282-2284, 2024

Article in journal

• DOI for Association of MGMT and BIN1 genes with Alzheimer's disease risk across sex and APOE ε4 status
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X-chromosome-wide association study for Alzheimer's disease.

Le Borgne, Julie; Gomez, Lissette; Heikkinen, Sami; Amin, Najaf et al.

Part of Molecular Psychiatry, 2024

Article in journal

• DOI for X-chromosome-wide association study for Alzheimer's disease.

Spatial Neurolipidomics at the Single Amyloid-β Plaque Level in Postmortem Human Alzheimer's Disease Brain

Michno, Wojciech; Bowman, Andrew; Jha, Durga; Minta, Karolina et al.

Part of ACS Chemical Neuroscience, p. 877-888, 2024

Article in journal

• DOI for Spatial Neurolipidomics at the Single Amyloid-β Plaque Level in Postmortem Human Alzheimer's Disease Brain
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Tau processing and tau-mediated inflammation differ in human APOEε2 and APOEε4 astrocytes

Mothes, Tobias; Konstantinidis, Evangelos; Eltom, Khalid; Dakhel, Abdulkhalek et al.

Part of iScience, 2024

Article in journal

• DOI for Tau processing and tau-mediated inflammation differ in human APOEε2 and APOEε4 astrocytes
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Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion

Pagnon de la Vega, María; Syvänen, Stina; Giedraitis, Vilmantas; Hooley, Monique et al.

Part of Acta neuropathologica communications, 2024

Article in journal

• DOI for Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
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A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro

Petersen, Inga; Morrison, Jamie I.; Petrovic, Alex; Babic, Neira et al.

Part of Scientific Reports, 2024

Article in journal

• DOI for A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro
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Disease modifying effects of the amyloid-beta protofibril-selective antibody mAb158 in aged Tg2576 transgenic mice

Rizoska, Biljana; Zachrisson, Olof; Appelkvist, Paulina; Boström, Emma et al.

Part of Molecular and Cellular Neuroscience, 2024

Article in journal

• DOI for Disease modifying effects of the amyloid-beta protofibril-selective antibody mAb158 in aged Tg2576 transgenic mice
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Validation of a web-based self-administered test for cognitive assessment in a Swedish geriatric setting

Rystedt, Einar; Moren, Jakob; Lindbäck, Johan; Tedim Cruz, Vitor et al.

Part of PLOS ONE, 2024

Article in journal

• DOI for Validation of a web-based self-administered test for cognitive assessment in a Swedish geriatric setting
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Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody

Schlein, Eva; Andersson, Ken G.; Dallas, Tiffany; Syvänen, Stina et al.

Part of mAbs, 2024

Article in journal

• DOI for Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody
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Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET

Schlein, Eva; Rokka, Johanna; Odell, Luke R.; Lopes van den Broek, Sara et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2024

Article in journal

• DOI for Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET
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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Suzuki, Ken; Giedraitis, Vilmantas; Ingelsson, Martin; Lind, Lars et al.

Part of Nature, p. 347-357, 2024

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• DOI for Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
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Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities

Söderberg, Linda; Johannesson, Malin; Gkanatsiou, Eleni; Nygren, Patrik et al.

Part of Scientific Reports, 2024

Article in journal

• DOI for Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities
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Distinct Chemical Determinants are Essential for Achieving Ligands for Superior Optical Detection of Specific Amyloid-ß Deposits in Alzheimer's Disease

Wu, Xiongyu; Shirani, Hamid; Vidal, Ruben; Ghetti, Bernardino et al.

Part of ChemistryOpen, 2024

Article in journal

• DOI for Distinct Chemical Determinants are Essential for Achieving Ligands for Superior Optical Detection of Specific Amyloid-ß Deposits in Alzheimer's Disease
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Antibody engagement with amyloid‐beta does not inhibit [¹¹C]PiB binding for PET imaging

Xiong, Mengfei; Dahlén, Amelia; Roshanbin, Sahar; Wik, Elin et al.

Part of Journal of Neurochemistry, p. 2601-2610, 2024

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• DOI for Antibody engagement with amyloid‐beta does not inhibit [¹¹C]PiB binding for PET imaging
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"Prion-like" seeding and propagation of oligomeric protein assemblies in neurodegenerative disorders

Zampar, Silvia; Di Gregorio, Sonja E.; Grimmer, Gustavo; Watts, Joel C. et al.

Part of Frontiers in Neuroscience, 2024

Article, review/survey

• DOI for "Prion-like" seeding and propagation of oligomeric protein assemblies in neurodegenerative disorders

Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau

Banka, Vinay; Kelleher, Andrew; Sehlin, Dag; Hultqvist, Greta et al.

Part of Frontiers in Nuclear Medicine, 2023

Article in journal

• DOI for Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau
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Levels of inflammatory cytokines MCP-1, CCL4, and PD-L1 in CSF differentiate idiopathic normal pressure hydrocephalus from neurodegenerative diseases

Braun, Madelen; Boström, Gustaf; Ingelsson, Martin; Kilander, Lena et al.

Part of Fluids and Barriers of the CNS, 2023

Article in journal

• DOI for Levels of inflammatory cytokines MCP-1, CCL4, and PD-L1 in CSF differentiate idiopathic normal pressure hydrocephalus from neurodegenerative diseases
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Altered Distribution of SNARE Proteins in Primary Neurons Exposed to Different Alpha-Synuclein Proteoforms

Brolin, Emma; Ingelsson, Martin; Bergström, Joakim; Erlandsson, Anna

Part of Cellular and molecular neurobiology, p. 3023-3035, 2023

Article in journal

• DOI for Altered Distribution of SNARE Proteins in Primary Neurons Exposed to Different Alpha-Synuclein Proteoforms
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Phosphorylated α-synuclein in skin Schwann cells: a new biomarker for multiple system atrophy

Donadio, Vincenzo; Incensi, Alex; Rizzo, Giovanni; Westermark, Gunilla T. et al.

Part of Brain, p. 1065-1074, 2023

Article in journal

• DOI for Phosphorylated α-synuclein in skin Schwann cells: a new biomarker for multiple system atrophy

Reduction of brain stem pathology and transient amelioration of early cognitive symptoms in transgenic mice treated with a monoclonal antibody against α-synuclein oligomers/protofibrils

Ekmark-Lewén, Sara; Aniszewska, Agata; Molisak, Agnieszka; Gumucio, Astrid et al.

Part of AGING BRAIN, 2023

Article in journal

• DOI for Reduction of brain stem pathology and transient amelioration of early cognitive symptoms in transgenic mice treated with a monoclonal antibody against α-synuclein oligomers/protofibrils
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Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody

Faresjö, Rebecca; Sehlin, Dag; Syvänen, Stina

Part of Fluids and Barriers of the CNS, 2023

Article in journal

• DOI for Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody
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Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease

Gustavsson, Tobias; Metzendorf, Nicole G.; Wik, Elin; Roshanbin, Sahar et al.

Part of Alzheimer's Research & Therapy, 2023

Article in journal

• DOI for Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease
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The amyloid-beta pathway in Alzheimer's disease: a plain language summary

Hampel, Harald; Hu, Yan; Hardy, John; Blennow, Kaj et al.

Part of Neurodegenerative Disease Management, p. 141-149, 2023

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• DOI for The amyloid-beta pathway in Alzheimer's disease: a plain language summary
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Long-term effects of amyloid-beta deposits in human iPSC-derived astrocytes

Konstantinidis, Evangelos; Dakhel, Abdulkhalek; Beretta, Chiara; Erlandsson, Anna

Part of Molecular and Cellular Neuroscience, 2023

Article in journal

• DOI for Long-term effects of amyloid-beta deposits in human iPSC-derived astrocytes
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Intracellular deposits of amyloid-beta influence the ability of human iPSC-derived astrocytes to support neuronal function

Konstantinidis, Evangelos; Portal, Benjamin; Mothes, Tobias J.; Beretta, Chiara et al.

Part of Journal of Neuroinflammation, 2023

Article in journal

• DOI for Intracellular deposits of amyloid-beta influence the ability of human iPSC-derived astrocytes to support neuronal function
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The G51D SNCA mutation generates a slowly progressive alpha-synuclein strain in early-onset Parkinson's disease

Lau, Heather H. C.; Martinez-Valbuena, Ivan; So, Raphaella W. L.; Mehra, Surabhi et al.

Part of Acta neuropathologica communications, 2023

Article in journal

• DOI for The G51D SNCA mutation generates a slowly progressive alpha-synuclein strain in early-onset Parkinson's disease
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Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Le Guen, Yann; Luo, Guo; Ambati, Aditya; Damotte, Vincent et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2023

Article in journal

• DOI for Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
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Plasma Protein Profiling of Incident Cardiovascular Diseases: A Multisample Evaluation

Lind, Lars; Titova, Olga; Zeng, Rui; Zanetti, Daniela et al.

Part of CIRCULATION-GENOMIC AND PRECISION MEDICINE, 2023

Article in journal

• DOI for Plasma Protein Profiling of Incident Cardiovascular Diseases: A Multisample Evaluation
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Size matters: the impact of nucleus size on results from spatial transcriptomics

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Part of Journal of Translational Medicine, 2023

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Part of Acta neuropathologica communications, 2023

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van de Vegte, Yordi; Eppinga, Ruben P.; van der Ende, M. Yldau; Hagemeijer, Yanick et al.

Part of Nature Communications, 2023

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Wang, Ye; Bergström, Joakim; Ingelsson, Martin; Westermark, Gunilla

Part of Frontiers in Molecular Biosciences, 2023

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