Avhandlingar och publikationer
Avhandlingar
2024
Doktorsavhandling, sammanläggning
2024
Doktorsavhandling, sammanläggning
2023
Doktorsavhandling, sammanläggning
2023
Doktorsavhandling, sammanläggning
Visualising neurodegeneration in the living brain: Preclinical evaluation of PET radioligands
2023
Doktorsavhandling, sammanläggning
2023
Doktorsavhandling, sammanläggning
2022
Doktorsavhandling, sammanläggning
2022
Doktorsavhandling, sammanläggning
2022
Doktorsavhandling, sammanläggning
Brain distribution of a bispecific antibody targeting Aβ
2022
Doktorsavhandling, sammanläggning
2021
Doktorsavhandling, sammanläggning
Preclinical PET imaging and therapy of Alzheimer's disease
2021
Doktorsavhandling, sammanläggning
2020
Doktorsavhandling, sammanläggning
2018
Doktorsavhandling, sammanläggning
2018
Doktorsavhandling, sammanläggning
Preclinical PET imaging of Alzheimer's disease progression
2017
Doktorsavhandling, sammanläggning
Alpha-Synuclein Oligomers: Cellular Mechanisms and Aspects of Antibody Treatment
2017
Doktorsavhandling, sammanläggning
Amyloid-β Protofibrils in Alzheimer´s Disease: Focus on Antibodies, Inflammation and Astrocytes
2015
Doktorsavhandling, sammanläggning
Therapeutic and functional studies in animal models of Alzheimer's disease
2014
Doktorsavhandling, sammanläggning
Studies of α-synuclein Oligomers-with Relevance to Lewy Body Disorders
2013
Doktorsavhandling, sammanläggning
Characterization of α-synuclein oligomers: Implications for Lewy Body Disorders
2011
Doktorsavhandling, sammanläggning
Heparan Sulfate in the Amyloidosis and Inflammation of Alzheimer’s Disease
2011
Doktorsavhandling, sammanläggning
Aβ Conformation Dependent Antibodies and Alzheimer's Disease
2010
Doktorsavhandling, sammanläggning
Modeling Amyloid-β Pathology in Alzheimer’s Disease Using the Arctic Mutation
2010
Doktorsavhandling, sammanläggning
Soluble amyloid-β aggregates in Alzheimer’s disease
2009
Doktorsavhandling, sammanläggning
Targeting Early Stages of Alzheimer’s Disease in a Transgenic Model
2009
Doktorsavhandling, sammanläggning
Molecular Mechanisms of Frontotemporal Lobar Degeneration
2009
Doktorsavhandling, sammanläggning
Genetic Studies of Alzheimer's Disease
2008
Doktorsavhandling, sammanläggning
Amyloid-β Protofibril Formation and Neurotoxicity: Implications for Alzheimer’s Disease
2007
Doktorsavhandling, sammanläggning
Pathogenic Mechanisms of the Arctic Alzheimer Mutation
2007
Doktorsavhandling, sammanläggning
Vetenskapliga artiklar
Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery
Ingår i Journal of Neuroinflammation, 2025
Artikel i tidskrift
- DOI för Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery
- Ladda ner fulltext (pdf) av Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery
The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo
Ingår i Fluids and Barriers of the CNS, 2025
Artikel i tidskrift
- DOI för The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo
- Ladda ner fulltext (pdf) av The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo
Ingår i Neurotherapeutics, 2025
Artikel i tidskrift
- DOI för Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration
- Ladda ner fulltext (pdf) av Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration
Ingår i EJNMMI Radiopharmacy and Chemistry, 2025
Artikel i tidskrift
- DOI för Development of a toxin-selective immunotracer for in vivo detection of Clostridioides difficile infection by immunoPET
- Ladda ner fulltext (pdf) av Development of a toxin-selective immunotracer for in vivo detection of Clostridioides difficile infection by immunoPET
Ingår i Cellular and Molecular Life Sciences (CMLS), 2025
Artikel i tidskrift
- DOI för DNA methylation patterns contribute to changes of cellular differentiation pathways in leukocytes with LOY from patients with Alzheimers disease
- Ladda ner fulltext (pdf) av DNA methylation patterns contribute to changes of cellular differentiation pathways in leukocytes with LOY from patients with Alzheimers disease
Ingår i Journal of Biological Chemistry, 2025
Artikel i tidskrift
- DOI för Dual-ligand fluorescence microscopy enables chronological and spatial histological assignment of distinct amyloid-β deposits
- Ladda ner fulltext (pdf) av Dual-ligand fluorescence microscopy enables chronological and spatial histological assignment of distinct amyloid-β deposits
Chemical imaging delineates Aβ plaque polymorphism across the Alzheimer’s disease spectrum
Ingår i Nature Communications, 2025
Artikel i tidskrift
- DOI för Chemical imaging delineates Aβ plaque polymorphism across the Alzheimer’s disease spectrum
- Ladda ner fulltext (pdf) av Chemical imaging delineates Aβ plaque polymorphism across the Alzheimer’s disease spectrum
Ingår i Analytical Chemistry, s. 1338-1346, 2025
Artikel i tidskrift
- DOI för Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues
- Ladda ner fulltext (pdf) av Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues
Ingår i Neurotherapeutics, 2025
Artikel i tidskrift
- DOI för A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology
- Ladda ner fulltext (pdf) av A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology
Molecular Therapeutics in Development to Treat Alzheimer's Disease
Ingår i Molecular Diagnosis & Therapy, s. 9-24, 2025
Artikel i tidskrift
- DOI för Molecular Therapeutics in Development to Treat Alzheimer's Disease
- Ladda ner fulltext (pdf) av Molecular Therapeutics in Development to Treat Alzheimer's Disease
Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms
Ingår i Molecular and Cellular Neuroscience, 2024
Artikel i tidskrift
- DOI för Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms
- Ladda ner fulltext (pdf) av Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms
Ingår i Analytical Biochemistry, 2024
Artikel i tidskrift
- DOI för Comparing in vitro affinity measurements of antibodies to TfR1: Surface plasmon resonance versus on-cell affinity
- Ladda ner fulltext (pdf) av Comparing in vitro affinity measurements of antibodies to TfR1: Surface plasmon resonance versus on-cell affinity
Active CNS delivery of oxycodone in healthy and endotoxemic pigs
Ingår i Fluids and Barriers of the CNS, 2024
Artikel i tidskrift
- DOI för Active CNS delivery of oxycodone in healthy and endotoxemic pigs
- Ladda ner fulltext (pdf) av Active CNS delivery of oxycodone in healthy and endotoxemic pigs
Ingår i Acta neuropathologica communications, 2024
Artikel i tidskrift
- DOI för Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment
- Ladda ner fulltext (pdf) av Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment
Ingår i mAbs, 2024
Artikel i tidskrift
- DOI för Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β
- Ladda ner fulltext (pdf) av Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β
Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging
Ingår i Upsala Journal of Medical Sciences, 2024
Artikel i tidskrift
- DOI för Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging
- Ladda ner fulltext (pdf) av Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging
Ingår i iScience, 2024
Artikel i tidskrift
- DOI för Accumulation of alpha-synuclein pathology in the liver exhibits post-translational modifications associated with Parkinson's disease
- Ladda ner fulltext (pdf) av Accumulation of alpha-synuclein pathology in the liver exhibits post-translational modifications associated with Parkinson's disease
Ingår i Molecular and Cellular Neuroscience, 2024
Artikel i tidskrift
- DOI för Lecanemab demonstrates highly selective binding to Aβ protofibrils isolated from Alzheimer's disease brains
- Ladda ner fulltext (pdf) av Lecanemab demonstrates highly selective binding to Aβ protofibrils isolated from Alzheimer's disease brains
Association of MGMT and BIN1 genes with Alzheimer's disease risk across sex and APOE ε4 status
Ingår i Alzheimer's & Dementia, s. 2282-2284, 2024
Artikel i tidskrift
- DOI för Association of MGMT and BIN1 genes with Alzheimer's disease risk across sex and APOE ε4 status
- Ladda ner fulltext (pdf) av Association of MGMT and BIN1 genes with Alzheimer's disease risk across sex and APOE ε4 status
X-chromosome-wide association study for Alzheimer's disease.
Ingår i Molecular Psychiatry, 2024
Artikel i tidskrift
Ingår i ACS Chemical Neuroscience, s. 877-888, 2024
Artikel i tidskrift
- DOI för Spatial Neurolipidomics at the Single Amyloid-β Plaque Level in Postmortem Human Alzheimer's Disease Brain
- Ladda ner fulltext (pdf) av Spatial Neurolipidomics at the Single Amyloid-β Plaque Level in Postmortem Human Alzheimer's Disease Brain
Tau processing and tau-mediated inflammation differ in human APOEε2 and APOEε4 astrocytes
Ingår i iScience, 2024
Artikel i tidskrift
- DOI för Tau processing and tau-mediated inflammation differ in human APOEε2 and APOEε4 astrocytes
- Ladda ner fulltext (pdf) av Tau processing and tau-mediated inflammation differ in human APOEε2 and APOEε4 astrocytes
Ingår i Acta neuropathologica communications, 2024
Artikel i tidskrift
- DOI för Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
- Ladda ner fulltext (pdf) av Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
Ingår i Scientific Reports, 2024
Artikel i tidskrift
- DOI för A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro
- Ladda ner fulltext (pdf) av A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro
Ingår i Molecular and Cellular Neuroscience, 2024
Artikel i tidskrift
- DOI för Disease modifying effects of the amyloid-beta protofibril-selective antibody mAb158 in aged Tg2576 transgenic mice
- Ladda ner fulltext (pdf) av Disease modifying effects of the amyloid-beta protofibril-selective antibody mAb158 in aged Tg2576 transgenic mice
Ingår i PLOS ONE, 2024
Artikel i tidskrift
- DOI för Validation of a web-based self-administered test for cognitive assessment in a Swedish geriatric setting
- Ladda ner fulltext (pdf) av Validation of a web-based self-administered test for cognitive assessment in a Swedish geriatric setting
Ingår i mAbs, 2024
Artikel i tidskrift
- DOI för Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody
- Ladda ner fulltext (pdf) av Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody
Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET
Ingår i EJNMMI Radiopharmacy and Chemistry, 2024
Artikel i tidskrift
- DOI för Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET
- Ladda ner fulltext (pdf) av Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
Ingår i Nature, s. 347-357, 2024
Artikel i tidskrift
- DOI för Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
- Ladda ner fulltext (pdf) av Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
Ingår i Scientific Reports, 2024
Artikel i tidskrift
- DOI för Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities
- Ladda ner fulltext (pdf) av Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities
Ingår i ChemistryOpen, 2024
Artikel i tidskrift
- DOI för Distinct Chemical Determinants are Essential for Achieving Ligands for Superior Optical Detection of Specific Amyloid-ß Deposits in Alzheimer's Disease
- Ladda ner fulltext (pdf) av Distinct Chemical Determinants are Essential for Achieving Ligands for Superior Optical Detection of Specific Amyloid-ß Deposits in Alzheimer's Disease
Antibody engagement with amyloid‐beta does not inhibit [11C]PiB binding for PET imaging
Ingår i Journal of Neurochemistry, s. 2601-2610, 2024
Artikel i tidskrift
- DOI för Antibody engagement with amyloid‐beta does not inhibit [11C]PiB binding for PET imaging
- Ladda ner fulltext (pdf) av Antibody engagement with amyloid‐beta does not inhibit [11C]PiB binding for PET imaging
"Prion-like" seeding and propagation of oligomeric protein assemblies in neurodegenerative disorders
Ingår i Frontiers in Neuroscience, 2024
Artikel, forskningsöversikt
Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau
Ingår i Frontiers in Nuclear Medicine, 2023
Artikel i tidskrift
- DOI för Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau
- Ladda ner fulltext (pdf) av Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau
Ingår i Fluids and Barriers of the CNS, 2023
Artikel i tidskrift
- DOI för Levels of inflammatory cytokines MCP-1, CCL4, and PD-L1 in CSF differentiate idiopathic normal pressure hydrocephalus from neurodegenerative diseases
- Ladda ner fulltext (pdf) av Levels of inflammatory cytokines MCP-1, CCL4, and PD-L1 in CSF differentiate idiopathic normal pressure hydrocephalus from neurodegenerative diseases
Ingår i Cellular and molecular neurobiology, s. 3023-3035, 2023
Artikel i tidskrift
- DOI för Altered Distribution of SNARE Proteins in Primary Neurons Exposed to Different Alpha-Synuclein Proteoforms
- Ladda ner fulltext (pdf) av Altered Distribution of SNARE Proteins in Primary Neurons Exposed to Different Alpha-Synuclein Proteoforms
Phosphorylated α-synuclein in skin Schwann cells: a new biomarker for multiple system atrophy
Ingår i Brain, s. 1065-1074, 2023
Artikel i tidskrift
Ingår i AGING BRAIN, 2023
Artikel i tidskrift
- DOI för Reduction of brain stem pathology and transient amelioration of early cognitive symptoms in transgenic mice treated with a monoclonal antibody against α-synuclein oligomers/protofibrils
- Ladda ner fulltext (pdf) av Reduction of brain stem pathology and transient amelioration of early cognitive symptoms in transgenic mice treated with a monoclonal antibody against α-synuclein oligomers/protofibrils
Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody
Ingår i Fluids and Barriers of the CNS, 2023
Artikel i tidskrift
- DOI för Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody
- Ladda ner fulltext (pdf) av Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody
Ingår i Alzheimer's Research & Therapy, 2023
Artikel i tidskrift
- DOI för Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease
- Ladda ner fulltext (pdf) av Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease
The amyloid-beta pathway in Alzheimer's disease: a plain language summary
Ingår i Neurodegenerative Disease Management, s. 141-149, 2023
Artikel i tidskrift
- DOI för The amyloid-beta pathway in Alzheimer's disease: a plain language summary
- Ladda ner fulltext (pdf) av The amyloid-beta pathway in Alzheimer's disease: a plain language summary
Long-term effects of amyloid-beta deposits in human iPSC-derived astrocytes
Ingår i Molecular and Cellular Neuroscience, 2023
Artikel i tidskrift
- DOI för Long-term effects of amyloid-beta deposits in human iPSC-derived astrocytes
- Ladda ner fulltext (pdf) av Long-term effects of amyloid-beta deposits in human iPSC-derived astrocytes
Ingår i Journal of Neuroinflammation, 2023
Artikel i tidskrift
- DOI för Intracellular deposits of amyloid-beta influence the ability of human iPSC-derived astrocytes to support neuronal function
- Ladda ner fulltext (pdf) av Intracellular deposits of amyloid-beta influence the ability of human iPSC-derived astrocytes to support neuronal function
Ingår i Acta neuropathologica communications, 2023
Artikel i tidskrift
- DOI för The G51D SNCA mutation generates a slowly progressive alpha-synuclein strain in early-onset Parkinson's disease
- Ladda ner fulltext (pdf) av The G51D SNCA mutation generates a slowly progressive alpha-synuclein strain in early-onset Parkinson's disease
Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2023
Artikel i tidskrift
- DOI för Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
- Ladda ner fulltext (pdf) av Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
Plasma Protein Profiling of Incident Cardiovascular Diseases: A Multisample Evaluation
Ingår i CIRCULATION-GENOMIC AND PRECISION MEDICINE, 2023
Artikel i tidskrift
- DOI för Plasma Protein Profiling of Incident Cardiovascular Diseases: A Multisample Evaluation
- Ladda ner fulltext (pdf) av Plasma Protein Profiling of Incident Cardiovascular Diseases: A Multisample Evaluation
Size matters: the impact of nucleus size on results from spatial transcriptomics
Ingår i Journal of Translational Medicine, 2023
Artikel i tidskrift
- DOI för Size matters: the impact of nucleus size on results from spatial transcriptomics
- Ladda ner fulltext (pdf) av Size matters: the impact of nucleus size on results from spatial transcriptomics
Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology
Ingår i Acta neuropathologica communications, 2023
Artikel i tidskrift
- DOI för Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology
- Ladda ner fulltext (pdf) av Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology
Genetic insights into resting heart rate and its role in cardiovascular disease
Ingår i Nature Communications, 2023
Artikel i tidskrift
- DOI för Genetic insights into resting heart rate and its role in cardiovascular disease
- Ladda ner fulltext (pdf) av Genetic insights into resting heart rate and its role in cardiovascular disease
Studies on alpha-synuclein and islet amyloid polypeptide interaction
Ingår i Frontiers in Molecular Biosciences, 2023
Artikel i tidskrift
- DOI för Studies on alpha-synuclein and islet amyloid polypeptide interaction
- Ladda ner fulltext (pdf) av Studies on alpha-synuclein and islet amyloid polypeptide interaction