Avhandlingar och publikationer
Avhandlingar
2024
Doktorsavhandling, sammanläggning
2024
Doktorsavhandling, sammanläggning
2023
Doktorsavhandling, sammanläggning
2023
Doktorsavhandling, sammanläggning
Visualising neurodegeneration in the living brain: Preclinical evaluation of PET radioligands
2023
Doktorsavhandling, sammanläggning
2023
Doktorsavhandling, sammanläggning
2022
Doktorsavhandling, sammanläggning
2022
Doktorsavhandling, sammanläggning
2022
Doktorsavhandling, sammanläggning
Brain distribution of a bispecific antibody targeting Aβ
2022
Doktorsavhandling, sammanläggning
2021
Doktorsavhandling, sammanläggning
Preclinical PET imaging and therapy of Alzheimer's disease
2021
Doktorsavhandling, sammanläggning
2020
Doktorsavhandling, sammanläggning
2018
Doktorsavhandling, sammanläggning
2018
Doktorsavhandling, sammanläggning
Preclinical PET imaging of Alzheimer's disease progression
2017
Doktorsavhandling, sammanläggning
Alpha-Synuclein Oligomers: Cellular Mechanisms and Aspects of Antibody Treatment
2017
Doktorsavhandling, sammanläggning
Amyloid-β Protofibrils in Alzheimer´s Disease: Focus on Antibodies, Inflammation and Astrocytes
2015
Doktorsavhandling, sammanläggning
Therapeutic and functional studies in animal models of Alzheimer's disease
2014
Doktorsavhandling, sammanläggning
Studies of α-synuclein Oligomers-with Relevance to Lewy Body Disorders
2013
Doktorsavhandling, sammanläggning
Characterization of α-synuclein oligomers: Implications for Lewy Body Disorders
2011
Doktorsavhandling, sammanläggning
Heparan Sulfate in the Amyloidosis and Inflammation of Alzheimer’s Disease
2011
Doktorsavhandling, sammanläggning
Aβ Conformation Dependent Antibodies and Alzheimer's Disease
2010
Doktorsavhandling, sammanläggning
Modeling Amyloid-β Pathology in Alzheimer’s Disease Using the Arctic Mutation
2010
Doktorsavhandling, sammanläggning
Soluble amyloid-β aggregates in Alzheimer’s disease
2009
Doktorsavhandling, sammanläggning
Targeting Early Stages of Alzheimer’s Disease in a Transgenic Model
2009
Doktorsavhandling, sammanläggning
Molecular Mechanisms of Frontotemporal Lobar Degeneration
2009
Doktorsavhandling, sammanläggning
Genetic Studies of Alzheimer's Disease
2008
Doktorsavhandling, sammanläggning
Amyloid-β Protofibril Formation and Neurotoxicity: Implications for Alzheimer’s Disease
2007
Doktorsavhandling, sammanläggning
Pathogenic Mechanisms of the Arctic Alzheimer Mutation
2007
Doktorsavhandling, sammanläggning
Vetenskapliga artiklar
Ingår i Neuroscience, s. 22-36, 2026
Artikel i tidskrift
Ingår i Experimental Neurology, 2026
Artikel i tidskrift
- DOI för Evaluating the impact of age and treatment on neuroinflammation-related proteins in mouse models of proteinopathies
- Ladda ner fulltext (pdf) av Evaluating the impact of age and treatment on neuroinflammation-related proteins in mouse models of proteinopathies
Zombosomes are anucleated cell couriers that spread α-synuclein pathology
Ingår i Cell Reports, 2026
Artikel i tidskrift
- DOI för Zombosomes are anucleated cell couriers that spread α-synuclein pathology
- Ladda ner fulltext (pdf) av Zombosomes are anucleated cell couriers that spread α-synuclein pathology
Ingår i Molecular Neurodegeneration, 2026
Artikel, forskningsöversikt
- DOI för Diagnostic biomarkers for α-synucleinopathies- state of the art and future developments: a systematic review
- Ladda ner fulltext (pdf) av Diagnostic biomarkers for α-synucleinopathies- state of the art and future developments: a systematic review
Ingår i Fluids and Barriers of the CNS, 2026
Artikel i tidskrift
- DOI för Targeted CSF metabolomics and conformal prediction improve diagnostic accuracy of normal pressure hydrocephalus
- Ladda ner fulltext (pdf) av Targeted CSF metabolomics and conformal prediction improve diagnostic accuracy of normal pressure hydrocephalus
Ingår i Acta neuropathologica communications, 2026
Artikel i tidskrift
- DOI för MALDI mass spectrometry imaging (MSI) reveals molecular and structural heterogeneity of amyloid-β in sporadic Alzheimer's disease and Down syndrome
- Ladda ner fulltext (pdf) av MALDI mass spectrometry imaging (MSI) reveals molecular and structural heterogeneity of amyloid-β in sporadic Alzheimer's disease and Down syndrome
α-Synuclein purification significantly impacts seed amplification assay performance and consistency
Ingår i Acta neuropathologica communications, 2025
Artikel i tidskrift
- DOI för α-Synuclein purification significantly impacts seed amplification assay performance and consistency
- Ladda ner fulltext (pdf) av α-Synuclein purification significantly impacts seed amplification assay performance and consistency
Ingår i Nature Aging, s. 366-375, 2025
Artikel i tidskrift
- DOI för Soluble cerebral Aβ protofibrils link Aβ plaque pathology to changes in CSF Aβ42/Aβ40 ratios, neurofilament light and tau in Alzheimer’s disease model micece
- Ladda ner fulltext (pdf) av Soluble cerebral Aβ protofibrils link Aβ plaque pathology to changes in CSF Aβ42/Aβ40 ratios, neurofilament light and tau in Alzheimer’s disease model micece
Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery
Ingår i Journal of Neuroinflammation, 2025
Artikel i tidskrift
- DOI för Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery
- Ladda ner fulltext (pdf) av Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery
Ingår i Fluids and Barriers of the CNS, 2025
Artikel i tidskrift
- DOI för High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose
- Ladda ner fulltext (pdf) av High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose
The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo
Ingår i Fluids and Barriers of the CNS, 2025
Artikel i tidskrift
- DOI för The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo
- Ladda ner fulltext (pdf) av The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo
Machine learning in Alzheimer's disease genetics
Ingår i Nature Communications, 2025
Artikel i tidskrift
- DOI för Machine learning in Alzheimer's disease genetics
- Ladda ner fulltext (pdf) av Machine learning in Alzheimer's disease genetics
PET imaging of TREM2 in amyloid-beta induced neuroinflammation
Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 4320-4333, 2025
Artikel i tidskrift
- DOI för PET imaging of TREM2 in amyloid-beta induced neuroinflammation
- Ladda ner fulltext (pdf) av PET imaging of TREM2 in amyloid-beta induced neuroinflammation
Ingår i Neurotherapeutics, 2025
Artikel i tidskrift
- DOI för Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration
- Ladda ner fulltext (pdf) av Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration
Ingår i EJNMMI Radiopharmacy and Chemistry, 2025
Artikel i tidskrift
- DOI för Development of a toxin-selective immunotracer for in vivo detection of Clostridioides difficile infection by immunoPET
- Ladda ner fulltext (pdf) av Development of a toxin-selective immunotracer for in vivo detection of Clostridioides difficile infection by immunoPET
Ingår i STAR Protocols, 2025
Artikel i tidskrift
- DOI för Protocol for immunodetection of α-synuclein pathology in paraffin-embedded liver tissues from murine models of Parkinson's disease
- Ladda ner fulltext (pdf) av Protocol for immunodetection of α-synuclein pathology in paraffin-embedded liver tissues from murine models of Parkinson's disease
Ingår i Journal of Alzheimer's Disease, s. 1778-1789, 2025
Artikel i tidskrift
- DOI för Plasma p-tau 217 correlates strongly with cerebrospinal fluid Aβ 42 and increases over a ten-year period in amyloid-positive, non-demented very old men
- Ladda ner fulltext (pdf) av Plasma p-tau 217 correlates strongly with cerebrospinal fluid Aβ 42 and increases over a ten-year period in amyloid-positive, non-demented very old men
Ingår i Cellular and Molecular Life Sciences (CMLS), 2025
Artikel i tidskrift
- DOI för DNA methylation patterns contribute to changes of cellular differentiation pathways in leukocytes with LOY from patients with Alzheimers disease
- Ladda ner fulltext (pdf) av DNA methylation patterns contribute to changes of cellular differentiation pathways in leukocytes with LOY from patients with Alzheimers disease
Ingår i Journal of Biological Chemistry, 2025
Artikel i tidskrift
- DOI för Dual-ligand fluorescence microscopy enables chronological and spatial histological assignment of distinct amyloid-β deposits
- Ladda ner fulltext (pdf) av Dual-ligand fluorescence microscopy enables chronological and spatial histological assignment of distinct amyloid-β deposits
Chemical imaging delineates Aβ plaque polymorphism across the Alzheimer’s disease spectrum
Ingår i Nature Communications, 2025
Artikel i tidskrift
- DOI för Chemical imaging delineates Aβ plaque polymorphism across the Alzheimer’s disease spectrum
- Ladda ner fulltext (pdf) av Chemical imaging delineates Aβ plaque polymorphism across the Alzheimer’s disease spectrum
X-chromosome-wide association study for Alzheimer's disease
Ingår i Molecular Psychiatry, s. 2335-2346, 2025
Artikel i tidskrift
- DOI för X-chromosome-wide association study for Alzheimer's disease
- Ladda ner fulltext (pdf) av X-chromosome-wide association study for Alzheimer's disease
Ingår i Analytical Chemistry, s. 1338-1346, 2025
Artikel i tidskrift
- DOI för Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues
- Ladda ner fulltext (pdf) av Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues
Ingår i Translational Neurodegeneration, 2025
Artikel i tidskrift
- DOI för Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine
- Ladda ner fulltext (pdf) av Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine
4R-tau seeding activity reveals molecular subtypes in progressive supranuclear palsy
Ingår i Nature Communications, 2025
Artikel i tidskrift
- DOI för 4R-tau seeding activity reveals molecular subtypes in progressive supranuclear palsy
- Ladda ner fulltext (pdf) av 4R-tau seeding activity reveals molecular subtypes in progressive supranuclear palsy
Ingår i Biomedicine and Pharmacotherapy, 2025
Artikel i tidskrift
- DOI för Somatostatin therapy, neprilysin activation, and amyloid beta reduction: A novel approach for Alzheimer's treatment
- Ladda ner fulltext (pdf) av Somatostatin therapy, neprilysin activation, and amyloid beta reduction: A novel approach for Alzheimer's treatment
Ingår i Frontiers in Neuroscience, 2025
Artikel i tidskrift
- DOI för Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates
- Ladda ner fulltext (pdf) av Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates
Ingår i Nature Genetics, 2025
Artikel i tidskrift
- DOI för Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations
- Ladda ner fulltext (pdf) av Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations
Loss of Y chromosome in Alzheimer's patients co-occurs with somatic mutations beyond CHIP drivers
Ingår i Life Science Alliance, 2025
Artikel i tidskrift
- DOI för Loss of Y chromosome in Alzheimer's patients co-occurs with somatic mutations beyond CHIP drivers
- Ladda ner fulltext (pdf) av Loss of Y chromosome in Alzheimer's patients co-occurs with somatic mutations beyond CHIP drivers
Fluorine-18 ImmunoPET Imaging of Antibody Brain Kinetics and Amyloid-Beta Pathology
Ingår i ACS Pharmacology & Translational Science, s. 2804-2813, 2025
Artikel i tidskrift
- DOI för Fluorine-18 ImmunoPET Imaging of Antibody Brain Kinetics and Amyloid-Beta Pathology
- Ladda ner fulltext (pdf) av Fluorine-18 ImmunoPET Imaging of Antibody Brain Kinetics and Amyloid-Beta Pathology
Ingår i EJNMMI Radiopharmacy and Chemistry, 2025
Artikel i tidskrift
- DOI för Brain-penetrating peptide and antibody radioligands for proof-of-concept PET imaging of fibrin in Alzheimer's disease
- Ladda ner fulltext (pdf) av Brain-penetrating peptide and antibody radioligands for proof-of-concept PET imaging of fibrin in Alzheimer's disease
Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease
Ingår i The Journal of Prevention of Alzheimer's Disease, 2025
Artikel i tidskrift
- DOI för Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease
- Ladda ner fulltext (pdf) av Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease
Ingår i Neurotherapeutics, 2025
Artikel i tidskrift
- DOI för A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology
- Ladda ner fulltext (pdf) av A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology
Molecular Therapeutics in Development to Treat Alzheimer's Disease
Ingår i Molecular Diagnosis & Therapy, s. 9-24, 2025
Artikel i tidskrift
- DOI för Molecular Therapeutics in Development to Treat Alzheimer's Disease
- Ladda ner fulltext (pdf) av Molecular Therapeutics in Development to Treat Alzheimer's Disease
Distinct inflammatory profiles in young-onset versus late-onset Alzheimer's disease
Ingår i Alzheimer's & Dementia, 2025
Artikel i tidskrift
- DOI för Distinct inflammatory profiles in young-onset versus late-onset Alzheimer's disease
- Ladda ner fulltext (pdf) av Distinct inflammatory profiles in young-onset versus late-onset Alzheimer's disease
Ingår i Acta neuropathologica communications, 2025
Artikel i tidskrift
- DOI för Cryo-EM studies of amyloid-β fibrils from human and murine brains carrying the Uppsala APP mutation (Δ690-695)
- Ladda ner fulltext (pdf) av Cryo-EM studies of amyloid-β fibrils from human and murine brains carrying the Uppsala APP mutation (Δ690-695)
Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms
Ingår i Molecular and Cellular Neuroscience, 2024
Artikel i tidskrift
- DOI för Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms
- Ladda ner fulltext (pdf) av Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms
Ingår i Analytical Biochemistry, 2024
Artikel i tidskrift
- DOI för Comparing in vitro affinity measurements of antibodies to TfR1: Surface plasmon resonance versus on-cell affinity
- Ladda ner fulltext (pdf) av Comparing in vitro affinity measurements of antibodies to TfR1: Surface plasmon resonance versus on-cell affinity
Active CNS delivery of oxycodone in healthy and endotoxemic pigs
Ingår i Fluids and Barriers of the CNS, 2024
Artikel i tidskrift
- DOI för Active CNS delivery of oxycodone in healthy and endotoxemic pigs
- Ladda ner fulltext (pdf) av Active CNS delivery of oxycodone in healthy and endotoxemic pigs
Ingår i Acta neuropathologica communications, 2024
Artikel i tidskrift
- DOI för Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment
- Ladda ner fulltext (pdf) av Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment
Ingår i mAbs, 2024
Artikel i tidskrift
- DOI för Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β
- Ladda ner fulltext (pdf) av Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β
Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging
Ingår i Upsala Journal of Medical Sciences, 2024
Artikel i tidskrift
- DOI för Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging
- Ladda ner fulltext (pdf) av Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging
Ingår i iScience, 2024
Artikel i tidskrift
- DOI för Accumulation of alpha-synuclein pathology in the liver exhibits post-translational modifications associated with Parkinson's disease
- Ladda ner fulltext (pdf) av Accumulation of alpha-synuclein pathology in the liver exhibits post-translational modifications associated with Parkinson's disease
Ingår i Molecular and Cellular Neuroscience, 2024
Artikel i tidskrift
- DOI för Lecanemab demonstrates highly selective binding to Aβ protofibrils isolated from Alzheimer's disease brains
- Ladda ner fulltext (pdf) av Lecanemab demonstrates highly selective binding to Aβ protofibrils isolated from Alzheimer's disease brains
Association of MGMT and BIN1 genes with Alzheimer's disease risk across sex and APOE ε4 status
Ingår i Alzheimer's & Dementia, s. 2282-2284, 2024
Artikel i tidskrift
- DOI för Association of MGMT and BIN1 genes with Alzheimer's disease risk across sex and APOE ε4 status
- Ladda ner fulltext (pdf) av Association of MGMT and BIN1 genes with Alzheimer's disease risk across sex and APOE ε4 status
Ingår i ACS Chemical Neuroscience, s. 877-888, 2024
Artikel i tidskrift
- DOI för Spatial Neurolipidomics at the Single Amyloid-β Plaque Level in Postmortem Human Alzheimer's Disease Brain
- Ladda ner fulltext (pdf) av Spatial Neurolipidomics at the Single Amyloid-β Plaque Level in Postmortem Human Alzheimer's Disease Brain
Tau processing and tau-mediated inflammation differ in human APOEε2 and APOEε4 astrocytes
Ingår i iScience, 2024
Artikel i tidskrift
- DOI för Tau processing and tau-mediated inflammation differ in human APOEε2 and APOEε4 astrocytes
- Ladda ner fulltext (pdf) av Tau processing and tau-mediated inflammation differ in human APOEε2 and APOEε4 astrocytes
Ingår i Acta neuropathologica communications, 2024
Artikel i tidskrift
- DOI för Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
- Ladda ner fulltext (pdf) av Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
Ingår i Scientific Reports, 2024
Artikel i tidskrift
- DOI för A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro
- Ladda ner fulltext (pdf) av A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro
Ingår i Molecular and Cellular Neuroscience, 2024
Artikel i tidskrift
- DOI för Disease modifying effects of the amyloid-beta protofibril-selective antibody mAb158 in aged Tg2576 transgenic mice
- Ladda ner fulltext (pdf) av Disease modifying effects of the amyloid-beta protofibril-selective antibody mAb158 in aged Tg2576 transgenic mice
Ingår i PLOS ONE, 2024
Artikel i tidskrift
- DOI för Validation of a web-based self-administered test for cognitive assessment in a Swedish geriatric setting
- Ladda ner fulltext (pdf) av Validation of a web-based self-administered test for cognitive assessment in a Swedish geriatric setting