Dylan Valli

Mechanistic and Structural Insights into IAPP Fibril Polymorphism: From Self-Assembly to Structure-Based Design of Therapeutics via Cryo-EM

Valli, Dylan

2026

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A Highly Sensitive Water-Soluble Donor-Acceptor Dye for Early-Stage Amyloid Aggregation Kinetics

Scattolini, Giorgio; Torres-Méndez, Carlos Enrique; Valli, Dylan; Kuska, Mikolaj Ignacy et al.

Ingår i Journal of Physical Chemistry B, s. 3042-3053, 2026

• DOI för A Highly Sensitive Water-Soluble Donor-Acceptor Dye for Early-Stage Amyloid Aggregation Kinetics
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High-resolution structure of proIAPP(1–48) fibrils suggests a mechanistic pathway for diabetes-associated IAPP fibril polymorphs

Valli, Dylan; Maj, Michał

Ingår i RSC Chemical Biology, s. 38-43, 2026

• DOI för High-resolution structure of proIAPP(1–48) fibrils suggests a mechanistic pathway for diabetes-associated IAPP fibril polymorphs
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Cryo-EM exposes diverse polymorphism in IAPP mutants to guide the rational design of peptide-based therapeutics

Ooi, Saik Ann; Valli, Dylan; Kuska, Mikolaj I.; Mari, Helena et al.

Ingår i Journal of Molecular Biology, 2025

• DOI för Cryo-EM exposes diverse polymorphism in IAPP mutants to guide the rational design of peptide-based therapeutics
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Cryo-Electron Microscopy Provides Mechanistic Insights into Solution-Dependent Polymorphism and Cross-Aggregation Phenomena of the Human and Rat Islet Amyloid Polypeptides

Valli, Dylan; Ooi, Saik Ann; Kaya, Ibrahim; Thomassen, Asger Berg et al.

Ingår i Biochemistry, s. 2583-2595, 2025

• DOI för Cryo-Electron Microscopy Provides Mechanistic Insights into Solution-Dependent Polymorphism and Cross-Aggregation Phenomena of the Human and Rat Islet Amyloid Polypeptides
• Ladda ner fulltext (pdf) av Cryo-Electron Microscopy Provides Mechanistic Insights into Solution-Dependent Polymorphism and Cross-Aggregation Phenomena of the Human and Rat Islet Amyloid Polypeptides

A Highly Sensitive Water-Soluble Donor-Acceptor Dye for Early-Stage Amyloid Aggregation Kinetics

Scattolini, Giorgio; Torres-Méndez, Carlos Enrique; Valli, Dylan; Kuska, Mikolaj Ignacy et al.

Ingår i Journal of Physical Chemistry B, s. 3042-3053, 2026

• DOI för A Highly Sensitive Water-Soluble Donor-Acceptor Dye for Early-Stage Amyloid Aggregation Kinetics
• Ladda ner fulltext (pdf) av A Highly Sensitive Water-Soluble Donor-Acceptor Dye for Early-Stage Amyloid Aggregation Kinetics

High-resolution structure of proIAPP(1–48) fibrils suggests a mechanistic pathway for diabetes-associated IAPP fibril polymorphs

Valli, Dylan; Maj, Michał

Ingår i RSC Chemical Biology, s. 38-43, 2026

• DOI för High-resolution structure of proIAPP(1–48) fibrils suggests a mechanistic pathway for diabetes-associated IAPP fibril polymorphs
• Ladda ner fulltext (pdf) av High-resolution structure of proIAPP(1–48) fibrils suggests a mechanistic pathway for diabetes-associated IAPP fibril polymorphs

Cryo-EM exposes diverse polymorphism in IAPP mutants to guide the rational design of peptide-based therapeutics

Ooi, Saik Ann; Valli, Dylan; Kuska, Mikolaj I.; Mari, Helena et al.

Ingår i Journal of Molecular Biology, 2025

• DOI för Cryo-EM exposes diverse polymorphism in IAPP mutants to guide the rational design of peptide-based therapeutics
• Ladda ner fulltext (pdf) av Cryo-EM exposes diverse polymorphism in IAPP mutants to guide the rational design of peptide-based therapeutics

Cryo-Electron Microscopy Provides Mechanistic Insights into Solution-Dependent Polymorphism and Cross-Aggregation Phenomena of the Human and Rat Islet Amyloid Polypeptides

Valli, Dylan; Ooi, Saik Ann; Kaya, Ibrahim; Thomassen, Asger Berg et al.

Ingår i Biochemistry, s. 2583-2595, 2025

• DOI för Cryo-Electron Microscopy Provides Mechanistic Insights into Solution-Dependent Polymorphism and Cross-Aggregation Phenomena of the Human and Rat Islet Amyloid Polypeptides
• Ladda ner fulltext (pdf) av Cryo-Electron Microscopy Provides Mechanistic Insights into Solution-Dependent Polymorphism and Cross-Aggregation Phenomena of the Human and Rat Islet Amyloid Polypeptides

Improving cryo-EM grids for amyloid fibrils using interface-active solutions and spectator proteins

Valli, Dylan; Ooi, Saik Ann; Scattolini, Giorgio; Chaudhary, Himanshu et al.

Ingår i Biophysical Journal, s. 718-729, 2024

• DOI för Improving cryo-EM grids for amyloid fibrils using interface-active solutions and spectator proteins
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Yeast as a tool for membrane protein production and structure determination

Carlesso, Antonio; Delgado, Raquel; Isant, Oriol Ruiz; Uwangue, Owens et al.

Ingår i FEMS yeast research (Print), 2022

• DOI för Yeast as a tool for membrane protein production and structure determination
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Mechanistic and Structural Insights into IAPP Fibril Polymorphism: From Self-Assembly to Structure-Based Design of Therapeutics via Cryo-EM

Valli, Dylan

2026

• Ladda ner fulltext 1 (pdf) av Mechanistic and Structural Insights into IAPP Fibril Polymorphism: From Self-Assembly to Structure-Based Design of Therapeutics via Cryo-EM
• Ladda ner fulltext 2 (pdf) av Mechanistic and Structural Insights into IAPP Fibril Polymorphism: From Self-Assembly to Structure-Based Design of Therapeutics via Cryo-EM

Direct solid-phase peptide synthesis on electrode surfaces: an alternative approach to post-synthesis heterogenization

Spallacci, Claudia; Valli, Dylan; D'Amario, Luca; Maj, Michal et al.