Vilmantas Giedraitis
Forskare vid Institutionen för folkhälso- och vårdvetenskap; Klinisk geriatrik
- Telefon:
- 018-471 50 38
- Mobiltelefon:
- 073-469 74 55
- E-post:
- vilmantas.giedraitis@uu.se
- Besöksadress:
- Husargatan 3, BMC
751 22 Uppsala - Postadress:
- Husargatan 3, BMC, Box 564
751 22 UPPSALA
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Publikationer
Urval av publikationer
- Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease (2016)
- eta-Secretase processing of APP inhibits neuronal activity in the hippocampus (2015)
- Acute sleep deprivation increases serum levels of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in healthy young men (2014)
- Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer (2014)
- Age-related accumulation of somatic structural changes in the nuclear genome of human blood cells in vivo (2012)
- Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype (2009)
- Plasma β Amyloid and the Risk of Alzheimer Disease and Dementia in Elderly Men (2008)
- The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer's disease (2007)
- New Alzheimer's disease locus on chromosome 8 (2006)
Senaste publikationer
- Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion (2024)
- Genetic drivers of heterogeneity in type 2 diabetes pathophysiology (2024)
- Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes (2023)
- Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease (2023)
- Step length during Timed Up and Go performance – preliminary results of a cross-sectional cohort study. (2023)
Alla publikationer
Artiklar
- Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion (2024)
- Genetic drivers of heterogeneity in type 2 diabetes pathophysiology (2024)
- Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes (2023)
- Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease (2023)
- Dual-Task Interference of Gait Parameters During Different Conditions of the Timed Up-and-Go Test Performed by Community-Dwelling Older Adults (2023)
- Prediction of conversion to dementia disorders based on timed up and go dual-task test verbal and motor outcomes (2023)
- New insights into the genetic etiology of Alzheimer's disease and related dementias (2022)
- Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies (2022)
- CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease PSEN1 M146L mutation (2022)
- Mixed Pathologies in a Subject with a Novel PSEN1 G206R Mutation (2022)
- Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation (2022)
- Mutation analysis of disease causing genes in patients with early onset or familial forms of Alzheimer’s disease and frontotemporal dementia (2022)
- Different Inflammatory Signatures in Alzheimer's Disease and Frontotemporal Dementia Cerebrospinal Fluid (2021)
- The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid beta fibril formation (2021)
- Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores (2021)
- Immune cells lacking Y chromosome show dysregulation of autosomal gene expression (2021)
- Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability (2021)
- The genomics of heart failure (2021)
- Extraction of gait parameters from marker-free video recordings of Timed Up-and-Go tests (2021)
- Timed “Up & Go” Dual-Task Tests (2021)
- Timed Up-and-Go Dual-Task Testing in the Assessment of Cognitive Function (2020)
- Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals (2020)
- The association between plasma proteomics and incident cardiovascular disease identifies MMP-12 as a promising cardiovascular risk marker in patients with chronic kidney disease (2020)
- Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals (2020)
- Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction (2020)
- Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure (2020)
- Dual-task tests predict conversion to dementia (2020)
- Dual-task tests discriminate between dementia, mild cognitive impairment, subjective cognitive impairment, and healthy controls - a cross-sectional cohort study. (2020)
- Improved Differential Diagnosis of Alzheimer's Disease by Integrating ELISA and Mass Spectrometry-Based Cerebrospinal Fluid Biomarkers (2019)
- Mosaic loss of chromosome Y in leukocytes matters (2019)
- Cardiovascular Risk Factors Associated With Venous Thromboembolism (2019)
- Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution (2019)
- Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019)
- Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies (2019)
- The metabolites urobilin and sphingomyelin (30:1) are associated with incident heart failure in the general population (2019)
- Rationale for a Swedish cohort consortium (2019)
- Risk factors for subarachnoid haemorrhage (2019)
- Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria (2019)
- Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels (2019)
- A catalog of genetic loci associated with kidney function from analyses of a million individuals (2019)
- Dual-Task Performance and Neurodegeneration (2019)
- Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. (2018)
- CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease (2018)
- Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders (2018)
- Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps (2018)
- Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes (2018)
- Multiplex proteomics for prediction of major cardiovascular events in type 2 diabetes (2018)
- Glucose challenge metabolomics implicates medium-chain acylcarnitines in insulin resistance (2018)
- Circulating proteins as predictors of incident heart failure in the elderly (2018)
- Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2018)
- Stability of Proteins in Dried Blood Spot Biobanks. (2017)
- Data Descriptor (2017)
- Rare and low-frequency coding variants alter human adult height (2017)
- Genetic loci associated with heart rate variability and their effects on cardiac disease risk (2017)
- Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease (2017)
- Cognitive function in very old men does not correlate to biomarkers of Alzheimer's disease (2017)
- Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney (2017)
- Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk (2017)
- Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease (2016)
- Non-targeted metabolomics combined with genetic analyses identifies bile acid synthesis and phospholipid metabolism as being associated with incident type 2 diabetes (2016)
- The genetic architecture of type 2 diabetes (2016)
- No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis (2016)
- Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity (2016)
- Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels (2016)
- Protein Biomarkers for Insulin Resistance and Type 2 Diabetes Risk in Two Large Community Cohorts (2016)
- Cystatin C and Cardiovascular Disease (2016)
- Self-reported sleep disturbance is associated with Alzheimer's disease risk in men (2015)
- Mutagenesis (2015)
- Age- and sex-specific causal effects of adiposity on cardiovascular risk factors (2015)
- Adiposity as a cause of cardiovascular disease (2015)
- Genetic studies of body mass index yield new insights for obesity biology (2015)
- New genetic loci link adipose and insulin biology to body fat distribution (2015)
- eta-Secretase processing of APP inhibits neuronal activity in the hippocampus (2015)
- Acute sleep deprivation increases serum levels of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in healthy young men (2014)
- Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer (2014)
- Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independently of obesity (2014)
- Defining the role of common variation in the genomic and biological architecture of adult human height (2014)
- Rare Variants in Calcium Homeostasis Modulator 1 (CALHM1) Found in Early Onset Alzheimer's Disease Patients Alter Calcium Homeostasis (2013)
- Age-related accumulation of somatic structural changes in the nuclear genome of human blood cells in vivo (2012)
- Age-related somatic structural changes in the nuclear genome of human blood cells (2012)
- CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid (2010)
- The CALHM1 P86L Polymorphism is a Genetic Modifier of Age at Onset in Alzheimer's Disease (2010)
- Neurofilament ELISA validation (2010)
- Cystatin C Levels are Positively Correlated with both Aβ42 and Tau Levels in Cerebrospinal Fluid in Persons with Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Controls (2010)
- Higher Cathepsin B Levels in Plasma in Alzheimer's Disease Compared to Healthy Controls (2010)
- Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype (2009)
- Further analysis of previously implicated linkage regions for Alzheimer’s disease in affected relative pairs (2009)
- Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men (2009)
- Frontotemporal dementia in a large Swedish family is caused by a progranulin null mutation (2009)
- No evidence of PGRN or MAPT gene dosage alterations in a collection of patients with frontotemporal lobar degeneration (2009)
- Plasma β Amyloid and the Risk of Alzheimer Disease and Dementia in Elderly Men (2008)
- Serum cystatin C and the risk of Alzheimer disease in elderly men (2008)
- The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer's disease (2007)
- Association study of cholesterol-related genes in Alzheimer's disease (2007)
- New Alzheimer's disease locus on chromosome 8 (2006)
- Adult-onset autosomal dominant leukodystrophy with autonomic symptoms restricted to 1.5 Mbp on chromosome 5q23 (2006)
- CRISPR/Cas9 as a tool to disrupt wild-type and A53T SNCA in sporadic and familial Parkinson’s disease
- Metabolite profiles during an oral glucose tolerance test reveal new associations with clamp-measured insulin sensitivity
- The Uppsala APP mutation promotes wildtype Aβ aggregation and deposition in vivo
- The Uppsala APP deletion causes early onset autosomal dominant Alzheimer’s disease by altering APP processing and increasing amyloid-β fibril formation
- Transgenic mice harboring the Uppsala APP mutation display altered APP processing and accelerated Aβ42 pathology with distinct structural features
Konferenser
