Vilmantas Giedraitis

Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease

Dumanski, Jan P.; Lambert, Jean-Charles; Rasi, Chiara; Giedraitis, Vilmantas et al.

Ingår i American Journal of Human Genetics, s. 1208-1219, 2016

• DOI för Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease
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eta-Secretase processing of APP inhibits neuronal activity in the hippocampus

Willem, Michael; Tahirovic, Sabina; Busche, Marc Aurel; Ovsepian, Saak V. et al.

Ingår i Nature, s. 443-447, 2015

• DOI för eta-Secretase processing of APP inhibits neuronal activity in the hippocampus

Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer

Forsberg, Lars A.; Rasi, Chiara; Malmqvist, Niklas; Davies, Hanna et al.

Ingår i Nature Genetics, s. 624-628, 2014

• DOI för Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer

Acute sleep deprivation increases serum levels of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in healthy young men

Benedict, Christian; Cedernaes, Jonathan; Giedraitis, Vilmantas; Nilsson, Emil K et al.

Ingår i Sleep, s. 195-198, 2014

• DOI för Acute sleep deprivation increases serum levels of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in healthy young men

Age-related accumulation of somatic structural changes in the nuclear genome of human blood cells in vivo

Dumanski, Jan P.; Forsberg, L. A.; Rasi, C.; Razzaghian, H. R. et al.

Ingår i Journal of Medical Genetics, 2012

Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype

Blom, Elin S.; Giedraitis, Vilmantas; Zetterberg, Henrik; Fukumoto, Hiroaki et al.

Ingår i Dementia and Geriatric Cognitive Disorders, s. 458-464, 2009

• DOI för Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype

Plasma β Amyloid and the Risk of Alzheimer Disease and Dementia in Elderly Men: A Prospective, Population-Based Cohort Study

Sundelöf, Johan; Giedraitis, Vilmantas; Irizarry, Michael C; Sundström, Johan et al.

Ingår i Archives of Neurology, s. 256-63, 2008

• DOI för Plasma β Amyloid and the Risk of Alzheimer Disease and Dementia in Elderly Men: A Prospective, Population-Based Cohort Study

The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer's disease

Giedraitis, Vilmantas; Sundelöf, Johan; Irizarry, Michael C; Gårevik, Nina et al.

Ingår i Neuroscience Letters, s. 127-131, 2007

• DOI för The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer's disease

New Alzheimer's disease locus on chromosome 8

Giedraitis, Vilmantas; Hedlund, M.; Skoglund, Lena; Blom, Elin et al.

Ingår i Journal of Medical Genetics, s. 931-935, 2006

• DOI för New Alzheimer's disease locus on chromosome 8

GWAS meta-analysis of cerebrospinal fluid Alzheimer's biomarkers reveals loci regulating lipids, brain volume and autophagy

Timsina, Jigyasha; Jiang, Chenyang; McCartney, Daniel L.; Tao, Feifei et al.

Ingår i Nature Communications, 2026

• DOI för GWAS meta-analysis of cerebrospinal fluid Alzheimer's biomarkers reveals loci regulating lipids, brain volume and autophagy
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Development of a model for care coordination for the assessment and follow-up of risk for cognitive impairment: A study protocol

Åberg, Anna Cristina; Lindblom, Sebastian; Littbrand, Håkan; Lood, Qarin et al.

Ingår i International Journal of Integrated Care, s. 490-490, 2026

• DOI för Development of a model for care coordination for the assessment and follow-up of risk for cognitive impairment: A study protocol

First genome-wide association study reveals immune-mediated aetiopathology in idiopathic achalasia

Grover, Sandeep; Gockel, Ines; Latiano, Anna; Mokrowiecka, Anna et al.

Ingår i Gut, s. 476-485, 2026

• DOI för First genome-wide association study reveals immune-mediated aetiopathology in idiopathic achalasia
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Characterization of a distinct form of vimentin in the neurodegenerative brain

Dakhel, Abdulkhalek; Vestin, Johanna; Giedraitis, Vilmantas; Nyholm, Dag et al.

Ingår i Acta neuropathologica communications, 2026

• DOI för Characterization of a distinct form of vimentin in the neurodegenerative brain
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A multicentre validation study of the Swedish version of the Normalization Process Theory Measure S-NoMAD

Åberg, Anna Cristina; Wallin, Lars; Tistad, Malin; Weineland, Sandra et al.

Ingår i Implementation Science Communications, 2026

• DOI för A multicentre validation study of the Swedish version of the Normalization Process Theory Measure S-NoMAD
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GWAS meta-analysis of cerebrospinal fluid Alzheimer's biomarkers reveals loci regulating lipids, brain volume and autophagy

Timsina, Jigyasha; Jiang, Chenyang; McCartney, Daniel L.; Tao, Feifei et al.

Ingår i Nature Communications, 2026

• DOI för GWAS meta-analysis of cerebrospinal fluid Alzheimer's biomarkers reveals loci regulating lipids, brain volume and autophagy
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Development of a model for care coordination for the assessment and follow-up of risk for cognitive impairment: A study protocol

Åberg, Anna Cristina; Lindblom, Sebastian; Littbrand, Håkan; Lood, Qarin et al.

Ingår i International Journal of Integrated Care, s. 490-490, 2026

• DOI för Development of a model for care coordination for the assessment and follow-up of risk for cognitive impairment: A study protocol

First genome-wide association study reveals immune-mediated aetiopathology in idiopathic achalasia

Grover, Sandeep; Gockel, Ines; Latiano, Anna; Mokrowiecka, Anna et al.

Ingår i Gut, s. 476-485, 2026

• DOI för First genome-wide association study reveals immune-mediated aetiopathology in idiopathic achalasia
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Characterization of a distinct form of vimentin in the neurodegenerative brain

Dakhel, Abdulkhalek; Vestin, Johanna; Giedraitis, Vilmantas; Nyholm, Dag et al.

Ingår i Acta neuropathologica communications, 2026

• DOI för Characterization of a distinct form of vimentin in the neurodegenerative brain
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A multicentre validation study of the Swedish version of the Normalization Process Theory Measure S-NoMAD

Åberg, Anna Cristina; Wallin, Lars; Tistad, Malin; Weineland, Sandra et al.

Ingår i Implementation Science Communications, 2026

• DOI för A multicentre validation study of the Swedish version of the Normalization Process Theory Measure S-NoMAD
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The Timed Up and Go dual-task test's cognitive and motor outcomes show promising test-retest reliability in older adults with perceived memory impairment

Löfgren, Niklas; Giedraitis, Vilmantas; Halvorsen, Kjartan; Rosendahl, Erik et al.

Ingår i Frontiers in Aging, 2026

• DOI för The Timed Up and Go dual-task test's cognitive and motor outcomes show promising test-retest reliability in older adults with perceived memory impairment
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Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes

Henry, Albert; Mo, Xiaodong; Finan, Chris; Chaffin, Mark D. et al.

Ingår i Nature Genetics, s. 815-828, 2025

• DOI för Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes
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X-chromosome-wide association study for Alzheimer's disease

Le Borgne, Julie; Gomez, Lissette; Heikkinen, Sami; Amin, Najaf et al.

Ingår i Molecular Psychiatry, s. 2335-2346, 2025

• DOI för X-chromosome-wide association study for Alzheimer's disease
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Plasma p-tau ₂₁₇ correlates strongly with cerebrospinal fluid Aβ ₄₂ and increases over a ten-year period in amyloid-positive, non-demented very old men

Hellquist, Elisabeth; Janelidze, Shorena; Weidung, Bodil; Franzon, Kristin et al.

Ingår i Journal of Alzheimer's Disease, s. 1778-1789, 2025

• DOI för Plasma p-tau ₂₁₇ correlates strongly with cerebrospinal fluid Aβ ₄₂ and increases over a ten-year period in amyloid-positive, non-demented very old men
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Machine learning in Alzheimer's disease genetics

Bracher-Smith, Matthew; Melograna, Federico; Ulm, Brittany; Bellenguez, Celine et al.

Ingår i Nature Communications, 2025

• DOI för Machine learning in Alzheimer's disease genetics
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Prediabetes transitions to normoglycaemia or type 2 diabetes and associated risk factors in the Obesity, Diabetes and Cardiovascular Disease Collaboration: an individual-level pooled analysis of 19 prospective cohort studies

Davoodian, Najmeh; Lotfaliany, Mojtaba; Huxley, Rachel R.; Lee, Crystal Man Ying et al.

Ingår i The Lancet Global Health, s. 1533-1542, 2025

• DOI för Prediabetes transitions to normoglycaemia or type 2 diabetes and associated risk factors in the Obesity, Diabetes and Cardiovascular Disease Collaboration: an individual-level pooled analysis of 19 prospective cohort studies
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Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations

Nicolas, Aude; Sherva, Richard; Grenier-Boley, Benjamin; Kim, Yoontae et al.

Ingår i Nature Genetics, 2025

• DOI för Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations
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The interplay of genetics and fatty acid metabolism: exploring their impact on metabolic syndrome in Swedish men

Oskarsdottir, Harpa; Palsson, Arnar; Olafsdottir, Erla B.; Giedraitis, Vilmantas et al.

Ingår i Nutrition Journal, 2025

• DOI för The interplay of genetics and fatty acid metabolism: exploring their impact on metabolic syndrome in Swedish men
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Extracted step parameters during the timed up and go test discriminate between groups with different levels of cognitive ability: a cross-sectional study

Löfgren, Niklas; Berglund, Lars; Giedraitis, Vilmantas; Halvorsen, Kjartan et al.

Ingår i BMC Geriatrics, 2025

• DOI för Extracted step parameters during the timed up and go test discriminate between groups with different levels of cognitive ability: a cross-sectional study
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DNA methylation patterns contribute to changes of cellular differentiation pathways in leukocytes with LOY from patients with Alzheimers disease

Jakalski, Marcin; Bruhn-Olszewska, Bożena; Rychlicka-Buniowska, Edyta; Davies, Hanna et al.

Ingår i Cellular and Molecular Life Sciences (CMLS), 2025

• DOI för DNA methylation patterns contribute to changes of cellular differentiation pathways in leukocytes with LOY from patients with Alzheimers disease
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Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy

Zheng, Sean L; Henry, Albert; Cannie, Douglas; Lee, Michael et al.

Ingår i Nature Genetics, s. 2646-2658, 2024

• DOI för Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy
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Prognostic Value of Cardiovascular Biomarkers in the Population

Neumann, Johannes Tobias; Twerenbold, Raphael; Weimann, Jessica; Ballantyne, Christie M. et al.

Ingår i Journal of the American Medical Association (JAMA), s. 1898-1909, 2024

• DOI för Prognostic Value of Cardiovascular Biomarkers in the Population

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Suzuki, Ken; Giedraitis, Vilmantas; Ingelsson, Martin; Lind, Lars et al.

Ingår i Nature, s. 347-357, 2024

• DOI för Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
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Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits

Keaton, Jacob M; Kamali, Zoha; Xie, Tian; Vaez, Ahmad et al.

Ingår i Nature Genetics, s. 778-791, 2024

• DOI för Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits
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Characteristics of and Risk Factors for Depressive Symptoms Preceding Dementia: A Study of 82-Year-Old Men From the Uppsala Longitudinal Study of Adult Men

Kallström, Angelica; Giedraitis, Vilmantas; Franzon, Kristin; Löwenmark, Malin et al.

Ingår i International Journal of Geriatric Psychiatry, 2024

• DOI för Characteristics of and Risk Factors for Depressive Symptoms Preceding Dementia: A Study of 82-Year-Old Men From the Uppsala Longitudinal Study of Adult Men
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Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion

Pagnon de la Vega, María; Syvänen, Stina; Giedraitis, Vilmantas; Hooley, Monique et al.

Ingår i Acta neuropathologica communications, 2024

• DOI för Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
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Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease

Luo, Jiao; Thomassen, Jesper Qvist; Bellenguez, Celine; Grenier-Boley, Benjamin et al.

Ingår i JAMA Network Open, 2023

• DOI för Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease
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Prediction of conversion to dementia disorders based on timed up and go dual-task test verbal and motor outcomes: a five-year prospective memory-clinic-based study

Åberg, Anna Cristina; Petersson, Johanna R.; Giedraitis, Vilmantas; Mckee, Kevin J. et al.

Ingår i BMC Geriatrics, 2023

• DOI för Prediction of conversion to dementia disorders based on timed up and go dual-task test verbal and motor outcomes: a five-year prospective memory-clinic-based study
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Dual-Task Interference of Gait Parameters During Different Conditions of the Timed Up-and-Go Test Performed by Community-Dwelling Older Adults

Åberg, Anna Cristina; Larsson, Liss Elin; Giedraitis, Vilmantas; Berglund, Lars et al.

Ingår i Journal of Aging and Physical Activity, s. 823-832, 2023

• DOI för Dual-Task Interference of Gait Parameters During Different Conditions of the Timed Up-and-Go Test Performed by Community-Dwelling Older Adults
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Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Le Guen, Yann; Luo, Guo; Ambati, Aditya; Damotte, Vincent et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2023

• DOI för Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
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Mutation analysis of disease causing genes in patients with early onset or familial forms of Alzheimer’s disease and frontotemporal dementia

Pagnon de la Vega, María; Näslund, Carl; Brundin, RoseMarie; Lannfelt, Lars et al.

Ingår i BMC Genomics, 2022

• DOI för Mutation analysis of disease causing genes in patients with early onset or familial forms of Alzheimer’s disease and frontotemporal dementia
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Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies

Gorski, Mathias; Rasheed, Humaira; Teumer, Alexander; Thomas, Laurent F. et al.

Ingår i Kidney International, s. 624-639, 2022

• DOI för Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies
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New insights into the genetic etiology of Alzheimer's disease and related dementias

Bellenguez, Celine; Giedraitis, Vilmantas; Ingelsson, Martin; Lambert, Jean-Charles

Ingår i Nature Genetics, s. 412-436, 2022

• DOI för New insights into the genetic etiology of Alzheimer's disease and related dementias
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Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Mahajan, Anubha; Spracklen, Cassandra N.; Zhang, Weihua; Ng, Maggie C. Y. et al.

Ingår i Nature Genetics, s. 560-572, 2022

• DOI för Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Mixed Pathologies in a Subject with a Novel PSEN1 G206R Mutation

Libard, Sylwia; Giedraitis, Vilmantas; Kilander, Lena; Ingelsson, Martin et al.

Ingår i Journal of Alzheimer's Disease, s. 1601-1614, 2022

• DOI för Mixed Pathologies in a Subject with a Novel PSEN1 G206R Mutation
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CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease PSEN1 M146L mutation

Konstantinidis, Evangelos; Molisak, Agnieszka; Perrin, Florian; Streubel-Gallasch, Linn et al.

Ingår i Molecular Therapy Nucleic Acids, s. 450-461, 2022

• DOI för CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease PSEN1 M146L mutation
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The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid beta fibril formation

de la Vega, Maria Pagnon; Giedraitis, Vilmantas; Michno, Wojciech; Kilander, Lena et al.

Ingår i Science Translational Medicine, 2021

• DOI för The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid beta fibril formation

Extraction of gait parameters from marker-free video recordings of Timed Up-and-Go tests: Validity, inter- and intra-rater reliability

Åberg, Anna Cristina; Olsson, Fredrik; Åhman, Hanna Bozkurt; Tarassova, Olga et al.

Ingår i Gait & Posture, s. 489-495, 2021

• DOI för Extraction of gait parameters from marker-free video recordings of Timed Up-and-Go tests: Validity, inter- and intra-rater reliability
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Timed “Up & Go” Dual-Task Tests: Age- and Sex-Specific Reference Values and Test-Retest Reliability in Cognitively Healthy Controls

Åhman, Hanna Bozkurt; Berglund, Lars; Cedervall, Ylva; Giedraitis, Vilmantas et al.

Ingår i Physical Therapy, 2021

• DOI för Timed “Up & Go” Dual-Task Tests: Age- and Sex-Specific Reference Values and Test-Retest Reliability in Cognitively Healthy Controls
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Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Lagou, Vasiliki; Maegi, Reedik; Hottenga, Jouke- Jan; Grallert, Harald et al.

Ingår i Nature Communications, 2021

• DOI för Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
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Immune cells lacking Y chromosome show dysregulation of autosomal gene expression

Dumanski, Jan P.; Halvardson, Jonatan; Davies, Hanna; Rychlicka-Buniowska, Edyta et al.

Ingår i Cellular and Molecular Life Sciences (CMLS), s. 4019-4033, 2021

• DOI för Immune cells lacking Y chromosome show dysregulation of autosomal gene expression
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The genomics of heart failure: design and rationale of the HERMES consortium

Lumbers, R. Thomas; Shah, Sonia; Lin, Honghuang; Czuba, Tomasz et al.

Ingår i ESC Heart Failure, s. 5531-5541, 2021

• DOI för The genomics of heart failure: design and rationale of the HERMES consortium
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Different Inflammatory Signatures in Alzheimer's Disease and Frontotemporal Dementia Cerebrospinal Fluid

Boström, Gustaf; Freyhult, Eva; Virhammar, Johan; Alcolea, Daniel et al.

Ingår i Journal of Alzheimer's Disease, s. 629-640, 2021

• DOI för Different Inflammatory Signatures in Alzheimer's Disease and Frontotemporal Dementia Cerebrospinal Fluid
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Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

de Rojas, Itziar; Moreno-Grau, Sonia; Tesi, Niccolo; Grenier-Boley, Benjamin et al.

Ingår i Nature Communications, 2021

• DOI för Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
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The association between plasma proteomics and incident cardiovascular disease identifies MMP-12 as a promising cardiovascular risk marker in patients with chronic kidney disease

Feldreich, Tobias; Nowak, Christoph; Carlsson, Axel C.; ostgren, Carl-Johan et al.

Ingår i Atherosclerosis, s. 11-15, 2020

• DOI för The association between plasma proteomics and incident cardiovascular disease identifies MMP-12 as a promising cardiovascular risk marker in patients with chronic kidney disease
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Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

Ntalla, Ioanna; Weng, Lu-Chen; Cartwright, James H.; Hall, Amelia Weber et al.

Ingår i Nature Communications, 2020

• DOI för Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
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Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Shah, Sonia; Henry, Albert; Roselli, Carolina; Lin, Honghuang et al.

Ingår i Nature Communications, 2020

• DOI för Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
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Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

Folkersen, Lasse; Gustafsson, Stefan; Wang, Qin; Hvidberg Hansen, Daniel et al.

Ingår i Nature Metabolism, s. 1135-1148, 2020

• DOI för Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals

Danielsson, Marcus; Halvardson, Jonatan; Davies, Hanna; Moghadam, Behrooz Torabi et al.

Ingår i European Journal of Human Genetics, s. 349-357, 2020

• DOI för Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals
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Dual-task tests discriminate between dementia, mild cognitive impairment, subjective cognitive impairment, and healthy controls - a cross-sectional cohort study.

Åhman, Hanna Bozkurt; Cedervall, Ylva; Kilander, Lena; Giedraitis, Vilmantas et al.

Ingår i BMC Geriatrics, 2020

• DOI för Dual-task tests discriminate between dementia, mild cognitive impairment, subjective cognitive impairment, and healthy controls - a cross-sectional cohort study.
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Timed Up-and-Go Dual-Task Testing in the Assessment of Cognitive Function: A Mixed Methods Observational Study for Development of the UDDGait Protocol

Cedervall, Ylva; Stenberg, Anna M.; Åhman, Hanna Bozkurt; Giedraitis, Vilmantas et al.

Ingår i International Journal of Environmental Research and Public Health, 2020

• DOI för Timed Up-and-Go Dual-Task Testing in the Assessment of Cognitive Function: A Mixed Methods Observational Study for Development of the UDDGait Protocol
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Dual-task tests predict conversion to dementia: A prospective memory-clinic-based cohort study

Åhman, Hanna Bozkurt; Berglund, Lars; Cedervall, Ylva; Kilander, Lena et al.

Ingår i International Journal of Environmental Research and Public Health, 2020

• DOI för Dual-task tests predict conversion to dementia: A prospective memory-clinic-based cohort study
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A catalog of genetic loci associated with kidney function from analyses of a million individuals

Wuttke, Matthias; Li, Yong; Li, Man; Sieber, Karsten B. et al.

Ingår i Nature Genetics, s. 957-972, 2019

• DOI för A catalog of genetic loci associated with kidney function from analyses of a million individuals

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Kunkle, Brian W.; Giedraitis, Vilmantas; Kilander, Lena; Brundin, RoseMarie et al.

Ingår i Nature Genetics, s. 414-430, 2019

• DOI för Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

Teumer, Alexander; Li, Yong; Ghasemi, Sahar; Prins, Bram P. et al.

Ingår i Nature Communications, 2019

• DOI för Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria
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The metabolites urobilin and sphingomyelin (30:1) are associated with incident heart failure in the general population

Stenemo, Markus; Ganna, Andrea; Salihovic, Samira; Nowak, Christoph et al.

Ingår i ESC Heart Failure, s. 764-773, 2019

• DOI för The metabolites urobilin and sphingomyelin (30:1) are associated with incident heart failure in the general population
• Ladda ner fulltext (pdf) av The metabolites urobilin and sphingomyelin (30:1) are associated with incident heart failure in the general population

Mosaic loss of chromosome Y in leukocytes matters

Forsberg, Lars A.; Halvardson, Jonatan; Rychlicka-Buniowska, Edyta; Danielsson, Marcus et al.

Ingår i Nature Genetics, s. 4-7, 2019

• DOI för Mosaic loss of chromosome Y in leukocytes matters

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

Tin, Adrienne; Marten, Jonathan; Kuhns, Victoria L. Halperin; Li, Yong et al.

Ingår i Nature Genetics, s. 1459-1474, 2019

• DOI för Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

Cardiovascular Risk Factors Associated With Venous Thromboembolism

Gregson, John; Kaptoge, Stephen; Bolton, Thomas; Pennells, Lisa et al.

Ingår i JAMA cardiology, s. 163-173, 2019

• DOI för Cardiovascular Risk Factors Associated With Venous Thromboembolism

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

Justice, Anne E.; Giedraitis, Vilmantas; Gustafsson, Stefan; Ingelsson, Erik et al.

Ingår i Nature Genetics, s. 452-469, 2019

• DOI för Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

Risk factors for subarachnoid haemorrhage: a nationwide cohort of 950 000 adults

Sundström, Johan; Söderholm, Martin; Söderberg, Stefan; Alfredsson, Lars et al.

Ingår i International Journal of Epidemiology, s. 2018-2025, 2019

• DOI för Risk factors for subarachnoid haemorrhage: a nationwide cohort of 950 000 adults

Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies

Morris, Andrew P; Le, Thu H; Wu, Haojia; Akbarov, Artur et al.

Ingår i Nature Communications, 2019

• DOI för Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies
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Dual-Task Performance and Neurodegeneration: Correlations Between Timed Up-and-Go Dual-Task Test Outcomes and Alzheimer's Disease Cerebrospinal Fluid Biomarkers

Åhman, Hanna Bozkurt; Giedraitis, Vilmantas; Cedervall, Ylva; Lennhed, Bjorn et al.

Ingår i Journal of Alzheimer's Disease, 2019

• DOI för Dual-Task Performance and Neurodegeneration: Correlations Between Timed Up-and-Go Dual-Task Test Outcomes and Alzheimer's Disease Cerebrospinal Fluid Biomarkers

Rationale for a Swedish cohort consortium

Sundström, Johan; Björkelund, Cecilia; Giedraitis, Vilmantas; Hansson, Per-Olof et al.

Ingår i Upsala Journal of Medical Sciences, s. 21-28, 2019

• DOI för Rationale for a Swedish cohort consortium
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Improved Differential Diagnosis of Alzheimer's Disease by Integrating ELISA and Mass Spectrometry-Based Cerebrospinal Fluid Biomarkers

Emami Khoonsari, Payam; Shevchenko, Ganna; Herman, Stephanie; Remnestal, Julia et al.

Ingår i Journal of Alzheimer's Disease, s. 639-651, 2019

• DOI för Improved Differential Diagnosis of Alzheimer's Disease by Integrating ELISA and Mass Spectrometry-Based Cerebrospinal Fluid Biomarkers
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Circulating proteins as predictors of incident heart failure in the elderly

Stenemo, Markus; Nowak, Christoph; Byberg, Liisa; Sundström, Johan et al.

Ingår i European Journal of Heart Failure, s. 55-62, 2018

• DOI för Circulating proteins as predictors of incident heart failure in the elderly

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Mahajan, Anubha; Taliun, Daniel; Thurner, Matthias; Robertson, Neil R. et al.

Ingår i Nature Genetics, s. 1505-+, 2018

• DOI för Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

Ligthart, Symen; Vaez, Ahmad; Võsa, Urmo; Stathopoulou, Maria G et al.

Ingår i American Journal of Human Genetics, s. 691-706, 2018

• DOI för Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease

Gyorgy, Bence; Loov, Camilla; Zaborowski, Mikolaj P.; Takeda, Shuko et al.

Ingår i Molecular Therapy Nucleic Acids, s. 429-440, 2018

• DOI för CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease
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Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

Mahajan, Anubha; Wessel, Jennifer; Willems, Sara M.; Zhao, Wei et al.

Ingår i Nature Genetics, s. 559-571, 2018

• DOI för Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

Evangelou, Evangelos; Warren, Helen R; Mosen-Ansorena, David; Mifsud, Borbala et al.

Ingår i Nature Genetics, s. 1412-1425, 2018

• DOI för Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Turcot, Valerie; Lu, Yingchang; Highland, Heather M.; Schurmann, Claudia et al.

Ingår i Nature Genetics, s. 26-+, 2018

• DOI för Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Glucose challenge metabolomics implicates medium-chain acylcarnitines in insulin resistance

Nowak, Christoph; Hetty, Susanne; Salihovic, Samira; Castillejo-Lopez, Casimiro et al.

Ingår i Scientific Reports, 2018

• DOI för Glucose challenge metabolomics implicates medium-chain acylcarnitines in insulin resistance
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Multiplex proteomics for prediction of major cardiovascular events in type 2 diabetes

Nowak, Christoph; Carlsson, Axel C; Östgren, Carl Johan; Nyström, Fredrik H. et al.

Ingår i Diabetologia, s. 1748-1757, 2018

• DOI för Multiplex proteomics for prediction of major cardiovascular events in type 2 diabetes
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Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

Wain, Louise V.; Vaez, Ahmad; Jansen, Rick; Joehanes, Roby et al.

Ingår i Hypertension, 2017

• DOI för Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Flannick, Jason; Fuchsberger, Christian; Mahajan, Anubha; Teslovich, Tanya M. et al.

Ingår i Scientific Data, 2017

• DOI för Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
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Rare and low-frequency coding variants alter human adult height

Marouli, Eirini; Graff, Mariaelisa; Medina-Gomez, Carolina; Lo, Ken Sin et al.

Ingår i Nature, s. 186-190, 2017

• DOI för Rare and low-frequency coding variants alter human adult height

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Sims, Rebecca; van der Lee, Sven J.; Naj, Adam C.; Bellenguez, Celine et al.

Ingår i Nature Genetics, s. 1373-+, 2017

• DOI för Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Cognitive function in very old men does not correlate to biomarkers of Alzheimer's disease

Velickaite, Vilma; Giedraitis, Vilmantas; Ström, K; Alafuzoff, Irina et al.

Ingår i BMC Geriatrics, 2017

• DOI för Cognitive function in very old men does not correlate to biomarkers of Alzheimer's disease
• Ladda ner fulltext (pdf) av Cognitive function in very old men does not correlate to biomarkers of Alzheimer's disease

Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Nolte, Ilja M.; Munoz, M. Loretto; Tragante, Vinicius; Amare, Azmeraw T. et al.

Ingår i Nature Communications, 2017

• DOI för Genetic loci associated with heart rate variability and their effects on cardiac disease risk
• Ladda ner fulltext (pdf) av Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Stability of Proteins in Dried Blood Spot Biobanks.

Björkesten, Johan; Enroth, Stefan; Shen, Qiujin; Wik, Lotta et al.

Ingår i Molecular & Cellular Proteomics, s. 1286-1296, 2017

• DOI för Stability of Proteins in Dried Blood Spot Biobanks.
• Ladda ner fulltext (pdf) av Stability of Proteins in Dried Blood Spot Biobanks.

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

Warren, Helen R.; Evangelou, Evangelos; Cabrera, Claudia P.; Gao, He et al.

Ingår i Nature Genetics, s. 403-415, 2017

• DOI för Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity

Mahajan, Anubha; Rodan, Aylin R.; Le, Thu H.; Gaulton, Kyle J. et al.

Ingår i American Journal of Human Genetics, s. 636-646, 2016

• DOI för Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity
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No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis

Loley, Christina; Alver, Maris; Assimes, Themistocles L.; Bjonnes, Andrew et al.

Ingår i Scientific Reports, 2016

• DOI för No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis
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Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study

Nowak, Christoph; Salihovic, Samira; Ganna, Andrea; Brandmaier, Stefan et al.

Ingår i PLOS Genetics, 2016

• DOI för Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study
• Ladda ner fulltext (pdf) av Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study

Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease

Dumanski, Jan P.; Lambert, Jean-Charles; Rasi, Chiara; Giedraitis, Vilmantas et al.

Ingår i American Journal of Human Genetics, s. 1208-1219, 2016

• DOI för Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease
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Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study

van der Laan, Sander W.; Fall, Tove; Soumare, Aicha; Teumer, Alexander et al.

Ingår i Journal of the American College of Cardiology, s. 934-945, 2016

• DOI för Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study
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The genetic architecture of type 2 diabetes

Fuchsberger, Christian; Flannick, Jason; Teslovich, Tanya M.; Mahajan, Anubha et al.

Ingår i Nature, s. 41-47, 2016

• DOI för The genetic architecture of type 2 diabetes

Non-targeted metabolomics combined with genetic analyses identifies bile acid synthesis and phospholipid metabolism as being associated with incident type 2 diabetes

Fall, Tove; Salihovic, Samira; Brandmaier, Stefan; Nowak, Christoph et al.

Ingår i Diabetologia, s. 2114-2124, 2016

• DOI för Non-targeted metabolomics combined with genetic analyses identifies bile acid synthesis and phospholipid metabolism as being associated with incident type 2 diabetes

Protein Biomarkers for Insulin Resistance and Type 2 Diabetes Risk in Two Large Community Cohorts

Nowak, Christoph; Sundström, Johan; Gustafsson, Stefan; Giedraitis, Vilmantas et al.

Ingår i Diabetes, s. 276-284, 2016

• DOI för Protein Biomarkers for Insulin Resistance and Type 2 Diabetes Risk in Two Large Community Cohorts

Mutagenesis: smoking is associated with mosaic loss of chromosome Y

Dumanski, Jan P.; Rasi, Chiara; Lönn, Mikael; Davies, Hanna et al.

Ingår i Science, s. 81-83, 2015

• DOI för Mutagenesis: smoking is associated with mosaic loss of chromosome Y

Self-reported sleep disturbance is associated with Alzheimer's disease risk in men

Benedict, Christian; Byberg, Liisa; Cedernaes, Jonathan; Hogenkamp, Pleunie S et al.

Ingår i Alzheimer's & Dementia, s. 1090-1097, 2015

• DOI för Self-reported sleep disturbance is associated with Alzheimer's disease risk in men
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Age- and sex-specific causal effects of adiposity on cardiovascular risk factors

Fall, Tove; Hägg, Sara; Ploner, Alexander; Mägi, Reedik et al.

Ingår i Diabetes, s. 1841-1852, 2015

• DOI för Age- and sex-specific causal effects of adiposity on cardiovascular risk factors

New genetic loci link adipose and insulin biology to body fat distribution

Shungin, Dmitry; Winkler, Thomas W; Croteau-Chonka, Damien C; Ferreira, Teresa et al.

Ingår i Nature, s. 187-196, 2015

• DOI för New genetic loci link adipose and insulin biology to body fat distribution

Adiposity as a cause of cardiovascular disease: a Mendelian randomization study

Hägg, Sara; Fall, Tove; Ploner, Alexander; Maegi, Reedik et al.

Ingår i International Journal of Epidemiology, s. 578-586, 2015

• DOI för Adiposity as a cause of cardiovascular disease: a Mendelian randomization study

Genetic studies of body mass index yield new insights for obesity biology

Locke, Adam E; Kahali, Bratati; Berndt, Sonja I; Justice, Anne E et al.

Ingår i Nature, s. 197-206, 2015

• DOI för Genetic studies of body mass index yield new insights for obesity biology

eta-Secretase processing of APP inhibits neuronal activity in the hippocampus

Willem, Michael; Tahirovic, Sabina; Busche, Marc Aurel; Ovsepian, Saak V. et al.

Ingår i Nature, s. 443-447, 2015

• DOI för eta-Secretase processing of APP inhibits neuronal activity in the hippocampus

Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independently of obesity

Scott, Robert A; Fall, Tove; Pasko, Dorota; Barker, Adam et al.

Ingår i Diabetes, s. 4378-4387, 2014

• DOI för Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independently of obesity

Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer

Forsberg, Lars A.; Rasi, Chiara; Malmqvist, Niklas; Davies, Hanna et al.

Ingår i Nature Genetics, s. 624-628, 2014

• DOI för Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer

Defining the role of common variation in the genomic and biological architecture of adult human height

Wood, Andrew R; Esko, Tonu; Yang, Jian; Vedantam, Sailaja et al.

Ingår i Nature Genetics, s. 1173-1186, 2014

• DOI för Defining the role of common variation in the genomic and biological architecture of adult human height

Acute sleep deprivation increases serum levels of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in healthy young men

Benedict, Christian; Cedernaes, Jonathan; Giedraitis, Vilmantas; Nilsson, Emil K et al.

Ingår i Sleep, s. 195-198, 2014

• DOI för Acute sleep deprivation increases serum levels of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in healthy young men

Rare Variants in Calcium Homeostasis Modulator 1 (CALHM1) Found in Early Onset Alzheimer's Disease Patients Alter Calcium Homeostasis

Rubio-Moscardo, Fanny; Seto-Salvia, Nuria; Pera, Marta; Bosch-Morato, Monica et al.

Ingår i PLOS ONE, 2013

• DOI för Rare Variants in Calcium Homeostasis Modulator 1 (CALHM1) Found in Early Onset Alzheimer's Disease Patients Alter Calcium Homeostasis
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Age-related accumulation of somatic structural changes in the nuclear genome of human blood cells in vivo

Dumanski, Jan P.; Forsberg, L. A.; Rasi, C.; Razzaghian, H. R. et al.

Ingår i Journal of Medical Genetics, 2012

Age-related somatic structural changes in the nuclear genome of human blood cells

Forsberg, Lars A.; Rasi, Chiara; Razzaghian, Hamid R; Pakalapati, Geeta et al.

Ingår i American Journal of Human Genetics, s. 217-228, 2012

• DOI för Age-related somatic structural changes in the nuclear genome of human blood cells

Neurofilament ELISA validation

Petzold, Axel; Altintas, Ayse; Andreoni, Laura; Bartos, Ales et al.

Ingår i JIM - Journal of Immunological Methods, s. 23-31, 2010

• DOI för Neurofilament ELISA validation

CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid

Giedraitis, Vilmantas; Glaser, Anna; Sarajärvi, Timo; Brundin, RoseMarie et al.

Ingår i Neuroscience Letters, s. 265-267, 2010

• DOI för CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid

Cystatin C Levels are Positively Correlated with both Aβ₄₂ and Tau Levels in Cerebrospinal Fluid in Persons with Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Controls

Sundelöf, Johan; Sundstrom, Johan; Hansson, Oskar; Eriksdotter-Jönhagen, Maria et al.

Ingår i Journal of Alzheimer's Disease, s. 471-478, 2010

• DOI för Cystatin C Levels are Positively Correlated with both Aβ₄₂ and Tau Levels in Cerebrospinal Fluid in Persons with Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Controls

Higher Cathepsin B Levels in Plasma in Alzheimer's Disease Compared to Healthy Controls

Sundelöf, Johan; Sundström, Johan; Hansson, Oskar; Eriksdotter-Jönhagen, Maria et al.

Ingår i Journal of Alzheimer's Disease, s. 1223-1230, 2010

• DOI för Higher Cathepsin B Levels in Plasma in Alzheimer's Disease Compared to Healthy Controls

The CALHM1 P86L Polymorphism is a Genetic Modifier of Age at Onset in Alzheimer's Disease: a Meta-Analysis Study

Lambert, Jean-Charles; Sleegers, Kristel; Gonzalez-Perez, Antonio; Ingelsson, Martin et al.

Ingår i Journal of Alzheimer's Disease, s. 247-255, 2010

• DOI för The CALHM1 P86L Polymorphism is a Genetic Modifier of Age at Onset in Alzheimer's Disease: a Meta-Analysis Study

Further analysis of previously implicated linkage regions for Alzheimer’s disease in affected relative pairs

Blom, Elin Susanne; Giedraitis, Vilmantas; Arepalli, Sampath; Hamshere, Marian L. et al.

Ingår i BMC Medical Genetics, s. 122, 2009

• DOI för Further analysis of previously implicated linkage regions for Alzheimer’s disease in affected relative pairs

Frontotemporal dementia in a large Swedish family is caused by a progranulin null mutation

Skoglund, Lena; Brundin, RoseMarie; Olofsson, Tommie; Kalimo, Hannu et al.

Ingår i Neurogenetics, s. 27-34, 2009

• DOI för Frontotemporal dementia in a large Swedish family is caused by a progranulin null mutation

Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men

Giedraitis, Vilmantas; Kilander, Lena; Degerman-Gunnarsson, Malin; Sundelöf, Johan et al.

Ingår i Dementia and Geriatric Cognitive Disorders, s. 59-68, 2009

• DOI för Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men

No evidence of PGRN or MAPT gene dosage alterations in a collection of patients with frontotemporal lobar degeneration

Skoglund, Lena; Ingvast, Sofie; Matsui, Toshifumi; Freeman, Stefanie et al.

Ingår i Dementia and Geriatric Cognitive Disorders, s. 471-475, 2009

• DOI för No evidence of PGRN or MAPT gene dosage alterations in a collection of patients with frontotemporal lobar degeneration

Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype

Blom, Elin S.; Giedraitis, Vilmantas; Zetterberg, Henrik; Fukumoto, Hiroaki et al.

Ingår i Dementia and Geriatric Cognitive Disorders, s. 458-464, 2009

• DOI för Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype

Serum cystatin C and the risk of Alzheimer disease in elderly men

Sundelöf, Johan; Ärnlöv, J.; Ingelsson, E.; Sundström, J. et al.

Ingår i Neurology, s. 1072-1079, 2008

• DOI för Serum cystatin C and the risk of Alzheimer disease in elderly men

Plasma β Amyloid and the Risk of Alzheimer Disease and Dementia in Elderly Men: A Prospective, Population-Based Cohort Study

Sundelöf, Johan; Giedraitis, Vilmantas; Irizarry, Michael C; Sundström, Johan et al.

Ingår i Archives of Neurology, s. 256-63, 2008

• DOI för Plasma β Amyloid and the Risk of Alzheimer Disease and Dementia in Elderly Men: A Prospective, Population-Based Cohort Study

The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer's disease

Giedraitis, Vilmantas; Sundelöf, Johan; Irizarry, Michael C; Gårevik, Nina et al.

Ingår i Neuroscience Letters, s. 127-131, 2007

• DOI för The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer's disease

Association study of cholesterol-related genes in Alzheimer's disease

Wollmer, M Axel.; Sleegers, Kristel; Ingelsson, Martin; Zekanowski, Cezary et al.

Ingår i Neurogenetics, s. 179-188, 2007

• DOI för Association study of cholesterol-related genes in Alzheimer's disease

New Alzheimer's disease locus on chromosome 8

Giedraitis, Vilmantas; Hedlund, M.; Skoglund, Lena; Blom, Elin et al.

Ingår i Journal of Medical Genetics, s. 931-935, 2006

• DOI för New Alzheimer's disease locus on chromosome 8

Adult-onset autosomal dominant leukodystrophy with autonomic symptoms restricted to 1.5 Mbp on chromosome 5q23

Marklund, Lena; Melin, Malin; Melberg, Atle; Giedraitis, Vilmantas et al.

Ingår i American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, s. 608-614, 2006

• DOI för Adult-onset autosomal dominant leukodystrophy with autonomic symptoms restricted to 1.5 Mbp on chromosome 5q23

The Uppsala APP deletion causes early onset autosomal dominant Alzheimer’s disease by altering APP processing and increasing amyloid-β fibril formation

Pagnon de la Vega, María; Giedraitis, Vilmantas; Michno, Wojciech; Kilander, Lena et al.

Ingår i Science Translational Medicine

Step length during Timed Up and Go performance – preliminary results of a cross-sectional cohort study.

Roseberg Petersson, Johanna; Berglund, Lars; Giedraitis, Vilmantas; Halvorsen, Kjartan et al.

2023

Prediction of conversion to dementia disorders based on Timed Up and Go dual-task test verbal outcomes: A longitudinal prospective memory-clinic-based study

Åberg, Anna Cristina; Roseberg Petersson, Johanna; Giedraitis, Vilmantas; McKee, Kevin et al.

2023

The Uppsala APP mutation promotes wildtype Aβ aggregation and deposition in vivo

Pagnon de la Vega, María; Ge, Junyue; Giedraitis, Vilmantas; Syvänen, Stina et al.

Transgenic mice harboring the Uppsala APP mutation display altered APP processing and accelerated Aβ42 pathology with distinct structural features

Pagnon de la Vega, María; Syvänen, Stina; Hooley, Monique; Giedraitis, Vilmantas et al.

CRISPR/Cas9 as a tool to disrupt wild-type and A53T SNCA in sporadic and familial Parkinson’s disease

Molisak, Agnieszka; Konstantinidis, Evangelos; Aguilar, Ximena; Giedraitis, Vilmantas et al.

Metabolite profiles during an oral glucose tolerance test reveal new associations with clamp-measured insulin sensitivity

Nowak, Christoph; Sundstrom, Johan; Salihovic, Samira; Ganna, Andrea et al.

• Ladda ner fulltext (pdf) av Metabolite profiles during an oral glucose tolerance test reveal new associations with clamp-measured insulin sensitivity