Kailash Singh

Diabetic complications and prospective immunotherapy

Reynolds, Lewis; Luo, Zhengkang; Singh, Kailash

Ingår i Frontiers in Immunology, 2023

• DOI för Diabetic complications and prospective immunotherapy
• Ladda ner fulltext (pdf) av Diabetic complications and prospective immunotherapy

Interleukin-35 Prevents the Elevation of the M1/M2 Ratio of Macrophages in Experimental Type 1 Diabetes

Luo, Zhengkang; Soläng, Charlotte; Larsson, Rasmus; Singh, Kailash

Ingår i International Journal of Molecular Sciences, 2022

• DOI för Interleukin-35 Prevents the Elevation of the M1/M2 Ratio of Macrophages in Experimental Type 1 Diabetes
• Ladda ner fulltext (pdf) av Interleukin-35 Prevents the Elevation of the M1/M2 Ratio of Macrophages in Experimental Type 1 Diabetes

Gene Delivery of Manf to Beta-Cells of the Pancreatic Islets Protects NOD Mice from Type 1 Diabetes Development

Singh, Kailash; Bricard, Orian; Haughton, Jeason; Björkqvist, Mikaela et al.

Ingår i Biomolecules, 2022

• DOI för Gene Delivery of Manf to Beta-Cells of the Pancreatic Islets Protects NOD Mice from Type 1 Diabetes Development
• Ladda ner fulltext (pdf) av Gene Delivery of Manf to Beta-Cells of the Pancreatic Islets Protects NOD Mice from Type 1 Diabetes Development

Interleukin-35 Prevents Development of Autoimmune Diabetes Possibly by Maintaining the Phenotype of Regulatory B Cells

Luo, Zhengkang; Lundin, Sara; Mejia Cordova, Mariela; Hassani, Imane et al.

Ingår i International Journal of Molecular Sciences, 2021

• DOI för Interleukin-35 Prevents Development of Autoimmune Diabetes Possibly by Maintaining the Phenotype of Regulatory B Cells
• Ladda ner fulltext (pdf) av Interleukin-35 Prevents Development of Autoimmune Diabetes Possibly by Maintaining the Phenotype of Regulatory B Cells

Cellular immunological changes in patients with LADA are a mixture of those seen in patients with type 1 and type 2 diabetes

Singh, Kailash; Martinell, Mats; Luo, Zhengkang; Espes, Daniel et al.

Ingår i Clinical and Experimental Immunology, s. 64-73, 2019

• DOI för Cellular immunological changes in patients with LADA are a mixture of those seen in patients with type 1 and type 2 diabetes
• Ladda ner fulltext (pdf) av Cellular immunological changes in patients with LADA are a mixture of those seen in patients with type 1 and type 2 diabetes

Increased Interleukin-35 Levels in Patients With Type 1 Diabetes With Remaining C-Peptide

Espes, Daniel; Singh, Kailash; Sandler, Stellan; Carlsson, Per-Ola

Ingår i Diabetes Care, s. 1090-1095, 2017

• DOI för Increased Interleukin-35 Levels in Patients With Type 1 Diabetes With Remaining C-Peptide

Concomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naive mice

Singh, Kailash; Hjort, Marcus; Thorvaldson, Lina; Sandler, Stellan

Ingår i Scientific Reports, s. 7767, 2015

• DOI för Concomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naive mice
• Ladda ner fulltext (pdf) av Concomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naive mice

Interleukin-35 administration counteracts established murine type 1 diabetes - possible involvement of regulatory T cells

Singh, Kailash; Kadesjö, Erik; Lindroos, Julia; Hjort, Marcus et al.

Ingår i Scientific Reports, 2015

• DOI för Interleukin-35 administration counteracts established murine type 1 diabetes - possible involvement of regulatory T cells
• Ladda ner fulltext (pdf) av Interleukin-35 administration counteracts established murine type 1 diabetes - possible involvement of regulatory T cells

Regulatory T cells: the 2025 Nobel prize in physiology or medicine

Singh, Kailash

Ingår i Upsala Journal of Medical Sciences, 2026

• DOI för Regulatory T cells: the 2025 Nobel prize in physiology or medicine
• Ladda ner fulltext (pdf) av Regulatory T cells: the 2025 Nobel prize in physiology or medicine

Gene delivery of immunomodulatory cytokines to the lung preserves respiratory function during inflammatory challenge

Makuyana, Ntombizodwa; Seldeslachts, Laura; Michiels, Lauren; Burton, Oliver T. et al.

Ingår i Science immunology, 2026

• DOI för Gene delivery of immunomodulatory cytokines to the lung preserves respiratory function during inflammatory challenge

Proximity extension assay inflammatory profiling cannot distinguish the presence of residual C-peptide in patients with long-standing type 1 diabetes

Anvari, Ebrahim; Lundkvist, Per; Singh, Kailash; Espes, Daniel

Ingår i Acta Diabetologica, s. 1987-1996, 2025

• DOI för Proximity extension assay inflammatory profiling cannot distinguish the presence of residual C-peptide in patients with long-standing type 1 diabetes
• Ladda ner fulltext (pdf) av Proximity extension assay inflammatory profiling cannot distinguish the presence of residual C-peptide in patients with long-standing type 1 diabetes

Chromogranin A and catestatin regulate pancreatic islet homeostasis, endocrine function, and neurotransmitter signaling

Muntjewerff, Elke M.; Epremidze, Dali; Nezhyva, Mariya; Kal, Satadeepa et al.

Ingår i Communications Biology, 2025

• DOI för Chromogranin A and catestatin regulate pancreatic islet homeostasis, endocrine function, and neurotransmitter signaling
• Ladda ner fulltext (pdf) av Chromogranin A and catestatin regulate pancreatic islet homeostasis, endocrine function, and neurotransmitter signaling

Assessing the Effectiveness of Interleukin-2 Therapy in Experimental Type 1 Diabetes

Luo, Zhengkang; Mejia Cordova, Mariela; Hamze, Nour; Berggren, Elin et al.

Ingår i Endocrine, s. 626-637, 2024

• DOI för Assessing the Effectiveness of Interleukin-2 Therapy in Experimental Type 1 Diabetes
• Ladda ner fulltext (pdf) av Assessing the Effectiveness of Interleukin-2 Therapy in Experimental Type 1 Diabetes

Regulatory T cells: the 2025 Nobel prize in physiology or medicine

Singh, Kailash

Ingår i Upsala Journal of Medical Sciences, 2026

• DOI för Regulatory T cells: the 2025 Nobel prize in physiology or medicine
• Ladda ner fulltext (pdf) av Regulatory T cells: the 2025 Nobel prize in physiology or medicine

Gene delivery of immunomodulatory cytokines to the lung preserves respiratory function during inflammatory challenge

Makuyana, Ntombizodwa; Seldeslachts, Laura; Michiels, Lauren; Burton, Oliver T. et al.

Ingår i Science immunology, 2026

• DOI för Gene delivery of immunomodulatory cytokines to the lung preserves respiratory function during inflammatory challenge

Proximity extension assay inflammatory profiling cannot distinguish the presence of residual C-peptide in patients with long-standing type 1 diabetes

Anvari, Ebrahim; Lundkvist, Per; Singh, Kailash; Espes, Daniel

Ingår i Acta Diabetologica, s. 1987-1996, 2025

• DOI för Proximity extension assay inflammatory profiling cannot distinguish the presence of residual C-peptide in patients with long-standing type 1 diabetes
• Ladda ner fulltext (pdf) av Proximity extension assay inflammatory profiling cannot distinguish the presence of residual C-peptide in patients with long-standing type 1 diabetes

Chromogranin A and catestatin regulate pancreatic islet homeostasis, endocrine function, and neurotransmitter signaling

Muntjewerff, Elke M.; Epremidze, Dali; Nezhyva, Mariya; Kal, Satadeepa et al.

Ingår i Communications Biology, 2025

• DOI för Chromogranin A and catestatin regulate pancreatic islet homeostasis, endocrine function, and neurotransmitter signaling
• Ladda ner fulltext (pdf) av Chromogranin A and catestatin regulate pancreatic islet homeostasis, endocrine function, and neurotransmitter signaling

Assessing the Effectiveness of Interleukin-2 Therapy in Experimental Type 1 Diabetes

Luo, Zhengkang; Mejia Cordova, Mariela; Hamze, Nour; Berggren, Elin et al.

Ingår i Endocrine, s. 626-637, 2024

• DOI för Assessing the Effectiveness of Interleukin-2 Therapy in Experimental Type 1 Diabetes
• Ladda ner fulltext (pdf) av Assessing the Effectiveness of Interleukin-2 Therapy in Experimental Type 1 Diabetes

Investigating the effects of radiation, T cell depletion, and bone marrow transplantation on murine gut microbiota

Kreisinger, Jakub; Dooley, James; Singh, Kailash; Cízková, Dagmar et al.

Ingår i Frontiers in Microbiology, 2024

• DOI för Investigating the effects of radiation, T cell depletion, and bone marrow transplantation on murine gut microbiota
• Ladda ner fulltext (pdf) av Investigating the effects of radiation, T cell depletion, and bone marrow transplantation on murine gut microbiota

Interleukin-35 Prevents the Elevation of the M1/M2 Ratio of Macrophages in Experimental Type 1 Diabetes

Luo, Zhengkang; Soläng, Charlotte; Larsson, Rasmus; Singh, Kailash

Ingår i International Journal of Molecular Sciences, 2022

• DOI för Interleukin-35 Prevents the Elevation of the M1/M2 Ratio of Macrophages in Experimental Type 1 Diabetes
• Ladda ner fulltext (pdf) av Interleukin-35 Prevents the Elevation of the M1/M2 Ratio of Macrophages in Experimental Type 1 Diabetes

Gene Delivery of Manf to Beta-Cells of the Pancreatic Islets Protects NOD Mice from Type 1 Diabetes Development

Singh, Kailash; Bricard, Orian; Haughton, Jeason; Björkqvist, Mikaela et al.

Ingår i Biomolecules, 2022

• DOI för Gene Delivery of Manf to Beta-Cells of the Pancreatic Islets Protects NOD Mice from Type 1 Diabetes Development
• Ladda ner fulltext (pdf) av Gene Delivery of Manf to Beta-Cells of the Pancreatic Islets Protects NOD Mice from Type 1 Diabetes Development

Interleukin-35 Prevents Development of Autoimmune Diabetes Possibly by Maintaining the Phenotype of Regulatory B Cells

Luo, Zhengkang; Lundin, Sara; Mejia Cordova, Mariela; Hassani, Imane et al.

Ingår i International Journal of Molecular Sciences, 2021

• DOI för Interleukin-35 Prevents Development of Autoimmune Diabetes Possibly by Maintaining the Phenotype of Regulatory B Cells
• Ladda ner fulltext (pdf) av Interleukin-35 Prevents Development of Autoimmune Diabetes Possibly by Maintaining the Phenotype of Regulatory B Cells

Significance of host heparanase in promoting tumor growth and metastasis

Zhang, Gan-Lin; Gutter-Kapon, Lilach; Ilan, Neta; Batool, Tahira et al.

Ingår i Matrix Biology, s. 25-42, 2020

• DOI för Significance of host heparanase in promoting tumor growth and metastasis

Determination of Regulatory T Cell Subsets in Murine Thymus, Pancreatic Draining Lymph Node and Spleen Using Flow Cytometry

Luo, Zhengkang; Thorvaldson, Lina; Blixt, Martin; Singh, Kailash

Ingår i Journal of Visualized Experiments, 2019

• DOI för Determination of Regulatory T Cell Subsets in Murine Thymus, Pancreatic Draining Lymph Node and Spleen Using Flow Cytometry

The Cdh5-CreERT2 transgene causes conditional Shb gene deletion in hematopoietic cells with consequences for immune cell responses to tumors

He, Qi; Li, Xiujuan; Singh, Kailash; Luo, Zhengkang et al.

Ingår i Scientific Reports, 2019

• DOI för The Cdh5-CreERT2 transgene causes conditional Shb gene deletion in hematopoietic cells with consequences for immune cell responses to tumors
• Ladda ner fulltext 1 (pdf) av The Cdh5-CreERT2 transgene causes conditional Shb gene deletion in hematopoietic cells with consequences for immune cell responses to tumors
• Ladda ner fulltext 2 (pdf) av The Cdh5-CreERT2 transgene causes conditional Shb gene deletion in hematopoietic cells with consequences for immune cell responses to tumors

Kinetics of immune cell responses in the multiple low dose streptozotocin mouse model of type 1 diabetes

Luo, Zhengkang; Soläng, Charlotte; Mejia Cordova, Mariela; Thorvaldson, Lina et al.

Ingår i FASEB BioAdvances, s. 538-549, 2019

• DOI för Kinetics of immune cell responses in the multiple low dose streptozotocin mouse model of type 1 diabetes
• Ladda ner fulltext (pdf) av Kinetics of immune cell responses in the multiple low dose streptozotocin mouse model of type 1 diabetes

Cellular immunological changes in patients with LADA are a mixture of those seen in patients with type 1 and type 2 diabetes

Singh, Kailash; Martinell, Mats; Luo, Zhengkang; Espes, Daniel et al.

Ingår i Clinical and Experimental Immunology, s. 64-73, 2019

• DOI för Cellular immunological changes in patients with LADA are a mixture of those seen in patients with type 1 and type 2 diabetes
• Ladda ner fulltext (pdf) av Cellular immunological changes in patients with LADA are a mixture of those seen in patients with type 1 and type 2 diabetes

Pro-tumoral immune cell alterations in wild type and Shb-deficient mice in response to 4T1 breast carcinomas

Li, Xiujuan; Singh, Kailash; Luo, Zhengkang; Mejia Cordova, Mariela et al.

Ingår i Oncotarget, s. 18720-18733, 2018

• DOI för Pro-tumoral immune cell alterations in wild type and Shb-deficient mice in response to 4T1 breast carcinomas
• Ladda ner fulltext (pdf) av Pro-tumoral immune cell alterations in wild type and Shb-deficient mice in response to 4T1 breast carcinomas

Overexpression of heparanase enhances T lymphocyte activities and intensifies the inflammatory response in a model of murine rheumatoid arthritis

Digre, Andreas; Singh, Kailash; Åbrink, Magnus; Reijmers, Rogier M. et al.

Ingår i Scientific Reports, 2017

• DOI för Overexpression of heparanase enhances T lymphocyte activities and intensifies the inflammatory response in a model of murine rheumatoid arthritis
• Ladda ner fulltext (pdf) av Overexpression of heparanase enhances T lymphocyte activities and intensifies the inflammatory response in a model of murine rheumatoid arthritis

Kinetics of innate immune and regulatory T cells responses in experimental diabetic nephropathy

Luo, Zhengkang; Varli, Sonya; Enström, Emma; Thorvaldson, Lina et al.

Ingår i Scandinavian Journal of Immunology, s. 304-304, 2017

Kinetics of the innate immune cell responses in experimental Type 1 Diabetes

Mejia Cordova, Mariela; Soläng, Charlotte; Luo, Zhengkang; Blixt, Martin et al.

Ingår i Scandinavian Journal of Immunology, s. 303-304, 2017

The Increased Circulating Plasma Levels of Vascular Endothelial Growth Factor in Patients with Type 1 Diabetes Do Not Correlate to Metabolic Control

Singh, Kailash; Sandler, Stellan; Espes, Daniel

Ingår i Journal of Diabetes Research, 2017

• DOI för The Increased Circulating Plasma Levels of Vascular Endothelial Growth Factor in Patients with Type 1 Diabetes Do Not Correlate to Metabolic Control
• Ladda ner fulltext (pdf) av The Increased Circulating Plasma Levels of Vascular Endothelial Growth Factor in Patients with Type 1 Diabetes Do Not Correlate to Metabolic Control

Role of regulatory B cells in clinical and experimental type 1 diabetes

Lundin, Sara; Espes, Daniel; Luo, Zhenkang; Blixt, Martin et al.

Ingår i Scandinavian Journal of Immunology, s. 349-349, 2017

Increased Interleukin-35 Levels in Patients With Type 1 Diabetes With Remaining C-Peptide

Espes, Daniel; Singh, Kailash; Sandler, Stellan; Carlsson, Per-Ola

Ingår i Diabetes Care, s. 1090-1095, 2017

• DOI för Increased Interleukin-35 Levels in Patients With Type 1 Diabetes With Remaining C-Peptide

Kinetics of the Foxp3(+) cell response in kidney tissue of both autoimmune and non-autoimmune induced hyperglycemia in mice

Varli, Sonya; Thorvaldson, Lina; Sandler, Stellan; Singh, Kailash

Ingår i European Journal of Immunology, s. 1065-1065, 2016

Concomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naive mice

Singh, Kailash; Hjort, Marcus; Thorvaldson, Lina; Sandler, Stellan

Ingår i Scientific Reports, s. 7767, 2015

• DOI för Concomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naive mice
• Ladda ner fulltext (pdf) av Concomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naive mice

Interleukin-35 administration counteracts established murine type 1 diabetes - possible involvement of regulatory T cells

Singh, Kailash; Kadesjö, Erik; Lindroos, Julia; Hjort, Marcus et al.

Ingår i Scientific Reports, 2015

• DOI för Interleukin-35 administration counteracts established murine type 1 diabetes - possible involvement of regulatory T cells
• Ladda ner fulltext (pdf) av Interleukin-35 administration counteracts established murine type 1 diabetes - possible involvement of regulatory T cells

Heparan Sulfate Proteoglycans Are Important for Islet Amyloid Formation and Islet Amyloid Polypeptide-induced Apoptosis

Oskarsson, Marie E.; Singh, Kailash; Wang, Jian; Vlodavsky, Israel et al.

Ingår i Journal of Biological Chemistry, s. 15121-15132, 2015

• DOI för Heparan Sulfate Proteoglycans Are Important for Islet Amyloid Formation and Islet Amyloid Polypeptide-induced Apoptosis

The Kinetics of Thymic-Derived and Peripherally Induced Regulatory T Cell Response in Early Development of Type 1 Diabetes in a Murine Experimental Model

Singh, Kailash; Lundberg, Marcus; Thorvaldson, Lina; Sandler, Stellan

Ingår i Scandinavian Journal of Immunology, s. 447-447, 2014

Functional Impairment of Regulatory T Cells in the Early Development of T1D in the MLDSTZ Murine Model

Singh, Kailash; Kadesjo, E.; Lindroos, J.; Eriksson, F. E. et al.

Ingår i Scandinavian Journal of Immunology, s. 286-286, 2013

Kinetics of regulatory T cells in early development of type 1 diabetes in MLDSTZ induced murine model

Singh, Kailash; Kadesjö, E.; Lindroos, J.; Sandler, Stellan et al.

Ingår i Immunology, s. 26-26, 2012

Diabetic complications and prospective immunotherapy

Reynolds, Lewis; Luo, Zhengkang; Singh, Kailash

Ingår i Frontiers in Immunology, 2023

• DOI för Diabetic complications and prospective immunotherapy
• Ladda ner fulltext (pdf) av Diabetic complications and prospective immunotherapy

Regulatory T cells in type 1 diabetes: the role of IL-35 in counteracting the disease

Singh, Kailash

2017

• Ladda ner fulltext (pdf) av Regulatory T cells in type 1 diabetes: the role of IL-35 in counteracting the disease

Characterization of Cellular Immunology in LADA Patients

Martinell, Mats; Singh, Kailash; Zhengkang, Luo; Espes, Daniel et al.