Peter Bergsten
Professor i med. cellbiologi, särskilt experimentell diabetesforskning vid Institutionen för medicinsk cellbiologi; Forskargrupp Peter Bergsten
- Telefon:
- 018-471 49 23
- Mobiltelefon:
- 070-870 22 10
- Fax:
- 018-471 40 59
- E-post:
- Peter.Bergsten@mcb.uu.se
- Besöksadress:
- BMC
Husargatan 3
751 23 Uppsala - Postadress:
- Box 571
751 23 UPPSALA
Affilierad Forskare vid Institutionen för kvinnors och barns hälsa; Pediatrisk inflammations- och metabolismforskning samt barnhälsa
- Telefon:
- 018-471 49 23
- Mobiltelefon:
- 070-870 22 10
- E-post:
- peter.bergsten@kbh.uu.se
- Besöksadress:
- MTC-huset, Dag Hammarskjölds väg 14B, 1 tr
752 37 Uppsala - Postadress:
- Akademiska sjukhuset
751 85 UPPSALA - Tillgänglig:
- barnspecialistmottagning, forskningsavd barn
- Akademiska meriter:
- DMSc, docent i med. cellbiologi
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Publikationer
Senaste publikationer
- Studies in children with obesity in two European treatment centres show a high prevalence of impaired glucose metabolism in the Swedish cohort (2024)
- GABA-mediated inhibition of human CD4+ T cell functions is enhanced by insulin but impaired by high glucose levels (2024)
- Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells (2024)
- Rise in fasting and dynamic glucagon levels in children and adolescents with obesity is moderate in subjects with impaired fasting glucose but accentuated in subjects with impaired glucose tolerance or type 2 diabetes (2024)
- Short-term effects of canagliflozin on glucose and insulin responses in insulin dysregulated horses (2023)
Alla publikationer
Artiklar
- Studies in children with obesity in two European treatment centres show a high prevalence of impaired glucose metabolism in the Swedish cohort (2024)
- GABA-mediated inhibition of human CD4+ T cell functions is enhanced by insulin but impaired by high glucose levels (2024)
- Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells (2024)
- Rise in fasting and dynamic glucagon levels in children and adolescents with obesity is moderate in subjects with impaired fasting glucose but accentuated in subjects with impaired glucose tolerance or type 2 diabetes (2024)
- Short-term effects of canagliflozin on glucose and insulin responses in insulin dysregulated horses (2023)
- Screening for inflammatory markers identifies IL18-Rα as a potential link between exenatide and its anti-inflammatory effect (2023)
- Adolescents with obesity treated with exenatide maintain endogenous GLP-1, reduce DPP-4, and improve glycemic control (2023)
- Low Fasting Concentrations of Glucagon in Patients with Very Long-Chain Acyl-CoA Dehydrogenase Deficiency (2023)
- Metformin restores prohormone processing enzymes and normalizes aberrations in secretion of proinsulin and insulin in palmitate‐exposed human islets (2023)
- Metformin Can Attenuate Beta-Cell Hypersecretion-Implications for Treatment of Children with Obesity (2023)
- High levels of FSH before puberty are associated with increased risk of metabolic syndrome during pubertal transition (2022)
- Deviating glucose results in an international dual-center study. A root cause investigation (2022)
- Single Point Insulin Sensitivity Estimator in Pediatric Non-Alcoholic Fatty Liver Disease (2022)
- Association between alanine aminotransferase as surrogate of fatty liver disease and physical activity and sedentary time in adolescents with obesity (2022)
- Sedentary time has a stronger impact on metabolic health than moderate to vigorous physical activity in adolescents with obesity (2022)
- Association between Metabolic Syndrome Diagnosis and the Physical Activity-Sedentary Profile of Adolescents with Obesity (2022)
- Determinants of hyperglucagonemia in pediatric non-alcoholic fatty liver disease (2022)
- Obesity in adolescents associated with vascular aging - a study using ultra-high-resolution ultrasound (2022)
- Altered mitochondrial metabolism in peripheral blood cells from patients with inborn errors of β-oxidation (2022)
- Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions (2022)
- The endoplasmic reticulum-plasma membrane tethering protein TMEM24 is a regulator of cellular Ca2+ homeostasis (2022)
- Prevalence of different states of glucose intolerance in Sri Lankan children and adolescents with obesity and its relation to other comorbidities. (2021)
- Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK (2021)
- Evaluation of fasting plasma insulin and proxy measurements to assess insulin sensitivity in horses (2021)
- Impaired HMG-CoA reductase activity caused by genetic variants or statin exposure (2021)
- Metabolic Abnormalities in a Cohort of Overweight and Obese Children in an Urban Setting of Sri Lanka (2021)
- Serum Ferritin Correlates With Liver Fat in Male Adolescents With Obesity. (2020)
- A 6-month randomized, double-blind, placebo-controlled trial of weekly exenatide in adolescents with obesity (2020)
- The importance of the ZBED6-IGF2 axis for metabolic regulation in mouse myoblast cells (2020)
- Fully convolutional networks for automated segmentation of abdominal adipose tissue depots in multicenter water–fat MRI (2019)
- Brown adipose tissue estimated with the magnetic resonance imaging fat fraction is associated with glucose metabolism in adolescents (2019)
- Hyperglucagonemia in youth is associated with high plasma free fatty acids, visceral adiposity and impaired glucose tolerance (2019)
- Developmental exposure to a very low dose of bisphenol A induces persistent islet insulin hypersecretion in Fischer 344 rat offspring (2019)
- Oleate increase neutral lipid accumulation, cellular respiration and rescues palmitate-exposed GLP-1 secreting cells by reducing ceramide-induced ROS (2019)
- Glucose Appearance Rate Rather than the Blood Glucose Concentrations Explains Differences in Postprandial Insulin Responses between Wholemeal Rye and Refined Wheat Breads-Results from A Cross-Over Meal Study (2019)
- The protein synthesis inhibitor brusatol normalizes high-fat diet-induced glucose intolerance in male C57BL/6 mice (2019)
- Assessment of Nutritional Status in Sri Lankan Children (2019)
- Mechanisms of beneficial effects of metformin on fatty acid-treated human islets (2018)
- Lysophosphatidylcholine and its phosphorothioate analogues potentiate insulin secretion via GPR40 (FFAR1), GPR55 and GPR119 receptors in a different manner (2018)
- Palmitate-Induced Insulin Hypersecretion and Later Secretory Decline Associated with Changes in Protein Expression Patterns in Human Pancreatic Islets (2018)
- The initial rise in GIP secretion during OGTT correlates with the initial suppression of glucagon secretion in adolescents with obesity and type 2 diabetes (2018)
- Identification of early biological changes in palmitate-treated isolated human islets. (2018)
- High DPP-4 concentrations in adolescents are associated with low intact GLP-1 (2018)
- Metformin restores insulin secretion from palmitate-treated human islets by normalising mitochondrial metabolism and reducing ER stress and apoptosis (2017)
- Childhood adiposity and risk of type 1 diabetes (2017)
- GLP-1 analogue recovers impaired insulin secretion from human islets treated with palmitate via down-regulation of SOCS2 (2017)
- Exenatide Once Weekly Reduces Weight, Liver Fat And 2-Hour Postprandial Glucose In Obese Adolescents (2017)
- Effect of Glucose Load on the Incretin Response (GLP-1) in obese Adolescents compared to the normal-weight Adolescents (2017)
- Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretion (2017)
- EndoC-beta H1 cells display increased sensitivity to sodium palmitate when cultured in DMEM/F12 medium (2017)
- Automated segmentation of human cervical-supraclavicular adipose tissue in magnetic resonance images (2017)
- TNFSF14 (2017)
- Association Between Non-Alcoholic Fatty Liver Disease (NAFLD) and Iron Metabolism in Obese Children and Adolescents (2017)
- Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolism (2017)
- Pancreatic Fat Is Associated With Metabolic Syndrome and Visceral Fat but Not Beta-Cell Function or Body Mass Index in Pediatric Obesity (2017)
- Fatty acids stimulate insulin secretion from human pancreatic islets at fasting glucose concentrations via mitochondria-dependent and -independent mechanisms (2016)
- Eating Behavior In Swedish And Austrian Children And Adolescents With Obesity (2016)
- Free fatty acids amplify basal secretion of both glucagon and insulin from isolated human islets at normoglycaemia via metabolic and FFAR1 dependent mechanism (2016)
- Hyperglucagonaemia is associated with elevated plasma triglycerides and increased visceral fat in children and adolescents (2016)
- Hyperglucagonemia is associated with a Increase of Plasma Triglycerides as well as visceral Fat Tissue in a pediatric Cohort (2016)
- Altered Plasma Levels of Glucagon, GLP-1 and Glicentin During OGTT in Adolescents With Obesity and Type 2 Diabetes (2016)
- Branched-chain amino acids are associated with cardiometabolic risk profiles found already in lean, overweight and obese young (2016)
- Modification and Validation of the Triglyceride-to-HDL Cholesterol Ratio as a Surrogate of Insulin Sensitivity in White Juveniles and Adults without Diabetes Mellitus (2016)
- Oleate protects beta cells from the toxic effect of palmitate by restoring pro-survival pathways of the ER stress response (2016)
- Oleate protects beta-cells from the toxic effect of palmitate by activating pro-survival pathways of the ER stress response (2016)
- Initial hyperinsulinemia and subsequent beta-cell dysfunction is associated with elevated palmitate levels (2016)
- Role of PIAS1 in palmitate mediated beta cell dysfunction (2015)
- Development of Glucose Intolerance in Obese Children Studied in the Beta-Judo Cohort (2015)
- Role of the AMP kinase in cytokine-induced human EndoC-beta H1 cell death (2015)
- Palmitate stimulates insulin secretion by enhancing mitochondrial respiration via intracellular metabolism and FFAR1 signalling (2015)
- Free fatty acid receptor 1 (FFAR1/GPR40) signaling affects insulin secretion by enhancing mitochondrial respiration during palmitate exposure (2015)
- Magnetic resonance imaging cooling–reheating protocol indicates decreased fat fraction via lipid consumption in suspected brown adipose tissue (2015)
- Palmitate-induced impairments of beta-cell function are linked with generation of specific ceramide species via acylation of sphingosine (2015)
- Early Adiposity Rebound and its Association with Obesity and Neuropsychiatric Disorders (2015)
- Active GLP-1 but not insulin, glicentin or glucagon predicts the 2-hour OGTT glucose value in obese children (2015)
- Deep Subcutaneous Adipose Tissue Correlates with Accentuated Insulin Secretion and Poor Insulin Sensitivity in Obese Children and Adolescents (2015)
- Pancreatic Fat is Associated with Metabolic Syndrome and Visceral Adipose Tissue but not Beta-Cell Function or Body Mass Index in Paediatric Obesity (2015)
- Dipeptidyl Peptidase-4 is Associated with Elevated Liver Enzymes, Impaired Glucose Tolerance and Lowered Glucagon-Like Peptide-1 in Obese Children (2015)
- Uppsala Longitudinal Study of Childhood Obesity (2014)
- Functional differences between aggregated and dispersed insulin-producing cells (2013)
- Signaling in Insulin-Secreting MIN6 Pseudoislets and Monolayer Cells (2013)
- FFAR1 is involved in both the acute and chronic effects of palmitate on insulin secretion (2013)
- FFAR1 Is Involved in Both the Acute and Chronic Effects of Palmitate on Insulin Secretion (2013)
- Free fatty acid determination in plasma by GC-MS after conversion to Weinreb amides (2013)
- Hög tid att söka till nya MD/PhD-programmet vid Uppsala universitet (2012)
- Lipotoxicity is glucose-dependent in INS-1E cells but not in human islets and MIN6 cells (2011)
- UPR in palmitate-treated pancreatic beta-cells is not affected by altering oxidation of the fatty acid (2011)
- Palmitate-induced changes in protein expression of insulin secreting INS-1E cells (2010)
- Pseudoislets as primary islet replacements for research Report on a symposium at King's College London, London UK (2010)
- Fatty acid-induced oxidation and triglyceride formation is higher in insulin-producing MIN6 cells exposed to oleate compared to palmitate (2010)
- Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing beta-cells (2010)
- Rapid alternations in DNA methylation patterns in insulin-producing beta cells correlate with changes in ambient glucose levels (2010)
- Islet protein profiling (2009)
- Short-term glucocorticoid treatment increases insulin secretion in islets derived from lean mice through multiple pathways and mechanisms (2009)
- Apoptotic, Regenerative, And Immune-Related Signaling in Human Islets from Type 2 Diabetes Individuals (2009)
- Role of MAPK in apolipoprotein CIII-induced apoptosis in INS-1E cells (2009)
- Proteins altered by elevated levels of palmitate or glucose implicated in impaired glucose-stimulated insulin secretion (2009)
- Glucose-induced de novo synthesis of fatty acyls causes proportional increases in INS-1E cellular lipids (2008)
- AMP-activated protein kinase agonist dose dependently improves function and reduces apoptosis in glucotoxic beta-cells without changing triglyceride levels (2008)
- Diazoxide-induced beta-cell rest reduces endoplasmic reticulum stress in lipotoxic beta-cells (2008)
- Glucolipotoxicity in INS-1E cells is counteracted by carnitine palmitoyltransferase 1 over-expression (2008)
- Serum protein patterns in newly diagnosed type 2 diabetes mellitus--influence of diabetic environment and family history of diabetes. (2008)
- Plasma proteome changes in subjects with Type 2 diabetes mellitus with a low or high early insulin response (2008)
- Evaluation of the SELDI-TOF MS technique for protein profiling of pancreatic islets exposed to glucose and oleate (2007)
- Oxo-4-methylpentanoic acid directs the metabolism of GABA into the Krebs cycle in rat pancreatic islets (2006)
- Mitochondrial protein patterns correlating with impaired insulin secretion from INS-1E cells exposed to elevated glucose concentrations (2006)
- Protein profiling of pancreatic islets (2006)
- Glucose-induced changes of multiple mouse islet proteins analysed by two-dimensional gel electrophoresis and mass spectrometry. (2005)
- Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry. (2005)
- Regulation of 11beta-hydroxysteroid dehydrogenase type 1 and glucose-stimulated insulin secretion in pancreatic islets of Langerhans. (2005)
- Regulation of 11beta-hydroxysterioid dehydrogenase type 1 and glucose-stimulated insulin secretion in pancreatic islets of Langerhans (2004)
- Phenotyping of individual pancreatic islets locates genetic defects instimulus secretion coupling to Niddm1i within the major diabetes locus inGK rats. (2001)
- Glucose-regulated pulsatile insulin release from mouse islets via the K(ATP) channel-independent pathway. (2001)
- Appearance of glucose-induced insulin release in fetal rat β-cells (1998)
- In vitro regulation of insulin release and biosynthesis of fetal rat pancreatic cells explanted on pregnancy day 16. (1997)
- Screening of inflammatory markers finds hepatocyte growth factor to be associated with weight gain in children and adolescents with obesity
- Effect of phthalate metabolite MEHHP on mitochondrial metabolism and dynamics in human endometrial stromal cells
- Role of mitochondrial metabolism and fission protein DRP-1 in palmitate-induced glucagon secretion
