Lars Gedda

Lyophilization of Curcumin-Loaded Lipodisks: pre-and post-processing evaluation of formulation characteristics

Ali, Sajid; Silva, Luís; Gedda, Lars; Eskner, Ebba et al.

Ingår i International Journal of Pharmaceutics, 2026

• DOI för Lyophilization of Curcumin-Loaded Lipodisks: pre-and post-processing evaluation of formulation characteristics
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Revealing the Morphology of Small Multilamellar Lipid Nanoparticles (SMLPs) made by In-Vial Homogenization

Akcesme, Sevda; Schmager, Stefanie; Al-Tikriti, Yassir; Gedda, Lars et al.

Ingår i European Journal of Pharmaceutical Sciences, 2026

• DOI för Revealing the Morphology of Small Multilamellar Lipid Nanoparticles (SMLPs) made by In-Vial Homogenization
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Spontaneous formation of small and ultrasmall unilamellar vesicles in mixtures of drug surfactant and phospholipid: Effect of chemical structure of phospholipid tails on vesicle size

Forooqi Motlaq, Vahid; Gedda, Lars; Edwards, Katarina; Doutch, James et al.

Ingår i Journal of Colloid and Interface Science, s. 1008-1018, 2025

• DOI för Spontaneous formation of small and ultrasmall unilamellar vesicles in mixtures of drug surfactant and phospholipid: Effect of chemical structure of phospholipid tails on vesicle size
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Development and in vitro evaluation of lipodisks optimized for co-delivery of chemotherapeutic drugs and membranolytic anticancer peptides

Silva, Luis; Ali, Sajid; Gedda, Lars; Agmo Hernández, Víctor et al.

Ingår i Journal of Colloid and Interface Science, 2025

• DOI för Development and in vitro evaluation of lipodisks optimized for co-delivery of chemotherapeutic drugs and membranolytic anticancer peptides
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Novel thermosensitive small multilamellar lipid nanoparticles with promising release characteristics made by dual centrifugation

Koehler, Jonas K.; Schmager, Stefanie; Schnur, Johannes; Gedda, Lars et al.

Ingår i European Journal of Pharmaceutical Sciences, 2025

• DOI för Novel thermosensitive small multilamellar lipid nanoparticles with promising release characteristics made by dual centrifugation
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Lyophilization of Curcumin-Loaded Lipodisks: pre-and post-processing evaluation of formulation characteristics

Ali, Sajid; Silva, Luís; Gedda, Lars; Eskner, Ebba et al.

Ingår i International Journal of Pharmaceutics, 2026

• DOI för Lyophilization of Curcumin-Loaded Lipodisks: pre-and post-processing evaluation of formulation characteristics
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Revealing the Morphology of Small Multilamellar Lipid Nanoparticles (SMLPs) made by In-Vial Homogenization

Akcesme, Sevda; Schmager, Stefanie; Al-Tikriti, Yassir; Gedda, Lars et al.

Ingår i European Journal of Pharmaceutical Sciences, 2026

• DOI för Revealing the Morphology of Small Multilamellar Lipid Nanoparticles (SMLPs) made by In-Vial Homogenization
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Spontaneous formation of small and ultrasmall unilamellar vesicles in mixtures of drug surfactant and phospholipid: Effect of chemical structure of phospholipid tails on vesicle size

Forooqi Motlaq, Vahid; Gedda, Lars; Edwards, Katarina; Doutch, James et al.

Ingår i Journal of Colloid and Interface Science, s. 1008-1018, 2025

• DOI för Spontaneous formation of small and ultrasmall unilamellar vesicles in mixtures of drug surfactant and phospholipid: Effect of chemical structure of phospholipid tails on vesicle size
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Development and in vitro evaluation of lipodisks optimized for co-delivery of chemotherapeutic drugs and membranolytic anticancer peptides

Silva, Luis; Ali, Sajid; Gedda, Lars; Agmo Hernández, Víctor et al.

Ingår i Journal of Colloid and Interface Science, 2025

• DOI för Development and in vitro evaluation of lipodisks optimized for co-delivery of chemotherapeutic drugs and membranolytic anticancer peptides
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Novel thermosensitive small multilamellar lipid nanoparticles with promising release characteristics made by dual centrifugation

Koehler, Jonas K.; Schmager, Stefanie; Schnur, Johannes; Gedda, Lars et al.

Ingår i European Journal of Pharmaceutical Sciences, 2025

• DOI för Novel thermosensitive small multilamellar lipid nanoparticles with promising release characteristics made by dual centrifugation
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Investigation of supramolecular structures in various aqueous solutions of an amyloid forming peptide using small-angle X-ray scattering

Brunzell, Ellen; Sigfridsson, Kalle; Gedda, Lars; Edwards, Katarina et al.

Ingår i Soft Matter, s. 2272-2279, 2024

• DOI för Investigation of supramolecular structures in various aqueous solutions of an amyloid forming peptide using small-angle X-ray scattering
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Dual centrifugation as a novel and efficient method for the preparation of lipodisks

Ali, Sajid; Koehler, Jonas K.; Silva, Luís; Gedda, Lars et al.

Ingår i International Journal of Pharmaceutics, 2024

• DOI för Dual centrifugation as a novel and efficient method for the preparation of lipodisks
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A closer look at calcium-induced interactions between phosphatidylserine-(PS) doped liposomes and the structural effects caused by inclusion of gangliosides or polyethylene glycol- (PEG) modified lipids

Grad, Philipp; Edwards, Katarina; Gedda, Lars; Agmo Hernández, Víctor

Ingår i Biochimica et Biophysica Acta - Biomembranes, 2024

• DOI för A closer look at calcium-induced interactions between phosphatidylserine-(PS) doped liposomes and the structural effects caused by inclusion of gangliosides or polyethylene glycol- (PEG) modified lipids
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Spontaneous Formation of Ultrasmall Unilamellar Vesicles in Mixtures of an Amphiphilic Drug and a Phospholipid

Forooqi Motlaq, Vahid; Gedda, Lars; Edwards, Katarina; Doutch, James et al.

Ingår i Langmuir, s. 11337-11344, 2023

• DOI för Spontaneous Formation of Ultrasmall Unilamellar Vesicles in Mixtures of an Amphiphilic Drug and a Phospholipid
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Excited-state and charge-carrier dynamics in binary conjugated polymer dots towards efficient photocatalytic hydrogen evolution

Liu, Aijie; Wang, Sicong; Song, Hongwei; Liu, Yawen et al.

Ingår i Physical Chemistry, Chemical Physics - PCCP, s. 2935-2945, 2023

• DOI för Excited-state and charge-carrier dynamics in binary conjugated polymer dots towards efficient photocatalytic hydrogen evolution
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Tailoring the Lamellarity of Liposomes Prepared by Dual Centrifugation

Koehler, Jonas K. K.; Gedda, Lars; Wurster, Leonie; Schnur, Johannes et al.

Ingår i Pharmaceutics, 2023

• DOI för Tailoring the Lamellarity of Liposomes Prepared by Dual Centrifugation
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Vesicle-enriched secretomes alter bacterial competitive abilities and are drivers of evolution in microbial communities

Warsi, Omar M.; Gedda, Lars; Edwards, Katarina; Andersson, Dan I.

Ingår i FEMS Microbiology Ecology, 2023

• DOI för Vesicle-enriched secretomes alter bacterial competitive abilities and are drivers of evolution in microbial communities
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Structural Characterization Study of a Lipid Nanocapsule Formulation Intended for Drug Delivery Applications Using Small-Angle Scattering Techniques

Urimi, Dileep; Hellsing, Maja; Mahmoudi, Najet; Soderberg, Christopher et al.

Ingår i Molecular Pharmaceutics, s. 1068-1077, 2022

• DOI för Structural Characterization Study of a Lipid Nanocapsule Formulation Intended for Drug Delivery Applications Using Small-Angle Scattering Techniques
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Polymer Dots as Photoactive Membrane Vesicles for [FeFe]-Hydrogenase Self-Assembly and Solar-Driven Hydrogen Evolution

Pavliuk, Mariia V.; Lorenzi, Marco; Morado, Dustin R.; Gedda, Lars et al.

Ingår i Journal of the American Chemical Society, s. 13600-13611, 2022

• DOI för Polymer Dots as Photoactive Membrane Vesicles for [FeFe]-Hydrogenase Self-Assembly and Solar-Driven Hydrogen Evolution
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Influence of Chain Length of Gradient and Block Copoly(2-oxazoline)s on Self-Assembly and Drug Encapsulation

Sedlacek, Ondrej; Bardoula, Valentin; Vuorimaa-Laukkanen, Elina; Gedda, Lars et al.

Ingår i Small, 2022

• DOI för Influence of Chain Length of Gradient and Block Copoly(2-oxazoline)s on Self-Assembly and Drug Encapsulation

Investigation of the enhanced ability of bile salt surfactants to solubilize phospholipid bilayers and form mixed micelles.

Forooqi Motlaq, Vahid; Ortega-Holmberg, Mattias; Edwards, Katarina; Gedda, Lars et al.

Ingår i Soft Matter, s. 7769-7780, 2021

• DOI för Investigation of the enhanced ability of bile salt surfactants to solubilize phospholipid bilayers and form mixed micelles.

Formulation development and upscaling of lipid nanocapsules as a drug delivery system for a novel cyclic GMP analogue intended for retinal drug delivery

Urimi, Dileep; Widenbring, Ronja; Garcia, Raul Oswaldo Perez; Gedda, Lars et al.

Ingår i International Journal of Pharmaceutics, s. 120640, 2021

• DOI för Formulation development and upscaling of lipid nanocapsules as a drug delivery system for a novel cyclic GMP analogue intended for retinal drug delivery
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Panchromatic Ternary Polymer Dots Involving Sub-Picosecond Energy and Charge Transfer for Efficient and Stable Photocatalytic Hydrogen Evolution

Liu, Aijie; Gedda, Lars; Axelsson, Martin; Pavliuk, Mariia et al.

Ingår i Journal of the American Chemical Society, s. 2875-2885, 2021

• DOI för Panchromatic Ternary Polymer Dots Involving Sub-Picosecond Energy and Charge Transfer for Efficient and Stable Photocatalytic Hydrogen Evolution
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Effect of gangliosides on structure and integrity of polyethylene glycol(PEG)-stabilized liposomes

Grad, Philipp; Gedda, Lars; Edwards, Katarina

Ingår i Journal of Colloid and Interface Science, s. 281-289, 2020

• DOI för Effect of gangliosides on structure and integrity of polyethylene glycol(PEG)-stabilized liposomes
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Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks

Lundsten, Sara; Hernandez, Victor Agmo; Gedda, Lars; Sarén, Tina et al.

Ingår i Nanomaterials, 2020

• DOI för Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks
• Ladda ner fulltext (pdf) av Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks

Osmoprotective effect of ubiquinone in lipid vesicles modelling the E. coli plasma membrane

Eriksson, Emma K.; Edwards, Katarina; Grad, Philipp; Gedda, Lars et al.

Ingår i Biochimica et Biophysica Acta - Biomembranes, s. 1388-1396, 2019

• DOI för Osmoprotective effect of ubiquinone in lipid vesicles modelling the E. coli plasma membrane
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EGF-targeting lipodisks for specific delivery of poorly water-soluble anticancer agents to tumour cells

Ahlgren, Sara; Fondell, Amelie; Gedda, Lars; Edwards, Katarina

Ingår i RSC Advances, s. 22178-22186, 2017

• DOI för EGF-targeting lipodisks for specific delivery of poorly water-soluble anticancer agents to tumour cells
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17AAG-induced internalisation of HER2- specific Affibody molecules

Göstring, Lovisa; Lindegren, Sture; Gedda, Lars

Ingår i Oncology Reports, s. 2574-2580, 2016

• DOI för 17AAG-induced internalisation of HER2- specific Affibody molecules

Pre-incubation of chemically crosslinked hyaluronan-based hydrogels, loaded with BMP-2 and hydroxyapatite, and its effect on ectopic bone formation

Stenfelt, Sonya; Hulsart-Billström, Gry; Gedda, Lars; Bergman, Kristoffer et al.

Ingår i Journal of materials science. Materials in medicine, s. 1013-1023, 2014

• DOI för Pre-incubation of chemically crosslinked hyaluronan-based hydrogels, loaded with BMP-2 and hydroxyapatite, and its effect on ectopic bone formation

Characterization of recombinant human bone morphogenetic protein-2 delivery from injectable hyaluronan-based hydrogels by means of I-125-radiolabelling

Piskounova, Sonya; Gedda, Lars; Hulsart-Billström, Gry; Hilborn, Jöns et al.

Ingår i Journal of Tissue Engineering and Regenerative Medicine, s. 821-830, 2014

• DOI för Characterization of recombinant human bone morphogenetic protein-2 delivery from injectable hyaluronan-based hydrogels by means of I-125-radiolabelling

Evaluation of Real-Time Immunohistochemistry and Interaction Map as an Alternative Objective Assessment of HER2 Expression in Human Breast Cancer Tissue

Gedda, Lars; Björkelund, Hanna; Lebel, Lena; Asplund, Anna et al.

Ingår i Applied immunohistochemistry & molecular morphology (Print), s. 497-505, 2013

• DOI för Evaluation of Real-Time Immunohistochemistry and Interaction Map as an Alternative Objective Assessment of HER2 Expression in Human Breast Cancer Tissue

Morphological differences in BMP-2-induced ectopic bone between solid and crushed hyaluronan hydrogel templates

Hulsart-Billström, Gry; Piskounova, Sonya; Gedda, Lars; Andersson, Britt-Marie et al.

Ingår i Journal of materials science. Materials in medicine, s. 1201-1209, 2013

• DOI för Morphological differences in BMP-2-induced ectopic bone between solid and crushed hyaluronan hydrogel templates

Resolving the EGF-EGFR interaction characteristics through a multiple-temperature, multiple-inhibitor, real-time interaction analysis approach

Björkelund, Hanna; Gedda, Lars; Malmqvist, Magnus; Andersson, Karl

Ingår i Molecular and Clinical Oncology, s. 343-352, 2013

• DOI för Resolving the EGF-EGFR interaction characteristics through a multiple-temperature, multiple-inhibitor, real-time interaction analysis approach

Generation and Evaluation of Bispecific Affibody Molecules for Simultaneous Targeting of EGFR and HER2

Ekerljung, Lina; Wållberg, Helena; Sohrabian, Azita; Andersson, Karl et al.

Ingår i Bioconjugate chemistry, s. 1802-1811, 2012

• DOI för Generation and Evaluation of Bispecific Affibody Molecules for Simultaneous Targeting of EGFR and HER2

The HER2-binding Affibody Molecule (Z_HER2:342)₂ Increases Radiosensitivity in SKBR-3 cells

Ekerljung, Lina; Lennartsson, Johan; Gedda, Lars

Ingår i PLOS ONE, 2012

• DOI för The HER2-binding Affibody Molecule (Z_HER2:342)₂ Increases Radiosensitivity in SKBR-3 cells
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Cellular effects of HER3-specific affibody molecules

Göstring, Lovisa; Malm, Magdalena; Höidén-Guthenberg, Ingmarie; Frejd, Fredrik et al.

Ingår i PLOS ONE, 2012

• DOI för Cellular effects of HER3-specific affibody molecules
• Ladda ner fulltext (pdf) av Cellular effects of HER3-specific affibody molecules

Improved bone formation by altering surface area of hyaluronan-based hydrogel carrier for bone morphogenetic protein-2

Billström, Gry Hulsart; Piskounova, Sonya; Gedda, Lars; Hilborn, Jöns et al.

Ingår i Bone, 2012

• DOI för Improved bone formation by altering surface area of hyaluronan-based hydrogel carrier for bone morphogenetic protein-2

The importance of proper protein handling and detection for the design of a BMP-2 release system

Piskounova, Sonya; Gedda, Lars; Hulsart Billström, Gry; Hilborn, Jöns et al.

Ingår i Journal of Tissue Engineering and Regenerative Medicine, s. 322-322, 2012

• DOI för The importance of proper protein handling and detection for the design of a BMP-2 release system

Experimental radionuclide therapy of HER2-expressing xenografts using two-step targeting Nuclisome-particles

Gedda, Lars; Fondell, Amelie; Lundqvist, Hans; Park, John et al.

Ingår i Journal of Nuclear Medicine, s. 480-487, 2012

• DOI för Experimental radionuclide therapy of HER2-expressing xenografts using two-step targeting Nuclisome-particles

Nuclisome: targeting the tumor cell nucleus

Gedda, Lars; Edwards, Katarina

Ingår i Tumor Biology, s. 661-667, 2012

• DOI för Nuclisome: targeting the tumor cell nucleus
• Ladda ner fulltext (pdf) av Nuclisome: targeting the tumor cell nucleus

Combining phage and staphylococcal surface display for generation of ErbB3-specific Affibody molecules

Kronqvist, Nina; Malm, Magdalena; Göstring, Lovisa; Gunneriusson, Elin et al.

Ingår i Protein Engineering Design & Selection, s. 385-396, 2011

• DOI för Combining phage and staphylococcal surface display for generation of ErbB3-specific Affibody molecules

Avoiding false negative results in specificity analysis of protein-protein interactions

Björkelund, Hanna; Gedda, Lars; Andersson, Karl

Ingår i Journal of Molecular Recognition, s. 81-89, 2011

• DOI för Avoiding false negative results in specificity analysis of protein-protein interactions

Gefitinib Induces Epidermal Growth Factor Receptor Dimers Which Alters the Interaction Characteristics with (125)I-EGF

Björkelund, Hanna; Gedda, Lars; Barta, Pavel; Malmqvist, Magnus et al.

Ingår i PLOS ONE, 2011

• DOI för Gefitinib Induces Epidermal Growth Factor Receptor Dimers Which Alters the Interaction Characteristics with (125)I-EGF

Comparing the epidermal growth factor interaction with four different cell lines: intriguing effects imply strong dependency of cellular context

Björkelund, Hanna; Gedda, Lars; Andersson, Karl

Ingår i PLoS ONE, 2011

• DOI för Comparing the epidermal growth factor interaction with four different cell lines: intriguing effects imply strong dependency of cellular context

In vitro evaluation and biodistribution of HER2-targeted liposomes loaded with an 125I-labelled DNA-intercalator

Fondell, Amelie; Edwards, Katarina; Unga, Johan; Kullberg, Erika et al.

Ingår i Journal of drug targeting (Print), s. 846-855, 2011

• DOI för In vitro evaluation and biodistribution of HER2-targeted liposomes loaded with an 125I-labelled DNA-intercalator

Oncolytic adenovirus modified with somatostatin motifs for selective infection of neuroendocrine tumor cells

Leja, Justyna; Yu, Di; Nilsson, Berith; Gedda, Lars et al.

Ingår i Gene Therapy, s. 1052-1062, 2011

• DOI för Oncolytic adenovirus modified with somatostatin motifs for selective infection of neuroendocrine tumor cells

Nuclisome: a novel concept for radionuclide therapy using targeting liposomes

Fondell, Amelie; Edwards, Katarina; Ickenstein, Ludger M; Sjöberg, Stefan et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 114-123, 2010

• DOI för Nuclisome: a novel concept for radionuclide therapy using targeting liposomes

Blocking EGFR in the liver improves the tumor-to-liver uptake ratio of radiolabeled EGF

Kareem, Heewa; Sandström, Karl; Elia, Ronny; Gedda, Lars et al.

Ingår i Tumor Biology, s. 79-87, 2010

• DOI för Blocking EGFR in the liver improves the tumor-to-liver uptake ratio of radiolabeled EGF

Real-time immunohistochemistry analysis of embedded tissue

Gedda, Lars; Björkelund, Hanna; Andersson, Karl

Ingår i Applied Radiation and Isotopes, s. 2372-2376, 2010

• DOI för Real-time immunohistochemistry analysis of embedded tissue

Engineering and characterization of a bispecific HER2 x EGFR-binding affibody molecule

Friedman, Mikaela; Lindstrom, Sara; Ekerljung, Lina; Andersson-Svahn, Helene et al.

Ingår i Biotechnology and applied biochemistry, s. 121-131, 2009

• DOI för Engineering and characterization of a bispecific HER2 x EGFR-binding affibody molecule

Hsp90 is expressed and represents a therapeutic target in human oesophageal cancer using the inhibitor 17-allylamino-17-demethoxygeldanamycin

Wu, Xuping; Wanders, Alkwin; Wardega, Piotr; Tinge, B. et al.

Ingår i British Journal of Cancer, s. 334-343, 2009

• DOI för Hsp90 is expressed and represents a therapeutic target in human oesophageal cancer using the inhibitor 17-allylamino-17-demethoxygeldanamycin

Flow cytometric in situ proximity ligation analyses of protein interactions and post-translational modification of the epidermal growth factor receptor family

Leuchowius, Karl-Johan; Weibrecht, Irene; Landegren, Ulf; Gedda, Lars et al.

Ingår i Cytometry: Part A, s. 833-839, 2009

• DOI för Flow cytometric in situ proximity ligation analyses of protein interactions and post-translational modification of the epidermal growth factor receptor family

Dimeric HER2-specific affibody molecules inhibit proliferation of the SKBR-3 breast cancer cell line

Ekerljung, Lina; Lindborg, Malin; Gedda, Lars; Frejd, Fredrik Y. et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 489-494, 2008

• DOI för Dimeric HER2-specific affibody molecules inhibit proliferation of the SKBR-3 breast cancer cell line

Targeting EGFR and HER2 with 211At-labeled molecules: unexpected and expected dose-effect relations in cultured tumor cells

Carlsson, Jörgen; Steffen, Ann-Charlott; Sundberg, Åsa L.; Vikström, Mikael et al.

Ingår i Current radiopharmaceuticals, s. 225-233, 2008

[Lu-177]pertuzumab: Experimental therapy of HER-2-expressing xenografts

Persson, Mikael; Gedda, Lars; Lundqvist, Hans; Tolmachev, Vladimir et al.

Ingår i Cancer Research, s. 326-331, 2007

• DOI för [Lu-177]pertuzumab: Experimental therapy of HER-2-expressing xenografts

In vitro evaluation of two polyhedral boron anion derivatives as linkers for attachment of radioiodine to the anti-HER2 monoclonal antibody trastuzumab

Persson, Mikael; Sivaev, Igor; Winberg, Karl-Johan; Gedda, Lars et al.

Ingår i Cancer Biotherapy and Radiopharmaceuticals, s. 585-596, 2007

• DOI för In vitro evaluation of two polyhedral boron anion derivatives as linkers for attachment of radioiodine to the anti-HER2 monoclonal antibody trastuzumab

Penetration of tumor therapy interesting substances in non-vascularized metastases.: Review of studies in multicellular spheroids

Carlsson, Jörgen; Gedda, Lars

Ingår i Current Cancer Therapy Reviews, s. 293-304, 2006

• DOI för Penetration of tumor therapy interesting substances in non-vascularized metastases.: Review of studies in multicellular spheroids

Planning for intracavitary anti-EGFR radionuclide therapy of gliomas: Literature review and data on EGFR expression

Carlsson, Jörgen; Ren, Z. P.; Wester, K.; Sundberg, A. L. et al.

Ingår i Journal of Neuro-Oncology, s. 33-45, 2006

• DOI för Planning for intracavitary anti-EGFR radionuclide therapy of gliomas: Literature review and data on EGFR expression

A novel I-125-labeled daunorubicin derivative for radionuclide-based cancer therapy

Ickenstein, Ludger M.; Edwards, Katarina; Sjöberg, Stefan; Carlsson, Jörgen et al.

Ingår i Nuclear Medicine and Biology, s. 773-783, 2006

• DOI för A novel I-125-labeled daunorubicin derivative for radionuclide-based cancer therapy

Astatinated trastuzumab, a putative agent for radionuclide immunotherapy of ErbB2-expressing tumours

Persson, Mikael I.; Gedda, Lars; Jensen, H. J.; Lundqvist, Hans et al.

Ingår i Oncology Reports, s. 673-80, 2006

111In-benzyl-DTPA-ZHER2:342, an affibody-based conjugate for in vivo imaging of HER2 expression in malignant tumors

Tolmachev, Vladimir; Nilsson, Fredrik Y.; Widström, Charles; Andersson, Karl et al.

Ingår i Journal of Nuclear Medicine, s. 846-53, 2006

Penetration of tumor therapy interesting substances in non-vascularized metastases; Review of studies in cellular spheroids

Carlsson, Jörgen; Gedda, Lars

Ingår i Current Cancer Therapy Reviews, s. 293-304, 2006

An aminoacridine derivative for radionuclide therapy: DNA binding properties studied in a novel cell-free in vitro assay

Kullberg, Erika Bohl; Stenerlöw, Bo; Ghirmai, Senait; Lundqvist, Hans et al.

Ingår i International Journal of Oncology, s. 1355-60, 2005

[(177)Lu]pertuzumab: experimental studies on targeting of HER-2 positive tumour cells

Persson, Mikael; Tolmachev, Vladimir; Andersson, Karl; Gedda, Lars et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 1457-62, 2005

• DOI för [(177)Lu]pertuzumab: experimental studies on targeting of HER-2 positive tumour cells

An Aminoacridine Derivative for Radionuclide Therapy: Dna-Binding Properties Studied in a Novel Cell-Free in vitro Assay

Kullberg, E-B.; Stenerlöw, B.; Ghirmait, Senait; Lundqvist, Hans et al.

Ingår i Int. J. Onc., s. 1355-1360, 2005

EGF-receptor targeted liposomes with boronated acridine: growth inhibition of cultured glioma cells after neutron irradiation

Kullberg, Erika Bohl; Wei, Qichun; Capala, Jacek; Giusti, Valerio et al.

Ingår i International Journal of Radiation Biology, s. 621-629, 2005

• DOI för EGF-receptor targeted liposomes with boronated acridine: growth inhibition of cultured glioma cells after neutron irradiation

Identification and characterization of a novel splicing variant of vesicular monoamine transporter 1

Essand, Magnus; Vikman, Sofia; Grawé, Jan; Gedda, Lars et al.

Ingår i Journal of Molecular Endocrinology, s. 489-501, 2005

• DOI för Identification and characterization of a novel splicing variant of vesicular monoamine transporter 1

Radionuklidterapi - möjlig väg mot bättre behandling av cancer: Hindret är bristen på kommersiellt tillgängliga nuklider i kliniken

Lundqvist, Hans; Carlsson, Jörgen; Gedda, Lars; Tolmachev, Vladimir et al.

Ingår i Läkartidningen, s. 1000-1006, 2004

[177Lu]Bz-DTPA-EGF: Preclinical characterization of a potential radionuclide targeting agent against glioma

Sundberg, Åsa Liljegren; Gedda, Lars; Orlova, Anna; Bruskin, Alexander et al.

Ingår i Cancer Biotherapy and Radiopharmaceuticals, s. 195-204, 2004

• DOI för [177Lu]Bz-DTPA-EGF: Preclinical characterization of a potential radionuclide targeting agent against glioma

Comparative biodistribution of potential anti-glioblastoma conjugates [111In]DTPA-hEGF and [111In]Bz-DTPA-hEGF in normal mice

Tolmachev, Vladimir; Orlova, Anna; Wei, Qichun; Bruskin, Alexander et al.

Ingår i Cancer Biotherapy and Radiopharmaceuticals, s. 491-501, 2004

• DOI för Comparative biodistribution of potential anti-glioblastoma conjugates [111In]DTPA-hEGF and [111In]Bz-DTPA-hEGF in normal mice

Introductory experiments on ligand liposomes as delivery agents for boronneutron capture therapy

Bohl Kullberg, E; Carlsson, Jörgen; Edwards, Katarina; Capala, J et al.

Ingår i International Journal of Oncology, s. 461-467, 2003

Trastuzumab-conjugated boron-containing liposomes for tumor-celltargeting; development and cellular studies.

Wei, Q; Kullberg, EB; Gedda, L

Ingår i Int J Oncol, s. 1159, 2003

[111In]Bz-DTPA-hEGF: Preparation and in vitro characterization of a potential anti-glioblastoma targeting agent

Sundberg, Åsa Liljegren; Orlova, Anna; Bruskin, Alexander; Gedda, Lars et al.

Ingår i Cancer Biotherapy and Radiopharmaceuticals, s. 643-54, 2003

• DOI för [111In]Bz-DTPA-hEGF: Preparation and in vitro characterization of a potential anti-glioblastoma targeting agent

Ligand liposomes and boron neutron capture therapy

Carlsson, Jörgen; Bohl Kullberg, Erika; Capala, Jacek; Sjöberg, Stefan et al.

Ingår i Journal of Neuro-Oncology, s. 47, 2003

Combined effect of gefitinib ('Iressa', ZD1839) and targeted radiotherapy with 211At-EGF

Sundberg, Åsa Liljegren; Almqvist, Ylva; Orlova, Anna; Blomquist, Erik et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 1348-56, 2003

• DOI för Combined effect of gefitinib ('Iressa', ZD1839) and targeted radiotherapy with 211At-EGF

Cellular retention of radioactivity and increased radiation dose: Modelexperiments with EGF-dextran

Sundberg, Åsa Liljegren; Blomquist, Erik; Carlsson, Jörgen; Steffen, Ann-Chalott et al.

Ingår i Nuclear Medicine and Biology, s. 303-315, 2003

• DOI för Cellular retention of radioactivity and increased radiation dose: Modelexperiments with EGF-dextran

Tumor-cell targeted EGF liposomes loaded with boronated acridine: Uptake and processing

Kullberg, Erika Bohl; Nestor, Marika; Gedda, Lars

Ingår i Pharmaceutical research, s. 229-236, 2003

• DOI för Tumor-cell targeted EGF liposomes loaded with boronated acridine: Uptake and processing

Development of EGF-conjugated liposomes for targeted delivery of boronated DNA-binding agents

Bohl Kullberg, Erika; Bergstrand, Nill; Carlsson, Jörgen; Edwards, Katarina et al.

Ingår i Bioconjugate chemistry, s. 737-743, 2002

• DOI för Development of EGF-conjugated liposomes for targeted delivery of boronated DNA-binding agents

Comparative biodistribution of the radiohalogenated (Br, I and At) antibody A33: Implications for in vivo dosimetry

Orlova, Anna; Höglund, Johanna; Lubberink, Mark; Lebeda, Ondrej et al.

Ingår i Cancer Biotherapy and Radiopharmaceuticals, s. 385-96, 2002

• DOI för Comparative biodistribution of the radiohalogenated (Br, I and At) antibody A33: Implications for in vivo dosimetry

Internalisation and retention of EGF-dextran associated radioactivity intransfected Chinese hamster ovary cells expressing the human EGF-receptor.

Olsson, P; Collins, VP; Liu, L; Gedda, L et al.

Ingår i Int J Oncol, s. 1057, 2002

A new antibody recognizing the vIII mutation of human epidermal growthfactor receptor.

Ohman, L; Gedda, L; Hesselager, G; Larsson, R et al.

Ingår i Tumour Biol, s. 61, 2002

Effects of dextranation on the uptake of peptides in micrometastases:studies on binding of EGF in tumor spheroids.

Nilsson, P; Gedda, L; Sjostrom, A; Carlsson, J

Ingår i Tumour Biol, s. 229, 2001

Cellular processing of (125)I- and (111)in-labeled epidermal growth factor(EGF) bound to cultured A431 tumor cells

Orlova, Anna; Bruskin, Alexander; Sjöström, Anna; Lundqvist, Hans et al.

Ingår i Nuclear Medicine and Biology, s. 827-35, 2000

• DOI för Cellular processing of (125)I- and (111)in-labeled epidermal growth factor(EGF) bound to cultured A431 tumor cells

The influence of lipophilicity on binding of boronated DNA-intercalating compounds in human glioma speroids

Gedda, L; Ghaneolhosseini, H; Nilsson, P; Nyholm, K et al.

Ingår i Anti-Cancer Drug Design, s. 277-286, 2000

The influence of lipophilicity on binding of boronated DNA-intercalatingcompounds in human glioma spheroids.

Gedda, L; Ghaneolhosseini, H; Nilsson, P; Nyholm, K et al.

Ingår i Anti-Cancer Drug Des., s. 277, 2000

Closo-dodecaborate(2-) as a linker for iodination of macromolecules: Aspects on conjugation chemistry and biodistribution

Tolmachev, Vladimir; Koziorowski, Jacek; Sivaev, Igor; Lundqvist, Hans et al.

Ingår i Bioconjugate chemistry, s. 338-45, 1999

• DOI för Closo-dodecaborate(2-) as a linker for iodination of macromolecules: Aspects on conjugation chemistry and biodistribution

Conjugate chemistry and cellular processing of EGF-dextran

Carlsson, Jörgen; Blomquist, Erik; Gedda, Lars; Liljegren, Åsa et al.

Ingår i Acta Oncologica, s. 313-321, 1999

Conjugate chemistry, iodination and cellular binding of mEGF-dextran-tyrosine: preclinical tests in preparation for clinicaltrials

Zhao, Q; Blomquist, E; Bolander, H; Gedda, Lars et al.

Ingår i International Journal of Molecular Medicine, s. 693-702, 1998

Cytotoxicity and subcellular localization of boronated phenanthridinium analogues.

Gedda, L; Silvander, M; Sjoberg, S; Tjarks, W et al.

Ingår i Anti-Cancer Drug Des., s. 671, 1998

Uptake of a boronated epidermal growth factor-dextran conjugate in CHOtor expression.

Olsson, P; Gedda, L; Goike, H; Liu, L et al.

Ingår i Anti-Cancer Drug Des., s. 279, 1998

Chemistry and biology of some low molecular weight boron compounds forboron neutron capture therapy.

Sjoberg, S; Carlsson, J; Ghaneolhosseini, H; Gedda, L et al.

Ingår i J Neurooncol, s. 41, 1997

Labelling of boron containing compounds with halogen isotopes

Tolmachev, Vladimir; Lundqvist, Hans; Sivaev, Igor; Orlova, Anna et al.

Ingår i Journal of labelled compounds & radiopharmaceuticals, s. 122, 1997

Epidermal growth factor-DNA conjugate for two-step targeting: development and introductory in vitro evaluation.

Gedda, L; Carlsson, J

Ingår i Int J Oncology, s. 789, 1997

Development and in vitro studies of epidermal growth factor-dextranconjugates for boron neutron capture therapy.

Gedda, L; Olsson, P; Ponten, J; Carlsson, J

Ingår i Bioconjug Chem, s. 584, 1996

Strategy for boron neutron capture therapy against tumor cells with over-expression of the epidermal growth factor-receptor.

Carlsson, J; Gedda, L; Grönvik, C; Hartman, T et al.

Ingår i International Journal of Radiation Oncology, Biology, Physics, s. 105-15, 1994

Synthesis, radioiodination, DNA binding and cellular uptake of some doxorubicin analogues

Winander, Cecilia; Gedda, Lars; Tolmachev, Vladimir; Sjöberg, Stefan

Bororn neutron capture therapy. Preclinical studies of compounds for tumour targeting.

Gedda, L

Uppsala University, 1997

The Auger effect in molecular targeting therapy.

Lundqvist, Hans; Stenerlöw, Bo; Gedda, Lars

Ingår i Targeted radionuclide tumor therapy., s. 195-214, Springer, 2008

• DOI för The Auger effect in molecular targeting therapy.

SLT-particles for two step targeting in boron neutron capture therapy

Bohl, E.; Carlsson, J.; Edwards, K.; Sjöberg, S. et al.

Ingår i Frontiers in Neutron Capture Therapy, Kluwer Academic/Plenum Publishers, New York, 2001

Stabilised Liposomes with Double Targeting for Use in BNCT

Bergstrand, Nill; Bohl, Erika; Carlsson, Jörgen; Edwards, Katarina et al.

Ingår i Contemporary Boron Chemistry, s. 131-134, Royal Society of Chemistry, 2000

• DOI för Stabilised Liposomes with Double Targeting for Use in BNCT

Boron neutron capture therapy against tumor cells with overexpression of the EGF-receptor

Carlsson, Jörgen; Gedda, Lars; Grönvik, C; Hartman, T et al.

Ingår i Cancer Neutron Capture Therapy, s. 49-56, Plenum Press, 1996

Preparation of epidermal growth factor conjugates aimed for boron neutron capture therapy.

Gedda, L; Olsson, P; Carlsson, J

Ingår i Cancer Neutron Capture Therapy for Cancer, s. 37, Mishima Y, Plenum Press, New York, 1996

Synthesis and initial biological evaluation of carborane-containing phenanthridinium derivatives.

Tjarks, W; Malmquist, J; Gedda, L; Sjoberg, S et al.

Ingår i Cancer Neutron Capture Therapy for Cancer, s. 121, Mishima Y, Plenum Press, New York, 1996

Preclinical research on Auger therapy

Lundqvist, H; Bohl, E; Carlsson, J; Gedda, L et al.

2003

SLT-particles for two-step targeting in boron neutron capture therapy

Gedda, Lars; Bohl, E; Edwards, Katarina; Sjöberg, S et al.

Ingår i Frontiers in Neutron Capture Therapy, Volume 1, s. 70, 2001

Cellular spheroids as a micrometastasis model in preclinical tests of boron neutron capture therapy

Carlsson, J; Bohl, E; Edwards, Katarina; Nilsson, P et al.

Ingår i Frontiers in Neutron Capture Therapy, volume 1, s. 109, 2001

Stabilised liposomes with double targeting intendent for use in BNCT

Carlsson, Jörgen; Edwards, Katarina; Ghaneolhosseini, H; Gedda, Lars et al.

Ingår i Frontiers in Neutron Capture Therapy, s. 184, 2001

Carboranyl phenantridinium analogues: Synthesis and biological evaluation.

Tjarks, W; Gedda, L; Silvander, M; Mars, U et al.

1997

Two step targeting: EGF-conjugate for delivery of DNA-binding compounds.

Gedda, L; Silvander, M; Sjoberg, S; Tjarks, W et al.

1997

In vitro and in vivo studies of a boronated epidermal growth factor (EGF)-dextran conjugate.

Olsson, P; Gedda, L; Goike, H; Liu, L et al.

1997

Influence of liposome composition on cellular drug delivery and therapeutic effect mediated by Nuclisome-particles

Fondell, Amelie; Edwards, Katarina; Gustafsson, Erika; Park, John et al.

Improved bone formation through increased surface area of hyaluronan-based hydrogels when used as carriers for BMP-2

Hulsart-Billström, Gry; Piskounova, Sonya; Gedda, Lars; Hilborn, Jöns et al.

[111In] benzyl-DTPA-EGF, a new potential radiopeptide for targeting of glioma

Orlova, Anna; Sundberg, Å.; Bruskin, Alexander; Gedda, Lars et al.

Ingår i European Journal of Nuclear Medicine, 2002

[111In]-DTPA-hEGF and [111In]-Bz-DTPA-hEGF: preparation and in vitro studies of two anti- glioblastoma conjugates with residualising labels

Liljegren Sundberg, Åsa; Orlova, Anna; Bruskin, Alexander; Gedda, Lars et al.

Ingår i Cancer Biotherapy and Radiopharmaceuticals, s. 354-354, 2002

Cellular processing of iodinated and astatinated trastuzumab in cultured SK-BR-3 breast cancer cells

Persson, Mikael; Orlova, Anna; Gedda, Lars; Carlsson, Jörgen et al.

Ingår i Cancer Biotherapy and Radiopharmaceuticals, s. 353-354, 2002

Synthesis of [211At] N-[8-(acridin-9-ylamino)-octyl]-3- astatobenzamide, an astatinated DNA intercalator

Orlova, Anna; Bohl, E.; Ghaneolhosseino, H.; Gedda, Lars et al.

Ingår i European Journal of Nuclear Medicine, s. 317, 2000

Cellular processing of ¹²⁵I- and ¹¹¹in-labeled epidermal growth factor (EGF) bound to cultured A431 tumor cells

Orlova, Anna; Bruskin, Alexander; Sjöström, Anna; Lundqvist, Hans et al.

Ingår i Nuclear Medicine and Biology, s. 827-835, 2000

• DOI för Cellular processing of ¹²⁵I- and ¹¹¹in-labeled epidermal growth factor (EGF) bound to cultured A431 tumor cells

Penetration and Binding of EGF-Dextran Conjugates in Cultured-Cell Spheroids

Nilsson, Per; Gedda, Lars; Sjöstrom, Anna; Zhao, Qinghai et al.

Ingår i European Journal of Cell Biology, s. 118-118, 1997

Two-step targeting: EGF-based conjugate for deliverance of nucleus-specific boron compounds.

Gedda, L; Silvander, M; Sjoberg, S; Tjarks, W et al.

Ingår i Seventh International Symposium on Neutron Capture Therapy for Cancer, s. 67, 1996

In vitro and in vivo studies of a boronated epidermal growth factor (EGF)-dextran conjugate

Olsson, P; Gedda, L; Goike, H; Liu, L et al.

Ingår i Seventh International Symposium on Neutron Capture Therapy for Cancer, s. 145, 1996

Carboranyl phenanthridinium analogues: synthesis and biological evaluation.

Tjarks, W; Ghaneolhosseini, H; Gedda, L; Mars, U et al.

Ingår i Seventh International Symposium on Neutron Capture Therapy for Cancer, s. 74, 1996