Sherry Mowbray
Professor vid Institutionen för cell- och molekylärbiologi; Strukturbiologi
- Telefon:
- 018-471 49 90
- E-post:
- sherry.mowbray@icm.uu.se
- Besöksadress:
- Husargatan 3
752 37 Uppsala - Postadress:
- Box 596
75124 Uppsala
Publikationer
Senaste publikationer
Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2024
- DOI för Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria
- Ladda ner fulltext (pdf) av Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria
Ingår i Bioorganic & Medicinal Chemistry Letters, 2024
Ingår i European Journal of Medicinal Chemistry, 2024
- DOI för Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors
- Ladda ner fulltext (pdf) av Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors
Bacterial type I signal peptidase inhibitors-Optimized hits from nature
Ingår i European Journal of Medicinal Chemistry, 2022
Ingår i ACS - Infectious Diseases, s. 482-498, 2022
- DOI för Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)
- Ladda ner fulltext (pdf) av Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)
Alla publikationer
Artiklar i tidskrift
Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2024
- DOI för Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria
- Ladda ner fulltext (pdf) av Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria
Ingår i Bioorganic & Medicinal Chemistry Letters, 2024
Ingår i European Journal of Medicinal Chemistry, 2024
- DOI för Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors
- Ladda ner fulltext (pdf) av Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors
Bacterial type I signal peptidase inhibitors-Optimized hits from nature
Ingår i European Journal of Medicinal Chemistry, 2022
Ingår i ACS - Infectious Diseases, s. 482-498, 2022
- DOI för Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)
- Ladda ner fulltext (pdf) av Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)
Ingår i European Journal of Medicinal Chemistry, 2021
- DOI för Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation
- Ladda ner fulltext (pdf) av Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation
Ingår i European Journal of Medicinal Chemistry, s. 1346-1360, 2018
Ingår i Bioorganic & Medicinal Chemistry, s. 897-911, 2017
- DOI för Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)
- Ladda ner fulltext (pdf) av Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)
Ingår i Molecular Microbiology, s. 13-25, 2017
Ingår i ChemMedChem, s. 2024-2036, 2016
- DOI för Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with -Arylpropyl Analogues of Fosmidomycin
- Ladda ner fulltext (pdf) av Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with -Arylpropyl Analogues of Fosmidomycin
Expanding the catalytic triad in epoxide hydrolases and related enzymes
Ingår i ACS Catalysis, s. 5702-5713, 2015
- DOI för Expanding the catalytic triad in epoxide hydrolases and related enzymes
- Ladda ner fulltext (pdf) av Expanding the catalytic triad in epoxide hydrolases and related enzymes
Ingår i Journal of Medicinal Chemistry, s. 2988-3001, 2015
- DOI för Synthesis and Bioactivity of beta-Substituted Fosmidomycin Analogues Targeting 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase
- Ladda ner fulltext (pdf) av Synthesis and Bioactivity of beta-Substituted Fosmidomycin Analogues Targeting 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase
Ingår i ChemistryOpen, s. 342-362, 2015
- DOI för Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents
- Ladda ner fulltext (pdf) av Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents
Ingår i Bioscience Reports, s. 865-877, 2014
- DOI för Arabidopsis cytosolic acyl-CoA-binding proteins ACBP4, ACBP5 and ACBP6 have overlapping but distinct roles in seed development
- Ladda ner fulltext (pdf) av Arabidopsis cytosolic acyl-CoA-binding proteins ACBP4, ACBP5 and ACBP6 have overlapping but distinct roles in seed development
DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues
Ingår i Journal of Medicinal Chemistry, s. 6190-6199, 2013
- DOI för DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues
- Ladda ner fulltext (pdf) av DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues
Structural studies on Mycobacterium tuberculosis DXR in complex with the antibiotic FR-900098
Ingår i Acta Crystallographica Section D, s. 134-143, 2012
- DOI för Structural studies on Mycobacterium tuberculosis DXR in complex with the antibiotic FR-900098
- Ladda ner fulltext (pdf) av Structural studies on Mycobacterium tuberculosis DXR in complex with the antibiotic FR-900098
Ingår i MedChemComm, s. 620-626, 2012
Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors
Ingår i Journal of Medicinal Chemistry, s. 2894-2898, 2012
- DOI för Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors
- Ladda ner fulltext (pdf) av Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors
Ingår i Journal of Medicinal Chemistry, s. 4964-4976, 2011
- DOI för Design, Synthesis, and X-ray Crystallographic Studies of alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-D-xylulose 5-Phosphate Reductoisomerase
- Ladda ner fulltext (pdf) av Design, Synthesis, and X-ray Crystallographic Studies of alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-D-xylulose 5-Phosphate Reductoisomerase
Structural and functional studies of mycobacterial IspD enzymes
Ingår i Acta Crystallographica Section D, s. 403-414, 2011
- DOI för Structural and functional studies of mycobacterial IspD enzymes
- Ladda ner fulltext (pdf) av Structural and functional studies of mycobacterial IspD enzymes
Ingår i Plant Molecular Biology, s. 33-45, 2011
- DOI för Expression and beta-glucan binding properties of Scots pine (Pinus sylvestris L.) antimicrobial protein (Sp-AMP)
- Ladda ner fulltext (pdf) av Expression and beta-glucan binding properties of Scots pine (Pinus sylvestris L.) antimicrobial protein (Sp-AMP)
Ingår i The FEBS Journal, s. 793-808, 2011
- DOI för Structures of type B ribose 5-phosphate isomerase from Trypanosoma cruzi shed light on the determinants of sugar specificity in the structural family
- Ladda ner fulltext (pdf) av Structures of type B ribose 5-phosphate isomerase from Trypanosoma cruzi shed light on the determinants of sugar specificity in the structural family
Ingår i Journal of Organic Chemistry, s. 8986-8998, 2011
- DOI för Synthesis of Functionalized Cinnamaldehyde Derivatives by an Oxidative Heck Reaction and Their Use as Starting Materials for Preparation of Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase Inhibitors
- Ladda ner fulltext (pdf) av Synthesis of Functionalized Cinnamaldehyde Derivatives by an Oxidative Heck Reaction and Their Use as Starting Materials for Preparation of Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase Inhibitors
Zinc ions bind to and inhibit activated protein C
Ingår i Thrombosis and Haemostasis, s. 544-553, 2010
- DOI för Zinc ions bind to and inhibit activated protein C
- Ladda ner fulltext (pdf) av Zinc ions bind to and inhibit activated protein C
Conformational Changes and Ligand Recognition of Escherichia coli d-Xylose Binding Protein Revealed
Ingår i Journal of Molecular Biology, s. 657-668, 2010
- DOI för Conformational Changes and Ligand Recognition of Escherichia coli d-Xylose Binding Protein Revealed
- Ladda ner fulltext (pdf) av Conformational Changes and Ligand Recognition of Escherichia coli d-Xylose Binding Protein Revealed
Ingår i Journal of Molecular Biology, s. 504-513, 2009
- DOI för Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors
- Ladda ner fulltext (pdf) av Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors
Ingår i Bioorganic & Medicinal Chemistry Letters, s. 6649-6654, 2009
Ingår i Carbohydrate Research, s. 869-880, 2009
The first crystal structures of a family 19 class IV chitinase: the enzyme from Norway spruce
Ingår i Plant Molecular Biology, s. 277-289, 2009
- DOI för The first crystal structures of a family 19 class IV chitinase: the enzyme from Norway spruce
- Ladda ner fulltext (pdf) av The first crystal structures of a family 19 class IV chitinase: the enzyme from Norway spruce
Ingår i The FEBS Journal, s. 2116-2124, 2009
Ingår i Protein Science, s. 1275-1284, 2008
- DOI för Removal of distal protein-water hydrogen bonds in a plant epoxide hydrolase increases catalytic turnover but decreases thermostability
- Ladda ner fulltext (pdf) av Removal of distal protein-water hydrogen bonds in a plant epoxide hydrolase increases catalytic turnover but decreases thermostability
Ingår i Journal of Molecular Biology, s. 109-119, 2008
- DOI för X-ray structure of Candida antarctica lipase A shows a novel lid structure and a likely mode of interfacial activation
- Ladda ner fulltext (pdf) av X-ray structure of Candida antarctica lipase A shows a novel lid structure and a likely mode of interfacial activation
Ingår i Journal of Molecular Biology, s. 217-228, 2008
- DOI för Crystal Structures of Mammalian Glutamine Synthetases Illustrate Substrate-Induced Conformational Changes and Provide Opportunities for Drug and Herbicide Design
- Ladda ner fulltext (pdf) av Crystal Structures of Mammalian Glutamine Synthetases Illustrate Substrate-Induced Conformational Changes and Provide Opportunities for Drug and Herbicide Design
Ingår i Bioorganic & Medicinal Chemistry, s. 5501-5513, 2008
- DOI för Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery
- Ladda ner fulltext (pdf) av Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery
Ingår i Journal of Molecular Biology, s. 622-633, 2008
- DOI för Structural, biochemical and in vivo investigations of the threonine synthase from Mycobacterium tuberculosis
- Ladda ner fulltext (pdf) av Structural, biochemical and in vivo investigations of the threonine synthase from Mycobacterium tuberculosis
Ingår i Journal of Molecular Biology, s. 667-679, 2008
- DOI för D-ribose-5-phosphate isomerase B from Escherichia coli is also a functional D-allose-6-phosphate isomerase, while the Mycobacterium tuberculosis enzyme is not
- Ladda ner fulltext (pdf) av D-ribose-5-phosphate isomerase B from Escherichia coli is also a functional D-allose-6-phosphate isomerase, while the Mycobacterium tuberculosis enzyme is not
Ingår i The FEBS Journal, s. 3695-3703, 2007
Ingår i Journal of Biological Chemistry, s. 19905-19916, 2007
Ingår i Combinatorial chemistry & high throughput screening, s. 783-789, 2007
Ingår i Acta Crystallogr D Biol Crystallogr, s. 807-13, 2006
X-ray structure of potato epoxide hydrolase sheds light on its substrate specificity
Ingår i Protein Science, s. 1628-1637, 2006
Ingår i Acta Crystallogr. Section D Biol. Crystallogr., s. 807-813, 2006
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 10499-10504, 2005
Structure and function of carbonic anhydrases from Mycobacterium tuberculosis.
Ingår i J Biol Chem, s. 18782-9, 2005
Ingår i Proc. Natl. Acad. Sci. USA, s. 10499-10504, 2005
Structure of an atypical epoxide hydrolase from Mycobacterium tuberculosis
Ingår i J Mol Biol, s. 1048-56, 2005
Competitive inhibitors of Mycobacterium tuberculosis ribose-5-phosphate isomerase
Ingår i J Biol Chem, s. 6416-22, 2005
Ingår i Tetrahedron letters, s. 3691-3694, 2005
Ingår i Journal of Molecular Cell Biology, s. 261-274, 2004
Ingår i J Biol Chem, s. 8747-52, 2004
Mycobacterium tuberculosis ribose-5-phosphate isomerase has a known fold, but a novel active site
Ingår i Journal of Molecular Biology, s. 799-809, 2004
Mycobacterium tuberculosis ribose-5-phosphate isomerase has a known fold, but a novel active site.
Ingår i J Mol Biol, s. 799-809, 2004
X-ray structure of peptidyl-prolyl cis-trans isomerase A from Mycobacterium tuberculosis.
Ingår i Eur J Biochem, s. 4107-13, 2004
Ingår i Structure, s. 31-42, 2003
Ingår i Journal of Molecular Biology, 2003
Structure of Rhodococcus erythropolis limonene-1,2-epoxide hydrolase reveals a novel active site.
Ingår i EMBO Journal, s. 2583-2592, 2003
The telltale structures of epoxide hydrolases
Ingår i Drug metabolism reviews (Softcover ed.), s. 365-383, 2003
Ingår i Molecular Microbiology, s. 645-656, 2003
Activation of Ribokinase by Monovalent Cations
Ingår i Journal of Molecular Biology, s. 409-419, 2002
Ingår i FEBS Letters, s. 27-31, 2002
Hinge-bending motion of D-allose-binding protein from Escherichia coli
Ingår i J Biol Chem, s. 14077-84, 2002
Ingår i Structure, s. 111-122, 2000
Induced fit on sugar binding activates ribokinase
Ingår i JOURNAL OF MOLECULAR BIOLOGY, s. 1009-1018, 1999
Ingår i JOURNAL OF MOLECULAR BIOLOGY, s. 1519-1531, 1999
Ingår i JOURNAL OF MOLECULAR BIOLOGY, s. 487-499, 1999
Errors and reproducibility in electron-density map interpretation
Ingår i ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, s. 1309-1319, 1999
Ingår i STRUCTURE, s. 183-193, 1998
Purification, characterization, and crystallization of Escherichia coli ribokinase
Ingår i PROTEIN SCIENCE, s. 2474-2476, 1997
Ingår i JOURNAL OF MOLECULAR BIOLOGY, s. 350-363, 1996
Ingår i Journal of Biological Chemistry, s. 9978-9981, 1995
STRANGE BEDFELLOWS - INTERACTIONS BETWEEN ACIDIC SIDE-CHAINS IN PROTEINS
Ingår i JOURNAL OF MOLECULAR BIOLOGY, s. 96-105, 1995
C-ALPHA-BASED TORSION ANGLES - A SIMPLE TOOL TO ANALYZE PROTEIN CONFORMATIONAL-CHANGES
Ingår i PROTEIN SCIENCE, s. 2118-2122, 1995
Artiklar, forskningsöversikt
Inhibition of Glutamine Synthetase: A Potential Drug Target in Mycobacterium tuberculosis
Ingår i Molecules, s. 13161-13176, 2014
- DOI för Inhibition of Glutamine Synthetase: A Potential Drug Target in Mycobacterium tuberculosis
- Ladda ner fulltext (pdf) av Inhibition of Glutamine Synthetase: A Potential Drug Target in Mycobacterium tuberculosis
Ingår i Journal of the American Chemical Society, s. 7334-7343, 2009
- DOI för Directed Evolution of an Enantioselective Epoxide Hydrolase: Uncovering the Source of Enantioselectivity at Each Evolutionary Stage
- Ladda ner fulltext (pdf) av Directed Evolution of an Enantioselective Epoxide Hydrolase: Uncovering the Source of Enantioselectivity at Each Evolutionary Stage
Manuskript (preprint)
Övriga
Chemotaxis receptors: A progress report on structure and function
Ingår i JOURNAL OF STRUCTURAL BIOLOGY, s. 257-275, 1998