Mats Larhed

N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands

Wannberg, Johan; Gising, Johan; Henriksson, Martin; Vo, Duc Duy et al.

Ingår i European Journal of Medicinal Chemistry, 2024

• DOI för N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
• Ladda ner fulltext (pdf) av N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands

Inhibition of IRAP Enhances the Expression of Pro-Cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells

Stam, Frida; Lind, Sara Florén; Nylander, Erik; Olaniran, Esther et al.

Ingår i International Journal of Molecular Sciences, 2024

• DOI för Inhibition of IRAP Enhances the Expression of Pro-Cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells
• Ladda ner fulltext (pdf) av Inhibition of IRAP Enhances the Expression of Pro-Cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells

Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)

Beveridge, Julia; Söderström, Marcus; Prieto-Díaz, Rubén; Gutierrez-de-Teran, Hugo et al.

Ingår i European Journal of Medicinal Chemistry Reports, 2024

• DOI för Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)
• Ladda ner fulltext (pdf) av Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)

The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds

Gising, Johan; Honarnejad, Saman; Bras, Maaike; Baillie, Gemma L. et al.

Ingår i International Journal of Molecular Sciences, 2024

• DOI för The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds
• Ladda ner fulltext (pdf) av The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds

The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat

Zelleroth, Sofia; Stam, Frida; Nylander, Erik; Ellinor, Kjellgren et al.

Ingår i Hormones and Behavior, 2024

• DOI för The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat
• Ladda ner fulltext (pdf) av The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat

Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation

Engen, Karin; Lundbäck, Thomas; Yadav, Anubha; Puthiyaparambath, Sharathna et al.

Ingår i International Journal of Molecular Sciences, 2024

• DOI för Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation
• Ladda ner fulltext (pdf) av Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation

Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds

Gopalan, Greeshma; Palo-Nieto, Carlos; Petersen, Nadia N.; Hallberg, Mathias et al.

Ingår i Bioorganic & Medicinal Chemistry, 2022

• DOI för Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds
• Ladda ner fulltext (pdf) av Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds

2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands

Roy, Tamal; Petersen, Nadia N.; Gopalan, Greeshma; Gising, Johan et al.

Ingår i Bioorganic & Medicinal Chemistry, 2022

• DOI för 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands
• Ladda ner fulltext (pdf) av 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands

N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands

Wannberg, Johan; Gising, Johan; Lindman, Jens; Salander, Jessica et al.

Ingår i Bioorganic & Medicinal Chemistry, 2021

• DOI för N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands

From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase

Hallberg, Mathias; Larhed, Mats

Ingår i Frontiers in Pharmacology, 2020

• DOI för From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase
• Ladda ner fulltext (pdf) av From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase

Regio- and Stereoselective Synthesis of Allylic Spiroethers (Spirobenzofuranes) via an Intramolecular Mizoroki-Heck Reaction

Adeyemi, Ahmed; Odell, Luke R.; Larhed, Mats

Ingår i Journal of Organic Chemistry, s. 7648-7657, 2020

• DOI för Regio- and Stereoselective Synthesis of Allylic Spiroethers (Spirobenzofuranes) via an Intramolecular Mizoroki-Heck Reaction

Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors

Engen, Karin; Reddy Vanga, Sudarsana; Lundbäck, Thomas; Agalo, Faith et al.

Ingår i ChemistryOpen, s. 325-337, 2020

• DOI för Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors
• Ladda ner fulltext (pdf) av Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors

A Series of Analogues to the AT₂R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode

Isaksson, Rebecka; Lindman, Jens; Wannberg, Johan; Sallander, Jessica et al.

Ingår i ChemistryOpen, s. 114-125, 2019

• DOI för A Series of Analogues to the AT₂R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode
• Ladda ner fulltext (pdf) av A Series of Analogues to the AT₂R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode

Regio- and Stereoselective Synthesis of Spirooxindoles via Mizoroki-Heck Coupling of Aryl Iodides

Adeyemi, Ahmed; Wetzel, Alexander; Bergman, Joakim; Brånalt, Jonas et al.

Ingår i Synlett, s. 82-88, 2019

• DOI för Regio- and Stereoselective Synthesis of Spirooxindoles via Mizoroki-Heck Coupling of Aryl Iodides

Palladium-Catalyzed Molybdenum Hexacarbonyl-Mediated Gas-Free Carbonylative Reactions

Åkerbladh, Linda; Odell, Luke R.; Larhed, Mats

Ingår i Synlett, s. 141-155, 2019

• DOI för Palladium-Catalyzed Molybdenum Hexacarbonyl-Mediated Gas-Free Carbonylative Reactions

Selective Synthesis of Spirooxindoles by an Intramolecular Heck-Mizoroki Reaction

Roy, Tamal; Brandt, Peter; Wetzel, Alexander; Bergman, Joakim et al.

Ingår i Organic Letters, s. 2738-2741, 2017

• DOI för Selective Synthesis of Spirooxindoles by an Intramolecular Heck-Mizoroki Reaction

Non-peptide AT2-receptor agonists

Larhed, Mats; Hallberg, Mathias; Hallberg, Anders

Ingår i Medicinal Chemistry Reviews, 2016

Identification of Drug-Like Inhibitors of Insulin-Regulated Aminopeptidase Through Small-Molecule Screening

Engen, Karin; Rosenström, Ulrika; Axelsson, Hanna; Konda, Vivek et al.

Ingår i Assay and drug development technologies, s. 180-193, 2016

• DOI för Identification of Drug-Like Inhibitors of Insulin-Regulated Aminopeptidase Through Small-Molecule Screening

Synthesis of 4-Quinolones via a Carbonylative Sonogashira Cross-Coupling Using Molybdenum Hexacarbonyl as a CO Source

Åkerbladh, Linda; Nordeman, Patrik; Wejdemar, Matyas; Odell, Luke R. et al.

Ingår i Journal of Organic Chemistry, s. 1464-1471, 2015

• DOI för Synthesis of 4-Quinolones via a Carbonylative Sonogashira Cross-Coupling Using Molybdenum Hexacarbonyl as a CO Source

Aspartic protease inhibitors containing tertiary alcohol transition-state mimics

Motwani, Hitesh V.; De Rosa, Maria; Odell, Luke R.; Hallberg, Anders et al.

Ingår i European Journal of Medicinal Chemistry, s. 462-490, 2014

• DOI för Aspartic protease inhibitors containing tertiary alcohol transition-state mimics

Synthesis of P1 '-Functionalized Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol

De Rosa, Maria; Unge, Johan; Motwani, Hitesh V.; Rosenquist, Asa et al.

Ingår i Journal of Medicinal Chemistry, s. 6444-6457, 2014

• DOI för Synthesis of P1 '-Functionalized Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol

Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors

Wu, Xiongyu; Öhrngren, Per; Joshi, Advait A.; Trejos, Alejandro et al.

Ingår i Journal of Medicinal Chemistry, s. 2724-2736, 2012

• DOI för Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors

Evaluation of a Nonresonant Microwave Applicator for Continuous-Flow Chemistry Applications

Öhrngren, Per; Fardost, Ashkan; Russo, Francesco; Fagrell, Magnus et al.

Ingår i Organic Process Research & Development, s. 1053-1063, 2012

• DOI för Evaluation of a Nonresonant Microwave Applicator for Continuous-Flow Chemistry Applications

Aminocarbonylations Employing Mo(CO)(6) and a Bridged Two-Vial System: Allowing the Use of Nitro Group Substituted Aryl Iodides and Aryl Bromides

Nordeman, Patrik; Odell, Luke R; Larhed, Mats

Ingår i Journal of Organic Chemistry, s. 11393-11398, 2012

• DOI för Aminocarbonylations Employing Mo(CO)(6) and a Bridged Two-Vial System: Allowing the Use of Nitro Group Substituted Aryl Iodides and Aryl Bromides

Microwave-assisted synthesis of small molecules targeting the infectious diseases tuberculosis, HIV/AIDS, malaria and hepatitis C

Gising, Johan; Odell, Luke R.; Larhed, Mats

Ingår i Organic and biomolecular chemistry, s. 2713-2729, 2012

• DOI för Microwave-assisted synthesis of small molecules targeting the infectious diseases tuberculosis, HIV/AIDS, malaria and hepatitis C

Transmetallation Versus β-Hydride Elimination: The Role of 1,4 Benzoquinone in Chelation-Controlled Arylation Reactions with Arylboronic Acids

Sköld, Christian; Kleimark, Jonatan; Trejos, Alejandro; Odell, Luke R. et al.

Ingår i Chemistry - A European Journal, s. 4714-4722, 2012

• DOI för Transmetallation Versus β-Hydride Elimination: The Role of 1,4 Benzoquinone in Chelation-Controlled Arylation Reactions with Arylboronic Acids
• Ladda ner fulltext (pdf) av Transmetallation Versus β-Hydride Elimination: The Role of 1,4 Benzoquinone in Chelation-Controlled Arylation Reactions with Arylboronic Acids

From virtual screening to selective angiotensin II type 2 receptor ligands: discovery of a novel scaffold

Patel, Jayendra Z.; Sandberg, Lars; Wannberg, Johan; Söderström, Marcus et al.

Ingår i Results in Chemistry, 2026

• DOI för From virtual screening to selective angiotensin II type 2 receptor ligands: discovery of a novel scaffold
• Ladda ner fulltext (pdf) av From virtual screening to selective angiotensin II type 2 receptor ligands: discovery of a novel scaffold

New high affinity AT2 receptor ligands comprising a 2-methyl substituted phenylthiophene scaffold

Gising, Johan; Wannberg, Johan; Isaksson, Rebecka; Sallander, Jessica et al.

Ingår i Bioorganic & Medicinal Chemistry, 2026

• DOI för New high affinity AT2 receptor ligands comprising a 2-methyl substituted phenylthiophene scaffold
• Ladda ner fulltext (pdf) av New high affinity AT2 receptor ligands comprising a 2-methyl substituted phenylthiophene scaffold

The effects of insulin-regulated aminopeptidase inhibition with HA08 on recognition memory acquisition and spatial working memory under reversed circadian conditions in male rats

Stam, Frida; Lind, Sara Florén; Zelleroth, Sofia; Badrd'din, Sally et al.

Ingår i IBRO Neuroscience Reports, s. 854-861, 2025

• DOI för The effects of insulin-regulated aminopeptidase inhibition with HA08 on recognition memory acquisition and spatial working memory under reversed circadian conditions in male rats
• Ladda ner fulltext (pdf) av The effects of insulin-regulated aminopeptidase inhibition with HA08 on recognition memory acquisition and spatial working memory under reversed circadian conditions in male rats

Insulin-regulated aminopeptidase inhibitor C9 restores cellular activity in methadone-damaged primary cell cultures

Stam, Frida; Lind, Sara Florén; Nylander, Erik; Olaniran Håkansson, Esther et al.

Ingår i Neuroscience Letters, 2025

• DOI för Insulin-regulated aminopeptidase inhibitor C9 restores cellular activity in methadone-damaged primary cell cultures
• Ladda ner fulltext (pdf) av Insulin-regulated aminopeptidase inhibitor C9 restores cellular activity in methadone-damaged primary cell cultures

Benzylhydroxamic Acids as IRAP Inhibitors: Sulfonamide Variations

Beveridge, Julia; Söderström, Marcus; Balestri, Lorenzo; Prieto-Díaz, Rubén et al.

Ingår i Synlett, s. 2666-2670, 2025

• DOI för Benzylhydroxamic Acids as IRAP Inhibitors: Sulfonamide Variations
• Ladda ner fulltext (pdf) av Benzylhydroxamic Acids as IRAP Inhibitors: Sulfonamide Variations

From virtual screening to selective angiotensin II type 2 receptor ligands: discovery of a novel scaffold

Patel, Jayendra Z.; Sandberg, Lars; Wannberg, Johan; Söderström, Marcus et al.

Ingår i Results in Chemistry, 2026

• DOI för From virtual screening to selective angiotensin II type 2 receptor ligands: discovery of a novel scaffold
• Ladda ner fulltext (pdf) av From virtual screening to selective angiotensin II type 2 receptor ligands: discovery of a novel scaffold

New high affinity AT2 receptor ligands comprising a 2-methyl substituted phenylthiophene scaffold

Gising, Johan; Wannberg, Johan; Isaksson, Rebecka; Sallander, Jessica et al.

Ingår i Bioorganic & Medicinal Chemistry, 2026

• DOI för New high affinity AT2 receptor ligands comprising a 2-methyl substituted phenylthiophene scaffold
• Ladda ner fulltext (pdf) av New high affinity AT2 receptor ligands comprising a 2-methyl substituted phenylthiophene scaffold

The effects of insulin-regulated aminopeptidase inhibition with HA08 on recognition memory acquisition and spatial working memory under reversed circadian conditions in male rats

Stam, Frida; Lind, Sara Florén; Zelleroth, Sofia; Badrd'din, Sally et al.

Ingår i IBRO Neuroscience Reports, s. 854-861, 2025

• DOI för The effects of insulin-regulated aminopeptidase inhibition with HA08 on recognition memory acquisition and spatial working memory under reversed circadian conditions in male rats
• Ladda ner fulltext (pdf) av The effects of insulin-regulated aminopeptidase inhibition with HA08 on recognition memory acquisition and spatial working memory under reversed circadian conditions in male rats

Insulin-regulated aminopeptidase inhibitor C9 restores cellular activity in methadone-damaged primary cell cultures

Stam, Frida; Lind, Sara Florén; Nylander, Erik; Olaniran Håkansson, Esther et al.

Ingår i Neuroscience Letters, 2025

• DOI för Insulin-regulated aminopeptidase inhibitor C9 restores cellular activity in methadone-damaged primary cell cultures
• Ladda ner fulltext (pdf) av Insulin-regulated aminopeptidase inhibitor C9 restores cellular activity in methadone-damaged primary cell cultures

Benzylhydroxamic Acids as IRAP Inhibitors: Sulfonamide Variations

Beveridge, Julia; Söderström, Marcus; Balestri, Lorenzo; Prieto-Díaz, Rubén et al.

Ingår i Synlett, s. 2666-2670, 2025

• DOI för Benzylhydroxamic Acids as IRAP Inhibitors: Sulfonamide Variations
• Ladda ner fulltext (pdf) av Benzylhydroxamic Acids as IRAP Inhibitors: Sulfonamide Variations

Novel Macrocyclic Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP): Design, Synthesis and Evaluation

Olaniran Håkansson, Esther; Balestri, Lorenzo Jacopo Ilic; Puthiyaparambath, Sharathna; Moes, Sebastian et al.

Ingår i RSC Medicinal chemistry, s. 5059-5069, 2025

• DOI för Novel Macrocyclic Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP): Design, Synthesis and Evaluation
• Ladda ner fulltext (pdf) av Novel Macrocyclic Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP): Design, Synthesis and Evaluation

A Diastereoselective Mizoroki-Heck Reaction for Synthesis of Spirooxindole-Based Nonnatural Amino Acids Using a Boc-Protected Amine Chiral Auxiliary

Lindman, Jens; Puthiyaparambath, Sharathna; Gising, Johan; Odell, Luke R. et al.

Ingår i Synlett, s. 2009-2013, 2025

• DOI för A Diastereoselective Mizoroki-Heck Reaction for Synthesis of Spirooxindole-Based Nonnatural Amino Acids Using a Boc-Protected Amine Chiral Auxiliary
• Ladda ner fulltext (pdf) av A Diastereoselective Mizoroki-Heck Reaction for Synthesis of Spirooxindole-Based Nonnatural Amino Acids Using a Boc-Protected Amine Chiral Auxiliary

N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands

Wannberg, Johan; Gising, Johan; Henriksson, Martin; Vo, Duc Duy et al.

Ingår i European Journal of Medicinal Chemistry, 2024

• DOI för N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
• Ladda ner fulltext (pdf) av N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands

Inhibition of IRAP Enhances the Expression of Pro-Cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells

Stam, Frida; Lind, Sara Florén; Nylander, Erik; Olaniran, Esther et al.

Ingår i International Journal of Molecular Sciences, 2024

• DOI för Inhibition of IRAP Enhances the Expression of Pro-Cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells
• Ladda ner fulltext (pdf) av Inhibition of IRAP Enhances the Expression of Pro-Cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells

Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)

Beveridge, Julia; Söderström, Marcus; Prieto-Díaz, Rubén; Gutierrez-de-Teran, Hugo et al.

Ingår i European Journal of Medicinal Chemistry Reports, 2024

• DOI för Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)
• Ladda ner fulltext (pdf) av Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)

The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds

Gising, Johan; Honarnejad, Saman; Bras, Maaike; Baillie, Gemma L. et al.

Ingår i International Journal of Molecular Sciences, 2024

• DOI för The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds
• Ladda ner fulltext (pdf) av The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds

The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat

Zelleroth, Sofia; Stam, Frida; Nylander, Erik; Ellinor, Kjellgren et al.

Ingår i Hormones and Behavior, 2024

• DOI för The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat
• Ladda ner fulltext (pdf) av The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat

Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation

Engen, Karin; Lundbäck, Thomas; Yadav, Anubha; Puthiyaparambath, Sharathna et al.

Ingår i International Journal of Molecular Sciences, 2024

• DOI för Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation
• Ladda ner fulltext (pdf) av Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation

Two-chamber Aminocarbonylation of Aryl Bromides and Triflates Using Amino Acids as Nucleophiles

Lindman, Jens; Yadav, Anubha; Gising, Johan; Larhed, Mats

Ingår i Journal of Organic Chemistry, s. 12978-12985, 2023

• DOI för Two-chamber Aminocarbonylation of Aryl Bromides and Triflates Using Amino Acids as Nucleophiles
• Ladda ner fulltext (pdf) av Two-chamber Aminocarbonylation of Aryl Bromides and Triflates Using Amino Acids as Nucleophiles

Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures

Stam, Frida; Lind, Sara Florén; Schroff, Anja; Zelleroth, Sofia et al.

Ingår i Current Issues in Molecular Biology, s. 5000-5012, 2022

• DOI för Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures
• Ladda ner fulltext (pdf) av Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures

Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds

Gopalan, Greeshma; Palo-Nieto, Carlos; Petersen, Nadia N.; Hallberg, Mathias et al.

Ingår i Bioorganic & Medicinal Chemistry, 2022

• DOI för Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds
• Ladda ner fulltext (pdf) av Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds

2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands

Roy, Tamal; Petersen, Nadia N.; Gopalan, Greeshma; Gising, Johan et al.

Ingår i Bioorganic & Medicinal Chemistry, 2022

• DOI för 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands
• Ladda ner fulltext (pdf) av 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands

Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)

Lu, Lu; Åkerbladh, Linda; Ahmad, Shabbir; Konda, Vivek et al.

Ingår i ACS - Infectious Diseases, s. 482-498, 2022

• DOI för Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)
• Ladda ner fulltext (pdf) av Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)

Diastereoselective Synthesis of N-Methylspiroindolines by Intramolecular Mizoroki–Heck Annulations

Lindman, Jens; Gopalan, Greeshma; Palo-Nieto, Carlos; Brandt, Peter et al.

Ingår i ACS Omega, 2022

• DOI för Diastereoselective Synthesis of N-Methylspiroindolines by Intramolecular Mizoroki–Heck Annulations
• Ladda ner fulltext (pdf) av Diastereoselective Synthesis of N-Methylspiroindolines by Intramolecular Mizoroki–Heck Annulations

N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands

Wannberg, Johan; Gising, Johan; Lindman, Jens; Salander, Jessica et al.

Ingår i Bioorganic & Medicinal Chemistry, 2021

• DOI för N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands

¹⁸F-Radiolabeling and Preliminary Evaluation of a HSP₉₀ ligand

Nordeman, Patrik; Jayendra, Z. P.; Briard, E.; Li, Su-Chen et al.

Ingår i European Journal of Pharmaceutical Sciences, 2021

• DOI för ¹⁸F-Radiolabeling and Preliminary Evaluation of a HSP₉₀ ligand

Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor

Mpakali, Anastasia; Saridakis, Emmanuel; Giastas, Petros; Maben, Zachary et al.

Ingår i ACS Medicinal Chemistry Letters, s. 1429-1434, 2020

• DOI för Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor

Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer-Optimization of the Affinity towards PSMA by Linker Modification in Murine Model

Lundmark, Fanny; Abouzayed, Ayman; Mitran, Bogdan; Rinne, Sara S. et al.

Ingår i Pharmaceutics, 2020

• DOI för Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer-Optimization of the Affinity towards PSMA by Linker Modification in Murine Model
• Ladda ner fulltext (pdf) av Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer-Optimization of the Affinity towards PSMA by Linker Modification in Murine Model

Regio- and Stereoselective Synthesis of Allylic Spiroethers (Spirobenzofuranes) via an Intramolecular Mizoroki-Heck Reaction

Adeyemi, Ahmed; Odell, Luke R.; Larhed, Mats

Ingår i Journal of Organic Chemistry, s. 7648-7657, 2020

• DOI för Regio- and Stereoselective Synthesis of Allylic Spiroethers (Spirobenzofuranes) via an Intramolecular Mizoroki-Heck Reaction

Macrocyclic Peptidomimetics as Inhibitors of Insulin-Regulated Aminopeptidase (IRAP)

Barlow, Nicholas; Reddy Vanga, Sudarsana; Sävmarker, Jonas; Sandström, Anja et al.

Ingår i RSC Medicinal chemistry, s. 234-244, 2020

• DOI för Macrocyclic Peptidomimetics as Inhibitors of Insulin-Regulated Aminopeptidase (IRAP)

Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors

Engen, Karin; Reddy Vanga, Sudarsana; Lundbäck, Thomas; Agalo, Faith et al.

Ingår i ChemistryOpen, s. 325-337, 2020

• DOI för Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors
• Ladda ner fulltext (pdf) av Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors

Direct stimulation of angiotensin II type 2 receptor reduces nitric oxide production in lipopolysaccharide treated mouse macrophages

Isaksson, Rebecka; Casselbrant, Anna; Elebring, Erik; Hallberg, Mathias et al.

Ingår i European Journal of Pharmacology, 2020

• DOI för Direct stimulation of angiotensin II type 2 receptor reduces nitric oxide production in lipopolysaccharide treated mouse macrophages
• Ladda ner fulltext (pdf) av Direct stimulation of angiotensin II type 2 receptor reduces nitric oxide production in lipopolysaccharide treated mouse macrophages

Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer

Abouzayed, Ayman; Yim, Cheng-Bin; Mitran, Bogdan; Rinne, Sara S. et al.

Ingår i Pharmaceutics, 2019

• DOI för Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer
• Ladda ner fulltext (pdf) av Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer

A Series of Analogues to the AT₂R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode

Isaksson, Rebecka; Lindman, Jens; Wannberg, Johan; Sallander, Jessica et al.

Ingår i ChemistryOpen, s. 114-125, 2019

• DOI för A Series of Analogues to the AT₂R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode
• Ladda ner fulltext (pdf) av A Series of Analogues to the AT₂R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode

Synthesis and preclinical evaluation of the CRTH2 antagonist [¹¹C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass

Eriksson, Jonas; Roy, Tamal; Sawadjoon, Supaporn; Bachmann, Kim et al.

Ingår i Nuclear Medicine and Biology, s. 1-10, 2019

• DOI för Synthesis and preclinical evaluation of the CRTH2 antagonist [¹¹C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass
• Ladda ner fulltext (pdf) av Synthesis and preclinical evaluation of the CRTH2 antagonist [¹¹C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass

Bispecific GRPR-antagonistic anti-PSMA/GRPR heterodimer for PET and SPECT diagnostic imaging of prostate cancer

Mitran, Bogdan; Varasteh, Zohreh; Abouzayed, Ayman; Rinne, Sara S. et al.

Ingår i Cancers, 2019

• DOI för Bispecific GRPR-antagonistic anti-PSMA/GRPR heterodimer for PET and SPECT diagnostic imaging of prostate cancer
• Ladda ner fulltext (pdf) av Bispecific GRPR-antagonistic anti-PSMA/GRPR heterodimer for PET and SPECT diagnostic imaging of prostate cancer

Regio- and Stereoselective Synthesis of Spirooxindoles via Mizoroki-Heck Coupling of Aryl Iodides

Adeyemi, Ahmed; Wetzel, Alexander; Bergman, Joakim; Brånalt, Jonas et al.

Ingår i Synlett, s. 82-88, 2019

• DOI för Regio- and Stereoselective Synthesis of Spirooxindoles via Mizoroki-Heck Coupling of Aryl Iodides

Trastuzumab cotreatment improves survival of mice with PC-3 prostate cancer xenografts treated with the GRPR antagonist 177Lu-DOTAGA-PEG2-RM26

Mitran, Bogdan; Rinne, Sara S.; Konijnenberg, Mark W.; Maina, Theodosia et al.

Ingår i International Journal of Cancer, s. 3347-3358, 2019

• DOI för Trastuzumab cotreatment improves survival of mice with PC-3 prostate cancer xenografts treated with the GRPR antagonist 177Lu-DOTAGA-PEG2-RM26
• Ladda ner fulltext (pdf) av Trastuzumab cotreatment improves survival of mice with PC-3 prostate cancer xenografts treated with the GRPR antagonist 177Lu-DOTAGA-PEG2-RM26

Palladium-Catalyzed Molybdenum Hexacarbonyl-Mediated Gas-Free Carbonylative Reactions

Åkerbladh, Linda; Odell, Luke R.; Larhed, Mats

Ingår i Synlett, s. 141-155, 2019

• DOI för Palladium-Catalyzed Molybdenum Hexacarbonyl-Mediated Gas-Free Carbonylative Reactions

Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides

Reddy Vanga, Sudarsana; Sävmarker, Jonas; Ng, Leelee; Larhed, Mats et al.

Ingår i ACS Omega, s. 4509-4521, 2018

• DOI för Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides
• Ladda ner fulltext (pdf) av Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides

A convenient transesterification method for synthesis of AT2 receptor ligands with improved stability in human liver microsomes

Wannberg, Johan; Isaksson, Rebecka; Bremberg, Ulf; Backlund, Maria et al.

Ingår i Bioorganic & Medicinal Chemistry Letters, s. 519-522, 2018

• DOI för A convenient transesterification method for synthesis of AT2 receptor ligands with improved stability in human liver microsomes

Lignin depolymerization to monophenolic compounds in a flow-through system

Kumaniaev, Ivan; Subbotina, Elena; Sävmarker, Jonas; Larhed, Mats et al.

Ingår i Green Chemistry, s. 5767-5771, 2017

• DOI för Lignin depolymerization to monophenolic compounds in a flow-through system
• Ladda ner fulltext (pdf) av Lignin depolymerization to monophenolic compounds in a flow-through system

Synthesis of ¹¹C-Labelled Ureas by Palladium(II)-Mediated Oxidative Carbonylation

Bergman, Sara; Brandt, Peter; Nordeman, Patrik; Larhed, Mats et al.

Ingår i Molecules, 2017

• DOI för Synthesis of ¹¹C-Labelled Ureas by Palladium(II)-Mediated Oxidative Carbonylation
• Ladda ner fulltext (pdf) av Synthesis of ¹¹C-Labelled Ureas by Palladium(II)-Mediated Oxidative Carbonylation

Synthesis of 4H-Benzo[e][1,3]oxazin-4-ones by a Carbonylation-Cyclization Domino Reaction of ortho-Halophenols and Cyanamide

Åkerbladh, Linda; Chow, Shiao Y.; Odell, Luke R.; Larhed, Mats

Ingår i ChemistryOpen, s. 620-628, 2017

• DOI för Synthesis of 4H-Benzo[e][1,3]oxazin-4-ones by a Carbonylation-Cyclization Domino Reaction of ortho-Halophenols and Cyanamide
• Ladda ner fulltext (pdf) av Synthesis of 4H-Benzo[e][1,3]oxazin-4-ones by a Carbonylation-Cyclization Domino Reaction of ortho-Halophenols and Cyanamide

Continuous Flow Synthesis under High-Temperature/High-Pressure Conditions Using a Resistively Heated Flow Reactor

Adeyemi, Ahmed; Bergman, Joakim; Branalt, Jonas; Sävmarker, Jonas et al.

Ingår i Organic Process Research & Development, s. 947-955, 2017

• DOI för Continuous Flow Synthesis under High-Temperature/High-Pressure Conditions Using a Resistively Heated Flow Reactor

High Contrast PET Imaging of GRPR Expression in Prostate Cancer Using Cobalt-Labeled Bombesin Antagonist RM26

Mitran, Bogdan; Thisgaard, Helge; Rosenström, Ulrika; Dam, Johan Hygum et al.

Ingår i Contrast Media & Molecular Imaging, 2017

• DOI för High Contrast PET Imaging of GRPR Expression in Prostate Cancer Using Cobalt-Labeled Bombesin Antagonist RM26
• Ladda ner fulltext (pdf) av High Contrast PET Imaging of GRPR Expression in Prostate Cancer Using Cobalt-Labeled Bombesin Antagonist RM26

Synthesis and In Vitro Evaluation of 5-Substituted Benzovesamicol Analogs containing N-Substituted Amides as Potential Positron Emission Tomography Tracers for the Vesicular Acetylcholine Transporter

Roslin, Sara; De Rosa, Maria; Deuther-Conrad, Winnie; Eriksson, Jonas et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 5095-5106, 2017

• DOI för Synthesis and In Vitro Evaluation of 5-Substituted Benzovesamicol Analogs containing N-Substituted Amides as Potential Positron Emission Tomography Tracers for the Vesicular Acetylcholine Transporter

Palladium(0)-Catalyzed Carbonylative One-Pot Synthesis of N-Acylguanidines

Åkerbladh, Linda; Schembri, Luke S; Larhed, Mats; Odell, Luke R.

Ingår i Journal of Organic Chemistry, s. 12520-12529, 2017

• DOI för Palladium(0)-Catalyzed Carbonylative One-Pot Synthesis of N-Acylguanidines

Regio- and Stereoselective Synthesis of Functionalized Cyclopentene Derivatives via Mizoroki-Heck Reactions.

Wetzel, Alexander; Bergman, Joakim; Brandt, Peter; Larhed, Mats et al.

Ingår i Organic Letters, s. 1602-1605, 2017

• DOI för Regio- and Stereoselective Synthesis of Functionalized Cyclopentene Derivatives via Mizoroki-Heck Reactions.

Route to 3-Amidino Indoles via Pd(II)-Catalyzed C-H Bond Activation

Rydfjord, Jonas; Skillinghaug, Bobo; Brandt, Peter; Odell, Luke R. et al.

Ingår i Organic Letters, s. 4066-4069, 2017

• DOI för Route to 3-Amidino Indoles via Pd(II)-Catalyzed C-H Bond Activation

Selective Synthesis of Spirooxindoles by an Intramolecular Heck-Mizoroki Reaction

Roy, Tamal; Brandt, Peter; Wetzel, Alexander; Bergman, Joakim et al.

Ingår i Organic Letters, s. 2738-2741, 2017

• DOI för Selective Synthesis of Spirooxindoles by an Intramolecular Heck-Mizoroki Reaction

Synthesis of C-11-labeled Sulfonyl Carbamates through a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols, and [C-11]CO

Stevens, Marc; Chow, Shiao; Estrada, Sergio; Eriksson, Jonas et al.

Ingår i ChemistryOpen, s. 566-573, 2016

• DOI för Synthesis of C-11-labeled Sulfonyl Carbamates through a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols, and [C-11]CO
• Ladda ner fulltext (pdf) av Synthesis of C-11-labeled Sulfonyl Carbamates through a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols, and [C-11]CO

Binding to and Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Macrocyclic Disulfides Enhances Spine Density

Diwakarla, Shanti; Nylander, Erik; Grönbladh, Alfhild; Reddy Vanga, Sudarsana et al.

Ingår i Molecular Pharmacology, s. 413-424, 2016

• DOI för Binding to and Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Macrocyclic Disulfides Enhances Spine Density

Synthesis of ¹¹C-labelled Sulfonyl Carbamates via a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols and [¹¹C]CO

Stevens, Marc; Chow, Chow; Estrada, Sergio; Eriksson, Jonas et al.

Ingår i ChemistryOpen, s. 566-573, 2016

• DOI för Synthesis of ¹¹C-labelled Sulfonyl Carbamates via a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols and [¹¹C]CO
• Ladda ner fulltext (pdf) av Synthesis of ¹¹C-labelled Sulfonyl Carbamates via a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols and [¹¹C]CO

Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

Diwakarla, Shanti; Nylander, Erik; Grönbladh, Alfhild; Vanga, Sudarsana Reddy et al.

Ingår i ACS Chemical Neuroscience, s. 1383-1392, 2016

• DOI för Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

Selection of optimal chelator improves the contrast of GRPR imaging using bombesin analogue RM26.

Mitran, Bogdan; Varasteh, Zohreh; Selvaraju, Ram Kumar; Lindeberg, Gunnar et al.

Ingår i International journal of oncology, s. 2124-2134, 2016

• DOI för Selection of optimal chelator improves the contrast of GRPR imaging using bombesin analogue RM26.

Identification of Drug-Like Inhibitors of Insulin-Regulated Aminopeptidase Through Small-Molecule Screening

Engen, Karin; Rosenström, Ulrika; Axelsson, Hanna; Konda, Vivek et al.

Ingår i Assay and drug development technologies, s. 180-193, 2016

• DOI för Identification of Drug-Like Inhibitors of Insulin-Regulated Aminopeptidase Through Small-Molecule Screening

Rapid and straightforward transesterification of sulfonyl carbamates

Isaksson, Rebecka; Kumpina, Ilze; Larhed, Mats; Wannberg, Johan

Ingår i Tetrahedron Letters, s. 1476-1478, 2016

• DOI för Rapid and straightforward transesterification of sulfonyl carbamates

Microwave Promoted Transcarbamylation Reaction of Sulfonylcarbamates under Continuous-Flow Conditions

Kumpina, Ilze; Isaksson, Rebecka; Sävmarker, Jonas; Wannberg, Johan et al.

Ingår i Organic Process Research & Development, s. 440-445, 2016

• DOI för Microwave Promoted Transcarbamylation Reaction of Sulfonylcarbamates under Continuous-Flow Conditions

Microwave Heated Continuous Flow Palladium(II)-Catalyzed Desulfitative Synthesis of Aryl Ketones

Skillinghaug, Bobo; Rydfjord, Jonas; Sävmarker, Jonas; Larhed, Mats

Ingår i Organic Process Research & Development, s. 2005-2011, 2016

• DOI för Microwave Heated Continuous Flow Palladium(II)-Catalyzed Desulfitative Synthesis of Aryl Ketones

Synthesis of enantiopure angiotensin II type 2 receptor [AT(2)R] antagonist EMA401

Wakchaure, Prasad B.; Bremberg, Ulf; Wannberg, Johan; Larhed, Mats

Ingår i Tetrahedron, s. 6881-6887, 2015

• DOI för Synthesis of enantiopure angiotensin II type 2 receptor [AT(2)R] antagonist EMA401

Chemical Conversion of (CO2)-C-11 to (CO)-C-11 via Silacarboxylic Acids: Applications in Palladium-Mediated Carbonylations

Nordeman, Patrik; Friis, Stig D.; Andersen, Thomas L.; Audrain, Helene et al.

Ingår i Journal of labelled compounds & radiopharmaceuticals, 2015

Influence of chelators on targeting properties of In-111 and Ga-68 labeled GRPR antagonist

Orlova, Anna; Varasteh, Zohreh; Mitran, Bogdan; Rosestedt, Maria et al.

Ingår i Journal of labelled compounds & radiopharmaceuticals, 2015

Development of radiocobalt-labeled GRPR antagonist NOTA-PEG2-RM26.

Mitran, Bogdan; Varasteh, Zohreh; Rosenström, Ulrika; Tolmachev, Vladimir et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2015

N-Substituted pyrazole-3-carboxamides as inhibitors of human 15-lipoxygenase

Pelcman, Benjamin; Sanin, Andrei; Nilsson, Peter; Schaal, Wesley et al.

Ingår i Bioorganic & Medicinal Chemistry Letters, s. 3017-3023, 2015

• DOI för N-Substituted pyrazole-3-carboxamides as inhibitors of human 15-lipoxygenase

3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1

Pelcman, Benjamin; Sanin, Andrei; Nilsson, Peter; No, Kiyo et al.

Ingår i Bioorganic & Medicinal Chemistry Letters, s. 3024-3029, 2015

• DOI för 3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1

The effect of macrocyclic chelators on the targeting properties of the ⁶⁸Ga-labeled gastrin releasing peptide receptor antagonist PEG₂-RM26

Varasteh, Zohreh; Mitran, Bogdan; Rosenström, Ulrika; Velikyan, Irina et al.

Ingår i Nuclear Medicine and Biology, s. 446-454, 2015

• DOI för The effect of macrocyclic chelators on the targeting properties of the ⁶⁸Ga-labeled gastrin releasing peptide receptor antagonist PEG₂-RM26

Virtual Screening for Transition State Analogue Inhibitors of IRAP Based on Quantum Mechanically Derived Reaction Coordinates

Svensson, Fredrik; Engen, Karin; Lundbäck, Thomas; Larhed, Mats et al.

Ingår i Journal of Chemical Information and Modeling, s. 1984-1993, 2015

• DOI för Virtual Screening for Transition State Analogue Inhibitors of IRAP Based on Quantum Mechanically Derived Reaction Coordinates

Rapid and Efficient Conversion of (CO2)-C-11 to (CO)-C-11 through Silacarboxylic Acids: Applications in Pd-Mediated Carbonylations

Nordeman, Patrik; Friis, Stig D.; Andersen, Thomas L.; Audrain, Helene et al.

Ingår i Chemistry - A European Journal, s. 17601-17604, 2015

• DOI för Rapid and Efficient Conversion of (CO2)-C-11 to (CO)-C-11 through Silacarboxylic Acids: Applications in Pd-Mediated Carbonylations

Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents

Russo, Francesco; Gising, Johan; Åkerbladh, Linda; Roos, Annette K. et al.

Ingår i ChemistryOpen, s. 342-362, 2015

• DOI för Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents
• Ladda ner fulltext (pdf) av Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents

Site-Specific Radioiodination of HER2-Targeting Affibody Molecules using 4-Iodophenethylmaleimide Decreases Renal Uptake of Radioactivity

Strand, Joanna; Nordeman, Patrik; Honarvar, Hadis; Altai, Mohamed et al.

Ingår i ChemistryOpen, s. 174-182, 2015

• DOI för Site-Specific Radioiodination of HER2-Targeting Affibody Molecules using 4-Iodophenethylmaleimide Decreases Renal Uptake of Radioactivity
• Ladda ner fulltext (pdf) av Site-Specific Radioiodination of HER2-Targeting Affibody Molecules using 4-Iodophenethylmaleimide Decreases Renal Uptake of Radioactivity

Synthesis of 4-Quinolones via a Carbonylative Sonogashira Cross-Coupling Using Molybdenum Hexacarbonyl as a CO Source

Åkerbladh, Linda; Nordeman, Patrik; Wejdemar, Matyas; Odell, Luke R. et al.

Ingår i Journal of Organic Chemistry, s. 1464-1471, 2015

• DOI för Synthesis of 4-Quinolones via a Carbonylative Sonogashira Cross-Coupling Using Molybdenum Hexacarbonyl as a CO Source

Palladium-Catalyzed Carbonylation of Aryl Iodides with Sulfinamides

Belfrage, Anna Karin; Wakchaure, Prasad; Larhed, Mats; Sandström, Anja

Ingår i European Journal of Organic Chemistry, s. 7069-7074, 2015

• DOI för Palladium-Catalyzed Carbonylation of Aryl Iodides with Sulfinamides

The Effect of Mini-PEG-Based Spacer Length on Binding and Pharmacokinetic Properties of a Ga-68-Labeled NOTA-Conjugated Antagonistic Analog of Bombesin

Varasteh, Zohreh; Rosenström, Ulrika; Velikyan, Irina; Mitran, Bogdan et al.

Ingår i Molecules, s. 10455-10472, 2014

• DOI för The Effect of Mini-PEG-Based Spacer Length on Binding and Pharmacokinetic Properties of a Ga-68-Labeled NOTA-Conjugated Antagonistic Analog of Bombesin
• Ladda ner fulltext (pdf) av The Effect of Mini-PEG-Based Spacer Length on Binding and Pharmacokinetic Properties of a Ga-68-Labeled NOTA-Conjugated Antagonistic Analog of Bombesin

Continuous flow chemistry with a non-resonant microwave applicator

Rydfjord, Jonas; Sävmarker, Jonas; Konda, Vivek; Skillinghaug, Bobo et al.

Ingår i Abstracts of Papers of the American Chemical Society, 2014

Palladium(II) catalyzed desulfitative coupling reactions of sodium aryl sulfinates and nitriles: Scope, limitations, and mechanistic studies

Skillinghaug, Bobo; Sköld, Christian; Behrends, Malte; Sävmarker, Jonas et al.

Ingår i Abstracts of Papers of the American Chemical Society, 2014

Continuous flow chemistry utilizing silicon carbide (SiC) reactors

Konda, Vivekananda R.; Veron, Jean-Baptiste; Larhed, Mats

Ingår i Abstracts of Papers of the American Chemical Society, 2014

Nonresonant microwave heated continuous flow synthesis in medicinal chemistry

Engen, Karin; Sävmarker, Jonas; Lundback, Thomas; Wannberg, Johan et al.

Ingår i Abstracts of Papers of the American Chemical Society, 2014

Synthesis and evaluation of isoleucine derived angiotensin II AT(2) receptor ligands

Veron, Jean-Baptiste; Joshi, Advait; Wallinder, Charlotta; Larhed, Mats et al.

Ingår i Bioorganic & Medicinal Chemistry Letters, s. 476-479, 2014

• DOI för Synthesis and evaluation of isoleucine derived angiotensin II AT(2) receptor ligands

Microwave Heated Flow Synthesis of Spiro-oxindole Dihydroquinazolinone Based IRAP Inhibitors

Engen, Karin; Sävmarker, Jonas; Rosenström, Ulrika; Wannberg, Johan et al.

Ingår i Organic Process Research & Development, s. 1582-1588, 2014

• DOI för Microwave Heated Flow Synthesis of Spiro-oxindole Dihydroquinazolinone Based IRAP Inhibitors

Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Gising, Johan; Belfrage, Anna Karin; Alogheli, Hiba; Ehrenberg, Angelica et al.

Ingår i Journal of Medicinal Chemistry, s. 1790-1801, 2014

• DOI för Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides

Borhade, Sanjay R; Rosenström, Ulrika; Sävmarker, Jonas; Lundbäck, Thomas et al.

Ingår i ChemistryOpen, s. 256-263, 2014

• DOI för Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides

Safe Palladium-Catalyzed Cross-Couplings with Microwave Heating Using Continuous-Flow Silicon Carbide Reactors

Konda, Vivek; Rydfjord, Jonas; Sävmarker, Jonas; Larhed, Mats

Ingår i Organic Process Research & Development, s. 1413-1418, 2014

• DOI för Safe Palladium-Catalyzed Cross-Couplings with Microwave Heating Using Continuous-Flow Silicon Carbide Reactors

Synthesis of P1 '-Functionalized Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol

De Rosa, Maria; Unge, Johan; Motwani, Hitesh V.; Rosenquist, Asa et al.

Ingår i Journal of Medicinal Chemistry, s. 6444-6457, 2014

• DOI för Synthesis of P1 '-Functionalized Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol

Synthesis and Labelling of a Piperazine-Based Library of ¹¹C-Labeled Ligands for Imaging of the Vesicular Acetylcholine Transporter

Bergman, Sara; Estrada, Sergio; Hall, Håkan; Rahman, Rashidur et al.

Ingår i Journal of labelled compounds & radiopharmaceuticals, s. 525-532, 2014

• DOI för Synthesis and Labelling of a Piperazine-Based Library of ¹¹C-Labeled Ligands for Imaging of the Vesicular Acetylcholine Transporter

N-Aryl Isoleucine Derivatives as Angiotensin II AT(2) Receptor Ligands

Behrends, Malte; Wallinder, Charlotta; Wieckowska, Anna; Guimond, Marie-Odile et al.

Ingår i ChemistryOpen, s. 65-75, 2014

• DOI för N-Aryl Isoleucine Derivatives as Angiotensin II AT(2) Receptor Ligands
• Ladda ner fulltext (pdf) av N-Aryl Isoleucine Derivatives as Angiotensin II AT(2) Receptor Ligands

11C-Labeling of a Potent Hydroxyethylamine BACE-1 Inhibitor and Evaluation in vitro and in vivo

Nordeman, Patrik; Estrada, Sergio; Odell, Luke R; Larhed, Mats et al.

Ingår i Nuclear Medicine and Biology, s. 536-543, 2014

• DOI för 11C-Labeling of a Potent Hydroxyethylamine BACE-1 Inhibitor and Evaluation in vitro and in vivo

C-11-Labeling of a potent hydroxyethylamine BACE-1 inhibitor and evaluation in vitro and in vivo

Nordeman, Patrik; Estrada, Sergio; Odell, Luke; Larhed, Mats et al.

Ingår i Nuclear Medicine and Biology, s. 536-543, 2014

• DOI för C-11-Labeling of a potent hydroxyethylamine BACE-1 inhibitor and evaluation in vitro and in vivo

An Improved Palladium(II)-Catalyzed Method for the Synthesis of Aryl Ketones from Aryl Carboxylic Acids and Organonitriles

Axelsson, Linda; Veron, Jean-Baptiste; Sävmarker, Jonas; Lindh, Jonas et al.

Ingår i Tetrahedron Letters, s. 2376-2380, 2014

• DOI för An Improved Palladium(II)-Catalyzed Method for the Synthesis of Aryl Ketones from Aryl Carboxylic Acids and Organonitriles

Palladium(II)-Catalyzed Desulfitative Synthesis of Aryl Ketones from Sodium Arylsulfinates and Nitriles: Scope, Limitations, and Mechanistic Studies

Skillinghaug, Bobo; Sköld, Christian; Rydfjord, Jonas; Svensson, Fredrik et al.

Ingår i Journal of Organic Chemistry, s. 12018-12032, 2014

• DOI för Palladium(II)-Catalyzed Desulfitative Synthesis of Aryl Ketones from Sodium Arylsulfinates and Nitriles: Scope, Limitations, and Mechanistic Studies

Palladium(II)-Catalyzed Decarboxylative Heck Arylations of Acyclic Electron-Rich Olefins with Internal Selectivity

Fardost, Ashkan; Lindh, Jonas; Sjöberg, Per J. R.; Larhed, Mats

Ingår i Advanced Synthesis and Catalysis, s. 870-878, 2014

• DOI för Palladium(II)-Catalyzed Decarboxylative Heck Arylations of Acyclic Electron-Rich Olefins with Internal Selectivity

Influence of chelators on biodistribution and targeting properties of GRPR antagonist

Mitran, Bogdan; Varasteh, Zohreh; Rosestedt, Maria; Velikyan, Irina et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2014

Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice

Tehler, Ulrika; Fagerberg, Jonas H.; Svensson, Richard; Larhed, Mats et al.

Ingår i Journal of Medicinal Chemistry, s. 2690-2694, 2013

• DOI för Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice

Palladium-Catalyzed Carbonylative Synthesis of N-Cyanobenzamides from Aryl Iodides/Bromides and Cyanamide

Mane, Rajendra S; Nordeman, Patrik; Odell, Luke R; Larhed, Mats

Ingår i Tetrahedron Letters, s. 6912-6915, 2013

• DOI för Palladium-Catalyzed Carbonylative Synthesis of N-Cyanobenzamides from Aryl Iodides/Bromides and Cyanamide

In Vitro and In Vivo Evaluation of a F-18-Labeled High Affinity NOTA Conjugated Bombesin Antagonist as a PET Ligand for GRPR-Targeted Tumor Imaging

Varasteh, Zohreh; Åberg, Ola; Velikyan, Irina; Lindeberg, Gunnar et al.

Ingår i PLOS ONE, 2013

• DOI för In Vitro and In Vivo Evaluation of a F-18-Labeled High Affinity NOTA Conjugated Bombesin Antagonist as a PET Ligand for GRPR-Targeted Tumor Imaging
• Ladda ner fulltext (pdf) av In Vitro and In Vivo Evaluation of a F-18-Labeled High Affinity NOTA Conjugated Bombesin Antagonist as a PET Ligand for GRPR-Targeted Tumor Imaging

Aminocarbonylation of 4-Iodo-1H-imidazoles with an Amino Acid Amide Nucleophile: Synthesis of Constrained H-Phe-Phe-NH2 Analogues

Skogh, Anna; Fransson, Rebecca; Sköld, Christian; Larhed, Mats et al.

Ingår i Journal of Organic Chemistry, s. 12251-12256, 2013

• DOI för Aminocarbonylation of 4-Iodo-1H-imidazoles with an Amino Acid Amide Nucleophile: Synthesis of Constrained H-Phe-Phe-NH2 Analogues

Design and Synthesis of P1-P3 Macrocyclic Tertiary-Alcohol-Comprising HIV-1 Protease Inhibitors

Joshi, Advait; Véron, Jean-Baptiste; Unge, Johan; Rosenquist, Asa et al.

Ingår i Journal of Medicinal Chemistry, s. 8999-9007, 2013

• DOI för Design and Synthesis of P1-P3 Macrocyclic Tertiary-Alcohol-Comprising HIV-1 Protease Inhibitors

GRPR antagonist NOTA-P2-RM26 labeled with fluorine-18: radiochemistry, in vitro and in vivo evaluation

Varasteh, Zohreh; Åberg, Ola; Lindberg, G.; Antoni, Gunnar et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2013

Temperature measurements with two different IR sensors in a continuous-flow microwave heated system

Rydfjord, Jonas; Svensson, Fredrik; Fagrell, Magnus; Sävmarker, Jonas et al.

Ingår i Beilstein Journal of Organic Chemistry, s. 2079-2087, 2013

• DOI för Temperature measurements with two different IR sensors in a continuous-flow microwave heated system

Decarboxylative Palladium(II)-Catalyzed Synthesis of Aryl Amidines from Aryl Carboxylic Acids: Development and Mechanistic Investigation

Rydfjord, Jonas; Svensson, Fredrik; Trejos, Alejandro; Sjöberg, Per J. R. et al.

Ingår i Chemistry - A European Journal, s. 13803-13810, 2013

• DOI för Decarboxylative Palladium(II)-Catalyzed Synthesis of Aryl Amidines from Aryl Carboxylic Acids: Development and Mechanistic Investigation

Synthesis and Characterization of a High-Affinity NOTA-Conjugated Bombesin Antagonist for GRPR-Targeted Tumor Imaging

Varasteh, Zohreh; Velikyan, Irina; Lindeberg, Gunnar; Sörensen, Jens et al.

Ingår i Bioconjugate chemistry, s. 1144-1153, 2013

• DOI för Synthesis and Characterization of a High-Affinity NOTA-Conjugated Bombesin Antagonist for GRPR-Targeted Tumor Imaging
• Ladda ner fulltext (pdf) av Synthesis and Characterization of a High-Affinity NOTA-Conjugated Bombesin Antagonist for GRPR-Targeted Tumor Imaging

One-Pot, Two-Step, Microwave-Assisted Palladium-Catalyzed Conversion of Aryl Alcohols to Aryl Fluorides via Aryl Nonaflates

Wannberg, Johan; Wallinder, Charlotta; Unlusoy, Meltem; Sköld, Christian et al.

Ingår i Journal of Organic Chemistry, s. 4184-4189, 2013

• DOI för One-Pot, Two-Step, Microwave-Assisted Palladium-Catalyzed Conversion of Aryl Alcohols to Aryl Fluorides via Aryl Nonaflates

(AlF)-F-18-labelling of NOTA-P2-RM26 and its evaluation as a PET ligand for GRPR/BB2

Åberg, Ola; Varasteh, Zohreh; Lindeberg, Gunnar; Larhed, Mats et al.

Ingår i Journal of labelled compounds & radiopharmaceuticals, 2013

Synthesis of antimalarial compounds fosmidomycin and FR900098 through N- or P-alkylation reactions

Suresh, Surisetti; Shyamraj, Dharavath; Larhed, Mats

Ingår i Tetrahedron, s. 1183-1188, 2013

• DOI för Synthesis of antimalarial compounds fosmidomycin and FR900098 through N- or P-alkylation reactions

Theoretical and Experimental Investigation of Palladium(II)-Catalyzed Decarboxylative Addition of Arenecarboxylic Acid to Nitrile

Svensson, Fredrik; Mane, Rajendra S.; Sävmarker, Jonas; Larhed, Mats et al.

Ingår i Organometallics, s. 490-497, 2013

• DOI för Theoretical and Experimental Investigation of Palladium(II)-Catalyzed Decarboxylative Addition of Arenecarboxylic Acid to Nitrile

DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues

Jansson, Anna; Więckowska, Anna; Björkelid, Christofer; Yahiaoui, Samir et al.

Ingår i Journal of Medicinal Chemistry, s. 6190-6199, 2013

• DOI för DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues
• Ladda ner fulltext (pdf) av DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues

Synthesis and biological evaluation of a piperazine-based library of C-11-Labeled PET tracers for imaging of the vesicular acetylcholine transporter

Bergman, Sara; Blomgren, Andreas; Hall, Håkan; Larhed, Mats et al.

Ingår i Journal of labelled compounds & radiopharmaceuticals, 2013

Diarylated Ethanones from Mo(CO)(6)-Mediated and Microwave-Assisted Palladium-Catalysed Carbonylative Negishi Cross-Couplings

Motwani, Hitesh V.; Larhed, Mats

Ingår i European Journal of Organic Chemistry, s. 4729-4733, 2013

• DOI för Diarylated Ethanones from Mo(CO)(6)-Mediated and Microwave-Assisted Palladium-Catalysed Carbonylative Negishi Cross-Couplings

Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors

Wu, Xiongyu; Öhrngren, Per; Joshi, Advait A.; Trejos, Alejandro et al.

Ingår i Journal of Medicinal Chemistry, s. 2724-2736, 2012

• DOI för Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors

Evaluation of a Nonresonant Microwave Applicator for Continuous-Flow Chemistry Applications

Öhrngren, Per; Fardost, Ashkan; Russo, Francesco; Fagrell, Magnus et al.

Ingår i Organic Process Research & Development, s. 1053-1063, 2012

• DOI för Evaluation of a Nonresonant Microwave Applicator for Continuous-Flow Chemistry Applications

Synthesis, biological evaluation and X-ray crystallographic studies of imidazo[1,2-a]-pyridine based Mycobacterium tuberculosis glutamine synthetase inhibitors

Nordqvist, Anneli; Nilsson, Mikael T.; Lagerlund, Olof; Muthas, Daniel et al.

Ingår i MedChemComm, s. 620-626, 2012

• DOI för Synthesis, biological evaluation and X-ray crystallographic studies of imidazo[1,2-a]-pyridine based Mycobacterium tuberculosis glutamine synthetase inhibitors

Molybdenum Hexacarbonyl Mediated CO Gas-Free Carbonylative Reactions

Odell, Luke R.; Russo, Francesco; Larhed, Mats

Ingår i Synlett, s. 685-698, 2012

• DOI för Molybdenum Hexacarbonyl Mediated CO Gas-Free Carbonylative Reactions

Aminocarbonylations Employing Mo(CO)(6) and a Bridged Two-Vial System: Allowing the Use of Nitro Group Substituted Aryl Iodides and Aryl Bromides

Nordeman, Patrik; Odell, Luke R; Larhed, Mats

Ingår i Journal of Organic Chemistry, s. 11393-11398, 2012

• DOI för Aminocarbonylations Employing Mo(CO)(6) and a Bridged Two-Vial System: Allowing the Use of Nitro Group Substituted Aryl Iodides and Aryl Bromides

Direct Palladium(II)-Catalyzed Synthesis of Arylamidines from Aryltrifluoroborates

Sävmarker, Jonas; Rydfjord, Jonas; Gising, Johan; Odell, Luke R. et al.

Ingår i Organic Letters, s. 2394-2397, 2012

• DOI för Direct Palladium(II)-Catalyzed Synthesis of Arylamidines from Aryltrifluoroborates

Oxidative Heck Reactions Using Aryltrifluoroborates and Aryl N-Methyliminodiacetic Acid (MIDA) Boronates

Sävmarker, Jonas; Lindh, Jonas; Nilsson, Peter; Sjöberg, Per et al.

Ingår i ChemistryOpen, s. 140-146, 2012

• DOI för Oxidative Heck Reactions Using Aryltrifluoroborates and Aryl N-Methyliminodiacetic Acid (MIDA) Boronates

Site-specific radioiodination of HER2-targeting affibody molecules using iodophenetylmaleimide decreases renal uptake of radioactivity

Strand, Joanna; Nordeman, Patrik; Honarvar, Hadis; Altai, Mohamed et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2012

Synthesis and characterization of a high affinity NOTA-conjugated bombesin antagonist for GRPR-targeted tumor imaging

Varasteh, Zohreh; Velikyan, Irina; Lindeberg, Gunnar; Sörensen, Jens et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2012

A non-resonant microwave applicator fully dedicated to continuous flow chemistry

Fardost, Ashkan; Russo, Francesco; Larhed, Mats

Ingår i Chimica oggi, s. 14-16, 2012

Synthesis of functionalized furopyrazines as restricted dipeptidomimetics

Claerhout, Stijn; Sharma, Sweta; Sköld, Christian; Cavaluzzo, Claudia et al.

Ingår i Tetrahedron, s. 3019-3029, 2012

• DOI för Synthesis of functionalized furopyrazines as restricted dipeptidomimetics

Microwave-assisted synthesis of small molecules targeting the infectious diseases tuberculosis, HIV/AIDS, malaria and hepatitis C

Gising, Johan; Odell, Luke R.; Larhed, Mats

Ingår i Organic and biomolecular chemistry, s. 2713-2729, 2012

• DOI för Microwave-assisted synthesis of small molecules targeting the infectious diseases tuberculosis, HIV/AIDS, malaria and hepatitis C

Transmetallation Versus β-Hydride Elimination: The Role of 1,4 Benzoquinone in Chelation-Controlled Arylation Reactions with Arylboronic Acids

Sköld, Christian; Kleimark, Jonatan; Trejos, Alejandro; Odell, Luke R. et al.

Ingår i Chemistry - A European Journal, s. 4714-4722, 2012

• DOI för Transmetallation Versus β-Hydride Elimination: The Role of 1,4 Benzoquinone in Chelation-Controlled Arylation Reactions with Arylboronic Acids
• Ladda ner fulltext (pdf) av Transmetallation Versus β-Hydride Elimination: The Role of 1,4 Benzoquinone in Chelation-Controlled Arylation Reactions with Arylboronic Acids

Development of Stereocontrolled Palladium(II)-Catalyzed Domino Heck/Suzuki β, α-Diarylation Reactions with Chelating Vinyl Ethers and Arylboronic Acids

Trejos, Alejandro; Odell, Luke R.; Larhed, Mats

Ingår i ChemistryOpen, s. 49-56, 2012

• DOI för Development of Stereocontrolled Palladium(II)-Catalyzed Domino Heck/Suzuki β, α-Diarylation Reactions with Chelating Vinyl Ethers and Arylboronic Acids
• Ladda ner fulltext (pdf) av Development of Stereocontrolled Palladium(II)-Catalyzed Domino Heck/Suzuki β, α-Diarylation Reactions with Chelating Vinyl Ethers and Arylboronic Acids

Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors

Gising, Johan; Nilsson, Mikael T; Odell, Luke R; Yahiaoui, Samir et al.

Ingår i Journal of Medicinal Chemistry, s. 2894-2898, 2012

• DOI för Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors
• Ladda ner fulltext (pdf) av Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors

Design, Synthesis, and X-ray Crystallographic Studies of alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-D-xylulose 5-Phosphate Reductoisomerase

Andaloussi, Mounir; Henriksson, Lena M.; Wieckowska, Anna; Lindh, Martin et al.

Ingår i Journal of Medicinal Chemistry, s. 4964-4976, 2011

• DOI för Design, Synthesis, and X-ray Crystallographic Studies of alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-D-xylulose 5-Phosphate Reductoisomerase
• Ladda ner fulltext (pdf) av Design, Synthesis, and X-ray Crystallographic Studies of alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-D-xylulose 5-Phosphate Reductoisomerase

Microwave-Assisted Palladium(II)-Catalyzed Synthesis of Aryl Ketones from Aryl Sulfinates and Direct ESI-MS Studies Thereof

Behrends, Malte; Sävmarker, Jonas; Sjöberg, Per J. R.; Larhed, Mats

Ingår i ACS Catalysis, s. 1455-1459, 2011

• DOI för Microwave-Assisted Palladium(II)-Catalyzed Synthesis of Aryl Ketones from Aryl Sulfinates and Direct ESI-MS Studies Thereof

Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors

Lazorova, Lucia; Hubatsch, Ina; Ekegren, Jenny K.; Gising, Johan et al.

Ingår i Journal of Pharmaceutical Sciences, s. 3763-3772, 2011

• DOI för Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors

Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: An attempt to improve the activity against Mycobacterium tuberculosis

Andaloussi, Mounir; Lindh, Martin; Björkelid, Christofer; Suresh, Surisetti et al.

Ingår i Bioorganic & Medicinal Chemistry Letters, s. 5403-5407, 2011

• DOI för Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: An attempt to improve the activity against Mycobacterium tuberculosis

Hiv-1 Protease Inhibitors with a Tertiary Alcohol Containing a Transition-State Mimic and Various P2/P1´ Substituents

Öhrngren, Per; Wu, Xiongyu; Persson, Magnus; Ekegren, Jenny et al.

Ingår i MedChemComm, s. 701-709, 2011

• DOI för Hiv-1 Protease Inhibitors with a Tertiary Alcohol Containing a Transition-State Mimic and Various P2/P1´ Substituents

Chelation-Mediated Palladium(II)-Catalyzed Domino Heck-Mizoroki/Suzuki-Miyaura Reactions Using Arylboronic Acids: Increasing Scope and Mechanistic Understanding

Yahiaoui, Samir; Fardost, Ashkan; Trejos, Alejandro; Larhed, Mats

Ingår i Journal of Organic Chemistry, s. 2433-2438, 2011

• DOI för Chelation-Mediated Palladium(II)-Catalyzed Domino Heck-Mizoroki/Suzuki-Miyaura Reactions Using Arylboronic Acids: Increasing Scope and Mechanistic Understanding

Investigation of alpha-phenylnorstatine and alpha-benzylnorstatine as transition state isostere motifs in the search for new BACE-1 inhibitors

Wångsell, Fredrik; Nordeman, Patrik; Sävmarker, Jonas; Emanuelsson, Rikard et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 145-155, 2011

• DOI för Investigation of alpha-phenylnorstatine and alpha-benzylnorstatine as transition state isostere motifs in the search for new BACE-1 inhibitors

Microwave-Assisted Synthesis of Weinreb and MAP Aryl Amides via Pd-Catalyzed Heck Aminocarbonylation Using Mo(CO)(6) or W(CO)(6)

Wieckowska, Anna; Fransson, Rebecca; Odell, Luke R.; Larhed, Mats

Ingår i Journal of Organic Chemistry, s. 978-981, 2011

• DOI för Microwave-Assisted Synthesis of Weinreb and MAP Aryl Amides via Pd-Catalyzed Heck Aminocarbonylation Using Mo(CO)(6) or W(CO)(6)

Non-peptide AT2-receptor agonists

Steckelings, U. Muscha; Larhed, Mats; Hallberg, Anders; Widdop, Robert E. et al.

Ingår i Current opinion in pharmacology (Print), s. 187-192, 2011

• DOI för Non-peptide AT2-receptor agonists

Richard F. Heck: Nobel Laureate in Chemistry

Odell, Luke R; Larhed, Mats

Ingår i Les Prix Nobel, s. 133-138, 2011

Synthesis of Functionalized Cinnamaldehyde Derivatives by an Oxidative Heck Reaction and Their Use as Starting Materials for Preparation of Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase Inhibitors

Nordqvist, Anneli; Björkelid, Christofer; Andaloussi, Mounir; Jansson, Anna M. et al.

Ingår i Journal of Organic Chemistry, s. 8986-8998, 2011

• DOI för Synthesis of Functionalized Cinnamaldehyde Derivatives by an Oxidative Heck Reaction and Their Use as Starting Materials for Preparation of Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase Inhibitors
• Ladda ner fulltext (pdf) av Synthesis of Functionalized Cinnamaldehyde Derivatives by an Oxidative Heck Reaction and Their Use as Starting Materials for Preparation of Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase Inhibitors

Discovery of Achiral Inhibitors of the Hepatitis C Virus NS3 Protease based on 2(1H)-pyrazinones

Örtqvist, Pernilla; Gising, Johan; Ehrenberg, Angelica; Vema, Aparna et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 6512-6525, 2010

• DOI för Discovery of Achiral Inhibitors of the Hepatitis C Virus NS3 Protease based on 2(1H)-pyrazinones

Hepatitis C protease inhibitors based on 2(1H)-pyrazinones

Gising, Johan; Belfrage, Anna Karin; Örtqvist, Pernilla; Larhed, Mats et al.

Ingår i Abstracts of Papers of the American Chemical Society, 2010

Synthesis of a small library of non-symmetric cyclic sulfamide HIV-1 protease inhibitors

Ax, Anna; Joshi, Advait A.; Orrling, Kristina M.; Vrang, Lotta et al.

Ingår i Tetrahedron, s. 4049-4056, 2010

• DOI för Synthesis of a small library of non-symmetric cyclic sulfamide HIV-1 protease inhibitors

Synthesis of aryl ketones by palladium(II)-catalyzed decarboxylative addition of benzoic acids to nitriles

Lindh, Jonas; Sjöberg, Per J. R.; Larhed, Mats

Ingår i Angewandte Chemie International Edition, s. 7733-7737, 2010

• DOI för Synthesis of aryl ketones by palladium(II)-catalyzed decarboxylative addition of benzoic acids to nitriles

HIV-1 Protease Inhibitors with a Transition-State Mimic Comprising a Tertiary Alcohol: Improved Antiviral Activity in Cells

Mahalingam, A. Kannan; Axelsson, Linda; Ekegren, Jenny K.; Wannberg, Johan et al.

Ingår i Journal of Medicinal Chemistry, s. 607-615, 2010

• DOI för HIV-1 Protease Inhibitors with a Transition-State Mimic Comprising a Tertiary Alcohol: Improved Antiviral Activity in Cells

Synthesis and evaluation of a ¹¹C-labelled angiotensin II AT₂ receptor ligand

Åberg, Ola; Stevens, Marc; Lindh, Jonas; Wallinder, Charlotta et al.

Ingår i Journal of labelled compounds & radiopharmaceuticals, s. 616-624, 2010

• DOI för Synthesis and evaluation of a ¹¹C-labelled angiotensin II AT₂ receptor ligand

Continuous Flow Palladium(II): Catalyzed Oxidative Heck Reactions with Arylboronic Acids

Odell, Luke R.; Lindh, Jonas; Gustafsson, Tomas; Larhed, Mats

Ingår i European Journal of Organic Chemistry, s. 2270-2274, 2010

• DOI för Continuous Flow Palladium(II): Catalyzed Oxidative Heck Reactions with Arylboronic Acids

A straightforward microwave method for rapid synthesis of N-1, C-6 functionalized 3,5-dichloro-2(1H)-pyrazinones

Gising, Johan; Örtqvist, Pernilla; Sandström, Anja; Larhed, Mats

Ingår i Organic and biomolecular chemistry, s. 2809-2815, 2009

• DOI för A straightforward microwave method for rapid synthesis of N-1, C-6 functionalized 3,5-dichloro-2(1H)-pyrazinones

Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors

Nilsson, Mikael T.; Krajewski, Wojciech W.; Srinivasa, Bachally R.; Yahiaoui, Samir et al.

Ingår i Journal of Molecular Biology, s. 504-513, 2009

• DOI för Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors
• Ladda ner fulltext (pdf) av Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors

Palladium(II)-catalyzed coupling reactions with a chelating vinyl ether and arylboronic acids: a new Heck/Suzuki domino diarylation reaction

Trejos, Alejandro; Fardost, Ashkan; Yahiaoui, Samir; Larhed, Mats

Ingår i Chemical Communications, s. 7587-7589, 2009

• DOI för Palladium(II)-catalyzed coupling reactions with a chelating vinyl ether and arylboronic acids: a new Heck/Suzuki domino diarylation reaction

Functionalized 3-amino-imidazo[1,2-a]pyridines: A novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitors

Odell, Luke R.; Nilsson, Mikael T.; Gising, Johan; Lagerlund, Olof et al.

Ingår i Bioorganic & Medicinal Chemistry Letters, s. 4790-4793, 2009

• DOI för Functionalized 3-amino-imidazo[1,2-a]pyridines: A novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitors

α-Substituted Norstatines as the Transistion-State Mimic in Inhibitors of Multiple Digestive Vacuole Malaria Aspartic Proteases

Orrling, Kristina M.; Marzahn, Melissa; Gutiérrez-de-Terán, Hugo; Åqvist, Johan et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 5933-5949, 2009

• DOI för α-Substituted Norstatines as the Transistion-State Mimic in Inhibitors of Multiple Digestive Vacuole Malaria Aspartic Proteases

Design and synthesis of BACE-1 inhibitors utilizing a tertiary hydroxyl motif as the transition state mimic

Wångsell, Fredrik; Russo, Francesco; Sävmarker, Jonas; Rosenqvist, Åsa et al.

Ingår i Bioorganic & Medicinal Chemistry Letters, s. 4711-4714, 2009

• DOI för Design and synthesis of BACE-1 inhibitors utilizing a tertiary hydroxyl motif as the transition state mimic

Synthesis and evaluation of a new class of tertiary alcohol based BACE-1 inhibitors

Russo, Francesco; Wångsell, Fredrik; Sävmarker, Jonas; Jacobsson, Micael et al.

Ingår i Tetrahedron, s. 10047-10059, 2009

• DOI för Synthesis and evaluation of a new class of tertiary alcohol based BACE-1 inhibitors

Aminocarbonylations of Alkenyl Phosphates, Chlorides, Bromides and Triflates with Mo(CO)₆ as a Solid CO source

Lagerlund, Olof; Mantel, Mette L. H.; Larhed, Mats

Ingår i Tetrahedron, s. 7646-7652, 2009

• DOI för Aminocarbonylations of Alkenyl Phosphates, Chlorides, Bromides and Triflates with Mo(CO)₆ as a Solid CO source

Microwave-assisted palladium(II)-catalyzed Heck reactions

Lindh, Jonas; Larhed, Mats

Ingår i Chimica oggi, s. 11-14, 2009

Synthesis of styrenes by palladium(II)-catalyzed vinylation of arylboronic acids and aryltrifluoroborates by using vinyl acetate

Lindh, Jonas; Sävmarker, Jonas; Nilsson, Peter; Sjöberg, Per J R et al.

Ingår i Chemistry - A European Journal, s. 4630-4636, 2009

• DOI för Synthesis of styrenes by palladium(II)-catalyzed vinylation of arylboronic acids and aryltrifluoroborates by using vinyl acetate

Microwave-promoted palladium(II)-catalyzed C-P bond formation by using arylboronic acids or aryltrifluoroborates.

Andaloussi, Mounir; Lindh, Jonas; Sävmarker, Jonas; Sjöberg, Per J.R. et al.

Ingår i Chemistry - A European Journal, s. 13069-13074, 2009

• DOI för Microwave-promoted palladium(II)-catalyzed C-P bond formation by using arylboronic acids or aryltrifluoroborates.

Stereoselective Heck arylation of a functionalized cyclopentenyl ether using (S)-N-methyl-pyrrolidine as the stereochemical controller

Trejos, Alejandro; Sävmarker, Jonas; Schlummer, Stefanie; Datta, Gopal K. et al.

Ingår i Tetrahedron, s. 8746-8751, 2008

• DOI för Stereoselective Heck arylation of a functionalized cyclopentenyl ether using (S)-N-methyl-pyrrolidine as the stereochemical controller

Microwave-promoted aminocarbonylation of aryl triflates using Mo(CO)₆ as a solid CO source

Odell, Luke R.; Sävmarker, Jonas; Larhed, Mats

Ingår i Tetrahedron Letters, s. 6115-6118, 2008

• DOI för Microwave-promoted aminocarbonylation of aryl triflates using Mo(CO)₆ as a solid CO source

Microwave-assisted, Mo(CO)₆-mediated, palladium-catalyzed amino-carbonylation of aryl halides using allylamine: from exploration to scale-up

Appukkuttan, Prasad; Axelsson, Linda; Van der Eycken, Erik; Larhed, Mats

Ingår i Tetrahedron Letters, s. 5625-5628, 2008

• DOI för Microwave-assisted, Mo(CO)₆-mediated, palladium-catalyzed amino-carbonylation of aryl halides using allylamine: from exploration to scale-up

Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery

Nordqvist, Anneli; Nilsson, Mikael T.; Röttger, Svenja; Odell, Luke R. et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 5501-5513, 2008

• DOI för Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery
• Ladda ner fulltext (pdf) av Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery

Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors

Pasquini, Serena; Mugnaini, Claudia; Tintori, Cristina; Botta, Maurizio et al.

Ingår i Journal of Medicinal Chemistry, s. 5125-9, 2008

• DOI för Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors

Two-carbon-elongated HIV-1 protease inhibitors with a tertiary-alcohol-containing transition-state mimic

Wu, Xiongyu; Ohrngren, Per; Ekegren, Jenny K; Unge, Johan et al.

Ingår i Journal of Medicinal Chemistry, s. 1053-1057, 2008

• DOI för Two-carbon-elongated HIV-1 protease inhibitors with a tertiary-alcohol-containing transition-state mimic

Fast, acid-free, and selective lactamization of lactones in ionic liquids

Orrling, Kristina M; Wu, Xiongyu; Russo, Francesco; Larhed, Mats

Ingår i Journal of Organic Chemistry, s. 8627-30, 2008

• DOI för Fast, acid-free, and selective lactamization of lactones in ionic liquids

Enantiopure 2-Aryl-2-Methyl Cyclopentanones by an Asymmetric Chelation-Controlled Heck Reaction Using Aryl Bromides: Increased Preparative Scope and Effect of Ring Size on Reactivity and Selectivity

Datta, Gopal K.; Nordeman, Patrik; Dackenberg, Jakob; Nilsson, Peter et al.

Ingår i Tetrahedron, s. 1120-1126, 2008

• DOI för Enantiopure 2-Aryl-2-Methyl Cyclopentanones by an Asymmetric Chelation-Controlled Heck Reaction Using Aryl Bromides: Increased Preparative Scope and Effect of Ring Size on Reactivity and Selectivity

A mechanistic study on modern palladium catalyst precursors as new gateways to Pd(0) in cationic Heck reactions

Svennebring, Andreas; Sjöberg, Per; Larhed, Mats; Nilsson, Peter

Ingår i Tetrahedron, s. 1808-1812, 2008

• DOI för A mechanistic study on modern palladium catalyst precursors as new gateways to Pd(0) in cationic Heck reactions

High Stereoselectivity in Chelation-Controlled Intermolecular Heck Reactions with Aryl Chlorides, Vinyl Chlorides and Vinyl Triflates

Datta, Gopal K.; Larhed, Mats

Ingår i Organic and biomolecular chemistry, s. 674-676, 2008

• DOI för High Stereoselectivity in Chelation-Controlled Intermolecular Heck Reactions with Aryl Chlorides, Vinyl Chlorides and Vinyl Triflates

Microwave-accelerated spiro-cyclizations of o-halobenzyl cyclohexenyl ethers by palladium(0) catalysis

Svennebring, Andreas; Nilsson, Peter; Larhed, Mats

Ingår i Journal of Organic Chemistry, s. 5851-5854, 2007

• DOI för Microwave-accelerated spiro-cyclizations of o-halobenzyl cyclohexenyl ethers by palladium(0) catalysis

Efficient palladium(II) catalysis under air. Base-free oxidative heck reactions at room temperature or with microwave heating

Lindh, Jonas; Enquist, Per-Anders; Pilotti, Åke; Nilsson, Peter et al.

Ingår i Journal of Organic Chemistry, s. 7957-7962, 2007

• DOI för Efficient palladium(II) catalysis under air. Base-free oxidative heck reactions at room temperature or with microwave heating

Synthesis of a new class of druglike angiotensin II C-terminal mimics with affinity for the AT2 receptor

Georgsson, Jennie; Sköld, Christian; Botros, Milad; Lindeberg, Gunnar et al.

Ingår i Journal of Medicinal Chemistry, s. 1711-1715, 2007

• DOI för Synthesis of a new class of druglike angiotensin II C-terminal mimics with affinity for the AT2 receptor

Microwave-enhanced alpha-arylation of a protected glycine in water: evaluation of 3-phenylglycine derivatives as inhibitors of the tuberculosis enzyme, glutamine synthetase

Lagerlund, Olof; Odell, Luke R.; Mowbray, Sherry L.; Nilsson, Mikael T. et al.

Ingår i Combinatorial chemistry & high throughput screening, s. 783-789, 2007

• DOI för Microwave-enhanced alpha-arylation of a protected glycine in water: evaluation of 3-phenylglycine derivatives as inhibitors of the tuberculosis enzyme, glutamine synthetase

Highly regioselective internal heck arylation of hydroxyalkyl vinyl ethers by aryl halides in water

Arvela, Riina K.; Pasquini, Serena; Larhed, Mats

Ingår i Journal of Organic Chemistry, s. 6390-6396, 2007

• DOI för Highly regioselective internal heck arylation of hydroxyalkyl vinyl ethers by aryl halides in water

Microwave-Enhanced Copper-Catalyzed N-Arylation of Free and Protected Amino Acids in Water

Röttger, Svenja; Sjöberg, Per J. R.; Larhed, Mats

Ingår i Journal of combinatorial chemistry, s. 204-209, 2007

• DOI för Microwave-Enhanced Copper-Catalyzed N-Arylation of Free and Protected Amino Acids in Water

ESI-MS Detection of Proposed Reaction Intermediates in the Air-Promoted and Ligand-Modulated Oxidative Heck Reaction

Enquist, Per-Anders; Nilsson, Peter; Sjöberg, Per; Larhed, Mats

Ingår i Journal of Organic Chemistry, s. 8779-8786, 2006

• DOI för ESI-MS Detection of Proposed Reaction Intermediates in the Air-Promoted and Ligand-Modulated Oxidative Heck Reaction

Variations of the P2 Group in HIV-1 Protease Inhibitors Containing a Tertiary Alcohol in the Transition-State Mimicking Scaffold

Ekegren, Jenny; Gising, Johan; Wallberg, Hans; Larhed, Mats et al.

Ingår i Organic and biomolecular chemistry, s. 3040-3043, 2006

• DOI för Variations of the P2 Group in HIV-1 Protease Inhibitors Containing a Tertiary Alcohol in the Transition-State Mimicking Scaffold

Microwave-accelerated synthesis of P1'-extended HIV-1 protease inhibitors encompassing a tertiary alcohol in the transition-state mimicking scaffold

Ekegren, Jenny K; Ginman, Nina; Johansson, Åsa; Wallberg, Hans et al.

Ingår i Journal of Medicinal Chemistry, s. 1828-1832, 2006

• DOI för Microwave-accelerated synthesis of P1'-extended HIV-1 protease inhibitors encompassing a tertiary alcohol in the transition-state mimicking scaffold

A New Structural Theme in C2-Symmetric HIV-1 Protease Inhibitors: ortho-Substituted P1/P1’ Side Chains

Wannberg, Johan; Sabnis, Yogesh A.; Vrang, Lotta; Samuelsson, Bertil et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 5303-5315, 2006

Stereoselective Synthesis of 3-Aminoindan-1-ones and Subsequent Incorporation into HIV-1 Protease Inhibitors

Arefalk, Anna; Wannberg, Johan; Larhed, Mats; Hallberg, Anders

Ingår i Journal of Organic Chemistry, s. 1265-1268, 2006

Open-air oxidative Heck reactions at room temperature

Enquist, Per-Anders; Lindh, Jonas; Nilsson, Peter; Larhed, Mats

Ingår i Green Chemistry, s. 338-343, 2006

• DOI för Open-air oxidative Heck reactions at room temperature

Selective Terminal Heck Arylation of Vinyl Ethers with Aryl Chlorides: A Combined Experimental-Computational Approach Including Synthesis of Betaxolol

Datta, Gopal K.; Schenck, Henrik von; Hallberg, Anders; Larhed, Mats

Ingår i Journal of Organic Chemistry, s. 3896-3903, 2006

Microwave-Promoted Aminocarbonylation of Aryl Iodides, Aryl Bromides, and Aryl Chlorides in Water

Wu, Xiongyu; Ekegren, Jenny; Larhed, Mats

Ingår i Organometallics, s. 1434-1439, 2006

Microwave-Accelerated Synthesis of P1´-Extended HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol in the Transition-State Mimicking Scaffold

Ekegren, Jenny; Ginman, Nina; Johansson, Åsa; Wallberg, Hans et al.

Ingår i Jounal of Medicinal Chemistry, s. 1828-1832, 2006

Selective terminal heck arylation of vinyl ethers with aryl chlorides: a combined experimental-computational approach including synthesis of betaxolol.

Datta, Gopal K; von Schenck, Henrik; Hallberg, Anders; Larhed, Mats

Ingår i J Org Chem, s. 3896-903, 2006

Hydroxylamine as an ammonia equivalent in microwave-enhanced aminocarbonylations

Wu, Xiongyu; Wannberg, Johan; Larhed, Mats

Ingår i Tetrahedron, s. 4665-4670, 2006

Microwave-promoted aminocarbonylation of aryl iodides, aryl bromides and aryl chlorides in water.

Wu, X; Ekegren, J K; Larhed, Mats

Ingår i Organometallics, s. 1434-1832, 2006

Microwave-assisted and metal-catalyzed coupling reactions

Nilsson, Peter; Olofsson, K; Larhed, Mats

Ingår i Top. Curr. Chem., s. 103-144, 2006

Microwave-accelerated synthesis of protease inhibitors

Wannberg, Johan; Ersmark, Karolina; Larhed, Mats

Ingår i Top. Curr. Chem., s. 3040-3043, 2006

Fast and selective synthesis of novel cyclic sulfamide HIV-1 purchase inhibitors under controlled microwave heating

Gold, H; Ax, A; Vrang, L; Samuelsson, B et al.

Ingår i Tetrahedron, s. 4671-4675, 2006

Microwave Irradiation as a High-Speed Toll for Activation of Sluggish Aryl Chlorides in Grignard Reactions

Gold, Henrik; Larhed, Mats; Nilsson, Peter

Ingår i Synlett, s. 1596-1600, 2005

Microwave-Enhanced and Metal-Catalyzed Functionalizations of the 4-Aryl-Dihydropyrimidone Template

Wannberg, Johan; Dallinger, Doris; Kappe, C. Oliver; Larhed, Mats

Ingår i Journal of combinatorial chemistry, s. 574-583, 2005

Super fast cobalt carbonyl-mediated synthesis of ureas

Enquist, Per-Anders; Nilsson, Peter; Edin, Johan; Larhed, Mats

Ingår i Tetrahedron Letters, s. 3335-3339, 2005

A One-Pot Isomerization-Arylation of 2,3-Epoxycyclohexanone under Controlled Microwave Heating

Svennebring, Andreas; Garg, Neeraj; Nilsson, Peter; Hallberg, Anders et al.

Ingår i The Journal of Organic Chemistry, s. 4720-4725, 2005

Easy-to-Execute Carbonylations: Microwave Synthesis of Acyl Sulfonamides Using Mo(CO)6 as a Solid Carbon Monoxide Source

Wu, Xiongyu; Rönn, Robert; Gossas, Thomas; Larhed, Mats

Ingår i The Journal of Organic Chemistry, s. 3094-3098, 2005

Masked 3-Aminoindan-1-ones by a Palladium-Catalyzed Three-Component Annulation Reaction

Arefalk, Anna; Larhed, Mats; Hallberg, Anders

Ingår i Journal of Organic Chemistry, s. 938-942, 2005

Microwave-enhanced aminocarbonylations in water.

Wu, Xiongyu; Larhed, Mats

Ingår i Org Lett, s. 3327-9, 2005

Easy-to-execute carbonylations: microwave synthesis of acyl sulfonamides using Mo(CO)(6) as a solid carbon monoxide source.

Wu, Xiongyu; Rönn, Robert; Gossas, Thomas; Larhed, Mats

Ingår i J Org Chem, s. 3094-8, 2005

Microwave-enhanced carbonylative generation of indanones and 3-acylaminoindanones.

Wu, Xiongyu; Nilsson, Peter; Larhed, Mats

Ingår i J Org Chem, s. 346-9, 2005

All the rave in microwaves.

Kappe, C Oliver; Larhed, Mats

Ingår i Angew Chem Int Ed Engl, s. 7666-9, 2005

Microwave-promoted aminocarbonylations of aryl chlorides using Mo(CO)(6) as a solid carbon monoxide source.

Lagerlund, Olof; Larhed, Mats

Ingår i J Comb Chem, s. 4-6, 2005

Super fast cobalt carbonyl-mediated synthesis of ureas compounds

Enquist, Per-Anders; Johan, Edin; Nilsson, Peter; Larhed, Mats

Ingår i Tetrahedron Letters, s. 3335-3339, 2005

Masked 3-aminoindan-1-ones by a palladium-catalyzed three-component annulation reaction.

Arefalk, Anna; Larhed, Mats; Hallberg, Anders

Ingår i J Org Chem, s. 938-42, 2005

A one-pot isomerization-arylation of 2,3-epoxycyclohexanone under controlled microwave heating.

Svennebring, Andreas; Garg, Neeraj; Nilsson, Peter; Hallberg, Anders et al.

Ingår i J Org Chem, s. 4720-5, 2005

The first ligand-modulated oxidative Heck vinylation. Efficient catalysis with molecular oxygen as palladium(0) oxidant

Andappan, Murugaiah M S; Nilsson, Peter; Larhed, Mats

Ingår i Chemical Communications, s. 218-9, 2004

An efficient method to perform milliliter-scale PCR utilizing highly controlled microwave thermocycling

Orrling, Kristina; Nilsson, Peter; Gullberg, Mats; Larhed, Mats

Ingår i Chemical Communications, s. 790-791, 2004

• DOI för An efficient method to perform milliliter-scale PCR utilizing highly controlled microwave thermocycling

Direct Microwave Synthesis of N,N'-diacylhydrazines and Boc-protected Hydrazides by in situ Carbonylations under Air

Herrero, Maria Antonia; Wannberg, Johan; Larhed, Mats

Ingår i Synlett, s. 2335-2338, 2004

Microwave-Promoted and Chelation-Controlled Double Arylation of Terminal Olefinic Carbon of Vinyl Ethers.

Svennebring, Andreas; Nilsson, Peter; Larhed, Mats

Ingår i The Journal of Organic Chemistry, s. 3345-3349, 2004

Microwave-enhanced medicinal chemistry: a high-speed opportunity for convenient preparation of protease inhibitors.

Ersmark, Karolina; Larhed, Mats; Wannberg, Johan

Ingår i Curr Opin Drug Discov Devel, s. 417-27, 2004

An efficient method to perform milliliter-scale PCR utilizing highly controlled microwave thermocycling.

Orrling, Kristina; Nilsson, Peter; Gullberg, Mats; Larhed, Mats

Ingår i Chem Commun (Camb), s. 790-1, 2004

Dioxygen-promoted regioselective oxidative heck arylations of electron-rich olefins with arylboronic acids.

Andappan, Murugaiah M S; Nilsson, Peter; von Schenck, Henrik; Larhed, Mats

Ingår i J Org Chem, s. 5212-8, 2004

Direct microwave synthesis of N,N'-diacylhydrazines and Boc-protected hydrazides by in situ carbonylations under air.

Herrero, Maria Antonia; Wannberg, Johan; Larhed, Mats

Ingår i Synlett, s. 2335-2338, 2004

Terminal Heck vinylations of chelating vinyl ethers.

Stadler, Alexander; von Schenck, Henrik; Vallin, Karl; Larhed, Mats et al.

Ingår i Advanced Synthesis & Catalysis, s. 1773-1781, 2004

Microwave-promoted and chelation-controlled double arylations of terminal olefinic carbon of vinyl ethers.

Svennebring, Andreas; Nilsson, Peter; Larhed, Mats

Ingår i J Org Chem, s. 3345-9, 2004

High-speed optimization of inhibitors of the malarial proteases plasmepsin I and II

Nöteberg, Daniel; Schaal, Wesley; Hamelink, Elizabeth; Vrang, Lotta et al.

Ingår i Journal of combinatorial chemistry, s. 456-464, 2003

• DOI för High-speed optimization of inhibitors of the malarial proteases plasmepsin I and II

Arylboronic acids as versatile coupling partners in fast microwave promoted oxidative Heck chemistry

Andappan, Murugaiah; Nilsson, Peter; Larhed, Mats

Ingår i Molecular diversity, s. 97-106, 2003

• DOI för Arylboronic acids as versatile coupling partners in fast microwave promoted oxidative Heck chemistry

Increasing Rates and Scope of Reactions: Sluggish Amines in Microwave-Heated Aminocarbonylation Reactions under Air

Wannberg, Johan; Larhed, Mats

Ingår i Journal of Organic Chemistry, s. 5750-5753, 2003

• DOI för Increasing Rates and Scope of Reactions: Sluggish Amines in Microwave-Heated Aminocarbonylation Reactions under Air

Rapid palladium-catalyzed synthesis of esters from aryl halides utilizing Mo(CO)6 as a solid carbon monoxide source

Georgsson, Jennie; Hallberg, Anders; Larhed, Mats

Ingår i Journal of Combinatorial Chemistry, s. 350-352, 2003

Ultrafast Chemistry: Cobalt Carbonyl-Mediated Synthesis of Diaryl Ketones under Microwave Irradiation

Enquist, Per-Anders; Nilsson, Peter; Larhed, Mats

Ingår i Organic Letters, s. 4875-4878, 2003

Microwave-assisted high-speed PCR

Fermér, Christian; Nilsson, Peter; Larhed, Mats

Ingår i European Journal of Pharmaceutical Sciences, s. 129-132, 2003

A Rapid Microwave Protocol for Heck Vinylation of Aryl Chlorides under Air

Datta, Gopal K.; Vallin, Karl S. A.; Larhed, Mats

Ingår i Molecular Diversity, s. 107-114, 2003

A New Highly Asymmetric Chelation-Controlled Heck Arylation

Nilsson, Peter; Larhed, Mats; Hallberg, Anders

Ingår i Journal of the American Chemical Society, s. 3430-3431, 2003

A rapid microwave protocol for Heck vinylation of aryl chlorides under air.

Datta, GK; Vallin, KS; Larhed, M

Ingår i Mol Divers, s. 107, 2003

Microwave-Assisted Enantioselective Heck Reactions: Expediting High Reaction Speed and Preparative Convenience

Nilsson, Peter; Gold, Henrik; Larhed, Mats; Hallberg, Anders

Ingår i Synthesis, s. 1611-1614, 2002

High-Speed Heck Reactions in Ionic Liquid with Controlled Microwave Heating

Vallin, Karl S. A.; Emilsson, Per; Larhed, Mats; Hallberg, Anders

Ingår i J. Org. Chem., s. 6243-6246, 2002

Protected Indanones by a Heck-Aldol Annulation Reaction

Bengtson, Anna; Larhed, Mats; Hallberg, Anders

Ingår i Journal of Organic Chemistry, s. 5854-5856, 2002

Fast Synthesis of Aryl Triflates with Controlled Microwave Heating

Bengtson, Anna; Hallberg, Anders; Larhed, Mats

Ingår i Organic Letters, s. 1231-1233, 2002

Aqueous DMF-Potassium Carbonate as a Substitute for Thallium and Silver Additives in the Palladium-Catalyzed Conversion of Aryl Bromides to Acetyl Arenes

Vallin, Karl S. A.; Larhed, Mats; Hallberg, Anders

Ingår i J. Org. Chem., s. 4340-4343, 2001

Highly Regioselective, Sequential and Multiple Palladium-Catalyzed Arylations of Vinyl Ethers Carrying a Coordinating Auxiliary: An Example of a Heck Triarylation Process

Nilsson, Peter; Larhed, Mats; Hallberg, Anders

Ingår i Journal of the American Chemical Society, s. 8217-8225, 2001

Highly Selective Palladium-Catalyzed Synthesis of Protected a,ß-Unsaturated Methyl Ketones and 2-Alkoxy-1,3-Butadienes: High-Speed Chemistry by Microwave Flash Heating

Vallin, Karl S. A.; Larhed, Mats; Johansson, Katarina; Hallberg, Anders

Ingår i J. Org. Chem., s. 4537-4542, 2000

New Regioselective Heck-Vinylation with Enamides. Synthesis and Investigation of Fluorous Tagged Bidentate Ligands for Fast Separation

Vallin, Karl S. A.; Zhang, Qisheng; Larhed, Mats; Curran, Dennis P. et al.

Ingår i J. Org. Chem.

From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase

Hallberg, Mathias; Larhed, Mats

Ingår i Frontiers in Pharmacology, 2020

• DOI för From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase
• Ladda ner fulltext (pdf) av From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase

Aspartic protease inhibitors containing tertiary alcohol transition-state mimics

Motwani, Hitesh V.; De Rosa, Maria; Odell, Luke R.; Hallberg, Anders et al.

Ingår i European Journal of Medicinal Chemistry, s. 462-490, 2014

• DOI för Aspartic protease inhibitors containing tertiary alcohol transition-state mimics

Syntheses of new tuberculosis inhibitors promoted by microwave irradiation

De Rosa, Maria; Gising, Johan; Odell, Luke R; Larhed, Mats

Ingår i Upsala Journal of Medical Sciences, s. 181-191, 2014

• DOI för Syntheses of new tuberculosis inhibitors promoted by microwave irradiation

Controlled microwave heating as an enabling technology: Expedient synthesis of protease inhibitors in perspective

Larhed, Mats; Wannberg, Johan; Hallberg, Anders

Ingår i QSAR & combinatorial science (Print), s. 51-68, 2007

• DOI för Controlled microwave heating as an enabling technology: Expedient synthesis of protease inhibitors in perspective

Microwave-assisted synthesis of anti-tuberculosis, HIV and hepatitis C agents

Gising, Johan; Larhed, Mats; Odell, Luke R

Ingår i Microwaves in Drug Discovery and Development, s. 34-54, Future Medicine, 2014

• DOI för Microwave-assisted synthesis of anti-tuberculosis, HIV and hepatitis C agents

Microwave-Heated Transition Metal-Catalyzed Coupling Reactions

Russo, Francesco; Odell, Luke R; Olofsson, Kristofer; Nilsson, Peter et al.

Ingår i Microwaves in Organic Synthesis, s. 607-672, Wiley-VCH Verlagsgesellschaft, 2012

Microwave-Assisted Transition Metal-Catalyzed Asymmetric Synthesis

Odell, Luke R; Larhed, Mats

Ingår i Catalytic Methods in Asymmetric Synthesis, s. 391-412, Wiley-Blackwell, 2011

• DOI för Microwave-Assisted Transition Metal-Catalyzed Asymmetric Synthesis

Microwave-accelerated homogenous catalysis in water

Odell, Luke R; Larhed, Mats

Ingår i Handbook of green chemistry, s. 79-99, Wiley-VCH Verlagsgesellschaft, 2009

Focus on Regioselectivity and Product Outcome in Organic Synthesis

Nilsson, Peter; Olofsson, Kristofer; Larhed, Mats

Ingår i The Mizoroki-Heck Reaction, s. 133-162, John Wiley & Sons, 2009

• DOI för Focus on Regioselectivity and Product Outcome in Organic Synthesis

Accelerated Chemistry: Microwave, Sonochemical, and Fluorous Phase Techniques

Olofsson, Kristoffer; Nilsson, Peter; Larhed, Mats

Ingår i Exploiting chemical diversity for drug discovery, s. 33-48, Royal Chemical Society, 2006

• DOI för Accelerated Chemistry: Microwave, Sonochemical, and Fluorous Phase Techniques

Microwave Accelerated Metal Catalysis: Organic Transformations at Warp Speed

Olofsson, Kristoffer; Larhed, Mats

Ingår i Microwave Assisted Organic Synthesis, s. 25-43, Blackwell publishing, 2005

Microwave-Assisted Fluorous Chemistry

Olofsson, Kristoffer; Larhed, Mats

Ingår i Handbook of Fluorous Chemistry, s. 359-365, Wiley-VCH, 2004

Palladium-Catalyzed Multiple and Asymmetric Arylations of Vinyl Ethers Carrying Coordinating Nitrogen Auxiliaries: Synthesis of Arylated Ketones and Aldehydes

Nilsson, Peter; Larhed, Mats

Ingår i Catalysts for the Fine Chemical Synthesis, Vol. 3, s. 92-99, John Wiley and Sons, 2004

Transition metal-catalysis and microwave flash-heating in organic chemistry

Olofsson, Kristofer; Hallberg, Anders; Larhed, Mats

Ingår i Microwaves in Organic Synthesis, Wiley-VCH, 2002

• DOI för Transition metal-catalysis and microwave flash-heating in organic chemistry

Scope, Mechanism and Other Fundamental Aspects of the Intermolecular Heck Reaction

Larhed, M; Hallberg, A

Ingår i Handbook of Organopalladium Chemistry for Organic Synthesis, Wiley-Interscience, 2002

Experimental Techniques in Fluorous Synthesis: A users guide

Curran, D P; Hadida, S; Studer, A; He, M et al.

Ingår i Combinatorial Chemistry, s. 338-340, 2000

Synthesis and initial preclinical evaluation of the CRTH2 antagonist [C-11] MK-7246

Eriksson, Jonas; Roy, Tamal; Sawadjoon, Supaporn; Bachmann, Kim et al.

Ingår i Journal of Labelled Compounds and Pharmaceuticals, 2019

Theoretical Mechanistic Investigation of a Decarboxylative Heck Reaction with an Electron-Rich Olefin and Possible Catalyst Entrapment by the Heck Product

Fardost, Ashkan; Svensson, Fredrik; Larhed, Mats; Sköld, Christian

Non-peptide AT2-receptor agonists

Larhed, Mats; Hallberg, Mathias; Hallberg, Anders

Ingår i Medicinal Chemistry Reviews, 2016