Maia lab
We pursue new ways to explore the wonderfully complex world of structural dynamics at the nanoscale. We are focused on the development of lensless imaging methods using X-rays, making use of X-ray free-electron lasers as a powerful coherent light source.A common theme across many modern imaging techniques is the increasing complexity of the experimental setups. as well as the data analysis. Our lab focuses on both building new instrumentation, such as container free sample delivery for X-ray single particle imaging experiments, as well as creating the algorithms for analysing the resulting data. This co-design of all parts of the experiment is crucial to the success and requires a wide range of expertise, from biology to physicis and computer science, resulting in a highly collaborative and cross-disciplinary environment.
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Research
We make use of cutting-edge technological developments, such as X-rays free-electron lasers, 4th generation sycnhrotrons and the massive computing power brought about by GPUs to advance X-ray lensless imaging methods. Our projects span X-ray single particle diffractive imaging, fluctuation X-ray scattering and ptychography. For more information please click on the link below.
Publications
Part of Journal of the American Chemical Society, p. 19555-19565, 2024
Observation of a single protein by ultrafast X-ray diffraction
Part of Light, 2024
3D-printed sheet jet for stable megahertz liquid sample delivery at X-ray free-electron lasers
Part of IUCrJ, p. 662-670, 2023
Noise reduction and mask removal neural network for X-ray single-particle imaging
Part of Journal of applied crystallography, p. 122-132, 2022
Part of IUCrJ, p. 204-214, 2022
3D diffractive imaging of nanoparticle ensembles using an x-ray laser
Part of Optica, p. 15-23, 2021
Introduction to the special issue on Ptychography: software and technical developments
Part of Journal of applied crystallography, p. 384-385, 2021
Ptychographic wavefront characterization for single-particle imaging at x-ray lasers
Part of Optica, p. 551-562, 2021
Acquired Functional Capsid Structures in Metazoan Totivirus-like dsRNA Virus
Part of Structure, p. 888-+, 2020
Part of Scientific Data, 2020
Megahertz single-particle imaging at the European XFEL
Part of Communications Physics, 2020
Part of Structural Dynamics, 2020
Pulse-to-pulse wavefront sensing at free-electron lasers using ptychography
Part of Journal of applied crystallography, p. 949-956, 2020
The role of transient resonances for ultra-fast imaging of single sucrose nanoclusters
Part of Nature Communications, 2020
Three-Dimensional Coherent Bragg Imaging of Rotating Nanoparticles
Part of Physical Review Letters, 2020
Electrospray sample injection for single-particle imaging with x-ray lasers
Part of Science Advances, 2019
Evaluation of serial crystallographic structure determination within megahertz pulse trains
Part of Structural Dynamics, 2019
A statistical approach to detect protein complexes at X-ray free electron laser facilities
Part of Communications Physics, 2018
Part of Nature Scientific Data, 2018
Part of IUCrJ, p. 531-541, 2018
Cryo-EM structure of a Marseilleviridae virus particle reveals a large internal microassembly
Part of Virology, p. 239-245, 2018
Femtosecond X-ray Fourier holography imaging of free-flying nanoparticles
Part of Nature Photonics, p. 150-153, 2018
Megahertz serial crystallography
Part of Nature Communications, 2018
Rayleigh-scattering microscopy for tracking and sizing nanoparticles in focused aerosol beams
Part of IUCrJ, p. 673-680, 2018
Single-particle imaging without symmetry constraints at an X-ray free-electron laser
Part of IUCrJ, p. 727-736, 2018
Three-dimensional localization of nanoscale battery reactions using soft X-ray tomography
Part of Nature Communications, 2018
Coherent soft X-ray diffraction imaging of Coliphage PR772 at the Linac coherent light source
Part of Scientific Data, 2017
Correlations in scattered X-ray laser pulses reveal nanoscale structural features of viruses
Part of Physical Review Letters, 2017
Experimental strategies for imaging bioparticles with femtosecond hard X-ray pulses
Part of IUCrJ, p. 251-262, 2017
Nanosurveyor: a framework for real-time data processing
Part of Advanced Structural and Chemical Imaging, 2017
Near-edge X-ray refraction fine structure microscopy
Part of Applied Physics Letters, 2017
Part of Scientific Reports, 2017
- DOI for Structural variability and complexity of the giant Pithovirus sibericum particle revealed by high-voltage electron cryo-tomography and energy-filtered electron cryo-microscopy
- Download full text (pdf) of Structural variability and complexity of the giant Pithovirus sibericum particle revealed by high-voltage electron cryo-tomography and energy-filtered electron cryo-microscopy
A data set from flash X-ray imaging of carboxysomes
Part of Scientific Data, 2016
CCP-FEL: a collection of computer programs for free-electron laser research
Part of Journal of applied crystallography, p. 1117-1120, 2016
Part of Scientific Data, 2016
Data publication with the structural biology data grid supports live analysis
Part of Nature Communications, 2016
Hummingbird: monitoring and analyzing flash X-ray imaging experiments in real time
Part of Journal of applied crystallography, p. 1042-1047, 2016
Open data set of live cyanobacterial cells imaged using an X-ray laser
Part of Scientific Data, 2016
SHARP: a distributed GPU-based ptychographic solver
Part of Journal of applied crystallography, p. 1245-1252, 2016
Single-shot diffraction data from the Mimivirus particle using an X-ray free-electron laser
Part of Scientific Data, 2016
Part of Scientific Reports, 2016
The trickle before the torrent-diffraction data from X-ray lasers
Part of Scientific Data, 2016
Imaging single cells in a beam of live cyanobacteria with an X-ray laser
Part of Nature Communications, 2015
The linac coherent light source single particle imaging road map
Part of Structural Dynamics, 2015
Three-dimensional reconstruction of the giant mimivirus particle with an X-ray free-electron laser
Part of Physical Review Letters, 2015
Part of Journal of applied crystallography, p. 1118-1131, 2014
Chemical composition mapping with nanometre resolution by soft X-ray microscopy
Part of Nature Photonics, p. 765-769, 2014
Part of Optics Express, p. 28914-28925, 2014
High-throughput imaging of heterogeneous cell organelles with an X-ray laser
Part of Nature Photonics, p. 943-949, 2014
Shapes and vorticities of superfluid helium nanodroplets
Part of Science, p. 906-909, 2014