Michal Maj group
Ultrafast multidimensional laser spectroscopic techniques and structural biological methods to obtain answers to fundamental questions in chemistry and biophysics.
About the Michal Maj group
Within the research in our group we apply ultrafast multidimensional laser spectroscopic techniques and structural biology methods, such as cryogenic electron microscopy, in search for answers to fundamental questions in chemistry and biophysics.
More information
Find out more about us on our external website: www.majgroup.net
Our research
The structure and function of molecules are largely determined by the way their chemical bonds move and interact with each other. Chemical bonds are dynamic entities, exhibiting collective structural changes on timescales as short as a trillionth of a second.
The ultrashort pulsed lasers used in our laboratory are designed to observe such fast events, both under equilibrium conditions and following an instantaneous external perturbation. Our research interests are diverse, covering a wide spectrum of topics at both the molecular and cellular levels, with a keen focus on understanding both the structure and dynamics of the studied molecules.
Gruppmedlemmar
Publications
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Exploring Excited State Proton Transfer Dynamics upon Ultraviolet Excitation
Part of Journal of Physical Chemistry A, p. 2566-2574, 2026
- DOI for Exploring Excited State Proton Transfer Dynamics upon Ultraviolet Excitation
- Download full text (pdf) of Exploring Excited State Proton Transfer Dynamics upon Ultraviolet Excitation
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Part of Journal of Chemical Physics, 2026
- DOI for Two-dimensional infrared spectroscopy of solute-solvent complexes from linear-scaling DFT and machine learning
- Download full text (pdf) of Two-dimensional infrared spectroscopy of solute-solvent complexes from linear-scaling DFT and machine learning
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A Highly Sensitive Water-Soluble Donor-Acceptor Dye for Early-Stage Amyloid Aggregation Kinetics
Part of Journal of Physical Chemistry B, p. 3042-3053, 2026
- DOI for A Highly Sensitive Water-Soluble Donor-Acceptor Dye for Early-Stage Amyloid Aggregation Kinetics
- Download full text (pdf) of A Highly Sensitive Water-Soluble Donor-Acceptor Dye for Early-Stage Amyloid Aggregation Kinetics
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Part of RSC Chemical Biology, p. 38-43, 2026
- DOI for High-resolution structure of proIAPP(1–48) fibrils suggests a mechanistic pathway for diabetes-associated IAPP fibril polymorphs
- Download full text (pdf) of High-resolution structure of proIAPP(1–48) fibrils suggests a mechanistic pathway for diabetes-associated IAPP fibril polymorphs
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Part of Journal of the American Chemical Society, p. 45701-45711, 2025
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Part of Journal of Chemical Physics, 2025
- DOI for Solvatochromic charge model of isonitrile probes for investigating hydrogen-bond dynamics with 2DIR spectroscopy
- Download full text (pdf) of Solvatochromic charge model of isonitrile probes for investigating hydrogen-bond dynamics with 2DIR spectroscopy
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Part of Communications Chemistry, 2025
- DOI for Observation of early events in the photoactivation of Myxobacterial phytochrome using time-resolved serial femtosecond crystallography
- Download full text (pdf) of Observation of early events in the photoactivation of Myxobacterial phytochrome using time-resolved serial femtosecond crystallography
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Part of Journal of Molecular Biology, 2025
- DOI for Cryo-EM exposes diverse polymorphism in IAPP mutants to guide the rational design of peptide-based therapeutics
- Download full text (pdf) of Cryo-EM exposes diverse polymorphism in IAPP mutants to guide the rational design of peptide-based therapeutics
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Part of Physical Chemistry, Chemical Physics - PCCP, p. 20279-20287, 2025
- DOI for Detection of a hybrid PrPfr state in the dark reversion of a bathy phytochrome indicates inter-dimer allostery
- Download full text (pdf) of Detection of a hybrid PrPfr state in the dark reversion of a bathy phytochrome indicates inter-dimer allostery
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Part of Biochemistry, p. 2583-2595, 2025
- DOI for Cryo-Electron Microscopy Provides Mechanistic Insights into Solution-Dependent Polymorphism and Cross-Aggregation Phenomena of the Human and Rat Islet Amyloid Polypeptides
- Download full text (pdf) of Cryo-Electron Microscopy Provides Mechanistic Insights into Solution-Dependent Polymorphism and Cross-Aggregation Phenomena of the Human and Rat Islet Amyloid Polypeptides
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Part of Nature Chemistry, p. 624-632, 2024
- DOI for Directed ultrafast conformational changes accompany electron transfer in a photolyase as resolved by serial crystallography
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Improving cryo-EM grids for amyloid fibrils using interface-active solutions and spectator proteins
Part of Biophysical Journal, p. 718-729, 2024
- DOI for Improving cryo-EM grids for amyloid fibrils using interface-active solutions and spectator proteins
- Download full text (pdf) of Improving cryo-EM grids for amyloid fibrils using interface-active solutions and spectator proteins
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Protein cohabitation: long-term immunoglobulin G storage at room temperature
Part of Journal of materials chemistry. B, p. 5400-5405, 2023
- DOI for Protein cohabitation: long-term immunoglobulin G storage at room temperature
- Download full text (pdf) of Protein cohabitation: long-term immunoglobulin G storage at room temperature
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Part of Journal of Chemical Physics, 2023
- DOI for Ground-state heterogeneity and vibrational energy redistribution in bacterial phytochrome observed with femtosecond 2D IR spectroscopy
- Download full text (pdf) of Ground-state heterogeneity and vibrational energy redistribution in bacterial phytochrome observed with femtosecond 2D IR spectroscopy
Contact
- If you have any questions regarding our research, you are welcome to contact Michal Maj.
- Michal Maj