Lars Forsberg – LOY – why men live shorter lives?

Loss of Y Chromosome and Major Cardiovascular Events in a Prospective Study of Older Men

Hussain, Sultana Monira; Bjurling, Josefin; Yu, Chenglong; Tonkin, Andrew M. et al.

Part of Journal of the American College of Cardiology, p. 36-45, 2026

• DOI for Loss of Y Chromosome and Major Cardiovascular Events in a Prospective Study of Older Men

Hematopoietic loss of Y chromosome activates immune checkpoints and contributes to impaired senescent cell clearance and renal disease

Arai, Yohei; Chavkin, Nicholas W.; Arai, Yuka; Halvardson, Jonatan et al.

Part of Science Translational Medicine, 2025

• DOI for Hematopoietic loss of Y chromosome activates immune checkpoints and contributes to impaired senescent cell clearance and renal disease

Mosaic loss of chromosome Y in blood is associated with male susceptibility for idiopathic pulmonary fibrosis

Bjurling, Josefin; Chavkin, Nicholas W.; Halvardson, Jonatan; Thel, Mark C. et al.

Part of Communications Medicine, 2025

• DOI for Mosaic loss of chromosome Y in blood is associated with male susceptibility for idiopathic pulmonary fibrosis
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Loss of chromosome Y in regulatory T cells

Mattisson, Jonas; Halvardson, Jonatan; Davies, Hanna; Bruhn-Olszewska, Bozena et al.

Part of BMC Genomics, 2024

• DOI for Loss of chromosome Y in regulatory T cells
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Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality

Sano, Soichi; Horitani, Keita; Ogawa, Hayato; Halvardson, Jonatan et al.

Part of Science, p. 292-297, 2022

• DOI for Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality

Loss of Y and clonal hematopoiesis in blood: two sides of the same coin?

Ljungström, Viktor; Mattisson, Jonas; Halvardson, Jonatan; Pandzic, Tatjana et al.

Part of Leukemia, p. 889-891, 2022

• DOI for Loss of Y and clonal hematopoiesis in blood: two sides of the same coin?
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Reply to Guo's commentary on: "Immune cells lacking Y chromosome show dysregulation of autosomal gene expression"

Forsberg, Lars A.

Part of Cellular and Molecular Life Sciences (CMLS), 2022

• DOI for Reply to Guo's commentary on: "Immune cells lacking Y chromosome show dysregulation of autosomal gene expression"
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A polygenic risk score predicts mosaic loss of chromosome Y in circulating blood cells

Riaz, Moeen; Mattisson, Jonas; Polekhina, Galina; Bakshi, Andrew et al.

Part of Cell & Bioscience, 2021

• DOI for A polygenic risk score predicts mosaic loss of chromosome Y in circulating blood cells
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Chromosome Y loss and drivers of clonal hematopoiesis in myelodysplastic syndrome

Baliakas, Panagiotis; Forsberg, Lars A.

Part of Haematologica, p. 329-331, 2021

• DOI for Chromosome Y loss and drivers of clonal hematopoiesis in myelodysplastic syndrome
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Immune cells lacking Y chromosome show dysregulation of autosomal gene expression

Dumanski, Jan P.; Halvardson, Jonatan; Davies, Hanna; Rychlicka-Buniowska, Edyta et al.

Part of Cellular and Molecular Life Sciences (CMLS), p. 4019-4033, 2021

• DOI for Immune cells lacking Y chromosome show dysregulation of autosomal gene expression
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Leukocytes with chromosome Y loss have reduced abundance of the cell surface immunoprotein CD99

Mattisson, Jonas; Danielsson, Marcus; Hammond, Maria; Davies, Hanna et al.

Part of Scientific Reports, 2021

• DOI for Leukocytes with chromosome Y loss have reduced abundance of the cell surface immunoprotein CD99
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Reply to Veitia

Danielsson, Marcus; Halvardson, Jonatan; Mattisson, Jonas; Forsberg, Lars A.

Part of European Journal of Human Genetics, p. 1323-1324, 2021

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Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals

Danielsson, Marcus; Halvardson, Jonatan; Davies, Hanna; Moghadam, Behrooz Torabi et al.

Part of European Journal of Human Genetics, p. 349-357, 2020

• DOI for Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals
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Back to the drawing board: loss of chromosome Y (LOY) inleukocytes is associated with age-related macular degeneration

Forsberg, Lars A.

Part of European Journal of Human Genetics, p. 17-19, 2019

• DOI for Back to the drawing board: loss of chromosome Y (LOY) inleukocytes is associated with age-related macular degeneration
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Genetic predisposition to mosaic Y chromosome loss in blood

Thompson, Deborah J; Genovese, Giulio; Halvardson, Jonatan; Ulirsch, Jacob C et al.

Part of Nature, p. 652-657, 2019

• DOI for Genetic predisposition to mosaic Y chromosome loss in blood

Mosaic loss of chromosome Y in leukocytes matters

Forsberg, Lars A.; Halvardson, Jonatan; Rychlicka-Buniowska, Edyta; Danielsson, Marcus et al.

Part of Nature Genetics, p. 4-7, 2019

• DOI for Mosaic loss of chromosome Y in leukocytes matters

PRR14L mutations are associated with chromosome 22 acquired uniparental disomy, age-related clonal hematopoiesis and myeloid neoplasia

Chase, Andrew; Pellagatti, Andrea; Singh, Shalini; Score, Joannah et al.

Part of Leukemia, p. 1184-1194, 2019

• DOI for PRR14L mutations are associated with chromosome 22 acquired uniparental disomy, age-related clonal hematopoiesis and myeloid neoplasia

Self-reported sleep disturbances and prostate cancer morbidity and mortality in Swedish men: A longitudinal study over 40 years

Tan, Xiao; Cedernaes, Jonathan; Forsberg, Lars A.; Schiöth, Helgi B. et al.

Part of Journal of Sleep Research, 2018

• DOI for Self-reported sleep disturbances and prostate cancer morbidity and mortality in Swedish men: A longitudinal study over 40 years
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A MUTYH germline mutation is associated with small intestinal neuroendocrine tumors

Dumanski, Jan P.; Rasi, Chiara; Björklund, Peyman; Davies, Hanna et al.

Part of Endocrine-Related Cancer, p. 427-443, 2017

• DOI for A MUTYH germline mutation is associated with small intestinal neuroendocrine tumors
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Loss of Chromosome Y in Leukocytes and Major Cardiovascular Events

Dumanski, Jan P.; Sundström, Johan; Forsberg, Lars A.

Part of Circulation, 2017

• DOI for Loss of Chromosome Y in Leukocytes and Major Cardiovascular Events

Loss of chromosome Y (LOY) in blood cells is associated with increased risk for disease and mortality in aging men

Forsberg, Lars A.

Part of Human Genetics, p. 657-663, 2017

• DOI for Loss of chromosome Y (LOY) in blood cells is associated with increased risk for disease and mortality in aging men

Mosaicism in health and disease — clones picking up speed

Forsberg, Lars A.; Gisselsson, David; Dumanski, Jan P.

Part of Nature reviews genetics, p. 128-142, 2017

• DOI for Mosaicism in health and disease — clones picking up speed

Biobanking multifocal breast carcinomas: sample adequacy with regard to histology and DNA content

Pekar, Gyula; Davies, Hanna; Lukacs, Agnes P; Forsberg, Lars et al.

Part of Histopathology, p. 411-421, 2016

• DOI for Biobanking multifocal breast carcinomas: sample adequacy with regard to histology and DNA content

Human serum-derived protein removes the need for coating in defined human pluripotent stem cell culture

Pijuan-Galito, Sara; Tamm, Christoffer; Schuster, Jens; Sobol, Maria et al.

Part of Nature Communications, 2016

• DOI for Human serum-derived protein removes the need for coating in defined human pluripotent stem cell culture
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Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease

Dumanski, Jan P.; Lambert, Jean-Charles; Rasi, Chiara; Giedraitis, Vilmantas et al.

Part of American Journal of Human Genetics, p. 1208-1219, 2016

• DOI for Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease
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Concurrent DNA Copy-Number Alterations and Mutations in Genes Related to Maintenance of Genome Stability in Uninvolved Mammary Glandular Tissue from Breast Cancer Patients

Ronowicz, Anna; Janaszak-Jasiecka, Anna; Skokowski, Jaroslaw; Madanecki, Piotr et al.

Part of Human Mutation, p. 1088-1099, 2015

• DOI for Concurrent DNA Copy-Number Alterations and Mutations in Genes Related to Maintenance of Genome Stability in Uninvolved Mammary Glandular Tissue from Breast Cancer Patients

Detection of leukemia-associated mutations in peripheral blood DNA of hematologically normal elderly individuals

Score, J.; Chase, A.; Forsberg, Lars; Feng, L. et al.

Part of Leukemia, p. 1600-1602, 2015

• DOI for Detection of leukemia-associated mutations in peripheral blood DNA of hematologically normal elderly individuals

Mutagenesis: smoking is associated with mosaic loss of chromosome Y

Dumanski, Jan P.; Rasi, Chiara; Lönn, Mikael; Davies, Hanna et al.

Part of Science, p. 81-83, 2015

• DOI for Mutagenesis: smoking is associated with mosaic loss of chromosome Y

Profound parental bias associated with chromosome 14 acquired uniparental disomy indicates targeting of an imprinted locus

Chase, A.; Leung, W.; Tapper, W.; Jones, A. V. et al.

Part of Leukemia, p. 2069-2074, 2015

• DOI for Profound parental bias associated with chromosome 14 acquired uniparental disomy indicates targeting of an imprinted locus

Signatures of post-zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer

Forsberg, Lars A.; Rasi, Chiara; Pekar, Gyula; Davies, Hanna et al.

Part of Genome Research, p. 1521-1535, 2015

• DOI for Signatures of post-zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer
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Whole exome sequencing identifies LRP1 as a pathogenic gene in autosomal recessive keratosis pilaris atrophicans

Klar, Joakim; Schuster, Jens; Khan, Tahir Naeem; Jameel, Muhammad et al.

Part of Journal of Medical Genetics, p. 599-606, 2015

• DOI for Whole exome sequencing identifies LRP1 as a pathogenic gene in autosomal recessive keratosis pilaris atrophicans

Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer

Forsberg, Lars A.; Rasi, Chiara; Malmqvist, Niklas; Davies, Hanna et al.

Part of Nature Genetics, p. 624-628, 2014

• DOI for Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer

Non-heritable genetics of human disease: spotlight on post-zygotic genetic variation acquired during lifetime

Forsberg, Lars A.; Absher, Devin; Dumanski, Jan Piotr

Part of Journal of Medical Genetics, p. 1-10, 2013

• DOI for Non-heritable genetics of human disease: spotlight on post-zygotic genetic variation acquired during lifetime

Non-heritable genetics of human disease: spotlight on post-zygotic genetic variation acquired during lifetime (Reprinted from vol 50, pg 1-10, 2013)

Forsberg, Lars A.; Absher, Devin; Dumanski, Jan Piotr

Part of Postgraduate medical journal, p. 417-426, 2013

• DOI for Non-heritable genetics of human disease: spotlight on post-zygotic genetic variation acquired during lifetime (Reprinted from vol 50, pg 1-10, 2013)
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Post-Zygotic and Inter-Individual Structural Genetic Variation in a Presumptive Enhancer Element of the Locus between the IL10Rβ and IFNAR1 Genes

Razzaghian, Hamid Reza; Forsberg, Lars Anders; Prakash, Kancherla Reddy; Przerada, Szymon et al.

Part of PLOS ONE, 2013

• DOI for Post-Zygotic and Inter-Individual Structural Genetic Variation in a Presumptive Enhancer Element of the Locus between the IL10Rβ and IFNAR1 Genes
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Age-related somatic structural changes in the nuclear genome of human blood cells

Forsberg, Lars A.; Rasi, Chiara; Razzaghian, Hamid R; Pakalapati, Geeta et al.

Part of American Journal of Human Genetics, p. 217-228, 2012

• DOI for Age-related somatic structural changes in the nuclear genome of human blood cells

Somatic Mosaicism for Chromosome X and Y Aneuploidies in Monozygotic Twins Heterozygous for Sickle Cell Disease Mutation

Razzaghian, Hamid Reza; Shahi, Mehdi Hayat; Forsberg, Lars A.; Diaz de Ståhl, Teresita et al.

Part of American Journal of Medical Genetics. Part A, p. 2595-2598, 2010

• DOI for Somatic Mosaicism for Chromosome X and Y Aneuploidies in Monozygotic Twins Heterozygous for Sickle Cell Disease Mutation

Sperm competition between alternative reproductive tactics of the Atlantic salmon in vitro

Vladic, Tomislav; Forsberg, Lars A.; Järvi, Torbjörn

Part of Aquaculture, p. 265-269, 2010

• DOI for Sperm competition between alternative reproductive tactics of the Atlantic salmon in vitro

Influence of genetic dissimilarity in the reproductive success and mate choice of brown trout – females fishing for optimal MHC dissimilarity

Forsberg, Lars A.; Dannewitz, Johan; Petersson, Erik; Grahn, Mats

Part of Journal of Evolutionary Biology, p. 1859-1869, 2007

• DOI for Influence of genetic dissimilarity in the reproductive success and mate choice of brown trout – females fishing for optimal MHC dissimilarity