Finn Hallböök – Stem cells, retinal development and regeneration

Our research concerns how neurons in the retina of the eye are formed from stem cells and neuronal precursor cells. The goal is to understand what goes wrong in nerve cell formation when the retina cancer, retinoblastoma, develops in the eye. Our research also aims at harnessing the control of neuron formation towards either forming new neurons or becoming supportive glial cells in the event of injuries or diseases.

We use human embryonic stem cell (hESC)-derived model system where retina is formed in culture. These “mini-eyes”, also called retinal organoids, are 3-dimensional ex vivo tissue systems of human retina established after differentiation of hESCs. The hESCs are induced to form brain-neuroepithelium and via the prosencephalic eye-field, neural retina of the optic cup is formed.

Retinal organoids recapitulate formation of retinal structure and cells

The organoids form an organised tissue with all cell types in a laminated and functional structure. They recapitulate the development of normal human retina and are therefore a powerful and versatile model to study the development of human retina. The retinoids are also used to study and model retinoblastoma carcinogenesis with focus on the early events in the carcinogenesis. We also use well-studied animal models for the eye as a complement to the organoids and to develop new research questions and hypotheses.

Our research projects

Studies of neurogenesis in the vertebrate retina.
Studies of the early events during retinoblastoma carcinogenesis in the human hESC-derived model for retinal development.
Establishment of a stem cell derived human retina model and studies of human neurogenesis in vitro.
Studies of endogenous retinal stem- and progenitor cells. The dicotomy of retinal Müller cells: supporters of retinal homeostasis or a source for new neurons and eye growth.

Group members

Research leader: Finn Hallböök

Group members: Henrik Ring, Sowmya Senthil, Tatsiana Tararuk, Hanzhao Zhang

Publications

Inhibition of high level E2F in a RB1 proficient MYCN overexpressing chicken retinoblastoma model normalizes neoplastic behaviour

Zhang, Hanzhao; Konjusha, Dardan; Rafati, Nima; Tararuk, Tatsiana et al.

Part of Cellular Oncology, p. 209-227, 2024
- DOI for Inhibition of high level E2F in a RB1 proficient MYCN overexpressing chicken retinoblastoma model normalizes neoplastic behaviour
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MYCN induces cell-specific tumorigenic growth in RB1-proficient human retinal organoid and chicken retina models of retinoblastoma

Blixt, Maria; Hellsand, Minas; Konjusha, Dardan; Zhang, Hanzhao et al.

Part of Oncogenesis, 2022
- DOI for MYCN induces cell-specific tumorigenic growth in RB1-proficient human retinal organoid and chicken retina models of retinoblastoma
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Aniridia with PAX6 mutations and narcolepsy

Ghaderi Berntsson, Shala; Kristoffersson, Anna; Daniilidou, Makrina; Dahl, Niklas et al.

Part of Journal of Sleep Research, 2020
- DOI for Aniridia with PAX6 mutations and narcolepsy
Brain Transcriptomics of Wild and Domestic Rabbits Suggests That Changes in Dopamine Signaling and Ciliary Function Contributed to Evolution of Tameness

Sato, Daiki X.; Rafati, Nima; Ring, Henrik; Younis, Shady et al.

Part of Genome Biology and Evolution, p. 1918-1928, 2020
- DOI for Brain Transcriptomics of Wild and Domestic Rabbits Suggests That Changes in Dopamine Signaling and Ciliary Function Contributed to Evolution of Tameness
Deletion in the Bardet-Biedl Syndrome Gene TTC8 Results in a Syndromic Retinal Degeneration in Dogs

Mäkeläinen, Suvi; Hellsand, Minas; van Der Heiden, Anna Darlene; Andersson, Elina et al.

Part of Genes, 2020
- DOI for Deletion in the Bardet-Biedl Syndrome Gene TTC8 Results in a Syndromic Retinal Degeneration in Dogs
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High-Resolution Imaging of Tumor Spheroids and Organoids Enabled by Expansion Microscopy

Edwards, Steven J.; Carannante, Valentina; Kuhnigk, Kyra; Ring, Henrik et al.

Part of Frontiers in Molecular Biosciences, 2020
- DOI for High-Resolution Imaging of Tumor Spheroids and Organoids Enabled by Expansion Microscopy
- Download full text (pdf) of High-Resolution Imaging of Tumor Spheroids and Organoids Enabled by Expansion Microscopy
Alpha 2-Adrenergic Receptor Agonist Brimonidine Stimulates ERK1/2 and AKT Signaling via Transactivation of EGF Receptors in the Human MIO-M1 Müller Cell Line

Harun-Or-Rashid, Mohammad; Hallböök, Finn

Part of Current Eye Research, p. 34-45, 2019
- DOI for Alpha 2-Adrenergic Receptor Agonist Brimonidine Stimulates ERK1/2 and AKT Signaling via Transactivation of EGF Receptors in the Human MIO-M1 Müller Cell Line
An ABCA4 loss-of-function mutation causes a canine form of Stargardt disease

Mäkeläinen, Suvi; Gòdia, Marta; Hellsand, Minas; Viluma, Agnese et al.

Part of PLOS Genetics, 2019
- DOI for An ABCA4 loss-of-function mutation causes a canine form of Stargardt disease
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Changes in brain architecture are consistent with altered fear processing in domestic rabbits

Brusini, Irene; Carneiro, Miguel; Wang, Chunliang; Rubin, Carl-Johan et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 7380-7385, 2018
- DOI for Changes in brain architecture are consistent with altered fear processing in domestic rabbits
Zinc finger gene nolz1 regulates the formation of retinal progenitor cells and suppresses the Lim3/Lhx3 phenotype of retinal bipolar cells in chicken retina

Blixt, Maria K. E.; Konjusha, Dardan; Ring, Henrik; Hallböök, Finn

Part of Developmental Dynamics, p. 630-641, 2018
- DOI for Zinc finger gene nolz1 regulates the formation of retinal progenitor cells and suppresses the Lim3/Lhx3 phenotype of retinal bipolar cells in chicken retina
Heterogeneity in retinoblastoma: a tale of molecules and models

Stenfelt, Sonya; Blixt, Maria K. E.; All-Ericsson, Charlotta; Hallböök, Finn et al.

Part of CLINICAL AND TRANSLATIONAL MEDICINE, 2017
- DOI for Heterogeneity in retinoblastoma: a tale of molecules and models
- Download full text (pdf) of Heterogeneity in retinoblastoma: a tale of molecules and models
The evolution of Sex-linked barring alleles in chickens involves both regulatory and coding changes in CDKN2A

Thalmann, Doreen Schwochow; Ring, Henrik; Sundström, Elisabeth; Cao, Xiaofang et al.

Part of PLOS Genetics, 2017
- DOI for The evolution of Sex-linked barring alleles in chickens involves both regulatory and coding changes in CDKN2A
- Download full text (pdf) of The evolution of Sex-linked barring alleles in chickens involves both regulatory and coding changes in CDKN2A
A regulatory sequence from the retinoid X receptor gamma gene directs expression to horizontal cells and photoreceptors in the embryonic chicken retina

Blixt, Maria; Hallböök, Finn

Part of Molecular Vision, p. 1405-1420, 2016
Endothelin B Receptors on Primary Chicken Müller Cells and the Human MIO-M1 Müller Cell Line Activate ERK Signaling via Transactivation of Epidermal Growth Factor Receptors

Harun-Or-Rashid, Mohammad; Konjusha, Dardan; Galindo-Romero, Caridad; Hallböök, Finn

Part of PLOS ONE, 2016
- DOI for Endothelin B Receptors on Primary Chicken Müller Cells and the Human MIO-M1 Müller Cell Line Activate ERK Signaling via Transactivation of Epidermal Growth Factor Receptors
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Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease

Boije, Henrik; Fard, Shahrzad Shirazi; Edqvist, Per-Henrik; Hallböök, Finn

Part of Frontiers in Neuroanatomy, 2016
- DOI for Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease
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Lineage tracing of horizontal and photoreceptor cells in the embryonic chicken retina

Blixt, Maria; Hallböök, Finn

Part of Investigative Ophthalmology and Visual Science, 2016
Neuroprotection by α2-Adrenergic Receptor Stimulation after Excitotoxic Retinal Injury: A Study of the Total Population of Retinal Ganglion Cells and Their Distribution in the Chicken Retina

Galindo-Romero, Caridad; Harun-Or-Rashid, Mohammad; Jiménez-López, Manuel; Agudo-Barriuso, Manuel et al.

Part of PLOS ONE, 2016
- DOI for Neuroprotection by α2-Adrenergic Receptor Stimulation after Excitotoxic Retinal Injury: A Study of the Total Population of Retinal Ganglion Cells and Their Distribution in the Chicken Retina
- Download full text (pdf) of Neuroprotection by α2-Adrenergic Receptor Stimulation after Excitotoxic Retinal Injury: A Study of the Total Population of Retinal Ganglion Cells and Their Distribution in the Chicken Retina
A Genomic Duplication is Associated with Ectopic Eomesodermin Expression in the Embryonic Chicken Comb and Two Duplex-comb Phenotypes

Dorshorst, Ben; Harun-Or-Rashid, Mohammad; Bagherpoor, Alireza Jian; Rubin, Carl-Johan et al.

Part of PLOS Genetics, 2015
- DOI for A Genomic Duplication is Associated with Ectopic Eomesodermin Expression in the Embryonic Chicken Comb and Two Duplex-comb Phenotypes
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Adding another piece to the retinoblastoma puzzle

Blixt, Martin K. E.; Shirazi Fard, Shahrzad; All-Ericsson, C; Hallböök, Finn

Part of Cell Death and Disease, 2015
- DOI for Adding another piece to the retinoblastoma puzzle
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Alpha2-Adrenergic-Agonist Brimonidine Stimulates Negative Feedback and Attenuates Injury-Induced Phospho-ERK and Dedifferentiation of Chicken Müller Cells

Harun-Or-Rashid, Mohammad; Diaz-DelCastillo, Marta; Galindo-Romero, Caridad; Hallböök, Finn

Part of Investigative Ophthalmology and Visual Science, p. 5933-5945, 2015
- DOI for Alpha2-Adrenergic-Agonist Brimonidine Stimulates Negative Feedback and Attenuates Injury-Induced Phospho-ERK and Dedifferentiation of Chicken Müller Cells
- Download full text (pdf) of Alpha2-Adrenergic-Agonist Brimonidine Stimulates Negative Feedback and Attenuates Injury-Induced Phospho-ERK and Dedifferentiation of Chicken Müller Cells
The p53 co-activator Zac1 neither induces cell cycle arrest nor apoptosis in chicken Lim1 horizontal progenitor cells

Fard, Shahrzad Shirazi; Blixt, Maria; Hallböök, Finn

Part of Cell Death Discovery, 2015
- DOI for The p53 co-activator Zac1 neither induces cell cycle arrest nor apoptosis in chicken Lim1 horizontal progenitor cells
Whole Retinal Explants from Chicken Embryos for Electroporation and Chemical Reagent Treatments

Fard, Shahrzad Shirazi; Blixt, Maria; Hallböök, Finn

Part of Journal of Visualized Experiments, 2015
- DOI for Whole Retinal Explants from Chicken Embryos for Electroporation and Chemical Reagent Treatments
Specific spatial distribution of caspase-3 in normal lenses

Talebizadeh, Nooshin; Yu, Zhaohua; Martin, Kronschläger; Finn, Hallböök et al.

Part of Acta Ophthalmologica, p. 289-292, 2014
- DOI for Specific spatial distribution of caspase-3 in normal lenses
The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway

Fard, Shahrzad Shirazi; All-Ericsson, Charlotta; Hallböök, Finn

Part of Cell Cycle, p. 408-417, 2014
- DOI for The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway
The terminal basal mitosis of chicken retinal Lim1 horizontal cells is not sensitive to cisplatin-induced cell cycle arrest

Shirazi Fard, Shahrzad; Thyselius, Malin; All-Ericsson, Charlotta; Hallböök, Finn

Part of Cell Cycle, p. 3698-3706, 2014
- DOI for The terminal basal mitosis of chicken retinal Lim1 horizontal cells is not sensitive to cisplatin-induced cell cycle arrest
- Download full text (pdf) of The terminal basal mitosis of chicken retinal Lim1 horizontal cells is not sensitive to cisplatin-induced cell cycle arrest
Transactivation of EGF Receptors in Chicken Muller Cells by α2A-Adrenergic Receptors Stimulated by Brimonidine

Harun-Or-Rashid, Mohammad; Lindqvist, Niclas; Hallböök, Finn

Part of Investigative Ophthalmology and Visual Science, p. 3385-3394, 2014
- DOI for Transactivation of EGF Receptors in Chicken Muller Cells by α2A-Adrenergic Receptors Stimulated by Brimonidine
Alternative Splicing of the Chromodomain Protein Morf4l1 Pre-mRNA Has Implications on Cell Differentiation in the Developing Chicken Retina

Boije, Henrik; Ring, Henrik; Fard, Shahrzad Shirazi; Grundberg, Ida et al.

Part of Journal of Molecular Neuroscience, p. 615-628, 2013
- DOI for Alternative Splicing of the Chromodomain Protein Morf4l1 Pre-mRNA Has Implications on Cell Differentiation in the Developing Chicken Retina
Evolution of TUNEL-labeling in the Rat Lens After In Vivo Exposure to Just Above Threshold Dose UVB

Kronschläger, Martin; Yu, Zhaohua; Talebizadeh, Nooshin; Meyer, Linda M. et al.

Part of Current Eye Research, p. 880-885, 2013
- DOI for Evolution of TUNEL-labeling in the Rat Lens After In Vivo Exposure to Just Above Threshold Dose UVB
Forkheadbox N4 (FoxN4) triggers context-dependent differentiation in the developing chick retina and neural tube

Boije, Henrik; Shirazi Fard, S.; Ring, Henrik; Hallböök, Finn

Part of Differentiation, p. 11-19, 2013
- DOI for Forkheadbox N4 (FoxN4) triggers context-dependent differentiation in the developing chick retina and neural tube
Heterogenic Final Cell Cycle by Chicken Retinal Lim1 Horizontal Progenitor Cells Leads to Heteroploid Cells with a Remaining Replicated Genome

Fard, Shahrzad Shirazi; Jarrin, Miguel; Boije, Henrik; Fillon, Valerie et al.

Part of PLOS ONE, 2013
- DOI for Heterogenic Final Cell Cycle by Chicken Retinal Lim1 Horizontal Progenitor Cells Leads to Heteroploid Cells with a Remaining Replicated Genome
- Download full text (pdf) of Heterogenic Final Cell Cycle by Chicken Retinal Lim1 Horizontal Progenitor Cells Leads to Heteroploid Cells with a Remaining Replicated Genome
The expression of carnitine palmitoyl-CoA transferase-1B is influenced by a cis-acting eQTL in two chicken lines selected for high and low body weight

Ka, Sojeong; Markljung, Ellen; Ring, Henrik; Albert, Frank W et al.

Part of Physiological Genomics, p. 367-376, 2013
- DOI for The expression of carnitine palmitoyl-CoA transferase-1B is influenced by a cis-acting eQTL in two chicken lines selected for high and low body weight
GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium:

Ring, Henrik; Mendu, Suresh Kumar; Shirazi-Fard, Shahrzad; Birnir, Bryndis et al.

Part of PLOS ONE, 2012
- DOI for GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium:
- Download full text (pdf) of GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium:
Platelet-derived growth factor over-expression in retinal progenitors results in abnormal retinal vessel formation

Edqvist, Per-Henrik D; Niklasson, Mia; Vidal-Sanz, Manuel; Hallböök, Finn et al.

Part of PLOS ONE, 2012
- DOI for Platelet-derived growth factor over-expression in retinal progenitors results in abnormal retinal vessel formation
- Download full text (pdf) of Platelet-derived growth factor over-expression in retinal progenitors results in abnormal retinal vessel formation
Sonic Hedgehog-Signalling Patterns the Developing Chicken Comb as Revealed by Exploration of the Pea-comb Mutation

Boije, Henrik; Harun-Or-Rashid, Mohammad; Lee, Yu-Jen; Imsland, Freyja et al.

Part of PLOS ONE, 2012
- DOI for Sonic Hedgehog-Signalling Patterns the Developing Chicken Comb as Revealed by Exploration of the Pea-comb Mutation
- Download full text (pdf) of Sonic Hedgehog-Signalling Patterns the Developing Chicken Comb as Revealed by Exploration of the Pea-comb Mutation
The Rose-comb Mutation in Chickens Constitutes a Structural Rearrangement Causing Both Altered Comb Morphology and Defective Sperm Motility

Imsland, Freyja; Feng, Chungang; Boije, Henrik; Bed'hom, Bertrand et al.

Part of PLOS Genetics, 2012
- DOI for The Rose-comb Mutation in Chickens Constitutes a Structural Rearrangement Causing Both Altered Comb Morphology and Defective Sperm Motility
- Download full text (pdf) of The Rose-comb Mutation in Chickens Constitutes a Structural Rearrangement Causing Both Altered Comb Morphology and Defective Sperm Motility
A Complex Genomic Rearrangement Involving the Endothelin 3 Locus Causes Dermal Hyperpigmentation in the Chicken

Dorshorst, Ben; Molin, Anna-Maja; Rubin, Carl-Johan; Johansson, Anna M. et al.

Part of PLoS Genetics, 2011
- DOI for A Complex Genomic Rearrangement Involving the Endothelin 3 Locus Causes Dermal Hyperpigmentation in the Chicken
Differentially expressed genes in hypothalamus in relation to genomic regions under selection in two chicken lines resulting from divergent selection for high or low body weight

Ka, Sojeong; Albert, Frank W.; Denbow, D. Michael; Pääbo, Svante et al.

Part of Neurogenetics, p. 211-221, 2011
- DOI for Differentially expressed genes in hypothalamus in relation to genomic regions under selection in two chicken lines resulting from divergent selection for high or low body weight
Inactivation of Pmel Alters Melanosome Shape But Has Only a Subtle Effect on Visible Pigmentation

Hellström, Anders R.; Watt, Brenda; Fard, Shahrzad Shirazi; Tenza, Daniele et al.

Part of PLoS Genetics, 2011
- DOI for Inactivation of Pmel Alters Melanosome Shape But Has Only a Subtle Effect on Visible Pigmentation
Ptf1a/Rbpj complex inhibits ganglion cell fate and drives the specification of all horizontal cell subtypes in the chick retina

Lelièvre, E.C.; Lek, M.; Boije, H.; Houille-Vernes, L. et al.

Part of Developmental Biology, p. 296-308, 2011
- DOI for Ptf1a/Rbpj complex inhibits ganglion cell fate and drives the specification of all horizontal cell subtypes in the chick retina
Increased A-to-I RNA editing of the transcript for GABA_A receptor subunit α3 during chick retinal development

Ring, Henrik; Boije, Henrik; Daniel, Chammiran; Ohlson, Johan et al.

Part of Visual Neuroscience, p. 149-157, 2010
- DOI for Increased A-to-I RNA editing of the transcript for GABA_A receptor subunit α3 during chick retinal development
Multiple receptor tyrosine kinases are expressed in adult rat retinal ganglion cells as revealed by single-cell degenerate primer polymerase chain reaction

Lindqvist, Niclas; Lönngren, Ulrika; Agudo, Marta; Näpänkangas, Ulla et al.

Part of Upsala Journal of Medical Sciences, p. 65-80, 2010
- DOI for Multiple receptor tyrosine kinases are expressed in adult rat retinal ganglion cells as revealed by single-cell degenerate primer polymerase chain reaction
Pax2 Is Expressed in a Subpopulation of Muller Cells in the Central Chick Retina

Boije, Henrik; Ring, Henrik; Lopez-Gallardo, Meritxell; Prada, Carmen et al.

Part of Developmental Dynamics, p. 1858-1866, 2010
- DOI for Pax2 Is Expressed in a Subpopulation of Muller Cells in the Central Chick Retina
Whole genome resequencing reveals loci under selection during chicken domestication

Rubin, Carl-Johan; Zody, Michael C.; Eriksson, Jonas; Meadows, Jennifer et al.

Part of Nature, p. 587-591, 2010
- DOI for Whole genome resequencing reveals loci under selection during chicken domestication
Copy number variation in intron 1 of SOX5 causes the Pea-comb phenotype in chickens

Wright, Dominic; Boije, Henrik; Meadows, Jennifer; Bed'hom, Bertrand et al.

Part of PLoS Genetics, 2009
- DOI for Copy number variation in intron 1 of SOX5 causes the Pea-comb phenotype in chickens
Extremely different behaviours in high and low body weight lines of chicken are associated with differential expression of genes involved in neuronal plasticity

Ka, Sojeong; Lindberg, J.; Strömstedt, L.; Fitzsimmons, C. et al.

Part of Journal of neuroendocrinology, p. 208-216, 2009
- DOI for Extremely different behaviours in high and low body weight lines of chicken are associated with differential expression of genes involved in neuronal plasticity
Horizontal cell progenitors arrest in G2-phase and undergo terminal mitosis on the vitreal side of the chick retina

Boije, Henrik; Edqvist, Per-Henrik D.; Hallböök, Finn

Part of Developmental Biology, p. 105-113, 2009
- DOI for Horizontal cell progenitors arrest in G2-phase and undergo terminal mitosis on the vitreal side of the chick retina
Immediate Upregulation of Proteins Belonging to Different Branches of the Apoptotic Cascade in the Retina after Optic Nerve Transection and Optic Nerve Crush

Agudo, Marta; Perez-Marin, Maria Cruz; Sobrado-Calvo, Paloma; Lönngren, Ulrika et al.

Part of Investigative Ophthalmology and Visual Science, p. 424-431, 2009
- DOI for Immediate Upregulation of Proteins Belonging to Different Branches of the Apoptotic Cascade in the Retina after Optic Nerve Transection and Optic Nerve Crush
Proviral integrations and expression of endogenous Avian leucosis virus during long term selection for high and low body weight in two chicken lines

Ka, Sojeong; Kerje, Susanne; Bomold, Lina; Liljegren, Ulrika et al.

Part of Retrovirology, p. 68, 2009
- DOI for Proviral integrations and expression of endogenous Avian leucosis virus during long term selection for high and low body weight in two chicken lines
The Dominant white mutation in the PMEL17 gene does not cause visual impairment in chickens

Karlsson, Anna-Carin; Kerje, Susanne; Hallböök, Finn; Jensen, Per

Part of Veterinary Ophthalmology, p. 292-298, 2009
- DOI for The Dominant white mutation in the PMEL17 gene does not cause visual impairment in chickens
Axon-bearing and axon-less horizontal cell subtypes are generated consecutively during chick retinal development from progenitors that are sensitive to follistatin

Edqvist, Per-Henrik D; Lek, Madelen; Boije, Henrik; Lindbäck, Sarah M et al.

Part of BMC Developmental Biology, p. 46, 2008
- DOI for Axon-bearing and axon-less horizontal cell subtypes are generated consecutively during chick retinal development from progenitors that are sensitive to follistatin
Temporal and spatial expression of transcription factors FoxN4, Ptf1a, Prox1, Isl1 and Lim1 mRNA in the developing chick retina

Boije, Henrik; Edqvist, Per-Henrik D; Hallböök, Finn

Part of Gene Expression Patterns, p. 117-123, 2008
- DOI for Temporal and spatial expression of transcription factors FoxN4, Ptf1a, Prox1, Isl1 and Lim1 mRNA in the developing chick retina
The amphioxus genome illuminates vertebrate origins and cephalochordate biology

Holland, Linda Z; Albalat, Ricard; Azumi, Kaoru; Benito-Gutiérrez, Elia et al.

Part of Genome Research, p. 1100-1111, 2008
- DOI for The amphioxus genome illuminates vertebrate origins and cephalochordate biology
Time course profiling of the retinal transcriptome after optic nerve transection and optic nerve crush

Agudo, Marta; Pérez-Marín, Maria Cruz; Lönngren, Ulrika; Sobrado, Paloma et al.

Part of Molecular Vision, p. 1050-1063, 2008
Differential, age-dependent MEK-ERK and PI3K-Akt activation by insulin acting as a survival factor during embryonic retinal development

Chavarría, Teresa; Valenciano, Ana I.; Mayordomo, Raquel; Egea, Joaquim et al.

Part of Developmental Neurobiology, p. 1777-1788, 2007
- DOI for Differential, age-dependent MEK-ERK and PI3K-Akt activation by insulin acting as a survival factor during embryonic retinal development
Neurotransmitter phenotype-specific expression changes in developing sympathetic neurons

Apostolova, Galina; Dorn, Roland; Ka, Sojeong; Hallböök, Finn et al.

Part of Molecular and Cellular Neuroscience, p. 397-408, 2007
- DOI for Neurotransmitter phenotype-specific expression changes in developing sympathetic neurons
A genomic view of the sea urchin nervous system

Burke, R D; Angerer, L M; Elphick, M R; Humphrey, G W et al.

Part of Developmental Biology, p. 434-460, 2006
- DOI for A genomic view of the sea urchin nervous system
Conserved Synteny Between the Ciona Genome and Human Paralogons Identifies Large Duplication Events in the Molecular Evolution of the Insulin-Relaxin Gene Family

Olinski, Robert; Lundin, Lars-Gustav; Hallböök, Finn

Part of Molecular biology and evolution, p. 10-22, 2006
- DOI for Conserved Synteny Between the Ciona Genome and Human Paralogons Identifies Large Duplication Events in the Molecular Evolution of the Insulin-Relaxin Gene Family
Early identification of retinal subtypes in the developing, pre-laminated chick retina using the transcription factors Prox1, Lim1, Ap2α, Pax6, Isl1, Isl2, Lim3 and Chx10

Edqvist, Per-Henrik; Myers, Sarah; Hallböök, Finn

Part of European journal of histochemistry, p. 147-154, 2006
- DOI for Early identification of retinal subtypes in the developing, pre-laminated chick retina using the transcription factors Prox1, Lim1, Ap2α, Pax6, Isl1, Isl2, Lim3 and Chx10
Formation and evolution of the chordate neurotrophin and Trk receptor genes.

Hallbook, Finn; Wilson, Karen; Thorndyke, Mike; Olinski, Robert

Part of Brain Behav Evol, p. 133-44, 2006
Formation and evolution of the chordate neurotrophin and Trk receptor genes

Hallböök, Finn; Wilson, Karen; Thorndyke, Mike; Olinski, Robert Piotr

Part of Brain, behavior, and evolution, p. 133-144, 2006
- DOI for Formation and evolution of the chordate neurotrophin and Trk receptor genes
The genome of the sea urchin Strongylocentrotus purpuratus

Sodergren, Erica; Weinstock, George M.; Davidson, Eric H.; Cameron, R. Andrew et al.

Part of Science, p. 941-952, 2006
- DOI for The genome of the sea urchin Strongylocentrotus purpuratus
Three insulin-relaxin-like genes in Ciona intestinalis

Olinski, Robert; Dahlberg, Carl; Thorndyke, Mike; Hallböök, Finn

Part of Peptides, p. 2535-2546, 2006
- DOI for Three insulin-relaxin-like genes in Ciona intestinalis
Expression analysis of growth and energy regulation-associated genes in two divergent chicken strains.

Ka, Sojeong; Fitzsimmons, Carolyn; Jacobsson, Lina; Savolainen, Peter et al.

Part of Ann N Y Acad Sci, p. 357-9, 2005
Genome duplication-driven evolution of gene families: insights from the formation of the insulin family

Olinski, Robert; Lundin, Lars-Gustav; Hallböök, Finn

Part of Ann N Y Acad Sci, p. 426-428, 2005
GDNF, Ret, GFRalpha1 and 2 in the adult rat retino-tectal system after optic nerve transection

Lindqvist, Niclas; Peinado-Ramon, Paloma; Vidal-Sanz, Manuel; Hallbook, Finn

Part of Experimental Neurology, p. 487-489, 2004
Newborn horizontal cells migrate bi-directionally across the neuroepithelium during retinal development

Edqvist, Per-Henrik; Hallbook, Finn

Part of Development, p. 1343-1251, 2004
An Improved Cell Culture Model Based on 2/4/A1 Cell Monolayers for Studies of Intestinal Drug Transport

Tavelin, Staffan; Taipalensuu, Jan; Hallböök, Finn; Vellonen, Kati-Sisko et al.

Part of Pharmaceutical research, p. 373-381, 2003
- DOI for An Improved Cell Culture Model Based on 2/4/A1 Cell Monolayers for Studies of Intestinal Drug Transport
An improved cell culture model based on 2/4/A1 cell monolayers for studies of intestinal drug transport: characterization of transport routes

Tavelin, Staffan; Taipalensuu, Jan; Hallböök, Finn; Vellonen, Kati-Sisko et al.

Part of Pharmaceutical research, p. 373-381, 2003
- DOI for An improved cell culture model based on 2/4/A1 cell monolayers for studies of intestinal drug transport: characterization of transport routes
Generation of retinal ganglion cells is modulated by caspase-dependent programmed cell death

Mayordomo, Raquel; Valenciano, Ana; Rosa de la, Enrique; Hallböök, Finn

Part of European Journal of Neuroscience, p. 1744-1750, 2003
- DOI for Generation of retinal ganglion cells is modulated by caspase-dependent programmed cell death
Numerous groups of chromosomal regional paralogies strongly indicate two genome doublings at the root of the vertebrates

Lundin, Lars-Gustav; Larhammar, Dan; Hallböök, Finn

Part of Journal of Structural and Functional Genomics, p. 53-63, 2003
- DOI for Numerous groups of chromosomal regional paralogies strongly indicate two genome doublings at the root of the vertebrates
Proopiomelanocortin and melanocortin receptors in the adult rat retino-tectal system and their regulation after optic nerve transection

Lindqvist, Niclas; Näpänkangas, Ulla; Lindblom, Jonas; Hallböök, Finn

Part of European Journal of Pharmacology, p. 85-94, 2003
- DOI for Proopiomelanocortin and melanocortin receptors in the adult rat retino-tectal system and their regulation after optic nerve transection
Rat retinal ganglion cells upregulate the pro-apoptotic BH3-only protein Bim after optic nerve transection

Näpänkangas, Ulla; Lindqvist, Niclas; Lindholm, Dan; Hallböök, Finn

Part of Brain Research. Molecular Brain Research, p. 30-37, 2003
- DOI for Rat retinal ganglion cells upregulate the pro-apoptotic BH3-only protein Bim after optic nerve transection
Biotin decreases retinal apoptosis and induces eye malformations in the early chick embryo

Valenciano, Ana; Mayordomo, Raquel; de la Rosa, Enrique; Hallböök, Finn

Part of NeuroReport, p. 297-299, 2002
Overlapping and specific patterns of GDNF, c-ret and GFR mRNA expression in the developing chicken retina

Karlsson, Miriam; Lindqvist, Niclas; Mayordomo, Raquel; Hallböök, Finn

Part of Mechanisms of Development, p. 161-165, 2002
- DOI for Overlapping and specific patterns of GDNF, c-ret and GFR mRNA expression in the developing chicken retina
The human hox-bearing chromosome regions did arise by block or chromosome (or even genome) duplications

Larhammar, Dan; Lundin, Lars-Gustav; Hallböök, Finn

Part of Genome Research, p. 1910-1920, 2002
- DOI for The human hox-bearing chromosome regions did arise by block or chromosome (or even genome) duplications
Nerve growth factor is expressed by postmitotic avian retinal horizontal cells and supports their survival during development in an autocrine mode of action

Karlsson, Miriam; Mayordomo, Raquel; Reichardt, Louis; Catsicas, Stefan et al.

Part of Development, p. 471-479, 2001
Analysis of subcellular location of bestrophin in transfected RPE cell lines

Bakall, Benjamin; Mayordomo, Raquel; Hallböök, Finn; Wadelius, Claes

Part of Gene Function and Disease, p. 128-133, 2000
- DOI for Analysis of subcellular location of bestrophin in transfected RPE cell lines
Gene functional analysis in nervous system

Hallböök, Finn; Catsicas, M; Staple, J K; Grenningloh, G et al.

Part of Methods in Enzymology, p. 148-167, 2000
- DOI for Gene functional analysis in nervous system
Gene functional analysis in the nervous system

Hallböök, Finn; Catsicas, M; Staple, JK; Grenningloh, G et al.

Part of Methods in Enzymology, p. 148-167, 2000
- DOI for Gene functional analysis in the nervous system
Evolution of the vertebrate neurotrophin and Trk receptor gene families

Hallböök, Finn

Part of Current Opinion in Neurobiology, p. 616-621, 1999
- DOI for Evolution of the vertebrate neurotrophin and Trk receptor gene families
Evolution of the vertebrate neurotrophin and Trk receptor gene families

Hallböök, Finn

Part of Current Opinion in Neurobiology, p. 616-621, 1999
- DOI for Evolution of the vertebrate neurotrophin and Trk receptor gene families
Kainic acid, tetrodotoxin and light modulate expression of brain-derived neurotrophic factor in developing avian retinal ganglion cells and their tectal target

Karlsson, Miriam; Hallböök, Finn

Part of Neuroscience, p. 137-150, 1998
- DOI for Kainic acid, tetrodotoxin and light modulate expression of brain-derived neurotrophic factor in developing avian retinal ganglion cells and their tectal target
Lampetra fluviatilis neurotrophin homolog, descendant of a neurotrophin ancestor, discloses the early molecular evolution of neurotrophins in the vertebrate subphylum

Hallböök, Finn; Lundin, Lars-Gustav; Kullander, Klas

Part of Journal of Neuroscience, p. 8700-8711, 1998
MAP kinase phosphatase-1 mRNA is expressed in embryonic sympathetic neurons and is upregulated after NGF stimulation

Peinado-Ramón, Paloma; Wallén, Åsa; Hallböök, Finn

Part of Brain Research. Molecular Brain Research, p. 256-267, 1998
- DOI for MAP kinase phosphatase-1 mRNA is expressed in embryonic sympathetic neurons and is upregulated after NGF stimulation
Nerve growth factor receptor TrkA is expressed by horizontal and amacrine cells during chicken retinal development

Karlsson, Miriam; Clary, D; Lefcort, F; Reichardt, L et al.

Part of J. Comp. Neurol., p. 408-416, 1998
- DOI for Nerve growth factor receptor TrkA is expressed by horizontal and amacrine cells during chicken retinal development
Nerve growth factor receptor TrkA is expressed by horizontal and amacrine cells during chicken retinal development

Karlsson, Miriam; Clary, D O; Lefcort, F B; Reichardt, L F et al.

Part of Journal of Comparative Neurology, p. 408-416, 1998
- DOI for Nerve growth factor receptor TrkA is expressed by horizontal and amacrine cells during chicken retinal development
Characterization and evaluation of antisense oligonucleotides: inhibition of NGF synthesis in transfected COS cells

Hallböök, Finn; Sahlén, Anders; Catsicas, S

Part of Antisense and Nucleic Acid Drug Development, p. 89-100, 1997
- DOI for Characterization and evaluation of antisense oligonucleotides: inhibition of NGF synthesis in transfected COS cells
Distribution of BDNF and trkB mRNA in the otic region of 3.5 and 4.5 day chick embryos as revealed with a combination of in situ hybridization and tract tracing

Hallböök, Finn; Fritzsch, B

Part of International Journal of Developmental Biology, p. 725-732, 1997
Expression of neurotrophins and Trk receptors in the developing, adult, and regenerating avian cochlea

Pirvola, U; Hallböök, Finn; Xing-Qun, L; Virkkala, J et al.

Part of Journal of Neurobiology, p. 1019-1033, 1997
- DOI for Expression of neurotrophins and Trk receptors in the developing, adult, and regenerating avian cochlea
Human mast cells express functional TrkA and are a source of nerve growth factor

Nilsson, Gunnar; Forsberg-Nilsson, Karin; Xiang, Z; Hallböök, Finn et al.

Part of European Journal of Immunology, p. 2295-2301, 1997
- DOI for Human mast cells express functional TrkA and are a source of nerve growth factor
Molecular phylogeny and evolution of the neurotrophins from monotremes and marsupials

Kullander, Klas; Carlsson, Barbro; Hallböök, Finn

Part of Journal of Molecular Evolution, p. 311-321, 1997
- DOI for Molecular phylogeny and evolution of the neurotrophins from monotremes and marsupials
A simple and reliable technique to combine oligonucleotide probe in situ hybridization with neuronal tract tracing in vertebrate embryos.

Fritzsch, B; Hallböök, F

Part of Biotechnic & Histochemistry, p. 289-94, 1996
Expression of neurotrophins and trk receptors in the avian retina

Hallböök, Finn; Bäckström, Anders; Kullander, Klas; Ebendal, Ted et al.

Part of Journal of Comparative Neurology, p. 664-676, 1996
- DOI for Expression of neurotrophins and trk receptors in the avian retina
Developmentally-regulated expression of mRNA for neurotrohin high-affinity (trk) receptors within chich trigeminal sensory neurons

Williams, R; Bäckström, Anders; Kullander, Klas; Hallböök, Finn et al.

Part of European Journal of Neuroscience, p. 116-128, 1995
Neurotrophins and their receptors in chicken neuronal development

Hallböök, Finn; Bäckström, Anders; Kullander, Klas; Kylberg, Annika et al.

Part of International Journal of Developmental Biology, p. 855-868, 1995
Differential actions of neurotrophins in the locus coeruleus and basal forebrain.

Friedman, W J; Ibáñez, C F; Hallböök, F; Persson, H et al.

Part of Experimental Neurology, p. 72-8, 1993
- DOI for Differential actions of neurotrophins in the locus coeruleus and basal forebrain.
Expression of neurotrophin-4 mRNA during oogenesis in Xenopus laevis.

Ibáñez, C F; Hallböök, F; Godeau, F; Persson, H

Part of International Journal of Developmental Biology, p. 239-45, 1992
Distinct functions for thyroid hormone receptors alpha and beta in brain development indicated by differential expression of receptor genes.

Forrest, D; Hallböök, F; Persson, H; Vennström, B

Part of EMBO Journal, p. 269-75, 1991
Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary.

Hallböök, F; Ibáñez, C F; Persson, H

Part of Neuron, p. 845-58, 1991
Human nerve growth factor: biological and immunological activities, and clinical possibilities in neurodegenerative disease.

Ebendal, T; Söderström, S; Hallböök, F; Ernfors, P et al.

Part of Advances in Experimental Medicine and Biology, p. 207-25, 1991

Research areas

Neuro-oncology and Neurodegeneration