Finn Hallböök – Stamceller, retinal utveckling och regeneration

Vår forskning handlar om hur nervceller i ögats näthinna (retina) bildas från stamceller och förstadieceller. Målet är att förstå vad som gått fel i nervcellsbildningen när det utvecklas cancer i retina i ögat: retinoblastom. Vår forskning syftar också till att kunna styra nervcellsbildningen mot att antingen bilda nya nervceller eller bli stödjande gliaceller vid skador eller sjukdomar

Vi studerar hur celler övergår från förstadieceller till nervceller och hur de sista ”terminala” celldelningarna hos förstadiecellerna regleras innan de blir mogna nervceller som normalt slutar dela sig och bygger upp en funktionell retina. Vi studerar även när dessa terminala celldelningar blir störda t.ex. efter onkogena mutationer och som då kan bidra till att cancer utvecklas i ögat. Våra studier gäller främst uppkomsten av retinoblastom.

Odlad retina med liknande funktioner som i ögat

Vi använder ett stamcellsbaserat system för att studera nervcellsbildning i mänsklig retina. Med utgångspunkt från pluripotenta stamceller kan vi tillverka human retin och följa nervcellsbildningen i cellkultur, sk ex vivo. Dessa kulturer bildar små ”miniögon”, s.k. retinala organoider, och innehåller alla celltyper som finns i den normala retinan. Bildmningen följer den normala utvecklingen hos foster och bran. Organoiderna har funktionella nervceller, svarar på ljus och bygger upp nätverk av nervcellsuppkopplingar.

De retinala organoiderna är en kraftfull modell för att studera nervcellsbildning i mänsklig retina ex vivo under perioder som sker under fosterutvecklingen i livmodern. Vi har nyligen visat att organoiderna kan användas för att studera uppkomsten av retinoblastom. Vi använder även väl studerade djurmodeller som komplement till organoiderna för in vivo-studier och djurmodellerna används för att utveckla våra forskningshypoteser.

Forskningsprojekt

Studier av retinal nervcellsbildning.
Studier av uppkomsten av retinoblastom – fokus på egenskaper som gör specifika förstadieceller benägna att utveckla förstadier till retinoblastom, s.k. ”cell-of-origin for retinoblastoma”.
Etablering av en stamcells-deriverad human retinamodell och studier av mänsklig nervcellsbildning in vitro.
Studier av endogena retinala stamceller och deras reglering med avseende på regeneration och protektion vid skada och sjukdom.

Gruppmedlemmar

Forskningsledare: Finn Hallböök

Gruppmedlemmar: Suvi Mäkeläinen, Henrik Ring, Tatsiana Tararuk

Publikationer

Inhibition of high level E2F in a RB1 proficient MYCN overexpressing chicken retinoblastoma model normalizes neoplastic behaviour

Zhang, Hanzhao; Konjusha, Dardan; Rafati, Nima; Tararuk, Tatsiana et al.

Ingår i Cellular Oncology, s. 209-227, 2024
- DOI för Inhibition of high level E2F in a RB1 proficient MYCN overexpressing chicken retinoblastoma model normalizes neoplastic behaviour
- Ladda ner fulltext (pdf) av Inhibition of high level E2F in a RB1 proficient MYCN overexpressing chicken retinoblastoma model normalizes neoplastic behaviour
MYCN induces cell-specific tumorigenic growth in RB1-proficient human retinal organoid and chicken retina models of retinoblastoma

Blixt, Maria; Hellsand, Minas; Konjusha, Dardan; Zhang, Hanzhao et al.

Ingår i Oncogenesis, 2022
- DOI för MYCN induces cell-specific tumorigenic growth in RB1-proficient human retinal organoid and chicken retina models of retinoblastoma
- Ladda ner fulltext (pdf) av MYCN induces cell-specific tumorigenic growth in RB1-proficient human retinal organoid and chicken retina models of retinoblastoma
Aniridia with PAX6 mutations and narcolepsy

Ghaderi Berntsson, Shala; Kristoffersson, Anna; Daniilidou, Makrina; Dahl, Niklas et al.

Ingår i Journal of Sleep Research, 2020
- DOI för Aniridia with PAX6 mutations and narcolepsy
Brain Transcriptomics of Wild and Domestic Rabbits Suggests That Changes in Dopamine Signaling and Ciliary Function Contributed to Evolution of Tameness

Sato, Daiki X.; Rafati, Nima; Ring, Henrik; Younis, Shady et al.

Ingår i Genome Biology and Evolution, s. 1918-1928, 2020
- DOI för Brain Transcriptomics of Wild and Domestic Rabbits Suggests That Changes in Dopamine Signaling and Ciliary Function Contributed to Evolution of Tameness
Deletion in the Bardet-Biedl Syndrome Gene TTC8 Results in a Syndromic Retinal Degeneration in Dogs

Mäkeläinen, Suvi; Hellsand, Minas; van Der Heiden, Anna Darlene; Andersson, Elina et al.

Ingår i Genes, 2020
- DOI för Deletion in the Bardet-Biedl Syndrome Gene TTC8 Results in a Syndromic Retinal Degeneration in Dogs
- Ladda ner fulltext (pdf) av Deletion in the Bardet-Biedl Syndrome Gene TTC8 Results in a Syndromic Retinal Degeneration in Dogs
High-Resolution Imaging of Tumor Spheroids and Organoids Enabled by Expansion Microscopy

Edwards, Steven J.; Carannante, Valentina; Kuhnigk, Kyra; Ring, Henrik et al.

Ingår i Frontiers in Molecular Biosciences, 2020
- DOI för High-Resolution Imaging of Tumor Spheroids and Organoids Enabled by Expansion Microscopy
- Ladda ner fulltext (pdf) av High-Resolution Imaging of Tumor Spheroids and Organoids Enabled by Expansion Microscopy
Alpha 2-Adrenergic Receptor Agonist Brimonidine Stimulates ERK1/2 and AKT Signaling via Transactivation of EGF Receptors in the Human MIO-M1 Müller Cell Line

Harun-Or-Rashid, Mohammad; Hallböök, Finn

Ingår i Current Eye Research, s. 34-45, 2019
- DOI för Alpha 2-Adrenergic Receptor Agonist Brimonidine Stimulates ERK1/2 and AKT Signaling via Transactivation of EGF Receptors in the Human MIO-M1 Müller Cell Line
An ABCA4 loss-of-function mutation causes a canine form of Stargardt disease

Mäkeläinen, Suvi; Gòdia, Marta; Hellsand, Minas; Viluma, Agnese et al.

Ingår i PLOS Genetics, 2019
- DOI för An ABCA4 loss-of-function mutation causes a canine form of Stargardt disease
- Ladda ner fulltext (pdf) av An ABCA4 loss-of-function mutation causes a canine form of Stargardt disease
Changes in brain architecture are consistent with altered fear processing in domestic rabbits

Brusini, Irene; Carneiro, Miguel; Wang, Chunliang; Rubin, Carl-Johan et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 7380-7385, 2018
- DOI för Changes in brain architecture are consistent with altered fear processing in domestic rabbits
Zinc finger gene nolz1 regulates the formation of retinal progenitor cells and suppresses the Lim3/Lhx3 phenotype of retinal bipolar cells in chicken retina

Blixt, Maria K. E.; Konjusha, Dardan; Ring, Henrik; Hallböök, Finn

Ingår i Developmental Dynamics, s. 630-641, 2018
- DOI för Zinc finger gene nolz1 regulates the formation of retinal progenitor cells and suppresses the Lim3/Lhx3 phenotype of retinal bipolar cells in chicken retina
Heterogeneity in retinoblastoma: a tale of molecules and models

Stenfelt, Sonya; Blixt, Maria K. E.; All-Ericsson, Charlotta; Hallböök, Finn et al.

Ingår i CLINICAL AND TRANSLATIONAL MEDICINE, 2017
- DOI för Heterogeneity in retinoblastoma: a tale of molecules and models
- Ladda ner fulltext (pdf) av Heterogeneity in retinoblastoma: a tale of molecules and models
The evolution of Sex-linked barring alleles in chickens involves both regulatory and coding changes in CDKN2A

Thalmann, Doreen Schwochow; Ring, Henrik; Sundström, Elisabeth; Cao, Xiaofang et al.

Ingår i PLOS Genetics, 2017
- DOI för The evolution of Sex-linked barring alleles in chickens involves both regulatory and coding changes in CDKN2A
- Ladda ner fulltext (pdf) av The evolution of Sex-linked barring alleles in chickens involves both regulatory and coding changes in CDKN2A
A regulatory sequence from the retinoid X receptor gamma gene directs expression to horizontal cells and photoreceptors in the embryonic chicken retina

Blixt, Maria; Hallböök, Finn

Ingår i Molecular Vision, s. 1405-1420, 2016
Endothelin B Receptors on Primary Chicken Müller Cells and the Human MIO-M1 Müller Cell Line Activate ERK Signaling via Transactivation of Epidermal Growth Factor Receptors

Harun-Or-Rashid, Mohammad; Konjusha, Dardan; Galindo-Romero, Caridad; Hallböök, Finn

Ingår i PLOS ONE, 2016
- DOI för Endothelin B Receptors on Primary Chicken Müller Cells and the Human MIO-M1 Müller Cell Line Activate ERK Signaling via Transactivation of Epidermal Growth Factor Receptors
- Ladda ner fulltext (pdf) av Endothelin B Receptors on Primary Chicken Müller Cells and the Human MIO-M1 Müller Cell Line Activate ERK Signaling via Transactivation of Epidermal Growth Factor Receptors
Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease

Boije, Henrik; Fard, Shahrzad Shirazi; Edqvist, Per-Henrik; Hallböök, Finn

Ingår i Frontiers in Neuroanatomy, 2016
- DOI för Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease
- Ladda ner fulltext (pdf) av Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease
Lineage tracing of horizontal and photoreceptor cells in the embryonic chicken retina

Blixt, Maria; Hallböök, Finn

Ingår i Investigative Ophthalmology and Visual Science, 2016
Neuroprotection by α2-Adrenergic Receptor Stimulation after Excitotoxic Retinal Injury: A Study of the Total Population of Retinal Ganglion Cells and Their Distribution in the Chicken Retina

Galindo-Romero, Caridad; Harun-Or-Rashid, Mohammad; Jiménez-López, Manuel; Agudo-Barriuso, Manuel et al.

Ingår i PLOS ONE, 2016
- DOI för Neuroprotection by α2-Adrenergic Receptor Stimulation after Excitotoxic Retinal Injury: A Study of the Total Population of Retinal Ganglion Cells and Their Distribution in the Chicken Retina
- Ladda ner fulltext (pdf) av Neuroprotection by α2-Adrenergic Receptor Stimulation after Excitotoxic Retinal Injury: A Study of the Total Population of Retinal Ganglion Cells and Their Distribution in the Chicken Retina
A Genomic Duplication is Associated with Ectopic Eomesodermin Expression in the Embryonic Chicken Comb and Two Duplex-comb Phenotypes

Dorshorst, Ben; Harun-Or-Rashid, Mohammad; Bagherpoor, Alireza Jian; Rubin, Carl-Johan et al.

Ingår i PLOS Genetics, 2015
- DOI för A Genomic Duplication is Associated with Ectopic Eomesodermin Expression in the Embryonic Chicken Comb and Two Duplex-comb Phenotypes
- Ladda ner fulltext (pdf) av A Genomic Duplication is Associated with Ectopic Eomesodermin Expression in the Embryonic Chicken Comb and Two Duplex-comb Phenotypes
Adding another piece to the retinoblastoma puzzle

Blixt, Martin K. E.; Shirazi Fard, Shahrzad; All-Ericsson, C; Hallböök, Finn

Ingår i Cell Death and Disease, 2015
- DOI för Adding another piece to the retinoblastoma puzzle
- Ladda ner fulltext (pdf) av Adding another piece to the retinoblastoma puzzle
Alpha2-Adrenergic-Agonist Brimonidine Stimulates Negative Feedback and Attenuates Injury-Induced Phospho-ERK and Dedifferentiation of Chicken Müller Cells

Harun-Or-Rashid, Mohammad; Diaz-DelCastillo, Marta; Galindo-Romero, Caridad; Hallböök, Finn

Ingår i Investigative Ophthalmology and Visual Science, s. 5933-5945, 2015
- DOI för Alpha2-Adrenergic-Agonist Brimonidine Stimulates Negative Feedback and Attenuates Injury-Induced Phospho-ERK and Dedifferentiation of Chicken Müller Cells
- Ladda ner fulltext (pdf) av Alpha2-Adrenergic-Agonist Brimonidine Stimulates Negative Feedback and Attenuates Injury-Induced Phospho-ERK and Dedifferentiation of Chicken Müller Cells
The p53 co-activator Zac1 neither induces cell cycle arrest nor apoptosis in chicken Lim1 horizontal progenitor cells

Fard, Shahrzad Shirazi; Blixt, Maria; Hallböök, Finn

Ingår i Cell Death Discovery, 2015
- DOI för The p53 co-activator Zac1 neither induces cell cycle arrest nor apoptosis in chicken Lim1 horizontal progenitor cells
Whole Retinal Explants from Chicken Embryos for Electroporation and Chemical Reagent Treatments

Fard, Shahrzad Shirazi; Blixt, Maria; Hallböök, Finn

Ingår i Journal of Visualized Experiments, 2015
- DOI för Whole Retinal Explants from Chicken Embryos for Electroporation and Chemical Reagent Treatments
Specific spatial distribution of caspase-3 in normal lenses

Talebizadeh, Nooshin; Yu, Zhaohua; Martin, Kronschläger; Finn, Hallböök et al.

Ingår i Acta Ophthalmologica, s. 289-292, 2014
- DOI för Specific spatial distribution of caspase-3 in normal lenses
The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway

Fard, Shahrzad Shirazi; All-Ericsson, Charlotta; Hallböök, Finn

Ingår i Cell Cycle, s. 408-417, 2014
- DOI för The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway
The terminal basal mitosis of chicken retinal Lim1 horizontal cells is not sensitive to cisplatin-induced cell cycle arrest

Shirazi Fard, Shahrzad; Thyselius, Malin; All-Ericsson, Charlotta; Hallböök, Finn

Ingår i Cell Cycle, s. 3698-3706, 2014
- DOI för The terminal basal mitosis of chicken retinal Lim1 horizontal cells is not sensitive to cisplatin-induced cell cycle arrest
- Ladda ner fulltext (pdf) av The terminal basal mitosis of chicken retinal Lim1 horizontal cells is not sensitive to cisplatin-induced cell cycle arrest
Transactivation of EGF Receptors in Chicken Muller Cells by α2A-Adrenergic Receptors Stimulated by Brimonidine

Harun-Or-Rashid, Mohammad; Lindqvist, Niclas; Hallböök, Finn

Ingår i Investigative Ophthalmology and Visual Science, s. 3385-3394, 2014
- DOI för Transactivation of EGF Receptors in Chicken Muller Cells by α2A-Adrenergic Receptors Stimulated by Brimonidine
Alternative Splicing of the Chromodomain Protein Morf4l1 Pre-mRNA Has Implications on Cell Differentiation in the Developing Chicken Retina

Boije, Henrik; Ring, Henrik; Fard, Shahrzad Shirazi; Grundberg, Ida et al.

Ingår i Journal of Molecular Neuroscience, s. 615-628, 2013
- DOI för Alternative Splicing of the Chromodomain Protein Morf4l1 Pre-mRNA Has Implications on Cell Differentiation in the Developing Chicken Retina
Evolution of TUNEL-labeling in the Rat Lens After In Vivo Exposure to Just Above Threshold Dose UVB

Kronschläger, Martin; Yu, Zhaohua; Talebizadeh, Nooshin; Meyer, Linda M. et al.

Ingår i Current Eye Research, s. 880-885, 2013
- DOI för Evolution of TUNEL-labeling in the Rat Lens After In Vivo Exposure to Just Above Threshold Dose UVB
Forkheadbox N4 (FoxN4) triggers context-dependent differentiation in the developing chick retina and neural tube

Boije, Henrik; Shirazi Fard, S.; Ring, Henrik; Hallböök, Finn

Ingår i Differentiation, s. 11-19, 2013
- DOI för Forkheadbox N4 (FoxN4) triggers context-dependent differentiation in the developing chick retina and neural tube
Heterogenic Final Cell Cycle by Chicken Retinal Lim1 Horizontal Progenitor Cells Leads to Heteroploid Cells with a Remaining Replicated Genome

Fard, Shahrzad Shirazi; Jarrin, Miguel; Boije, Henrik; Fillon, Valerie et al.

Ingår i PLOS ONE, 2013
- DOI för Heterogenic Final Cell Cycle by Chicken Retinal Lim1 Horizontal Progenitor Cells Leads to Heteroploid Cells with a Remaining Replicated Genome
- Ladda ner fulltext (pdf) av Heterogenic Final Cell Cycle by Chicken Retinal Lim1 Horizontal Progenitor Cells Leads to Heteroploid Cells with a Remaining Replicated Genome
The expression of carnitine palmitoyl-CoA transferase-1B is influenced by a cis-acting eQTL in two chicken lines selected for high and low body weight

Ka, Sojeong; Markljung, Ellen; Ring, Henrik; Albert, Frank W et al.

Ingår i Physiological Genomics, s. 367-376, 2013
- DOI för The expression of carnitine palmitoyl-CoA transferase-1B is influenced by a cis-acting eQTL in two chicken lines selected for high and low body weight
GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium:

Ring, Henrik; Mendu, Suresh Kumar; Shirazi-Fard, Shahrzad; Birnir, Bryndis et al.

Ingår i PLOS ONE, 2012
- DOI för GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium:
- Ladda ner fulltext (pdf) av GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium:
Platelet-derived growth factor over-expression in retinal progenitors results in abnormal retinal vessel formation

Edqvist, Per-Henrik D; Niklasson, Mia; Vidal-Sanz, Manuel; Hallböök, Finn et al.

Ingår i PLOS ONE, 2012
- DOI för Platelet-derived growth factor over-expression in retinal progenitors results in abnormal retinal vessel formation
- Ladda ner fulltext (pdf) av Platelet-derived growth factor over-expression in retinal progenitors results in abnormal retinal vessel formation
Sonic Hedgehog-Signalling Patterns the Developing Chicken Comb as Revealed by Exploration of the Pea-comb Mutation

Boije, Henrik; Harun-Or-Rashid, Mohammad; Lee, Yu-Jen; Imsland, Freyja et al.

Ingår i PLOS ONE, 2012
- DOI för Sonic Hedgehog-Signalling Patterns the Developing Chicken Comb as Revealed by Exploration of the Pea-comb Mutation
- Ladda ner fulltext (pdf) av Sonic Hedgehog-Signalling Patterns the Developing Chicken Comb as Revealed by Exploration of the Pea-comb Mutation
The Rose-comb Mutation in Chickens Constitutes a Structural Rearrangement Causing Both Altered Comb Morphology and Defective Sperm Motility

Imsland, Freyja; Feng, Chungang; Boije, Henrik; Bed'hom, Bertrand et al.

Ingår i PLOS Genetics, 2012
- DOI för The Rose-comb Mutation in Chickens Constitutes a Structural Rearrangement Causing Both Altered Comb Morphology and Defective Sperm Motility
- Ladda ner fulltext (pdf) av The Rose-comb Mutation in Chickens Constitutes a Structural Rearrangement Causing Both Altered Comb Morphology and Defective Sperm Motility
A Complex Genomic Rearrangement Involving the Endothelin 3 Locus Causes Dermal Hyperpigmentation in the Chicken

Dorshorst, Ben; Molin, Anna-Maja; Rubin, Carl-Johan; Johansson, Anna M. et al.

Ingår i PLoS Genetics, 2011
- DOI för A Complex Genomic Rearrangement Involving the Endothelin 3 Locus Causes Dermal Hyperpigmentation in the Chicken
Differentially expressed genes in hypothalamus in relation to genomic regions under selection in two chicken lines resulting from divergent selection for high or low body weight

Ka, Sojeong; Albert, Frank W.; Denbow, D. Michael; Pääbo, Svante et al.

Ingår i Neurogenetics, s. 211-221, 2011
- DOI för Differentially expressed genes in hypothalamus in relation to genomic regions under selection in two chicken lines resulting from divergent selection for high or low body weight
Inactivation of Pmel Alters Melanosome Shape But Has Only a Subtle Effect on Visible Pigmentation

Hellström, Anders R.; Watt, Brenda; Fard, Shahrzad Shirazi; Tenza, Daniele et al.

Ingår i PLoS Genetics, 2011
- DOI för Inactivation of Pmel Alters Melanosome Shape But Has Only a Subtle Effect on Visible Pigmentation
Ptf1a/Rbpj complex inhibits ganglion cell fate and drives the specification of all horizontal cell subtypes in the chick retina

Lelièvre, E.C.; Lek, M.; Boije, H.; Houille-Vernes, L. et al.

Ingår i Developmental Biology, s. 296-308, 2011
- DOI för Ptf1a/Rbpj complex inhibits ganglion cell fate and drives the specification of all horizontal cell subtypes in the chick retina
Increased A-to-I RNA editing of the transcript for GABA_A receptor subunit α3 during chick retinal development

Ring, Henrik; Boije, Henrik; Daniel, Chammiran; Ohlson, Johan et al.

Ingår i Visual Neuroscience, s. 149-157, 2010
- DOI för Increased A-to-I RNA editing of the transcript for GABA_A receptor subunit α3 during chick retinal development
Multiple receptor tyrosine kinases are expressed in adult rat retinal ganglion cells as revealed by single-cell degenerate primer polymerase chain reaction

Lindqvist, Niclas; Lönngren, Ulrika; Agudo, Marta; Näpänkangas, Ulla et al.

Ingår i Upsala Journal of Medical Sciences, s. 65-80, 2010
- DOI för Multiple receptor tyrosine kinases are expressed in adult rat retinal ganglion cells as revealed by single-cell degenerate primer polymerase chain reaction
Pax2 Is Expressed in a Subpopulation of Muller Cells in the Central Chick Retina

Boije, Henrik; Ring, Henrik; Lopez-Gallardo, Meritxell; Prada, Carmen et al.

Ingår i Developmental Dynamics, s. 1858-1866, 2010
- DOI för Pax2 Is Expressed in a Subpopulation of Muller Cells in the Central Chick Retina
Whole genome resequencing reveals loci under selection during chicken domestication

Rubin, Carl-Johan; Zody, Michael C.; Eriksson, Jonas; Meadows, Jennifer et al.

Ingår i Nature, s. 587-591, 2010
- DOI för Whole genome resequencing reveals loci under selection during chicken domestication
Copy number variation in intron 1 of SOX5 causes the Pea-comb phenotype in chickens

Wright, Dominic; Boije, Henrik; Meadows, Jennifer; Bed'hom, Bertrand et al.

Ingår i PLoS Genetics, 2009
- DOI för Copy number variation in intron 1 of SOX5 causes the Pea-comb phenotype in chickens
Extremely different behaviours in high and low body weight lines of chicken are associated with differential expression of genes involved in neuronal plasticity

Ka, Sojeong; Lindberg, J.; Strömstedt, L.; Fitzsimmons, C. et al.

Ingår i Journal of neuroendocrinology, s. 208-216, 2009
- DOI för Extremely different behaviours in high and low body weight lines of chicken are associated with differential expression of genes involved in neuronal plasticity
Horizontal cell progenitors arrest in G2-phase and undergo terminal mitosis on the vitreal side of the chick retina

Boije, Henrik; Edqvist, Per-Henrik D.; Hallböök, Finn

Ingår i Developmental Biology, s. 105-113, 2009
- DOI för Horizontal cell progenitors arrest in G2-phase and undergo terminal mitosis on the vitreal side of the chick retina
Immediate Upregulation of Proteins Belonging to Different Branches of the Apoptotic Cascade in the Retina after Optic Nerve Transection and Optic Nerve Crush

Agudo, Marta; Perez-Marin, Maria Cruz; Sobrado-Calvo, Paloma; Lönngren, Ulrika et al.

Ingår i Investigative Ophthalmology and Visual Science, s. 424-431, 2009
- DOI för Immediate Upregulation of Proteins Belonging to Different Branches of the Apoptotic Cascade in the Retina after Optic Nerve Transection and Optic Nerve Crush
Proviral integrations and expression of endogenous Avian leucosis virus during long term selection for high and low body weight in two chicken lines

Ka, Sojeong; Kerje, Susanne; Bomold, Lina; Liljegren, Ulrika et al.

Ingår i Retrovirology, s. 68, 2009
- DOI för Proviral integrations and expression of endogenous Avian leucosis virus during long term selection for high and low body weight in two chicken lines
The Dominant white mutation in the PMEL17 gene does not cause visual impairment in chickens

Karlsson, Anna-Carin; Kerje, Susanne; Hallböök, Finn; Jensen, Per

Ingår i Veterinary Ophthalmology, s. 292-298, 2009
- DOI för The Dominant white mutation in the PMEL17 gene does not cause visual impairment in chickens
Axon-bearing and axon-less horizontal cell subtypes are generated consecutively during chick retinal development from progenitors that are sensitive to follistatin

Edqvist, Per-Henrik D; Lek, Madelen; Boije, Henrik; Lindbäck, Sarah M et al.

Ingår i BMC Developmental Biology, s. 46, 2008
- DOI för Axon-bearing and axon-less horizontal cell subtypes are generated consecutively during chick retinal development from progenitors that are sensitive to follistatin
Temporal and spatial expression of transcription factors FoxN4, Ptf1a, Prox1, Isl1 and Lim1 mRNA in the developing chick retina

Boije, Henrik; Edqvist, Per-Henrik D; Hallböök, Finn

Ingår i Gene Expression Patterns, s. 117-123, 2008
- DOI för Temporal and spatial expression of transcription factors FoxN4, Ptf1a, Prox1, Isl1 and Lim1 mRNA in the developing chick retina
The amphioxus genome illuminates vertebrate origins and cephalochordate biology

Holland, Linda Z; Albalat, Ricard; Azumi, Kaoru; Benito-Gutiérrez, Elia et al.

Ingår i Genome Research, s. 1100-1111, 2008
- DOI för The amphioxus genome illuminates vertebrate origins and cephalochordate biology
Time course profiling of the retinal transcriptome after optic nerve transection and optic nerve crush

Agudo, Marta; Pérez-Marín, Maria Cruz; Lönngren, Ulrika; Sobrado, Paloma et al.

Ingår i Molecular Vision, s. 1050-1063, 2008
Differential, age-dependent MEK-ERK and PI3K-Akt activation by insulin acting as a survival factor during embryonic retinal development

Chavarría, Teresa; Valenciano, Ana I.; Mayordomo, Raquel; Egea, Joaquim et al.

Ingår i Developmental Neurobiology, s. 1777-1788, 2007
- DOI för Differential, age-dependent MEK-ERK and PI3K-Akt activation by insulin acting as a survival factor during embryonic retinal development
Neurotransmitter phenotype-specific expression changes in developing sympathetic neurons

Apostolova, Galina; Dorn, Roland; Ka, Sojeong; Hallböök, Finn et al.

Ingår i Molecular and Cellular Neuroscience, s. 397-408, 2007
- DOI för Neurotransmitter phenotype-specific expression changes in developing sympathetic neurons
A genomic view of the sea urchin nervous system

Burke, R D; Angerer, L M; Elphick, M R; Humphrey, G W et al.

Ingår i Developmental Biology, s. 434-460, 2006
- DOI för A genomic view of the sea urchin nervous system
Conserved Synteny Between the Ciona Genome and Human Paralogons Identifies Large Duplication Events in the Molecular Evolution of the Insulin-Relaxin Gene Family

Olinski, Robert; Lundin, Lars-Gustav; Hallböök, Finn

Ingår i Molecular biology and evolution, s. 10-22, 2006
- DOI för Conserved Synteny Between the Ciona Genome and Human Paralogons Identifies Large Duplication Events in the Molecular Evolution of the Insulin-Relaxin Gene Family
Early identification of retinal subtypes in the developing, pre-laminated chick retina using the transcription factors Prox1, Lim1, Ap2α, Pax6, Isl1, Isl2, Lim3 and Chx10

Edqvist, Per-Henrik; Myers, Sarah; Hallböök, Finn

Ingår i European journal of histochemistry, s. 147-154, 2006
Formation and evolution of the chordate neurotrophin and Trk receptor genes.

Hallbook, Finn; Wilson, Karen; Thorndyke, Mike; Olinski, Robert

Ingår i Brain Behav Evol, s. 133-44, 2006
Formation and evolution of the chordate neurotrophin and Trk receptor genes

Hallböök, Finn; Wilson, Karen; Thorndyke, Mike; Olinski, Robert Piotr

Ingår i Brain, behavior, and evolution, s. 133-144, 2006
- DOI för Formation and evolution of the chordate neurotrophin and Trk receptor genes
The genome of the sea urchin Strongylocentrotus purpuratus

Sodergren, Erica; Weinstock, George M.; Davidson, Eric H.; Cameron, R. Andrew et al.

Ingår i Science, s. 941-952, 2006
- DOI för The genome of the sea urchin Strongylocentrotus purpuratus
Three insulin-relaxin-like genes in Ciona intestinalis

Olinski, Robert; Dahlberg, Carl; Thorndyke, Mike; Hallböök, Finn

Ingår i Peptides, s. 2535-2546, 2006
- DOI för Three insulin-relaxin-like genes in Ciona intestinalis
Expression analysis of growth and energy regulation-associated genes in two divergent chicken strains.

Ka, Sojeong; Fitzsimmons, Carolyn; Jacobsson, Lina; Savolainen, Peter et al.

Ingår i Ann N Y Acad Sci, s. 357-9, 2005
Genome duplication-driven evolution of gene families: insights from the formation of the insulin family

Olinski, Robert; Lundin, Lars-Gustav; Hallböök, Finn

Ingår i Ann N Y Acad Sci, s. 426-428, 2005
GDNF, Ret, GFRalpha1 and 2 in the adult rat retino-tectal system after optic nerve transection

Lindqvist, Niclas; Peinado-Ramon, Paloma; Vidal-Sanz, Manuel; Hallbook, Finn

Ingår i Experimental Neurology, s. 487-489, 2004
GDNF, Ret, GFRα1 and 2 in the adult rat retino-tectal system after optic nerve transection

Lindqvist, Niclas; Peinado-Ramoón, Paloma; Vidal-Sanz, Manuel; Hallböök, Finn

Ingår i Experimental Neurology, s. 487-499, 2004
- DOI för GDNF, Ret, GFRα1 and 2 in the adult rat retino-tectal system after optic nerve transection
Newborn horizontal cells migrate bi-directionally across the neuroepithelium during retinal development

Edqvist, Per-Henrik; Hallbook, Finn

Ingår i Development, s. 1343-1251, 2004
An Improved Cell Culture Model Based on 2/4/A1 Cell Monolayers for Studies of Intestinal Drug Transport

Tavelin, Staffan; Taipalensuu, Jan; Hallböök, Finn; Vellonen, Kati-Sisko et al.

Ingår i Pharmaceutical research, s. 373-381, 2003
- DOI för An Improved Cell Culture Model Based on 2/4/A1 Cell Monolayers for Studies of Intestinal Drug Transport
An improved cell culture model based on 2/4/A1 cell monolayers for studies of intestinal drug transport: characterization of transport routes

Tavelin, Staffan; Taipalensuu, Jan; Hallböök, Finn; Vellonen, Kati-Sisko et al.

Ingår i Pharmaceutical research, s. 373-381, 2003
- DOI för An improved cell culture model based on 2/4/A1 cell monolayers for studies of intestinal drug transport: characterization of transport routes
Generation of retinal ganglion cells is modulated by caspase-dependent programmed cell death

Mayordomo, Raquel; Valenciano, Ana; Rosa de la, Enrique; Hallböök, Finn

Ingår i European Journal of Neuroscience, s. 1744-1750, 2003
- DOI för Generation of retinal ganglion cells is modulated by caspase-dependent programmed cell death
Numerous groups of chromosomal regional paralogies strongly indicate two genome doublings at the root of the vertebrates

Lundin, Lars-Gustav; Larhammar, Dan; Hallböök, Finn

Ingår i Journal of Structural and Functional Genomics, s. 53-63, 2003
- DOI för Numerous groups of chromosomal regional paralogies strongly indicate two genome doublings at the root of the vertebrates
Proopiomelanocortin and melanocortin receptors in the adult rat retino-tectal system and their regulation after optic nerve transection

Lindqvist, Niclas; Näpänkangas, Ulla; Lindblom, Jonas; Hallböök, Finn

Ingår i European Journal of Pharmacology, s. 85-94, 2003
- DOI för Proopiomelanocortin and melanocortin receptors in the adult rat retino-tectal system and their regulation after optic nerve transection
Rat retinal ganglion cells upregulate the pro-apoptotic BH3-only protein Bim after optic nerve transection

Näpänkangas, Ulla; Lindqvist, Niclas; Lindholm, Dan; Hallböök, Finn

Ingår i Brain Research. Molecular Brain Research, s. 30-37, 2003
- DOI för Rat retinal ganglion cells upregulate the pro-apoptotic BH3-only protein Bim after optic nerve transection
Biotin decreases retinal apoptosis and induces eye malformations in the early chick embryo

Valenciano, Ana; Mayordomo, Raquel; de la Rosa, Enrique; Hallböök, Finn

Ingår i NeuroReport, s. 297-299, 2002
Overlapping and specific patterns of GDNF, c-ret and GFR mRNA expression in the developing chicken retina

Karlsson, Miriam; Lindqvist, Niclas; Mayordomo, Raquel; Hallböök, Finn

Ingår i Mechanisms of Development, s. 161-165, 2002
- DOI för Overlapping and specific patterns of GDNF, c-ret and GFR mRNA expression in the developing chicken retina
The human hox-bearing chromosome regions did arise by block or chromosome (or even genome) duplications

Larhammar, Dan; Lundin, Lars-Gustav; Hallböök, Finn

Ingår i Genome Research, s. 1910-1920, 2002
- DOI för The human hox-bearing chromosome regions did arise by block or chromosome (or even genome) duplications
Nerve growth factor is expressed by postmitotic avian retinal horizontal cells and supports their survival during development in an autocrine mode of action

Karlsson, Miriam; Mayordomo, Raquel; Reichardt, Louis; Catsicas, Stefan et al.

Ingår i Development, s. 471-479, 2001
Analysis of subcellular location of bestrophin in transfected RPE cell lines

Bakall, Benjamin; Mayordomo, Raquel; Hallböök, Finn; Wadelius, Claes

Ingår i Gene Function and Disease, s. 128-133, 2000
- DOI för Analysis of subcellular location of bestrophin in transfected RPE cell lines
Gene functional analysis in nervous system

Hallböök, Finn; Catsicas, M; Staple, J K; Grenningloh, G et al.

Ingår i Methods in Enzymology, s. 148-167, 2000
- DOI för Gene functional analysis in nervous system
Gene functional analysis in the nervous system

Hallböök, Finn; Catsicas, M; Staple, JK; Grenningloh, G et al.

Ingår i Methods in Enzymology, s. 148-167, 2000
- DOI för Gene functional analysis in the nervous system
Evolution of the vertebrate neurotrophin and Trk receptor gene families

Hallböök, Finn

Ingår i Current Opinion in Neurobiology, s. 616-621, 1999
- DOI för Evolution of the vertebrate neurotrophin and Trk receptor gene families
Evolution of the vertebrate neurotrophin and Trk receptor gene families

Hallböök, Finn

Ingår i Current Opinion in Neurobiology, s. 616-621, 1999
- DOI för Evolution of the vertebrate neurotrophin and Trk receptor gene families
Kainic acid, tetrodotoxin and light modulate expression of brain-derived neurotrophic factor in developing avian retinal ganglion cells and their tectal target

Karlsson, Miriam; Hallböök, Finn

Ingår i Neuroscience, s. 137-150, 1998
- DOI för Kainic acid, tetrodotoxin and light modulate expression of brain-derived neurotrophic factor in developing avian retinal ganglion cells and their tectal target
Lampetra fluviatilis neurotrophin homolog, descendant of a neurotrophin ancestor, discloses the early molecular evolution of neurotrophins in the vertebrate subphylum

Hallböök, Finn; Lundin, Lars-Gustav; Kullander, Klas

Ingår i Journal of Neuroscience, s. 8700-8711, 1998
MAP kinase phosphatase-1 mRNA is expressed in embryonic sympathetic neurons and is upregulated after NGF stimulation

Peinado-Ramón, Paloma; Wallén, Åsa; Hallböök, Finn

Ingår i Brain Research. Molecular Brain Research, s. 256-267, 1998
- DOI för MAP kinase phosphatase-1 mRNA is expressed in embryonic sympathetic neurons and is upregulated after NGF stimulation
Nerve growth factor receptor TrkA is expressed by horizontal and amacrine cells during chicken retinal development

Karlsson, Miriam; Clary, D; Lefcort, F; Reichardt, L et al.

Ingår i J. Comp. Neurol., s. 408-416, 1998
- DOI för Nerve growth factor receptor TrkA is expressed by horizontal and amacrine cells during chicken retinal development
Nerve growth factor receptor TrkA is expressed by horizontal and amacrine cells during chicken retinal development

Karlsson, Miriam; Clary, D O; Lefcort, F B; Reichardt, L F et al.

Ingår i Journal of Comparative Neurology, s. 408-416, 1998
- DOI för Nerve growth factor receptor TrkA is expressed by horizontal and amacrine cells during chicken retinal development
Characterization and evaluation of antisense oligonucleotides: inhibition of NGF synthesis in transfected COS cells

Hallböök, Finn; Sahlén, Anders; Catsicas, S

Ingår i Antisense and Nucleic Acid Drug Development, s. 89-100, 1997
- DOI för Characterization and evaluation of antisense oligonucleotides: inhibition of NGF synthesis in transfected COS cells
Distribution of BDNF and trkB mRNA in the otic region of 3.5 and 4.5 day chick embryos as revealed with a combination of in situ hybridization and tract tracing

Hallböök, Finn; Fritzsch, B

Ingår i International Journal of Developmental Biology, s. 725-732, 1997
Expression of neurotrophins and Trk receptors in the developing, adult, and regenerating avian cochlea

Pirvola, U; Hallböök, Finn; Xing-Qun, L; Virkkala, J et al.

Ingår i Journal of Neurobiology, s. 1019-1033, 1997
- DOI för Expression of neurotrophins and Trk receptors in the developing, adult, and regenerating avian cochlea
Human mast cells express functional TrkA and are a source of nerve growth factor

Nilsson, Gunnar; Forsberg-Nilsson, Karin; Xiang, Z; Hallböök, Finn et al.

Ingår i European Journal of Immunology, s. 2295-2301, 1997
- DOI för Human mast cells express functional TrkA and are a source of nerve growth factor
Molecular phylogeny and evolution of the neurotrophins from monotremes and marsupials

Kullander, Klas; Carlsson, Barbro; Hallböök, Finn

Ingår i Journal of Molecular Evolution, s. 311-321, 1997
- DOI för Molecular phylogeny and evolution of the neurotrophins from monotremes and marsupials
A simple and reliable technique to combine oligonucleotide probe in situ hybridization with neuronal tract tracing in vertebrate embryos.

Fritzsch, B; Hallböök, F

Ingår i Biotechnic & Histochemistry, s. 289-94, 1996
Expression of neurotrophins and trk receptors in the avian retina

Hallböök, Finn; Bäckström, Anders; Kullander, Klas; Ebendal, Ted et al.

Ingår i Journal of Comparative Neurology, s. 664-676, 1996
- DOI för Expression of neurotrophins and trk receptors in the avian retina
Developmentally-regulated expression of mRNA for neurotrohin high-affinity (trk) receptors within chich trigeminal sensory neurons

Williams, R; Bäckström, Anders; Kullander, Klas; Hallböök, Finn et al.

Ingår i European Journal of Neuroscience, s. 116-128, 1995
Neurotrophins and their receptors in chicken neuronal development

Hallböök, Finn; Bäckström, Anders; Kullander, Klas; Kylberg, Annika et al.

Ingår i International Journal of Developmental Biology, s. 855-868, 1995
Differential actions of neurotrophins in the locus coeruleus and basal forebrain.

Friedman, W J; Ibáñez, C F; Hallböök, F; Persson, H et al.

Ingår i Experimental Neurology, s. 72-8, 1993
- DOI för Differential actions of neurotrophins in the locus coeruleus and basal forebrain.
Expression of neurotrophin-4 mRNA during oogenesis in Xenopus laevis.

Ibáñez, C F; Hallböök, F; Godeau, F; Persson, H

Ingår i International Journal of Developmental Biology, s. 239-45, 1992
Distinct functions for thyroid hormone receptors alpha and beta in brain development indicated by differential expression of receptor genes.

Forrest, D; Hallböök, F; Persson, H; Vennström, B

Ingår i EMBO Journal, s. 269-75, 1991
Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary.

Hallböök, F; Ibáñez, C F; Persson, H

Ingår i Neuron, s. 845-58, 1991

Tillhör forskningsområden

Neuroonkologi och neurodegeneration