Publications

Tumour acidosis remodels the glycocalyx to control lipid scavenging and ferroptosis

Bang-Rudenstam, Anna; Cerezo-Magana, Myriam; Horvath, Marton; Talbot, Hugo et al.

Part of Nature Cell Biology, p. 567-580, 2026

• DOI for Tumour acidosis remodels the glycocalyx to control lipid scavenging and ferroptosis
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Heparan sulfate N-deacetylase/N-sulfotransferase-1 regulates glioblastoma cell migration and invasion

Spyrou, Argyris; Roy, Ananya; Xiong, Anqi; Kundu, Soumi et al.

Part of Matrix Biology, p. 1-15, 2025

• DOI for Heparan sulfate N-deacetylase/N-sulfotransferase-1 regulates glioblastoma cell migration and invasion

Loss of NDST1 N-sulfotransferase activity is associated with autosomal recessive intellectual disability

Khosrowabadi, Elham; Mignon-Ravix, Cécile; Riccardi, Florence; Cacciagli, Pierre et al.

Part of Human Molecular Genetics, p. 520-529, 2024

• DOI for Loss of NDST1 N-sulfotransferase activity is associated with autosomal recessive intellectual disability

Landscape of mast cell populations across organs in mice and humans

Tauber, Marie; Basso, Lilian; Martin, Jeremy; Bostan, Luciana et al.

Part of Journal of Experimental Medicine, 2023

• DOI for Landscape of mast cell populations across organs in mice and humans

Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics

Noborn, Fredrik; Nilsson, Jonas; Sihlbom, Carina; Nikpour, Mahnaz et al.

Part of Molecular & Cellular Proteomics, 2023

• DOI for Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics
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A dominant negative splice variant of the heparan sulfate biosynthesis enzyme NDST1 reduces heparan sulfate sulfation

Missaghian, Parisa; Dierker, Tabea; Khosrowabadi, Elham; Axling, Fredrik et al.

Part of Glycobiology, p. 518-528, 2022

• DOI for A dominant negative splice variant of the heparan sulfate biosynthesis enzyme NDST1 reduces heparan sulfate sulfation
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Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development

Habicher, Judith; Varshney, Gaurav K.; Waldmann, Laura; Snitting, Daniel et al.

Part of PLOS Genetics, 2022

• DOI for Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development
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Heparan Sulfate Biosynthesis in Zebrafish

Gorniok, Beata Filipek; Habicher, Judith; Ledin, Johan; Kjellén, Lena

Part of Journal of Histochemistry and Cytochemistry, p. 49-60, 2021

• DOI for Heparan Sulfate Biosynthesis in Zebrafish

Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate

Bachvarova, Velina; Dierker, Tabea; Esko, Jeffrey; Hoffmann, Daniel et al.

Part of Matrix Biology, p. 43-59, 2020

• DOI for Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate
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Establishment and characterization of Drosophila cell lines mutant for heparan sulfate modifying enzymes

Nakato, Eriko; Liu, Xin; Eriksson, Inger; Yamamoto, Maki et al.

Part of Glycobiology, p. 479-489, 2019

• DOI for Establishment and characterization of Drosophila cell lines mutant for heparan sulfate modifying enzymes

Expanding the chondroitin glycoproteome of Caenorhabditis elegans

Noborn, Fredrik; Toledo, Alejandro Gomez; Nasir, Waqas; Nilsson, Jonas et al.

Part of Journal of Biological Chemistry, p. 379-389, 2018

• DOI for Expanding the chondroitin glycoproteome of Caenorhabditis elegans

Mitogen-Activated Protein Kinase Signaling Regulates Proteoglycan Composition of Mast Cell Secretory Granules

Frisk, Jun Mei Hu; Kjellén, Lena; Melo, Fabio R.; Öhrvik, Helena et al.

Part of Frontiers in Immunology, 2018

• DOI for Mitogen-Activated Protein Kinase Signaling Regulates Proteoglycan Composition of Mast Cell Secretory Granules
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Specificity of glycosaminoglycan-protein interactions

Kjellén, Lena; Lindahl, Ulf

Part of Current opinion in structural biology, p. 101-108, 2018

• DOI for Specificity of glycosaminoglycan-protein interactions

Copper Regulates Maturation and Expression of an MITF: Tryptase Axis in Mast Cells

Hu Frisk, Jun Mei; Kjellén, Lena; Kaler, Stephen G; Pejler, Gunnar et al.

Part of Journal of Immunology, p. 4132-4141, 2017

• DOI for Copper Regulates Maturation and Expression of an MITF: Tryptase Axis in Mast Cells

Heparanase confers a growth advantage to differentiating murine embryonic stem cells, and enhances oligodendrocyte formation.

Xiong, Anqi; Kundu, Soumi; Forsberg, Maud; Xiong, Yuyuan et al.

Part of Matrix Biology, p. 92-104, 2017

• DOI for Heparanase confers a growth advantage to differentiating murine embryonic stem cells, and enhances oligodendrocyte formation.

Identification of novel chondroitin sulfate sulfotransferases and proteoglycan core proteins in the nematode C. elegans

Dierker, Tabea; Noborn, F.; Hinas, Andrea; Kjellén, Lena

Part of International journal of experimental pathology (Print), 2017

Separation and Purification of Glycosaminoglycans (GAGs) from Caenorhabditis elegans

Dierker, Tabea; Kjellén, Lena

Part of Bio-protocol, 2017

• DOI for Separation and Purification of Glycosaminoglycans (GAGs) from Caenorhabditis elegans

Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones

Dierker, Tabea; Bachvarova, Velina; Krause, Yvonne; Li, Jin-Ping et al.

Part of Matrix Biology, p. 82-92, 2016

• DOI for Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones

Metastasis Stimulation by Hypoxia and Acidosis-Induced Extracellular Lipid Uptake Is Mediated by Proteoglycan-Dependent Endocytosis

Menard, Julien A.; Christianson, Helena C.; Kucharzewska, Paulina; Bourseau-Guilmain, Erika et al.

Part of Cancer Research, p. 4828-4840, 2016

• DOI for Metastasis Stimulation by Hypoxia and Acidosis-Induced Extracellular Lipid Uptake Is Mediated by Proteoglycan-Dependent Endocytosis

NDST2 (N-Deacetylase/N-Sulfotransferase-2) Enzyme Regulates Heparan Sulfate Chain Length

Deligny, Audrey; Dierker, Tabea; Dagälv, Anders; Lundequist, Anders et al.

Part of Journal of Biological Chemistry, p. 18600-18607, 2016

• DOI for NDST2 (N-Deacetylase/N-Sulfotransferase-2) Enzyme Regulates Heparan Sulfate Chain Length

Nematodes join the family of chondroitin sulfate-synthesizing organisms: Identification of an active chondroitin sulfotransferase in Caenorhabditis elegans

Dierker, Tabea; Shao, Chun; Haitina, Tatjana; Zaia, Joseph et al.

Part of Scientific Reports, 2016

• DOI for Nematodes join the family of chondroitin sulfate-synthesizing organisms: Identification of an active chondroitin sulfotransferase in Caenorhabditis elegans
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Serglycin proteoglycans limit enteropathy in Trichinella spiralis-infected mice

Roy, Ananya; Sawesi, Osama; Pettersson, Ulrika A.; Dagälv, Anders et al.

Part of BMC Immunology, 2016

• DOI for Serglycin proteoglycans limit enteropathy in Trichinella spiralis-infected mice
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Versican accumulates in vascular lesions in pulmonary arterial hypertension

Chang, Ya-Ting; Chan, Christina K.; Eriksson, Inger; Johnson, Pamela Y. et al.

Part of PULMONARY CIRCULATION, p. 347-359, 2016

• DOI for Versican accumulates in vascular lesions in pulmonary arterial hypertension

Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans

Öhrvik, Helena; Logeman, Brandon; Noguchi, Glyn; Eriksson, Inger et al.

Part of Journal of Immunology, p. 3654-3664, 2015

• DOI for Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans
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Identification of Chondroitin Sulfate Linkage Region Glycopeptides Reveals Prohormones as a Novel Class of Proteoglycans

Noborn, Fredrik; Toledo, Alejandro Gomez; Sihlbom, Carina; Lengqvist, Johan et al.

Part of Molecular & Cellular Proteomics, p. 41-49, 2015

• DOI for Identification of Chondroitin Sulfate Linkage Region Glycopeptides Reveals Prohormones as a Novel Class of Proteoglycans

Profiling sulfation/epimerization pattern of full-length heparan sulfate by NMR following cell culture C-13-glucose metabolic labeling

Pegeot, Mathieu; Sadir, Rabia; Eriksson, Inger; Kjellén, Lena et al.

Part of Glycobiology, p. 151-156, 2015

• DOI for Profiling sulfation/epimerization pattern of full-length heparan sulfate by NMR following cell culture C-13-glucose metabolic labeling

The Ndst Gene Family in Zebrafish: Role of Ndst1b in Pharyngeal Arch Formation

Filipek-Gorniok, Beata; Carlsson, Pernilla; Haitina, Tatjana; Habicher, Judith et al.

Part of PLOS ONE, 2015

• DOI for The Ndst Gene Family in Zebrafish: Role of Ndst1b in Pharyngeal Arch Formation
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Mast Cell Chymase Degrades the Alarmins Heat Shock Protein 70, Biglycan, HMGB1, and Interleukin-33 (IL-33) and Limits Danger-induced Inflammation

Roy, Ananya; Ganesh, Goutham; Sippola, Helena; Bolin, Sara et al.

Part of Journal of Biological Chemistry, p. 237-250, 2014

• DOI for Mast Cell Chymase Degrades the Alarmins Heat Shock Protein 70, Biglycan, HMGB1, and Interleukin-33 (IL-33) and Limits Danger-induced Inflammation

Dimerized Glycosaminoglycan Chains Increase FGF Signaling during Zebrafish Development

Nguyen, Thao K. N.; Tran, Vy M.; Sorna, Venkataswamy; Eriksson, Inger et al.

Part of ACS Chemical Biology, p. 939-948, 2013

• DOI for Dimerized Glycosaminoglycan Chains Increase FGF Signaling during Zebrafish Development

Distorted Secretory Granule Composition in Mast Cells with Multiple Protease Deficiency

Grujic, Mirjana; Calounova, Gabriela; Eriksson, Inger; Feyerabend, Thorsten et al.

Part of Journal of Immunology, p. 3931-3938, 2013

• DOI for Distorted Secretory Granule Composition in Mast Cells with Multiple Protease Deficiency

Expression of chondroitin/dermatan sulfate glycosyltransferases during early zebrafish development

Filipek-Gorniok, Beata; Holmborn, Katarina; Haitina, Tatjana; Habicher, Judith et al.

Part of Developmental Dynamics, p. 964-975, 2013

• DOI for Expression of chondroitin/dermatan sulfate glycosyltransferases during early zebrafish development

MicroRNA-24 Suppression of N-Deacetylase/N-Sulfotransferase-1 (NDST1) Reduces Endothelial Cell Responsiveness to Vascular Endothelial Growth Factor A (VEGFA)

Kasza, Zsolt; Fredlund Fuchs, Peder; Tamm, Christoffer; Eriksson, Anna S. et al.

Part of Journal of Biological Chemistry, p. 25956-25963, 2013

• DOI for MicroRNA-24 Suppression of N-Deacetylase/N-Sulfotransferase-1 (NDST1) Reduces Endothelial Cell Responsiveness to Vascular Endothelial Growth Factor A (VEGFA)

Pathophysiology of heparan sulphate: many diseases, few drugs

Lindahl, Ulf; Kjellén, Lena

Part of Journal of Internal Medicine, p. 555-571, 2013

• DOI for Pathophysiology of heparan sulphate: many diseases, few drugs
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Functional Overlap Between Chondroitin and Heparan Sulfate Proteoglycans During VEGF-Induced Sprouting Angiogenesis

Le Jan, Sébastien; Hayashi, Makoto; Kasza, Zsolt; Eriksson, Inger et al.

Part of Arteriosclerosis, Thrombosis and Vascular Biology, p. 1255-1263, 2012

• DOI for Functional Overlap Between Chondroitin and Heparan Sulfate Proteoglycans During VEGF-Induced Sprouting Angiogenesis

Glycobiology: Enzyme deficiencies deciphered

Kjellén, Lena

Part of Nature chemical biology, p. 137-138, 2012

• DOI for Glycobiology: Enzyme deficiencies deciphered

Heparan Sulfate Biosynthesis Enzymes in Embryonic Stem Cell Biology

Tamm, Christoffer; Kjellén, Lena; Li, Jin-Ping

Part of Journal of Histochemistry and Cytochemistry, p. 943-949, 2012

• DOI for Heparan Sulfate Biosynthesis Enzymes in Embryonic Stem Cell Biology

Heparan Sulfate Biosynthesis: Regulation and Variability

Kreuger, Johan; Kjellén, Lena

Part of Journal of Histochemistry and Cytochemistry, p. 898-907, 2012

• DOI for Heparan Sulfate Biosynthesis: Regulation and Variability

Heparin biosynthesis

Carlsson, Pernilla; Kjellén, Lena

Part of Handbook of experimental pharmacology, p. 23-41, 2012

• DOI for Heparin biosynthesis

Undersulfation of Heparan Sulfate Restricts Differentiation Potential of Mouse Embryonic Stem Cells

Forsberg, Maud; Holmborn, Katarina; Kundu, Soumi; Dagälv, Anders et al.

Part of Journal of Biological Chemistry, p. 10853-10862, 2012

• DOI for Undersulfation of Heparan Sulfate Restricts Differentiation Potential of Mouse Embryonic Stem Cells

Lowered Expression of Heparan Sulfate/Heparin Biosynthesis Enzyme N-Deacetylase/N-Sulfotransferase 1 Results in Increased Sulfation of Mast Cell Heparin

Dagälv, Anders; Holmborn, Katarina; Kjellén, Lena; Åbrink, Magnus

Part of Journal of Biological Chemistry, p. 44433-44440, 2011

• DOI for Lowered Expression of Heparan Sulfate/Heparin Biosynthesis Enzyme N-Deacetylase/N-Sulfotransferase 1 Results in Increased Sulfation of Mast Cell Heparin

Mucopolysaccharidosis Type I, Unique Structure of Accumulated Heparan Sulfate and Increased N-Sulfotransferase Activity in Mice Lacking alpha-L-iduronidase

Holley, Rebecca J.; Deligny, Audrey; Wei, Wei; Watson, H. Angharad et al.

Part of Journal of Biological Chemistry, p. 37515-37524, 2011

• DOI for Mucopolysaccharidosis Type I, Unique Structure of Accumulated Heparan Sulfate and Increased N-Sulfotransferase Activity in Mice Lacking alpha-L-iduronidase

Mesomelia-Synostoses Syndrome Results from Deletion of SULF1 and SLCO5A1 Genes at 8q13

Isidor, Bertrand; Pichon, Olivier; Redon, Richard; Day-Salvatore, Debra et al.

Part of American Journal of Human Genetics, p. 95-100, 2010

• DOI for Mesomelia-Synostoses Syndrome Results from Deletion of SULF1 and SLCO5A1 Genes at 8q13

Mice deficient in heparan sulfate N-deacetylase/N-sulfotransferase 1.

Ringvall, Maria; Kjellén, Lena

Part of Progress in molecular biology and translational science, p. 35-58, 2010

• DOI for Mice deficient in heparan sulfate N-deacetylase/N-sulfotransferase 1.

Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation

Presto, Jenny; Thuveson, Maria; Carlsson, Pernilla; Busse, Marta et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 4751-4756, 2008

• DOI for Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation

Heparin/heparan sulfate biosynthesis: Processive formation of N-sulfated domains

Carlsson, Pernilla; Presto, Jenny; Spillmann, Dorothe; Lindahl, Ulf et al.

Part of Journal of Biological Chemistry, p. 20008-20014, 2008

• DOI for Heparin/heparan sulfate biosynthesis: Processive formation of N-sulfated domains

Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization

Kawamura, Harukiyo; Li, Xiujuan; Goishi, Katsutoshi; van Meeteren, Laurens A et al.

Part of Blood, p. 3638-49, 2008

• DOI for Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization

Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation

Busse, Marta; Feta, Almir; Presto, Jenny; Wilén, Maria et al.

Part of Journal of Biological Chemistry, p. 32802-32810, 2007

• DOI for Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation

Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development

Abramsson, Alexandra; Kurup, Sindhulakshmi; Yamada, Shuhei; Lindblom, Per et al.

Part of Genes & Development, p. 316-331, 2007

• DOI for Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development

Enzymatically active N-deacetylase/N-sulfotransferase-2 is present in liver but does not contribute to heparan sulfate N-sulfation

Ledin, Johan; Ringvall, Maria; Thuveson, Maria; Eriksson, Inger et al.

Part of Journal of Biological Chemistry, p. 35727-35734, 2006

• DOI for Enzymatically active N-deacetylase/N-sulfotransferase-2 is present in liver but does not contribute to heparan sulfate N-sulfation

Heparan sulfate in trans potentiates VEGFR-mediated angiogenesis

Jakobsson, Lars; Kreuger, Johan; Holmborn, Katarina; Lundin, Lars et al.

Part of Developmental Cell, p. 625-634, 2006