Publikationer

Tumour acidosis remodels the glycocalyx to control lipid scavenging and ferroptosis

Bang-Rudenstam, Anna; Cerezo-Magana, Myriam; Horvath, Marton; Talbot, Hugo et al.

Ingår i Nature Cell Biology, s. 567-580, 2026

• DOI för Tumour acidosis remodels the glycocalyx to control lipid scavenging and ferroptosis
• Ladda ner fulltext (pdf) av Tumour acidosis remodels the glycocalyx to control lipid scavenging and ferroptosis

Heparan sulfate N-deacetylase/N-sulfotransferase-1 regulates glioblastoma cell migration and invasion

Spyrou, Argyris; Roy, Ananya; Xiong, Anqi; Kundu, Soumi et al.

Ingår i Matrix Biology, s. 1-15, 2025

• DOI för Heparan sulfate N-deacetylase/N-sulfotransferase-1 regulates glioblastoma cell migration and invasion

Loss of NDST1 N-sulfotransferase activity is associated with autosomal recessive intellectual disability

Khosrowabadi, Elham; Mignon-Ravix, Cécile; Riccardi, Florence; Cacciagli, Pierre et al.

Ingår i Human Molecular Genetics, s. 520-529, 2024

• DOI för Loss of NDST1 N-sulfotransferase activity is associated with autosomal recessive intellectual disability

Landscape of mast cell populations across organs in mice and humans

Tauber, Marie; Basso, Lilian; Martin, Jeremy; Bostan, Luciana et al.

Ingår i Journal of Experimental Medicine, 2023

• DOI för Landscape of mast cell populations across organs in mice and humans

Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics

Noborn, Fredrik; Nilsson, Jonas; Sihlbom, Carina; Nikpour, Mahnaz et al.

Ingår i Molecular & Cellular Proteomics, 2023

• DOI för Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics
• Ladda ner fulltext (pdf) av Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics

A dominant negative splice variant of the heparan sulfate biosynthesis enzyme NDST1 reduces heparan sulfate sulfation

Missaghian, Parisa; Dierker, Tabea; Khosrowabadi, Elham; Axling, Fredrik et al.

Ingår i Glycobiology, s. 518-528, 2022

• DOI för A dominant negative splice variant of the heparan sulfate biosynthesis enzyme NDST1 reduces heparan sulfate sulfation
• Ladda ner fulltext (pdf) av A dominant negative splice variant of the heparan sulfate biosynthesis enzyme NDST1 reduces heparan sulfate sulfation

Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development

Habicher, Judith; Varshney, Gaurav K.; Waldmann, Laura; Snitting, Daniel et al.

Ingår i PLOS Genetics, 2022

• DOI för Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development
• Ladda ner fulltext (pdf) av Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development

Heparan Sulfate Biosynthesis in Zebrafish

Gorniok, Beata Filipek; Habicher, Judith; Ledin, Johan; Kjellén, Lena

Ingår i Journal of Histochemistry and Cytochemistry, s. 49-60, 2021

• DOI för Heparan Sulfate Biosynthesis in Zebrafish

Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate

Bachvarova, Velina; Dierker, Tabea; Esko, Jeffrey; Hoffmann, Daniel et al.

Ingår i Matrix Biology, s. 43-59, 2020

• DOI för Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate
• Ladda ner fulltext (pdf) av Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate

Establishment and characterization of Drosophila cell lines mutant for heparan sulfate modifying enzymes

Nakato, Eriko; Liu, Xin; Eriksson, Inger; Yamamoto, Maki et al.

Ingår i Glycobiology, s. 479-489, 2019

• DOI för Establishment and characterization of Drosophila cell lines mutant for heparan sulfate modifying enzymes

Expanding the chondroitin glycoproteome of Caenorhabditis elegans

Noborn, Fredrik; Toledo, Alejandro Gomez; Nasir, Waqas; Nilsson, Jonas et al.

Ingår i Journal of Biological Chemistry, s. 379-389, 2018

• DOI för Expanding the chondroitin glycoproteome of Caenorhabditis elegans

Mitogen-Activated Protein Kinase Signaling Regulates Proteoglycan Composition of Mast Cell Secretory Granules

Frisk, Jun Mei Hu; Kjellén, Lena; Melo, Fabio R.; Öhrvik, Helena et al.

Ingår i Frontiers in Immunology, 2018

• DOI för Mitogen-Activated Protein Kinase Signaling Regulates Proteoglycan Composition of Mast Cell Secretory Granules
• Ladda ner fulltext (pdf) av Mitogen-Activated Protein Kinase Signaling Regulates Proteoglycan Composition of Mast Cell Secretory Granules

Specificity of glycosaminoglycan-protein interactions

Kjellén, Lena; Lindahl, Ulf

Ingår i Current opinion in structural biology, s. 101-108, 2018

• DOI för Specificity of glycosaminoglycan-protein interactions

Copper Regulates Maturation and Expression of an MITF: Tryptase Axis in Mast Cells

Hu Frisk, Jun Mei; Kjellén, Lena; Kaler, Stephen G; Pejler, Gunnar et al.

Ingår i Journal of Immunology, s. 4132-4141, 2017

• DOI för Copper Regulates Maturation and Expression of an MITF: Tryptase Axis in Mast Cells

Heparanase confers a growth advantage to differentiating murine embryonic stem cells, and enhances oligodendrocyte formation.

Xiong, Anqi; Kundu, Soumi; Forsberg, Maud; Xiong, Yuyuan et al.

Ingår i Matrix Biology, s. 92-104, 2017

• DOI för Heparanase confers a growth advantage to differentiating murine embryonic stem cells, and enhances oligodendrocyte formation.

Identification of novel chondroitin sulfate sulfotransferases and proteoglycan core proteins in the nematode C. elegans

Dierker, Tabea; Noborn, F.; Hinas, Andrea; Kjellén, Lena

Ingår i International journal of experimental pathology (Print), 2017

Separation and Purification of Glycosaminoglycans (GAGs) from Caenorhabditis elegans

Dierker, Tabea; Kjellén, Lena

Ingår i Bio-protocol, 2017

• DOI för Separation and Purification of Glycosaminoglycans (GAGs) from Caenorhabditis elegans

Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones

Dierker, Tabea; Bachvarova, Velina; Krause, Yvonne; Li, Jin-Ping et al.

Ingår i Matrix Biology, s. 82-92, 2016

• DOI för Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones

Metastasis Stimulation by Hypoxia and Acidosis-Induced Extracellular Lipid Uptake Is Mediated by Proteoglycan-Dependent Endocytosis

Menard, Julien A.; Christianson, Helena C.; Kucharzewska, Paulina; Bourseau-Guilmain, Erika et al.

Ingår i Cancer Research, s. 4828-4840, 2016

• DOI för Metastasis Stimulation by Hypoxia and Acidosis-Induced Extracellular Lipid Uptake Is Mediated by Proteoglycan-Dependent Endocytosis

NDST2 (N-Deacetylase/N-Sulfotransferase-2) Enzyme Regulates Heparan Sulfate Chain Length

Deligny, Audrey; Dierker, Tabea; Dagälv, Anders; Lundequist, Anders et al.

Ingår i Journal of Biological Chemistry, s. 18600-18607, 2016

• DOI för NDST2 (N-Deacetylase/N-Sulfotransferase-2) Enzyme Regulates Heparan Sulfate Chain Length

Nematodes join the family of chondroitin sulfate-synthesizing organisms: Identification of an active chondroitin sulfotransferase in Caenorhabditis elegans

Dierker, Tabea; Shao, Chun; Haitina, Tatjana; Zaia, Joseph et al.

Ingår i Scientific Reports, 2016

• DOI för Nematodes join the family of chondroitin sulfate-synthesizing organisms: Identification of an active chondroitin sulfotransferase in Caenorhabditis elegans
• Ladda ner fulltext (pdf) av Nematodes join the family of chondroitin sulfate-synthesizing organisms: Identification of an active chondroitin sulfotransferase in Caenorhabditis elegans

Serglycin proteoglycans limit enteropathy in Trichinella spiralis-infected mice

Roy, Ananya; Sawesi, Osama; Pettersson, Ulrika A.; Dagälv, Anders et al.

Ingår i BMC Immunology, 2016

• DOI för Serglycin proteoglycans limit enteropathy in Trichinella spiralis-infected mice
• Ladda ner fulltext (pdf) av Serglycin proteoglycans limit enteropathy in Trichinella spiralis-infected mice

Versican accumulates in vascular lesions in pulmonary arterial hypertension

Chang, Ya-Ting; Chan, Christina K.; Eriksson, Inger; Johnson, Pamela Y. et al.

Ingår i PULMONARY CIRCULATION, s. 347-359, 2016

• DOI för Versican accumulates in vascular lesions in pulmonary arterial hypertension

Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans

Öhrvik, Helena; Logeman, Brandon; Noguchi, Glyn; Eriksson, Inger et al.

Ingår i Journal of Immunology, s. 3654-3664, 2015

• DOI för Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans
• Ladda ner fulltext (pdf) av Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans

Identification of Chondroitin Sulfate Linkage Region Glycopeptides Reveals Prohormones as a Novel Class of Proteoglycans

Noborn, Fredrik; Toledo, Alejandro Gomez; Sihlbom, Carina; Lengqvist, Johan et al.

Ingår i Molecular & Cellular Proteomics, s. 41-49, 2015

• DOI för Identification of Chondroitin Sulfate Linkage Region Glycopeptides Reveals Prohormones as a Novel Class of Proteoglycans

Profiling sulfation/epimerization pattern of full-length heparan sulfate by NMR following cell culture C-13-glucose metabolic labeling

Pegeot, Mathieu; Sadir, Rabia; Eriksson, Inger; Kjellén, Lena et al.

Ingår i Glycobiology, s. 151-156, 2015

• DOI för Profiling sulfation/epimerization pattern of full-length heparan sulfate by NMR following cell culture C-13-glucose metabolic labeling

The Ndst Gene Family in Zebrafish: Role of Ndst1b in Pharyngeal Arch Formation

Filipek-Gorniok, Beata; Carlsson, Pernilla; Haitina, Tatjana; Habicher, Judith et al.

Ingår i PLOS ONE, 2015

• DOI för The Ndst Gene Family in Zebrafish: Role of Ndst1b in Pharyngeal Arch Formation
• Ladda ner fulltext (pdf) av The Ndst Gene Family in Zebrafish: Role of Ndst1b in Pharyngeal Arch Formation

Mast Cell Chymase Degrades the Alarmins Heat Shock Protein 70, Biglycan, HMGB1, and Interleukin-33 (IL-33) and Limits Danger-induced Inflammation

Roy, Ananya; Ganesh, Goutham; Sippola, Helena; Bolin, Sara et al.

Ingår i Journal of Biological Chemistry, s. 237-250, 2014

• DOI för Mast Cell Chymase Degrades the Alarmins Heat Shock Protein 70, Biglycan, HMGB1, and Interleukin-33 (IL-33) and Limits Danger-induced Inflammation

Dimerized Glycosaminoglycan Chains Increase FGF Signaling during Zebrafish Development

Nguyen, Thao K. N.; Tran, Vy M.; Sorna, Venkataswamy; Eriksson, Inger et al.

Ingår i ACS Chemical Biology, s. 939-948, 2013

• DOI för Dimerized Glycosaminoglycan Chains Increase FGF Signaling during Zebrafish Development

Distorted Secretory Granule Composition in Mast Cells with Multiple Protease Deficiency

Grujic, Mirjana; Calounova, Gabriela; Eriksson, Inger; Feyerabend, Thorsten et al.

Ingår i Journal of Immunology, s. 3931-3938, 2013

• DOI för Distorted Secretory Granule Composition in Mast Cells with Multiple Protease Deficiency

Expression of chondroitin/dermatan sulfate glycosyltransferases during early zebrafish development

Filipek-Gorniok, Beata; Holmborn, Katarina; Haitina, Tatjana; Habicher, Judith et al.

Ingår i Developmental Dynamics, s. 964-975, 2013

• DOI för Expression of chondroitin/dermatan sulfate glycosyltransferases during early zebrafish development

MicroRNA-24 Suppression of N-Deacetylase/N-Sulfotransferase-1 (NDST1) Reduces Endothelial Cell Responsiveness to Vascular Endothelial Growth Factor A (VEGFA)

Kasza, Zsolt; Fredlund Fuchs, Peder; Tamm, Christoffer; Eriksson, Anna S. et al.

Ingår i Journal of Biological Chemistry, s. 25956-25963, 2013

• DOI för MicroRNA-24 Suppression of N-Deacetylase/N-Sulfotransferase-1 (NDST1) Reduces Endothelial Cell Responsiveness to Vascular Endothelial Growth Factor A (VEGFA)

Pathophysiology of heparan sulphate: many diseases, few drugs

Lindahl, Ulf; Kjellén, Lena

Ingår i Journal of Internal Medicine, s. 555-571, 2013

• DOI för Pathophysiology of heparan sulphate: many diseases, few drugs
• Ladda ner fulltext (pdf) av Pathophysiology of heparan sulphate: many diseases, few drugs

Functional Overlap Between Chondroitin and Heparan Sulfate Proteoglycans During VEGF-Induced Sprouting Angiogenesis

Le Jan, Sébastien; Hayashi, Makoto; Kasza, Zsolt; Eriksson, Inger et al.

Ingår i Arteriosclerosis, Thrombosis and Vascular Biology, s. 1255-1263, 2012

• DOI för Functional Overlap Between Chondroitin and Heparan Sulfate Proteoglycans During VEGF-Induced Sprouting Angiogenesis

Glycobiology: Enzyme deficiencies deciphered

Kjellén, Lena

Ingår i Nature chemical biology, s. 137-138, 2012

• DOI för Glycobiology: Enzyme deficiencies deciphered

Heparan Sulfate Biosynthesis Enzymes in Embryonic Stem Cell Biology

Tamm, Christoffer; Kjellén, Lena; Li, Jin-Ping

Ingår i Journal of Histochemistry and Cytochemistry, s. 943-949, 2012

• DOI för Heparan Sulfate Biosynthesis Enzymes in Embryonic Stem Cell Biology

Heparan Sulfate Biosynthesis: Regulation and Variability

Kreuger, Johan; Kjellén, Lena

Ingår i Journal of Histochemistry and Cytochemistry, s. 898-907, 2012

• DOI för Heparan Sulfate Biosynthesis: Regulation and Variability

Heparin biosynthesis

Carlsson, Pernilla; Kjellén, Lena

Ingår i Handbook of experimental pharmacology, s. 23-41, 2012

• DOI för Heparin biosynthesis

Undersulfation of Heparan Sulfate Restricts Differentiation Potential of Mouse Embryonic Stem Cells

Forsberg, Maud; Holmborn, Katarina; Kundu, Soumi; Dagälv, Anders et al.

Ingår i Journal of Biological Chemistry, s. 10853-10862, 2012

• DOI för Undersulfation of Heparan Sulfate Restricts Differentiation Potential of Mouse Embryonic Stem Cells

Lowered Expression of Heparan Sulfate/Heparin Biosynthesis Enzyme N-Deacetylase/N-Sulfotransferase 1 Results in Increased Sulfation of Mast Cell Heparin

Dagälv, Anders; Holmborn, Katarina; Kjellén, Lena; Åbrink, Magnus

Ingår i Journal of Biological Chemistry, s. 44433-44440, 2011

• DOI för Lowered Expression of Heparan Sulfate/Heparin Biosynthesis Enzyme N-Deacetylase/N-Sulfotransferase 1 Results in Increased Sulfation of Mast Cell Heparin

Mucopolysaccharidosis Type I, Unique Structure of Accumulated Heparan Sulfate and Increased N-Sulfotransferase Activity in Mice Lacking alpha-L-iduronidase

Holley, Rebecca J.; Deligny, Audrey; Wei, Wei; Watson, H. Angharad et al.

Ingår i Journal of Biological Chemistry, s. 37515-37524, 2011

• DOI för Mucopolysaccharidosis Type I, Unique Structure of Accumulated Heparan Sulfate and Increased N-Sulfotransferase Activity in Mice Lacking alpha-L-iduronidase

Mesomelia-Synostoses Syndrome Results from Deletion of SULF1 and SLCO5A1 Genes at 8q13

Isidor, Bertrand; Pichon, Olivier; Redon, Richard; Day-Salvatore, Debra et al.

Ingår i American Journal of Human Genetics, s. 95-100, 2010

• DOI för Mesomelia-Synostoses Syndrome Results from Deletion of SULF1 and SLCO5A1 Genes at 8q13

Mice deficient in heparan sulfate N-deacetylase/N-sulfotransferase 1.

Ringvall, Maria; Kjellén, Lena

Ingår i Progress in molecular biology and translational science, s. 35-58, 2010

• DOI för Mice deficient in heparan sulfate N-deacetylase/N-sulfotransferase 1.

Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation

Presto, Jenny; Thuveson, Maria; Carlsson, Pernilla; Busse, Marta et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 4751-4756, 2008

• DOI för Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation

Heparin/heparan sulfate biosynthesis: Processive formation of N-sulfated domains

Carlsson, Pernilla; Presto, Jenny; Spillmann, Dorothe; Lindahl, Ulf et al.

Ingår i Journal of Biological Chemistry, s. 20008-20014, 2008

• DOI för Heparin/heparan sulfate biosynthesis: Processive formation of N-sulfated domains

Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization

Kawamura, Harukiyo; Li, Xiujuan; Goishi, Katsutoshi; van Meeteren, Laurens A et al.

Ingår i Blood, s. 3638-49, 2008

• DOI för Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization

Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation

Busse, Marta; Feta, Almir; Presto, Jenny; Wilén, Maria et al.

Ingår i Journal of Biological Chemistry, s. 32802-32810, 2007

• DOI för Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation

Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development

Abramsson, Alexandra; Kurup, Sindhulakshmi; Yamada, Shuhei; Lindblom, Per et al.

Ingår i Genes & Development, s. 316-331, 2007

• DOI för Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development

Enzymatically active N-deacetylase/N-sulfotransferase-2 is present in liver but does not contribute to heparan sulfate N-sulfation

Ledin, Johan; Ringvall, Maria; Thuveson, Maria; Eriksson, Inger et al.

Ingår i Journal of Biological Chemistry, s. 35727-35734, 2006

• DOI för Enzymatically active N-deacetylase/N-sulfotransferase-2 is present in liver but does not contribute to heparan sulfate N-sulfation

Heparan sulfate in trans potentiates VEGFR-mediated angiogenesis

Jakobsson, Lars; Kreuger, Johan; Holmborn, Katarina; Lundin, Lars et al.

Ingår i Developmental Cell, s. 625-634, 2006