Publications

On the road to blood biomarkers in myasthenia gravis (MG): Beyond clinical scales

Bhandage, Amol; Huang, Yu-Fang; Punga, Tanel; Rostedt Punga, Anna

Part of Journal of Neuromuscular Diseases, p. 493-506, 2026

• DOI for On the road to blood biomarkers in myasthenia gravis (MG): Beyond clinical scales
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The C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration

Punga, Tanel; Larsson, Mårten; Mujica, Endrina; Melo, Fabio R. et al.

Part of Scientific Reports, 2026

• DOI for The C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration
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Anti-gene oligonucleotides targeting Friedreich's ataxia expanded GAA•TTC repeats increase Frataxin expression

Mozafari, Negin; Milagres, Salome; Umek, Tea; Rocha, Cristina S. J. et al.

Part of Molecular Therapy Nucleic Acids, 2025

• DOI for Anti-gene oligonucleotides targeting Friedreich's ataxia expanded GAA•TTC repeats increase Frataxin expression
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Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation

Zhao, Liuqun; Punga, Tanel; Sanyal, Suparna

Part of eLIFE, 2025

• DOI for Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation
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Complex regulation of mitochondrial signaling by human adenovirus minor capsid protein VI

Schubert, Erik; Mun, Kwangchol; Larsson, Mårten; Panagiotou, Styliani et al.

Part of Journal of Virology, 2024

• DOI for Complex regulation of mitochondrial signaling by human adenovirus minor capsid protein VI

Serum protein biomarker profile distinguishes acetylcholine receptor antibody seropositive myasthenia gravis patients from healthy controls.

Bhandage, Amol; Kenina, Viktorija; Huang, Yu-Fang; Roddate, Marija et al.

Part of iScience, p. 110564, 2024

• DOI for Serum protein biomarker profile distinguishes acetylcholine receptor antibody seropositive myasthenia gravis patients from healthy controls.
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Fragile X-Related Protein FXR1 Controls Human Adenovirus Capsid mRNA Metabolism

Hajikhezri, Zamaneh; Kaira, Yanina; Schubert, Erik; Darweesh, Mahmoud et al.

Part of Journal of Virology, 2023

• DOI for Fragile X-Related Protein FXR1 Controls Human Adenovirus Capsid mRNA Metabolism

The RNA-binding protein ZC3H11A interacts with the nuclear poly(A)-binding protein PABPN1 and alters polyadenylation of viral transcripts

Kases, Katharina; Schubert, Erik; Hajikhezri, Zamaneh; Larsson, Mårten et al.

Part of Journal of Biological Chemistry, 2023

• DOI for The RNA-binding protein ZC3H11A interacts with the nuclear poly(A)-binding protein PABPN1 and alters polyadenylation of viral transcripts
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Activation of the Ca²⁺/NFAT pathway by assembly of hepatitis C virus core protein into nucleocapsid-like particles

Devi, Priya; Punga, Tanel; Bergqvist, Anders

Part of Viruses, 2022

• DOI for Activation of the Ca²⁺/NFAT pathway by assembly of hepatitis C virus core protein into nucleocapsid-like particles
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Next-Generation Sequencing Analysis of CpG Methylation of a Tumor Suppressor Gene SHP-1 Promoter in Stable Cell Lines and HCV-Positive Patients

Devi, Priya; Engdahl, Katarina; Punga, Tanel; Bergqvist, Anders

Part of Viruses, 2022

• DOI for Next-Generation Sequencing Analysis of CpG Methylation of a Tumor Suppressor Gene SHP-1 Promoter in Stable Cell Lines and HCV-Positive Patients
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Structural Insights into Human Adenovirus Type 4 Virus-Associated RNA I

Bergquist, Helen; Inturi, Raviteja; Zain, Rula; Punga, Tanel

Part of International Journal of Molecular Sciences, 2022

• DOI for Structural Insights into Human Adenovirus Type 4 Virus-Associated RNA I
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ZC3H11A loss of function enhances NF-κB signaling through defective IκBα protein expression

Darweesh, Mahmoud; Younis, Shady; Hajikhezri, Zamaneh; Ali, Arwa et al.

Part of Frontiers in Immunology, 2022

• DOI for ZC3H11A loss of function enhances NF-κB signaling through defective IκBα protein expression
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Hepatitis C Virus Core Protein Down-Regulates Expression of Src-Homology 2 Domain Containing Protein Tyrosine Phosphatase by Modulating Promoter DNA Methylation

Devi, Priya; Ota, Seisuke; Punga, Tanel; Bergqvist, Anders

Part of Viruses, p. 2514-2514, 2021

• DOI for Hepatitis C Virus Core Protein Down-Regulates Expression of Src-Homology 2 Domain Containing Protein Tyrosine Phosphatase by Modulating Promoter DNA Methylation
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Adenovirus in the omics era - a multi-pronged strategy.

Zhao, Hongxing; Punga, Tanel; Pettersson, Ulf

Part of FEBS Letters, p. 1879-1890, 2020

• DOI for Adenovirus in the omics era - a multi-pronged strategy.

Circulating miRNAs as Potential Biomarkers in Myasthenia Gravis: Tools for Personalized Medicine

Sabre, Liis; Punga, Tanel; Rostedt Punga, Anna

Part of Frontiers in Immunology, 2020

• DOI for Circulating miRNAs as Potential Biomarkers in Myasthenia Gravis: Tools for Personalized Medicine
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Estrogen Receptor, Inflammatory, and FOXO Transcription Factors Regulate Expression of Myasthenia Gravis-Associated Circulating microRNAs

Fiorillo, Alyson A.; Heier, Christopher R.; Huang, Yu-Fang; Tully, Christopher B. et al.

Part of Frontiers in Immunology, 2020

• DOI for Estrogen Receptor, Inflammatory, and FOXO Transcription Factors Regulate Expression of Myasthenia Gravis-Associated Circulating microRNAs
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miR-1933-3p is upregulated in skeletal muscles of MuSK+ EAMG mice and affects Impa1 and Mrpl27

Bogatikov, Evgenii; Lindblad, Ida; Punga, Tanel; Rostedt Punga, Anna

Part of Neuroscience research, p. 46-52, 2020

• DOI for miR-1933-3p is upregulated in skeletal muscles of MuSK+ EAMG mice and affects Impa1 and Mrpl27

Role of CCCH-Type Zinc Finger Proteins in Human Adenovirus Infections

Hajikhezri, Zamaneh; Darweesh, Mahmoud; Akusjärvi, Göran; Punga, Tanel

Part of Viruses, 2020

• DOI for Role of CCCH-Type Zinc Finger Proteins in Human Adenovirus Infections
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Synthesis, Structure, and Function of Human Adenovirus Small Non-Coding RNAs

Punga, Tanel; Darweesh, Mahmoud; Akusjärvi, Göran

Part of Viruses, 2020

• DOI for Synthesis, Structure, and Function of Human Adenovirus Small Non-Coding RNAs
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Cellular Zinc Finger Protein 622 Hinders Human Adenovirus Lytic Growth and Limits Binding of the Viral pVII Protein to Virus DNA

Mun, Kwangchol; Punga, Tanel

Part of Journal of Virology, 2019

• DOI for Cellular Zinc Finger Protein 622 Hinders Human Adenovirus Lytic Growth and Limits Binding of the Viral pVII Protein to Virus DNA

Circulating microRNAs as potential biomarkers in myasthenia gravis patients.

Rostedt Punga, Anna; Punga, Tanel

Part of Annals of the New York Academy of Sciences, p. 33-40, 2018

• DOI for Circulating microRNAs as potential biomarkers in myasthenia gravis patients.

Human Adenovirus Infection Causes Cellular E3 Ubiquitin Ligase MKRN1 Degradation Involving the Viral Core Protein pVII.

Inturi, Raviteja; Mun, Kwangchol; Singethan, Katrin; Schreiner, Sabrina et al.

Part of Journal of Virology, 2018

• DOI for Human Adenovirus Infection Causes Cellular E3 Ubiquitin Ligase MKRN1 Degradation Involving the Viral Core Protein pVII.

In Situ Detection of Adenovirus DNA and mRNA in Individual Cells.

Punga, Tanel; Ciftci, Sibel; Nilsson, Mats; Krzywkowski, Tomasz

Part of Current protocols in microbiology, 2018

• DOI for In Situ Detection of Adenovirus DNA and mRNA in Individual Cells.

Thymectomy lowers the myasthenia gravis biomarker miR-150-5p

Molin, Carl Johan; Sabre, Liis; Weis, Cleo-Aron; Punga, Tanel et al.

Part of Neurology, 2018

• DOI for Thymectomy lowers the myasthenia gravis biomarker miR-150-5p
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Expression profile of Epstein-Barr virus and human adenovirus small RNAs in tonsillar B and T lymphocytes

Assadian, Farzaneh; Kamel, Wael; Laurell, Göran; Svensson, Catharina et al.

Part of PLOS ONE, 2017

• DOI for Expression profile of Epstein-Barr virus and human adenovirus small RNAs in tonsillar B and T lymphocytes
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Simultaneous Single-Cell In Situ Analysis of Human Adenovirus Type 5 DNA and mRNA Expression Patterns in Lytic and Persistent Infection

Krzywkowski, Tomasz; Ciftci, Sibel; Assadian, Farzaneh; Nilsson, Mats et al.

Part of Journal of Virology, 2017

• DOI for Simultaneous Single-Cell In Situ Analysis of Human Adenovirus Type 5 DNA and mRNA Expression Patterns in Lytic and Persistent Infection

The adenovirus L4-22K protein regulates transcription and RNA splicing via a sequence-specific single-stranded RNA binding

Lan, Susan; Kamel, Wael; Punga, Tanel; Akusjärvi, Göran

Part of Nucleic Acids Research, p. 1731-1742, 2017

• DOI for The adenovirus L4-22K protein regulates transcription and RNA splicing via a sequence-specific single-stranded RNA binding
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Clamping of RNA with PNA enables targeting of microRNA

Ghidini, Alice; Bergquist, Helen; Murtola, Merita; Punga, Tanel et al.

Part of Organic and biomolecular chemistry, p. 5210-5213, 2016

• DOI for Clamping of RNA with PNA enables targeting of microRNA

Disease specific enrichment of circulating let-7 family microRNA in MuSK+ myasthenia gravis.

Punga, Tanel; Bartoccioni, Emanuela; Lewandowska, Marta; Damato, Valentina et al.

Part of Journal of Neuroimmunology, p. 21-26, 2016

• DOI for Disease specific enrichment of circulating let-7 family microRNA in MuSK+ myasthenia gravis.
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Distribution and Molecular Characterization of Human Adenovirus and Epstein-Barr Virus Infections in Tonsillar Lymphocytes Isolated from Patients Diagnosed with Tonsillar Diseases

Assadian, Farzaneh; Sandström, Karl; Bondeson, Kåre; Laurell, Göran et al.

Part of PLOS ONE, 2016

• DOI for Distribution and Molecular Characterization of Human Adenovirus and Epstein-Barr Virus Infections in Tonsillar Lymphocytes Isolated from Patients Diagnosed with Tonsillar Diseases
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A suppressive effect of Sp1 recruitment to the first leader 5' splice site region on L4-22K-mediated activation of the adenovirus major late promoter

Lan, Susan; Östberg, Sara; Punga, Tanel; Akusjärvi, Göran

Part of Virus Research, p. 133-140, 2015

• DOI for A suppressive effect of Sp1 recruitment to the first leader 5' splice site region on L4-22K-mediated activation of the adenovirus major late promoter

Complementation of the human adenovirus type 5 VA RNAI defect by the Vaccinia virus E3L protein and serotype-specific VA RNAIs

Inturi, Raviteja; Kamel, Wael; Akusjärvi, Göran; Punga, Tanel

Part of Virology, p. 25-35, 2015

• DOI for Complementation of the human adenovirus type 5 VA RNAI defect by the Vaccinia virus E3L protein and serotype-specific VA RNAIs

Disease specific signature of circulating miR-150-5p and miR-21-5p in myasthenia gravis patients

Punga, Anna Rostedt; Andersson, Mats; Alimohammadi, Mohammad; Punga, Tanel

Part of Journal of the Neurological Sciences, p. 90-96, 2015

• DOI for Disease specific signature of circulating miR-150-5p and miR-21-5p in myasthenia gravis patients
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Efficient Isolation Protocol for B and T Lymphocytes from Human Palatine Tonsils

Assadian, Farzaneh; Sandström, Karl; Laurell, Göran; Svensson, Catharina et al.

Part of Journal of Visualized Experiments, 2015

• DOI for Efficient Isolation Protocol for B and T Lymphocytes from Human Palatine Tonsils

Genome-Engineering Tools to Establish Accurate Reporter Cell Lines That Enable Identification of Therapeutic Strategies to Treat Friedreich's Ataxia

Villaseñor, Rodrigo; Miraglia, Loren; Romero, Angelica; Tu, Buu et al.

Part of Journal of Biomolecular Screening, p. 760-767, 2015

• DOI for Genome-Engineering Tools to Establish Accurate Reporter Cell Lines That Enable Identification of Therapeutic Strategies to Treat Friedreich's Ataxia

Opposite expression of CYP51A1 and its natural antisense transcript AluCYP51A1 in adenovirus type 37 infected retinal pigmented epithelial cells

Pickl, Julia Maria Anna; Kamel, Wael; Ciftci, Sibel; Punga, Tanel et al.

Part of FEBS Letters, p. 1383-1388, 2015

• DOI for Opposite expression of CYP51A1 and its natural antisense transcript AluCYP51A1 in adenovirus type 37 infected retinal pigmented epithelial cells

A splice variant of the human phosphohistidine phosphatase 1 (PHPT1) is degraded by the proteasome

Inturi, Raviteja; Wäneskog, Marcus; Vlachakis, Dimitrios; Ali, Yeasmeen et al.

Part of International Journal of Biochemistry and Cell Biology, p. 69-75, 2014

• DOI for A splice variant of the human phosphohistidine phosphatase 1 (PHPT1) is degraded by the proteasome
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Circulating miRNAs in myasthenia gravis: miR-150-5p as a new potential biomarker

Punga, Tanel; Le Panse, Rozen; Andersson, Mats; Truffault, Frédérique et al.

Part of Annals of clinical and translational neurology, p. 49-58, 2014

• DOI for Circulating miRNAs in myasthenia gravis: miR-150-5p as a new potential biomarker

Small RNA Sequence Analysis of Adenovirus VA RNA-Derived MiRNAs Reveals an Unexpected Serotype-Specific Difference in Structure and Abundance

Kamel, Wael; Segerman, Bo; Punga, Tanel; Akusjärvi, Göran

Part of PLOS ONE, 2014

• DOI for Small RNA Sequence Analysis of Adenovirus VA RNA-Derived MiRNAs Reveals an Unexpected Serotype-Specific Difference in Structure and Abundance
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Adenovirus Precursor pVII Protein Stability Is Regulated By Its Propeptide Sequence

Inturi, Raviteja; Thaduri, Srinivas; Punga, Tanel

Part of PLOS ONE, 2013

• DOI for Adenovirus Precursor pVII Protein Stability Is Regulated By Its Propeptide Sequence
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Muscle-specific regulation of the mTOR signaling pathway in MuSK antibody seropositive (MuSK plus ) experimental autoimmune Myasthenia gravis (EAMG)

Chauhan, Mayank; Punga, Tanel; Punga, Anna Rostedt

Part of Neuroscience research, p. 102-109, 2013

• DOI for Muscle-specific regulation of the mTOR signaling pathway in MuSK antibody seropositive (MuSK plus ) experimental autoimmune Myasthenia gravis (EAMG)

Old and new functions for the adenovirus virus-associated RNAs

Punga, Tanel; Kamel, Wael; Akusjarvi, Göran

Part of Future Virology, p. 343-356, 2013

• DOI for Old and new functions for the adenovirus virus-associated RNAs

The adenovirus VA RNA-derived miRNAs are not essential for lytic virus growth in tissue culture cells

Kamel, Wael; Segerman, Bo; Oberg, Daniel; Punga, Tanel et al.

Part of Nucleic Acids Research, p. 4802-4812, 2013

• DOI for The adenovirus VA RNA-derived miRNAs are not essential for lytic virus growth in tissue culture cells
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Two Cellular Protein Kinases, DNA-PK and PKA, Phosphorylate the Adenoviral L4-33K Protein and Have Opposite Effects on L1 Alternative RNA Splicing

Törmänen Persson, Heidi; Aksaas, Anne Kristin; Kvissel, Anne Katrine; Punga, Tanel et al.

Part of PLOS ONE, 2012

• DOI for Two Cellular Protein Kinases, DNA-PK and PKA, Phosphorylate the Adenoviral L4-33K Protein and Have Opposite Effects on L1 Alternative RNA Splicing
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Dicer associates with chromatin to repress genome activity in Schizosaccharomyces pombe

Woolcock, Katrina J; Gaidatzis, Dimos; Punga, Tanel; Bühler, Marc

Part of Nature Structural & Molecular Biology, p. 94-99, 2011

• DOI for Dicer associates with chromatin to repress genome activity in Schizosaccharomyces pombe

Long intronic GAA repeats causing Friedreich ataxia impede transcription elongation

Punga, Tanel; Bühler, Marc

Part of EMBO Molecular Medicine, p. 120-129, 2010

• DOI for Long intronic GAA repeats causing Friedreich ataxia impede transcription elongation

Novel genes in cell cycle control and lipid metabolism with dynamically regulated binding sites for sterol regulatory element-binding protein 1 and RNA polymerase II in HepG2 cells detected by chromatin immunoprecipitation with microarray detection

Motallebipour, Mehdi; Enroth, Stefan; Punga, Tanel; Ameur, Adam et al.

Part of The FEBS Journal, p. 1878-1890, 2009

• DOI for Novel genes in cell cycle control and lipid metabolism with dynamically regulated binding sites for sterol regulatory element-binding protein 1 and RNA polymerase II in HepG2 cells detected by chromatin immunoprecipitation with microarray detection

Hyperphosphorylation regulates the activity of SREBP1 during mitosis

Bengoechea-Alonso, Maria T; Punga, Tanel; Ericsson, Johan

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 11681-11686, 2005

• DOI for Hyperphosphorylation regulates the activity of SREBP1 during mitosis

YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress

Grönroos, Eva; Terentiev, Alexei A; Punga, Tanel; Ericsson, Johan

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 12165-12170, 2004

• DOI for YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress

Adenovirus 2 E1B-55K protein relieves p53-mediated transcriptional repression of the survivin and MAP4 promoters

Punga, Tanel; Akusjärvi, Göran

Part of FEBS Letters, p. 214-218, 2003

• DOI for Adenovirus 2 E1B-55K protein relieves p53-mediated transcriptional repression of the survivin and MAP4 promoters