Publications

An international perspective on the future of systemic sclerosis research

Abraham, David J.; Black, Carol M.; Denton, Christopher P.; Distler, Jörg H. W. et al.

Part of Nature Reviews Rheumatology, p. 174-187, 2025

• DOI for An international perspective on the future of systemic sclerosis research

Inhibition of integrin alpha(V)beta(6) changes fibril thickness of stromal collagen in experimental carcinomas

Olsson, P. Olof; Gustafsson, Renata; Salnikov, Alexei, V; Göthe, Maria et al.

Part of Cell Communication and Signaling, 2018

• DOI for Inhibition of integrin alpha(V)beta(6) changes fibril thickness of stromal collagen in experimental carcinomas
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Integrin α_Vβ₃ can substitute for collagen‐binding β₁‐integrins in vivo to maintain a homeostatic interstitial fluid pressure

Liden, Åsa; Karlsen, Tine Veronika; Guss, Bengt; Reed, Rolf K. et al.

Part of Experimental Physiology, p. 629-634, 2018

• DOI for Integrin α_Vβ₃ can substitute for collagen‐binding β₁‐integrins in vivo to maintain a homeostatic interstitial fluid pressure
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The endoplasmic reticulum-resident collagen chaperone Hsp47 interacts with and promotes the secretion of decorin, fibromodulin, and lumican

Ishikawa, Yoshihiro; Rubin, Kristofer; Bächinger, Hans Peter; Kalamajski, Sebastian

Part of Journal of Biological Chemistry, p. 13707-13716, 2018

• DOI for The endoplasmic reticulum-resident collagen chaperone Hsp47 interacts with and promotes the secretion of decorin, fibromodulin, and lumican

Fibromodulin deficiency reduces collagen structural network but not glycosaminoglycan content in a syngeneic model of colon carcinoma.

Olsson, P Olof; Kalamajski, Sebastian; Maccarana, Marco; Oldberg, Åke et al.

Part of PLOS ONE, 2017

• DOI for Fibromodulin deficiency reduces collagen structural network but not glycosaminoglycan content in a syngeneic model of colon carcinoma.
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Imatinib increases oxygen delivery in extracellular matrix-rich but not in matrix-poor experimental carcinoma

Burmakin, Mikhail; van Wieringen, Tijs; Olsson, P. Olof; Stuhr, Linda et al.

Part of Journal of Translational Medicine, 2017

• DOI for Imatinib increases oxygen delivery in extracellular matrix-rich but not in matrix-poor experimental carcinoma
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PDGF-BB enhances collagen gel contraction through a PI3K-PLCγ-PKC-cofilin pathway

Reyhani, Vahid; Tsioumpekou, Maria; van Wieringen, Tijs; Rask, Lars et al.

Part of Scientific Reports, 2017

• DOI for PDGF-BB enhances collagen gel contraction through a PI3K-PLCγ-PKC-cofilin pathway
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Fibromodulin Interacts with Collagen Cross-linking Sites and Activates Lysyl Oxidase.

Kalamajski, Sebastian; Bihan, Dominique; Bonna, Arkadiusz; Rubin, Kristofer et al.

Part of Journal of Biological Chemistry, p. 7951-60, 2016

• DOI for Fibromodulin Interacts with Collagen Cross-linking Sites and Activates Lysyl Oxidase.

Normal oral keratinocytes and head and neck squamous carcinoma cells induce an innate response in fibroblasts

Hakelius, Malin; Reyhani, Vahid; Rubin, Kristofer; Gerdin, Bengt et al.

Part of Anticancer Research, p. 2131-2137, 2016

The Tyrosine Kinase Inhibitor Imatinib Augments Extracellular Fluid Exchange and Reduces Average Collagen Fibril Diameter in Experimental Carcinoma

Olsson, P. Olof; Gustafsson, Renata; in 't Zandt, Rene; Friman, Tomas et al.

Part of Molecular Cancer Therapeutics, p. 2455-2464, 2016

• DOI for The Tyrosine Kinase Inhibitor Imatinib Augments Extracellular Fluid Exchange and Reduces Average Collagen Fibril Diameter in Experimental Carcinoma

O-15-Water PET Study of the Effect of Imatinib, a Selective Platelet-Derived Growth Factor Receptor Inhibitor, Versus Anakinra, an IL-1R Antagonist, on Water-Perfusable Tissue Fraction in Colorectal Cancer Metastases

Lubberink, Mark; Golla, Sanjeep S. V.; Jonasson, My; Rubin, Kristofer et al.

Part of Journal of Nuclear Medicine, p. 1144-1149, 2015

• DOI for O-15-Water PET Study of the Effect of Imatinib, a Selective Platelet-Derived Growth Factor Receptor Inhibitor, Versus Anakinra, an IL-1R Antagonist, on Water-Perfusable Tissue Fraction in Colorectal Cancer Metastases

Fibrin binds to collagen and provides a bridge for alpha V beta 3 integrin-dependent contraction of collagen gels

Reyhani, Vahid; Seddigh, Pegah; Guss, Bengt; Gustafsson, Renata et al.

Part of Biochemical Journal, p. 113-123, 2014

• DOI for Fibrin binds to collagen and provides a bridge for alpha V beta 3 integrin-dependent contraction of collagen gels

Increased C-telopeptide Cross-linking of Tendon Type I Collagen in Fibromodulin-deficient Mice

Kalamajski, Sebastian; Liu, Cuiping; Tillgren, Viveka; Rubin, Kristofer et al.

Part of Journal of Biological Chemistry, p. 18873-18879, 2014

• DOI for Increased C-telopeptide Cross-linking of Tendon Type I Collagen in Fibromodulin-deficient Mice

Keratinocytes and Head and Neck Squamous Cell Carcinoma Cells Regulate Urokinase-type Plasminogen Activator and Plasminogen Activator Inhibitor-1 in Fibroblasts

Hakelius, Malin; Koskela, Anita; Ivarsson, Mikael; Grenman, Reidar et al.

Part of Anticancer Research, p. 3113-3118, 2013

Mice Lacking NCF1 Exhibit Reduced Growth of Implanted Melanoma and Carcinoma Tumors

Kelkka, Tiina; Pizzolla, Angela; Laurila, Juha Petteri; Friman, Tomas et al.

Part of PLOS ONE, 2013

• DOI for Mice Lacking NCF1 Exhibit Reduced Growth of Implanted Melanoma and Carcinoma Tumors
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Increased Fibrosis and Interstitial Fluid Pressure in Two Different Types of Syngeneic Murine Carcinoma Grown in Integrin β3-Subunit Deficient Mice

Friman, Tomas; Gustafsson, Renata; Stuhr, Linda B.; Chidiac, Jean et al.

Part of PLOS ONE, 2012

• DOI for Increased Fibrosis and Interstitial Fluid Pressure in Two Different Types of Syngeneic Murine Carcinoma Grown in Integrin β3-Subunit Deficient Mice
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Interleukin-1-mediated effects of normal oral keratinocytes and head and neck squamous carcinoma cells on extracellular matrix related gene expression in fibroblasts

Hakelius, Malin; Koskela, Anita; Reyhani, Vahid; Ivarsson, Mikael et al.

Part of Oral Oncology, p. 1236-1241, 2012

• DOI for Interleukin-1-mediated effects of normal oral keratinocytes and head and neck squamous carcinoma cells on extracellular matrix related gene expression in fibroblasts

Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner

Xie, Liang; Duncan, Michael B.; Pahler, Jessica; Sugimoto, Hikaru et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 9939-9944, 2011

• DOI for Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner

Edema and fluid dynamics in connective tissue remodelling

Reed, Rolf K.; Lidén, Åsa; Rubin, Kristofer

Part of Journal of Molecular and Cellular Cardiology, p. 518-523, 2010

• DOI for Edema and fluid dynamics in connective tissue remodelling

The streptococcal collagen-binding protein CNE specifically interferes with {alpha}V{beta}3-mediated cellular interactions with triple helical collagen

van Wieringen, Tijs; Kalamajski, Sebastian; Lidén, Åsa; Bihan, Dominique et al.

Part of Journal of Biological Chemistry, p. 35803-35813, 2010

• DOI for The streptococcal collagen-binding protein CNE specifically interferes with {alpha}V{beta}3-mediated cellular interactions with triple helical collagen

Transcapillary exchange: role and importance of the interstitial fluid pressure and the extracellular matrix

Reed, Rolf K.; Rubin, Kristofer

Part of Cardiovascular Research, p. 211-217, 2010

• DOI for Transcapillary exchange: role and importance of the interstitial fluid pressure and the extracellular matrix

Type I interferon system activation and association with disease manifestations in systemic sclerosis

Eloranta, Maija-Leena; Franck-Larsson, Karin; Lövgren, Tanja; Kalamajski, Sebastian et al.

Part of Annals of the Rheumatic Diseases, p. 1396-1402, 2010

• DOI for Type I interferon system activation and association with disease manifestations in systemic sclerosis

Combined anti-angiogenic therapy targeting PDGF and VEGF receptors lowers the interstitial fluid pressure in a murine experimental carcinoma

Kłosowska-Wardega, Agnieszka; Hasumi, Yoko; Burmakin, Mikhail; Åhgren, Aive et al.

Part of PloS one, 2009

• DOI for Combined anti-angiogenic therapy targeting PDGF and VEGF receptors lowers the interstitial fluid pressure in a murine experimental carcinoma

Integrin α₁β₁ is Involved in the Differentiation into Myofibroblasts in Adult Reactive Tissues in vivo

Rodriguez, Alejandro; Karén, Jakob; Gardner, Humphrey; Gerdin, Bengt et al.

Part of Journal of Cellular and Molecular Medicine, p. 3449-3462, 2009

• DOI for Integrin α₁β₁ is Involved in the Differentiation into Myofibroblasts in Adult Reactive Tissues in vivo

Lowered albumin extravasation rate in heart but not in other organs in beta3-integrin-deficient mice

Svendsen, O S; Lidén, A; Rubin, Kristofer; Reed, R K

Part of Acta Physiologica, p. 305-311, 2009

• DOI for Lowered albumin extravasation rate in heart but not in other organs in beta3-integrin-deficient mice

Opposite effects of PDGF-BB and prostaglandin E(1) on cell-motility related processes are paralleled by modifications of distinct actin-binding proteins

van Wieringen, Tijs; Kimani, Stanley G.; Hultgard-Ekwall, Anna-Karin; Forsberg, Jens et al.

Part of Experimental Cell Research, p. 1745-1758, 2009

• DOI for Opposite effects of PDGF-BB and prostaglandin E(1) on cell-motility related processes are paralleled by modifications of distinct actin-binding proteins

A secreted collagen- and fibronectin-binding streptococcal protein modulates cell-mediated collagen gel contraction and interstitial fluid pressure

Lidén, Åsa; van Wieringen, Tijs; Lannergård, Jonas; Kassner, Anja et al.

Part of Journal of Biological Chemistry, p. 1234-1242, 2008

• DOI for A secreted collagen- and fibronectin-binding streptococcal protein modulates cell-mediated collagen gel contraction and interstitial fluid pressure

Integrin alphavbeta3 acts downstream of insulin in normalization of interstitial fluid pressure in sepsis and in cell-mediated collagen gel contraction

Svendsen, Oyvind Sverre; Lidén, Asa; Nedrebø, Torbjørn; Rubin, Kristofer et al.

Part of American Journal of Physiology. Heart and Circulatory Physiology, 2008

• DOI for Integrin alphavbeta3 acts downstream of insulin in normalization of interstitial fluid pressure in sepsis and in cell-mediated collagen gel contraction

Peritumoral TNF alpha administration influences tumour stroma structure and physiology independently of growth in DMBA-induced mammary tumours

Stuhr, Linda E. B.; Moen, Ingrid; Nedrebo, Torbjorn; Salnikov, Alexei V. et al.

Part of Scandinavian Journal of Clinical and Laboratory Investigation, p. 602-611, 2008

• DOI for Peritumoral TNF alpha administration influences tumour stroma structure and physiology independently of growth in DMBA-induced mammary tumours

Collagen-binding proteoglycan fibromodulin can determine stroma matrix structure and fluid balance in experimental carcinoma

Oldberg, Åke; Kalamajski, Sebastian; Salnikov, Alexei V.; Stuhr, Linda et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 13966-13971, 2007

• DOI for Collagen-binding proteoglycan fibromodulin can determine stroma matrix structure and fluid balance in experimental carcinoma

Control of Interstitial Fluid Homeostasis: Roles of Growth Factors and Integrins

Rubin, Kristofer; Liden, Åsa; Ties, van Wieringen; Reed, Rolf K

Part of Vascular Complications in Human Diseae, p. 106-115, Springer, 2007

Dämpad inflammation gör kemoterapi effektivare

Rubin, Kristofer; Oldberg, Åke; Heldin, Nils-Erik

Part of Onkologi i Sverige, p. 34-41, 2007

Immuno-PET of undifferentiated thyroid carcinoma with radioiodine-labelled antibody cMAb U36: application to antibody tumour uptake studies

Fortin, Marc-André; Salnikov, Alexei V.; Nestor, Marika; Heldin, Nils-Erik et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 1376-1387, 2007

• DOI for Immuno-PET of undifferentiated thyroid carcinoma with radioiodine-labelled antibody cMAb U36: application to antibody tumour uptake studies

2-methoxyestradiol induces apoptosis in cultured human anaplastic thyroid carcinoma cells

Roswall, Pernilla; Bu, Shizhong; Rubin, Kristofer; Landström, Maréne et al.

Part of Thyroid, p. 143-50, 2006

A fibronectin-binding protein from Streptococcus equi binds collagen and modulates cell-mediated collagen gel contraction

Lidén, Åsa; Karlström, Åsa; Lannergård, Jonas; Kalamajski, Sebastian et al.

Part of Biochemical and Biophysical Research Communications, p. 604-610, 2006

A fibronectin-binding protein from Streptococcus equi binds collagen and modulates cell-mediated collagen gel contraction

Lidén, Åsa; Karlström, Åsa; Lannergård, Jonas; Kalamajski, Sebastian et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 604-610, 2006

• DOI for A fibronectin-binding protein from Streptococcus equi binds collagen and modulates cell-mediated collagen gel contraction

An interstitial network of podoplanin-expressing cells in the human endolymphatic duct

Hultgård-Ekwall, Anna-Karin; Mayerl, Christina; Rubin, Kristofer; Wick, Georg et al.

Part of Journal of the Association for Research in Otolaryngology, p. 38-47, 2006

• DOI for An interstitial network of podoplanin-expressing cells in the human endolymphatic duct

High-dose, short-term, anti-inflammatory treatment with dexamethasone reduces growth and augments the effects of 5-fluorouracil on dimethyl-alpha- benzanthracene-induced mammary tumors in rats

Stuhr, L. E. B.; Salnikov, Alexei V.; Iversen, V. V.; Salvesen, G. et al.

Part of Scandinavian Journal of Clinical and Laboratory Investigation, p. 477-486, 2006

• DOI for High-dose, short-term, anti-inflammatory treatment with dexamethasone reduces growth and augments the effects of 5-fluorouracil on dimethyl-alpha- benzanthracene-induced mammary tumors in rats

Inhibition of carcinoma cell-derived VEGF reduces inflammatory characteristics in xenograft carcinoma

Salnikov, Alexei V.; Heldin, Nils-Erik; Stuhr, Linda B.; Wiig, Helge et al.

Part of International Journal of Cancer, p. 2795-2802, 2006

• DOI for Inhibition of carcinoma cell-derived VEGF reduces inflammatory characteristics in xenograft carcinoma

Knockout mouse models have provided invaluable insights into vascular development

Rubin, Kristofer; Salnikov, Alexei; Sundberg, Christian

Part of Encyclopedia of the Microvasculature, p. 1109-1114, Elsevier Academic, San Diego, CA, 2006

Platelet-derived growth factor BB-mediated normalization of dermal interstitial fluid pressure after mast cell degranulation depends on beta3 but not beta1 integrins

Lidén, Åsa; Berg, Ansgar; Nedrebö, Torbjörn; Reed, Rolf K. et al.

Part of Circulation Research, p. 635-641, 2006

• DOI for Platelet-derived growth factor BB-mediated normalization of dermal interstitial fluid pressure after mast cell degranulation depends on beta3 but not beta1 integrins

Inhibition of TGF-beta modulates macrophages and vessel maturation in parallel to a lowering of interstitial fluid pressure in experimental carcinoma

Salnikov, Alexei V.; Roswall, Pernilla; Sundberg, Christian; Gardner, Humphrey et al.

Part of Laboratory Investigation, p. 512-521, 2005

• DOI for Inhibition of TGF-beta modulates macrophages and vessel maturation in parallel to a lowering of interstitial fluid pressure in experimental carcinoma

Analysis of gene expression in fibroblasts in response to keratinocyte-derived factors in vitro:potential implications for the wound healing process

Nowinski, Daniel; Lysheden, Ann-Sophie; Gardner, Humphrey; Rubin, Kristofer et al.

Part of Journal of Investigative Dermatology, p. 216-21, 2004

High interstitial fluid pressure - an obstacle in cancer therapy.

Heldin, Carl-Henrik; Rubin, Kristofer; Pietras, Kristian; Östman, Arne

Part of Nat Rev Cancer, p. 806-13, 2004

Platelet-derived growth factor-BB modulates membrane mobility of beta1 integrins.

Ahlén, Karina; Ring, Patrik; Tomasini-Johansson, Bianca; Holmqvist, Kristina et al.

Part of Biochem Biophys Res Commun, p. 89-96, 2004

Hyaluronan content in experimental carcinoma is not correlated to interstitial fluid pressure.

Jacobson, Annica; Salnikov, Alexei; Lammerts, Ellen; Roswall, Pernilla et al.

Part of Biochem. Biophys. Res. Commun., p. 1017-1023, 2003

Network organization of interstitial connective tissue cells in the human endolymphatic duct

Hultgård Ekwall, Anna-Karin; Couloigner, Vincent; Rubin, Kristofer; Rask-Andersen, Helge

Part of Journal of Histochemistry and Cytochemistry, p. 1491-1500, 2003

Network organization of interstitial connective tissue cells in the human endolymphatic duct

Hultgård-Ekwall, Anna-Karin H; Couloigner, Vincent; Rubin, Kristofer; Rask-Andersen, Helge

Part of Journal of Histochemistry and Cytochemistry, p. 1491-500, 2003

• DOI for Network organization of interstitial connective tissue cells in the human endolymphatic duct

PDGF receptors as cancer drug targets.

Pietras, Kristian; Sjöblom, Tobias; Rubin, Kristofer; Heldin, Carl-Henrik et al.

Part of Cancer Cell, p. 439, 2003

STI571 enhances the therapeutic index of epothilone B by a tumor-selectiveincrease of drug uptake.

Pietras, Kristian; Stumm, Michael; Hubert, Martine; Buchdunger, Elisabeth et al.

Part of Clin Cancer Res, p. 3779, 2003