Publikationer

Inhibition of integrin alpha(V)beta(6) changes fibril thickness of stromal collagen in experimental carcinomas

Olsson, P. Olof; Gustafsson, Renata; Salnikov, Alexei, V; Göthe, Maria et al.

Ingår i Cell Communication and Signaling, 2018

• DOI för Inhibition of integrin alpha(V)beta(6) changes fibril thickness of stromal collagen in experimental carcinomas
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Integrin α_Vβ₃ can substitute for collagen‐binding β₁‐integrins in vivo to maintain a homeostatic interstitial fluid pressure

Liden, Åsa; Karlsen, Tine Veronika; Guss, Bengt; Reed, Rolf K. et al.

Ingår i Experimental Physiology, s. 629-634, 2018

• DOI för Integrin α_Vβ₃ can substitute for collagen‐binding β₁‐integrins in vivo to maintain a homeostatic interstitial fluid pressure
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The endoplasmic reticulum-resident collagen chaperone Hsp47 interacts with and promotes the secretion of decorin, fibromodulin, and lumican

Ishikawa, Yoshihiro; Rubin, Kristofer; Bächinger, Hans Peter; Kalamajski, Sebastian

Ingår i Journal of Biological Chemistry, s. 13707-13716, 2018

• DOI för The endoplasmic reticulum-resident collagen chaperone Hsp47 interacts with and promotes the secretion of decorin, fibromodulin, and lumican

Fibromodulin deficiency reduces collagen structural network but not glycosaminoglycan content in a syngeneic model of colon carcinoma.

Olsson, P Olof; Kalamajski, Sebastian; Maccarana, Marco; Oldberg, Åke et al.

Ingår i PLOS ONE, 2017

• DOI för Fibromodulin deficiency reduces collagen structural network but not glycosaminoglycan content in a syngeneic model of colon carcinoma.
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Imatinib increases oxygen delivery in extracellular matrix-rich but not in matrix-poor experimental carcinoma

Burmakin, Mikhail; van Wieringen, Tijs; Olsson, P. Olof; Stuhr, Linda et al.

Ingår i Journal of Translational Medicine, 2017

• DOI för Imatinib increases oxygen delivery in extracellular matrix-rich but not in matrix-poor experimental carcinoma
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PDGF-BB enhances collagen gel contraction through a PI3K-PLCγ-PKC-cofilin pathway

Reyhani, Vahid; Tsioumpekou, Maria; van Wieringen, Tijs; Rask, Lars et al.

Ingår i Scientific Reports, 2017

• DOI för PDGF-BB enhances collagen gel contraction through a PI3K-PLCγ-PKC-cofilin pathway
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Fibromodulin Interacts with Collagen Cross-linking Sites and Activates Lysyl Oxidase.

Kalamajski, Sebastian; Bihan, Dominique; Bonna, Arkadiusz; Rubin, Kristofer et al.

Ingår i Journal of Biological Chemistry, s. 7951-60, 2016

• DOI för Fibromodulin Interacts with Collagen Cross-linking Sites and Activates Lysyl Oxidase.

Normal oral keratinocytes and head and neck squamous carcinoma cells induce an innate response in fibroblasts

Hakelius, Malin; Reyhani, Vahid; Rubin, Kristofer; Gerdin, Bengt et al.

Ingår i Anticancer Research, s. 2131-2137, 2016

The Tyrosine Kinase Inhibitor Imatinib Augments Extracellular Fluid Exchange and Reduces Average Collagen Fibril Diameter in Experimental Carcinoma

Olsson, P. Olof; Gustafsson, Renata; in 't Zandt, Rene; Friman, Tomas et al.

Ingår i Molecular Cancer Therapeutics, s. 2455-2464, 2016

• DOI för The Tyrosine Kinase Inhibitor Imatinib Augments Extracellular Fluid Exchange and Reduces Average Collagen Fibril Diameter in Experimental Carcinoma

O-15-Water PET Study of the Effect of Imatinib, a Selective Platelet-Derived Growth Factor Receptor Inhibitor, Versus Anakinra, an IL-1R Antagonist, on Water-Perfusable Tissue Fraction in Colorectal Cancer Metastases

Lubberink, Mark; Golla, Sanjeep S. V.; Jonasson, My; Rubin, Kristofer et al.

Ingår i Journal of Nuclear Medicine, s. 1144-1149, 2015

• DOI för O-15-Water PET Study of the Effect of Imatinib, a Selective Platelet-Derived Growth Factor Receptor Inhibitor, Versus Anakinra, an IL-1R Antagonist, on Water-Perfusable Tissue Fraction in Colorectal Cancer Metastases

Fibrin binds to collagen and provides a bridge for alpha V beta 3 integrin-dependent contraction of collagen gels

Reyhani, Vahid; Seddigh, Pegah; Guss, Bengt; Gustafsson, Renata et al.

Ingår i Biochemical Journal, s. 113-123, 2014

• DOI för Fibrin binds to collagen and provides a bridge for alpha V beta 3 integrin-dependent contraction of collagen gels

Increased C-telopeptide Cross-linking of Tendon Type I Collagen in Fibromodulin-deficient Mice

Kalamajski, Sebastian; Liu, Cuiping; Tillgren, Viveka; Rubin, Kristofer et al.

Ingår i Journal of Biological Chemistry, s. 18873-18879, 2014

• DOI för Increased C-telopeptide Cross-linking of Tendon Type I Collagen in Fibromodulin-deficient Mice

Keratinocytes and Head and Neck Squamous Cell Carcinoma Cells Regulate Urokinase-type Plasminogen Activator and Plasminogen Activator Inhibitor-1 in Fibroblasts

Hakelius, Malin; Koskela, Anita; Ivarsson, Mikael; Grenman, Reidar et al.

Ingår i Anticancer Research, s. 3113-3118, 2013

Mice Lacking NCF1 Exhibit Reduced Growth of Implanted Melanoma and Carcinoma Tumors

Kelkka, Tiina; Pizzolla, Angela; Laurila, Juha Petteri; Friman, Tomas et al.

Ingår i PLOS ONE, 2013

• DOI för Mice Lacking NCF1 Exhibit Reduced Growth of Implanted Melanoma and Carcinoma Tumors
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Increased Fibrosis and Interstitial Fluid Pressure in Two Different Types of Syngeneic Murine Carcinoma Grown in Integrin β3-Subunit Deficient Mice

Friman, Tomas; Gustafsson, Renata; Stuhr, Linda B.; Chidiac, Jean et al.

Ingår i PLOS ONE, 2012

• DOI för Increased Fibrosis and Interstitial Fluid Pressure in Two Different Types of Syngeneic Murine Carcinoma Grown in Integrin β3-Subunit Deficient Mice
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Interleukin-1-mediated effects of normal oral keratinocytes and head and neck squamous carcinoma cells on extracellular matrix related gene expression in fibroblasts

Hakelius, Malin; Koskela, Anita; Reyhani, Vahid; Ivarsson, Mikael et al.

Ingår i Oral Oncology, s. 1236-1241, 2012

• DOI för Interleukin-1-mediated effects of normal oral keratinocytes and head and neck squamous carcinoma cells on extracellular matrix related gene expression in fibroblasts

Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner

Xie, Liang; Duncan, Michael B.; Pahler, Jessica; Sugimoto, Hikaru et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 9939-9944, 2011

• DOI för Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner

Edema and fluid dynamics in connective tissue remodelling

Reed, Rolf K.; Lidén, Åsa; Rubin, Kristofer

Ingår i Journal of Molecular and Cellular Cardiology, s. 518-523, 2010

• DOI för Edema and fluid dynamics in connective tissue remodelling

The streptococcal collagen-binding protein CNE specifically interferes with {alpha}V{beta}3-mediated cellular interactions with triple helical collagen

van Wieringen, Tijs; Kalamajski, Sebastian; Lidén, Åsa; Bihan, Dominique et al.

Ingår i Journal of Biological Chemistry, s. 35803-35813, 2010

• DOI för The streptococcal collagen-binding protein CNE specifically interferes with {alpha}V{beta}3-mediated cellular interactions with triple helical collagen

Transcapillary exchange: role and importance of the interstitial fluid pressure and the extracellular matrix

Reed, Rolf K.; Rubin, Kristofer

Ingår i Cardiovascular Research, s. 211-217, 2010

• DOI för Transcapillary exchange: role and importance of the interstitial fluid pressure and the extracellular matrix

Type I interferon system activation and association with disease manifestations in systemic sclerosis

Eloranta, Maija-Leena; Franck-Larsson, Karin; Lövgren, Tanja; Kalamajski, Sebastian et al.

Ingår i Annals of the Rheumatic Diseases, s. 1396-1402, 2010

• DOI för Type I interferon system activation and association with disease manifestations in systemic sclerosis

Combined anti-angiogenic therapy targeting PDGF and VEGF receptors lowers the interstitial fluid pressure in a murine experimental carcinoma

Kłosowska-Wardega, Agnieszka; Hasumi, Yoko; Burmakin, Mikhail; Åhgren, Aive et al.

Ingår i PloS one, 2009

• DOI för Combined anti-angiogenic therapy targeting PDGF and VEGF receptors lowers the interstitial fluid pressure in a murine experimental carcinoma

Integrin α₁β₁ is Involved in the Differentiation into Myofibroblasts in Adult Reactive Tissues in vivo

Rodriguez, Alejandro; Karén, Jakob; Gardner, Humphrey; Gerdin, Bengt et al.

Ingår i Journal of Cellular and Molecular Medicine, s. 3449-3462, 2009

• DOI för Integrin α₁β₁ is Involved in the Differentiation into Myofibroblasts in Adult Reactive Tissues in vivo

Lowered albumin extravasation rate in heart but not in other organs in beta3-integrin-deficient mice

Svendsen, O S; Lidén, A; Rubin, Kristofer; Reed, R K

Ingår i Acta Physiologica, s. 305-311, 2009

• DOI för Lowered albumin extravasation rate in heart but not in other organs in beta3-integrin-deficient mice

Opposite effects of PDGF-BB and prostaglandin E(1) on cell-motility related processes are paralleled by modifications of distinct actin-binding proteins

van Wieringen, Tijs; Kimani, Stanley G.; Hultgard-Ekwall, Anna-Karin; Forsberg, Jens et al.

Ingår i Experimental Cell Research, s. 1745-1758, 2009

• DOI för Opposite effects of PDGF-BB and prostaglandin E(1) on cell-motility related processes are paralleled by modifications of distinct actin-binding proteins

A secreted collagen- and fibronectin-binding streptococcal protein modulates cell-mediated collagen gel contraction and interstitial fluid pressure

Lidén, Åsa; van Wieringen, Tijs; Lannergård, Jonas; Kassner, Anja et al.

Ingår i Journal of Biological Chemistry, s. 1234-1242, 2008

• DOI för A secreted collagen- and fibronectin-binding streptococcal protein modulates cell-mediated collagen gel contraction and interstitial fluid pressure

Integrin alphavbeta3 acts downstream of insulin in normalization of interstitial fluid pressure in sepsis and in cell-mediated collagen gel contraction

Svendsen, Oyvind Sverre; Lidén, Asa; Nedrebø, Torbjørn; Rubin, Kristofer et al.

Ingår i American Journal of Physiology. Heart and Circulatory Physiology, 2008

• DOI för Integrin alphavbeta3 acts downstream of insulin in normalization of interstitial fluid pressure in sepsis and in cell-mediated collagen gel contraction

Peritumoral TNF alpha administration influences tumour stroma structure and physiology independently of growth in DMBA-induced mammary tumours

Stuhr, Linda E. B.; Moen, Ingrid; Nedrebo, Torbjorn; Salnikov, Alexei V. et al.

Ingår i Scandinavian Journal of Clinical and Laboratory Investigation, s. 602-611, 2008

• DOI för Peritumoral TNF alpha administration influences tumour stroma structure and physiology independently of growth in DMBA-induced mammary tumours

Collagen-binding proteoglycan fibromodulin can determine stroma matrix structure and fluid balance in experimental carcinoma

Oldberg, Åke; Kalamajski, Sebastian; Salnikov, Alexei V.; Stuhr, Linda et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 13966-13971, 2007

• DOI för Collagen-binding proteoglycan fibromodulin can determine stroma matrix structure and fluid balance in experimental carcinoma

Control of Interstitial Fluid Homeostasis: Roles of Growth Factors and Integrins

Rubin, Kristofer; Liden, Åsa; Ties, van Wieringen; Reed, Rolf K

Ingår i Vascular Complications in Human Diseae, s. 106-115, Springer, 2007

Dämpad inflammation gör kemoterapi effektivare

Rubin, Kristofer; Oldberg, Åke; Heldin, Nils-Erik

Ingår i Onkologi i Sverige, s. 34-41, 2007

Immuno-PET of undifferentiated thyroid carcinoma with radioiodine-labelled antibody cMAb U36: application to antibody tumour uptake studies

Fortin, Marc-André; Salnikov, Alexei V.; Nestor, Marika; Heldin, Nils-Erik et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 1376-1387, 2007

• DOI för Immuno-PET of undifferentiated thyroid carcinoma with radioiodine-labelled antibody cMAb U36: application to antibody tumour uptake studies

2-methoxyestradiol induces apoptosis in cultured human anaplastic thyroid carcinoma cells

Roswall, Pernilla; Bu, Shizhong; Rubin, Kristofer; Landström, Maréne et al.

Ingår i Thyroid, s. 143-50, 2006

A fibronectin-binding protein from Streptococcus equi binds collagen and modulates cell-mediated collagen gel contraction

Lidén, Åsa; Karlström, Åsa; Lannergård, Jonas; Kalamajski, Sebastian et al.

Ingår i Biochemical and Biophysical Research Communications, s. 604-610, 2006

A fibronectin-binding protein from Streptococcus equi binds collagen and modulates cell-mediated collagen gel contraction

Lidén, Åsa; Karlström, Åsa; Lannergård, Jonas; Kalamajski, Sebastian et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 604-610, 2006

• DOI för A fibronectin-binding protein from Streptococcus equi binds collagen and modulates cell-mediated collagen gel contraction

An interstitial network of podoplanin-expressing cells in the human endolymphatic duct

Hultgård-Ekwall, Anna-Karin; Mayerl, Christina; Rubin, Kristofer; Wick, Georg et al.

Ingår i Journal of the Association for Research in Otolaryngology, s. 38-47, 2006

• DOI för An interstitial network of podoplanin-expressing cells in the human endolymphatic duct

High-dose, short-term, anti-inflammatory treatment with dexamethasone reduces growth and augments the effects of 5-fluorouracil on dimethyl-alpha- benzanthracene-induced mammary tumors in rats

Stuhr, L. E. B.; Salnikov, Alexei V.; Iversen, V. V.; Salvesen, G. et al.

Ingår i Scandinavian Journal of Clinical and Laboratory Investigation, s. 477-486, 2006

• DOI för High-dose, short-term, anti-inflammatory treatment with dexamethasone reduces growth and augments the effects of 5-fluorouracil on dimethyl-alpha- benzanthracene-induced mammary tumors in rats

Inhibition of carcinoma cell-derived VEGF reduces inflammatory characteristics in xenograft carcinoma

Salnikov, Alexei V.; Heldin, Nils-Erik; Stuhr, Linda B.; Wiig, Helge et al.

Ingår i International Journal of Cancer, s. 2795-2802, 2006

• DOI för Inhibition of carcinoma cell-derived VEGF reduces inflammatory characteristics in xenograft carcinoma

Knockout mouse models have provided invaluable insights into vascular development

Rubin, Kristofer; Salnikov, Alexei; Sundberg, Christian

Ingår i Encyclopedia of the Microvasculature, s. 1109-1114, Elsevier Academic, San Diego, CA, 2006

Platelet-derived growth factor BB-mediated normalization of dermal interstitial fluid pressure after mast cell degranulation depends on beta3 but not beta1 integrins

Lidén, Åsa; Berg, Ansgar; Nedrebö, Torbjörn; Reed, Rolf K. et al.

Ingår i Circulation Research, s. 635-641, 2006

• DOI för Platelet-derived growth factor BB-mediated normalization of dermal interstitial fluid pressure after mast cell degranulation depends on beta3 but not beta1 integrins

Inhibition of TGF-beta modulates macrophages and vessel maturation in parallel to a lowering of interstitial fluid pressure in experimental carcinoma

Salnikov, Alexei V.; Roswall, Pernilla; Sundberg, Christian; Gardner, Humphrey et al.

Ingår i Laboratory Investigation, s. 512-521, 2005

• DOI för Inhibition of TGF-beta modulates macrophages and vessel maturation in parallel to a lowering of interstitial fluid pressure in experimental carcinoma

Analysis of gene expression in fibroblasts in response to keratinocyte-derived factors in vitro:potential implications for the wound healing process

Nowinski, Daniel; Lysheden, Ann-Sophie; Gardner, Humphrey; Rubin, Kristofer et al.

Ingår i Journal of Investigative Dermatology, s. 216-21, 2004

High interstitial fluid pressure - an obstacle in cancer therapy.

Heldin, Carl-Henrik; Rubin, Kristofer; Pietras, Kristian; Östman, Arne

Ingår i Nat Rev Cancer, s. 806-13, 2004

Platelet-derived growth factor-BB modulates membrane mobility of beta1 integrins.

Ahlén, Karina; Ring, Patrik; Tomasini-Johansson, Bianca; Holmqvist, Kristina et al.

Ingår i Biochem Biophys Res Commun, s. 89-96, 2004

Hyaluronan content in experimental carcinoma is not correlated to interstitial fluid pressure.

Jacobson, Annica; Salnikov, Alexei; Lammerts, Ellen; Roswall, Pernilla et al.

Ingår i Biochem. Biophys. Res. Commun., s. 1017-1023, 2003

Network organization of interstitial connective tissue cells in the human endolymphatic duct

Hultgård Ekwall, Anna-Karin; Couloigner, Vincent; Rubin, Kristofer; Rask-Andersen, Helge

Ingår i Journal of Histochemistry and Cytochemistry, s. 1491-1500, 2003

Network organization of interstitial connective tissue cells in the human endolymphatic duct

Hultgård-Ekwall, Anna-Karin H; Couloigner, Vincent; Rubin, Kristofer; Rask-Andersen, Helge

Ingår i Journal of Histochemistry and Cytochemistry, s. 1491-500, 2003

• DOI för Network organization of interstitial connective tissue cells in the human endolymphatic duct

PDGF receptors as cancer drug targets.

Pietras, Kristian; Sjöblom, Tobias; Rubin, Kristofer; Heldin, Carl-Henrik et al.

Ingår i Cancer Cell, s. 439, 2003

STI571 enhances the therapeutic index of epothilone B by a tumor-selectiveincrease of drug uptake.

Pietras, Kristian; Stumm, Michael; Hubert, Martine; Buchdunger, Elisabeth et al.

Ingår i Clin Cancer Res, s. 3779, 2003

Expression of hyaluronan synthase 2 or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors.

Jacobson, Annica; Rahmanian, Mehdi; Rubin, Kristofer; Heldin, Paraskevi

Ingår i Int J Cancer, s. 212, 2002