Analytical Pharmaceutical Chemistry

Development and validation of LC-MS/MS methods for the pharmacokinetic assessment of the PROTACs bavdeglutamide (ARV-110) and vepdegestrant (ARV-471)

Niessen, Janis; Nilsson, Jenny M.; Peters, Karsten; Indulkar, Anura et al.

Part of Journal of Pharmaceutical and Biomedical Analysis, 2024

• DOI for Development and validation of LC-MS/MS methods for the pharmacokinetic assessment of the PROTACs bavdeglutamide (ARV-110) and vepdegestrant (ARV-471)
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Elevated Plasma Levels of Arginines During Labor Among Women with Spontaneous Preterm Birth: A Prospective Cohort Study

Akhter, Tansim; Hedeland, Mikael; Bergquist, Jonas; Ubhayasekera, Kumari et al.

Part of American Journal of Reproductive Immunology, 2024

• DOI for Elevated Plasma Levels of Arginines During Labor Among Women with Spontaneous Preterm Birth: A Prospective Cohort Study
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Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells

Kopsida, Maria; Clavero, Ada Lerma; Khaled, Jaafar; Balgoma, David et al.

Part of Molecular Metabolism, 2024

• DOI for Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells
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Metabolite Profiling of Drugs using Mass Spectrometry: Identification of analytical targets for doping control and improvements of the metabolite search process

Nilsson Broberg, Malin

2024

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A multivariate data analysis approach for the investigation of in vitro derived metabolites of ACP-105 in comparison with human in vivo metabolites

Nilsson Broberg, Malin; Tillgren Ohlsson, Rebecca; Bondesson, Ulf; Pettersson, Curt et al.

Part of Journal of chromatography. B, 2023

• DOI for A multivariate data analysis approach for the investigation of in vitro derived metabolites of ACP-105 in comparison with human in vivo metabolites
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An interlaboratory capillary zone electrophoresis-UV study of various monoclonal antibodies, instruments, and ε-aminocaproic acid lots

Wiesner, Rebecca; Zagst, Holger; Lan, Wenkui; Bigelow, Stewart et al.

Part of Electrophoresis, p. 1247-1257, 2023

• DOI for An interlaboratory capillary zone electrophoresis-UV study of various monoclonal antibodies, instruments, and ε-aminocaproic acid lots
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Combining the targeted and untargeted screening of environmental contaminants reveals associations between PFAS exposure and vitamin D metabolism in human plasma.

Carlsson, Henrik; Sreenivasan, Akshai P.; Erngren, Ida; Larsson, Anders et al.

Part of Environmental Science, p. 1116-1130, 2023

• DOI for Combining the targeted and untargeted screening of environmental contaminants reveals associations between PFAS exposure and vitamin D metabolism in human plasma.
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DNA integrity under alkaline conditions: An investigation of factors affecting the comet assay

Bivehed, Erik; Hellman, Björn; Fan, Yuting; Haglöf, Jakob et al.

Part of Mutation research. Genetic toxicology and environmental mutagenesis, 2023

• DOI for DNA integrity under alkaline conditions: An investigation of factors affecting the comet assay
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Enantiomeric Separation of Triacylglycerols from Mouse Liver Tissue using CSP-LC-MS/MS

Landström, Sofia

2023

Equine in vivo metabolite profiling of the selective androgen receptor modulator LGD-3303 for doping control

Nilsson Broberg, Malin; Knych, Heather; Bondesson, Ulf; Pettersson, Curt et al.

Part of Journal of Pharmaceutical and Biomedical Analysis, 2023

• DOI for Equine in vivo metabolite profiling of the selective androgen receptor modulator LGD-3303 for doping control
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Functionalization of cellulose nanofibrils to develop novel ROS-sensitive biomaterials

Palo-Nieto, Carlos; Blasi-Romero, Anna; Sandström, Corine; Balgoma, David et al.

Part of Materials Advances, p. 1555-1565, 2023

• DOI for Functionalization of cellulose nanofibrils to develop novel ROS-sensitive biomaterials
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Identification and Structural Elucidation of Cannabinoid Metabolites in Horse Urine Using UHPLC-HRMS

Morén, Agnes

2023

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Investigation of degradation of toxic substances in fungal cultures by mass spectrometric techniques

Stenholm, Åke

2023

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Optimization of a Microsome Incubation Method using Design of Experiment and Investigation of Metabolites Derived from GLPG0492 and LY2452473: For Application in Doping Control

Tillgren Ohlsson, Rebecca

2023

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Plasma levels of arginines at term pregnancy in relation to mode of onset of labor and mode of childbirth

Akhter, Tansim; Hedeland, Mikael; Bergquist, Jonas; Ubhayasekera, Kumari et al.

Part of American Journal of Reproductive Immunology, 2023

• DOI for Plasma levels of arginines at term pregnancy in relation to mode of onset of labor and mode of childbirth
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Recent capillary electrophoresis applications for upstream and downstream biopharmaceutical process monitoring

van der Burg, Debbie; Josefsson, Leila; Emmer, Åsa; Sänger–van de Griend, Cari E.

Part of TrAC. Trends in analytical chemistry, 2023

• DOI for Recent capillary electrophoresis applications for upstream and downstream biopharmaceutical process monitoring
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Screening of HETP test conditions and resin storage solutions for HIC

Ronnerfors, Lise-Lotte

2023

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Strategies for capillary electrophoresis: Method development and validation for pharmaceutical and biological applications-Updated and completely revised edition

Krebs, Finja; Zagst, Holger; Stein, Matthias; Ratih, Ratih et al.

Part of Electrophoresis, p. 1279-1341, 2023

• DOI for Strategies for capillary electrophoresis: Method development and validation for pharmaceutical and biological applications-Updated and completely revised edition
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Trials and tribulations of statistical significance in biochemistry and omics

Montero, Olimpio; Hedeland, Mikael; Balgoma, David

Part of TIBS -Trends in Biochemical Sciences. Regular ed., p. 503-512, 2023

• DOI for Trials and tribulations of statistical significance in biochemistry and omics
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Ammonia Concentration in the Eluent Influences Fragmentation Pattern of Triacylglycerols in Mass Spectrometry Analysis

Velasco, Marta; Balgoma, David; Montero, Olimpio

Part of Metabolites, 2022

• DOI for Ammonia Concentration in the Eluent Influences Fragmentation Pattern of Triacylglycerols in Mass Spectrometry Analysis
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Analytical Quality by Design Method Development for Vaccine Characterization

Geurink, Lars

2022

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Comprehensive Peak Characterization (CPC) in Untargeted LC-MS Analysis

Pirttilä, Kristian; Balgoma, David; Rainer, Johannes; Pettersson, Curt et al.

Part of Metabolites, 2022

• DOI for Comprehensive Peak Characterization (CPC) in Untargeted LC-MS Analysis
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Concentration of carprofen in the milk of lactating bitches after cesarean section and during inflammatory conditions

Ferrari, Desiree; Lundgren, Sandra; Holmberg, Johanna; Edner, Anna et al.

Part of Theriogenology, p. 59-68, 2022

• DOI for Concentration of carprofen in the milk of lactating bitches after cesarean section and during inflammatory conditions

Developing reactive oxygen species-sensitive cellulose nanofibers for chronic wound care

Palo Nieto, Carlos; Blasi Romero, Anna; Balgoma, David; Hedeland, Mikael et al.

2022

Development and Validation of a Quantitative UHPLC-MS-MS Method for the Determination of Alpha-Chloralose in Feline Blood and Application on Blood Samples Collected from Cats with Symptoms of Alpha-Chloralose Poisoning

Windahl, Ulrika; Lundgren, Sandra; Sprycha, Margareta; Tegner, Cecilia et al.

Part of Journal of Analytical Toxicology, p. 651-657, 2022

• DOI for Development and Validation of a Quantitative UHPLC-MS-MS Method for the Determination of Alpha-Chloralose in Feline Blood and Application on Blood Samples Collected from Cats with Symptoms of Alpha-Chloralose Poisoning
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Development of analytical methods for the determination of the small molecule component of complex biological systems

Pirttilä, Kristian

2022

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Investigation of neomycin biodegradation conditions using ericoid mycorrhizal and white rot fungal species

Stenholm, Åke; Hedeland, Mikael; Pettersson, Curt

Part of BMC Biotechnology, 2022

• DOI for Investigation of neomycin biodegradation conditions using ericoid mycorrhizal and white rot fungal species
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Method development for mono- and disaccharides monitoring in cell culture medium by capillary and microchip electrophoresis

van der Burg, Debbie; Josefsson, Leila; Mikkonen, Saara; Chotteau, Veronique et al.

Part of Electrophoresis, p. 922-929, 2022

• DOI for Method development for mono- and disaccharides monitoring in cell culture medium by capillary and microchip electrophoresis
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Neomycin removal using the white rot fungus Trametes versicolor

Stenholm, Åke; Hedeland, Mikael; Pettersson, Curt

Part of Journal of Environmental Science and Health. Part A, p. 436-447, 2022

• DOI for Neomycin removal using the white rot fungus Trametes versicolor
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Oceanographic setting influences the prokaryotic community and metabolome in deep-sea sponges

Steffen, Karin; Indraningrat, Anak Agung Gede; Erngren, Ida; Haglöf, Jakob et al.

Part of Scientific Reports, 2022

• DOI for Oceanographic setting influences the prokaryotic community and metabolome in deep-sea sponges
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On the introduction of reactive oxygen species-sensitive linkers onto cellulose nanofibrils: Towards advanced wound healing solutions.

Palo-Nieto, Carlos; Blasi Romero, Anna; Balgoma, David; Strömme, Maria et al.

2022

Oogenesis and lipid metabolism in the deep-sea sponge Phakellia ventilabrum (Linnaeus, 1767)

Koutsouveli, Vasiliki; Balgoma, David; Checa, Antonio; Hedeland, Mikael et al.

Part of Scientific Reports, 2022

• DOI for Oogenesis and lipid metabolism in the deep-sea sponge Phakellia ventilabrum (Linnaeus, 1767)
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Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding

Balgoma, David; Kullenberg, Fredrik; Peters, Karsten; Dahlgren, David et al.

Part of Metabolites, 2022

• DOI for Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding
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Plasma atropine concentrations associated with decreased intestinal motility in horses

Ekstrand, Carl; Michanek, Peter; Gehring, Ronette; Sundell, Anna et al.

Part of Frontiers in Veterinary Science, 2022

• DOI for Plasma atropine concentrations associated with decreased intestinal motility in horses
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Protein mapping of peanut extract with capillary electrophoresis

Villemet, Loic; Cuchet, Aurelien; Desvignes, Christophe; Sänger van de Griend, Catharina

Part of Electrophoresis, p. 1027-1034, 2022

• DOI for Protein mapping of peanut extract with capillary electrophoresis
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Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival

Sennefelt Nyman, Sofi; Ahlström, Håkan; Dimopoulou, Angeliki; Dahlgren, David et al.

Part of BMJ Open, 2022

• DOI for Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival
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The optimization of a manual dissolution method and its equivalence to automated dissolution

Cicek, Diana

2022

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A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma

Nylund, Patrick; Atienza Párraga, Alba; Haglöf, Jakob; De Bruyne, Elke et al.

Part of Cell Death and Disease, 2021

• DOI for A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma
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A high-throughput method for screening of protein binding behavior of multimodal anionic exchange ligands

Avedis, Ani

2021

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Analytical method development in liquid chromatography- mass spectrometry based metabolomics

Erngren, Ida

2021

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Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death

Balgoma, David; Kullenberg, Fredrik; Calitz, Carlemi; Kopsida, Maria et al.

Part of Cells, 2021

• DOI for Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death
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Automated Sequential Analysis of Hydrophilic and Lipophilic Fractions of Biological Samples: Increasing Single-Injection Chemical Coverage in Untargeted Metabolomics

Pirttilä, Kristian; Laurell, Göran; Pettersson, Curt; Hedeland, Mikael

Part of Metabolites, 2021

• DOI for Automated Sequential Analysis of Hydrophilic and Lipophilic Fractions of Biological Samples: Increasing Single-Injection Chemical Coverage in Untargeted Metabolomics
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Dimethylarginines correlate to common carotid artery wall layer dimensions and cardiovascular risk factors in pregnant women with/without preeclampsia: A group comparative study

Akhter, Tansim; Wikström, Gerhard; Larsson, Marita; Bondesson, Ulf et al.

Part of European Journal of Obstetrics, Gynecology, and Reproductive Biology, p. 288-293, 2021

• DOI for Dimethylarginines correlate to common carotid artery wall layer dimensions and cardiovascular risk factors in pregnant women with/without preeclampsia: A group comparative study
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Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats

Dahlgren, David; Olander, Tobias; Sjöblom, Markus; Hedeland, Mikael et al.

Part of Acta Pharmaceutica Sinica B, p. 1667-1675, 2021

• DOI for Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats
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Etherglycerophospholipids and ferroptosis: structure, regulation, and location

Balgoma, David; Hedeland, Mikael

Part of Trends in endocrinology and metabolism, p. 960-962, 2021

• DOI for Etherglycerophospholipids and ferroptosis: structure, regulation, and location
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Four-step approach to efficiently develop capillary gel electrophoresis methods for viral vaccine protein analysis

Geurink, Lars; van Tricht, Ewoud; Dudink, Justin; Pajic, Bojana et al.

Part of Electrophoresis, p. 10-18, 2021

• DOI for Four-step approach to efficiently develop capillary gel electrophoresis methods for viral vaccine protein analysis

Improved sensitivity in hydrophilic interaction liquid chromatography-electrospray-mass spectrometry after removal of sodium and potassium ions from biological samples

Erngren, Ida; Nestor, Marika; Pettersson, Curt; Hedeland, Mikael

Part of Metabolites, 2021

• DOI for Improved sensitivity in hydrophilic interaction liquid chromatography-electrospray-mass spectrometry after removal of sodium and potassium ions from biological samples
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In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma

Kullenberg, Fredrik; Degerstedt, Oliver; Calitz, Carlemi; Pavlovic, Natasa et al.

Part of Cells, 2021

• DOI for In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma
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Investigation of Equine In Vivo and In Vitro Derived Metabolites of the Selective Androgen Receptor Modulator (SARM) ACP-105 for Improved Doping Control

Nilsson Broberg, Malin; Knych, Heather; Bondesson, Ulf; Pettersson, Curt et al.

Part of Metabolites, 2021

• DOI for Investigation of Equine In Vivo and In Vitro Derived Metabolites of the Selective Androgen Receptor Modulator (SARM) ACP-105 for Improved Doping Control
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Modification and validation of the Endopep-mass spectrometry method for botulinum neurotoxin detection in liver samples with application to samples collected during animal botulism outbreaks

Tevell Åberg, Annica; Karlsson, Ida; Hedeland, Mikael

Part of Analytical and Bioanalytical Chemistry, p. 345-354, 2021

• DOI for Modification and validation of the Endopep-mass spectrometry method for botulinum neurotoxin detection in liver samples with application to samples collected during animal botulism outbreaks
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