Pharmacokinetics and Pharmacodynamics

Our goal is to characterize relationships between dose, exposure and effects through experimental and quantitative methods in support of the development as well as usage of efficacious and safe drug treatment. Efficacious and safe treatment requires the achievement of a therapeutic drug concentration at the target-site for a sufficient duration after its administration to a patient.
The recommendation of an optimal dosing regimen for a given patient/patient population requires input from preclinical and clinical investigations focusing on the pharmacokinetic (exposure) and pharmacodynamic (response) characteristics of a drug in healthy and pathological conditions.
The PKPD group is a hub for more than 20 researchers, post-docs, post-graduate and graduate students working within two research branches:
Predictive PKPD led by Professor Lena Friberg.
Translational PKPD led by Associate Professor Irena Loryan.
Predictive Pharmacokinetics and Pharmacodynamics
Our research in Predictive Pharmacokinetics and Pharmacodynamics focuses on characterizing and quantifying dose-concentration-effect/toxicity relationships for new and existing drugs against bacterial infections and various types of cancer.

Translational Pharmacokinetics and Pharmacodynamics
Our research focuses on understanding the fundamental aspects of pharmacokinetics-pharmacodynamics (PKPD) in health and disease focused on central and peripheral nervous systems.

Contact
- Visiting Address: BMC, Husargatan 3, A1:2, A2:2, A3:3, B3:3, B3:4, C2:2
- Letter and Postal Address: Box 580, SE-751 23 Uppsala