Drug delivery

Digoxin Pharmacokinetics in Patients with Obesity Before and After a Gastric Bypass or a Strict Diet Compared with Normal Weight Individuals

Kvitne, Kine Eide; Hovd, Markus; Johnson, Line Kristin; Wegler, Christine et al.

Part of Clinical Pharmacokinetics, p. 109-120, 2024

• DOI for Digoxin Pharmacokinetics in Patients with Obesity Before and After a Gastric Bypass or a Strict Diet Compared with Normal Weight Individuals
• Download full text (pdf) of Digoxin Pharmacokinetics in Patients with Obesity Before and After a Gastric Bypass or a Strict Diet Compared with Normal Weight Individuals

Expression of intestinal drug transporter proteins and metabolic enzymes in neonatal and pediatric patients

de Waal, Tom; Handin, Niklas; Brouwers, Joachim; Miserez, Marc et al.

Part of International Journal of Pharmaceutics, 2024

• DOI for Expression of intestinal drug transporter proteins and metabolic enzymes in neonatal and pediatric patients

Global ¹³C tracing and metabolic flux analysis of intact human liver tissue ex vivo

Grankvist, Nina; Jönsson, Cecilia; Hedin, Karin; Sundqvist, Nicolas et al.

Part of Nature Metabolism, 2024

• DOI for Global ¹³C tracing and metabolic flux analysis of intact human liver tissue ex vivo
• Download full text (pdf) of Global ¹³C tracing and metabolic flux analysis of intact human liver tissue ex vivo

Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates

Yee, Sook Wah; Ferrández-Peral, Luis; Alentorn-Moron, Pol; Fontsere, Claudia et al.

Part of Nature Communications, 2024

• DOI for Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates
• Download full text (pdf) of Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates

In silico and biological analyses of missense variants of the human biliary efflux transporter ABCC2: effects of novel rare missense variants

Kölz, Charlotte; Gaugaz, Fabienne Z.; Handin, Niklas; Schaeffeler, Elke et al.

Part of British Journal of Pharmacology, 2024

• DOI for In silico and biological analyses of missense variants of the human biliary efflux transporter ABCC2: effects of novel rare missense variants

OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids

Mickols, Evgeniya; Meyer, Alina; Handin, Niklas; Stüwe, Malin et al.

Part of Scientific Reports, 2024

• DOI for OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids
• Download full text (pdf) of OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids

The choice of ultra-low attachment plates impacts primary human and primary canine hepatocyte spheroid formation, phenotypes, and function

Xing, Chen; Kemas, Aurino; Mickols, Evgeniya; Klein, Kathrin et al.

Part of Biotechnology Journal, 2024

• DOI for The choice of ultra-low attachment plates impacts primary human and primary canine hepatocyte spheroid formation, phenotypes, and function
• Download full text (pdf) of The choice of ultra-low attachment plates impacts primary human and primary canine hepatocyte spheroid formation, phenotypes, and function

Epithelial and microbial determinants of colonic drug distribution

Hammar, Rebekkah; Sellin, Mikael E.; Artursson, Per

Part of European Journal of Pharmaceutical Sciences, 2023

• DOI for Epithelial and microbial determinants of colonic drug distribution
• Download full text (pdf) of Epithelial and microbial determinants of colonic drug distribution

Neither Gastric Bypass Surgery Nor Diet-Induced Weight-Loss Affect OATP1B1 Activity as Measured by Rosuvastatin Oral Clearance

Hovd, Markus; Robertsen, Ida; Johnson, Line Kristin; Krogstad, Veronica et al.

Part of Clinical Pharmacokinetics, p. 725-735, 2023

• DOI for Neither Gastric Bypass Surgery Nor Diet-Induced Weight-Loss Affect OATP1B1 Activity as Measured by Rosuvastatin Oral Clearance
• Download full text (pdf) of Neither Gastric Bypass Surgery Nor Diet-Induced Weight-Loss Affect OATP1B1 Activity as Measured by Rosuvastatin Oral Clearance

Proteome deconvolution of liver biopsies reveals hepatic cell composition as an important marker of fibrosis

Handin, Niklas; Yuan, Di; Olander, Magnus; Wegler, Christine et al.

Part of Computational and Structural Biotechnology Journal, p. 4361-4369, 2023

• DOI for Proteome deconvolution of liver biopsies reveals hepatic cell composition as an important marker of fibrosis
• Download full text (pdf) of Proteome deconvolution of liver biopsies reveals hepatic cell composition as an important marker of fibrosis

Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat

Lundquist, Patrik; Khodus, Georgiy; Niu, Zhigao; Thwala, Lungile Nomcebo et al.

Part of ACS Nano, p. 14210-14229, 2022

• DOI for Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat
• Download full text 1 (pdf) of Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat
• Download full text 2 (pdf) of Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat

Correlations between 4 beta-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range

Kvitne, Kine Eide; Hole, Kristine; Krogstad, Veronica; Wollmann, Birgit Malene et al.

Part of European Journal of Clinical Pharmacology, p. 1289-1299, 2022

• DOI for Correlations between 4 beta-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range
• Download full text (pdf) of Correlations between 4 beta-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range

Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity

Wegler, Christine; Wiśniewski, Jacek R; Robertsen, Ida; Christensen, Hege et al.

Part of Clinical Pharmacology and Therapeutics, p. 1142-1154, 2022

• DOI for Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity
• Download full text (pdf) of Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity

Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation

Tremmel, Roman; Nies, Anne T.; van Eijck, Barbara A. C.; Handin, Niklas et al.

Part of International Journal of Molecular Sciences, 2022

• DOI for Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation
• Download full text (pdf) of Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation

High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3

Chen, Eugene C.; Matsson, Pär; Azimi, Mina; Zhou, Xujia et al.

Part of Pharmaceutical research, p. 1599-1613, 2022

• DOI for High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3
• Download full text (pdf) of High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3

Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity

Kvitne, Kine Eide; Asberg, Anders; Johnson, Line K.; Wegler, Christine et al.

Part of Clinical and Translational Science, p. 2685-2696, 2022

• DOI for Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity
• Download full text (pdf) of Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity

Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration

Hellinen, Laura; Koskela, Ali; Vattulainen, Elina; Liukkonen, Mikko et al.

Part of Biomedicine and Pharmacotherapy, 2022

• DOI for Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration
• Download full text (pdf) of Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration

Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ

Al-Amin, Rasel A.; Johansson, Lars; Abdurakhmanov, Eldar; Landegren, Nils et al.

Part of Nucleic Acids Research, 2022

• DOI for Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ
• Download full text (pdf) of Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ

Professor Margareta Hammarlund-Udenaes - Humbled Scientist Shaping Modern Neuropharmacokinetics

Loryan, Irena; Smith, David E.; Artursson, Per; Breimer, Douwe et al.

Part of Pharmaceutical research, p. 1283-1289, 2022

• DOI for Professor Margareta Hammarlund-Udenaes - Humbled Scientist Shaping Modern Neuropharmacokinetics

Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity

Kvitne, Kine Eide; Krogstad, Veronica; Wegler, Christine; Johnson, Line Kristin et al.

Part of British Journal of Clinical Pharmacology, p. 4121-4133, 2022

• DOI for Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity
• Download full text (pdf) of Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity

Short- and long-term effects of body weight loss following calorie restriction and gastric bypass on CYP3A-activity: a non-randomized three-armed controlled trial

Kvitne, Kine Eide; Robertsen, Ida; Skovlund, Eva; Christensen, Hege et al.

Part of Clinical and Translational Science, p. 221-233, 2022

• DOI for Short- and long-term effects of body weight loss following calorie restriction and gastric bypass on CYP3A-activity: a non-randomized three-armed controlled trial
• Download full text (pdf) of Short- and long-term effects of body weight loss following calorie restriction and gastric bypass on CYP3A-activity: a non-randomized three-armed controlled trial

The impact of inflammation on the expression of drug transporters and metabolic enzymes in colonic tissue from ulcerative colitis patients

de Waal, Tom; Handin, Niklas; Brouwers, Joachim; Ferrante, Marc et al.

Part of International Journal of Pharmaceutics, 2022

• DOI for The impact of inflammation on the expression of drug transporters and metabolic enzymes in colonic tissue from ulcerative colitis patients

Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis

Kundu, Snehangshu; Ali, Muhammad Akhtar; Handin, Niklas; Conway, Louis P. et al.

Part of Journal of Experimental & Clinical Cancer Research, 2021

• DOI for Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis
• Download full text (pdf) of Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis

Conditions for maintenance of hepatocyte differentiation and function in 3D cultures

Handin, Niklas; Mickols, Evgeniya; Ölander, Magnus; Rudfeldt, Jakob et al.

Part of iScience, 2021

• DOI for Conditions for maintenance of hepatocyte differentiation and function in 3D cultures
• Download full text (pdf) of Conditions for maintenance of hepatocyte differentiation and function in 3D cultures

Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network

Vinarov, Zahari; Abrahamsson, Bertil; Artursson, Per; Batchelor, Hannah et al.

Part of Advanced Drug Delivery Reviews, p. 289-331, 2021

• DOI for Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network
• Download full text (pdf) of Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network

Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1

Wegler, Christine; Gazit, Meryem; Issa, Karolina; Subramaniam, Sujay et al.

Part of Journal of Pharmaceutical Sciences, p. 388-396, 2021

• DOI for Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1
• Download full text (pdf) of Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1

Getting a grip with kirigami

Teleki, Alexandra; Artursson, Per

Part of Nature Materials, p. 1043-1044, 2021

• DOI for Getting a grip with kirigami

Hepatocyte size fractionation allows dissection of human liver zonation

Ölander, Magnus; Wegler, Christine; Flörkemeier, Inken; Treyer, Andrea et al.

Part of Journal of Cellular Physiology, p. 5885-5894, 2021

• DOI for Hepatocyte size fractionation allows dissection of human liver zonation
• Download full text (pdf) of Hepatocyte size fractionation allows dissection of human liver zonation

Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes

Wegler, Christine; Matsson, Pär; Krogstad, Veronica; Urdzik, Jozef et al.

Part of Molecular Pharmaceutics, p. 1792-1805, 2021

• DOI for Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes
• Download full text (pdf) of Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes

Newly developed dual topoisomerase inhibitor P8-D6 is highly active in ovarian cancer

Flörkemeier, Inken; Steinhauer, Tamara N.; Hedemann, Nina; Ölander, Magnus et al.

Part of THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2021

• DOI for Newly developed dual topoisomerase inhibitor P8-D6 is highly active in ovarian cancer
• Download full text (pdf) of Newly developed dual topoisomerase inhibitor P8-D6 is highly active in ovarian cancer

Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease

Asad, Shno; Wegler, Christine; Ahl, David; Bergström, Christel A. S. et al.

Part of Journal of Pharmaceutical Sciences, p. 239-250, 2021

• DOI for Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease
• Download full text (pdf) of Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease

Proteomics‐Informed Prediction of Rosuvastatin Plasma Profiles in Patients with a Wide Range of Body Weight

Wegler, Christine; Prieto Garcia, Luna; Klinting, Signe; Robertsen, Ida et al.

Part of Clinical Pharmacology and Therapeutics, p. 762-771, 2021

• DOI for Proteomics‐Informed Prediction of Rosuvastatin Plasma Profiles in Patients with a Wide Range of Body Weight
• Download full text (pdf) of Proteomics‐Informed Prediction of Rosuvastatin Plasma Profiles in Patients with a Wide Range of Body Weight

A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity

Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K. et al.

Part of Drug Metabolism And Disposition, p. 8-17, 2020

• DOI for A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity

A new opening for orally taken peptide drugs

Artursson, Per; Lundquist, Patrik

Part of Nature Biomedical Engineering, p. 12-13, 2020

• DOI for A new opening for orally taken peptide drugs

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions

Antonescu, Irina E.; Karlgren, Maria; Pedersen, Maria L.; Simoff, Ivailo et al.

Part of Pharmaceutics, 2020

• DOI for Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions
• Download full text (pdf) of Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions

Cell-type-resolved proteomic analysis of the human liver

Ölander, Magnus; Wiśniewski, Jacek R.; Artursson, Per

Part of Liver international, p. 1770-1780, 2020

• DOI for Cell-type-resolved proteomic analysis of the human liver
• Download full text (pdf) of Cell-type-resolved proteomic analysis of the human liver

Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Rendo, Verónica; Stoimenov, Ivaylo; Mateus, André; Sjöberg, Elin et al.

Part of Nature Communications, 2020

• DOI for Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy
• Download full text (pdf) of Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Global variability analysis of mRNA and protein concentrations across and within human tissues

Wegler, Christine; Ölander, Magnus; Wiśniewski, Jacek R; Lundquist, Patrik et al.

Part of NAR Genomics and Bioinformatics, 2020

• DOI for Global variability analysis of mRNA and protein concentrations across and within human tissues
• Download full text (pdf) of Global variability analysis of mRNA and protein concentrations across and within human tissues

The Critical Role of Passive Permeability in Designing Successful Drugs

Di, Li; Artursson, Per; Avdeef, Alex; Benet, Leslie Z. et al.

Part of ChemMedChem, p. 1862-1874, 2020

• DOI for The Critical Role of Passive Permeability in Designing Successful Drugs

A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (f(u,cell))

Treyer, Andrea; Walday, Sandra; Boriss, Hinnerk; Matsson, Pär et al.

Part of Pharmaceutical research, 2019

• DOI for A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (f(u,cell))
• Download full text (pdf) of A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (f(u,cell))

A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes

Ölander, Magnus; Wiśniewski, Jacek R.; Flörkemeier, Inken; Handin, Niklas et al.

Part of Archives of Toxicology, p. 819-829, 2019

• DOI for A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes
• Download full text (pdf) of A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes

Comprehensive drug uptake transporter proteomics and metabolomic profiling of human liver

Nies, A. T.; Handin, Niklas; Schaeffeler, E.; Haag, M. et al.

Part of Naunyn-Schmiedeberg's Archives of Pharmacology, 2019

• DOI for Comprehensive drug uptake transporter proteomics and metabolomic profiling of human liver

Experimental approaches to understand intracellular based drug bioavailability

Artursson, Per

Part of Drug Metabolism and Pharmacokinetics, 2019

• DOI for Experimental approaches to understand intracellular based drug bioavailability

Image-based quantification of cell debris as a measure of apoptosis

Ölander, Magnus; Handin, Niklas; Artursson, Per

Part of Analytical Chemistry, p. 5548-5552, 2019

• DOI for Image-based quantification of cell debris as a measure of apoptosis
• Download full text (pdf) of Image-based quantification of cell debris as a measure of apoptosis

Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies

Treyer, Andrea; Ullah, Mohammed; Parrott, Neil; Molitor, Birgit et al.

Part of AAPS Journal, 2019

• DOI for Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies
• Download full text (pdf) of Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies

Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations

Filppula, Anne M.; Parvizi, Rezvan; Mateus, André; Baranczewski, Pawel et al.

Part of Scientific Reports, 2019

• DOI for Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations
• Download full text (pdf) of Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations

Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking

Wisniewski, Jacek R.; Wegler, Christine; Artursson, Per

Part of Journal of Proteome Research, p. 217-224, 2019

• DOI for Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking
• Download full text (pdf) of Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking

Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

Prasad, Bhagwat; Achour, Brahim; Artursson, Per; Hop, Cornelis E. C. A. et al.

Part of Clinical Pharmacology and Therapeutics, p. 525-543, 2019

• DOI for Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound

Islam, Md. Koushikul; Strand, Mårten; Saleeb, Michael; Svensson, Richard et al.

Part of Scientific Reports, 2018

• DOI for Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound
• Download full text (pdf) of Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound

CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box

Karlgren, Maria; Simoff, Ivailo; Keiser, M.; Oswald, S. et al.

Part of Drug Metabolism And Disposition, p. 1776-1786, 2018

• DOI for CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box