Läkemedelsformulering

Digoxin Pharmacokinetics in Patients with Obesity Before and After a Gastric Bypass or a Strict Diet Compared with Normal Weight Individuals

Kvitne, Kine Eide; Hovd, Markus; Johnson, Line Kristin; Wegler, Christine et al.

Ingår i Clinical Pharmacokinetics, s. 109-120, 2024

• DOI för Digoxin Pharmacokinetics in Patients with Obesity Before and After a Gastric Bypass or a Strict Diet Compared with Normal Weight Individuals
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Expression of intestinal drug transporter proteins and metabolic enzymes in neonatal and pediatric patients

de Waal, Tom; Handin, Niklas; Brouwers, Joachim; Miserez, Marc et al.

Ingår i International Journal of Pharmaceutics, 2024

• DOI för Expression of intestinal drug transporter proteins and metabolic enzymes in neonatal and pediatric patients

Global ¹³C tracing and metabolic flux analysis of intact human liver tissue ex vivo

Grankvist, Nina; Jönsson, Cecilia; Hedin, Karin; Sundqvist, Nicolas et al.

Ingår i Nature Metabolism, 2024

• DOI för Global ¹³C tracing and metabolic flux analysis of intact human liver tissue ex vivo
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Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates

Yee, Sook Wah; Ferrández-Peral, Luis; Alentorn-Moron, Pol; Fontsere, Claudia et al.

Ingår i Nature Communications, 2024

• DOI för Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates
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In silico and biological analyses of missense variants of the human biliary efflux transporter ABCC2: effects of novel rare missense variants

Kölz, Charlotte; Gaugaz, Fabienne Z.; Handin, Niklas; Schaeffeler, Elke et al.

Ingår i British Journal of Pharmacology, 2024

• DOI för In silico and biological analyses of missense variants of the human biliary efflux transporter ABCC2: effects of novel rare missense variants

OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids

Mickols, Evgeniya; Meyer, Alina; Handin, Niklas; Stüwe, Malin et al.

Ingår i Scientific Reports, 2024

• DOI för OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids
• Ladda ner fulltext (pdf) av OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids

The choice of ultra-low attachment plates impacts primary human and primary canine hepatocyte spheroid formation, phenotypes, and function

Xing, Chen; Kemas, Aurino; Mickols, Evgeniya; Klein, Kathrin et al.

Ingår i Biotechnology Journal, 2024

• DOI för The choice of ultra-low attachment plates impacts primary human and primary canine hepatocyte spheroid formation, phenotypes, and function
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Epithelial and microbial determinants of colonic drug distribution

Hammar, Rebekkah; Sellin, Mikael E.; Artursson, Per

Ingår i European Journal of Pharmaceutical Sciences, 2023

• DOI för Epithelial and microbial determinants of colonic drug distribution
• Ladda ner fulltext (pdf) av Epithelial and microbial determinants of colonic drug distribution

Neither Gastric Bypass Surgery Nor Diet-Induced Weight-Loss Affect OATP1B1 Activity as Measured by Rosuvastatin Oral Clearance

Hovd, Markus; Robertsen, Ida; Johnson, Line Kristin; Krogstad, Veronica et al.

Ingår i Clinical Pharmacokinetics, s. 725-735, 2023

• DOI för Neither Gastric Bypass Surgery Nor Diet-Induced Weight-Loss Affect OATP1B1 Activity as Measured by Rosuvastatin Oral Clearance
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Proteome deconvolution of liver biopsies reveals hepatic cell composition as an important marker of fibrosis

Handin, Niklas; Yuan, Di; Olander, Magnus; Wegler, Christine et al.

Ingår i Computational and Structural Biotechnology Journal, s. 4361-4369, 2023

• DOI för Proteome deconvolution of liver biopsies reveals hepatic cell composition as an important marker of fibrosis
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Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat

Lundquist, Patrik; Khodus, Georgiy; Niu, Zhigao; Thwala, Lungile Nomcebo et al.

Ingår i ACS Nano, s. 14210-14229, 2022

• DOI för Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat
• Ladda ner fulltext 1 (pdf) av Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat
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Correlations between 4 beta-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range

Kvitne, Kine Eide; Hole, Kristine; Krogstad, Veronica; Wollmann, Birgit Malene et al.

Ingår i European Journal of Clinical Pharmacology, s. 1289-1299, 2022

• DOI för Correlations between 4 beta-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range
• Ladda ner fulltext (pdf) av Correlations between 4 beta-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range

Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity

Wegler, Christine; Wiśniewski, Jacek R; Robertsen, Ida; Christensen, Hege et al.

Ingår i Clinical Pharmacology and Therapeutics, s. 1142-1154, 2022

• DOI för Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity
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Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation

Tremmel, Roman; Nies, Anne T.; van Eijck, Barbara A. C.; Handin, Niklas et al.

Ingår i International Journal of Molecular Sciences, 2022

• DOI för Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation
• Ladda ner fulltext (pdf) av Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation

High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3

Chen, Eugene C.; Matsson, Pär; Azimi, Mina; Zhou, Xujia et al.

Ingår i Pharmaceutical research, s. 1599-1613, 2022

• DOI för High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3
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Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity

Kvitne, Kine Eide; Asberg, Anders; Johnson, Line K.; Wegler, Christine et al.

Ingår i Clinical and Translational Science, s. 2685-2696, 2022

• DOI för Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity
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Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration

Hellinen, Laura; Koskela, Ali; Vattulainen, Elina; Liukkonen, Mikko et al.

Ingår i Biomedicine and Pharmacotherapy, 2022

• DOI för Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration
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Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ

Al-Amin, Rasel A.; Johansson, Lars; Abdurakhmanov, Eldar; Landegren, Nils et al.

Ingår i Nucleic Acids Research, 2022

• DOI för Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ
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Professor Margareta Hammarlund-Udenaes - Humbled Scientist Shaping Modern Neuropharmacokinetics

Loryan, Irena; Smith, David E.; Artursson, Per; Breimer, Douwe et al.

Ingår i Pharmaceutical research, s. 1283-1289, 2022

• DOI för Professor Margareta Hammarlund-Udenaes - Humbled Scientist Shaping Modern Neuropharmacokinetics

Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity

Kvitne, Kine Eide; Krogstad, Veronica; Wegler, Christine; Johnson, Line Kristin et al.

Ingår i British Journal of Clinical Pharmacology, s. 4121-4133, 2022

• DOI för Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity
• Ladda ner fulltext (pdf) av Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity

Short- and long-term effects of body weight loss following calorie restriction and gastric bypass on CYP3A-activity: a non-randomized three-armed controlled trial

Kvitne, Kine Eide; Robertsen, Ida; Skovlund, Eva; Christensen, Hege et al.

Ingår i Clinical and Translational Science, s. 221-233, 2022

• DOI för Short- and long-term effects of body weight loss following calorie restriction and gastric bypass on CYP3A-activity: a non-randomized three-armed controlled trial
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The impact of inflammation on the expression of drug transporters and metabolic enzymes in colonic tissue from ulcerative colitis patients

de Waal, Tom; Handin, Niklas; Brouwers, Joachim; Ferrante, Marc et al.

Ingår i International Journal of Pharmaceutics, 2022

• DOI för The impact of inflammation on the expression of drug transporters and metabolic enzymes in colonic tissue from ulcerative colitis patients

Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis

Kundu, Snehangshu; Ali, Muhammad Akhtar; Handin, Niklas; Conway, Louis P. et al.

Ingår i Journal of Experimental & Clinical Cancer Research, 2021

• DOI för Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis
• Ladda ner fulltext (pdf) av Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis

Conditions for maintenance of hepatocyte differentiation and function in 3D cultures

Handin, Niklas; Mickols, Evgeniya; Ölander, Magnus; Rudfeldt, Jakob et al.

Ingår i iScience, 2021

• DOI för Conditions for maintenance of hepatocyte differentiation and function in 3D cultures
• Ladda ner fulltext (pdf) av Conditions for maintenance of hepatocyte differentiation and function in 3D cultures

Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network

Vinarov, Zahari; Abrahamsson, Bertil; Artursson, Per; Batchelor, Hannah et al.

Ingår i Advanced Drug Delivery Reviews, s. 289-331, 2021

• DOI för Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network
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Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1

Wegler, Christine; Gazit, Meryem; Issa, Karolina; Subramaniam, Sujay et al.

Ingår i Journal of Pharmaceutical Sciences, s. 388-396, 2021

• DOI för Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1
• Ladda ner fulltext (pdf) av Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1

Getting a grip with kirigami

Teleki, Alexandra; Artursson, Per

Ingår i Nature Materials, s. 1043-1044, 2021

• DOI för Getting a grip with kirigami

Hepatocyte size fractionation allows dissection of human liver zonation

Ölander, Magnus; Wegler, Christine; Flörkemeier, Inken; Treyer, Andrea et al.

Ingår i Journal of Cellular Physiology, s. 5885-5894, 2021

• DOI för Hepatocyte size fractionation allows dissection of human liver zonation
• Ladda ner fulltext (pdf) av Hepatocyte size fractionation allows dissection of human liver zonation

Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes

Wegler, Christine; Matsson, Pär; Krogstad, Veronica; Urdzik, Jozef et al.

Ingår i Molecular Pharmaceutics, s. 1792-1805, 2021

• DOI för Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes
• Ladda ner fulltext (pdf) av Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes

Newly developed dual topoisomerase inhibitor P8-D6 is highly active in ovarian cancer

Flörkemeier, Inken; Steinhauer, Tamara N.; Hedemann, Nina; Ölander, Magnus et al.

Ingår i THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2021

• DOI för Newly developed dual topoisomerase inhibitor P8-D6 is highly active in ovarian cancer
• Ladda ner fulltext (pdf) av Newly developed dual topoisomerase inhibitor P8-D6 is highly active in ovarian cancer

Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease

Asad, Shno; Wegler, Christine; Ahl, David; Bergström, Christel A. S. et al.

Ingår i Journal of Pharmaceutical Sciences, s. 239-250, 2021

• DOI för Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease
• Ladda ner fulltext (pdf) av Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease

Proteomics‐Informed Prediction of Rosuvastatin Plasma Profiles in Patients with a Wide Range of Body Weight

Wegler, Christine; Prieto Garcia, Luna; Klinting, Signe; Robertsen, Ida et al.

Ingår i Clinical Pharmacology and Therapeutics, s. 762-771, 2021

• DOI för Proteomics‐Informed Prediction of Rosuvastatin Plasma Profiles in Patients with a Wide Range of Body Weight
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A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity

Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K. et al.

Ingår i Drug Metabolism And Disposition, s. 8-17, 2020

• DOI för A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity

A new opening for orally taken peptide drugs

Artursson, Per; Lundquist, Patrik

Ingår i Nature Biomedical Engineering, s. 12-13, 2020

• DOI för A new opening for orally taken peptide drugs

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions

Antonescu, Irina E.; Karlgren, Maria; Pedersen, Maria L.; Simoff, Ivailo et al.

Ingår i Pharmaceutics, 2020

• DOI för Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions
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Cell-type-resolved proteomic analysis of the human liver

Ölander, Magnus; Wiśniewski, Jacek R.; Artursson, Per

Ingår i Liver international, s. 1770-1780, 2020

• DOI för Cell-type-resolved proteomic analysis of the human liver
• Ladda ner fulltext (pdf) av Cell-type-resolved proteomic analysis of the human liver

Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Rendo, Verónica; Stoimenov, Ivaylo; Mateus, André; Sjöberg, Elin et al.

Ingår i Nature Communications, 2020

• DOI för Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy
• Ladda ner fulltext (pdf) av Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Global variability analysis of mRNA and protein concentrations across and within human tissues

Wegler, Christine; Ölander, Magnus; Wiśniewski, Jacek R; Lundquist, Patrik et al.

Ingår i NAR Genomics and Bioinformatics, 2020

• DOI för Global variability analysis of mRNA and protein concentrations across and within human tissues
• Ladda ner fulltext (pdf) av Global variability analysis of mRNA and protein concentrations across and within human tissues

The Critical Role of Passive Permeability in Designing Successful Drugs

Di, Li; Artursson, Per; Avdeef, Alex; Benet, Leslie Z. et al.

Ingår i ChemMedChem, s. 1862-1874, 2020

• DOI för The Critical Role of Passive Permeability in Designing Successful Drugs

A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (f(u,cell))

Treyer, Andrea; Walday, Sandra; Boriss, Hinnerk; Matsson, Pär et al.

Ingår i Pharmaceutical research, 2019

• DOI för A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (f(u,cell))
• Ladda ner fulltext (pdf) av A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (f(u,cell))

A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes

Ölander, Magnus; Wiśniewski, Jacek R.; Flörkemeier, Inken; Handin, Niklas et al.

Ingår i Archives of Toxicology, s. 819-829, 2019

• DOI för A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes
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Comprehensive drug uptake transporter proteomics and metabolomic profiling of human liver

Nies, A. T.; Handin, Niklas; Schaeffeler, E.; Haag, M. et al.

Ingår i Naunyn-Schmiedeberg's Archives of Pharmacology, 2019

• DOI för Comprehensive drug uptake transporter proteomics and metabolomic profiling of human liver

Experimental approaches to understand intracellular based drug bioavailability

Artursson, Per

Ingår i Drug Metabolism and Pharmacokinetics, 2019

• DOI för Experimental approaches to understand intracellular based drug bioavailability

Image-based quantification of cell debris as a measure of apoptosis

Ölander, Magnus; Handin, Niklas; Artursson, Per

Ingår i Analytical Chemistry, s. 5548-5552, 2019

• DOI för Image-based quantification of cell debris as a measure of apoptosis
• Ladda ner fulltext (pdf) av Image-based quantification of cell debris as a measure of apoptosis

Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies

Treyer, Andrea; Ullah, Mohammed; Parrott, Neil; Molitor, Birgit et al.

Ingår i AAPS Journal, 2019

• DOI för Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies
• Ladda ner fulltext (pdf) av Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies

Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations

Filppula, Anne M.; Parvizi, Rezvan; Mateus, André; Baranczewski, Pawel et al.

Ingår i Scientific Reports, 2019

• DOI för Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations
• Ladda ner fulltext (pdf) av Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations

Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking

Wisniewski, Jacek R.; Wegler, Christine; Artursson, Per

Ingår i Journal of Proteome Research, s. 217-224, 2019

• DOI för Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking
• Ladda ner fulltext (pdf) av Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking

Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

Prasad, Bhagwat; Achour, Brahim; Artursson, Per; Hop, Cornelis E. C. A. et al.

Ingår i Clinical Pharmacology and Therapeutics, s. 525-543, 2019

• DOI för Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound

Islam, Md. Koushikul; Strand, Mårten; Saleeb, Michael; Svensson, Richard et al.

Ingår i Scientific Reports, 2018

• DOI för Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound
• Ladda ner fulltext (pdf) av Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound

CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box

Karlgren, Maria; Simoff, Ivailo; Keiser, M.; Oswald, S. et al.

Ingår i Drug Metabolism And Disposition, s. 1776-1786, 2018

• DOI för CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box