Our publications

Weight-band-based simplification of oral allometric miltefosine dosing in paediatric patients with visceral leishmaniasis-right-to-reply

Mazariegos Herrera, Andres; Karlsson, Mats O.; Svensson, Elin M.; Dorlo, Thomas P. C.

Part of Journal of Antimicrobial Chemotherapy, 2026

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• DOI for Weight-band-based simplification of oral allometric miltefosine dosing in paediatric patients with visceral leishmaniasis-right-to-reply

Using Stochastic Simulation-Estimation and Automated Model Development to Assess Power and Accuracy for Covariate Identification

Hsu, Ya-Han; Costa, Bárbara; Vale, Nuno; Dorlo, Thomas P. C. et al.

Part of CPT, 2026

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• DOI for Using Stochastic Simulation-Estimation and Automated Model Development to Assess Power and Accuracy for Covariate Identification
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A pilot study evaluating the tolerability and effectiveness of miltefosine and sodium stibogluconate for the treatment of cutaneous leishmaniasis in Kandahar, Afghanistan

Rahimi, Bilal Ahmad; Disphanurat, Wareeporn; Bakhtialy, Khoshal; Lali, Wais Mohammad et al.

Part of Tropical Medicine and Health, 2026

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• DOI for A pilot study evaluating the tolerability and effectiveness of miltefosine and sodium stibogluconate for the treatment of cutaneous leishmaniasis in Kandahar, Afghanistan
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Translational Pharmacokinetic-Pharmacodynamic Modeling and Efficacious Human Dose Prediction of DNDI-6148 for the Treatment of Cutaneous Leishmaniasis

Henninger, Rasmus Hansen; Schouten, Wietse M.; Arana, Byron; Gillon, Jean-Yves et al.

Part of Clinical and Translational Science, 2026

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• DOI for Translational Pharmacokinetic-Pharmacodynamic Modeling and Efficacious Human Dose Prediction of DNDI-6148 for the Treatment of Cutaneous Leishmaniasis
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Bidirectional Interaction Between Liposomal Amphotericin B Pharmacokinetics and Parasite Dynamics in Patients With Post-Kala-Azar Dermal Leishmaniasis: Potential Implications for Optimal Dosing

Chu, Wan-Yu; Singh, Om Prakash; Sundar, Shyam; Mondal, Dinesh et al.

Part of Clinical Pharmacology and Therapeutics, p. 437-446, 2026

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• DOI for Bidirectional Interaction Between Liposomal Amphotericin B Pharmacokinetics and Parasite Dynamics in Patients With Post-Kala-Azar Dermal Leishmaniasis: Potential Implications for Optimal Dosing
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Weight-band-based simplification of oral allometric miltefosine dosing in paediatric patients with visceral leishmaniasis

Mazariegos Herrera, Andres; Karlsson, Mats O.; Svensson, Elin M.; Dorlo, Thomas P. C.

Part of Journal of Antimicrobial Chemotherapy, 2026

Article in journal

• DOI for Weight-band-based simplification of oral allometric miltefosine dosing in paediatric patients with visceral leishmaniasis
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Skin pharmacokinetics and pharmacodynamics in patients with post-kala-azar dermal leishmaniasis

Chu, Wan-Yu; Singh, Om Prakash; Sundar, Shyam; Pandey, Krishna et al.

Part of International Journal of Antimicrobial Agents, 2026

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• DOI for Skin pharmacokinetics and pharmacodynamics in patients with post-kala-azar dermal leishmaniasis
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Pharmacokinetics and Pharmacodynamics of Fosravuconazole, Itraconazole and Hydroxyitraconazole in Sudanese Patients With Eumycetoma

Chu, Wan-Yu; Fahal, Ahmed H; Ahmed, Eiman Siddig; Bakhiet, Sahar Mubarak et al.

Part of Journal of Infectious Diseases, 2025

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• DOI for Pharmacokinetics and Pharmacodynamics of Fosravuconazole, Itraconazole and Hydroxyitraconazole in Sudanese Patients With Eumycetoma
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Importance of Lysosomal Trapping and Plasmodium Parasite Infection on the Pharmacokinetics of Pyronaridine: A Physiologically Based Pharmacokinetic Model-Based Study

Chu, Wan-Yu; Schouten, Wietse M.; Mavoko, Hypolite Muhindo; Tshiongo, Japhet Kabalu et al.

Part of Clinical Pharmacokinetics, p. 1855-1867, 2025

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• DOI for Importance of Lysosomal Trapping and Plasmodium Parasite Infection on the Pharmacokinetics of Pyronaridine: A Physiologically Based Pharmacokinetic Model-Based Study
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Validated LC-MS/MS Method for Quantifying the Antiparasitic Nitroimidazole DNDI-0690 in Preclinical Target Site PK/PD Studies

Schouten, Wietse M.; van Bocxlaer, Katrien; Rosing, Hilde; Huitema, Alwin D. R. et al.

Part of Biomedical Chromatography, 2025

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• DOI for Validated LC-MS/MS Method for Quantifying the Antiparasitic Nitroimidazole DNDI-0690 in Preclinical Target Site PK/PD Studies
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Pharmacokinetic Model-Informed Precision Dosing of Natalizumab in Multiple Sclerosis

van den Berg, Stefan P. H.; Toorop, Alyssa A.; Hooijberg, Femke; Wolbink, Gertjan et al.

Part of CPT, p. 1032-1041, 2025

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• DOI for Pharmacokinetic Model-Informed Precision Dosing of Natalizumab in Multiple Sclerosis
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Quantitative analysis of DNDI-6174 using UPLC-MS/MS: A preclinical target site pharmacokinetic study

Schouten, Wietse M.; Van Bocxlaer, Katrien; Rosing, Hilde; Huitema, Alwin D. R. et al.

Part of Journal of chromatography. B, 2025

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• DOI for Quantitative analysis of DNDI-6174 using UPLC-MS/MS: A preclinical target site pharmacokinetic study
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Does one model fit all mAbs?: An evaluation of population pharmacokinetic models

van den Berg, Stefan P. H.; Adolfsen, Philine E. A.; Dorlo, Thomas P. C.; Rispens, Theo

Part of mAbs, 2025

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• DOI for Does one model fit all mAbs?: An evaluation of population pharmacokinetic models
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Skin pharmacokinetics of miltefosine in the treatment of post-kala-azar dermal leishmaniasis in South Asia: authors' response

Dorlo, Thomas P. C.; Chu, Wan-Yu

Part of Journal of Antimicrobial Chemotherapy, p. 1162-1164, 2025

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• DOI for Skin pharmacokinetics of miltefosine in the treatment of post-kala-azar dermal leishmaniasis in South Asia: authors' response

Precision Dosing of Intravenous Tocilizumab: Development of Pharmacokinetic Model–Derived Tapering Strategies for Patients With Rheumatoid Arthritis

Hooijberg, Femke; van den Berg, Stefan P. H.; Layegh, Zohra; Leeuw, Maureen et al.

Part of Therapeutic Drug Monitoring, p. 337-345, 2025

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• DOI for Precision Dosing of Intravenous Tocilizumab: Development of Pharmacokinetic Model–Derived Tapering Strategies for Patients With Rheumatoid Arthritis

Development and validation of ultra-performance liquid chromatography tandem mass spectrometry methods for the quantitative analysis of the antiparasitic drug DNDI-6148 in human plasma and various mouse biomatrices

Schouten, Wietse M; Van Bocxlaer, Katrien; Rosing, Hilde; Huitema, Alwin D R et al.

Part of Journal of chromatography. B, 2025

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• DOI for Development and validation of ultra-performance liquid chromatography tandem mass spectrometry methods for the quantitative analysis of the antiparasitic drug DNDI-6148 in human plasma and various mouse biomatrices
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Development and validation of an ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of the antimalarial drug pyronaridine in human whole blood

Schouten, Wietse M.; Roseboom, Ignace C.; Lucas, Luc; Tshiongo, Japhet Kabalu et al.

Part of Journal of Pharmaceutical and Biomedical Analysis, 2024

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• DOI for Development and validation of an ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of the antimalarial drug pyronaridine in human whole blood
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Determining tissue distribution of the oral antileishmanial agent miltefosine: a physiologically-based pharmacokinetic modeling approach

Ramisetty, Bhargavi Srija; Yang, Sihyung; Dorlo, Thomas P.C.; Wang, Michael Zhuo

Part of Antimicrobial Agents and Chemotherapy, 2024

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• DOI for Determining tissue distribution of the oral antileishmanial agent miltefosine: a physiologically-based pharmacokinetic modeling approach

Predictability of human exposure by human-CYP3A4-transgenic mouse models: A meta-analysis

Damoiseaux, David; Schinkel, Alfred H.; Beijnen, Jos H.; Huitema, Alwin D. R. et al.

Part of Clinical and Translational Science, 2024

Article, review/survey

• DOI for Predictability of human exposure by human-CYP3A4-transgenic mouse models: A meta-analysis
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Early Prediction and Impact Assessment of CYP3A4-Related Drug-Drug Interactions for Small-Molecule Anticancer Drugs Using Human-CYP3A4-Transgenic Mouse Models

Damoiseaux, David; Beijnen, Jos H.; Huitema, Alwin D. R.; Dorlo, Thomas P. C.

Part of Drug Metabolism And Disposition, p. 1217-1223, 2024

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• DOI for Early Prediction and Impact Assessment of CYP3A4-Related Drug-Drug Interactions for Small-Molecule Anticancer Drugs Using Human-CYP3A4-Transgenic Mouse Models
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Skin pharmacokinetics of miltefosine in the treatment of post-kala-azar dermal leishmaniasis in South Asia

Palic, Semra; Chu, Wan-Yu; Sundar, Shyam; Mondal, Dinesh et al.

Part of Journal of Antimicrobial Chemotherapy, p. 1547-1554, 2024

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• DOI for Skin pharmacokinetics of miltefosine in the treatment of post-kala-azar dermal leishmaniasis in South Asia
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Tocilizumab Dose Tapering Based on a Model-Based Algorithm is Feasible in Clinical Practice: A Short Communication

Hooijberg, Femke; Layegh, Zohra; Leeuw, Maureen; Boekel, Laura et al.

Part of Therapeutic Drug Monitoring, p. 410-414, 2024

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• DOI for Tocilizumab Dose Tapering Based on a Model-Based Algorithm is Feasible in Clinical Practice: A Short Communication

Disease-Specific Differences in Pharmacokinetics of Paromomycin and Miltefosine Between Post-Kala-Azar Dermal Leishmaniasis and Visceral Leishmaniasis Patients in Eastern Africa

Chu, Wan-Yu; Verrest, Luka; Younis, Brima M; Musa, Ahmed M et al.

Part of Journal of Infectious Diseases, 2024

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• DOI for Disease-Specific Differences in Pharmacokinetics of Paromomycin and Miltefosine Between Post-Kala-Azar Dermal Leishmaniasis and Visceral Leishmaniasis Patients in Eastern Africa
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Two dose levels of once-weekly fosravuconazole versus daily itraconazole in combination with surgery in patients with eumycetoma in Sudan: a randomised, double-blind, phase 2, proof-of-concept superiority trial

Fahal, Ahmed H.; Ahmed, Eiman Siddig; Bakhiet, Sahar Mubarak; Bakhiet, Osama Elhadi et al.

Part of The Lancet - Infectious diseases, p. 1254-1265, 2024

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• DOI for Two dose levels of once-weekly fosravuconazole versus daily itraconazole in combination with surgery in patients with eumycetoma in Sudan: a randomised, double-blind, phase 2, proof-of-concept superiority trial

Population Pharmacokinetics and Target Attainment of Allopurinol and Oxypurinol Before, During, and After Cardiac Surgery with Cardiopulmonary Bypass in Neonates with Critical Congenital Heart Disease

Chu, Wan-Yu; Nijman, Maaike; Stegeman, Raymond; Breur, Johannes M. P. J. et al.

Part of Clinical Pharmacokinetics, p. 1205-1220, 2024

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• DOI for Population Pharmacokinetics and Target Attainment of Allopurinol and Oxypurinol Before, During, and After Cardiac Surgery with Cardiopulmonary Bypass in Neonates with Critical Congenital Heart Disease
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Power to identify exposure-response relationships in phase IIa pulmonary tuberculosis trials with multi-dimensional bacterial load modeling

Koele, Simon E; Dorlo, Thomas P. C.; Upton, Caryn M; Aarnoutse, Rob E et al.

Part of CPT, p. 374-385, 2024

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• DOI for Power to identify exposure-response relationships in phase IIa pulmonary tuberculosis trials with multi-dimensional bacterial load modeling
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Leishmania blood parasite dynamics during and after treatment of visceral leishmaniasis in Eastern Africa: A pharmacokinetic-pharmacodynamic model

Verrest, Luka; Monnerat, Severine; Musa, Ahmed M.; Mbui, Jane et al.

Part of PLoS Neglected Tropical Diseases, 2024

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• DOI for Leishmania blood parasite dynamics during and after treatment of visceral leishmaniasis in Eastern Africa: A pharmacokinetic-pharmacodynamic model
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The status of combination therapy for visceral leishmaniasis: an updated review

van Griensven, Johan; Dorlo, Thomas P. C.; Diro, Ermias; Costa, Carlos et al.

Part of The Lancet - Infectious diseases, 2024

Article, review/survey

• DOI for The status of combination therapy for visceral leishmaniasis: an updated review

Semi-physiological Enriched Population Pharmacokinetic Modelling to Predict the Effects of Pregnancy on the Pharmacokinetics of Cytotoxic Drugs

Janssen, J. M.; Damoiseaux, D.; van Hasselt, J. G. C.; Amant, F. C. H. et al.

Part of Clinical Pharmacokinetics, p. 1157-1167, 2023

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• DOI for Semi-physiological Enriched Population Pharmacokinetic Modelling to Predict the Effects of Pregnancy on the Pharmacokinetics of Cytotoxic Drugs
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Bioanalytical methods for pharmacokinetic studies of antileishmanial drugs

Roseboom, Ignace C; Rosing, Hilde; Beijnen, Jos H; Dorlo, Thomas P. C.

Part of Biomedical Chromatography, 2023

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• DOI for Bioanalytical methods for pharmacokinetic studies of antileishmanial drugs
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A physiologically based pharmacokinetic model for [Ga-68]Ga-(HA-)DOTATATE to predict whole-body distribution and tumor sink effects in GEP-NET patients

Siebinga, Hinke; de Wit-van der Veen, Berlinda J. J.; Beijnen, Jos H.; Dorlo, Thomas P. C. et al.

Part of EJNMMI Research, 2023

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• DOI for A physiologically based pharmacokinetic model for [Ga-68]Ga-(HA-)DOTATATE to predict whole-body distribution and tumor sink effects in GEP-NET patients
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Efficacy and safety of pyronaridine-artesunate (PYRAMAX) for the treatment of P. falciparum uncomplicated malaria in African pregnant women (PYRAPREG): study protocol for a phase 3, non-inferiority, randomised open-label clinical trial

Djimde, Moussa; Tshiongo, Japhet Kabalu; Muhindo, Hypolite Mavoko; Tinto, Halidou et al.

Part of BMJ Open, 2023

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• DOI for Efficacy and safety of pyronaridine-artesunate (PYRAMAX) for the treatment of P. falciparum uncomplicated malaria in African pregnant women (PYRAPREG): study protocol for a phase 3, non-inferiority, randomised open-label clinical trial
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Optimizing carboplatin dosing by an improved prediction of carboplatin clearance using a CT‐enhanced estimate of renal function

Molenaar‐Kuijsten, Laura; Pieters, Tobias T.; Veldhuis, Wouter B.; Moeskops, Pim et al.

Part of British Journal of Clinical Pharmacology, p. 3016-3025, 2023

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• DOI for Optimizing carboplatin dosing by an improved prediction of carboplatin clearance using a CT‐enhanced estimate of renal function

Development of a Therapeutic Drug Monitoring Strategy for the Optimization of Vincristine Treatment in Pediatric Oncology Populations in Africa

Van der Heijden, Lisa T.; Nijstad, A. Laura; Uittenboogaard, Aniek; Beijnen, Jos H. et al.

Part of Therapeutic Drug Monitoring, p. 354-363, 2023

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• DOI for Development of a Therapeutic Drug Monitoring Strategy for the Optimization of Vincristine Treatment in Pediatric Oncology Populations in Africa

High accumulation of nivolumab in human breast milk: A case report

de Jong, Karen; Damoiseaux, David; Pluim, Dick; Rosing, Hilde et al.

Part of Biomedicine and Pharmacotherapy, 2023

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• DOI for High accumulation of nivolumab in human breast milk: A case report
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Pyronaridine: a review of its clinical pharmacology in the treatment of malaria

Chu, Wan-Yu; Dorlo, Thomas P. C.

Part of Journal of Antimicrobial Chemotherapy, p. 2406-2418, 2023

Article, review/survey

• DOI for Pyronaridine: a review of its clinical pharmacology in the treatment of malaria
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A naïve pooled data approach for extrapolation of Phase 0 microdose trials to therapeutic dosing regimens

van der Heijden, Lisa; van Nuland, Merel; Beijnen, Jos; Huitema, Alwin et al.

Part of Clinical and Translational Science, p. 258-268, 2023

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• DOI for A naïve pooled data approach for extrapolation of Phase 0 microdose trials to therapeutic dosing regimens

Physiologically‐based pharmacokinetic model to predict doxorubicin and paclitaxel exposure in infants through breast milk

Damoiseaux, David; Amant, Frédéric; Beijnen, Jos H.; Barnett, Shelby et al.

Part of CPT, p. 1931-1944, 2023

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• DOI for Physiologically‐based pharmacokinetic model to predict doxorubicin and paclitaxel exposure in infants through breast milk
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The use of microtracers in food-effect trials: An alternative study design for toxic drugs with long half-lives exemplified by the case for alectinib

van Der Heijden, L. T.; Steeghs, N.; Beijnen, J. H.; Huitema, A. D. R. et al.

Part of Clinical and Translational Science, p. 2557-2564, 2023

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• DOI for The use of microtracers in food-effect trials: An alternative study design for toxic drugs with long half-lives exemplified by the case for alectinib
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Population pharmacokinetic dosimetry model using imaging data to assess variability in pharmacokinetics of ¹⁷⁷Lu-PSMA-617 in prostate cancer patients

Siebinga, Hinke; Privé, Bastiaan M.; Peters, Steffie M. B.; Nagarajah, James et al.

Part of CPT, p. 1060-1071, 2023

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• DOI for Population pharmacokinetic dosimetry model using imaging data to assess variability in pharmacokinetics of ¹⁷⁷Lu-PSMA-617 in prostate cancer patients
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Population pharmacokinetics of a combination of miltefosine and paromomycin in Eastern African children and adults with visceral leishmaniasis

Verrest, Luka; Roseboom, Ignace C.; Wasunna, Monique; Mbui, Jane et al.

Part of Journal of Antimicrobial Chemotherapy, p. 2702-2714, 2023

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• DOI for Population pharmacokinetics of a combination of miltefosine and paromomycin in Eastern African children and adults with visceral leishmaniasis
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Safety and efficacy of paromomycin/miltefosine/liposomal amphotericin B combinations for the treatment of post-kala-azar dermal leishmaniasis in Sudan: A phase II, open label, randomized, parallel arm study

Younis, Brima Musa; Mudawi Musa, Ahmed; Monnerat, Severine; Saeed, Mohammed Abdelrahim et al.

Part of PLoS Neglected Tropical Diseases, 2023

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• DOI for Safety and efficacy of paromomycin/miltefosine/liposomal amphotericin B combinations for the treatment of post-kala-azar dermal leishmaniasis in Sudan: A phase II, open label, randomized, parallel arm study
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Predicting [¹⁷⁷Lu]Lu-HA-DOTATATE kidney and tumor accumulation based on [⁶⁸Ga]Ga-HA-DOTATATE diagnostic imaging using semi-physiological population pharmacokinetic modeling

Siebinga, Hinke; de van der Veen, Berlinda J.; Beijnen, Jos H.; Stokkel, Marcel P. M. et al.

Part of EJNMMI Physics, 2023

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• DOI for Predicting [¹⁷⁷Lu]Lu-HA-DOTATATE kidney and tumor accumulation based on [⁶⁸Ga]Ga-HA-DOTATATE diagnostic imaging using semi-physiological population pharmacokinetic modeling
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Comment on "Dosing implications for liposomal amphotericin B in pregnancy"

Chu, Wan-Yu; Dorlo, Thomas P. C.

Part of Pharmacotherapy, p. 991-991, 2023

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• DOI for Comment on "Dosing implications for liposomal amphotericin B in pregnancy"

Predicting Chemotherapy Distribution into Breast Milk for Breastfeeding Women Using a Population Pharmacokinetic Approach

Damoiseaux, David; Centanni, Daniel; Beijnen, Jos H.; Amant, Frédéric et al.

Part of Clinical Pharmacokinetics, p. 969-980, 2023

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• DOI for Predicting Chemotherapy Distribution into Breast Milk for Breastfeeding Women Using a Population Pharmacokinetic Approach
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Presence of Five Chemotherapeutic Drugs in Breast Milk as a Guide for the Safe Use of Chemotherapy During Breastfeeding: Results From a Case Series.

Damoiseaux, David; Calpe, Silvia; Rosing, Hilde; Beijnen, Jos H et al.

Part of Clinical Pharmacology and Therapeutics, p. 404-410, 2022

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• DOI for Presence of Five Chemotherapeutic Drugs in Breast Milk as a Guide for the Safe Use of Chemotherapy During Breastfeeding: Results From a Case Series.

Everolimus Concentration in Saliva to Predict Stomatitis: A Feasibility Study in Patients with Cancer.

Molenaar-Kuijsten, Laura; Verheijen, Remy B; Jacobs, Bart A W; Thijssen, Bas et al.

Part of Therapeutic Drug Monitoring, p. 520-526, 2022

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• DOI for Everolimus Concentration in Saliva to Predict Stomatitis: A Feasibility Study in Patients with Cancer.

Paromomycin and Miltefosine Combination as an Alternative to Treat Patients With Visceral Leishmaniasis in Eastern Africa: A Randomized, Controlled, Multicountry Trial.

Musa, Ahmed M; Mbui, Jane; Mohammed, Rezika; Olobo, Joseph et al.

Part of Clinical Infectious Diseases, 2022

Article in journal

• DOI for Paromomycin and Miltefosine Combination as an Alternative to Treat Patients With Visceral Leishmaniasis in Eastern Africa: A Randomized, Controlled, Multicountry Trial.

Semi-mechanistic Modeling of Hypoxanthine, Xanthine, and Uric Acid Metabolism in Asphyxiated Neonates

Chu, Wan-Yu; Allegaert, Karel; Dorlo, Thomas P. C.; Huitema, Alwin D R

Part of Clinical Pharmacokinetics, p. 1545-1558, 2022

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• DOI for Semi-mechanistic Modeling of Hypoxanthine, Xanthine, and Uric Acid Metabolism in Asphyxiated Neonates
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Editorial: Therapeutic Drug Monitoring (TDM)

Simeoli, Raffaele; Dorlo, Thomas P. C.; Hanff, Lidwien M; Huitema, Alwin D R et al.

Part of Frontiers in Pharmacology, p. 931843, 2022

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• DOI for Editorial: Therapeutic Drug Monitoring (TDM)
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Emerging talents in Frontiers in Pharmacology: Drug metabolism and transport 2022

Hinds, Terry D.; Valoti, Massimo; Lai, Yurong; Dorlo, Thomas P. C. et al.

Part of Frontiers in Pharmacology, 2022

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• DOI for Emerging talents in Frontiers in Pharmacology: Drug metabolism and transport 2022
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Population Pharmacokinetic Modelling to Support the Evaluation of Preclinical Pharmacokinetic Experiments with Lorlatinib

Damoiseaux, David; Li, Wenlong; Beijnen, Jos H; Schinkel, Alfred H et al.

Part of Journal of Pharmaceutical Sciences, p. 495-504, 2022

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• DOI for Population Pharmacokinetic Modelling to Support the Evaluation of Preclinical Pharmacokinetic Experiments with Lorlatinib

Longitudinal nonlinear mixed effects modeling of EGFR mutations in ctDNA as predictor of disease progression in treatment of EGFR-mutant non-small cell lung cancer.

Janssen, Julie M; Verheijen, Remy B; van Duijl, Tirsa T; Lin, Lishi et al.

Part of Clinical and Translational Science, p. 1916-1925, 2022

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• DOI for Longitudinal nonlinear mixed effects modeling of EGFR mutations in ctDNA as predictor of disease progression in treatment of EGFR-mutant non-small cell lung cancer.
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Pharmacokinetic/Pharmacodynamic Modelling of Allopurinol, its Active Metabolite Oxypurinol, and Biomarkers Hypoxanthine, Xanthine and Uric Acid in Hypoxic-Ischemic Encephalopathy Neonates

Chu, Wan-Yu; Annink, Kim V; Nijstad, A Laura; Maiwald, Christian A et al.

Part of Clinical Pharmacokinetics, p. 321-333, 2022

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• DOI for Pharmacokinetic/Pharmacodynamic Modelling of Allopurinol, its Active Metabolite Oxypurinol, and Biomarkers Hypoxanthine, Xanthine and Uric Acid in Hypoxic-Ischemic Encephalopathy Neonates

Development and validation of a high-performance liquid chromatography tandem mass spectrometry method for the quantification of the antiparasitic and antifungal drug amphotericin B in human skin tissue.

Roseboom, Ignace C; Thijssen, Bas; Rosing, Hilde; Alves, Fabiana et al.

Part of Journal of chromatography. B, 2022

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• DOI for Development and validation of a high-performance liquid chromatography tandem mass spectrometry method for the quantification of the antiparasitic and antifungal drug amphotericin B in human skin tissue.
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Development and validation of an HPLC-MS/MS method for the quantification of the anti-leishmanial drug miltefosine in human skin tissue.

Roseboom, Ignace C; Thijssen, Bas; Rosing, Hilde; Alves, Fabiana et al.

Part of Journal of Pharmaceutical and Biomedical Analysis, p. 114402, 2022

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• DOI for Development and validation of an HPLC-MS/MS method for the quantification of the anti-leishmanial drug miltefosine in human skin tissue.
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Development and validation of an ultra-high performance liquid chromatography coupled to tandem mass spectrometry method for the quantification of the antileishmanial drug paromomycin in human skin tissue.

Roseboom, Ignace C; Thijssen, Bas; Rosing, Hilde; Alves, Fabiana et al.

Part of Journal of chromatography. B, 2022

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• DOI for Development and validation of an ultra-high performance liquid chromatography coupled to tandem mass spectrometry method for the quantification of the antileishmanial drug paromomycin in human skin tissue.
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Development of a population pharmacokinetic/pharmacodynamic model for various oral paclitaxel formulations co-administered with ritonavir and thrombospondin-1 based on data from early phase clinical studies.

van Eijk, Maarten; Yu, Huixin; Sawicki, Emilia; de Weger, Vincent A et al.

Part of Cancer Chemotherapy and Pharmacology, p. 71-82, 2022

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• DOI for Development of a population pharmacokinetic/pharmacodynamic model for various oral paclitaxel formulations co-administered with ritonavir and thrombospondin-1 based on data from early phase clinical studies.
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An update on the clinical pharmacology of miltefosine in the treatment of leishmaniasis.

Palić, Semra; Beijnen, Jos H; Dorlo, Thomas P. C.

Part of International Journal of Antimicrobial Agents, p. 106459, 2022

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• DOI for An update on the clinical pharmacology of miltefosine in the treatment of leishmaniasis.

No evidence for cardiotoxicity of miltefosine

Dorlo, Thomas P. C.

Part of Anais Brasileiros de Dermatologia, p. 548-549, 2022

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• DOI for No evidence for cardiotoxicity of miltefosine
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Predictiveness of the Human-CYP3A4-Transgenic Mouse Model (Cyp3aXAV) for Human Drug Exposure of CYP3A4-Metabolized Drugs.

Damoiseaux, David; Li, Wenlong; Martínez-Chávez, Alejandra; Beijnen, Jos H et al.

Part of Pharmaceuticals (Basel, Switzerland), 2022

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• DOI for Predictiveness of the Human-CYP3A4-Transgenic Mouse Model (Cyp3aXAV) for Human Drug Exposure of CYP3A4-Metabolized Drugs.

Population Pharmacokinetics of Docetaxel, Paclitaxel, Doxorubicin and Epirubicin in Pregnant Women with Cancer: A Study from the International Network of Cancer, Infertility and Pregnancy (INCIP).

Janssen, Julie M; Van Calsteren, Kristel; Dorlo, Thomas P C; Halaska, Michael J et al.

Part of Clinical Pharmacokinetics, p. 775-784, 2021

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• DOI for Population Pharmacokinetics of Docetaxel, Paclitaxel, Doxorubicin and Epirubicin in Pregnant Women with Cancer: A Study from the International Network of Cancer, Infertility and Pregnancy (INCIP).

Worse capecitabine treatment outcome in patients with a low skeletal muscle mass is not explained by altered pharmacokinetics.

Molenaar-Kuijsten, Laura; Jacobs, Bart Albertus Wilhelmus; Kurk, Sophie Alberdine; May, Anne Maria et al.

Part of Cancer Medicine, p. 4781-4789, 2021

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• DOI for Worse capecitabine treatment outcome in patients with a low skeletal muscle mass is not explained by altered pharmacokinetics.

Population Pharmacokinetics of Intracellular 5-Fluorouridine 5'-Triphosphate and its Relationship with Hand-and-Foot Syndrome in Patients Treated with Capecitabine.

Janssen, Julie M; Jacobs, Bart A W; Roosendaal, Jeroen; Derissen, Ellen J B et al.

Part of AAPS Journal, p. 23, 2021

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• DOI for Population Pharmacokinetics of Intracellular 5-Fluorouridine 5'-Triphosphate and its Relationship with Hand-and-Foot Syndrome in Patients Treated with Capecitabine.

A physiologically based pharmacokinetic (PBPK) model to describe organ distribution of ⁶⁸Ga-DOTATATE in patients without neuroendocrine tumors

Siebinga, H; de Wit-van der Veen, B J; Beijnen, J H; Stokkel, M P M et al.

Part of EJNMMI Research, 2021

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• DOI for A physiologically based pharmacokinetic (PBPK) model to describe organ distribution of ⁶⁸Ga-DOTATATE in patients without neuroendocrine tumors
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Relapsing leishmanial arthritis: report of a tricky localization and evidence of miltefosine diffusion in synovial fluid.

Contejean, Adrien; Ayral, Xavier; Dorlo, Thomas P. C.; Roseboom, Ignace C et al.

Part of Journal of Antimicrobial Chemotherapy, p. 2740-2741, 2021

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• DOI for Relapsing leishmanial arthritis: report of a tricky localization and evidence of miltefosine diffusion in synovial fluid.

Toxicity of pemetrexed during renal impairment explained-Implications for safe treatment

Boosman, René J; Dorlo, Thomas P. C.; de Rouw, Nikki; Burgers, Jacobus A et al.

Part of International Journal of Cancer, p. 1576-1584, 2021

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• DOI for Toxicity of pemetrexed during renal impairment explained-Implications for safe treatment

Blood Parasite Load as an Early Marker to Predict Treatment Response in Visceral Leishmaniasis in Eastern Africa.

Verrest, Luka; Kip, Anke E; Musa, Ahmed M; Schoone, Gerard J et al.

Part of Clinical Infectious Diseases, p. 775-782, 2021

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• DOI for Blood Parasite Load as an Early Marker to Predict Treatment Response in Visceral Leishmaniasis in Eastern Africa.

Investigating the influence of relevant pharmacogenetic variants on the pharmacokinetics and pharmacodynamics of orally administered docetaxel combined with ritonavir.

van Eijk, Maarten; Pluim, Dick; Dorlo, Thomas P C; Marchetti, Serena et al.

Part of The Pharmacogenomics Journal, p. 336-345, 2021

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• DOI for Investigating the influence of relevant pharmacogenetic variants on the pharmacokinetics and pharmacodynamics of orally administered docetaxel combined with ritonavir.

Influence of Malnutrition on the Pharmacokinetics of Drugs Used in the Treatment of Poverty-Related Diseases: A Systematic Review.

Verrest, Luka; Wilthagen, Erica A; Beijnen, Jos H; Huitema, Alwin D R et al.

Part of Clinical Pharmacokinetics, p. 1149-1169, 2021

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• DOI for Influence of Malnutrition on the Pharmacokinetics of Drugs Used in the Treatment of Poverty-Related Diseases: A Systematic Review.

Geographical Variability in Paromomycin Pharmacokinetics Does Not Explain Efficacy Differences between Eastern African and Indian Visceral Leishmaniasis Patients.

Verrest, Luka; Wasunna, Monique; Kokwaro, Gilbert; Aman, Rashid et al.

Part of Clinical Pharmacokinetics, p. 1463-1473, 2021

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• DOI for Geographical Variability in Paromomycin Pharmacokinetics Does Not Explain Efficacy Differences between Eastern African and Indian Visceral Leishmaniasis Patients.

Low antileishmanial drug exposure in HIV-positive visceral leishmaniasis patients on antiretrovirals: an Ethiopian cohort study.

Kip, Anke E; Blesson, Séverine; Alves, Fabiana; Wasunna, Monique et al.

Part of Journal of Antimicrobial Chemotherapy, p. 1258-1268, 2021

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• DOI for Low antileishmanial drug exposure in HIV-positive visceral leishmaniasis patients on antiretrovirals: an Ethiopian cohort study.

A Semi-Mechanistic Population Pharmacokinetic/Pharmacodynamic Model of Bortezomib in Pediatric Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia.

Janssen, Julie M; Dorlo, T P C; Niewerth, D; Wilhelm, A J et al.

Part of Clinical Pharmacokinetics, p. 207-216, 2020

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• DOI for A Semi-Mechanistic Population Pharmacokinetic/Pharmacodynamic Model of Bortezomib in Pediatric Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia.

Population Pharmacokinetics of MCLA-128, a HER2/HER3 Bispecific Monoclonal Antibody, in Patients with Solid Tumors.

de Vries Schultink, Aurelia H M; Bol, Kees; Doornbos, Robert P; Murat, Anastasia et al.

Part of Clinical Pharmacokinetics, p. 875-884, 2020

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• DOI for Population Pharmacokinetics of MCLA-128, a HER2/HER3 Bispecific Monoclonal Antibody, in Patients with Solid Tumors.

Clinical Trial Simulation To Optimize Trial Design for Fludarabine Dosing Strategies in Allogeneic Hematopoietic Cell Transplantation.

Langenhorst, Jurgen B; Dorlo, Thomas P C; van Kesteren, Charlotte; van Maarseveen, Erik M et al.

Part of CPT, p. 272-281, 2020

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• DOI for Clinical Trial Simulation To Optimize Trial Design for Fludarabine Dosing Strategies in Allogeneic Hematopoietic Cell Transplantation.

Population pharmacokinetic analysis of nanoparticle-bound and free camptothecin after administration of NLG207 in adults with advanced solid tumors.

Schmidt, Keith T; Huitema, Alwin D R; Dorlo, Thomas P C; Peer, Cody J et al.

Part of Cancer Chemotherapy and Pharmacology, p. 475-486, 2020

Article in journal

• DOI for Population pharmacokinetic analysis of nanoparticle-bound and free camptothecin after administration of NLG207 in adults with advanced solid tumors.

Characterizing the non-linear pharmacokinetics of miltefosine in paediatric visceral leishmaniasis patients from Eastern Africa.

Palić, Semra; Kip, Anke E; Beijnen, Jos H; Mbui, Jane et al.

Part of Journal of Antimicrobial Chemotherapy, p. 3260-3268, 2020

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• DOI for Characterizing the non-linear pharmacokinetics of miltefosine in paediatric visceral leishmaniasis patients from Eastern Africa.

Quantification of the pharmacokinetic-toxicodynamic relationship of oral docetaxel co-administered with ritonavir.

Yu, Huixin; Janssen, Julie M; de Weger, Vincent A; Nuijen, Bastiaan et al.

Part of Investigational new drugs, p. 1526-1532, 2020

Article in journal

• DOI for Quantification of the pharmacokinetic-toxicodynamic relationship of oral docetaxel co-administered with ritonavir.

Evaluation of Extrapolation Methods to Predict Trough Concentrations to Guide Therapeutic Drug Monitoring of Oral Anticancer Drugs.

Janssen, Julie M; Dorlo, Thomas P C; Beijnen, Jos H; Huitema, Alwin D R

Part of Therapeutic Drug Monitoring, p. 532-539, 2020

Article in journal

• DOI for Evaluation of Extrapolation Methods to Predict Trough Concentrations to Guide Therapeutic Drug Monitoring of Oral Anticancer Drugs.

Highly sensitive UPLC-MS/MS method for the quantification of paromomycin in human plasma.

Roseboom, Ignace C; Thijssen, Bas; Rosing, Hilde; Mbui, Jane et al.

Part of Journal of Pharmaceutical and Biomedical Analysis, p. 113245, 2020

Article in journal

• DOI for Highly sensitive UPLC-MS/MS method for the quantification of paromomycin in human plasma.

Pharmacokinetic Targets for Therapeutic Drug Monitoring of Small Molecule Kinase Inhibitors in Pediatric Oncology.

Janssen, Julie M; Dorlo, Thomas P C; Steeghs, Neeltje; Beijnen, Jos H et al.

Part of Clinical Pharmacology and Therapeutics, p. 494-505, 2020

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• DOI for Pharmacokinetic Targets for Therapeutic Drug Monitoring of Small Molecule Kinase Inhibitors in Pediatric Oncology.

Skin tissue sample collection, sample homogenization, and analyte extraction strategies for liquid chromatographic mass spectrometry quantification of pharmaceutical compounds.

Roseboom, Ignace C; Rosing, Hilde; Beijnen, Jos H; Dorlo, Thomas P C

Part of Journal of Pharmaceutical and Biomedical Analysis, p. 113590, 2020

Article in journal

• DOI for Skin tissue sample collection, sample homogenization, and analyte extraction strategies for liquid chromatographic mass spectrometry quantification of pharmaceutical compounds.

Pharmacokinetics, Safety, and Efficacy of an Allometric Miltefosine Regimen for the Treatment of Visceral Leishmaniasis in Eastern African Children: An Open-label, Phase II Clinical Trial.

Mbui, Jane; Olobo, Joseph; Omollo, Raymond; Solomos, Alexandra et al.

Part of Clinical Infectious Diseases, p. 1530-1538, 2019

Article in journal

• DOI for Pharmacokinetics, Safety, and Efficacy of an Allometric Miltefosine Regimen for the Treatment of Visceral Leishmaniasis in Eastern African Children: An Open-label, Phase II Clinical Trial.

Does Older Age Lead to Higher Risk for Neutropenia in Patients Treated with Paclitaxel?

Crombag, Marie-Rose B S; Koolen, Stijn L W; Wijngaard, Sophie; Joerger, Markus et al.

Part of Pharmaceutical research, p. 163, 2019

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• DOI for Does Older Age Lead to Higher Risk for Neutropenia in Patients Treated with Paclitaxel?

Fludarabine exposure in the conditioning prior to allogeneic hematopoietic cell transplantation predicts outcomes.

Langenhorst, J B; van Kesteren, C; van Maarseveen, E M; Dorlo, T P C et al.

Part of Blood Advances, p. 2179-2187, 2019

Article in journal

• DOI for Fludarabine exposure in the conditioning prior to allogeneic hematopoietic cell transplantation predicts outcomes.

Exposure to Docetaxel in the Elderly Patient Population: a Population Pharmacokinetic Study.

Crombag, Marie-Rose B S; Dorlo, Thomas P C; van der Pan, Ellen; van Straten, Anoek et al.

Part of Pharmaceutical research, p. 181, 2019

Article in journal

• DOI for Exposure to Docetaxel in the Elderly Patient Population: a Population Pharmacokinetic Study.

Impact of Older Age on the Exposure of Paclitaxel: a Population Pharmacokinetic Study.

Crombag, Marie-Rose B S; de Vries Schultink, Aurelia H M; Koolen, Stijn L W; Wijngaard, Sophie et al.

Part of Pharmaceutical research, p. 33, 2019

Article in journal

• DOI for Impact of Older Age on the Exposure of Paclitaxel: a Population Pharmacokinetic Study.

Population Pharmacokinetics of Fludarabine in Children and Adults during Conditioning Prior to Allogeneic Hematopoietic Cell Transplantation.

Langenhorst, Jurgen B; Dorlo, Thomas P C; van Maarseveen, Erik M; Nierkens, Stefan et al.

Part of Clinical Pharmacokinetics, p. 627-637, 2019

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• DOI for Population Pharmacokinetics of Fludarabine in Children and Adults during Conditioning Prior to Allogeneic Hematopoietic Cell Transplantation.

Systematic Review of Host-Mediated Activity of Miltefosine in Leishmaniasis through Immunomodulation.

Palić, Semra; Bhairosing, Patrick; Beijnen, Jos H; Dorlo, Thomas P C

Part of Antimicrobial Agents and Chemotherapy, 2019

Article in journal

• DOI for Systematic Review of Host-Mediated Activity of Miltefosine in Leishmaniasis through Immunomodulation.

Safe mass drug administration for neglected tropical diseases.

de Souza, Dziedzom K; Dorlo, Thomas P C

Part of The Lancet Global Health, 2018

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• DOI for Safe mass drug administration for neglected tropical diseases.

Pharmacodynamic modeling of cardiac biomarkers in breast cancer patients treated with anthracycline and trastuzumab regimens.

de Vries Schultink, Aurelia H M; Boekhout, Annelies H; Gietema, Jourik A; Burylo, Artur M et al.

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 431-442, 2018

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• DOI for Pharmacodynamic modeling of cardiac biomarkers in breast cancer patients treated with anthracycline and trastuzumab regimens.

Macrophage Activation Marker Neopterin: A Candidate Biomarker for Treatment Response and Relapse in Visceral Leishmaniasis.

Kip, Anke E; Wasunna, Monique; Alves, Fabiana; Schellens, Jan H M et al.

Part of Frontiers in Cellular and Infection Microbiology, p. 181, 2018

Article in journal

• DOI for Macrophage Activation Marker Neopterin: A Candidate Biomarker for Treatment Response and Relapse in Visceral Leishmaniasis.

Simultaneous population pharmacokinetic modelling of plasma and intracellular PBMC miltefosine concentrations in New World cutaneous leishmaniasis and exploration of exposure-response relationships.

Kip, Anke E; Castro, María Del Mar; Gomez, Maria Adelaida; Cossio, Alexandra et al.

Part of Journal of Antimicrobial Chemotherapy, p. 2104-2111, 2018

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• DOI for Simultaneous population pharmacokinetic modelling of plasma and intracellular PBMC miltefosine concentrations in New World cutaneous leishmaniasis and exploration of exposure-response relationships.

Population Pharmacokinetics of Artemether, Dihydroartemisinin, and Lumefantrine in Rwandese Pregnant Women Treated for Uncomplicated Plasmodium falciparum Malaria

Lohy Das, Jesmin; Rulisa, Stephen; de Vries, Peter J.; Mens, Petra F. et al.

Part of Antimicrobial Agents and Chemotherapy, 2018

Article in journal

• DOI for Population Pharmacokinetics of Artemether, Dihydroartemisinin, and Lumefantrine in Rwandese Pregnant Women Treated for Uncomplicated Plasmodium falciparum Malaria

Clinical Pharmacokinetics of Systemically Administered Antileishmanial Drugs

Kip, Anke E.; Schellens, Jan H. M.; Beijnen, Jos H.; Dorlo, Thomas P. C.

Part of Clinical Pharmacokinetics, p. 151-176, 2018

Article, review/survey

• DOI for Clinical Pharmacokinetics of Systemically Administered Antileishmanial Drugs
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Evaluation Of Macrophage Activation Marker Neopterin As A Pharmacodynamic Biomarker In Visceral Leishmaniasis

Kip, Antonia E.; Musa, Ahmed; Khalil, Eltahiri A.; Wassuna, Monique et al.

Part of American Journal of Tropical Medicine and Hygiene, p. 162-163, 2017

Article in journal

Immunomodulatory Therapy of Visceral Leishmaniasis in Human Immunodeficiency Virus-Coinfected Patients.

Adriaensen, Wim; Dorlo, Thomas P C; Vanham, Guido; Kestens, Luc et al.

Part of Frontiers in Immunology, p. 1943, 2017

Article in journal

• DOI for Immunomodulatory Therapy of Visceral Leishmaniasis in Human Immunodeficiency Virus-Coinfected Patients.

Letter by Dorlo Regarding Article, "Acupuncture Therapy and Incidence of Depression After Stroke".

Dorlo, Thomas P C

Part of Stroke, 2017

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• DOI for Letter by Dorlo Regarding Article, "Acupuncture Therapy and Incidence of Depression After Stroke".

Pharmacokinetics of Miltefosine in Children and Adults with Cutaneous Leishmaniasis

Castro, María Del Mar; Gomez, Maria Adelaida; Kip, Anke E.; Cossio, Alexandra et al.

Part of Antimicrobial Agents and Chemotherapy, 2017

Article in journal

• DOI for Pharmacokinetics of Miltefosine in Children and Adults with Cutaneous Leishmaniasis

Volumetric absorptive microsampling (VAMS) as an alternative to conventional dried blood spots in the quantification of miltefosine in dried blood samples.

Kip, A E; Kiers, K C; Rosing, H; Schellens, J H M et al.

Part of Journal of Pharmaceutical and Biomedical Analysis, p. 160-166, 2017

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• DOI for Volumetric absorptive microsampling (VAMS) as an alternative to conventional dried blood spots in the quantification of miltefosine in dried blood samples.