Neuropsychopharmacology

Focusing on psychoneurobiology, activities of the group include:

research on the molecular underpinnings of gonadal hormones´influence on women’s behaviour and mental health; by employing genetic, endocrine, pharmacological, neurophysiological and neuroimaging measures, we aim to characterize diagnosis- and treatment-related biomarkers of sex-specific disorders.
research on the effects of early-life stress and alcohol exposure on brain and behaviour; (epi)gene-environment interactions are investigated in rodents as well as human population-based samples, with special focus on adolescence, to identify biomarkers of vulnerability to alcohol use and misuse.

Group members

Group members: Anat Biegon, Julia Breedh, Elise Büecklein, Manon Dubol, Ann-Christin Kimmig, Gloria Matte Bon, Mirac Nur Musaoglu, Ella Schleimann-Jensen, Elin Stenhammar, Ylva Walldén, Zoë van Loenen, Christina Zjukovskaja

Publications

White matter integrity upon progesterone antagonism in individuals with premenstrual dysphoric disorder: A randomized placebo-controlled diffusion tensor imaging study

Kaltsouni, Elisavet; Gu, Xuan; Wikström, Johan; Hahn, Andreas et al.

Part of Progress in Neuro-psychopharmacology and Biological Psychiatry, 2025
- DOI for White matter integrity upon progesterone antagonism in individuals with premenstrual dysphoric disorder: A randomized placebo-controlled diffusion tensor imaging study
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Progestagens and progesterone receptor modulation: Effects on the brain, mood, stress, and cognition in females

Bencker, Celine; Gschwandtner, Laura; Nayman, Sibel; Nguyen, Billie et al.

Part of Frontiers in Neuroendocrinology, 2025
- DOI for Progestagens and progesterone receptor modulation: Effects on the brain, mood, stress, and cognition in females
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Emotion regulation-based internet-delivered cognitive behavioural therapy for premenstrual dysphoric disorder: study protocol for a randomised controlled trial in Sweden

Motilla Hoppe, Johanna; Weise, Cornelia; Kleinstaeuber, Maria; Skalkidou, Alkistis et al.

Part of BMJ Open, 2025
- DOI for Emotion regulation-based internet-delivered cognitive behavioural therapy for premenstrual dysphoric disorder: study protocol for a randomised controlled trial in Sweden
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The impact of pharmacotherapy for premenstrual dysphoric disorder on sleep

Meth, Elisa; Noga Morais Ferreira, Diana; Dubol, Manon; Xue, Pei et al.

Part of Sleep Medicine Reviews, 2025
- DOI for The impact of pharmacotherapy for premenstrual dysphoric disorder on sleep
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Preventing suicide with Safe Alternatives for Teens and Youths (SAFETY): a randomised feasibility trial

Karemyr, Moa; Bellander, Martin; Ponten, Moa; Ohlis, Anna et al.

Part of BMJ Mental Health, 2025
- DOI for Preventing suicide with Safe Alternatives for Teens and Youths (SAFETY): a randomised feasibility trial
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Climate change impacts the symptomology and healthcare of multiple sclerosis patients through fatigue and heat sensitivity: A systematic review

Ghaderi Berntsson, Shala; Reis, Jacques; Zjukovskaja, Christina; Tulek, Zeliha et al.

Part of Journal of the Neurological Sciences, 2025
- DOI for Climate change impacts the symptomology and healthcare of multiple sclerosis patients through fatigue and heat sensitivity: A systematic review
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Transcription of GABA_A receptor subunits in circulating monocytes and association to emotional brain function in premenstrual dysphoric disorder

Stiernman, Louise; Comasco, Erika; Johansson, Maja; Bixo, Marie

Part of Translational Psychiatry, 2025
- DOI for Transcription of GABA_A receptor subunits in circulating monocytes and association to emotional brain function in premenstrual dysphoric disorder
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Pain threshold and pain tolerance in young people with self-injurious behavior: A systematic review and meta-analysis

Pontén, Moa; Lee, Maria; Khoo, Samantha; Nilsson, Georg et al.

Part of Psychiatry Research, 2025
- DOI for Pain threshold and pain tolerance in young people with self-injurious behavior: A systematic review and meta-analysis
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Trajectories and dimensional phenotypes of depressive symptoms throughout pregnancy and postpartum in relation to prior premenstrual symptoms

Ella, Schleimann-Jensen; Sundström Poromaa, Inger; Meltzer-Brody, Samantha; Eisenlohr-Moul, Tory A. et al.

Part of British Journal of Psychiatry, p. 401-409, 2025
- DOI for Trajectories and dimensional phenotypes of depressive symptoms throughout pregnancy and postpartum in relation to prior premenstrual symptoms
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Brain correlates of antidepressant treatment in premenstrual dysphoric disorder

Dubol, Manon; Sundström-Poromaa, Inger; Comasco, Erika

2025
Subjective, behavioural and physiological correlates of stress in women using hormonal contraceptives

Bürger, Zoé; Kordowich, Charlotte; Kübbeler, Julia; Müllerschön, Carolin et al.

Part of British Journal of Psychiatry, p. 392-400, 2025
- DOI for Subjective, behavioural and physiological correlates of stress in women using hormonal contraceptives
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Psychiatric symptoms on the ovarian hormone roller-coaster

Comasco, Erika; Epperson, C. Neill; Kulkarni, Jayashri

Part of British Journal of Psychiatry, p. 329-330, 2025
- DOI for Psychiatric symptoms on the ovarian hormone roller-coaster
Longitudinal development of sex differences in the limbic system is associated with age, puberty and mental health

Matte Bon, Gloria; Walther, Jonas; Comasco, Erika; Derntl, Birgit et al.

Part of Communications Biology, 2025
- DOI for Longitudinal development of sex differences in the limbic system is associated with age, puberty and mental health
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Trait- versus state- grey matter volume alterations in premenstrual dysphoric disorder

Stiernman, Louise; Dubol, Manon; Sundström Poromaa, Inger; Bixo, Marie et al.

Part of BMC Psychiatry, 2025
- DOI for Trait- versus state- grey matter volume alterations in premenstrual dysphoric disorder
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White Matter Regional Volumes in Relation to Menstrual Cycle Phase and Premenstrual Dysphoric Disorder

Stenhammar, Elin; Dubol, Manon; Stiernman, Louise; Sundström Poromaa, Inger et al.

Part of Biological Psychiatry, 2025
- DOI for White Matter Regional Volumes in Relation to Menstrual Cycle Phase and Premenstrual Dysphoric Disorder
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Contextualizing Telomere Biology Through Biopsychological Plasticity: Insights From the Differential Susceptibility Hypothesis

Comasco, Erika

Part of Biological Psychiatry, 2025
- DOI for Contextualizing Telomere Biology Through Biopsychological Plasticity: Insights From the Differential Susceptibility Hypothesis
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Examining Temporal and Dynamic Profiles of Premenstrual Dysphoric Disorder Symptoms

Ella, Schleimann-Jensen; Sundström Poromaa, Inger; Comasco, Erika

2025
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Temporal and dynamic profiling of premenstrual dysphoric disorder symptoms

Ella, Schleimann-Jensen; Sundström Poromaa, Inger; Comasco, Erika

2025
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Association of estrogen receptor single nucleotide polymorphisms and perinatal depression

Duque Björvang, Richelle; Gumbo, Lulu Francis; Årdahl, Anders; Lager, Susanne et al.

Part of PLOS ONE, 2025
- DOI for Association of estrogen receptor single nucleotide polymorphisms and perinatal depression
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Emotion Generation and Regulation in Premenstrual Dysphoric Disorder: Dysregulation of Large-Scale Brain Networks Across the Menstrual Cycle

Stiernman, Louise; Dubol, Manon; Comasco, Erika; Johansson, Maja et al.

Part of Biological Psychiatry, 2025
- DOI for Emotion Generation and Regulation in Premenstrual Dysphoric Disorder: Dysregulation of Large-Scale Brain Networks Across the Menstrual Cycle
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Differentially expressed transcripts associated with depressive symptoms during pregnancy and postpartum

Björvang, Richelle D.; Vrettou, Maria; Bujanda Cundin, Xabier; Del Prete, Eugenio et al.

Part of Molecular Psychiatry, p. 4736-4748, 2025
- DOI for Differentially expressed transcripts associated with depressive symptoms during pregnancy and postpartum
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Genetic variation of the estrogen receptor and its association with depression and anxiety symptoms in young females

Musaoglu, Mirac Nur; Olofsdotter, Susanne; Vadlin, Sofia; Åslund, Cecilia et al.

Part of Progress in Neuro-psychopharmacology and Biological Psychiatry, 2025
- DOI for Genetic variation of the estrogen receptor and its association with depression and anxiety symptoms in young females
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Aromatase, sex hormones and the young adult brain

Immenschuh, Jana

2024
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How sex and gender shape functional brain networks

Matte Bon, Gloria; Kraft, Dominik; Kaufmann, Tobias

Part of Science Advances, 2024
- DOI for How sex and gender shape functional brain networks
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Association of polygenic scores for autism with volumetric MRI phenotypes in cerebellum and brainstem in adults

Mohammad, Salahuddin; Gentreau, Mélissa; Dubol, Manon; Rukh, Gull et al.

Part of Molecular Autism, 2024
- DOI for Association of polygenic scores for autism with volumetric MRI phenotypes in cerebellum and brainstem in adults
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Modeling brain sex in the limbic system as phenotype for female-prevalent mental disorders

Matte Bon, Gloria; Kraft, Dominik; Comasco, Erika; Derntl, Birgit et al.

Part of Biology of Sex Differences, 2024
- DOI for Modeling brain sex in the limbic system as phenotype for female-prevalent mental disorders
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Cortical morphology variations during the menstrual cycle in individuals with and without premenstrual dysphoric disorder

Dubol, Manon; Stiernman, Louise; Sundström Poromaa, Inger; Bixo, Marie et al.

Part of Journal of Affective Disorders, p. 470-477, 2024
- DOI for Cortical morphology variations during the menstrual cycle in individuals with and without premenstrual dysphoric disorder
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Electroencephalography findings in menstrually-related mood disorders: A critical review

Kaltsouni, Elisavet; Schmidt, Felix; Zsido, Rachel G.; Eriksson, Allison et al.

Part of Frontiers in Neuroendocrinology, 2024
- DOI for Electroencephalography findings in menstrually-related mood disorders: A critical review
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White matter volume and treatment with selective progesterone receptor modulator in patients with premenstrual dysphoric disorder

Kaltsouni, Elisavet; Wikström, Johan; Lanzenberger, Rupert; Sundström Poromaa, Inger et al.

Part of Psychoneuroendocrinology, 2024
- DOI for White matter volume and treatment with selective progesterone receptor modulator in patients with premenstrual dysphoric disorder
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Peripartum depression symptom trajectories, telomere length and genotype, and adverse childhood experiences

Vrettou, Maria; Lager, Susanne; Toffoletto, Simone; Iliadis, Stavros I. et al.

Part of BMC Psychiatry, 2024
- DOI for Peripartum depression symptom trajectories, telomere length and genotype, and adverse childhood experiences
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Mental health trajectories and dimensional phenotypes throughout pregnancy and postpartum in relation to pre-pregnancy premenstrual symptoms

Schleimann-Jensen, Ella; Skalkidou, Alkistis; Comasco, Erika

2024
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Mid-pregnancy allopregnanolone levels and trajectories of perinatal depressive symptoms

Björvang, Richelle D.; Walldén, Ylva; Fransson, Emma; Comasco, Erika et al.

Part of Psychoneuroendocrinology, 2024
- DOI for Mid-pregnancy allopregnanolone levels and trajectories of perinatal depressive symptoms
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Removing scanner effects with a multivariate latent approach: A RELIEF for the ABCD imaging data?

Kraft, Dominik; Matte Bon, Gloria; Breton, Edith; Seidel, Philipp et al.

Part of IMAGING NEUROSCIENCE, p. 1-7, 2024
- DOI for Removing scanner effects with a multivariate latent approach: A RELIEF for the ABCD imaging data?
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New Pharmacological Approaches to the Management of Premenstrual Dysphoric Disorder

Sundström Poromaa, Inger; Comasco, Erika

Part of CNS Drugs, p. 371-379, 2023
- DOI for New Pharmacological Approaches to the Management of Premenstrual Dysphoric Disorder
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Emotion-induced brain activation across the menstrual cycle in individuals with premenstrual dysphoric disorder and associations to serum levels of progesterone-derived neurosteroids

Stiernman, Louise; Dubol, Manon; Comasco, Erika; Sundström Poromaa, Inger et al.

Part of Translational Psychiatry, 2023
- DOI for Emotion-induced brain activation across the menstrual cycle in individuals with premenstrual dysphoric disorder and associations to serum levels of progesterone-derived neurosteroids
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Editorial: Effects of hormonal contraceptives on the brain

Pletzer, Belinda; Comasco, Erika; Hidalgo-Lopez, Esmeralda; Lacreuse, Agnès et al.

Part of Frontiers in Endocrinology, 2023
- DOI for Editorial: Effects of hormonal contraceptives on the brain
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Acute nicotine exposure blocks aromatase in the limbic brain of healthy women: A [11C]cetrozole PET study

Dubol, Manon; Immenschuh, Jana; Jonasson, My; Takahashi, Kayo et al.

Part of Comprehensive Psychiatry, 2023
- DOI for Acute nicotine exposure blocks aromatase in the limbic brain of healthy women: A [11C]cetrozole PET study
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Premenstrual symptoms and depression during pregnancy and postpartum in two large cohorts of pregnant women

Schleimann-Jensen, Ella; Comasco, Erika; Skalkidou, Alkistis

2023
Levonorgestrel intrauterine device and depression: A Swedish register-based cohort study

Stenhammar, Elin; Wikman, Per; Danielsson, Kristina Gemzell; Kopp-Kallner, Helena et al.

Part of International Journal of Psychophysiology, 2023
- DOI for Levonorgestrel intrauterine device and depression: A Swedish register-based cohort study
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Differential grey matter structure in women with premenstrual dysphoric disorder: evidence from brain morphometry and data-driven classification

Dubol, Manon; Stiernman, Louise; Wikström, Johan; Lanzenberger, Rupert et al.

Part of Translational Psychiatry, 2022
- DOI for Differential grey matter structure in women with premenstrual dysphoric disorder: evidence from brain morphometry and data-driven classification
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Grey matter morphology in women with premenstrual dysphoric disorder treated with a selective progesterone receptor modulator.

Kaltsouni, Elisavet; Dubol, Manon; Wikström, Johan; Lanzenberger, Rupert et al.

Part of European Neuropsychopharmacology, p. 35-43, 2022
- DOI for Grey matter morphology in women with premenstrual dysphoric disorder treated with a selective progesterone receptor modulator.
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Grey matter correlates of affective and somatic symptoms of premenstrual dysphoric disorder

Dubol, Manon; Wikström, Johan; Lanzenberger, Rupert; Epperson, C. Neill et al.

Part of Scientific Reports, 2022
- DOI for Grey matter correlates of affective and somatic symptoms of premenstrual dysphoric disorder
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Exploring the relationship between early life adversity, telomere length and peripartum depression

Vrettou, Maria; Toffoletto, Simone; Lager, Susanne; Skalkidou, Alkistis et al.

2022
DNA methylation of Vesicular Glutamate Transporters in the mesocorticolimbic brain following early-life stress and adult ethanol exposure-an explorative study

Vrettou, Maria; Yan, Liying; Nilsson, Kent W.; Wallén-Mackenzie, Åsa et al.

Part of Scientific Reports, 2021
- DOI for DNA methylation of Vesicular Glutamate Transporters in the mesocorticolimbic brain following early-life stress and adult ethanol exposure-an explorative study
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DNA methylation in cord blood in association with prenatal depressive symptoms

Kunovac Kallak, Theodora; Bränn, Emma; Fransson, Emma; Johansson, Åsa et al.

Part of Clinical Epigenetics, 2021
- DOI for DNA methylation in cord blood in association with prenatal depressive symptoms
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Association of levonorgestrel intrauterine devices with stress reactivity, mental health, quality of life and sexual functioning: A systematic review

Bürger, Zoe; Bucher, Anna Magdalena; Comasco, Erika; Henes, Melanie et al.

Part of Frontiers in Neuroendocrinology, 2021
- DOI for Association of levonorgestrel intrauterine devices with stress reactivity, mental health, quality of life and sexual functioning: A systematic review
Brain reactivity during aggressive response in women with premenstrual dysphoric disorder treated with a selective progesterone receptor modulator

Kaltsouni, Elisavet; Fisher, Patrick M.; Dubol, Manon; Hustad, Steinar et al.

Part of Neuropsychopharmacology, p. 1460-1467, 2021
- DOI for Brain reactivity during aggressive response in women with premenstrual dysphoric disorder treated with a selective progesterone receptor modulator
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Ulipristal Acetate for Treatment of Premenstrual Dysphoric Disorder: A Proof-of-Concept Randomized Controlled Trial

Comasco, Erika; Kallner, Helena Kopp; Bixo, Marie; Hirschberg, Angelica L. et al.

Part of American Journal of Psychiatry, p. 256-265, 2021
- DOI for Ulipristal Acetate for Treatment of Premenstrual Dysphoric Disorder: A Proof-of-Concept Randomized Controlled Trial
Neuroimaging the menstrual cycle: A multimodal systematic review

Dubol, Manon; Epperson, C. Neill; Sacher, Julia; Pletzer, Belinda et al.

Part of Frontiers in neuroendocrinology (Print), 2021
- DOI for Neuroimaging the menstrual cycle: A multimodal systematic review
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Neuroimaging premenstrual dysphoric disorder: A systematic and critical review

Dubol, Manon; Epperson, C. Neill; Lanzenberger, Rupert; Sundström Poromaa, Inger et al.

Part of Frontiers in neuroendocrinology (Print), 2020
- DOI for Neuroimaging premenstrual dysphoric disorder: A systematic and critical review