Research at Uppsala University

• Development of a proof of concept for a cell-based method for potency determination of Botulinum toxin

  Research project from 2019-12-01 to 2022-12-31

  We will within this project develop a proof of concept assay to replace Botulinum Toxin type A (BoNT/A) testing in animals. Our assay is a cell based assay, based on human embryonic stem cells. These cells ...

• Deep multi-scale modeling of pH effect on the dissolution of metal oxide nanoparticles

  Research project from 2020-01-01 to 2023-12-31

  Several nanosafety projects have been funded by the EU (e.g. EU Nanosafety Cluster and SmartNanoTox), however, the standardized process to assess and to predict the toxicity of metal oxide nanoparticles ...

• Earth´s past environmental crises: Large Igneous Provinces and sedimentary basins

  Research project from 2019-01-01 to 2022-12-31

  Large Igneous Provinces (LIPs) are of enduring interest to scientists and the general public because of their link to paleoclimate change, mass extinctions, evolution of life, and economic ore deposits ...

• Immunity in a changing world: the role of migration on the evolution of the immune system of birds

  Research project from 2020-07-01 to 2023-06-30

  Pathogens and parasites exert the strongest selection pressures on earth, shaping the evolution of an effective and efficient immune system. However, the geographic distribution of pathogens is hypothesized ...

• Konsistens och uthållighet: Verifiering av parallella program på icke-flyktiga minnen

  Research project from 2020-12-01 to 2024-11-30

  Nonvolatile memories (NVRAMs)} offer the best of two worlds, namely the low latency of DRAM, and the persistency of long term storage.They provide direct access to data in the same way as DRAM, but allow ...

• Regional Carbon Budgets and the rapid transition to a fossil-free energy system

  Research project from 2019-01-01 to 2022-12-31

  The four year project aims to facilitate Sweden’s transition to a 100% renewable energy system by defining required targets and processes. The temperature and equity framing of the Paris Agreement will ...

• Swedish Caribbean Colonialism 1784–1878. Integrating, Classifying, Publishing and Investigating Dispersed Swedish Colonial Archives

  Research project from 2018-01-01 to 2022-12-31

  Sweden’s possession of the Caribbean island of Saint Barthélemy (StB) is inadequately investigated. The Swedish Caribbean Colonialism 1784–1878 project (SweCarCol) integrates, orders and opens up important ...

• The civilian dimension of peacekeeping operations and human rights promotion

  Research project from 2019-01-01 to 2022-12-31

  United Nations (UN) peacekeeping operations have become one of the most prominent responses to civil wars around the world. The role of civilian personnel and their activities have proliferated during ...

• The Torrent Ahead: Algorithms for X-ray Lasers to Study Structure, Function and Dynamics

  Research project from 2019-01-01 to 2024-12-31

  A new generation of superluminous X-ray free-electron lasers (XFEL) will deliver billions of exposures per day at intensities up to 100-times higher than intensities available from existing XFELs. The ...

• 1000 Years of Language Contact: Convergence and Divergence on Gotland

  Research project from 2020-01-01 to 2023-12-31

  Language family histories can resemble genealogies, in which a constant process of diversification produces ‘family trees’. But it is also well-known that language histories are not always tree-like, and ...

• 2D magnets for spintronic and magnonic applications

  Research project from 2020-01-01 to 2023-12-31

  For a very long time, magnetic order in two dimensions was not expected to exist. Everything changed just two years ago when the first-ever 2D ferromagnet, a monolayer of CrI3 was obtained. This finding ...

• 3D-nanoprinted supercapacitors

  Research project from 2019-01-01 to 2022-12-31

  Supercapacitors belong to the top candidates for the next leap in energy storage technology, with better theoretical performance than the currently best batteries for applications in e.g. electric cars ...

• 5G Network Performance: A Mathematical Optimization Perspective

  Research project from 2019-01-01 to 2022-12-31

  Will 5G hold its promise? Whereas a huge amount of efforts is being devoted to addressing the question, the research falls short on understanding, characterizing, and improving network-level performance ...

• A Fundamental Approach to Charge Transfer in Transition Metal 1D Coordination Polymer Materials

  Research project from 2019-01-01 to 2022-12-31

  Charge transporting materials play a cruical role in one of the most active research areas: the development of molecular materials to facilitate the conversion of solar energy into electricity, fuels and ...

• A Resource Efficient Society with sustainable processes for using the waste residue streams from pulp production to produce chemicals for electric energy storage based on reNEWable MATerials (RES-NEWMAT

  Research project from 2019-01-01 to 2023-12-31

  The project has the aim of creating the scientific base for sustainable industrial processes for using the waste-residue streams from pulp production (annually consisting of ~400 Mtons of hemicellulose ...

• A Swedish Earth Biogenome Project platform: building a pipeline and proof of principle studies

  Research project from 2021-01-01 to 2024-12-31

  A grand challenge for humanity is to maintain biodiversity and ensure food safety for the growing population. There is currently an alarming loss of biodiversity due to loss of natural habitats and human ...

• A city-wide preschool yard? Challenges and possibilities for supporting inner city preschools´ mobility and space for play in dense urban environments

  Research project from 2019-12-01 to 2023-11-30

  Public space has become less accessible to children. Research on children’s mobility and play shows a link between compact city policies, heavy traffic, a lack of nearby green and open recreational and ...

• A double-edged sword? Quantifying tradeoffs in CRISPR immunity

  Research project from 2021-01-01 to 2024-12-31

  CRISPR-Cas-based adaptive immune systems are ubiquitous in bacteria and archaea. Paradoxically, CRISPR-associated endonucleases are remarkably slow at locating target DNA, with search times on the order ...

• A new tool for developing of plasmon-driven catalysis for sustainable chemistry

  Research project from 2020-01-01 to 2022-12-31

  Solar energy, being an abundant and easily available energy resource, possesses great potential in driving environmentally benign chemical transformations. Plasmonic nanoparticles have attracted particular ...

• A novel food-based approach for preventing fatty liver disease and managing type 2 diabetes

  Research project from 2020-01-01 to 2022-12-31

  Fatty liver is a common health disorder that precedes liver disease and predicts type 2 diabetes. Lipogenesis is the synthesis of fat from glucose in the liver. Dysregulation of this metabolic pathway ...

• A novel low noise Si nano-sensor for rapid antibiotic susceptibility tests

  Research project from 2020-01-01 to 2023-12-31

  The proposed project aims at developing a novel low-noise Silicon nanowire ion sensor for rapid antibiotic susceptibility tests. The extremely low sensor noise will be achieved by completely replacing ...

• A novel phototransistor for single-molecule detection in electrolytes

  Research project from 2019-01-01 to 2022-12-31

  This project explores a novel phototransistor for its potential of single-molecule detection in electrolytes by exploiting the strengths while avoiding the pitfalls of optical and electrical sensor technologies ...

• A pharmacometric framework for model-based translation of antibiotic effects in vitro to outcomes in patients infected by resistant bacteria

  Research project from 2019-01-01 to 2022-12-31

  Antibiotic resistance is increasing at an alarming rate. There is consequently an urgent need for new approaches that can define efficient dosing strategies and facilitate development of treatments against ...

• A prospective study of the developmental mechanisms of self-regulation and the contributing role of environmental and genetic factors: A novel multidisciplinary approach

  Research project from 2020-01-01 to 2023-12-31

  Why do some people succeed in school and later in life and others do not? Recent studies show very clearly that it is not primarily about social intelligence, physical health, IQ or talent. Instead, it ...

• A sense-and-respond nanocellulose-based delivery platform for wound-healing, bioactive molecules (NanoCellSense)

  Research project from 2019-01-01 to 2022-12-31

  The aim of this project is to lay the scientific foundation for the development of a new generation of nanocellulose-based therapeutic delivery platforms,with focus on the treatment of chronic wounds. ...

• A three dimensional in vitro model of the gut to inform on optimal dosage form design for oral drug delivery

  Research project from 2019-01-01 to 2022-12-31

  The vast majority of modern pharmacologically active compounds demands advanced drug delivery systems (ADDSs) to be developed as orally administered medicines. The goal for this project is to design lab ...

• A unified theory of spin torques for antiferromagnetic spintronics and spin-orbitronics

  Research project from 2019-01-01 to 2022-12-31

  Despite being a mature field of research studying of magnetism and spin-dependent phenomena remains one of the most fascinating area in condensed matter physics. Indeed, progress in technological development ...

• Ameliorating Child poverty through Connecting Economic Services with child health Services (ACCESS): A randomised controlled trial of the Healthier Wealthier Families model in Sweden

  Research project from 2021-07-01 to 2025-06-30

  Background: Poverty is one of the most basic and persistent causes of early childhood adversity. In the first years of life, a critical developmental period, children living in, or on the verge of, poverty ...

• AI based Detection of Acute Respiratory Distress Syndrome (AI-DARDS)

  Research project from 2021-01-01 to 2023-12-31

  Purpose and goal: The aim of this project is to develop and complete a new medical technology system AI-DARDS, to enable healthcare in rural areas and in smaller towns to be diagnosed, monitored, and ...

• EXPlainable and Learning production & logistics by Artificial INtelligence (EXPLAIN)

  Research project from 2021-04-15 to 2024-04-14

  Purpose and goal: The aim of the EXPLAIN is to increase the profitability, sustainability, and competitiveness of the Swedish manufacturing industry. The project conducts research & development of a new ...

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