Research at Uppsala University

• Accelerated Early staGe drug diScovery

  Research project from 2016-01-01 to 2020-01-01

  The development of effective novel drugs - especially for rare and neglected diseases - is one of the biggest challenges of the upcoming decades, as illustrated by the recent Ebola outbreak. Moreover, ...

• Advanced aRchitectures for ultra-thin high-efficiency CIGS solar cells with high Manufacturability

  Research project from 2016-12-01 to 2019-11-30

  Advanced aRchitectures for ultra-thin high-efficiency CIGS solar cells with high Manufacturability (ARCIGS-M) This project´s goal is advanced materials and nanotechnologies for novel CIGS PV device architectures ...

• Alphaviral Immunotherapy against Glioblastoma

  Research project from 2016-05-01 to 2018-04-30

  Alphaviral Immunotherapy against Glioblastoma Glioblastomas (GBM) are the most frequent type of primary brain tumours with no treatment or cure available. Despite the current standard care, GBMs remain ...

• Bridging the gap: an evolutionary genomics approach to illuminate the prokaryote-to-eukaryote transition.

  Research project from 2017-01-01 to 2018-12-31

  Eukarya – one of the three Domains of Life along with Archaea and Bacteria (i.e. prokaryotes) – include all complex multicellular life forms, as well as a colossal diversity of unicellular microorganisms ...

• Chemistry and Biology in Synergy - Studies of hydrogenases using a combination of synthetic chemistry and biological tools

  Research project from 2017-02-01 to 2022-01-31

  My proposal aims to take advantage of my ground-breaking finding that it is possible to mature, or activate, the [FeFe] hydrogenase enzyme (HydA) using synthetic mimics of its catalytic [2Fe] cofactor. ...

• Combining Single Molecule and Ensemble approaches To Investigate Cas9 Target Search

  Research project from 2016-04-01 to 2018-03-31

  The CRISPR-Cas9 bacterial immune system has garnered intense interest both as a synthetic biology tool and as a biological system in its own right. Yet the ability of Cas9 to find its guide-RNA-directed ...

• Contexts, networks and participation: The social logic of political engagement

  Research project from 2016-09-01 to 2021-08-31

  The statement that individuals’ immediate social circumstances influence how they think and act in the political sphere is a truism. However, both theoretical and empirical considerations have often prevented ...

• Coordination and Composability: The Keys to Efficient Memory System Design

  Research project from 2017-03-01 to 2022-02-28

  Computer systems today are power limited. As a result, efficiency gains can be translated into performance. Over the past decade we have been so effective at making computation more efficient that we are ...

• Digital readout of protein detection via super rolling circle amplification of DNA tags

  Research project from 2015-10-01 to 2017-03-31

  This project will serve to evaluate market opportunities of a newly invented technology for digital detection of reporter DNA strands in protein analysis. The purpose of my ongoing ERC project ProteinSeq ...

• Dynamics of Supersymmetry in Curved Space

  Research project from 2015-09-01 to 2020-08-31

  Quantum field theory provides a theoretical framework to explain quantitatively natural phenomena as diverse as the fluctuations in the cosmic microwave background, superconductivity, and elementary particle ...

• EPOS Implementation Phase

  Research project from 2015-10-01 to 2019-10-01

  The nations of Europe are distributed around some of the most complex and dynamic geological systems on the planet and understanding these is essential to the security of livelihoods and economic power ...

• Evolutionary Stability of Ubiquitous Root Symbiosis

  Research project from 2016-04-01 to 2021-03-31

  Virtually all terrestrial plants depend on symbiotic interactions with fungi. Arbuscular mycorrhizal (AM) fungi evolved over 450 million years ago, are obligate biotrophs and cannot complete their lifecycle ...

• Fundamental and Applied Science on Molecular Redox-Catalysts of Energy Relevance in Metal-Organic Frameworks

  Research project from 2017-01-01 to 2021-12-31

  Organometallic redox-catalysts of energy relevance, i.e. water and hydrogen oxidation, and proton and carbon dioxide reduction catalysts, will be incorporated into metal-organic frameworks (MOFs). Immobilization ...

• Integrating spatial and genetic information via automated image analysis and interactive visualization of tissue data

  Research project from 2016-04-01 to 2021-03-31

  Digital imaging of tissue samples and genetic analysis by next generation sequencing are two rapidly emerging fields in pathology. The exponential growth in digital imaging in pathology is catalyzed by ...

• Intestinal Lipoidal Nanostructures - A Lipid Bridge to Increased Drug Delivery

  Research project from 2015-09-01 to 2020-08-31

  My research program explores molecular interplay between drug, dosage form and the complex environment of the gastrointestinal tract (GIT). Drug molecules currently being discovered to cure e.g. CNS diseases ...

• Jigsaw puzzles at atomic resolution: Computational design of GPCR drugs from fragments

  Research project from 2017-11-01 to 2022-10-31

  Despite technological advances, industry struggles to develop new pharmaceuticals and therefore novel strategies for drug discovery are urgently needed. G protein-coupled receptors (GPCRs) play important ...

• Molecularly defined models of human childhood brain tumors

  Research project from 2015-05-01 to 2020-04-30

  MYC proteins like MYC and MYCN are transcription factors that are mis-regulated in more than half of all types of human cancer including medulloblastoma, the most common brain malignancy in children. The ...

• Mosaic loss of chromosome Y (LOY) in blood cells - a new biomarker for risk of cancer and Alzheimer’s disease in men

  Research project from 2016-03-01 to 2021-02-28

  My recent discoveries show that mosaic loss of chromosome Y (LOY) in peripheral blood is associated with increased risks of cancer and Alzheimer’s disease (AD). These conditions are responsible for >50% ...

• Organ-specific mechanisms of lymphatic vascular development and specialisation

  Research project from 2015-05-01 to 2020-04-30

  Lymphatic vasculature maintains tissue fluid homeostasis and has important emerging roles in inflammation, immunity, lipid metabolism, blood pressure regulation and cancer metastasis. Lymphatic vessels ...

• Patient Preferences in benefit risk assessments during the drug life cycle

  Research project from 2016-11-16 to 2021-09-30

  The PREFER project will deliver an overview and evaluation of preference elicitation methods to be applied in the entire drug life cycle, i.e. in the early stages of identifying medical needs, in clinical ...

• Promoting SINgle cell GEnomics to explore the ecology and evolution of hidden microeuKaryotes

  Research project from 2016-01-01 to 2020-01-01

  Environmental microbial surveys have revealed a remarkable diversity of microeukaryotic life in most ecosystems, the majority of which had previously escaped detection. From an ecological point of view ...

• Single-Molecule And Structural Studies Of ATP-Dependent Chromatin Remodelling

  Research project from 2017-03-01 to 2022-02-28

  The packaging of genetic information into chromatin regulates a wide range of vital processes that depend on direct access to the DNA template. Many chromatin-interacting complexes impact chromatin structure ...

• Soccermatics: data for football fans and clubs

  Research project from 2017-08-01 to 2019-01-31

  Data plays an increasingly important role in sport, from monitoring of fitness of athletes to success statistics in baseball. In football (soccer) the team performance is more important than the performance ...

• Spore killer genomics: elucidating causes and consequences of a fungal meiotic drive element

  Research project from 2015-05-01 to 2020-04-30

  The traditional view of the genome is that of a highly coordinated network that has evolved to produce a successful individual. However, the alternative view of the genome as containing intrinsically conflicting ...

• Temporality of permanence –material and socio-spatial practices in African urbanism

  Research project from 2015-09-14 to 2018-05-13

  The constructed materiality of African urbanism can be seen in buildings and the urban layout, especially when they aspire to permanence by building in stone. These built environments have mostly been ...

• The Violence Early-Warning System: Building a Scientific Foundation for Conflict Forecasting

  Research project from 2017-01-01 to 2021-12-31

  The challenges of preventing, mitigating, and adapting to large-scale political violence are daunting, particularly when violence escalates where it is not expected. Early-warning systems of sufficient ...

• The evolutionary and ecological implications of mito-nuclear epistasis

  Research project from 2015-10-01 to 2017-09-30

  The main hypothesis of the proposed research is that, contrary to common and long-standing belief, mitochondrial genetic variation is functional and plays a key role in evolutionary adaptation. I suggest ...

• Towards an Inclusive Common European Framework for Assisted Reproductive Technologies (ART): Queer Transgender Reproduction in the Age of ART.

  Research project from 2017-08-01 to 2019-07-31

  The use and regulation of Assisted Reproductive Technologies (ARTs) has undergone repeated significant changes since the 1980s, partly to accommodate biotechnological developments, partly to recognize ...

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