Research at Uppsala University
History of human antibiotic use written in the oral bacteria of wild brown bears
25 August 2021. An international team of researchers used historical museum collections to study the effects of huma ...
How research can encourage us to cycle instead
19 August 2021. How do you get to work in the mornings? Transport currently accounts for 25 per cent of GHG emission ...
Philippine ethnic group has most Denisovan DNA
13 August 2021. The Philippine ethnic group Ayta Magbukon has the highest proportion of genes from our extinct relat ...
Search for research projects
Here you will find all research projects at Uppsala University funded by the main Swedish funding bodies. The search feature is based on the SweCRIS database.
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Your choice produced 35 hits
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A novel food-based approach for preventing fatty liver disease and managing type 2 diabetes
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Research project from 2020-01-01 to 2022-12-31
Fatty liver is a common health disorder that precedes liver disease and predicts type 2 diabetes. Lipogenesis is the synthesis of fat from glucose in the liver. Dysregulation of this metabolic pathway ...
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Pancreatic islet vascular function; implications for the pathogenesis of type 2 diabetes.
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Research project from 2012-01-01 to 2014-12-31
The pancreatic islets are a complex micro-organ containing many cell types. The importance of interactions between these cells, particularly islet vasculature, for normal islet endocrine function has lately ...
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Role of fatty acids in ectopic fat accumulation and skeletal muscle hypertrophy during overfeeding: metabolic and molecular studies
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Research project from 2015-01-01 to 2017-12-31
Factors influencing body fat accumulation are poorly understood. Individuals that deposit fat in the liver, muscle and pancreas (ectopic fat) without increasing lean tissue (sarcopenic obesity) are prone ...
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Beyond GWAS of obesity: from genetic association to function
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Research project from 2016-01-01 to 2019-12-31
Over the next decades, dramatic increases of obesity and type 2 diabetes are expected in the U.S. and throughout the world. As insulin resistance is a usual intermediate step between obesity, type 2 diabetes ...
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CARE - Visualiserar fördelar med behandling mot hjärt- och kärlsjukdom, för ökad följsamhet med behandling för patienter med diabetes
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Research project from 2019-01-01 to 2022-12-31
Cardiovascular disease (CV) contributes greatly to high mortality and morbidity in diabetes and thus, treatment focuses on controlling risk factors, e.g. hypertension, hyperlipidemia and obesity. However ...
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Cardiovascular and metabolic disease in companion animals and their owners: A unique nationwide cohort study
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Research project from 2014-01-01 to 2016-12-31
This unique multi-disciplinary project will focus on the cardiovascular (CVD) and metabolic disease in companion animals and their owners by linking pet and human registries. Our planned research includes ...
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Cellular interventions and beta-cell replacement therapies in type 1 diabetes: a nationwide approach to develop the next generation therapies
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Research project from 2014-01-01 to 2017-12-31
This work aims to find strategies to prevent beta-cell death and restore beta-cell mass in Type 1 diabetes (T1D) in the absence of chronic immune suppression, i.e. to provide curative treatment. This project ...
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Collaboration and integrated digital solutions for improved diabetes care
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Research project from 2017-12-01 to 2020-12-31
Purpose and goal: Swedish diabetes care needs stronger collaboration between different actors as well as resource-efficient, pragmatic, clinical research on new treatment alternatives. We want to combine ...
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Developmental Origins of Health and Disease: Equitable Prevention Across Generations? Follow-up of the MINIMat Randomized Trial in Bangladesh
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Research project from 2013-01-01 to 2015-12-31
This project - follow-up of the MINIMat trial - is implemented in Bangladesh, in a context, where food insecurity and maternal malnutrition still prevail, but where changing lifestyles and economic growth ...
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Diabetes complications - causes and preventive treatment
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Research project from 2011-01-01 to 2016-12-31
Cardiovascular diseases are the most important complications of diabetes. Early identification and preventive treatment of persons at risk for diabetes complications are imperative. This research program ...
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Diabetes complications - causes and preventive treatment
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Research project from 2011-01-01 to 2016-12-31
Diabeteskomplikationer - orsaker och förebyggande behandling ...
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Early life exposures: the microbiome and type 1 diabetes
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Research project from 2016-01-01 to 2019-12-31
The incidence of type 1 diabetes has doubled in the last 30 years in Sweden, most likely because of a concomitant increase in one or several as yet unidentified environmental causes. The “hygiene hypothesis ...
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Elucidating the etiology of type I diabetes and development of cellular therapeutic interventions to halt or reverse the disease.
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Research project from 2015-01-01 to 2018-12-31
Type 1 diabetes (T1D) is in Sweden one of the most common chronic disorder in children, reaching more than 800 new patients per year (incidence doubled since 1990). Presently, diabetes can neither be prevented ...
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Elucidating the etiology of type I diabetes and development of therapeutic interventions to halt or reverse the disease.
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Research project from 2020-01-01 to 2023-12-31
Presently, Type 1 diabetes (T1D) can neither be prevented nor cured and is associated with devastating chronic complications.The overall objective of this research proposal is to understand the underlying ...
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Endocrine tumorigenesis
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Research project from 2012-01-01 to 2014-12-31
This project is a translational project with a twin focus: A/ adrenocortical carcinoma (ACC) and B/ pancreatic endocrine tumors. A/ We have run a phase III randomized, prospective, controlled, open -label ...
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Ethical and legal framework for the production of insulin in humans by using encapsulated hESC derived cells.
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Research project from 2017-01-01 to 2019-12-31
Ethical and legal issues arise at several levels in this project from the obtainment of embryos in association with IVF treatment to the development of therapy for diabetic patients on a large scale. The ...
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Improved diagnosis and potential treatment targets for primary aldosteronism, with special emphasis on the angiotensin II type 2-receptor.
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Research project from 2016-01-01 to 2018-12-31
Hypertension is one of the strongest risk factors for morbidity and mortality in cardiovascular diseases, and in most cases unknown - denoted primary hypertension. An estimated 5-15% of the affected individuals ...
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Genetic and environmental determinants of osteoporosis and osteoporotic fractures
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Research project from 2012-01-01 to 2015-12-31
Osteoporotic fractures are common in Sweden. We don?t know why. The significance of lifestyle, comorbidity and genetic constitution on the risk of osteoporotic fractures is going to be examined in a cohort ...
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The role of Glicentin in development of obesity-related type 2 diabetes
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Research project from 2013-12-01 to 2014-11-01
Currently not available ...
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How are sex, gender and health interwoven? Theoretical development in a Northern European context
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Research project from 2012-01-01 to 2015-12-31
While most feminist researchers today agree about the need to analyse both sex and gender there is a dearth of research on how sex and gender are interwoven. The purpose of this project is to develop theories ...
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The enigmatic alpha-cell - role in glucose homeostasis and diabetes.
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Research project from 2013-01-01 to 2013-12-31
Frisättningen av insulin och glukagon från de Langerhanska öarnas beta- respektive alfaceller är avgörande för blodsockerregleringen. Störd frisättning av insulin uppfattas idag som orsak till de flesta ...
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Kidney hypoxia and diabetic nephropathy
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Research project from 2014-01-01 to 2019-12-31
Kidney disease is a major cause for premature mortality in diabetic patients. The focus has recently shifted from a glomerulocentric to a predominantly tubulocentric view of mechanisms initiating the development ...
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Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) for studies of the obesity-diabetes-atherosclerosis disease process and its consequences
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Research project from 2013-01-01 to 2015-12-31
The main purpose of the project is to develop and validate MRI and PET methods for studies of the obesity-diabetes-atherosclerosis disease process and its consequences with a currently funded PET-MR equipment ...
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Means to monitor, preserve and restore beta-cell mass in type 1 diabetes mellitus
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Research project from 2013-01-01 to 2017-12-31
Possibilities to prevent pancreatic beta-cell death and restore beta-cell numbers are crucial for optimal treatment of type 1 diabetes (T1D). Moreover, non-invasive monitoring of beta-cell mass would be ...
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Metabolic and genetic response to moderate weight gain: role of dietary fat composition
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Research project from 2012-01-01 to 2014-12-31
Moderate overweight is common, but still are the metabolic implications of moderate weight gain poorly explored in humans. For unknown reasons, some individuals, but not others, deposit excess calories ...
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New tools in diagnostics of adrenocortical tumours
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Research project from 2012-01-01 to 2014-12-31
Essential hypertension is present in 20% of the Swedish population, and 10% of these presumably suffer from primary aldosteronism (PA). However, this ratio in Sweden is not fully known, why we are planning ...
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Nordic Symposium on Metabolic Disorders (NSMD) An interdisciplinary preclinical conference within metabolic disorders - From obesity and diabetes to development of atherosclerosis -
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Research project from 2011-07-01 to 2011-12-31
Today the metabolic syndrome is a global epidemic, driven in part by an increasing incidence of obesity in the society. A direct consequence of obesity and diabetes are major problems with the heart and ...
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PET imaging of the immune system in Type 1 Diabetes
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Research project from 2021-01-01 to 2024-12-31
The understanding of the autoimmune response in T1D is mainly based on animal models, human tissue biopsy or post-mortem analysis. However, pancreatic biopsies are invasive and dangerous and often not ...
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SGLT2 inhibitor or metformin as standard treatment in early type 2 diabetes (SMART)
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Research project from 2019-01-01 to 2021-12-31
In recent years, SGLT2 inhibitor(i) treatment on top of usual glucose-lowering therapy was reported to markedly lower the risk for premature death, cardiovascular and renal complications in type 2 diabetes ...
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Signal transduction of pancreatic islet hormone secretion
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Research project from 2013-01-01 to 2015-12-31
The specific objectives of the present studies are to clarify signal transduction pathways underlying pulsatile secretion insulin from beta cells and glucagon from alpha cells in the islets of Langerhans ...
Showing 30 Of 35 hits
Show more hitsResearch spotlight: The coronavirus
New method for discovery of antiviral drugs
2 August 2021. The current COVID-19 pandemic has highlighted the need for methods to identify new or repurposed dru ...
Helpline important for older people during the pandemic
8 July 2021. For many older individuals, the COVID-19 pandemic has resulted in the loss of daily anonymous contac ...
The national COVID-19 Data Portal turns one year old
3 June 2021. The national Swedish COVID-19 Data Portal was launched one year ago to support researchers in utilis ...
Lectures
Uppsala University’s researchers share their knowledge in public lectures. Every year, the University is visited by leading researchers and influential people from around the world. At Uppsala University, you can hear Nobel laureates, researchers, authors, politicians and many others give lectures. Here we present some of the most prominent, annually occurring lectures at Uppsala University.