Research at Uppsala University
History of human antibiotic use written in the oral bacteria of wild brown bears
25 August 2021. An international team of researchers used historical museum collections to study the effects of huma ...
How research can encourage us to cycle instead
19 August 2021. How do you get to work in the mornings? Transport currently accounts for 25 per cent of GHG emission ...
Philippine ethnic group has most Denisovan DNA
13 August 2021. The Philippine ethnic group Ayta Magbukon has the highest proportion of genes from our extinct relat ...
Search for research projects
Here you will find all research projects at Uppsala University funded by the main Swedish funding bodies. The search feature is based on the SweCRIS database.
Selected filters:
Search results
Your choice produced 57 hits
-
Antibiotic induced persistence in Mycobacterium tuberculosis
...
Research project from 2014-01-01 to 2016-12-31
Drug-resistant Mycobacterium tuberculosis, the causative agent of tuberculosis, poses a significant threat to global health. It is proposed that persister cells are important for development of drug resistance ...
-
Antibiotics and antibiotic resistance in waste water: implications for selection and transmission of multi-resistance plasmids at very low antibiotic concentrations.
...
Research project from 2017-01-01 to 2019-12-31
Antibiotics isthe most important group of medicines created by man. They have dramatically reduced the morbidity and mortality caused by bacterial infectious disease. Our modern medicine is dependent uponthe ...
-
Antimicrobial resistance in the environment and human health impact
...
Research project from 2017-01-01 to 2020-12-31
Antimicrobial resistance is a rapidly growing health concern but environmental aspects are largely understudied. Here, a 2017-2020 multi-disciplinary project is proposed in which development and transfer ...
-
Arrested infection: probing intermediates in viral entry with cell mimetics
...
Research project from 2018-01-01 to 2021-12-31
Enveloped viruses such as influenza, HIV, and Zika enter cells via a process of membrane fusion between the viral envelope and a cellular membrane, mediated by viral fusion proteins. The non-protein components ...
-
Campylobacter - a major waterborne zoonotic enteropathogen
...
Research project from 2013-01-01 to 2015-12-31
Campylobacter is the most common gastrointestinal bacterial pathogen and the most commonly reported zoonosis in the European Union. Although Campylobacter causes significant economic and disease burden ...
-
Campylobacter in organic broiler production and transmission to humans
...
Research project from 2017-01-01 to 2019-12-31
Campylobacteriosis is the most common zoonosis in large parts of the world and poultry is the major source of infection. Organic broiler production is rapidly increasing in Sweden, but due to the free ...
-
Campylobacter infections - connecting bacterial pathogenicity mechanisms to human disease outcome
...
Research project from 2012-01-01 to 2014-12-31
Campylobacter is the most common cause of bacterial gastroenteritis in the western world, estimated to cause several million infections annually in the EU. Campylobacter infections burden the Swedish society ...
-
Cell morphology and stress in mycobacteria
...
Research project from 2013-01-01 to 2015-12-31
Mycobacteria inhabit various environmental reservoirs, e.g. ground and tap water, soil, animals and humans. Many mycobacteria are also highly successful pathogens, e.g. M. bovis and M. avium subsp paratuberculosis ...
-
The Cell Biology of Enteric Bacterial Infection - from HeLa Cells to the in vivo Niche
...
Research project from 2016-01-01 to 2018-12-31
Bacterial infections are re-emerging as a serious health threat, caused by the rampant spread of resistance mechanisms towards clinically relevant antibiotics. Intestinal pathogens of the family enterobacteriaceae ...
-
China-Sweden joint investigation on zoonotic pathogens in a changing environment
...
Research project from 2018-01-01 to 2020-12-31
The life cycles and transmission of many infectious agents are inextricably tied to the environment. Environmental changes can cause profound and often complex influence on the prevalence or severity of ...
-
Combination effects of antibacterial substances in sewage water – How does the combination of antibiotics and other antibacterial substances affect selection and spread of antibiotic resistance?
...
Research project from 2020-01-01 to 2022-12-31
Antibiotics is the most important group of medicines. They have dramatically reduced the morbidity and mortality caused by bacterial infections. Our modern medicine is dependent upon the possibility to ...
-
Comparative genomics of domestic animals and wild host populations for studies of virus-host co-evolution
...
Research project from 2019-01-01 to 2021-12-31
The purpose of this project is to generate new knowledge about co-evolution among retroviruses and their hosts by studying natural variation in the endogenous retrovirus (ERV) record within and across ...
-
Comparative genomics of host populations for studies of virus-host co-evolution
...
Research project from 2019-01-01 to 2021-12-31
The purpose of this project is to generate new knowledge about co-evolution among retroviruses and their hosts by studying natural variation in the endogenous retrovirus (ERV) record within and across ...
-
Developing combinations of CO-ACTIVE antimicrobials and non-antimicrobials
...
Research project from 2015-12-01 to 2018-11-30
The CO-ACTION project aims to develop and provide a framework for evaluating and validating the effectiveness of antibiotic (AB)- and non-antibiotic (NA) combinations (COMs) in the preclinical setting ...
-
Developing combinations of CO-ACTIVE antimicrobials and non-antimicrobials
...
Research project from 2015-12-01 to 2018-11-30
The CO-ACTION project aims to develop and provide a framework for evaluating and validating the effectiveness of antibiotic (AB)- and non-antibiotic (NA) combinations (COMs) in the preclinical setting ...
-
Dynamics of gene regulatory networks in response to different stresses in Mycobacteria
...
Research project from 2018-01-01 to 2020-12-31
Gene regulatory networks play important roles in e.g. the cell cycle, signal transduction, cellular differentiation, and adaptation to varying environments. Understanding the dynamics of these networks ...
-
Effects of genetic context, environmental conditions and microbiome composition on the evolution of antibiotic resistance: a comprehensive systems-biology approach to a major health problem
...
Research project from 2019-07-01 to 2022-06-30
Antibiotic resistance evolution is typically studied under highly controlled conditions. However, various observations suggest, that the phenotypic penetrance of resistance genes depends on the strain ...
-
Evolution of resistance to antimicrobial drugs
...
Research project from 2013-01-01 to 2017-12-31
The world-wide rapid increase in antibiotic resistance represents a major health, societal and scientific challenge, and if continued unabated might result in a post-antibiotic era where our most important ...
-
Evolutionary profiling of emerging influenza viruses
...
Research project from 2016-01-01 to 2019-12-31
Influenza A viruses (IAV) pose a major threat to the health and well-being of both human and animal populations, despite the availability of vaccines and antivirals. One of the biggest challenges is the ...
-
Evolutionary trajectories to antibiotic resistance
...
Research project from 2013-01-01 to 2017-12-31
Resistance to antibiotics is associated with mutations or genes that increase MIC in vitro, but usually at the cost of reduced fitness. Compensatory evolution to ameliorate fitness costs of resistance ...
-
From friend to foe: tracing the emergence of host adaptation and pathogenicity in the bacterial order Legionellales
...
Research project from 2018-01-01 to 2021-12-31
The goal of this project is to better understand the precise molecular mechanisms underlying long- and short-term evolution of host adaptation in intracellular bacteria and to identify critical genetic ...
-
Inhibition of antimicrobial drug resistance: Exploiting an old drug as a basis for inhibitory discovery
...
Research project from 2016-11-01 to 2017-12-31
The alarming increase in the numbers of infections by multidrug-resistant Gramnegativepathogens in the EU calls for new strategies and solutions to addressbacterial resistance mechanisms. In response to ...
-
redicting, preventing and diagnosing antibiotic resistance
...
Research project from 2009-07-01 to 2014-06-30
Currently not available ...
-
Modulation of Antibiotic Resistance by Genetic Context and Environment
...
Research project from 2018-01-01 to 2021-12-31
It is generally assumed that an acquired antibiotic resistance mechanism results in a predictable increase in phenotypic resistance irrespective of bacterial growth conditions or the genetic context. However ...
-
Virulence plasmid copy number control: a newly identified regulatory tactic of pathogenic bacteria
...
Research project from 2019-01-01 to 2022-12-31
Recently, we reported a novel strategy of Yersinia pseudotuberculosis whereby this human pathogen up-regulates the copy number of its virulence plasmid during infection – a process that is indispensable ...
-
Giardia- from stolen virulence genes to new drugs.
...
Research project from 2020-12-01 to 2022-12-31
The intestinal parasite Giardia intestinalis is the most common intestinal protozoan infection in humans with more than 180 million symptomatic cases and almost 0.5 billion asymptomatic infections yearly ...
-
Human intestinal protozoa: friends or foes?
...
Research project from 2018-01-01 to 2020-12-31
We will study the molecular mechanisms behind disease-induction and immunomodulation by intestinal protozoa. We will mainly focus on the intestinal protozoan parasite Giardia intestinalis that can cause ...
-
The role of bacterial contact-dependent growth inhibition in bacteria-host interactions
...
Research project from 2020-01-01 to 2023-12-31
Our understanding of bacterial infections have never been more important than now, when effective antibiotics are scarce and common bacterial infections are once again becoming lethal. Contact-dependent ...
-
INFECTION BIOLOGY IN FISH: UNDERSTANDING SPIRONUCLEUS INFECTIONS OF SALMONIDS
...
Research project from 2013-11-12 to 2016-12-31
The fastest growing food sector in the world is aquaculture, with salmon and carp being the two most important fish species used in fish farming. Infections are well-known problems in fish farming, involving ...
-
Non-coding and regulatory RNAs in mycobacteria
...
Research project from 2017-01-01 to 2020-12-31
To face the medical challenge mycobacterial infections, such as tuberculosis, impose on healthcare systems worldwide we need to understand and identify factors important for mycobacterial pathogenicity ...
Showing 30 Of 57 hits
Show more hitsResearch spotlight: The coronavirus
New method for discovery of antiviral drugs
2 August 2021. The current COVID-19 pandemic has highlighted the need for methods to identify new or repurposed dru ...
Helpline important for older people during the pandemic
8 July 2021. For many older individuals, the COVID-19 pandemic has resulted in the loss of daily anonymous contac ...
The national COVID-19 Data Portal turns one year old
3 June 2021. The national Swedish COVID-19 Data Portal was launched one year ago to support researchers in utilis ...
Lectures
Uppsala University’s researchers share their knowledge in public lectures. Every year, the University is visited by leading researchers and influential people from around the world. At Uppsala University, you can hear Nobel laureates, researchers, authors, politicians and many others give lectures. Here we present some of the most prominent, annually occurring lectures at Uppsala University.