Forskning vid Institutionen för Farmaceutisk biovetenskap
Utveckling av framtidens läkemedel
Vår forskning omfattar allt från grundläggande frågor om hur läkemedel påverkar den levande cellen och hur de omsätts i kroppen, till sökande efter nya modeller för att beskriva läkemedels effekter. Det övergripande målet för institutionens forskargrupper är att förbättra kunskapen om läkemedels upptag, farmakokinetik, metabolism, effekter och biverkningar.
Vi lägger stor vikt vid samarbete med det omgivande samhället, och forskningsprojekten bedrivs ofta i nära samverkan med nationella och internationella laboratorier och läkemedelsindustrier. Forskningssamarbete med internationell läkemedelsindustri och med övriga delar av hälso- och sjukvårdsområdet borgar för en hög kvalitet. Vi har även en omfattande forskarutbildning inom de olika forskargrupperna.

Forskargrupper
Anders Backlund | Farmakognosi |
Hanna Karlsson | Toxikologi |
Christian Benedict | Farmakologi sömnforskning |
Erik Jansson | Medicinsk masspektrometri |
Albert Mihranyan | Läkemedelsteknik |
Göran Frenning | Farmaceutisk fysik |
Hans Lennernäs | Translationell Läkemedelsutveckling |
Johan Lennartsson | Farmaceutisk cellbiologi och bioteknologi |
Maria Norlin | Steroidbiokemi |
Mathias Hallberg | Biologisk beroendeforskning |
Ola Spjuth | Farmaceutisk bioinformatik |
Ola Söderberg | Farmaceutisk cellbiologi |
Per Andrén | Medicinsk masspektrometri |
Robert Fredriksson | Molekylär Neurofarmakologi |
Ulf Göransson | Farmakognosi |
Forskningsområde
Hanna Karlsson | Läkemedelssäkerhet och toxikologi |
Albert Mihranyan | Läkemedelsteknik |
Göran Frenning | Farmaceutisk fysik |
Hans Lennernäs | Biofarmaci |
Mathias Hallberg | Neurofarmakologi och biologisk beroendeforskning |
Ola Spjuth | Farmaceutisk bioinformatik |
Ola Söderberg | Farmaceutisk cellbiologi |
Per Andrén | Avbildande masspektrometri |
Robert Fredriksson | Farmakologi |
Ulf Göransson | Farmakognosi |
Våra bidragsgivare
AbbVie Inc |
Akademiska sjukhuset |
Astra Zeneca |
Barncancerfonden |
Bergvalls stiftelse |
Cancerfonden |
Dicot AB |
EU-komm, Horizon (H2020) |
EU-komm, Horizon Europe |
EU-komm, övriga EU-medel |
Faciasstiftelsen |
FORMAS |
Galderma |
Gc Biopharma |
Gustavianska stiftelsen (RF) |
Hiertas Minne |
Hjärnfonden |
Kammarkollegiet |
Karolinska institutet |
Kjell och Märta Beijers Stiftelse |
Kungliga tekniska högskolan |
NovoNordiskfonden |
Sagens stiftelse |
SIDA-Styrelsen för internationellt utvecklingssamarbete |
Socialstyrelsen |
Stift för strategisk forskning |
STINT |
Svenska spel AB |
Sveriges lantbruksuniversitet |
Umeå universitet |
Uppsala Akademiförvaltning |
Vetenskapsrådet |
VINNOVA |
Åhlénstiftelsen |
Åke Wibergs stiftelse |
Publikationer
Aktuella publikationer
- Column coupling for chiral LC-MS separation resolves triacylglycerol enantiomers and regioisomers in complex samples without flow recyclingNilsson, Jenny M.; Balgoma, David; Stephansson, Edvin Dedering et al., 2027
- A morphology-based machine learning model for scoring epithelial-mesenchymal plasticity using organelle dynamicsSlager, Justin; Gatto, Francesca; Frey, Benjamin et al., 2026
- The long noncoding RNA VIM-AS1 and nucleoporin Nup358/RanBP2 regulate SMAD nuclear accumulation during TGF-β signalingMendes Rodrigues Junior, Dorival; Ali, Mohamad Moustafa; Itoh, Yuka et al., 2026
- From material properties to aerosolisation propensity of adhesive mixtures for inhalation: On consecutive relationships between drug load, blend state and blend performanceSimonsson, Anna, 2026
- The time dimension matters: Improving mode of action classification with live-cell imagingForsgren, Edvin; Rietdijk, Jonne; Holmberg, David et al., 2026
- In situ mapping of activated PDGFRβ defines a prognostic discrepancy between histological subtypes of NSCLCLindberg, Amanda; Hellberg, Louise; Grandon, Anaïs et al., 2026
- 24-Hydroxycholesterol suppresses steroid 5α-reductase-catalyzed conversion in human glioblastoma cell lines: A novel link between brain cholesterol homeostasis and androgen metabolismWikvall, Kjell; Olsson, Frida; Wåhlén, Erik et al., 2026
- Conserved NT5C2 links context-specific behaviors with psychiatric and metabolic riskMoulin, Thiago; Aldavero-Munoz, Ivan; Williams, Michael J. et al., 2026
- Farnesol, a Dietary Sesquiterpene, Attenuates Rotenone-Induced Dopaminergic Neurodegeneration by Inhibiting Oxidative Stress, Inflammation, and Apoptosis via Mediation of Cell Signaling Pathways in RatsEddin, Lujain Bader; Arunachalam, Seenipandi; Azimullah, Sheikh et al., 2026
- Development and Application of Computational Methods in Mass Spectrometry ImagingBjärterot, Patrik, 2026
- CDK2 inhibition promotes neuronal differentiation in neuroblastomaAlzrigat, Mohammad; Mahmoud, Loay; Topcu, Ada Nursel et al., 2026
- Open Systems Pharmacology Community Conference (OSP-CC) Proceedings 2025Cordes, Henrik; Annaert, Pieter; Balazki, Pavel et al., 2026
- Single-dose DMT reverses anhedonia and cognitive deficits via restoration of neurogenesis in a stress-induced depression modelLima da Cruz, Rafael V.; Costa, Remullo B. G. de Miranda; de Queiroz, Gabriel M. et al., 2026
- α-Helical Peptides Encoded in Collagen Exhibit Antimicrobial Activity with Low CytotoxicityJarmusch, Scott A.; Muhammad, Taj; Göransson, Ulf et al., 2026
- Co-exposure to PFAS and hydroxylated PCBs is associated with increased odds of multiple sclerosisVaivade, Aina; Parakkal Sreenivasan, Akshai; Erngren, Ida et al., 2026
- Revival of Ethionamide by AlpibectirPieren, Michel; Dale, Glenn E.; Gitzinger, Marc et al., 2026
- Alanine Mutagenesis Identifies Specific Amino Acids of Nemertide Alpha-1 Activity and Its Binding yo Target ReceptorsLaborde, Quentin; Peigneur, Steve; Jacobsson, Erik et al., 2026
- Different metabolic pathways associated with total cortisol exposure and the cortisol time profile: a randomized crossover trialMcQueen, Johanna; Garner, Terence; Chantzichristos, Dimitrios et al., 2026
- Chemical richness and diversity of uncultivated 'Entotheonella' symbionts in marine spongesDell, Maria; Kogawa, Masato; Streiff, Alena B. et al., 2026
- From consequences of sleep loss to interventionsMeth, Elisa, 2026
- Structural analyses of oxygen channels of animal, soybean and manganese lipoxygenasesOliw, Ernst H., 2026
- Spatial lipidomics identifies α-synuclein-induced lipid changes in an AAV-induced Parkinsonian mouse modelHe, Yachao; Kaya, Ibrahim; Zhang, Xiaoqun et al., 2026
- Time to Regularize Sleep RegularityCedernaes, Jonathan; Sielaff, Bettina; Benedict, Christian, 2026
- Semaglutide Prevents Aortic Rupture and Dissection in the Angiotensin II Mouse ModelBalboa Ramilo, Amanda; Mani, Kevin; Wanhainen, Anders et al., 2026
- Higher Daytime Light Exposure Predicts Lower Risk of Gastrointestinal Cancer Incidence and Mortality.Mei, Xionge; Wang, Wei; Zheng, Nana et al., 2026
- Pleiotropic effects of BET inhibition broadly boost tumor immunogenicity to CD8+ T cellsMelief, Jeroen; Baldran-Groves, Lucas; Gerault, Marc-Antoine et al., 2026
- Effects of a joint outdoor exercise program for dog owners and dogs on physical activity, sedentary time and sleep-related behaviorsSmedberg, Klara; Bergh, Anna; Roman, Erika et al., 2026
- The C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migrationPunga, Tanel; Larsson, Mårten; Mujica, Endrina et al., 2026
- G3BP1 is a SWI/SNF-bound regulator of transcription that modulates activation of STATsPapadopoulos, Natalia; Sarri, Niki; Lennartsson, Johan et al., 2026
- Bioactivity-guided isolation of anti-inflammatory compounds from the herbs constituting a traditional Chinese medicine formulation used for the treatment of rheumatoid arthritisWelzel, Janika; Robertson, Luke; Brieskorn, Louisa et al., 2026
- Meta-analysis of blood metabolomics reveals dysregulated amino acid, neurotransmitter, and energy pathways in depressionPanina, Aleksandra; Sokolov, Aleksandr V.; Khandokhin, Mikhail M. et al., 2026
- Slc6a9 is distributed in glial cells and neurons across several nervous system regions, whereas Slc6a5 is more restricted to neurons in the caudal brainCeder, Mikaela M.; Lagerström, Malin C., 2026
- Spatial lipidomic and neuron-specific transcriptomic signatures in the nucleus accumbens reveal phospholipid dyshomeostasis in depression-related maladaptationsCamargo, Anderson; Kaya, Ibrahim; Sturchio, Andrea et al., 2026
- Population pharmacokinetics of TBAJ-587 and its main metabolites-Evaluation of different loading dose strategies and early dose selectionLeding, Albin A.M.; Bruinenberg, Paul; Conradie, Almari et al., 2026
- Formulation breakthroughs driving broader tyrosine kinase useLennernäs, Hans; Jesson, Gerald; Liljebris, Charlotta et al., 2026
- Association of Prodromal Parkinson's Disease‐Like Features in Long COVID With Dream‐Enactment BehavioursGong, Siyi; Liu, Yaping; Huang, Bei et al., 2026
- Opposing effects of Rho-associated coiled-coil kinase 1 (ROCK1) and ROCK2 on TGF-β-SMAD signalingBai, Yu; Ali, Mohamad Moustafa; van Dinther, Maarten et al., 2026
- Counting cells can accurately predict small-molecule bioactivity benchmarksSeal, Srijit; Dee, William; Shah, Adit et al., 2026
- Understanding biology with machine learning: compression, intelligibility, and dependencyLawrence, Elsa; El-Shazly, Adham; Seal, Srijit et al., 2026
- Classification of industrial chemicals for respiratory chemosensory irritation using the TRPV1-expressing neuronal SH-SY5Y cell model and machine learningHinojosa, Maria; Johanson, Gunnar; Norinder, Ulf et al., 2026
- Rational formulation design through retrospective machine learning methodology: Case study ibuprofenGaramani, Dylan; Sjögren, Erik; Mihranyan, Albert, 2026
- Transcriptomic Profiling of Toxic Copper Overload Induced by CuO Nanoparticles or Copper Ions in Human Lung Epithelial and Liver CellsKuhn, Jana; Gliga, Anda R.; Aissouni, Cheyenne Ines et al., 2026
- "Controlled by Female Hormones": A Qualitative Interview Study of Swedish Women's Experiences of Gender-Specific Aspects of Life With ADHDMcTaggart, Julia; Thorell, Lisa B.; Skoglund, Charlotte et al., 2026
- Effect of amino acids on the compaction behavior and stability of spray-dried trypsin/lactose powderZhang, Chengqian; Frenning, Göran; Van De Weert, Marco et al., 2026
- Analytical Centrifugal Ultrafiltration as a Tool for High Throughput Process Development in Virus Removal FiltrationMaffeis, Sebastien; Fomichova, Yuliia; Manukyan, Levon et al., 2026
- Rules for Dibenzocyclooctadiene Conformational DynamicsRobertson, Luke; Xu, Wen; Brieskorn, Louisa et al., 2026
- Thiol-reactive compound depletion reveals electrophile-dependent and independent anti-inflammatory constituents in Saussurea costusWelzel, Janika; Boddul, Sanjaykumar; Robertson, Luke et al., 2026
- Integrative transcriptomic meta-analysis reveals immune, synaptic, and non-coding RNA dysregulation in bipolar disorder across brain and bloodPanina, Aleksandra; Sokolov, Aleksandr V.; Jonsson, Jörgen et al., 2026
- The hypothalamic vasopressin circuit drives lateralized endocrine signalingBakalkin, Georgy; Watanabe, Hiroyuki; Kobikov, Yaromir et al., 2026
- Increased p-Tau181 Levels After Overnight Wakefulness Are Associated With Neuroticism in Young WomenNoga Morais Ferreira, Diana; Meth, Elisa; Almajni, Abdullah et al., 2026