Farmakognosi

Beskrivning
Forskning och undervisning inom ämnet Farmakognosi är inriktad på biologiskt aktiva substanser av naturligt ursprung.
Förutom möjligheten att upptäcka nya läkemedelskandidater för läkemedelsutveckling har bioaktiva naturliga projekt potential som farmakologiska verktyg, mellanprodukter eller mallar för syntes av läkemedel. Som en tvärvetenskaplig division bedriver vi omfattande nationella och internationella forskningssamarbeten i t.ex. klinisk farmakologi, marin kemisk ekologi, systematisk botanik och strukturell biologi.
Vår forskning representerar en modernisering och förnyelse av en värdig beprövad vetenskap, Farmakognosi. Med dagens ökade intresse för miljöaspekter, grön kemi och en hållbar användning av naturprodukter kan denna förnyelse ha en strategisk position i brokemi och biologi.
De pågående projekten är inriktade på kemi och biologi av ultrastabila proteiner, metoder för urval och målsökning, antifouling och antibakteriella molekyler från marina organismer (svampar, nemertiner), antiinflammatorisk och antitumöraktivitet hos naturliga produkter.
Publikationer
Ingår i Plants, 2025
- DOI för Interpopulational Variation in Cyclotide Production in Heavy-Metal-Treated Pseudometallophyte (Viola tricolor L.)
- Ladda ner fulltext (pdf) av Interpopulational Variation in Cyclotide Production in Heavy-Metal-Treated Pseudometallophyte (Viola tricolor L.)
The involvement of cyclotides in the heavy metal tolerance of Viola spp.
Ingår i Scientific Reports, 2024
- DOI för The involvement of cyclotides in the heavy metal tolerance of Viola spp.
- Ladda ner fulltext (pdf) av The involvement of cyclotides in the heavy metal tolerance of Viola spp.
Ingår i Toxins, 2024
- DOI för Peptide toxins from the Antarctica: The Nemertean Predator and Scavenger Parborlasia corrugatus (McIntosh, 1876)
- Ladda ner fulltext (pdf) av Peptide toxins from the Antarctica: The Nemertean Predator and Scavenger Parborlasia corrugatus (McIntosh, 1876)
Kalata B1 Enhances Temozolomide Toxicity to Glioblastoma Cells
Ingår i Biomedicines, 2024
- DOI för Kalata B1 Enhances Temozolomide Toxicity to Glioblastoma Cells
- Ladda ner fulltext (pdf) av Kalata B1 Enhances Temozolomide Toxicity to Glioblastoma Cells
Ingår i PLOS ONE, 2024
- DOI för Screening for antibacterial and cytotoxic activities of Sri Lankan marine sponges through microfractionation: Isolation of bromopyrrole alkaloids from Stylissa massa
- Ladda ner fulltext (pdf) av Screening for antibacterial and cytotoxic activities of Sri Lankan marine sponges through microfractionation: Isolation of bromopyrrole alkaloids from Stylissa massa
Ingår i Journal of Natural Products, s. 52-65, 2023
- DOI för Screening for Cyclotides in Sri Lankan Medicinal Plants: Discovery, Characterization, and Bioactivity Screening of Cyclotides from Geophila repens
- Ladda ner fulltext (pdf) av Screening for Cyclotides in Sri Lankan Medicinal Plants: Discovery, Characterization, and Bioactivity Screening of Cyclotides from Geophila repens
Ingår i Fitoterapia, 2023
- DOI för Antibacterial eremophilane sesquiterpenoids from Xylaria feejeensis, an endophytic fungi of the medicinal plant Geophila repens
- Ladda ner fulltext (pdf) av Antibacterial eremophilane sesquiterpenoids from Xylaria feejeensis, an endophytic fungi of the medicinal plant Geophila repens
On the structures of the penduflorines from Tabernaemontana penduliflora
Ingår i Fitoterapia, 2023
- DOI för On the structures of the penduflorines from Tabernaemontana penduliflora
- Ladda ner fulltext (pdf) av On the structures of the penduflorines from Tabernaemontana penduliflora
Ingår i ACS Applied Materials and Interfaces, s. 24186-24196, 2023
Ingår i ACS Omega, s. 37116-37127, 2023
- DOI för Anti-inflammatory and Antiphytopathogenic Fungal Activity of 2,3-seco-Tirucallane Triterpenoids Meliadubins A and B from Melia dubia Cav. Barks with ChemGPS-NP and In Silico Prediction
- Ladda ner fulltext (pdf) av Anti-inflammatory and Antiphytopathogenic Fungal Activity of 2,3-seco-Tirucallane Triterpenoids Meliadubins A and B from Melia dubia Cav. Barks with ChemGPS-NP and In Silico Prediction
A Synthetic Cyclized Antimicrobial Peptide with Potent Effects against Drug-Resistant Skin Pathogens
Ingår i ACS - Infectious Diseases, s. 1056-1063, 2023
- DOI för A Synthetic Cyclized Antimicrobial Peptide with Potent Effects against Drug-Resistant Skin Pathogens
- Ladda ner fulltext (pdf) av A Synthetic Cyclized Antimicrobial Peptide with Potent Effects against Drug-Resistant Skin Pathogens
Ingår i Journal of Natural Products, s. 566-573, 2023
- DOI för Exploring the limits of cyanobactin macrocyclase PatGmac: Cyclization of PawS-derived peptide sunflower trypsin inhibitor-1 and cyclotide kalata B1
- Ladda ner fulltext (pdf) av Exploring the limits of cyanobactin macrocyclase PatGmac: Cyclization of PawS-derived peptide sunflower trypsin inhibitor-1 and cyclotide kalata B1
Epitopes displayed in a cyclic peptide scaffold bind SARS-CoV-2 antibodies
Ingår i ChemBioChem, 2023
- DOI för Epitopes displayed in a cyclic peptide scaffold bind SARS-CoV-2 antibodies
- Ladda ner fulltext (pdf) av Epitopes displayed in a cyclic peptide scaffold bind SARS-CoV-2 antibodies
Differential Blood-Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro
Ingår i Pharmaceutics, 2023
- DOI för Differential Blood-Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro
- Ladda ner fulltext (pdf) av Differential Blood-Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro
Transforming Cross-Linked Cyclic Dimers of KR-12 into Stable and Potent Antimicrobial Drug Leads
Ingår i Biomedicines, 2023
- DOI för Transforming Cross-Linked Cyclic Dimers of KR-12 into Stable and Potent Antimicrobial Drug Leads
- Ladda ner fulltext (pdf) av Transforming Cross-Linked Cyclic Dimers of KR-12 into Stable and Potent Antimicrobial Drug Leads
Ingår i Cellular and Molecular Life Sciences (CMLS), 2022
- DOI för A stable cyclized antimicrobial peptide derived from LL-37 with host immunomodulatory effects and activity against uropathogens
- Ladda ner fulltext (pdf) av A stable cyclized antimicrobial peptide derived from LL-37 with host immunomodulatory effects and activity against uropathogens
Ingår i Journal of Natural Products, s. 215-224, 2022
- DOI för Spatial Distribution and Stability of Cholinesterase Inhibitory Protoberberine Alkaloids from Papaver setiferum
- Ladda ner fulltext (pdf) av Spatial Distribution and Stability of Cholinesterase Inhibitory Protoberberine Alkaloids from Papaver setiferum
Ingår i PLOS ONE, 2022
- DOI för In vitro and in silico evaluation of Ononis isoflavonoids as molecules targeting the central nervous system
- Ladda ner fulltext (pdf) av In vitro and in silico evaluation of Ononis isoflavonoids as molecules targeting the central nervous system
The involvement of cyclotides in mutual interactions of violets and the two-spotted spider mite
Ingår i Scientific Reports, 2022
- DOI för The involvement of cyclotides in mutual interactions of violets and the two-spotted spider mite
- Ladda ner fulltext (pdf) av The involvement of cyclotides in mutual interactions of violets and the two-spotted spider mite
Ingår i Pharmaceutics, 2022
- DOI för Stability Study of Alpinia galanga Constituents and Investigation of Their Membrane Permeability by ChemGPS-NP and the Parallel Artificial Membrane Permeability Assay
- Ladda ner fulltext (pdf) av Stability Study of Alpinia galanga Constituents and Investigation of Their Membrane Permeability by ChemGPS-NP and the Parallel Artificial Membrane Permeability Assay
Ingår i PLANTS, 2022
- DOI för The Influence of Plant Stress Hormones and Biotic Elicitors on Cyclotide Production in Viola uliginosa Cell Suspension Cultures
- Ladda ner fulltext (pdf) av The Influence of Plant Stress Hormones and Biotic Elicitors on Cyclotide Production in Viola uliginosa Cell Suspension Cultures
Where traditional Chinese medicine meets Western medicine in the prevention of rheumatoid arthritis
Ingår i Journal of Internal Medicine, s. 745-763, 2022
- DOI för Where traditional Chinese medicine meets Western medicine in the prevention of rheumatoid arthritis
- Ladda ner fulltext (pdf) av Where traditional Chinese medicine meets Western medicine in the prevention of rheumatoid arthritis
Cyclotide host-defense tailored for species and environments in violets from the Canary Islands
Ingår i Scientific Reports, 2021
- DOI för Cyclotide host-defense tailored for species and environments in violets from the Canary Islands
- Ladda ner fulltext (pdf) av Cyclotide host-defense tailored for species and environments in violets from the Canary Islands
Ingår i PLOS ONE, 2021
- DOI för Survival and growth of saprotrophic and mycorrhizal fungi in recalcitrant amine, amide and ammonium containing media
- Ladda ner fulltext (pdf) av Survival and growth of saprotrophic and mycorrhizal fungi in recalcitrant amine, amide and ammonium containing media
Ingår i Journal of Agricultural and Food Chemistry, s. 11856-11866, 2021
Functional characterization of the nemertide alpha family of peptide toxins
Ingår i Journal of Natural Products, s. 2121-2128, 2021
Barrettides: A Peptide Family Specifically Produced by the Deep-Sea Sponge Geodia barretti
Ingår i Journal of Natural Products, s. 3138-3146, 2021
- DOI för Barrettides: A Peptide Family Specifically Produced by the Deep-Sea Sponge Geodia barretti
- Ladda ner fulltext (pdf) av Barrettides: A Peptide Family Specifically Produced by the Deep-Sea Sponge Geodia barretti
Ingår i Phytochemistry, 2021
- DOI för Tropical vibes from Sri Lanka - cyclotides from Viola betonicifolia by transcriptome and mass spectrometry analysis
- Ladda ner fulltext (pdf) av Tropical vibes from Sri Lanka - cyclotides from Viola betonicifolia by transcriptome and mass spectrometry analysis
Antimicrobial and antioxidant activity of Evernia prunastri extracts and their isolates
Ingår i World Journal of Microbiology & Biotechnology, 2021
- DOI för Antimicrobial and antioxidant activity of Evernia prunastri extracts and their isolates
- Ladda ner fulltext (pdf) av Antimicrobial and antioxidant activity of Evernia prunastri extracts and their isolates
Ingår i RSC CHEMICAL BIOLOGY, s. 1682-1691, 2021
- DOI för Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides
- Ladda ner fulltext (pdf) av Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides
Exploring natural products-based cancer therapeutics derived from egyptian flora
Ingår i Journal of Ethnopharmacology, 2021
Ingår i Frontiers in Pharmacology, 2021
- DOI för Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses
- Ladda ner fulltext (pdf) av Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses
Editorial: Natural Antimicrobial Peptides: Hope for New Antibiotic Lead Molecules
Ingår i Frontiers in Pharmacology, 2021
- DOI för Editorial: Natural Antimicrobial Peptides: Hope for New Antibiotic Lead Molecules
- Ladda ner fulltext (pdf) av Editorial: Natural Antimicrobial Peptides: Hope for New Antibiotic Lead Molecules
Ingår i Biochemistry and Biophysics Reports, 2021
- DOI för Antioxidant properties and phenolic profiling by UPLC-QTOF-MS of Ajwah, Safawy and Sukkari cultivars of date palm
- Ladda ner fulltext (pdf) av Antioxidant properties and phenolic profiling by UPLC-QTOF-MS of Ajwah, Safawy and Sukkari cultivars of date palm
Recent insights into chemical and pharmacological studies of bee bread
Ingår i Trends in Food Science & Technology, s. 300-316, 2020
Sulfadiazine Masquerading as a Natural Product from Scilla madeirensis (Scilloideae)
Ingår i Journal of Natural Products, s. 1305-1308, 2020
- DOI för Sulfadiazine Masquerading as a Natural Product from Scilla madeirensis (Scilloideae)
- Ladda ner fulltext (pdf) av Sulfadiazine Masquerading as a Natural Product from Scilla madeirensis (Scilloideae)
Ingår i Journal of Systematics and Evolution, s. 103-117, 2020
The life cycle of cyclotides: biosynthesis and turnover in plant cells
Ingår i Plant Cell Reports, s. 1359-1367, 2020
- DOI för The life cycle of cyclotides: biosynthesis and turnover in plant cells
- Ladda ner fulltext (pdf) av The life cycle of cyclotides: biosynthesis and turnover in plant cells
Ingår i Phytochemistry Letters, s. 6-11, 2020
Ingår i Journal of Ethnopharmacology, 2020
- DOI för Screening for bioactive secondary metabolites in Sri Lankan medicinal plants by microfractionation and targeted isolation of antimicrobial flavonoids from Derris scandens
- Ladda ner fulltext (pdf) av Screening for bioactive secondary metabolites in Sri Lankan medicinal plants by microfractionation and targeted isolation of antimicrobial flavonoids from Derris scandens
Ingår i Molecules, 2020
- DOI för Evaluating Antimycobacterial Screening Schemes Using Chemical Global Positioning System-Natural Product Analysis
- Ladda ner fulltext (pdf) av Evaluating Antimycobacterial Screening Schemes Using Chemical Global Positioning System-Natural Product Analysis
Ingår i Frontiers in Pharmacology, 2020
- DOI för Ethnobotany and Antimicrobial Peptides From Plants of the Solanaceae Family: An Update and Future Prospects
- Ladda ner fulltext (pdf) av Ethnobotany and Antimicrobial Peptides From Plants of the Solanaceae Family: An Update and Future Prospects
Ingår i Frontiers in Microbiology, 2020
- DOI för Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability
- Ladda ner fulltext (pdf) av Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability
Marine Natural Products: A Source of Novel Anticancer Drugs
Ingår i Marine Drugs, 2019
- DOI för Marine Natural Products: A Source of Novel Anticancer Drugs
- Ladda ner fulltext (pdf) av Marine Natural Products: A Source of Novel Anticancer Drugs
Ingår i Toxins, 2019
Ingår i Journal of Natural Products, s. 798-812, 2019
Ingår i Frontiers in Plant Science, 2018
- DOI för How Does the Sweet Violet (Viola odorata L.) Fight Pathogens and Pests - Cyclotides as a Comprehensive Plant Host Defense System
- Ladda ner fulltext (pdf) av How Does the Sweet Violet (Viola odorata L.) Fight Pathogens and Pests - Cyclotides as a Comprehensive Plant Host Defense System
Briaviolides K-N, New Briarane-Type Diterpenoids from Cultured Octocoral Briareum violaceum
Ingår i Marine Drugs, 2018
- DOI för Briaviolides K-N, New Briarane-Type Diterpenoids from Cultured Octocoral Briareum violaceum
- Ladda ner fulltext (pdf) av Briaviolides K-N, New Briarane-Type Diterpenoids from Cultured Octocoral Briareum violaceum
Ingår i Arthritis & Rheumatology, 2018
Ingår i ACS Chemical Biology, s. 1525-1535, 2018