Läkemedelssäkerhet & Toxikologi

Visualizing DNA single- and double-strand breaks in the Flash comet assay by DNA polymerase-assisted end-labelling

Bivehed, Erik; Hellman, Björn; Wenson, Leonie; Stenerlöw, Bo et al.

Ingår i Nucleic Acids Research, 2024

• DOI för Visualizing DNA single- and double-strand breaks in the Flash comet assay by DNA polymerase-assisted end-labelling
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Screening for antibacterial and cytotoxic activities of Sri Lankan marine sponges through microfractionation: Isolation of bromopyrrole alkaloids from Stylissa massa

Kosgahakumbura, Lakmini; Gamage, Jayani; Robertson, Luke; Muhammad, Taj et al.

Ingår i PLOS ONE, 2024

• DOI för Screening for antibacterial and cytotoxic activities of Sri Lankan marine sponges through microfractionation: Isolation of bromopyrrole alkaloids from Stylissa massa
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Genotoxicity study of Ethiopian medicinal plant extracts on HepG2 cells

Kahaliw, Wubayehu; Hellman, Björn; Engidawork, Ephrem

Ingår i BMC Complementary and Alternative Medicine, 2018

• DOI för Genotoxicity study of Ethiopian medicinal plant extracts on HepG2 cells
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DNA integrity under alkaline conditions: An investigation of factors affecting the comet assay

Bivehed, Erik; Hellman, Björn; Fan, Yuting; Haglöf, Jakob et al.

Ingår i Mutation research. Genetic toxicology and environmental mutagenesis, 2023

• DOI för DNA integrity under alkaline conditions: An investigation of factors affecting the comet assay
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Evaluation of Potential DNA-Damaging Effects of Nitenpyram and Imidacloprid in Human U937-Cells Using a New Statistical Approach to Analyse Comet Data

Bivehed, Erik; Gustafsson, Anton; Berglund, Anders; Hellman, Björn

Ingår i Exposure and Health, s. 547-554, 2020

• DOI för Evaluation of Potential DNA-Damaging Effects of Nitenpyram and Imidacloprid in Human U937-Cells Using a New Statistical Approach to Analyse Comet Data
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Flash-comet: Significantly improved speed and sensitivity of the comet assay through the introduction of lithium-based solutions and a more gentle lysis

Bivehed, Erik; Söderberg, Ola; Hellman, Björn

Ingår i Mutation research. Genetic toxicology and environmental mutagenesis, 2020

• DOI för Flash-comet: Significantly improved speed and sensitivity of the comet assay through the introduction of lithium-based solutions and a more gentle lysis

Myrcene Attenuates Renal Inflammation and Oxidative Stress in the Adrenalectomized Rat Model

Islam, Azim Ullah Shamsul; Hellman, Björn; Nyberg, Fred; Amir, Naheed et al.

Ingår i Molecules, 2020

• DOI för Myrcene Attenuates Renal Inflammation and Oxidative Stress in the Adrenalectomized Rat Model
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An in vitro Study on the DNA Damaging Effects of Phytochemicals Partially Isolated from an Extract of Glinus lotoides

Demma, Jemal; El-Seedi, Hesham; Engidawork, Ephrem; Aboye, Teshome Leta et al.

Ingår i Phytotherapy Research, s. 507-514, 2013

• DOI för An in vitro Study on the DNA Damaging Effects of Phytochemicals Partially Isolated from an Extract of Glinus lotoides

Low levels of the air pollutant 1-nitropyrene induce DNA damage, increased levels of reactive oxygen species and endoplasmic reticulum stress in human endothelial cells

Andersson, Helén; Piras, Elena; Demma, Jemal; Hellman, Björn et al.

Ingår i Toxicology, s. 57-64, 2009

• DOI för Low levels of the air pollutant 1-nitropyrene induce DNA damage, increased levels of reactive oxygen species and endoplasmic reticulum stress in human endothelial cells

An analysis of Vigimed, a global E-mail system for the exchange of pharmacovigilance information

Johansson, K; Olsson, S; Hellman, Björn; Meyboom, RHB

Ingår i Drug Safety, s. 883-889, 2007

Flash-comet assay

Bivehed, Erik; Hellman, Björn

Ingår i MethodsX, 2020

• DOI för Flash-comet assay
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In vitro bioanalysis of drinking water from source to tap

Rosenmai, Anna Kjerstine; Lundqvist, Johan; le Godec, Theo; Ohisson, Asa et al.

Ingår i Water Research, s. 272-280, 2018

• DOI för In vitro bioanalysis of drinking water from source to tap

A bioactivity-guided screening of Sri Lankan plants in the search for novel antibacterial and anticancer agents

Mohotti, S.; Rajendran, S.; Muhammad, Taj; Strömstedt, Adam A. et al.

Ingår i Planta Medica, 2016

• DOI för A bioactivity-guided screening of Sri Lankan plants in the search for novel antibacterial and anticancer agents

Evaluation of catechol-induced DNA damage in human lymphocytes: A comparison between freshly isolated lymphocytes and T-lymphocytes from extended-term cultures

Andersson, Maria; Hellman, Björn

Ingår i Toxicology in Vitro, s. 716-722, 2007

• DOI för Evaluation of catechol-induced DNA damage in human lymphocytes: A comparison between freshly isolated lymphocytes and T-lymphocytes from extended-term cultures

Genotoxicity of plumbagin and its effects on catechol and NQNO-induced DNA damage in mouse lymphoma cells

Demma, Jemal; Hallberg, Karl; Hellman, Björn

Ingår i Toxicology in Vitro, s. 266-271, 2009

• DOI för Genotoxicity of plumbagin and its effects on catechol and NQNO-induced DNA damage in mouse lymphoma cells

Potential genotoxicity of plant extracts used in Ethiopian traditional medicine

Demma, Jemal; Engidawork, E; Hellman, Björn

Ingår i Journal of Ethnopharmacology, s. 136-142, 2009

• DOI för Potential genotoxicity of plant extracts used in Ethiopian traditional medicine

Interindividual differences in initial DNA repair capacity when evaluating H2O2-induced DNA damage in extended-term cultures of human lymphocytes using the comet assay

Andersson, Maria; Stenqvist, Per; Hellman, Björn

Ingår i Cell Biology and Toxicology, s. 401-411, 2007

• DOI för Interindividual differences in initial DNA repair capacity when evaluating H2O2-induced DNA damage in extended-term cultures of human lymphocytes using the comet assay

Evaluation of α-tocopherols effect on catechol and o-phenylenediamine induced DNA damage: An in vitro study using two different staining techniques in the comet assay

Åsgård, Rikard; Håkansson, Sofia; Lundin, Rickard; Hellman, Björn

Pharmacokinetics in Mouse and Comparative Effects of Frondosides in Pancreatic Cancer

Al Shemaili, Jasem; Parekh, Khatija A.; Newman, Robert A.; Hellman, Björn et al.

Ingår i Marine Drugs, 2016

• DOI för Pharmacokinetics in Mouse and Comparative Effects of Frondosides in Pancreatic Cancer
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Fungicide prochloraz induces oxidative stress and DNA damage in vitro

Lundqvist, J.; Hellman, Björn; Oskarsson, A.

Ingår i Food and Chemical Toxicology, s. 36-41, 2016

• DOI för Fungicide prochloraz induces oxidative stress and DNA damage in vitro

Genotoxicity and Cellular Uptake of Cyclotides: Evidence for Multiple Mode of Action

Yeshak, Mariamawit Y; Göransson, Ulf; Burman, Robert; Hellman, Björn

Ingår i Mutation research. Genetic toxicology and environmental mutagenesis, s. 176-181, 2012

• DOI för Genotoxicity and Cellular Uptake of Cyclotides: Evidence for Multiple Mode of Action

Effect of beta-carotene on catechol-induced genotoxicity in vitro: Evidence of both enhanced and reduced DNA damage

Åsgård, Rikard; Hellman, Björn

Ingår i Free radical research, s. 692-698, 2013

• DOI för Effect of beta-carotene on catechol-induced genotoxicity in vitro: Evidence of both enhanced and reduced DNA damage

Evidence for different mechanisms of action behind the mutagenic effects of 4-NOPD and OPD: the role of DNA damage, oxidative stress and an imbalanced nucleotide pool

Åsgård, Rikard; Haghdoost, Siamak; Osterman Golkar, Siv; Hellman, Björn et al.

Ingår i Mutagenesis, s. 637-644, 2013

• DOI för Evidence for different mechanisms of action behind the mutagenic effects of 4-NOPD and OPD: the role of DNA damage, oxidative stress and an imbalanced nucleotide pool

Frondoside A enhances the antiproliferative effects of gemcitabine in pancreatic cancer

Al Shemaili, Jasem; Mensah-Brown, E.; Parekh, K.; Thomas, S. A. et al.

Ingår i European Journal of Cancer, s. 1391-1398, 2014

• DOI för Frondoside A enhances the antiproliferative effects of gemcitabine in pancreatic cancer

Alkaline single cell gel electrophoresis of DNA fragments in biomonitoring for genotoxicity: An introductory study on healthy human volunteers

Hellman, Björn; Vaghef, Hamid; Friis, Lennart; Edling, Christer

Ingår i International Archives of Occupational and Environmental Health, s. 185, 1997

No evidence for a diuretic effect of benzisothiazolinone (BIT) in an experimental animal model employing anaesthetised rats

Hellman, Björn; Sjoquist, Mats; Anundi, Helena; Edling, Christer

Ingår i J Occupational Health, s. 198, 1998

Extended-term cultures of human T-lymphocytes and the comet assay: a useful combination when testing for genotoxicity in vitro?

Andersson, Maria; Agurell, Eva; Vaghef, Hamid; Bolcsfoldi, George et al.

Ingår i Mutation Research, s. 43, 2003

Radiation-induced DNA-damage and gene expression profiles in human lung cancer cells with different radiosensitivity.

Hellman, Björn; Brodin, David; Andersson, Maria; Dahlman-Wright, Karin et al.

Ingår i Exp Oncol, s. 102-7, 2005

Impact of interindividual differences in initial DNA repair capacity when evaluating DNA damage using extended-term cultures of human lymphocytes and the comet assay

Maria, Andersson; Stenqvist, Per; Hellman, Björn

Ingår i Toxicology and applied pharmacology

Extended-term cultures of human T-lymphocytes: a useful combination when testing for genotoxicity in vitro?

Maria, Andersson; Eva, Agurell; Hamid, Vaghef; Bolcsfoldi, George et al.

Ingår i Mutation Research, s. 43-55, 2003

Different roles of Fpg and Endo III on catechol-induced DNA damage in extended-term cultures of human lymphocytes and L5178Y mouse lymphoma cells

Maria, Andersson; Hellman, Björn

Ingår i Toxicology In Vitro, s. 779-786, 2005

Cadmium-induced changes in apoptotic gene expression levels and DNA damage in mouse embryos are blocked by zinc.

Fernández, Estíbaliz L.; Gustafson, Anne-Lee; Andersson, Maria; Hellman, Bjorn et al.

Ingår i Toxicological Sciences, s. 162-170, 2003