Anders Tengholm

Insulin release from isolated cat islets of Langerhans

Strage, Emma M.; Ley, Cecilia; Westermark, Gunilla T.; Tengholm, Anders

Ingår i Domestic Animal Endocrinology, 2024

• DOI för Insulin release from isolated cat islets of Langerhans
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OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion

Panagiotou, Styliani; Tan, Kia Wee; Nguyen, Phuoc My; Mueller, Andreas et al.

Ingår i Cell Reports, 2024

• DOI för OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion
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Indicator-dependent differences in detection of local intracellular Ca2+release events evoked by voltage-gated Ca2+entry in pancreatic & beta;-cells

Yang, Mingyu; Dyachok, Oleg; Xu, Yunjian; Gylfe, Erik et al.

Ingår i Cellular Signalling, 2023

• DOI för Indicator-dependent differences in detection of local intracellular Ca2+release events evoked by voltage-gated Ca2+entry in pancreatic & beta;-cells
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Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Balboa, Diego; Barsby, Tom; Lithovius, Väinö; Saarimäki-Vire, Jonna et al.

Ingår i Nature Biotechnology, s. 1042-1055, 2022

• DOI för Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.
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Glucose-induced cAMP elevation in β-cells involves amplification of constitutive and glucagon-activated GLP-1 receptor signalling

Shuai, Hongyan; Xu, Yunjian; Ahooghalandari, Parvin; Tengholm, Anders

Ingår i Acta Physiologica, 2021

• DOI för Glucose-induced cAMP elevation in β-cells involves amplification of constitutive and glucagon-activated GLP-1 receptor signalling
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Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion

Vishnu, N.; Hamilton, A.; Bagge, A.; Wernersson, A. et al.

Ingår i Molecular Metabolism, 2021

• DOI för Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion

In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis

Petrenko, Volodymyr; Gandasi, Nikhil; Sage, Daniel; Tengholm, Anders et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 2484-2495, 2020

• DOI för In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis
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γ-Hydroxybutyrate does not mediate glucose inhibition of glucagon secretion

Yu, Qian; Lai, Bao Khanh; Ahooghalandari, Parvin; Helander, Anders et al.

Ingår i Journal of Biological Chemistry, 2020

• DOI för γ-Hydroxybutyrate does not mediate glucose inhibition of glucagon secretion
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Metabolic regulation of calcium signaling in beta cells

Idevall Hagren, Olof; Tengholm, Anders

Ingår i Seminars in Cell and Developmental Biology, s. 20-30, 2020

• DOI för Metabolic regulation of calcium signaling in beta cells

Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.

Omar-Hmeadi, Muhmmad; Lund, Per-Eric; Gandasi, Nikhil; Tengholm, Anders et al.

Ingår i Nature Communications, 2020

• DOI för Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.
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ZBED6 negatively regulates insulin production, neuronal differentiation, and cell aggregation in MIN6 cells

Wang, Xuan; Jiang, Lin; Wallerman, Ola; Younis, Shady et al.

Ingår i The FASEB Journal, s. 88-100, 2019

• DOI för ZBED6 negatively regulates insulin production, neuronal differentiation, and cell aggregation in MIN6 cells

The Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 is Essential for Proinsulin Handling

Mojtaba Ghiasi, Seyed; Dahlby, Tina; Hede Andersen, Caroline; Haataja, Leena et al.

Ingår i Diabetes, s. 747-760, 2019

• DOI för The Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 is Essential for Proinsulin Handling

Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis

Gucek, Alenka; Gandasi, Nikhil R; Omar-Hmeadi, Muhmmad; Bakke, Marit et al.

Ingår i eLIFE, 2019

• DOI för Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis
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Glucose controls glucagon secretion by directly modulating cAMP in alpha cells

Yu, Qian; Shuai, Hongyan; Ahooghalandari, Parvin; Gylfe, Erik et al.

Ingår i Diabetologia, s. 1212-1224, 2019

• DOI för Glucose controls glucagon secretion by directly modulating cAMP in alpha cells
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Cyclic AMP links glucose stimulation to somatostatin secretion in delta-cells

Tengholm, Anders

Ingår i The Journal of General Physiology, s. 1062-1065, 2019

• DOI för Cyclic AMP links glucose stimulation to somatostatin secretion in delta-cells

A membrane permeable prodrug of S223 for selective Epac2 activation in living cells

Xu, Yunjian; Schwede, Frank; Wienk, Hans; Tengholm, Anders et al.

Ingår i Cells, 2019

• DOI för A membrane permeable prodrug of S223 for selective Epac2 activation in living cells
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Temporal Dynamics of VEGFA-Induced VEGFR2/FAK Co-Localization Depend on SHB

Pietilä, Ilkka; van Mourik, Djenolan; Tamelander, Andreas; Kriz, Vitezslav et al.

Ingår i Cells, 2019

• DOI för Temporal Dynamics of VEGFA-Induced VEGFR2/FAK Co-Localization Depend on SHB
• Ladda ner fulltext (pdf) av Temporal Dynamics of VEGFA-Induced VEGFR2/FAK Co-Localization Depend on SHB

A genetically encoded low-affinity Ca2+ sensor unmasks autocrine purinergic signalling in beta cells

Yang, Mingyu; Idevall-Hagren, Olof; Gylfe, Erik; Tengholm, Anders

Ingår i Diabetologia, 2018

Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells

Korol, Sergiy V; Jin, Zhe; Jin, Yang; Bhandage, Amol K. et al.

Ingår i EBioMedicine, 2018

• DOI för Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells
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cAMP signalling in insulin and glucagon secretion

Tengholm, Anders; Gylfe, Erik

Ingår i Diabetes, obesity and metabolism, s. 42-53, 2017

• DOI för cAMP signalling in insulin and glucagon secretion

Recruitment of Epac2A to Insulin Granule Docking Sites Regulates Priming for Exocytosis

Alenkvist, Ida; Gandasi, Nikhil R; Barg, Sebastian; Tengholm, Anders

Ingår i Diabetes, s. 2610-2622, 2017

• DOI för Recruitment of Epac2A to Insulin Granule Docking Sites Regulates Priming for Exocytosis

ZBED6 negatively regulates insulin content, glucose-stimulated insulin secretion, neuronal differentiation and cell aggregation in MIN6 cells

Wang, Xuan; Jiang, L.; Wallerman, Ola; Yu, Qian et al.

Ingår i Diabetologia, 2016

Glucose lowers cAMP to inhibit glucagon secretion by a direct effect on alpha cells

Yu, Qian; Shuai, Hongyan; Ahooghalandari, Parvin; Gylfe, Erik et al.

Ingår i Diabetologia, 2016

Autocrine Signaling Underlies Fast Repetitive Plasma Membrane Translocation of Conventional and Novel Protein Kinase C Isoforms in beta Cells

Wuttke, Anne; Yu, Qian; Tengholm, Anders

Ingår i Journal of Biological Chemistry, s. 14986-14995, 2016

• DOI för Autocrine Signaling Underlies Fast Repetitive Plasma Membrane Translocation of Conventional and Novel Protein Kinase C Isoforms in beta Cells
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CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion

Abels, Mia; Riva, Matteo; Bennet, Hedvig; Ahlqvist, Emma et al.

Ingår i Diabetologia, s. 1928-1937, 2016

• DOI för CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion

Fluorescent protein vectors for pancreatic islet cell identification in live-cell imaging

Shuai, Hongyan; Xu, Yunjian; Yu, Qian; Gylfe, Erik et al.

Ingår i Pflügers Archiv, s. 1765-1777, 2016

• DOI för Fluorescent protein vectors for pancreatic islet cell identification in live-cell imaging
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Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes

Tuomi, Tiinamaija; Nagorny, Cecilia L. F.; Singh, Pratibha; Bennet, Hedvig et al.

Ingår i Cell Metabolism, s. 1067-1077, 2016

• DOI för Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes

CART is a novel glucose-dependent peptide with antidiabetic actions in humans

Abels, M.; Riva, M.; Poon, W.; Bennet, H. et al.

Ingår i Diabetologia, 2015

Paradoxical Ca2+ kinetics in islet-located glucagon-releasing alpha cells

Yu, Qian; Li, Jia; Ahooghalandari, Parvin; Tengholm, Anders et al.

Ingår i Diabetologia, 2015

Imaging sub-plasma membrane cAMP dynamics with fluorescent translocation reporters

Tengholm, Anders; Idevall-Hagren, Olof

Ingår i cAMP Signaling, s. 85-101, Springer-Verlag New York, 2015

• DOI för Imaging sub-plasma membrane cAMP dynamics with fluorescent translocation reporters
• Ladda ner fulltext (pdf) av Imaging sub-plasma membrane cAMP dynamics with fluorescent translocation reporters

Neuropeptide S inhibits gastrointestinal motility and increases mucosal permeability through nitric oxide

Wan Saudi, Wan Salman; Halim, Mohammed Abdul; Gillberg, Linda; Rudholm-Feldreich, Tobias et al.

Ingår i American Journal of Physiology - Gastrointestinal and Liver Physiology, 2015

• DOI för Neuropeptide S inhibits gastrointestinal motility and increases mucosal permeability through nitric oxide

Impaired cAMP generation contributes to defective glucose-stimulated insulin secretion after long-term exposure to palmitate

Tian, Geng; Sol, Eri Maria; Xu, Yunjian; Shuai, Hongyan et al.

Ingår i Diabetes, s. 904-915, 2015

• DOI för Impaired cAMP generation contributes to defective glucose-stimulated insulin secretion after long-term exposure to palmitate
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Submembrane ATP and Ca2+ kinetics in alpha-cells: unexpected signaling for glucagon secretion

Li, Jia; Yu, Qian; Ahooghalandari, Parvin; Gribble, Fiona M. et al.

Ingår i The FASEB Journal, s. 3379-3388, 2015

• DOI för Submembrane ATP and Ca2+ kinetics in alpha-cells: unexpected signaling for glucagon secretion

Submembrane ATP and Ca²⁺ kinetics in α‑cells: unexpected signaling for glucagon secretion

Li, Jia; Yu, Qian; Ahooghalandari, Parvin; Gribble, Fiona M et al.

Ingår i The FASEB Journal, s. 3379-3388, 2015

• DOI för Submembrane ATP and Ca²⁺ kinetics in α‑cells: unexpected signaling for glucagon secretion

Prolonged exposure to palmitate deteriorates glucose-induced cAMP generation and pulsatile insulin secretion

Tian, Geng; Tengholm, Anders

Ingår i Diabetes/Metabolism Research Reviews, s. 9-10, 2015

Paradoxical synchronisation of Ca2+ oscillations between alpha and beta cells within intact pancreatic islets

Yu, Qian; Li, Jia; Tengholm, Anders; Gylfe, Erik

Ingår i Diabetologia, 2014

Absence of Shb impairs insulin secretion by elevated FAK activity in pancreatic islets

Alenkvist, Ida; Dyachok, Oleg; Tian, Geng; Li, Jia et al.

Ingår i Journal of Endocrinology, s. 267-275, 2014

• DOI för Absence of Shb impairs insulin secretion by elevated FAK activity in pancreatic islets
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Neurotransmitter control of islet hormone pulsatility

Gylfe, Erik; Tengholm, Anders

Ingår i Diabetes, obesity and metabolism, s. 102-110, 2014

• DOI för Neurotransmitter control of islet hormone pulsatility

Purinergic P2Y1 receptors take centre stage in autocrine stimulation of human beta cells

Tengholm, Anders

Ingår i Diabetologia, s. 2436-2439, 2014

• DOI för Purinergic P2Y1 receptors take centre stage in autocrine stimulation of human beta cells
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Prolonged exposure to palmitate deteriorates glucose-induced cAMP generation and pulsatile insulin secretion

Tian, Geng; Sol, E. -RM.; Xu, Yunjian; Tengholm, Anders

Ingår i Diabetologia, 2013

Autocrine signals mediate plasma membrane translocation of protein kinase C in insulin-secreting cells

Tengholm, Anders; Wuttke, Anne

Ingår i Diabetologia, 2013

Functional differences between aggregated and dispersed insulin-producing cells

Chowdhury, Azazul Islam; Dyachok, Oleg; Tengholm, Anders; Sandler, Stellan et al.

Ingår i Diabetologia, s. 1557-1568, 2013

• DOI för Functional differences between aggregated and dispersed insulin-producing cells
• Ladda ner fulltext (pdf) av Functional differences between aggregated and dispersed insulin-producing cells

Oscillations of sub-membrane ATP in glucose-stimulated beta cells depend on negative feedback from Ca2+

Li, Jia; Shuai, Hongyan; Gylfe, Erik; Tengholm, Anders

Ingår i Diabetologia, s. 1577-1586, 2013

• DOI för Oscillations of sub-membrane ATP in glucose-stimulated beta cells depend on negative feedback from Ca2+
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Aberrant association between vascular endothelial growth factor receptor-2 and VE-cadherin in response to vascular endothelial growth factor-a in Shb-deficient lung endothelial cells

Zang, Guangxiang; Christoffersson, Gustaf; Tian, Geng; Harun-Or-Rashid, Mohammad et al.

Ingår i Cellular Signalling, s. 85-92, 2013

• DOI för Aberrant association between vascular endothelial growth factor receptor-2 and VE-cadherin in response to vascular endothelial growth factor-a in Shb-deficient lung endothelial cells
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DNA Methylation of Alternative Promoters Directs Tissue Specific Expression of Epac2 Isoforms

Hoivik, Erling A.; Witsoe, Solveig L.; Bergheim, Inger R.; Xu, Yunjian et al.

Ingår i PLOS ONE, 2013

• DOI för DNA Methylation of Alternative Promoters Directs Tissue Specific Expression of Epac2 Isoforms
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The role of mechanical force and ROS in integrin-dependent signals

Zeller, Kathrin Stephanie; Riaz, Anjum; Sarve, Hamid; Li, Jia et al.

Ingår i PLOS ONE, 2013

• DOI för The role of mechanical force and ROS in integrin-dependent signals
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Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5'-phosphatase interaction with c-Abl

Mokhtari, Dariush; Al-Amin, Abdullah; Turpaev, Kyrill; Li, Tingting et al.

Ingår i Diabetologia, s. 1327-1338, 2013

• DOI för Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5'-phosphatase interaction with c-Abl
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P2Y₁ receptor-dependent diacylglycerol signaling microdomains in β cells promote insulin secretion

Wuttke, Anne; Idevall-Hagren, Olof; Tengholm, Anders

Ingår i The FASEB Journal, s. 1610-1620, 2013

• DOI för P2Y₁ receptor-dependent diacylglycerol signaling microdomains in β cells promote insulin secretion

Spatial Control of Epac2 Activity by cAMP and Ca2+-Mediated Activation of Ras in Pancreatic beta Cells

Idevall-Hagren, Olof; Jakobsson, Ida; Xu, Yunjian; Tengholm, Anders

Ingår i Science Signaling, 2013

• DOI för Spatial Control of Epac2 Activity by cAMP and Ca2+-Mediated Activation of Ras in Pancreatic beta Cells

Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion

Tian, Geng; Sågetorp, Jenny; Xu, Yunjian; Shuai, Hongyan et al.

Ingår i Journal of Cell Science, s. 5084-5095, 2012

• DOI för Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion