Erik Gylfe

Kungl. Vetenskaps-Societetens ledamöter 1710–2025

Gylfe, Erik

Acta Universitatis Upsaliensis, 2025

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Bo Hellman, 19 June 1930-4 December 2023

Gylfe, Erik; Tengholm, Anders

Ingår i Diabetologia, s. 1165-1167, 2024

• DOI för Bo Hellman, 19 June 1930-4 December 2023

Indicator-dependent differences in detection of local intracellular Ca2+release events evoked by voltage-gated Ca2+entry in pancreatic & beta;-cells

Yang, Mingyu; Dyachok, Oleg; Xu, Yunjian; Gylfe, Erik et al.

Ingår i Cellular Signalling, 2023

• DOI för Indicator-dependent differences in detection of local intracellular Ca2+release events evoked by voltage-gated Ca2+entry in pancreatic & beta;-cells
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γ-Hydroxybutyrate does not mediate glucose inhibition of glucagon secretion

Yu, Qian; Lai, Bao Khanh; Ahooghalandari, Parvin; Helander, Anders et al.

Ingår i Journal of Biological Chemistry, 2020

• DOI för γ-Hydroxybutyrate does not mediate glucose inhibition of glucagon secretion
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Glucose controls glucagon secretion by directly modulating cAMP in alpha cells

Yu, Qian; Shuai, Hongyan; Ahooghalandari, Parvin; Gylfe, Erik et al.

Ingår i Diabetologia, s. 1212-1224, 2019

• DOI för Glucose controls glucagon secretion by directly modulating cAMP in alpha cells
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Bo Hellman, 19 June 1930-4 December 2023

Gylfe, Erik; Tengholm, Anders

Ingår i Diabetologia, s. 1165-1167, 2024

• DOI för Bo Hellman, 19 June 1930-4 December 2023

Indicator-dependent differences in detection of local intracellular Ca2+release events evoked by voltage-gated Ca2+entry in pancreatic & beta;-cells

Yang, Mingyu; Dyachok, Oleg; Xu, Yunjian; Gylfe, Erik et al.

Ingår i Cellular Signalling, 2023

• DOI för Indicator-dependent differences in detection of local intracellular Ca2+release events evoked by voltage-gated Ca2+entry in pancreatic & beta;-cells
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γ-Hydroxybutyrate does not mediate glucose inhibition of glucagon secretion

Yu, Qian; Lai, Bao Khanh; Ahooghalandari, Parvin; Helander, Anders et al.

Ingår i Journal of Biological Chemistry, 2020

• DOI för γ-Hydroxybutyrate does not mediate glucose inhibition of glucagon secretion
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Glucose controls glucagon secretion by directly modulating cAMP in alpha cells

Yu, Qian; Shuai, Hongyan; Ahooghalandari, Parvin; Gylfe, Erik et al.

Ingår i Diabetologia, s. 1212-1224, 2019

• DOI för Glucose controls glucagon secretion by directly modulating cAMP in alpha cells
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A genetically encoded low-affinity Ca2+ sensor unmasks autocrine purinergic signalling in beta cells

Yang, Mingyu; Idevall-Hagren, Olof; Gylfe, Erik; Tengholm, Anders

Ingår i Diabetologia, 2018

Fluorescent protein vectors for pancreatic islet cell identification in live-cell imaging

Shuai, Hongyan; Xu, Yunjian; Yu, Qian; Gylfe, Erik et al.

Ingår i Pflügers Archiv, s. 1765-1777, 2016

• DOI för Fluorescent protein vectors for pancreatic islet cell identification in live-cell imaging
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Glucose lowers cAMP to inhibit glucagon secretion by a direct effect on alpha cells

Yu, Qian; Shuai, Hongyan; Ahooghalandari, Parvin; Gylfe, Erik et al.

Ingår i Diabetologia, 2016

Submembrane ATP and Ca²⁺ kinetics in α‑cells: unexpected signaling for glucagon secretion

Li, Jia; Yu, Qian; Ahooghalandari, Parvin; Gribble, Fiona M et al.

Ingår i The FASEB Journal, s. 3379-3388, 2015

• DOI för Submembrane ATP and Ca²⁺ kinetics in α‑cells: unexpected signaling for glucagon secretion

Submembrane ATP and Ca2+ kinetics in alpha-cells: unexpected signaling for glucagon secretion

Li, Jia; Yu, Qian; Ahooghalandari, Parvin; Gribble, Fiona M. et al.

Ingår i The FASEB Journal, s. 3379-3388, 2015

• DOI för Submembrane ATP and Ca2+ kinetics in alpha-cells: unexpected signaling for glucagon secretion

Paradoxical Ca2+ kinetics in islet-located glucagon-releasing alpha cells

Yu, Qian; Li, Jia; Ahooghalandari, Parvin; Tengholm, Anders et al.

Ingår i Diabetologia, 2015

Paradoxical synchronisation of Ca2+ oscillations between alpha and beta cells within intact pancreatic islets

Yu, Qian; Li, Jia; Tengholm, Anders; Gylfe, Erik

Ingår i Diabetologia, 2014

Oscillations of sub-membrane ATP in glucose-stimulated beta cells depend on negative feedback from Ca2+

Li, Jia; Shuai, Hongyan; Gylfe, Erik; Tengholm, Anders

Ingår i Diabetologia, s. 1577-1586, 2013

• DOI för Oscillations of sub-membrane ATP in glucose-stimulated beta cells depend on negative feedback from Ca2+
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Glucose Control of Glucagon Secretion: There Is More to It Than K-ATP Channels

Gylfe, Erik

Ingår i Diabetes, s. 1391-1393, 2013

• DOI för Glucose Control of Glucagon Secretion: There Is More to It Than K-ATP Channels

cAMP Induces Stromal Interaction Molecule 1 (STIM1) Puncta but neither Orai1 Protein Clustering nor Store-operated Ca2+ Entry (SOCE) in Islet Cells

Tian, Geng; Tepikin, Alexei V.; Tengholm, Anders; Gylfe, Erik

Ingår i Journal of Biological Chemistry, s. 9862-9872, 2012

• DOI för cAMP Induces Stromal Interaction Molecule 1 (STIM1) Puncta but neither Orai1 Protein Clustering nor Store-operated Ca2+ Entry (SOCE) in Islet Cells
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Isolated mouse islets respond to glucose with an initial peak of glucagon release followed by pulses of insulin and somatostatin in antisynchrony with glucagon

Hellman, Bo; Salehi, Albert; Grapengiesser, Eva; Gylfe, Erik

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 1219-1223, 2012

• DOI för Isolated mouse islets respond to glucose with an initial peak of glucagon release followed by pulses of insulin and somatostatin in antisynchrony with glucagon

The Neurotransmitter ATP Triggers Ca²⁺ Responses Promoting Coordination of Pancreatic Islet Oscillations

Gylfe, Erik; Grapengiesser, Eva; Dansk, Heléne; Hellman, Bo

Ingår i Pancreas, s. 258-263, 2012

• DOI för The Neurotransmitter ATP Triggers Ca²⁺ Responses Promoting Coordination of Pancreatic Islet Oscillations

Glucose- and Hormone-Induced cAMP Oscillations in α- and β-Cells Within Intact Pancreatic Islets

Tian, Geng; Sandler, Stellan; Gylfe, Erik; Tengholm, Anders

Ingår i Diabetes, s. 1535-1543, 2011

• DOI för Glucose- and Hormone-Induced cAMP Oscillations in α- and β-Cells Within Intact Pancreatic Islets

Ghrelin Attenuates cAMP-PKA Signaling to Evoke Insulinostatic Cascade in Islet beta-Cells

Dezaki, Katsuya; Damdindorj, Boldbaatar; Sone, Hideyuki; Dyachok, Oleg et al.

Ingår i Diabetes, s. 2315-2324, 2011

• DOI för Ghrelin Attenuates cAMP-PKA Signaling to Evoke Insulinostatic Cascade in Islet beta-Cells

cAMP Mediators of Pulsatile Insulin Secretion from Glucose-stimulated Single β-Cells

Idevall Hagren, Olof; Barg, Sebastian; Gylfe, Erik; Tengholm, Anders

Ingår i Journal of Biological Chemistry, s. 23005-23016, 2010

• DOI för cAMP Mediators of Pulsatile Insulin Secretion from Glucose-stimulated Single β-Cells

Crosstalk between cAMP- and Zn2+-signalling in insulin secretion

Dyachok, Oleg; Idevall, Olof; Tengholm, Anders; Gylfe, Erik

Ingår i Diabetologia, 2010

Glucose regulation of STIM1 translocation reflecting store-operated channel modulation in pancreatic islet cells

Tian, Geng; Tepikin, A. V.; Tengholm, Anders; Gylfe, Erik

Ingår i Diabetologia, 2010

Glucose induces oscillations of the ATP/ADP ratio in individual beta cells

Li, Jia; Gylfe, Erik; Tengholm, Anders

Ingår i Diabetologia, 2010

Glucose generates coincident insulin and somatostatin pulses and anti-synchronous glucagon pulses from human pancreatic islets

Hellman, Bo; Salehi, Albert; Gylfe, Erik; Dansk, Heléne et al.

Ingår i Endocrinology, s. 5334-5340, 2009

• DOI för Glucose generates coincident insulin and somatostatin pulses and anti-synchronous glucagon pulses from human pancreatic islets

Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion

Dyachok, Oleg; Idevall-Hagren, Olof; Sågetorp, Jenny; Tian, Geng et al.

Ingår i Cell Metabolism, s. 26-37, 2008

• DOI för Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion
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Insulinoscillationer - en kliniskt betydelsefull rytmik. Diabetesläkemedel bör öka den pulsatila komponenten av insulinfrisättningen: Insulin oscillations -- clinically important rhythm. Antidiabetics should increase the pulsatile component of insulin release

Hellman, Bo; Gylfe, Erik; Grapengiesser, Eva; Dansk, Helene et al.

Ingår i Läkartidningen, s. 2236-2239, 2007

Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells

Vieira, Elaine; Salehi, Albert; Gylfe, Erik

Ingår i Diabetologia, s. 370-379, 2007

• DOI för Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells
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Paradoxical stimulation of glucagon secretion by high glucose concentrations

Salehi, Albert; Vieira, Elaine; Gylfe, Erik

Ingår i Diabetes, s. 2318-2323, 2006

• DOI för Paradoxical stimulation of glucagon secretion by high glucose concentrations
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Feedback activation of phospholipase C via intracellular mobilization and store-operated influx of Ca²⁺ in insulin-secreting β-cells

Thore, Sophia; Dyachok, Oleg; Gylfe, Erik; Tengholm, Anders

Ingår i Journal of Cell Science, s. 4463-4471, 2005

• DOI för Feedback activation of phospholipase C via intracellular mobilization and store-operated influx of Ca²⁺ in insulin-secreting β-cells
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Protein Kinase C Modulates Agonist-sensitive Release of Ca2+ from Internal Stores in HEK293 Cells Overexpressing the Calcium Sensing Receptor.

Sakwe, Amos M; Rask, Lars; Gylfe, Erik

Ingår i J Biol Chem, s. 4436-41, 2005

Ca²⁺-induced Ca²⁺ release by activation of inositol 1,4,5-trisphosphate receptors in primary pancreatic β-cells

Dyachok, Oleg; Tufveson, Gunnar; Gylfe, Erik

Ingår i Cell Calcium, s. 1-9, 2004

• DOI för Ca²⁺-induced Ca²⁺ release by activation of inositol 1,4,5-trisphosphate receptors in primary pancreatic β-cells
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Ca²+-induced Ca²+ Release via Inositol 1,4,5-trisphosphate Receptors Is Amplified by Protein Kinase A and Triggers Exocytosis in Pancreatic β-Cells

Dyachok, Oleg; Gylfe, Erik

Ingår i Journal of Biological Chemistry, s. 45455-45461, 2004

• DOI för Ca²+-induced Ca²+ Release via Inositol 1,4,5-trisphosphate Receptors Is Amplified by Protein Kinase A and Triggers Exocytosis in Pancreatic β-Cells
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A store-operated mechanism determines the activity of the electrically excitable glucagon-secreting pancreatic Alfa-cell

Liu, Yi-Jia; Vieira, Elaine; Gylfe, Erik

Ingår i Cell Calcium, s. 357-365, 2004

Involvement of Alfa1 and Beta-adrenoceptors in adrenaline stimulation fo the glucagon-secreting mouse Alfa-cell

Vieira, Elaine; Liu, Yi-Jia; Gylfe, Erik

Ingår i Naunyn-Schmiedeberg´s Arch Pharmacol, s. 179-183, 2004

The Hepatitis C Virus Core Protein Modulates T Cell Responses by Inducing Spontaneous and Altering T-cell Receptor-triggered Ca²⁺ Oscillations

Bergqvist, Anders; Sundström, Sara; Dimberg, Lina Y.; Gylfe, Erik et al.

Ingår i Journal of Biological Chemistry, s. 18877-18883, 2003

• DOI för The Hepatitis C Virus Core Protein Modulates T Cell Responses by Inducing Spontaneous and Altering T-cell Receptor-triggered Ca²⁺ Oscillations

Store-operated influx of Ca²⁺ in the pancreatic β-cells exhibits graded dependence on the filling of the endoplasmic reticulum

Dyachok, Oleg; Gylfe, Erik

Ingår i Journal of Cell Science, s. 2179-2186, 2001

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Defective glucose-dependent cytosolic Ca2+ handling in islets of GK and nSTZ rat models of type 2 diabetes

Marie, JC; Bailbe, D; Gylfe, Erik; Portha, B

Ingår i J Endocrinol, s. 169, 2001

Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the Interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells

Lindholm, Cecilia K; Gylfe, Erik; Zhang, Weigu; Samelson, Lawrence E et al.

Ingår i Journal of Biological Chemistry, s. 28050-28057, 1999

• DOI för Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the Interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells

Oscillatory Ca2+ signaling in somatostatin-producing cells from the human pancreas

Berts, Alf; Liu, Yi-Jia; Gylfe, Erik; Hellman, Bo

Ingår i Metabolism, s. 366-369, 1997

• DOI för Oscillatory Ca2+ signaling in somatostatin-producing cells from the human pancreas

Suppression of Ca2+ oscillations in glucagon-producing alfa2-cells by insulin/glucose and amino acids

Berts, Alf; Ball, Andrew; Gylfe, Erik; Hellman, Bo

Ingår i Biochimica et Biophysica Acta, s. 212-216, 1996

Glucose stimulation of somatostatin-producing islet cells involves oscillatory Ca2+ signaling

Berts, A; Dryselius, S; Gylfe, E; Hellman, B

Ingår i Endocrinology, s. 693, 1996

Glucose induces oscillations of cytoplasmic Ca2+, Sr2+ and Ba2+ in pancreatic beta-cells without participation of the thapsigargin-sensitive store

Liu, Y-J; Grapengiesser, Eva; Gylfe, Erik; Hellman, Bo

Ingår i Cell Calcium, s. 165-173, 1995

Coincidence of early glucose-induced depolarization with lowering of cytoplasmic Ca2+ in mouse pancreatic beta-cells

Chow, R H; Lund, P-E; Löser, S; Panten, U et al.

Ingår i Journal of Physiology, s. 607-617, 1995

Ca2+-induced Ca2+ oscillations in parathyroid cells

Ridefelt, Peter; Bjorklund, E; Åkerström, Göran; Olsson, MJ et al.

Ingår i Biochem Biophys Rew Commun, s. 903, 1995

Effects of the antihypercalcemic drugs gallium nitrate and pamidronate on hormone release of pathologic human parathyroid cells

Ridelfelt, Peter; Gylfe, Erik; Åkerström, Göran; Ljunghall, Sverker et al.

Ingår i Surgery, s. 56, 1995

Glucose controls glucagon secretion by directly modulating cAMP in α‑cells

Yu, Qian; Shuai, Hongyan; Ahooghalandari, Parvin; Gylfe, Erik et al.

cAMP signalling in insulin and glucagon secretion

Tengholm, Anders; Gylfe, Erik

Ingår i Diabetes, obesity and metabolism, s. 42-53, 2017

• DOI för cAMP signalling in insulin and glucagon secretion

Glucose control of glucagon secretion: 'There's a brand-new gimmick every year'

Gylfe, Erik

Ingår i Upsala Journal of Medical Sciences, s. 120-132, 2016

• DOI för Glucose control of glucagon secretion: 'There's a brand-new gimmick every year'
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Neurotransmitter control of islet hormone pulsatility

Gylfe, Erik; Tengholm, Anders

Ingår i Diabetes, obesity and metabolism, s. 102-110, 2014

• DOI för Neurotransmitter control of islet hormone pulsatility

Glucose regulation of glucagon secretion

Gylfe, Erik; Gilon, Patrick

Ingår i Diabetes Research and Clinical Practice, s. 1-10, 2014

• DOI för Glucose regulation of glucagon secretion

Oscillatory control of insulin secretion

Tengholm, Anders; Gylfe, Erik

Ingår i Molecular and Cellular Endocrinology, s. 58-72, 2009

• DOI för Oscillatory control of insulin secretion
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Kungl. Vetenskaps-Societetens ledamöter 1710–2025

Gylfe, Erik

Acta Universitatis Upsaliensis, 2025

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Ca2+ signalling underlying pulsatile insulin secretion

Gylfe, Erik

Ingår i Diabetes mellitus combat the challenge, s. 96-115, 2005

Quantitative assessment of glucose-regulated cAMP signalling and protein kinase A-mediated glucagon secretion.

Yu, Qian; Gylfe, Erik; Tengholm, Anders

Department of Medical Cell Biology: Annual Report 2013

Gylfe, Erik

Uppsala universitet, 2014

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Department of Medical Cell Biology: Annual Report 2012

Gylfe, Erik

Institutionen för medicinsk cellbiologi, 2013

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Department of Medical Cell Biology: Annual Report 2011

Gylfe, Erik

Institutionen för medicinsk cellbiologi, 2012

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Department of Medical Cell Biology: Annual Report 2010

Gylfe, Erik

Institutionen för medicinsk cellbiologi, Uppsala universitet, 2011

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Department of Medical Cell Biology: Annual Report 2009

Gylfe, Erik

Institutionen för medicinsk cellbiologi, Uppsala universitet, 2010

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